Allergen proteins from mites

Allergen proteins from mites

While we were working on lipid binding protein allegens from nematodes, we got involved in a collaboration with Leonardo Puerta and Luis Caraballo, University of Cartagena, Colombia, on fatty acid binding protein allergens from the tropical house dust mite, Blomia tropicalis. The Colombian lab has been mutating the proteins in the hope that they might yield materials useful in allergy cures or research. Our part is to help with examining whether the mutations affect the proteins' structure and biochemical activity. This collaboration has now enlarged to include work on a range of allergens of the mite in association with Chew Fook Tim at the University of Singapore. Early days yet, but it looks as though mites may have some unusual versions of fatty acid binding/transporter proteins that we thought were confined to nematodes.