Dr Helen Mulvana
- Lord Kelvin Adam Smith Research Fellow (Systems Power and Energy)
Helen was awarded a BEng (Hons) in Mechanical Engineering (Product Design) from the University of Glasgow in 2001. On graduating she joined Renishaw plc as a Design and Development Engineer before returning to academia in 2003 to study for an EngD in Medical Devices (EPSRC) in the Department of Bioengineering, University of Strathclyde. In 2008, following a year as a Project Leader at TWI Ltd, Helen joined the Faculty of Medicine at Imperial College London as a Post-Doctoral Research Associate. In 2012 she returned to the University of Glasgow where she is currently a Lord Kelvin Adam Smith Fellow based in the School of Engineering.
Helen’s research interests are in the use of ultrasound for therapy, and more specifically the generation of techniques and tools for safe, non-invasive Targeted Drug Delivery (TDD) to treat cancer.
Ultrasound is capable of generating bio-effects in tissues which can be used to develop transient vascular and cellular porosity for localised drug delivery. The technique offers huge potential to treat a wide range of diseases and the principle has been widely demonstrated pre-clinically. Particular success has been achieved with the use of systemically delivered gas microbubbles, which can act to enhance the generation of bio-effects at low ultrasonic (diagnostic) intensities. However, the processes which facilitate ultrasound mediated TDD are not fully understood and this has limited delivery efficiencies and progress towards clinical application.
Helen’s research focuses on developing a better understanding of how ultrasound can be used to generate cellular porosity and the development of improved protocols and devices for improving drug/gene delivery.
Mulvana, H., Stride, E., Hajnal, J.V., and Eckersley, R.J. (2010) Temperature dependent behavior of ultrasound contrast agents. Ultrasound in Medicine and Biology, 36(6), pp. 925-934. (doi:10.1016/j.ultrasmedbio.2010.03.003)
I welcome enquiries from students interested in working with me in the areas of ultrasound mediated targeted drug delivery, medical ultrasound or ultrasound contrast agents.
In addition, I am currently advertising the following PhD projects:
1. A physiologically relevant model for Ultrasound activated Targeted Drug Delivery (TDD).
2. High throughput investigation of ultrasound and microbubble activated drug delivery.
3. The manipulation and activation of microbubble ultrasound contrast agent through Optoelectronic Tweezers (OET) and Surface Acoustic Waves (SAW).
Feel free to contact me for an informal discussion and in addition you can find more information on the School of Engineering website or from the advert on findaphd.com.
Introduction to Biomedical Engineering 1
Cellular Biophysics 4
Advanced Imaging and Therapy 5