Professor Olwyn Byron

  • Professor of Biophysics (Life Sciences Infection Biology)

telephone: 01413303752
email: Olwyn.Byron@glasgow.ac.uk

Research interests

Research Interests

We specialise in understanding the solution behaviour of biological macromolecules and their complexes. We do this by utilising a number of biophysical techniques to determine the solution shape of molecules and the strength, stoichiometry and architecture of the complexes they form.  We collaborate widely and offer expertise in the application of our core methodologies including:

  • Analytical ultracentrifugation (AUC)
  • Small angle X-ray scattering (SAXS)
  • Small angle neutron scattering (SANS)
  • Hydrodynamic bead modelling (HBM)

Click here to see recent publication highlights

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Where and Why: The Influence of Host Metabolism on Bacterial Niche Specificity
    Biotechnology and Biological Sciences Research Council
    2016 - 2019
     
  • A novel mechanism of protein uptake in Gram-negative bacteria
    Biotechnology and Biological Sciences Research Council
    2014 - 2017
     
  • ISG-EPSRC: Equipment
    Engineering & Physical Sciences Research Council
    2012 - 2013
     
  • Solution and structure of human PDC [Pyruvate Dehydrogenase Complex] Core
    Council for the Central Laboratory of the Research Councils
    2007 - 2007
     

Teaching

Undergraduate Teaching

Level 1 Microbiology and Virology lectures
Level 2 Microbiology 2c laboratories
Level 3 Medical Microbiology lectures and tutorials
Level 4 Core Skills in Microbiology, Parasitology & Virology lectures and tutorials
Level 4 Bacterial Virulence lectures
Level 4 Microbiology Advanced Studies lectures and tutorials

Pastoral Care

Adviser of Studies

Academic Leadership

Deputy Director, Wellcome Trust University of Glasgow 4-Year PhD Programme Molecular Functions in Disease
Chair, School of Life Sciences Athena SWAN committee
Lead, School of Life Sciences Year 4
Coordinator, Level 4 Microbiology
Coordinator, Level 4 Microbiology Advanced Studies
Coordinator, Level 4 Core Skills in Microbiology, Parasitology & Virology Option

Committee Membership

School of Life Sciences Management Committee
School of Life Sciences Learning and Teaching Committee
School of Life Sciences Mentoring and Career Development Group
School of Life Sciences Learning Examinations and Assessment Committee
School of Life Sciences Infection Biology Degree Group Committee
College of Medical, Veterinary and Life Sciences Gender Equality Committee
St Andrew's Society of the State of New York Scholarship interview panel University Senate

Additional information

Editorial Board

  • 2014 - ongoing: Frontiers in Structural Biology - Review Editorial Board
  • 2000 - 2009: Biophysical Chemistry

Grant Advisory Board

  • 2014 - ongoing: NRC Kurchatov Institute, Gatchina, Russia, Neutron Science Advisory Committee - Member
  • 2014 - ongoing: Science & Technology Facilities Council (STFC) - Member, Consolidated Grants Implementation Review Panel
  • 2013 - ongoing: ILL, France - Member, Proposals Review Panel for Deuteration Laboratory
  • 2012 - ongoing: University of Strathclyde, UK - Member, Scottish Centre for the Application of Plasma-based Accelerators
  • 2012 - 2013: Science and Technology Facilities Council (STFC) - Chair, Large Facilities Sub-group of STFC Programmatic Review
  • 2012 - 2015: Universities of Strathclyde, Huddersfield, Surrey and Queens, Belfast - Member, Advisory Board for the Centre for Doctoral Training (CDT) in Applications of Next Generation Accelerators
  • 2011 - 2014: Science and Technology Facilities Council (STFC) - Member, Science Board
  • 2011 - 2014: European Spallation Source (ESS) - Member, SANS Scientific and Technical Advisory Panel
  • 2010 - 2011: Science and Technology Facilities Council (STFC) - Member, Physical and Life Sciences Committee
  • 2009 - 2011: Science and Technology Facilities Council (STFC) - Member, Neutron Advisory Panel
  • 2007 - ongoing: Stanford Synchrotron Radiation Laboratory - US - Reviewer
  • 2006 - ongoing: OPAL Neutron Source, Australia - Reviewer
  • 2006 - 2009: Heinz Maier-Leibnitz (FRM-II) Research Neutron Source, Germany - Member, review committee
  • 2006 - 2010: Institut Laue Langevin, France - Member, Scientific Council
  • 2006 - 2010: Science & Technology Facilities Council (STFC)-Institut Laue Langevin - Member, Steering Committee
  • 2004 - 2004: Engineering and Physical Sciences Research Council (EPSRC) - Member, Physics/Life Sciences expert panel
  • 2003 - 2005: Daresbury Laboratory Synchrotron Radiation Source - Member, Biology and Medicine Facility Access Panel
  • 2003 - 2004: ISIS Spallation Neutron Source, Rutherford Appleton Laboratory - Member, Large Scale Structures Instrument Scheduling Panel
  • 2001 - 2004: European Spallation Source (ESS) - Member, Biology and Biotechnology Subgroup of the Scientific Advisory Council
  • 2001 - 2004: ABRF (Association of Biomolecular Resource Facilities) - Member, Molecular Interactions Research Group
  • 1999 - 2002: Biotechnology and Biological Sciences Research Council (BBSRC) - Member, Biology and Neutrons Advisory Panel
  • 1999 - 2002: Member, Subcommittee 8 (Biology)
  • 1998 - 2003: British Biochemical Society - Member, Techniques Group Committee
  • 1997 - 1999: ISIS Spallation Neutron Source, Rutherford Appleton Laboratory - Member, Crystal Analysers Instrument Scheduling Panel

Invited International Presentations

  • 2017: Edinburgh, UK - Scientific programme and organisation committee member, 19th International Union for Pure and Applied Biophysics (IUPAB) Congress and 11th European Biophysical Association Societies (EBSA) Congress
  • 2016: Seoul & Gyeongbuk, Korea - Invited lecturer, EMBO Global Exchange Lecture Course on Structural and Biophysical Methods for Biological Macromolecules in solution. Combination of scattering and biophysical methods; Analytical ultracentrifugation
  • 2016: Hamburg, Germany - Invited lecturer, EMBO Practical Course on solution scattering from biological macromolecules. Joint applications of SAXS/SANS and hydrodynamic methods in the studies of biomacromolecular solutions
  • 2015: Melbourne, Australia - International programme committee member, 22nd International Conference on Analytical Ultracentrifugation (AUC2015)
  • 2015: Ismaning, Germany - Invited plenary speaker, Workshop on Trends in Neutron Science, MLZ User Meeting. Small-angle neutron scattering: a pivotal role in biomolecular structure-function determination
  • 2015: Taipei, Taiwan - Invited lecturer, EMBO Global Exchange Lecture Course on Structural and Biophysical Methods for Biological Macromolecules in solution. Combination of scattering and biophysical methods; Analytical ultracentrifugation
  • 2015: Grenoble, France - Invited lecturer, EMBO Practical Course on Small Angle Neutron and X-ray Scattering from Proteins in Solution. Structural information obtained from analytical ultracentrifugation.
  • 2014: Warwick, England, UK - Session co-chair, British Biophysical Society Biennial Meeting
  • 2014: Sao Paulo, Brazil - Invited lecturer, EMBO Global Exchange Lecture Course on Structural and Biophysical Methods for Biological Macromolecules in solution. Combination of scattering and biophysical methods; Analytical ultracentrifugation
  • 2014: Hamburg, Germany - Invited lecturer, EMBO Practical Course on solution scattering from biological macromolecules. Joint applications of SAXS/SANS and hydrodynamic methods in the studies of biomacromolecular solutions
  • 2014: London, UK - Invited speaker, BBS Symposium on Complementary Non-Diffraction Techniques in Structural Biology. Multitasking like a woman: the emergence of simultaneous methodologies in small-angle scattering and hydrodynamics
  • 2014: Grenoble, France - Invited speaker and organising committee member, ICNS Satellite Meeting: Neutrons in Biology and Biotechnology. Architecture of human pyruvate dehydrogenase complex determined with SAXS, SANS and AUC
  • 2014: Brno, Czech Republic - Invited speaker, "Current State-of-Art to Study Biomolecular Interactions and Assemblies in Life Sciences". Biomolecular interactions observed and quantified with AUC and SAS
  • 2013: Edinburgh, UK - Invited plenary speaker, European Spallation Source Science & Scientists Meeting. Building the ESS - scientific possibilities for life science and soft condensed matter research
  • 2013: Grenoble, France - Invited lecturer, EMBO Practical Course on Small Angle Neutron and X-ray Scattering from Proteins in Solution. Complementary use of AUC for SAXS and SANS
  • 2013: Lund, Sweden - Invited speaker, European Spallation Source Symposium on Neutrons and Life Sciences. Architecture of human pyruvate dehydrogenase complex determined with SAXS, SANS and AUC
  • 2013: Atami, Japan - Session chair and organising committee member, AUC 2013 - 21st International AUC Conference
  • 2012: Geesthacht, Germany - Invited speaker, Helmholtz-Zentrum. Architecture of human pyruvate dehydrogenase complex determined with SAXS, SANS and AUC
  • 2012: Hyderabad, India - Invited lecturer, EMBO Global Exchange Lecture Course on Structural and Biophysical Methods for Biological Macromolecules in solution. Joint applications of SAXS/SANS and hydrodynamic methods in the studies of biomacromolecular solutions
  • 2012: Hamburg, Germany - Invited lecturer, EMBO Practical Course on solution scattering from biological macromolecules. Joint use of SAS and AUC
  • 2012: San Antonio, Texas, USA - Session chair, 20th International AUC Conference
  • 2012: Hamburg, Germany - Invited speaker, HASYLAB. SAUCE: Scattering-Analytical Ultracentrifuge Equipment - a new hybrid instrument for new biomolecular and polymer science
  • 2012: Lund, Sweden - Invited speaker, ESS Symposium “The Future of Soft Matter SANS: Consequences for Sample Environment and Complementary Techniques”. Neutron scattering and complementary techniques
  • 2011: Beijing, China - Invited speaker, Institute of High Energy Physics. Understanding the structure of drug target macromolecules though combined biophysical approaches
  • 2011: Bad Reichenhall, Germany - Invited speaker, ESS Science Workshop "Science Visions for the European Spallation Source". Research with neutrons in biology: future opportunities at the ESS
  • 2011: Beijing, China - Invited lecturer and session chair, EMBO Global Exchange Lecture Course on Structural and Biophysical Methods for Biological Macromolecules in solution. The use of small-angle x-ray scattering with biophysical methods
  • 2011: Madrid, Spain - Invited speaker, XXII Congress and General Assembly of the International Union of Crystallography (IUCr). Unique insights into PDC from neutron scattering
  • 2010: Grenoble, France - Session chair, "ILL2020 Vision"
  • 2010: Grenoble, France - Invited speaker, "Molecules and membranes: the shape of things to come". Protein complex formation studied by SANS and AUC - what works (and what doesn't!)
  • 2010: Grenoble, France - Session chair, "ILL2020 Vision"
  • 2009: Uppsala, Sweden - Organising committee member, AUC 2009
  • 2009: Vienna, Austria - Invited speaker, University of Vienna. The architecture of macromolecular complexes revealed by analytical ultracentrifugation (AUC) and small angle X-ray and neutron scattering (SAXS & SANS)
  • 2008: Hamburg, Germany - Invited speaker, INSTRUCT Workshop. AUC - Analytical UltraCentrifugation And Universally Complementary
  • 2008: Newcastle, UK - Scientific advisory committee member, AUC 2008
  • 2008: Hamburg, Germany - Invited lecturer and session chair, EMBO Practical Course on solution scattering from biological macromolecules. The use of small-angle scattering with biophysical methods
  • 2007: Regensburg, Germany - Invited speaker, University of Regensburg. Characterisation of DNA triplex formation in an oncogene suppression strategy
  • 2007: Hannover, Germany - Scientific advisory committee member, 16th International Analytical Ultracentrifugation Symposium
  • 2006: Aarhus, Denmark - Invited speaker, University of Aarhus. Small-angle scattering and analytical ultracentrifugation studies of the solution architecture of protein-DNA complexes
  • 2006: Zuoz, Switzerland - Scientific advisory committee member, 5th PSI Summer School on Condensed
  • 2006: Hamburg, Germany - Invited lecturer and session chair, EMBO Practical Course on solution scattering from biological macromolecules. The use of small-angle scattering with biophysical methods
  • 2005: Boston, Massachusetts, USA - Invited speaker, American Vacuum Society Meeting. Small-angle neutron scattering: a high resolution, non-destructive probe of biomacromolecular structure
  • 2005: Lausanne, Switzerland - Invited speaker and session chair, 14th International Symposium on Analytical Ultracentrifugation: AUC2005. Assembly of subcomplexes of protein dehydrogenase complex determined by AUC and SAS
  • 2005: Berlin, Germany - Invited plenary speaker, German Physical Society Meeting. The impact of neutrons on biological systems
  • 2004: Hamburg, Germany - Invited lecturer, EMBO Practical Course on solution scattering from biological macromolecules. The use of small-angle scattering with biophysical methods
  • 2002: Austin, USA - Invited speaker, Association of Biomolecular Resource Facilities Meeting. The MIRG 2002 study: Assembly state, thermodynamic and kinetic analysis of an enzyme/inhibitor interaction
  • 2002: Austin, USA - Invited contributor, Association of Biomolecular Resource Facilities Meeting. Roundtable discussion: Technologies for determining affinities of molecular interactions
  • 2002: Bonn, Germany - Invited plenary speaker, European Spallation Source Meeting. Inside the cell
  • 2002: Autrans, France - Session chair, scientific advisory committee and organisation committee member, "Advances in Analytical Ultracentrifugation and Hydrodynamics"
  • 2002: Ventura, USA - Session chair, Gordon Research Conference on Reversible Associations in Structural and Molecular Biology
  • 2000: Ventura, USA - Poster co-chair, Gordon Research Conference on Reversible Associations in Structural and Molecular Biology
  • 2000: Glasgow, UK - Organiser, 6th UK AUC Users' Meeting (HYDRO 2000)
  • 1999: Potsdam, Germany - Invited speaker and session co-chair, XIth Symposium on Analytical Ultracentrifugation. The structural organisation of the Lon protease of E. coli revealed in the analytical ultracentrifuge
  • 1998: Seattle, USA - Invited speaker and session co-chair, 2nd Beckman Symposium on the Solution Interactions of Macromolecules. The solution structure of glycoproteins observed with AUC and SANS
  • 1997: Galveston, USA - Invited speaker, 1st Beckman Symposium on the Solution Interactions of Macromolecules. Defining structural models consistent with hydrodynamic data.
  • 1997: Regensburg, Germany - Invited speaker, Xth Symposium on Analytical Ultracentrifugation. Characterisation of DNA triplex formation in an oncogene suppression strategy
  • 1997: Zuoz, Switzerland - Invited tutor, 5th Summer School on Neutron Scattering. Elastic neutron scattering and hydrodynamics: highly complementary methods for studying biological macromolecular systems
  • 1996: Baltimore, USA - Invited speaker, Advances in Sedimentation Analysis Workshop. Modelling conformations and interactions using sedimentation velocity data.
  • 1996: Leicester, UK - Organiser, 4th UK AUC Users' Group Meeting
  • 1996: Zurich, Switzerland - Invited speaker, ETH. Modelling biopolymer structures in solution
  • 1995: Davos, Switzerland - Protein Society Symposium. Macromolecular solution conformations from hydrodynamic bead modelling studies.
  • 1995: Berlin, Germany - Invited speaker, IXth Symposium on Analytical Ultracentrifugation. Hydrodynamic modelling of macromolecular structures
  • 1995: Storrs, USA - Invited speaker, Workshop in Analytical Ultracentrifugation. A straightforward route to the study and modelling of association via analytical ultracentrifugation.
  • 1995: Murcia, Spain - Invited speaker, Universidad de Murcia. From atoms to beads and beyond.
  • 1994: Leicester, UK - Organiser, "The Production of Recombinant Proteins in Plants"
  • 1994: Leicester, UK - UK - Organiser, 3rd UK AUC Users' Group Meeting
  • 1993: Leicester, UK - Organiser, 2nd UK Analytical Ultracentrifuge Users' Group Meeting
  • 1993: Leicester, UK - Organiser, "Size, Shape & Interaction"

Professional Learned Society

  • 2003 - ongoing: Biophysical Society - Member
  • 1988 - ongoing: British Biochemical Society - Techniques Group Committee, 1998-2003
  • 1988 - ongoing: British Biophysical Society - Member

Publications

List by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993
Number of items: 68.

2016

Ashraf, K. U., Josts, I., Mosbahi, K., Kelly, S. M., Byron, O., Smith, B. O., and Walker, D. (2016) The potassium binding protein Kbp is a cytoplasmic potassium sensor. Structure, 24(5), pp. 741-749. (doi:10.1016/j.str.2016.03.017) (PMID:27112601)

2015

Byron, O., and Vestergaard, B. (2015) Protein–protein interactions: a supra-structural phenomenon demanding trans-disciplinary biophysical approaches. Current Opinion in Structural Biology, 35, pp. 76-86. (doi:10.1016/j.sbi.2015.09.003)

Rocco, M., and Byron, O. (2015) Computing translational diffusion and sedimentation coefficients: an evaluation of experimental data and programs. European Biophysics Journal, 44(6), pp. 417-431. (doi:10.1007/s00249-015-1042-9)

Rocco, M., and Byron, O. (2015) Erratum to: Computing translational diffusion and sedimentation coefficients: an evaluation of experimental data and programs. European Biophysics Journal, 44(6), pp. 433-436. (doi:10.1007/s00249-015-1058-1) (PMID:26187588)

Joshi, A. et al. (2015) Structures of the ultra-high-affinity protein–protein complexes of pyocins S2 and AP41 and their cognate immunity proteins from pseudomonas aeruginosa. Journal of Molecular Biology, 427(17), pp. 2852-2866. (doi:10.1016/j.jmb.2015.07.014) (PMID:26215615) (PMCID:PMC4548480)

Fyfe, C.D., Grinter, R., Josts, I., Mosbahi, K., Roszak, A.W., Cogdell, R.J., Wall, D.M., Burchmore, R.J.S., Byron, O., and Walker, D. (2015) Structure of protease-cleaved escherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment. Acta Crystallographica. Section D: Biological Crystallography, 71(7), pp. 1478-1486. (doi:10.1107/s1399004715008548) (PMID:26143919) (PMCID:PMC4498604)

Rocco, M., and Byron, O. (2015) Hydrodynamic modeling and its application in AUC. Methods in Enzymology, 562, pp. 81-108. (doi:10.1016/bs.mie.2015.04.010) (PMID:26412648)

Zhao, H. et al. (2015) A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation. PLoS ONE, 10(5), e0126420. (doi:10.1371/journal.pone.0126420) (PMID:25997164) (PMCID:PMC4440767)

2014

English, G., Byron, O., Cianfanelli, F. R., Prescott, A. R., and Coulthurst, S. J. (2014) Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK–TssFG subcomplex. Biochemical Journal, 461(2), pp. 291-304. (doi:10.1042/BJ20131426)

Beckham, K. S.H. et al. (2014) The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7. Molecular Microbiology, 93(1), pp. 199-211. (doi:10.1111/mmi.12651) (PMID:24846743) (PMCID:PMC4249723)

Grinter, R., Josts, I., Zeth, K., Roszak, A. W., McCaughey, L. C., Cogdell, R. J., Milner, J. J., Kelly, S. M., Byron, O., and Walker, D. (2014) Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake. Molecular Microbiology, 93(2), pp. 234-246. (doi:10.1111/mmi.12655)

Mccaughey, L. C. et al. (2014) Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor. PLoS Pathogens, 10(2), e1003898. (doi:10.1371/journal.ppat.1003898)

Dow, J.M., Grahl, S., Ward, R., Evans, R., Byron, O., Norman, D.G., Palmer, T., and Sargent, F. (2014) Characterization of a periplasmic nitrate reductase in complex with its biosynthetic chaperone. FEBS Journal, 281(1), pp. 246-260. (doi:10.1111/febs.12592)

Josts, I., Grinter, R., Kelly, S. M., Mosbahi, K., Roszak, A., Cogdell, R., Smith, B. O., Byron, O., and Walker, D. (2014) Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal DUF490963–1138 domain of TamB from Escherichia coli. Acta Crystallographica. Section F: Structural Biology Communications, 70(9), pp. 1272-1275. (doi:10.1107/S2053230X14017403)

Laine, L. M., Biddau, M., Byron, O., and Müller, S. (2014) Biochemical and structural characterisation of the apicoplast dihydrolipoamide dehydrogenase of Plasmodium falciparum. Bioscience Reports, 35(1), e00171. (doi:10.1042/BSR20140150) (PMID:25387830) (PMCID:PMC4293902)

2013

Rocco, M., Brookes, E., and Byron, O. (2013) US-SOMO: methods for construction and hydration of macromolecular hydrodynamic models. In: Roberts, G.K. (ed.) Encyclopedia of Biophysics. Springer, pp. 2707-2714. ISBN 9783642167126 (doi:10.1007/978-3-642-16712-6_292)

2012

Beckham, K. S.H., Byron, O., Roe, A. J., and Gabrielsen, M. (2012) The structure of an orthorhombic crystal form of a 'forced reduced' thiol peroxidase reveals lattice formation aided by the presence of the affinity tag. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 68(5), pp. 522-526. (doi:10.1107/S1744309112011487) (PMID:22691780) (PMCID:PMC3374505)

Gabrielsen, M., Beckham, K.S., Feher, V.A., Zetterstrom, C.E., Wang, D., Muller, S., Elofsson, M., Amaro, R.E., Byron, O., and Roe, A.J. (2012) Structural characterisation of Tpx from yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds. PLoS ONE, 7(2), e32217. (doi:10.1371/journal.pone.0032217)

Gabrielsen, M., Beckham, K.S.H., Cogdell, R.J., Byron, O., and Roe, A.J. (2012) FolX from Pseudomonas aeruginosa is octameric in both crystal and solution. FEBS Letters, 586(8), pp. 1160-1165. (doi:10.1016/j.febslet.2012.03.031)

2011

Rasmussen, L.C.V., Oliveira, C.L.P., Byron, O., Jensen, J.M., Pedersen, J.S., Sperling-Petersen, H.U., and Mortensen, K.K. (2011) Structure and dimerization of translation initiation factor aIF5B in solution. Biochemical and Biophysical Research Communications, 416(1-2), pp. 140-145. (doi:10.1016/j.bbrc.2011.11.012)

Wang, D. et al. (2011) Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds. Journal of Biological Chemistry, 286(34), pp. 29922-29931. (doi:10.1074/jbc.M111.233858)

Vijayakrishnan, S., Callow, P., Nutley, M.A., McGow, D.P., Kropholler, P., Cooper, A., Byron, O., and Lindsay, J.G. (2011) Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly. Biochemical Journal, 437(3), pp. 565-574. (doi:10.1042/BJ20101784)

Moore, V., Kanu, A., Byron, O., Campbell, G., Danson, M.J., Hough, D.J., and Crennell, S.J. (2011) Contribution of inter-subunit interactions to the thermostability of Pyrococcus furiosus citrate synthase. Extremophiles, 15(3), pp. 327-336. (doi:10.1007/s00792-011-0363-6)

2010

Vijayakrishnan, S., Kelly, S.M., Gilbert, R.J.C., Callow, P., Bhella, D., Forsyth, T., Lindsay, J.G., and Byron, O. (2010) Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly. Journal of Molecular Biology, 399(1), pp. 71-93. (doi:10.1016/j.jmb.2010.03.043) (PMID:20361979) (PMCID:PMC2880790)

Cardinali, B., Profumo, A., Aprile, A., Byron, O., Morris, G., Harding, S.E., Stafford, W.F., and Rocco, M. (2010) Hydrodynamic and mass spectrometry analysis of nearly-intact human fibrinogen, chicken fibrinogen, and of a substantially monodisperse human fibrinogen fragment X. Archives of Biochemistry and Biophysics, 493(2), pp. 157-168. (doi:10.1016/j.abb.2009.10.008)

2009

Kreiner, M., Byron, O., Domingues, D., and van der Walle, C.F. (2009) Oligomerisation and thermal stability of polyvalent integrin [alpha]5[beta]1 ligands. Biophysical Chemistry, 142(1-3), pp. 34-39. (doi:10.1016/j.bpc.2009.03.001)

2008

Byron, O. (2008) Hydrodynamic modeling: The solution conformation of macromolecules and their complexes. In: Correia, J. J. and Detrich, H. W. (eds.) Biophysical Techniques: A Volume of Methods in Cell Biology. Elsevier, pp. 327-373. ISBN 978-0-12-372520-2

2006

Smolle, M., Prior, A.E., Brown, A.E., Cooper, A., Byron, O., and Lindsay, J.G. (2006) A new level of architectural complexity in the human pyruvate dehydrogenase complex. Journal of Biological Chemistry, 281(28), pp. 19772-19780. (doi:10.1074/jbc.M601140200)

Egan, C. et al. (2006) Lack of immunological cross-reactivity between parasite-derived and recombinant forms of ES-62, a secreted protein of Acanthocheilonema viteae. Parasitology, 132, pp. 263-274. (doi:10.1017/S0031182005009005) (PMID:16216137)

2005

Nollmann, M., Byron, O., and Stark, W. (2005) Behavior of Tn3 resolvase in solution and its interaction with res. Biophysical Journal, 89, pp. 1920-1931. (doi:10.1529/biophysj.104.058164)

Nollmann, M., Stark, W., and Byron, O. (2005) A global multi-technique approach to study low-resolution solution structures. Journal of Applied Crystallography, 38, pp. 874-887. (doi:10.1107/S0021889805026191)

Rai, N., Nollmann, M., Spotorno, B., Tassara, G., Byron, O., and Rocco, M. (2005) SOMO(SOlution MOdeler): Differences between X-ray- and NMR-derived bead models suggest a role for side chain flexibility in protein hydrodynamics. Structure, 13, pp. 723-734. (doi:10.1016/j.str.2005.02.012)

2004

Nollmann, M., Gilbert, R., Mitchell, T., Sferrazza, M., and Byron, O. (2004) The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin. Biophysical Journal, 86, pp. 3141-3151.

Nollmann, M., He, J., Byron, O., and Stark, W. (2004) Solution structure of the Tn3 resolvase-crossover site synaptic complex. Molecular Cell, 16, pp. 127-137.

Nollmann, M., Stark, W., and Byron, O. (2004) Low-resolution reconstruction of a synthetic DNA Holliday junction. Biophysical Journal, 86, pp. 3060-3069.

Smolle, M., Hay, R., and Byron, O. (2004) Hydrodynamic bead modelling of the 2 : 1 p50-I kappa B gamma complex. Biophysical Chemistry, 108, pp. 259-271. (doi:10.1016/j.bpc.2003.10.032)

Solovyova, A., Nollmann, M., Mitchell, T., and Byron, O. (2004) The solution structure and oligomerization behavior of two bacterial toxins: Pneumolysin and perfringolysin O. Biophysical Journal, 87, pp. 540-552. (doi:10.1529/biophysj.104.039974)

2003

Myszka, D.G. et al. (2003) The ABRF-MIRG'02 study: assembly state, thermodynamic, and kinetic analysis of an enzyme/inhibitor interaction. Journal of Biomolecular Techniques, 14(4), pp. 247-269.

Ackerman, C., Harnett, M., Harnett, W., Kelly, S., Svergun, D., and Byron, O. (2003) 19 angstrom solution structure of the filarial nematode immunomodulatory protein, ES-62. Biophysical Journal, 84, pp. 489-500.

Fowler, S., Byron, O., Jumel, K., Xing, D., Corbel, M., and Bolgiano, B. (2003) Novel configurations of high molecular weight species of the pertussis toxin vaccine component. Vaccine, 21, pp. 2678-2688. (doi:10.1016/S0264-410X(03)00105-1)

Harnett, W., Harnett, M., and Byron, O. (2003) Structural/functional aspects of ES-62 - A secreted immunomodulatory phosphorylcholine-containing filarial nematode glycoprotein. Current Protein and Peptide Science, 4, pp. 59-71.

Solovyova, A.S., Meenan, N., McDermott, L., Garofalo, A., Bradley, J.E., Kennedy, M.W., and Byron, O. (2003) The polyprotein and FAR lipid binding proteins of nematodes: shape and monomer/dimer states in ligand-free and bound forms. European Biophysics Journal with Biophysics Letters, 32, pp. 465-476. (doi:10.1007/s00249-003-0297-8)

2002

Scott, D., Grossmann, J., Tames, J., Byron, O., Wilson, K., and Otto, B. (2002) Low resolution solution structure of the apo form of Escherichia coli haemoglobin protease Hbp. Journal of Molecular Biology, 315, pp. 1179-1187. (doi:10.1006/jmbi.2001.5306)

2001

Kim, M., Sun, Z.-Y. J., Byron, O., Campbell, G., Wagner, G., Wang, J.-h., and Reinherz, E. L. (2001) Molecular dissection of the CD2-C58 counter-receptor interface identifies CD2 Tyr86 and CD58 Lys34 residues as the functional 'hot spot'. Journal of Molecular Biology, 312(4), pp. 711-720. (doi:10.1006/jmbi.2001.4980) (PMID:11575926)

Atanasiu, C., Byron, O., McMiken, H., Sturrock, S., and Dryden, D. (2001) Characterisation of the structure of ocr, the gene 0.3 protein of bacteriophage T7. Nucleic Acids Research, 29, pp. 3059-3068.

Bonev, B., Gilbert, R., Andrew, P., Byron, O., and Watts, A. (2001) Structural analysis of the protein/lipid complexes associated with pore formation by the bacterial toxin pneumolysin. Journal of Biological Chemistry, 276, pp. 5714-5719.

Kim, M., Chen, B., Hussey, R., Chishti, Y., Montefiori, D., Hoxie, J., Byron, O., Campbell, G., Harrison, S., and Reinherz, E. (2001) The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. Journal of Biological Chemistry, 276, pp. 42667-42676.

Kim, M., Sun, Z., Byron, O., Campbell, G., Wagner, G., Wang, J., and Reinherz, E. (2001) Molecular dissection of the CD2-CD58 counter-receptor interface identifies CD2 Tyr86 and CD58 Lys34 residues as the functional "hot spot". Journal of Molecular Biology, 312, pp. 711-720.

Short, B., Preisinger, C., Korner, R., Kopajtich, R., Byron, O., and Barr, F. (2001) A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. Journal of Cell Biology, 155, pp. 877-883.

2000

Marfatia, S. M., Byron, O., Campbell, G., Liu, S.-C., and Chishti, A. H. (2000) Human homologue of the drosophila discs large tumor suppressor protein forms an oligomer in solution. IDENTIFICATION OF THE SELF-ASSOCIATION SITE. Journal of Biological Chemistry, 275(18), pp. 13759-13770. (doi:10.1074/jbc.275.18.13759) (PMID:10788497)

Byron, O. (2000) Hydrodynamic bead modeling of biological macromolecules. Methods in Enzymology, 321, pp. 278-304. (doi:10.1016/S0076-6879(00)21199-3) (PMID:10909063)

1999

Carrasco, B., de la Torre, J. G., Byron, O., King, D., Walters, C., Jones, S., and Harding, S. E. (1999) Novel size-independent modeling of the dilute solution conformation of the immunoglobulin IgG Fab′ domain using SOLPRO and ELLIPS. Biophysical Journal, 77(6), pp. 2902-2910. (doi:10.1016/S0006-3495(99)77123-7) (PMID:10585914) (PMCID:PMC1300563)

Gilbert, R. J.C., Heenan, R. K., Timmins, P. A., Gingles, N. A., Mitchell, T. J., Rowe, A. J., Rossjohn, J., Parker, M. W., Andrew, P. W., and Byron, O. (1999) Studies on the structure and mechanism of a bacterial protein toxin by analytical ultracentrifugation and small-angle neutron scattering. Journal of Molecular Biology, 293(5), pp. 1145-1160. (doi:10.1006/jmbi.1999.3210) (PMID:10547292)

Bayliss, R. I., Errington, N., Byron, O., Svensson, A., and Rowe, A. (1999) A conformation spectrum analysis of the morphological states of myosin S1 in the presence of effectors. Progress in Colloid and Polymer Science, 113, pp. 158-163. (doi:10.1007/3-540-48703-4_22)

Errington, N., Byron, O., and Rowe, A. J. (1999) Conformational spectra — probing protein conformational changes. Biophysical Chemistry, 80(3), pp. 189-197. (doi:10.1016/S0301-4622(99)00077-0) (PMID:17030326)

1998

Gilbert, R. J.C., Rossjohn, J., Parker, M. W., Tweten, R. K., Morgan, P. J., Mitchell, T. J., Errington, N., Rowe, A. J., Andrew, P. W., and Byron, O. (1998) Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae. Journal of Molecular Biology, 284(4), pp. 1223-1237. (doi:10.1006/jmbi.1998.2258) (PMID:9837740)

Nairn, J., Duncan, D., Gray, L. M., Urquhart, G., Binnie, M., Byron, O., Fothergill-Gilmore, L. A., and Price, N. C. (1998) Purification and characterization of pyruvate kinase from schizosaccharomyces pombe: evidence for an unusual quaternary structure. Protein Expression and Purification, 14(2), pp. 247-253. (doi:10.1006/prep.1998.0938) (PMID:9790887)

1997

Tharia, H. A., Rowe, A., Byron, O., and Wells, C. (1997) Physical characterization and ATPase activity of 14S dynein fractions from tetrahymena thermophila. Journal of Muscle Research and Cell Motility, 18(6), pp. 697-709. (PMID:9429162)

Marfatia, S. M., Morais-Cabral, J. H., Kim, A. C., Byron, O., and Chishti, A. H. (1997) The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C: analysis of the binding interface by in vitromutagenesis. Journal of Biological Chemistry, 272(39), pp. 24191-24197. (doi:10.1074/jbc.272.39.24191) (PMID:9305870)

Byron, O., Mistry, P., Suter, D., and Skelly, J. (1997) DT diaphorase exists as a dimer-tetramer equilibrium in solution. European Biophysics Journal with Biophysics Letters, 25(5-6), pp. 423-430. (doi:10.1007/s002490050056) (PMID:9188164)

Dryden, D. T. F., Cooper, L. P., Thorpe, P. H., and Byron, O. (1997) The in vitro assembly of the EcoKI Type I DNA restriction/modification enzyme and its in vivo implications. Biochemistry, 36(5), pp. 1065-1076. (doi:10.1021/bi9619435) (PMID:9033396)

Byron, O. (1997) Construction of hydrodynamic bead models from high-resolution X-ray crystallographic or nuclear magnetic resonance data. Biophysical Journal, 72(1), pp. 408-415. (doi:10.1016/S0006-3495(97)78681-8) (PMID:8994627) (PMCID:PMC1184331)

1996

Brownleader, M. D., Byron, O., Rowe, A., Trevan, M., Welhan, K., and Dey, P. M. (1996) Investigations into the molecular size and shape of tomato extensin. Biochemical Journal, 320(2), pp. 577-583. (doi:10.1042/bj3200577)

Cabral, J. H. M., Petosa, C., Sutcliffe, M. J., Raza, S., Byron, O., Poy, F., Marfatia, S. M., Chishti, A. H., and Liddington, R. C. (1996) Crystal structure of a PDZ domain. Nature, 382(6592), pp. 649-652. (doi:10.1038/382649a0) (PMID:8757139)

1995

Silkowski, H., Davis, S. J., Barclay, A. N., Rowe, A. J., Harding, S. E., and Byron, O. (1995) Characterisation of the low affinity interaction between rat cell adhesion molecules CD2 and CD48 by analytical ultracentrifugation. European Biophysics Journal with Biophysics Letters, 25(5-6), pp. 455-462. (doi:10.1007/s002490050060) (PMID:9188168)

Byron, O. (1995) Hydrodynamic modelling of the solution conformation of 10 S myosin. In: Behlke, J. (ed.) Analytical Ultracentrifugation. Series: Progress in colloid and polymer science (99). Steinkopff: Darmstadt, pp. 82-86. ISBN 9783798510388 (doi:10.1007/BFb0114074)

1994

Morgan, P. J., Hyman, S. C., Byron, O., Andrew, P. W., Mitchell, T. J., and Rowe, A. J. (1994) Modeling the bacterial protein toxin, pneumolysin, in its monomeric and oligomeric form. Journal of Biological Chemistry, 269(41), pp. 25315-20. (PMID:7929224)

1993

King, D. J. et al. (1993) Expression, purification and characterization of B72.3 Fv fragments. Biochemical Journal, 290(3), pp. 723-729. (doi:10.1042/bj2900723) (PMID:8457200)

This list was generated on Tue Aug 23 09:05:51 2016 BST.
Number of items: 68.

Articles

Ashraf, K. U., Josts, I., Mosbahi, K., Kelly, S. M., Byron, O., Smith, B. O., and Walker, D. (2016) The potassium binding protein Kbp is a cytoplasmic potassium sensor. Structure, 24(5), pp. 741-749. (doi:10.1016/j.str.2016.03.017) (PMID:27112601)

Byron, O., and Vestergaard, B. (2015) Protein–protein interactions: a supra-structural phenomenon demanding trans-disciplinary biophysical approaches. Current Opinion in Structural Biology, 35, pp. 76-86. (doi:10.1016/j.sbi.2015.09.003)

Rocco, M., and Byron, O. (2015) Computing translational diffusion and sedimentation coefficients: an evaluation of experimental data and programs. European Biophysics Journal, 44(6), pp. 417-431. (doi:10.1007/s00249-015-1042-9)

Rocco, M., and Byron, O. (2015) Erratum to: Computing translational diffusion and sedimentation coefficients: an evaluation of experimental data and programs. European Biophysics Journal, 44(6), pp. 433-436. (doi:10.1007/s00249-015-1058-1) (PMID:26187588)

Joshi, A. et al. (2015) Structures of the ultra-high-affinity protein–protein complexes of pyocins S2 and AP41 and their cognate immunity proteins from pseudomonas aeruginosa. Journal of Molecular Biology, 427(17), pp. 2852-2866. (doi:10.1016/j.jmb.2015.07.014) (PMID:26215615) (PMCID:PMC4548480)

Fyfe, C.D., Grinter, R., Josts, I., Mosbahi, K., Roszak, A.W., Cogdell, R.J., Wall, D.M., Burchmore, R.J.S., Byron, O., and Walker, D. (2015) Structure of protease-cleaved escherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment. Acta Crystallographica. Section D: Biological Crystallography, 71(7), pp. 1478-1486. (doi:10.1107/s1399004715008548) (PMID:26143919) (PMCID:PMC4498604)

Rocco, M., and Byron, O. (2015) Hydrodynamic modeling and its application in AUC. Methods in Enzymology, 562, pp. 81-108. (doi:10.1016/bs.mie.2015.04.010) (PMID:26412648)

Zhao, H. et al. (2015) A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation. PLoS ONE, 10(5), e0126420. (doi:10.1371/journal.pone.0126420) (PMID:25997164) (PMCID:PMC4440767)

English, G., Byron, O., Cianfanelli, F. R., Prescott, A. R., and Coulthurst, S. J. (2014) Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK–TssFG subcomplex. Biochemical Journal, 461(2), pp. 291-304. (doi:10.1042/BJ20131426)

Beckham, K. S.H. et al. (2014) The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7. Molecular Microbiology, 93(1), pp. 199-211. (doi:10.1111/mmi.12651) (PMID:24846743) (PMCID:PMC4249723)

Grinter, R., Josts, I., Zeth, K., Roszak, A. W., McCaughey, L. C., Cogdell, R. J., Milner, J. J., Kelly, S. M., Byron, O., and Walker, D. (2014) Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake. Molecular Microbiology, 93(2), pp. 234-246. (doi:10.1111/mmi.12655)

Mccaughey, L. C. et al. (2014) Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor. PLoS Pathogens, 10(2), e1003898. (doi:10.1371/journal.ppat.1003898)

Dow, J.M., Grahl, S., Ward, R., Evans, R., Byron, O., Norman, D.G., Palmer, T., and Sargent, F. (2014) Characterization of a periplasmic nitrate reductase in complex with its biosynthetic chaperone. FEBS Journal, 281(1), pp. 246-260. (doi:10.1111/febs.12592)

Josts, I., Grinter, R., Kelly, S. M., Mosbahi, K., Roszak, A., Cogdell, R., Smith, B. O., Byron, O., and Walker, D. (2014) Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal DUF490963–1138 domain of TamB from Escherichia coli. Acta Crystallographica. Section F: Structural Biology Communications, 70(9), pp. 1272-1275. (doi:10.1107/S2053230X14017403)

Laine, L. M., Biddau, M., Byron, O., and Müller, S. (2014) Biochemical and structural characterisation of the apicoplast dihydrolipoamide dehydrogenase of Plasmodium falciparum. Bioscience Reports, 35(1), e00171. (doi:10.1042/BSR20140150) (PMID:25387830) (PMCID:PMC4293902)

Beckham, K. S.H., Byron, O., Roe, A. J., and Gabrielsen, M. (2012) The structure of an orthorhombic crystal form of a 'forced reduced' thiol peroxidase reveals lattice formation aided by the presence of the affinity tag. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 68(5), pp. 522-526. (doi:10.1107/S1744309112011487) (PMID:22691780) (PMCID:PMC3374505)

Gabrielsen, M., Beckham, K.S., Feher, V.A., Zetterstrom, C.E., Wang, D., Muller, S., Elofsson, M., Amaro, R.E., Byron, O., and Roe, A.J. (2012) Structural characterisation of Tpx from yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds. PLoS ONE, 7(2), e32217. (doi:10.1371/journal.pone.0032217)

Gabrielsen, M., Beckham, K.S.H., Cogdell, R.J., Byron, O., and Roe, A.J. (2012) FolX from Pseudomonas aeruginosa is octameric in both crystal and solution. FEBS Letters, 586(8), pp. 1160-1165. (doi:10.1016/j.febslet.2012.03.031)

Rasmussen, L.C.V., Oliveira, C.L.P., Byron, O., Jensen, J.M., Pedersen, J.S., Sperling-Petersen, H.U., and Mortensen, K.K. (2011) Structure and dimerization of translation initiation factor aIF5B in solution. Biochemical and Biophysical Research Communications, 416(1-2), pp. 140-145. (doi:10.1016/j.bbrc.2011.11.012)

Wang, D. et al. (2011) Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds. Journal of Biological Chemistry, 286(34), pp. 29922-29931. (doi:10.1074/jbc.M111.233858)

Vijayakrishnan, S., Callow, P., Nutley, M.A., McGow, D.P., Kropholler, P., Cooper, A., Byron, O., and Lindsay, J.G. (2011) Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly. Biochemical Journal, 437(3), pp. 565-574. (doi:10.1042/BJ20101784)

Moore, V., Kanu, A., Byron, O., Campbell, G., Danson, M.J., Hough, D.J., and Crennell, S.J. (2011) Contribution of inter-subunit interactions to the thermostability of Pyrococcus furiosus citrate synthase. Extremophiles, 15(3), pp. 327-336. (doi:10.1007/s00792-011-0363-6)

Vijayakrishnan, S., Kelly, S.M., Gilbert, R.J.C., Callow, P., Bhella, D., Forsyth, T., Lindsay, J.G., and Byron, O. (2010) Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly. Journal of Molecular Biology, 399(1), pp. 71-93. (doi:10.1016/j.jmb.2010.03.043) (PMID:20361979) (PMCID:PMC2880790)

Cardinali, B., Profumo, A., Aprile, A., Byron, O., Morris, G., Harding, S.E., Stafford, W.F., and Rocco, M. (2010) Hydrodynamic and mass spectrometry analysis of nearly-intact human fibrinogen, chicken fibrinogen, and of a substantially monodisperse human fibrinogen fragment X. Archives of Biochemistry and Biophysics, 493(2), pp. 157-168. (doi:10.1016/j.abb.2009.10.008)

Kreiner, M., Byron, O., Domingues, D., and van der Walle, C.F. (2009) Oligomerisation and thermal stability of polyvalent integrin [alpha]5[beta]1 ligands. Biophysical Chemistry, 142(1-3), pp. 34-39. (doi:10.1016/j.bpc.2009.03.001)

Smolle, M., Prior, A.E., Brown, A.E., Cooper, A., Byron, O., and Lindsay, J.G. (2006) A new level of architectural complexity in the human pyruvate dehydrogenase complex. Journal of Biological Chemistry, 281(28), pp. 19772-19780. (doi:10.1074/jbc.M601140200)

Egan, C. et al. (2006) Lack of immunological cross-reactivity between parasite-derived and recombinant forms of ES-62, a secreted protein of Acanthocheilonema viteae. Parasitology, 132, pp. 263-274. (doi:10.1017/S0031182005009005) (PMID:16216137)

Nollmann, M., Byron, O., and Stark, W. (2005) Behavior of Tn3 resolvase in solution and its interaction with res. Biophysical Journal, 89, pp. 1920-1931. (doi:10.1529/biophysj.104.058164)

Nollmann, M., Stark, W., and Byron, O. (2005) A global multi-technique approach to study low-resolution solution structures. Journal of Applied Crystallography, 38, pp. 874-887. (doi:10.1107/S0021889805026191)

Rai, N., Nollmann, M., Spotorno, B., Tassara, G., Byron, O., and Rocco, M. (2005) SOMO(SOlution MOdeler): Differences between X-ray- and NMR-derived bead models suggest a role for side chain flexibility in protein hydrodynamics. Structure, 13, pp. 723-734. (doi:10.1016/j.str.2005.02.012)

Nollmann, M., Gilbert, R., Mitchell, T., Sferrazza, M., and Byron, O. (2004) The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin. Biophysical Journal, 86, pp. 3141-3151.

Nollmann, M., He, J., Byron, O., and Stark, W. (2004) Solution structure of the Tn3 resolvase-crossover site synaptic complex. Molecular Cell, 16, pp. 127-137.

Nollmann, M., Stark, W., and Byron, O. (2004) Low-resolution reconstruction of a synthetic DNA Holliday junction. Biophysical Journal, 86, pp. 3060-3069.

Smolle, M., Hay, R., and Byron, O. (2004) Hydrodynamic bead modelling of the 2 : 1 p50-I kappa B gamma complex. Biophysical Chemistry, 108, pp. 259-271. (doi:10.1016/j.bpc.2003.10.032)

Solovyova, A., Nollmann, M., Mitchell, T., and Byron, O. (2004) The solution structure and oligomerization behavior of two bacterial toxins: Pneumolysin and perfringolysin O. Biophysical Journal, 87, pp. 540-552. (doi:10.1529/biophysj.104.039974)

Myszka, D.G. et al. (2003) The ABRF-MIRG'02 study: assembly state, thermodynamic, and kinetic analysis of an enzyme/inhibitor interaction. Journal of Biomolecular Techniques, 14(4), pp. 247-269.

Ackerman, C., Harnett, M., Harnett, W., Kelly, S., Svergun, D., and Byron, O. (2003) 19 angstrom solution structure of the filarial nematode immunomodulatory protein, ES-62. Biophysical Journal, 84, pp. 489-500.

Fowler, S., Byron, O., Jumel, K., Xing, D., Corbel, M., and Bolgiano, B. (2003) Novel configurations of high molecular weight species of the pertussis toxin vaccine component. Vaccine, 21, pp. 2678-2688. (doi:10.1016/S0264-410X(03)00105-1)

Harnett, W., Harnett, M., and Byron, O. (2003) Structural/functional aspects of ES-62 - A secreted immunomodulatory phosphorylcholine-containing filarial nematode glycoprotein. Current Protein and Peptide Science, 4, pp. 59-71.

Solovyova, A.S., Meenan, N., McDermott, L., Garofalo, A., Bradley, J.E., Kennedy, M.W., and Byron, O. (2003) The polyprotein and FAR lipid binding proteins of nematodes: shape and monomer/dimer states in ligand-free and bound forms. European Biophysics Journal with Biophysics Letters, 32, pp. 465-476. (doi:10.1007/s00249-003-0297-8)

Scott, D., Grossmann, J., Tames, J., Byron, O., Wilson, K., and Otto, B. (2002) Low resolution solution structure of the apo form of Escherichia coli haemoglobin protease Hbp. Journal of Molecular Biology, 315, pp. 1179-1187. (doi:10.1006/jmbi.2001.5306)

Kim, M., Sun, Z.-Y. J., Byron, O., Campbell, G., Wagner, G., Wang, J.-h., and Reinherz, E. L. (2001) Molecular dissection of the CD2-C58 counter-receptor interface identifies CD2 Tyr86 and CD58 Lys34 residues as the functional 'hot spot'. Journal of Molecular Biology, 312(4), pp. 711-720. (doi:10.1006/jmbi.2001.4980) (PMID:11575926)

Atanasiu, C., Byron, O., McMiken, H., Sturrock, S., and Dryden, D. (2001) Characterisation of the structure of ocr, the gene 0.3 protein of bacteriophage T7. Nucleic Acids Research, 29, pp. 3059-3068.

Bonev, B., Gilbert, R., Andrew, P., Byron, O., and Watts, A. (2001) Structural analysis of the protein/lipid complexes associated with pore formation by the bacterial toxin pneumolysin. Journal of Biological Chemistry, 276, pp. 5714-5719.

Kim, M., Chen, B., Hussey, R., Chishti, Y., Montefiori, D., Hoxie, J., Byron, O., Campbell, G., Harrison, S., and Reinherz, E. (2001) The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. Journal of Biological Chemistry, 276, pp. 42667-42676.

Kim, M., Sun, Z., Byron, O., Campbell, G., Wagner, G., Wang, J., and Reinherz, E. (2001) Molecular dissection of the CD2-CD58 counter-receptor interface identifies CD2 Tyr86 and CD58 Lys34 residues as the functional "hot spot". Journal of Molecular Biology, 312, pp. 711-720.

Short, B., Preisinger, C., Korner, R., Kopajtich, R., Byron, O., and Barr, F. (2001) A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. Journal of Cell Biology, 155, pp. 877-883.

Marfatia, S. M., Byron, O., Campbell, G., Liu, S.-C., and Chishti, A. H. (2000) Human homologue of the drosophila discs large tumor suppressor protein forms an oligomer in solution. IDENTIFICATION OF THE SELF-ASSOCIATION SITE. Journal of Biological Chemistry, 275(18), pp. 13759-13770. (doi:10.1074/jbc.275.18.13759) (PMID:10788497)

Byron, O. (2000) Hydrodynamic bead modeling of biological macromolecules. Methods in Enzymology, 321, pp. 278-304. (doi:10.1016/S0076-6879(00)21199-3) (PMID:10909063)

Carrasco, B., de la Torre, J. G., Byron, O., King, D., Walters, C., Jones, S., and Harding, S. E. (1999) Novel size-independent modeling of the dilute solution conformation of the immunoglobulin IgG Fab′ domain using SOLPRO and ELLIPS. Biophysical Journal, 77(6), pp. 2902-2910. (doi:10.1016/S0006-3495(99)77123-7) (PMID:10585914) (PMCID:PMC1300563)

Gilbert, R. J.C., Heenan, R. K., Timmins, P. A., Gingles, N. A., Mitchell, T. J., Rowe, A. J., Rossjohn, J., Parker, M. W., Andrew, P. W., and Byron, O. (1999) Studies on the structure and mechanism of a bacterial protein toxin by analytical ultracentrifugation and small-angle neutron scattering. Journal of Molecular Biology, 293(5), pp. 1145-1160. (doi:10.1006/jmbi.1999.3210) (PMID:10547292)

Bayliss, R. I., Errington, N., Byron, O., Svensson, A., and Rowe, A. (1999) A conformation spectrum analysis of the morphological states of myosin S1 in the presence of effectors. Progress in Colloid and Polymer Science, 113, pp. 158-163. (doi:10.1007/3-540-48703-4_22)

Errington, N., Byron, O., and Rowe, A. J. (1999) Conformational spectra — probing protein conformational changes. Biophysical Chemistry, 80(3), pp. 189-197. (doi:10.1016/S0301-4622(99)00077-0) (PMID:17030326)

Gilbert, R. J.C., Rossjohn, J., Parker, M. W., Tweten, R. K., Morgan, P. J., Mitchell, T. J., Errington, N., Rowe, A. J., Andrew, P. W., and Byron, O. (1998) Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae. Journal of Molecular Biology, 284(4), pp. 1223-1237. (doi:10.1006/jmbi.1998.2258) (PMID:9837740)

Nairn, J., Duncan, D., Gray, L. M., Urquhart, G., Binnie, M., Byron, O., Fothergill-Gilmore, L. A., and Price, N. C. (1998) Purification and characterization of pyruvate kinase from schizosaccharomyces pombe: evidence for an unusual quaternary structure. Protein Expression and Purification, 14(2), pp. 247-253. (doi:10.1006/prep.1998.0938) (PMID:9790887)

Tharia, H. A., Rowe, A., Byron, O., and Wells, C. (1997) Physical characterization and ATPase activity of 14S dynein fractions from tetrahymena thermophila. Journal of Muscle Research and Cell Motility, 18(6), pp. 697-709. (PMID:9429162)

Marfatia, S. M., Morais-Cabral, J. H., Kim, A. C., Byron, O., and Chishti, A. H. (1997) The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C: analysis of the binding interface by in vitromutagenesis. Journal of Biological Chemistry, 272(39), pp. 24191-24197. (doi:10.1074/jbc.272.39.24191) (PMID:9305870)

Byron, O., Mistry, P., Suter, D., and Skelly, J. (1997) DT diaphorase exists as a dimer-tetramer equilibrium in solution. European Biophysics Journal with Biophysics Letters, 25(5-6), pp. 423-430. (doi:10.1007/s002490050056) (PMID:9188164)

Dryden, D. T. F., Cooper, L. P., Thorpe, P. H., and Byron, O. (1997) The in vitro assembly of the EcoKI Type I DNA restriction/modification enzyme and its in vivo implications. Biochemistry, 36(5), pp. 1065-1076. (doi:10.1021/bi9619435) (PMID:9033396)

Byron, O. (1997) Construction of hydrodynamic bead models from high-resolution X-ray crystallographic or nuclear magnetic resonance data. Biophysical Journal, 72(1), pp. 408-415. (doi:10.1016/S0006-3495(97)78681-8) (PMID:8994627) (PMCID:PMC1184331)

Brownleader, M. D., Byron, O., Rowe, A., Trevan, M., Welhan, K., and Dey, P. M. (1996) Investigations into the molecular size and shape of tomato extensin. Biochemical Journal, 320(2), pp. 577-583. (doi:10.1042/bj3200577)

Cabral, J. H. M., Petosa, C., Sutcliffe, M. J., Raza, S., Byron, O., Poy, F., Marfatia, S. M., Chishti, A. H., and Liddington, R. C. (1996) Crystal structure of a PDZ domain. Nature, 382(6592), pp. 649-652. (doi:10.1038/382649a0) (PMID:8757139)

Silkowski, H., Davis, S. J., Barclay, A. N., Rowe, A. J., Harding, S. E., and Byron, O. (1995) Characterisation of the low affinity interaction between rat cell adhesion molecules CD2 and CD48 by analytical ultracentrifugation. European Biophysics Journal with Biophysics Letters, 25(5-6), pp. 455-462. (doi:10.1007/s002490050060) (PMID:9188168)

Morgan, P. J., Hyman, S. C., Byron, O., Andrew, P. W., Mitchell, T. J., and Rowe, A. J. (1994) Modeling the bacterial protein toxin, pneumolysin, in its monomeric and oligomeric form. Journal of Biological Chemistry, 269(41), pp. 25315-20. (PMID:7929224)

King, D. J. et al. (1993) Expression, purification and characterization of B72.3 Fv fragments. Biochemical Journal, 290(3), pp. 723-729. (doi:10.1042/bj2900723) (PMID:8457200)

Book Sections

Rocco, M., Brookes, E., and Byron, O. (2013) US-SOMO: methods for construction and hydration of macromolecular hydrodynamic models. In: Roberts, G.K. (ed.) Encyclopedia of Biophysics. Springer, pp. 2707-2714. ISBN 9783642167126 (doi:10.1007/978-3-642-16712-6_292)

Byron, O. (2008) Hydrodynamic modeling: The solution conformation of macromolecules and their complexes. In: Correia, J. J. and Detrich, H. W. (eds.) Biophysical Techniques: A Volume of Methods in Cell Biology. Elsevier, pp. 327-373. ISBN 978-0-12-372520-2

Byron, O. (1995) Hydrodynamic modelling of the solution conformation of 10 S myosin. In: Behlke, J. (ed.) Analytical Ultracentrifugation. Series: Progress in colloid and polymer science (99). Steinkopff: Darmstadt, pp. 82-86. ISBN 9783798510388 (doi:10.1007/BFb0114074)

This list was generated on Tue Aug 23 09:05:51 2016 BST.