Dr Helen Mulvana

  • Lecturer (Systems Power and Energy)

telephone: 01413305044
email: Helen.Mulvana@glasgow.ac.uk

Research interests

My research focuses on the use of ultrasound and contrast ultrasound for the treatment and early diagnosis of disease.

As a mechanical engineer I collaborate with clinicians and researchers in chemistry, life sciences and cell biology.

 

Current projects include

Development of magnetomotive ultrasound elastography imaging for earlier diagnosis of colorectal cancer

Development of physiologically relevant flow phantoms to study ultasound mediated targeted drug delivery

Investigation of ultrasound mediated gene delivery as a means to treat pre-eclampsia during pregnancy

Development of novel ultrasound devices for combined cutting and therapy

Selected publications

Grants

  • ‘Development of non-ionising and non-invasive, personalised colorectal cancer staging using novel multimodal contrast agents and magnetomotive ultrasound imaging’ - Multidisciplinary Project Award, Cancer Research UK, PI (£460k), August 2017 – July 2021.
  • ‘Physiologically and anatomically accurate flow phantom for controlled investigation of ultrasound and microbubble mediated targeted drug delivery’ - Collaborative Research Grant, Carnegie Trust, PI (£45.5k), February 2017 – January 2019.
  • ‘Contrast enhanced ultrasound (ceus) to advance individual staging and treatment planning in rectal cancer’ - Small Grant, Bowel and Cancer Research, co-PI (£49k), August 2017 – July 2019.
  • ‘Microscope based flow phantom for controlled investigation of ultrasound and microbubble targeted drug delivery’ - Research Grant, Royal Society, PI (£15k), March 2016 – March 2018.
  • ‘Custom Bubbles’ - Scottish Crucible Award, Royal Society of Edinburgh, PI (£2.6k)

Supervision

PhD Candidates

Jill Savva

Sonya Frazier 

If you are interested in PhD research on topics related to my work please contact me. 

Teaching

Introduction to Biomedical Engineering 1

Biophysics of Cells and Systems 4

Advanced Imaging and Therapy 5

Coordinator for the Introduction to Biomedical Engineering research seminar series

Additional information

Associate Editor for IEEE Ultrasonics, Ferroelectrics and Frequency Control (https://ieee-uffc.org/publications/transactions-on-uffc/)

Member of the Technical Program Committee for Medical Ultrasound for the IEEE International Ultrasound Symposia 

Co-founder and Chair of Scottish Ultrasound (http://www.scottishultrasound.org.uk/) 

Co-chair of the School of Engineering Athena Swan Self-Assessment Team, awarded Bronze in Octobner 2016 (http://www.gla.ac.uk/schools/engineering/athenaswan/)

Member of the Institute of Physics Physical Acoustics Committee (http://www.iop.org/activity/groups/subject/pa/index.html)

Fellow of the Higher Education Academy

Chartered Engineer through the Institute of Mechanical Engineers

Scottish Crucible participant (2013)

Reviewer for several international journals

All publications

List by: Type | Date

Jump to: 2017 | 2015 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007 | 2006
Number of items: 18.

2017

Mulvana, H., Browning, R. J., Luan, Y., de Jong, N., Tang, M.-X., Eckersley, R. J. and Stride, E. (2017) Characterization of contrast agent microbubbles for ultrasound imaging and therapy research. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 64(1), pp. 232-251. (doi:10.1109/TUFFC.2016.2613991) (PMID:27810805)

2015

Foster, J. S. et al. (2015) Gelation landscape engineering using a multi-reaction supramolecular hydrogelator system. Journal of the American Chemical Society, 137(45), pp. 14236-14239. (doi:10.1021/jacs.5b06988) (PMID:26502267) (PMCID:PMC4655419)

Gourevich, D., Volovick, A., Dogadkin, O., Wang, L., Mulvana, H., Medan, Y., Melzer, A. and Cochran, S. (2015) In vitro investigation of the individual contributions of ultrasound-induced stable and inertial cavitation in targeted drug delivery. Ultrasound in Medicine and Biology, 41(7), pp. 1853-1864. (doi:10.1016/j.ultrasmedbio.2015.03.016) (PMID:25887690)

2013

Mulvana, H., Cochran, S. and Hill, M. (2013) Ultrasound assisted particle and cell manipulation on-chip. Advanced Drug Delivery Reviews, 65(11-12), pp. 1600-1610. (doi:10.1016/j.addr.2013.07.016)

Casey, J., Sennoga, C., Mulvana, H., Hajnal, J.V., Tang, M.-X. and Eckersley, R.J. (2013) Single bubble acoustic characterization and stability measurement of adherent microbubbles. Ultrasound in Medicine and Biology, 39(5), pp. 903-914. (doi:10.1016/j.ultrasmedbio.2012.12.007)

2012

Mulvana, H., Browning, R.J., Tang, M.-X., Hajnal, J.V. and Eckersley, R.J. (2012) Albumin coated microbubble optimization: custom fabrication and comprehensive characterization. Ultrasound in Medicine and Biology, 38(9), pp. 1599-1607. (doi:10.1016/j.ultrasmedbio.2012.05.002)

Browning, R.J., Mulvana, H., Tang, M.-X., Hajnal, J.V., Wells, D.J. and Eckersley, R.J. (2012) Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo. Ultrasound in Medicine and Biology, 38(6), pp. 1067-1077. (doi:10.1016/j.ultrasmedbio.2012.02.020)

Mulvana, H., Stride, E., Tang, M.-X., Hajnal, J.V. and Eckersley, R.J. (2012) The influence of gas saturation on microbubble stability. Ultrasound in Medicine and Biology, 38(6), pp. 1097-1100. (doi:10.1016/j.ultrasmedbio.2012.02.008)

Mulvana, H., Eckersley, R.J., Tang, M.-X., Pankhurst, Q. and Stride, E. (2012) Theoretical and experimental characterisation of magnetic microbubbles. Ultrasound in Medicine and Biology, 38(5), pp. 864-875. (doi:10.1016/j.ultrasmedbio.2012.01.027)

2011

Browning, R.J., Mulvana, H., Tang, M., Hajnal, J.V., Wells, D.J. and Eckersley, R.J. (2011) Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection. Ultrasound in Medicine and Biology, 37(9), pp. 1531-1537. (doi:10.1016/j.ultrasmedbio.2011.05.019)

Mulvana, H., Stride, E., Tang, M., Hajnal, J.V. and Eckersley, R. (2011) Temperature-dependent differences in the nonlinear acoustic behavior of ultrasound contrast agents revealed by high-speed imaging and bulk acoustics. Ultrasound in Medicine and Biology, 37(9), pp. 1509-1517. (doi:10.1016/j.ultrasmedbio.2011.05.020)

Tang, M.-X., Mulvana, H., Gauthier, T., Lim, A.K.P., Cosgrove, D.O., Eckersley, R.J. and Stride, E. (2011) Quantitative contrast-enhanced ultrasound imaging: a review of sources of variability. Interface Focus, 1(4), pp. 520-539. (doi:10.1098/rsfs.2011.0026)

Stride, E., Mulvana, H., Eckersley, R.J., Tang, M.-X. and Pankhurst, Q. (2011) Magnetic microbubbles. In: Thanh, N.T.K. (ed.) Magnetic Nanoparticles: From Fabriation to Clinical Applications. CRC Press: Boca Raton, FL. ISBN 9781439869321

2010

Mulvana, H., Stride, E., Hajnal, J.V. and Eckersley, R.J. (2010) Temperature dependent behavior of ultrasound contrast agents. Ultrasound in Medicine and Biology, 36(6), pp. 925-934. (doi:10.1016/j.ultrasmedbio.2010.03.003)

Mulvana, H., Eckersley, R.J., Browning, R., Hajnal, J.V., Stride, E., Barrack, T., Tang, M., Pankhurst, Q. and Wells, D. (2010) Enhanced Gene Transfection in vivo using Magnetic Localisation of Ultrasound Contrast Agents: Preliminary Results. In: IEEE International Ultrasonics Symposium 2010, San Diego, 11-14 Oct 2010, pp. 670-673. (doi:10.1109/ULTSYM.2010.5935952)

2009

Mulvana, H., Eckersley, R.J. and Stride, E. (2009) Temperature behaviour of ultrasound contrast agents. In: IEEE International Ultrasonics Symposium, Rome, Italy, 20-23 Sept 2009, pp. 1239-1242. (doi:10.1109/ULTSYM.2009.5441522)

2007

Wallace, M.F., Mulvana, H., Marin, P., Mayne, K., Walsh, M.P., Wright, R., Marsh, R., Spence, B., Solomonidis, S. and Cochran, S. (2007) 4F-4 parametric array design and characterisation for underwater sonar and medical strain imaging applications. In: IEEE International Ultrasonics Symposium, New York, USA, 28-31 Oct 2007, pp. 305-308. (doi:10.1109/ULTSYM.2007.87)

2006

Mulvana, H., Parker, M.F., Cochran, S., Spence, B. and Solomonidis, S. (2006) P3E-8 technique for automatic characterisation of an amputee's residual limb. In: IEEE International Ultrasonics Symposium 2006, Vancouver, Canada, 3-6 Oct 2006, pp. 2088-2091. (doi:10.1109/ULTSYM.2006.500)

This list was generated on Tue Sep 19 11:03:40 2017 BST.
Number of items: 18.

Articles

Mulvana, H., Browning, R. J., Luan, Y., de Jong, N., Tang, M.-X., Eckersley, R. J. and Stride, E. (2017) Characterization of contrast agent microbubbles for ultrasound imaging and therapy research. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 64(1), pp. 232-251. (doi:10.1109/TUFFC.2016.2613991) (PMID:27810805)

Foster, J. S. et al. (2015) Gelation landscape engineering using a multi-reaction supramolecular hydrogelator system. Journal of the American Chemical Society, 137(45), pp. 14236-14239. (doi:10.1021/jacs.5b06988) (PMID:26502267) (PMCID:PMC4655419)

Gourevich, D., Volovick, A., Dogadkin, O., Wang, L., Mulvana, H., Medan, Y., Melzer, A. and Cochran, S. (2015) In vitro investigation of the individual contributions of ultrasound-induced stable and inertial cavitation in targeted drug delivery. Ultrasound in Medicine and Biology, 41(7), pp. 1853-1864. (doi:10.1016/j.ultrasmedbio.2015.03.016) (PMID:25887690)

Mulvana, H., Cochran, S. and Hill, M. (2013) Ultrasound assisted particle and cell manipulation on-chip. Advanced Drug Delivery Reviews, 65(11-12), pp. 1600-1610. (doi:10.1016/j.addr.2013.07.016)

Casey, J., Sennoga, C., Mulvana, H., Hajnal, J.V., Tang, M.-X. and Eckersley, R.J. (2013) Single bubble acoustic characterization and stability measurement of adherent microbubbles. Ultrasound in Medicine and Biology, 39(5), pp. 903-914. (doi:10.1016/j.ultrasmedbio.2012.12.007)

Mulvana, H., Browning, R.J., Tang, M.-X., Hajnal, J.V. and Eckersley, R.J. (2012) Albumin coated microbubble optimization: custom fabrication and comprehensive characterization. Ultrasound in Medicine and Biology, 38(9), pp. 1599-1607. (doi:10.1016/j.ultrasmedbio.2012.05.002)

Browning, R.J., Mulvana, H., Tang, M.-X., Hajnal, J.V., Wells, D.J. and Eckersley, R.J. (2012) Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo. Ultrasound in Medicine and Biology, 38(6), pp. 1067-1077. (doi:10.1016/j.ultrasmedbio.2012.02.020)

Mulvana, H., Stride, E., Tang, M.-X., Hajnal, J.V. and Eckersley, R.J. (2012) The influence of gas saturation on microbubble stability. Ultrasound in Medicine and Biology, 38(6), pp. 1097-1100. (doi:10.1016/j.ultrasmedbio.2012.02.008)

Mulvana, H., Eckersley, R.J., Tang, M.-X., Pankhurst, Q. and Stride, E. (2012) Theoretical and experimental characterisation of magnetic microbubbles. Ultrasound in Medicine and Biology, 38(5), pp. 864-875. (doi:10.1016/j.ultrasmedbio.2012.01.027)

Browning, R.J., Mulvana, H., Tang, M., Hajnal, J.V., Wells, D.J. and Eckersley, R.J. (2011) Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection. Ultrasound in Medicine and Biology, 37(9), pp. 1531-1537. (doi:10.1016/j.ultrasmedbio.2011.05.019)

Mulvana, H., Stride, E., Tang, M., Hajnal, J.V. and Eckersley, R. (2011) Temperature-dependent differences in the nonlinear acoustic behavior of ultrasound contrast agents revealed by high-speed imaging and bulk acoustics. Ultrasound in Medicine and Biology, 37(9), pp. 1509-1517. (doi:10.1016/j.ultrasmedbio.2011.05.020)

Tang, M.-X., Mulvana, H., Gauthier, T., Lim, A.K.P., Cosgrove, D.O., Eckersley, R.J. and Stride, E. (2011) Quantitative contrast-enhanced ultrasound imaging: a review of sources of variability. Interface Focus, 1(4), pp. 520-539. (doi:10.1098/rsfs.2011.0026)

Mulvana, H., Stride, E., Hajnal, J.V. and Eckersley, R.J. (2010) Temperature dependent behavior of ultrasound contrast agents. Ultrasound in Medicine and Biology, 36(6), pp. 925-934. (doi:10.1016/j.ultrasmedbio.2010.03.003)

Book Sections

Stride, E., Mulvana, H., Eckersley, R.J., Tang, M.-X. and Pankhurst, Q. (2011) Magnetic microbubbles. In: Thanh, N.T.K. (ed.) Magnetic Nanoparticles: From Fabriation to Clinical Applications. CRC Press: Boca Raton, FL. ISBN 9781439869321

Conference Proceedings

Mulvana, H., Eckersley, R.J., Browning, R., Hajnal, J.V., Stride, E., Barrack, T., Tang, M., Pankhurst, Q. and Wells, D. (2010) Enhanced Gene Transfection in vivo using Magnetic Localisation of Ultrasound Contrast Agents: Preliminary Results. In: IEEE International Ultrasonics Symposium 2010, San Diego, 11-14 Oct 2010, pp. 670-673. (doi:10.1109/ULTSYM.2010.5935952)

Mulvana, H., Eckersley, R.J. and Stride, E. (2009) Temperature behaviour of ultrasound contrast agents. In: IEEE International Ultrasonics Symposium, Rome, Italy, 20-23 Sept 2009, pp. 1239-1242. (doi:10.1109/ULTSYM.2009.5441522)

Wallace, M.F., Mulvana, H., Marin, P., Mayne, K., Walsh, M.P., Wright, R., Marsh, R., Spence, B., Solomonidis, S. and Cochran, S. (2007) 4F-4 parametric array design and characterisation for underwater sonar and medical strain imaging applications. In: IEEE International Ultrasonics Symposium, New York, USA, 28-31 Oct 2007, pp. 305-308. (doi:10.1109/ULTSYM.2007.87)

Mulvana, H., Parker, M.F., Cochran, S., Spence, B. and Solomonidis, S. (2006) P3E-8 technique for automatic characterisation of an amputee's residual limb. In: IEEE International Ultrasonics Symposium 2006, Vancouver, Canada, 3-6 Oct 2006, pp. 2088-2091. (doi:10.1109/ULTSYM.2006.500)

This list was generated on Tue Sep 19 11:03:40 2017 BST.