- Chair of Chemical Biology and Medicinal Chemistry (School of Chemistry)
Research in the Liskamp group will be directed towards the creation of molecules which can be used for obtaining insights in diseases like infections and cancer, which may also lead to new approaches for their treatment.
Inspired by biological systems and architectures, protein mimics will be constructed for synthetic vaccine (HIV, Influenza) or synthetic antibody applications.
Chemical biology and synthetic biology approaches will be used to support or enable important developments in biological areas such as stem cell research, tissue engineering and regenerative medicine. Central in our activities is the design and synthesis of molecular constructs of the future by chemo and/or biosynthetic approaches, optimization by design, combinatorial or evolutionary approaches and their use to study and modulate important biological processes.
Brouwer, A.J. et al.
Peptido sulfonyl fluorides as new powerful proteasome inhibitors.
Journal of Medicinal Chemistry, 55(24),
Vosyka, O., Vinothkumar, K.R., Wolf, E.V., Brouwer, A.J., Liskamp, R.M.J., and Verhelst, S.H.L.
Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay.
Proceedings of the National Academy of Sciences of the United States of America, 110(7),
Crielaard, B.J. et al.
Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis.
Angewandte Chemie (International Edition), 51(29),
Mulder, G.E., Kruijtzer, J.A.W., and Liskamp, R.M.J.
A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold.
Chemical Communications, 48(80),
- Biopolymer Chemistry and Synthesis (Final year)
- Ÿ Part-time (0.2 fte) Professor of Molecular Medicinal Chemistry at the University of Utrecht (The Netherlands)