Dr Helen Mulvana

  • Lord Kelvin Adam Smith Research Fellow (Systems Power and Energy)

telephone: 01413305044
email: Helen.Mulvana@glasgow.ac.uk

Research interests

Biography

Helen was awarded a BEng (Hons) in Mechanical Engineering (Product Design) from the University of Glasgow in 2001. On graduating she joined Renishaw plc as a Design and Development Engineer before returning to academia in 2003 to study for an EngD in Medical Devices (EPSRC) in the Department of Bioengineering, University of Strathclyde. In 2008, following a year as a Project Leader at TWI Ltd, Helen joined the Faculty of Medicine at Imperial College London as a Post-Doctoral Research Associate. In 2012 she returned to the University of Glasgow where she is currently a Lord Kelvin Adam Smith Fellow based in the School of Engineering.

Research Interests

Helen’s research interests are in the use of ultrasound for therapy, and more specifically the generation of techniques and tools for safe, non-invasive Targeted Drug Delivery (TDD) to treat cancer.
Ultrasound is capable of generating bio-effects in tissues which can be used to develop transient vascular and cellular porosity for localised drug delivery. The technique offers huge potential to treat a wide range of diseases and the principle has been widely demonstrated pre-clinically. Particular success has been achieved with the use of systemically delivered gas microbubbles, which can act to enhance the generation of bio-effects at low ultrasonic (diagnostic) intensities. However, the processes which facilitate ultrasound mediated TDD are not fully understood and this has limited delivery efficiencies and progress towards clinical application.

Helen’s research focuses on developing a better understanding of how ultrasound can be used to generate cellular porosity and the development of improved protocols and devices for improving drug/gene delivery.

Selected publications

Supervision

I welcome enquiries from students interested in working with me in the areas of ultrasound mediated targeted drug delivery, medical ultrasound or ultrasound contrast agents.


In addition, I am currently advertising the following PhD projects:
1. A physiologically relevant model for Ultrasound activated Targeted Drug Delivery (TDD).
2. High throughput investigation of ultrasound and microbubble activated drug delivery.
3. The manipulation and activation of microbubble ultrasound contrast agent through Optoelectronic Tweezers (OET) and Surface Acoustic Waves (SAW).


Feel free to contact me for an informal discussion and in addition you can find more information on the School of Engineering website or from the advert on findaphd.com.

Teaching

Introduction to Biomedical Engineering 1

Cellular Biophysics 4

Advanced Imaging and Therapy 5

All publications

List by: Type | Date

Jump to: 2017 | 2015 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007 | 2006
Number of items: 18.

2017

Mulvana, H., Browning, R. J., Luan, Y., de Jong, N., Tang, M.-X., Eckersley, R. J., and Stride, E. (2017) Characterisation of contrast agent microbubbles for ultrasound imaging and therapy research. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 64(1), pp. 232-251. (doi:10.1109/TUFFC.2016.2613991) (PMID:27810805)

2015

Foster, J. S. et al. (2015) Gelation landscape engineering using a multi-reaction supramolecular hydrogelator system. Journal of the American Chemical Society, 137(45), pp. 14236-14239. (doi:10.1021/jacs.5b06988) (PMID:26502267) (PMCID:PMC4655419)

Gourevich, D., Volovick, A., Dogadkin, O., Wang, L., Mulvana, H., Medan, Y., Melzer, A., and Cochran, S. (2015) In vitro investigation of the individual contributions of ultrasound-induced stable and inertial cavitation in targeted drug delivery. Ultrasound in Medicine and Biology, 41(7), pp. 1853-1864. (doi:10.1016/j.ultrasmedbio.2015.03.016) (PMID:25887690)

2013

Mulvana, H., Cochran, S., and Hill, M. (2013) Ultrasound assisted particle and cell manipulation on-chip. Advanced Drug Delivery Reviews, 65(11-12), pp. 1600-1610. (doi:10.1016/j.addr.2013.07.016)

Casey, J., Sennoga, C., Mulvana, H., Hajnal, J.V., Tang, M.-X., and Eckersley, R.J. (2013) Single bubble acoustic characterization and stability measurement of adherent microbubbles. Ultrasound in Medicine and Biology, 39(5), pp. 903-914. (doi:10.1016/j.ultrasmedbio.2012.12.007)

2012

Mulvana, H., Browning, R.J., Tang, M.-X., Hajnal, J.V., and Eckersley, R.J. (2012) Albumin coated microbubble optimization: custom fabrication and comprehensive characterization. Ultrasound in Medicine and Biology, 38(9), pp. 1599-1607. (doi:10.1016/j.ultrasmedbio.2012.05.002)

Browning, R.J., Mulvana, H., Tang, M.-X., Hajnal, J.V., Wells, D.J., and Eckersley, R.J. (2012) Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo. Ultrasound in Medicine and Biology, 38(6), pp. 1067-1077. (doi:10.1016/j.ultrasmedbio.2012.02.020)

Mulvana, H., Stride, E., Tang, M.-X., Hajnal, J.V., and Eckersley, R.J. (2012) The influence of gas saturation on microbubble stability. Ultrasound in Medicine and Biology, 38(6), pp. 1097-1100. (doi:10.1016/j.ultrasmedbio.2012.02.008)

Mulvana, H., Eckersley, R.J., Tang, M.-X., Pankhurst, Q., and Stride, E. (2012) Theoretical and experimental characterisation of magnetic microbubbles. Ultrasound in Medicine and Biology, 38(5), pp. 864-875. (doi:10.1016/j.ultrasmedbio.2012.01.027)

2011

Browning, R.J., Mulvana, H., Tang, M., Hajnal, J.V., Wells, D.J., and Eckersley, R.J. (2011) Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection. Ultrasound in Medicine and Biology, 37(9), pp. 1531-1537. (doi:10.1016/j.ultrasmedbio.2011.05.019)

Mulvana, H., Stride, E., Tang, M., Hajnal, J.V., and Eckersley, R. (2011) Temperature-dependent differences in the nonlinear acoustic behavior of ultrasound contrast agents revealed by high-speed imaging and bulk acoustics. Ultrasound in Medicine and Biology, 37(9), pp. 1509-1517. (doi:10.1016/j.ultrasmedbio.2011.05.020)

Tang, M.-X., Mulvana, H., Gauthier, T., Lim, A.K.P., Cosgrove, D.O., Eckersley, R.J., and Stride, E. (2011) Quantitative contrast-enhanced ultrasound imaging: a review of sources of variability. Interface Focus, 1(4), pp. 520-539. (doi:10.1098/rsfs.2011.0026)

Stride, E., Mulvana, H., Eckersley, R.J., Tang, M.-X., and Pankhurst, Q. (2011) Magnetic microbubbles. In: Thanh, N.T.K. (ed.) Magnetic Nanoparticles: From Fabriation to Clinical Applications. CRC Press: Boca Raton, FL. ISBN 9781439869321

2010

Mulvana, H., Stride, E., Hajnal, J.V., and Eckersley, R.J. (2010) Temperature dependent behavior of ultrasound contrast agents. Ultrasound in Medicine and Biology, 36(6), pp. 925-934. (doi:10.1016/j.ultrasmedbio.2010.03.003)

Mulvana, H., Eckersley, R.J., Browning, R., Hajnal, J.V., Stride, E., Barrack, T., Tang, M., Pankhurst, Q., and Wells, D. (2010) Enhanced Gene Transfection in vivo using Magnetic Localisation of Ultrasound Contrast Agents: Preliminary Results. In: IEEE International Ultrasonics Symposium 2010, San Diego, 11-14 Oct 2010, pp. 670-673. (doi:10.1109/ULTSYM.2010.5935952)

2009

Mulvana, H., Eckersley, R.J., and Stride, E. (2009) Temperature behaviour of ultrasound contrast agents. In: IEEE International Ultrasonics Symposium, Rome, Italy, 20-23 Sept 2009, pp. 1239-1242. (doi:10.1109/ULTSYM.2009.5441522)

2007

Wallace, M.F., Mulvana, H., Marin, P., Mayne, K., Walsh, M.P., Wright, R., Marsh, R., Spence, B., Solomonidis, S., and Cochran, S. (2007) 4F-4 parametric array design and characterisation for underwater sonar and medical strain imaging applications. In: IEEE International Ultrasonics Symposium, New York, USA, 28-31 Oct 2007, pp. 305-308. (doi:10.1109/ULTSYM.2007.87)

2006

Mulvana, H., Parker, M.F., Cochran, S., Spence, B., and Solomonidis, S. (2006) P3E-8 technique for automatic characterisation of an amputee's residual limb. In: IEEE International Ultrasonics Symposium 2006, Vancouver, Canada, 3-6 Oct 2006, pp. 2088-2091. (doi:10.1109/ULTSYM.2006.500)

This list was generated on Tue Mar 28 20:44:11 2017 BST.
Number of items: 18.

Articles

Mulvana, H., Browning, R. J., Luan, Y., de Jong, N., Tang, M.-X., Eckersley, R. J., and Stride, E. (2017) Characterisation of contrast agent microbubbles for ultrasound imaging and therapy research. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 64(1), pp. 232-251. (doi:10.1109/TUFFC.2016.2613991) (PMID:27810805)

Foster, J. S. et al. (2015) Gelation landscape engineering using a multi-reaction supramolecular hydrogelator system. Journal of the American Chemical Society, 137(45), pp. 14236-14239. (doi:10.1021/jacs.5b06988) (PMID:26502267) (PMCID:PMC4655419)

Gourevich, D., Volovick, A., Dogadkin, O., Wang, L., Mulvana, H., Medan, Y., Melzer, A., and Cochran, S. (2015) In vitro investigation of the individual contributions of ultrasound-induced stable and inertial cavitation in targeted drug delivery. Ultrasound in Medicine and Biology, 41(7), pp. 1853-1864. (doi:10.1016/j.ultrasmedbio.2015.03.016) (PMID:25887690)

Mulvana, H., Cochran, S., and Hill, M. (2013) Ultrasound assisted particle and cell manipulation on-chip. Advanced Drug Delivery Reviews, 65(11-12), pp. 1600-1610. (doi:10.1016/j.addr.2013.07.016)

Casey, J., Sennoga, C., Mulvana, H., Hajnal, J.V., Tang, M.-X., and Eckersley, R.J. (2013) Single bubble acoustic characterization and stability measurement of adherent microbubbles. Ultrasound in Medicine and Biology, 39(5), pp. 903-914. (doi:10.1016/j.ultrasmedbio.2012.12.007)

Mulvana, H., Browning, R.J., Tang, M.-X., Hajnal, J.V., and Eckersley, R.J. (2012) Albumin coated microbubble optimization: custom fabrication and comprehensive characterization. Ultrasound in Medicine and Biology, 38(9), pp. 1599-1607. (doi:10.1016/j.ultrasmedbio.2012.05.002)

Browning, R.J., Mulvana, H., Tang, M.-X., Hajnal, J.V., Wells, D.J., and Eckersley, R.J. (2012) Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo. Ultrasound in Medicine and Biology, 38(6), pp. 1067-1077. (doi:10.1016/j.ultrasmedbio.2012.02.020)

Mulvana, H., Stride, E., Tang, M.-X., Hajnal, J.V., and Eckersley, R.J. (2012) The influence of gas saturation on microbubble stability. Ultrasound in Medicine and Biology, 38(6), pp. 1097-1100. (doi:10.1016/j.ultrasmedbio.2012.02.008)

Mulvana, H., Eckersley, R.J., Tang, M.-X., Pankhurst, Q., and Stride, E. (2012) Theoretical and experimental characterisation of magnetic microbubbles. Ultrasound in Medicine and Biology, 38(5), pp. 864-875. (doi:10.1016/j.ultrasmedbio.2012.01.027)

Browning, R.J., Mulvana, H., Tang, M., Hajnal, J.V., Wells, D.J., and Eckersley, R.J. (2011) Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection. Ultrasound in Medicine and Biology, 37(9), pp. 1531-1537. (doi:10.1016/j.ultrasmedbio.2011.05.019)

Mulvana, H., Stride, E., Tang, M., Hajnal, J.V., and Eckersley, R. (2011) Temperature-dependent differences in the nonlinear acoustic behavior of ultrasound contrast agents revealed by high-speed imaging and bulk acoustics. Ultrasound in Medicine and Biology, 37(9), pp. 1509-1517. (doi:10.1016/j.ultrasmedbio.2011.05.020)

Tang, M.-X., Mulvana, H., Gauthier, T., Lim, A.K.P., Cosgrove, D.O., Eckersley, R.J., and Stride, E. (2011) Quantitative contrast-enhanced ultrasound imaging: a review of sources of variability. Interface Focus, 1(4), pp. 520-539. (doi:10.1098/rsfs.2011.0026)

Mulvana, H., Stride, E., Hajnal, J.V., and Eckersley, R.J. (2010) Temperature dependent behavior of ultrasound contrast agents. Ultrasound in Medicine and Biology, 36(6), pp. 925-934. (doi:10.1016/j.ultrasmedbio.2010.03.003)

Book Sections

Stride, E., Mulvana, H., Eckersley, R.J., Tang, M.-X., and Pankhurst, Q. (2011) Magnetic microbubbles. In: Thanh, N.T.K. (ed.) Magnetic Nanoparticles: From Fabriation to Clinical Applications. CRC Press: Boca Raton, FL. ISBN 9781439869321

Conference Proceedings

Mulvana, H., Eckersley, R.J., Browning, R., Hajnal, J.V., Stride, E., Barrack, T., Tang, M., Pankhurst, Q., and Wells, D. (2010) Enhanced Gene Transfection in vivo using Magnetic Localisation of Ultrasound Contrast Agents: Preliminary Results. In: IEEE International Ultrasonics Symposium 2010, San Diego, 11-14 Oct 2010, pp. 670-673. (doi:10.1109/ULTSYM.2010.5935952)

Mulvana, H., Eckersley, R.J., and Stride, E. (2009) Temperature behaviour of ultrasound contrast agents. In: IEEE International Ultrasonics Symposium, Rome, Italy, 20-23 Sept 2009, pp. 1239-1242. (doi:10.1109/ULTSYM.2009.5441522)

Wallace, M.F., Mulvana, H., Marin, P., Mayne, K., Walsh, M.P., Wright, R., Marsh, R., Spence, B., Solomonidis, S., and Cochran, S. (2007) 4F-4 parametric array design and characterisation for underwater sonar and medical strain imaging applications. In: IEEE International Ultrasonics Symposium, New York, USA, 28-31 Oct 2007, pp. 305-308. (doi:10.1109/ULTSYM.2007.87)

Mulvana, H., Parker, M.F., Cochran, S., Spence, B., and Solomonidis, S. (2006) P3E-8 technique for automatic characterisation of an amputee's residual limb. In: IEEE International Ultrasonics Symposium 2006, Vancouver, Canada, 3-6 Oct 2006, pp. 2088-2091. (doi:10.1109/ULTSYM.2006.500)

This list was generated on Tue Mar 28 20:44:11 2017 BST.