Dr Andrew Sutherland

  • Reader (Chemistry)

telephone: 01413305936
email: Andrew.Sutherland@glasgow.ac.uk

Research interests

‌Research Interests

Research in the Sutherland group is focused on a number of key areas. Our main programme of research centres on molecular imaging of disease. We have a number of projects that develop novel PET and SPECT tracers for the radionuclide imaging of a range of neurological diseases as well as cancer. We are also investigating amino acid based fluorescent probes for cell imaging. Supporting these projects is a synthetic chemistry programme, which seeks to develop new transition metal catalysed transformations and one-pot multi-reaction processes for the rapid preparation of polycyclic drug-like scaffolds and natural products.

‌Research Topics

PET and SPECT Imaging Agents

Fluorescent Amino Acids

Transition metal catalysed reactions

One-pot multi-reaction processes

obc2010 obc2011

Publication Highlights

  • D. T. Racys, S. A. I. Sharif, S. L. Pimlott and A. Sutherland, Silver(I)-Catalyzed Iodination of Arenes: Tuning the Lewis Acidity of N-Iodosuccinimide Activation, J. Org. Chem., 2016, 81, 772-780.
  • D. T. Racys, C. E. Warrilow, S. L. Pimlott and A. Sutherland, Highly Regioselective Iodination of Arenes via Iron(III)-Catalyzed Activation of N-Iodosuccinimide, Org. Lett., 2015, 17, 4782-4785. 
  • A. Blair, F. Zmuda, G. Malviya, A. A. S. Tavares, G. D. Tamagnan, A. J. Chalmers, D. Dewar, S. L. Pimlott and A. Sutherland, A Novel 18F-Labelled High Affinity Agent for PET Imaging of the Translocator Protein, Chem. Sci., 2015, 6, 4772-4777.
  • E. D. D. Calder and A. Sutherland, Enantioselective Synthesis of 3-Methyleneindan-1-ols via a One-Pot Allylboration-Heck Reaction of 2-Bromobenzaldehydes, Org. Lett., 2015, 17, 2514-2517.
  • A. A. Cant, S. Champion, R. Bhalla, S. L. Pimlott and A. Sutherland, Nickel-Mediated Radioiodination of Aryl and Heteroaryl Bromides: Rapid Synthesis of Tracers for SPECT Imaging, Angew. Chem. Int. Ed., 2013, 52, 7829-7832.

Selected publications

Teaching

Teaching

  • Level-2 Isomerism and Stereochemistry
  • Level-3 Organic Synthesis 1
  • Level-3 Biotransformations 1 and 2
  • Level-4 Pericyclic Reactions

Additional information

Awards

BSc (Edinburgh) PhD (Bristol) MRSC CChem

Selected Recent Talks

  • "New Stereoselective Synthesis of N-Heterocycles". Departmental Seminar, ICSN, CNRS, Gif-sur-Yvette, March 2011. 
  • "New Stereoselective Rearrangement Processes for the Synthesis of Natural Products". Departmental Seminar, Universite Pierre et Marie Curie, March 2011. 
  • "Stereoselective Rearrangements for the Preparation of Natural Products". Wilson Baker Symposium, University of Bristol, March, 2011. 
  • "New Stereoselective Rearrangement Processes for the Synthesis of Natural Products". Research Seminar, Almac Discovery, Northern Ireland, January 2011. 
  • "The Stereoselective Synthesis of Iodinated Analogues of Reboxetine for SPECT Imaging the Noradrenaline Transporter". 42nd IUPAC Congress, Glasgow, August 2009.

External Appointments & Positions

  • External Examiner in Chemistry for GlaxoSmithKline/University of Kent
  • EPSRC College and Panel Member
  • Member of the Board of Tetrahedron Letters
  • Member of the SINAPSE Molecular Imaging Committee
  • Member of the Tetrahedron Referee Panel

All publications

List by: Type | Date

Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004
Number of items: 109.

2015

Calder, E. D.D., and Sutherland, A. (2015) Enantioselective synthesis of 3-methylene-indan-1-ols via a one-pot allylboration-heck reaction of 2-bromobenzaldehydes. Organic Letters, 17(10), pp. 2514-2517. (doi:10.1021/acs.orglett.5b01047)

Calder, E. D.D., and Sutherland, A. (2015) Enantioselective synthesis of 3-methyleneindan-1-ols via a one-pot allylboration–Heck reaction of 2-bromobenzaldehydes. Organic Letters, 17(10), pp. 2514-2517. (doi:10.1021/acs.orglett.5b01047) (PMID:25933177)

Calder, E. D.D., Sharif, S. A.I., McGonagle, F. I., and Sutherland, A. (2015) One-pot synthesis of 5-amino-2,5-dihydro-1-benzoxepines: access to pharmacologically active heterocyclic scaffolds. Journal of Organic Chemistry, 80(9), pp. 4683-4696. (doi:10.1021/acs.joc.5b00583) (PMID:25847814)

Gilfillan, L., Artschwager, R., Harkiss, A. H., Liskamp, R. M.J., and Sutherland, A. (2015) Synthesis of pyrazole containing α-amino acids via a highly regioselective condensation/aza-Michael reaction of β-aryl α,β-unsaturated ketones. Organic and Biomolecular Chemistry, 13(15), pp. 4514-4523. (doi:10.1039/C5OB00364D) (PMID:25774874)

Reid, C. M., Fanning, K. N., Fowler, L. S., and Sutherland, A. (2015) Synthesis and reactivity of 4-oxo-5-trimethylsilanyl derived α-amino acids. Tetrahedron, 71(2), pp. 245-251. (doi:10.1016/j.tet.2014.11.059)

Blair, A., Zmuda, F., Malviya, G., Chalmers, A. J., Dewar, D., Pimlott, S. L., and Sutherland, A. (2015) A novel 18F-labelled high affinity agent for PET imaging of the translocator protein. Chemical Science, (doi:10.1039/C5SC01647A) (Early Online Publication)

2014

Hill, R. A., and Sutherland, A. (2014) Hot off the press. Natural Product Reports, 31(12), pp. 1671-1675. (doi:10.1039/C4NP90041C)

Grafton, M., Johnson, S. A., Farrugia, L. J., and Sutherland, A. (2014) Diastereoselective synthesis of highly substituted polycyclic scaffolds via a one-pot four-step tandem catalytic process. Tetrahedron Letters, 70(40), pp. 7133-7141. (doi:10.1016/j.tet.2014.06.020)

Hill, R. A., and Sutherland, A. (2014) Hot off the press. Natural Product Reports, 31(10), pp. 1242-1246. (doi:10.1039/C4NP90032D)

Hill, R. A., and Sutherland, A. (2014) Hot off the press. Natural Product Reports, 31(9), pp. 1083-1087. (doi:10.1039/C4NP90023E)

Calder, E. D.D., McGonagle, F. I., Harkiss, A. H., McGonagle, G. A., and Sutherland, A. (2014) Preparation of amino-substituted indenes and 1,4-dihydronaphthalenes using a one-pot multireaction approach: total synthesis of oxybenzo[c]phenanthridine alkaloids. Journal of Organic Chemistry, 79(16), pp. 7633-7648. (doi:10.1021/jo5014492)

Hill, R. A., and Sutherland, A. (2014) Hot off the press. Natural Product Reports, 31(6), pp. 706-710. (doi:10.1039/C4NP90015D)

Calder, E. D.D., Grafton, M. W., and Sutherland, A. (2014) One-pot multi-reaction processes: synthesis of natural products and drug-like scaffolds. Synlett, 25(8), pp. 1068-1080. (doi:10.1055/s-0033-1340683)

Hill, R. A., and Sutherland, A. (2014) Hot off the press. Natural Product Reports, 31(4), pp. 414-418. (doi:10.1039/C4NP90007C)

Hill, R. A., and Sutherland, A. (2014) Hot off the press. Natural Product Reports, 31(4), pp. 414-418. (doi:10.1039/C3NP90044D)

Zaed, A. M., Grafton, M. W., Ahmad, S., and Sutherland, A. (2014) Asymmetric synthesis of cis-aminocyclopentenols, building blocks for medicinal chemistry. Journal of Organic Chemistry, 79(3), pp. 1511-1515. (doi:10.1021/jo402712r)

2013

Hill, R. A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30(12), pp. 1462-1466. (doi:10.1039/C3NP90036C)

Hill, R. A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30(12), pp. 1462-1466. (doi:10.1039/C3NP90029K)

Hill, R. A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30(12), pp. 1074-1078. (doi:10.1039/C3NP90022C)

Cant, A.A., Champion, S., Bhalla, R., Pimlott, S.L., and Sutherland, A. (2013) Nickel-mediated radioiodination of aryl and heteroaryl bromides: rapid synthesis of tracers for SPECT imaging. Angewandte Chemie (International Edition), 52(30), pp. 7829-7832. (doi:10.1002/anie.201302800)

Calder, E.D.D., Zaed, A.M., and Sutherland, A. (2013) Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-Sphinganine, (+)-spisulosine and D-ribo-phytosphingosine. Journal of Organic Chemistry, 78(14), pp. 7223-7233. (doi:10.1021/jo401211j)

Grafton, M. W., Farrugia, L. J., and Sutherland, A. (2013) Synthesis of amino substituted indanes and tetralins via consecutive multi-bond forming tandem processes. Journal of Organic Chemistry, 78(14), pp. 7199-7207. (doi:10.1021/jo401182r)

Gilfillan, L., Blair, A., Morris, B., Pratt, J., Schweiger, L., Pimlott, S., and Sutherland, A. (2013) Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor. MedChemComm, 4(7), pp. 1118-1123. (doi:10.1039/c3md00110e)

Hill, R. A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30(12), pp. 760-764. (doi:10.1039/C3NP90015K)

Hill, R. A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30(12), pp. 485-489. (doi:10.1039/C3NP90007J)

Blair, A., Stevenson, L., Dewar, D., Pimlott, S.L., and Sutherland, A. (2013) Structure–activity relationships of novel iodinated quinoline-2-carboxamides for targeting the translocator protein. MedChemComm, 4(11), pp. 1461-1466. (doi:10.1039/c3md00249g)

Hill, R.A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30(2), pp. 213-217. (doi:10.1039/C2NP90051C)

2012

Blair, A., Stevenson, L., and Sutherland, A. (2012) Synthesis of the isoquinoline alkaloid, crispine C. Tetrahedron Letters, 53(32), pp. 4084-4086. (doi:10.1016/j.tetlet.2012.05.113)

Ahmad, S., Swift, M., Farrugia, L., Senn, H.M., and Sutherland, A. (2012) Stereoselective synthesis of functionalised carbocyclic amides: construction of the syn-(4aS,10bS)-phenanthridone skeleton. Organic and Biomolecular Chemistry, 10(19), pp. 3937-3945. (doi:10.1039/C2OB25334H)

Hill, R., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29(2), p. 129. (doi:10.1039/C1NP90052H)

Ahmad, S., and Sutherland, A. (2012) Stereoselective synthesis of hydroxylated 3-aminoazepanes using a multi-bond forming, three-step tandem process. Organic and Biomolecular Chemistry, 10(41), pp. 8251-8259. (doi:10.1039/C2OB26544C)

Cant, A., Bhalla, R., Pimlott, S.L., and Sutherland, A. (2012) Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides. Chemical Communications, 48(33), pp. 3993-3995. (doi:10.1039/c2cc30956d )

Daly, M., Cant, A.A., Fowler, L.S., Simpson, G.L., Senn, H.M., and Sutherland, A. (2012) Switching the stereochemical outcome of 6-endo-trig cyclizations; Synthesis of 2,6-Cis-6-substituted 4-oxopipecolic acids. Journal of Organic Chemistry, 77(22), pp. 10001-10009. (doi:10.1021/jo3022583)

Grafton, M.W., Farrugia, L.J., Senn, H.M., and Sutherland, A. (2012) Discovery of a multi-bond forming, four-step tandem process: construction of drug-like polycyclic scaffolds. Chemical Communications, 48, pp. 7994-7996. (doi:10.1039/c2cc33649a)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29(4), pp. 435-439. (doi:10.1039/C2NP90008D)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29(6), pp. 617-621. (doi:10.1039/C2NP90016E )

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29(8), p. 829. (doi:10.1039/C2NP90024F)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29(10), pp. 1033-1037. (doi:10.1039/C2NP90033E)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29(12), pp. 1377-1381. (doi:10.1039/C2NP90041F)

Sutherland, A., and Cant, A. (2012) Asymmetric synthesis of pipecolic acid and derivatives. Synthesis, 44(13), pp. 1935-1950. (doi:10.1055/s-0031-1289767)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., Pimlott, S.L., Batis, J., Barret, O., Seibyl, J., and Tamagnan, G. (2012) Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography. Synapse, 66(11), pp. 923-930. (doi:10.1002/syn.21585)

2011

Hill, R., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28(12), p. 1879. (doi:10.1039/C1NP90043A)

Zaed, A., and Sutherland, A. (2011) Total synthesis of clavaminol A, C and H. Organic and Biomolecular Chemistry, 9(23), pp. 8030-8037. (doi:10.1039/C1OB06060K)

Daly, M., Gill, K., Sime, M., Simpson, G.L., and Sutherland, A. (2011) A new general approach for the stereocontrolled synthesis of functionalised γ- and δ-lactams. Organic and Biomolecular Chemistry, 9(19), p. 6761. (doi:10.1039/C1OB05833A)

Fowler, L.S., Thomas, L.H., Ellis, D., and Sutherland, A. (2011) A one-pot reductive amination/6-endo-trig cyclisation for the stereoselective synthesis of 6-substituted-4-oxopipecolic acids. Chemical Communications, 47(23), pp. 6569-6571. (doi:10.1039/c1cc11916h )

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., and Pimlott, S.L. (2011) Development of the radiosynthesis of high-specific-activity 123I-NKJ64. Nuclear Medicine and Biology, 38(4), pp. 493-500. (doi:10.1016/j.nucmedbio.2010.11.011)

Fowler, L.S., Sutherland, A., Procter, J., and Molander, G.A. (2011) Product class 6: acyclic and semicyclic o/o acetals. In: Ishihara, K., Krause, N. and Procter, D. (eds.) Science of Synthesis Knowledge Updates. Thieme, p. 121. ISBN 9783131541611

Ahmad, S. , Thomas, L.H. , and Sutherland, A. (2011) Stereoselective synthesis of polyhydroxylated aminocyclohexanes. Organic and Biomolecular Chemistry, 9, pp. 2801-2808. (doi:10.1039/C0OB00619J )

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28(6), pp. 1031-1034. (doi:10.1039/C1NP90013G)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28(8), pp. 1345-1349. (doi:10.1039/C1NP90027G)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28(4), pp. 659-662. (doi:10.1039/C1NP90009A)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28(2), pp. 182-185. (doi:10.1039/C0NP90038A)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28(10), pp. 1621-1625. (doi:10.1039/C1NP90035H)

McGonagle, F.I., Brown, L., Cooke, A., and Sutherland, A. (2011) Microwave-promoted tandem reactions for the synthesis of bicyclic γ-lactams. Tetrahedron Letters, 52(18), pp. 2330-2332. (doi:10.1016/j.tetlet.2011.02.089)

Pimlott, S.L., and Sutherland, A. (2011) Molecular tracers for the PET and SPECT imaging of disease. Chemical Society Reviews, 40(1), pp. 149-162. (doi:10.1039/B922628C)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., and Pimlott, S.L. (2011) 123I-NKJ64: A novel single photon emission computed tomography radiotracer for imaging the noradrenaline transporter in brain. Synapse, 65(7), pp. 658-667. (doi:10.1002/syn.20895)

2010

Drummond, L.J., and Sutherland, A. (2010) Asymmetric synthesis of allylic secondary alcohols: a new general approach for the preparation of α-amino acids. Tetrahedron, 66(29), pp. 5349-5356. (doi:10.1016/j.tet.2010.05.066)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27(2), pp. 149-152. (doi:10.1039/B926722K)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27(4), pp. 477-480. (doi:10.1039/C003431M)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27(6), pp. 805-808. (doi:10.1039/C005230M)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27(8), pp. 1110-1113. (doi:10.1039/C005449F)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27(10), pp. 1381-1385. (doi:10.1039/C0NP90017F)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27(12), pp. 1733-1736. (doi:10.1039/C0NP90026E)

Kennedy, A.R., Kerr, W.J., Paterson, L.C., and Sutherland, A. (2010) A Tetrahydropentaleno[1,6a-a]naphthalen-4(2H)-one of Defined Relative Stereochemistry for Use Towards Agariblazeispirol C. Acta Crystallographica. Section D: Biological Crystallography, 66(9), 0473-0474. (doi:10.1107/S0108270110031781 )

McGonagle, F. I., Brown, L., Cooke, A., and Sutherland, A. (2010) A three-step tandem process for the synthesis of bicyclic gamma-lactams. Organic and Biomolecular Chemistry, 8(15), pp. 3418-3425. (doi:10.1039/c004695g )

Stevenson, L., Tavares, A.A.S., Brunet, A., McGonagle, F.I., Dewar, D., Pimlott, S.L., and Sutherland, A. (2010) New iodinated quinloine-2-varboxamides for SPECT imaging of the translocator protein. Bioorganic and Medicinal Chemistry Letters, 20(3), pp. 954-957. (doi:10.1016/j.bmcl.2009.12.061)

Tavares, A., Dewar, D., Sutherland, A., and Pimlott, S. (2010) (R,S)-2-Iodo-reboxetine: Development as a novel SPECT radiotracer for imaging the noradrenaline transporter in brain. Neuroimage, 52, S115-S115. (doi:10.1016/j.neuroimage.2010.04.094)

Zaed, A.M., and Sutherland, A. (2010) Stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin. Organic and Biomolecular Chemistry, 8(19), pp. 4394-4399. (doi:10.1039/C0OB00219D)

2009

Swift, M.D., Donaldson, A., and Sutherland, A. (2009) Tandem aza-Claisen rearrangement and ring closing metathesis reactions: the stereoselective synthesis of functionalised carbocyclic amides. Tetrahedron Letters, 50(26), pp. 3241-3244. (doi:10.1016/j.tetlet.2009.02.032)

Fowler, L.S., Ellis, D., and Sutherland, A. (2009) Synthesis of fluorescent enone derived α-amino acids. Organic and Biomolecular Chemistry, 7(20), pp. 4309-4316. (doi:10.1039/b912782h)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26(2), pp. 151-154. (doi:10.1039/B822940F)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26(4), pp. 461-464. (doi:10.1039/B903591P)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26(6), pp. 725-728. (doi:10.1039/B908225P)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26(8), pp. 973-976. (doi:10.1039/B912059A)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26(10), pp. 1229-1233. (doi:10.1039/B917244K)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26(12), pp. 1517-1520. (doi:10.1039/B921623P)

Jobson, N., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. (2009) Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 19(17), pp. 4996-4998. (doi:10.1016/j.bmcl.2009.07.064)

Reid., C.M., and Sutherland, A. (2009) Synthesis of isotopically labeled α-amino acids. In: Hughes, A.B. (ed.) Amino Acids, Peptides and Proteins in Organic Chemistry. Vol. 1. Origins and Synthesis of Amino Acids. Wiley-VCH: Weinham, Germany. ISBN 9783527320967

Zaed, A.M., Swift, M.D., and Sutherland, A. (2009) A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction. Organic and Biomolecular Chemistry, 7(13), pp. 2678-2680. (doi:10.1039/b907341h)

2008

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25(6), pp. 997-1000. (doi:10.1039/b818366j)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25(5), pp. 841-844. (doi:10.1039/B814878N)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25(4), pp. 647-650. (doi:10.1039/B810551K)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25(3), pp. 443-446. (doi:10.1039/B806751C)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25(2), pp. 216-219. (doi:10.1039/B803247P)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25(1), pp. 11-14. (doi:10.1039/B719710C)

Jobson, N., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. (2008) New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 18(18), pp. 4940-4943. (doi:10.1016/j.bmcl.2008.08.041)

Jobson, N., Spike, R., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. (2008) Stereoselective synthesis of (2S,3R)- and (2R,3S)-iodoreboxetine; potential SPECT imaging agents for the noradrenaline transporter. Organic and Biomolecular Chemistry, 6(13), pp. 2369-2376. (doi:10.1039/b802819b )

Pimlott, S. L., Stevenson, L., Wyper, D. J., and Sutherland, A. (2008) Rapid and efficient radiosynthesis of [I-123]I-PK11195, a single photon emission computed tomography tracer for peripheral benzodiazepine receptors. Nuclear Medicine and Biology, 35(5), pp. 537-542. (doi:10.1016/j.nucmedbio.2008.02.013)

Swift, M. D., and Sutherland, A. (2008) Studies on the aza-Claisen rearrangement of 4,5-dihydroxylated allylic trichloroacetimidates: the stereoselective synthesis of (2R,3S)- and (2S,3S)-2-amino-3,4-dihydroxybutyric acids. Tetrahedron, 64(40), pp. 9521-9527. (doi:10.1016/j.tet.2008.07.062)

2007

Bischoff, R., Hamilton, D., Jobson, N., and Sutherland, A. (2007) New approaches for the synthesis of isotopically labelled guanidine-derived amino acids and noradrenaline reuptake inhibitors. Journal of Labelled Compounds and Radiopharmaceuticals , 50, pp. 323-326. (doi:10.1002/jlcr.1242)

Fanning, K. N., and Sutherland, A. (2007) A facile synthesis of (S)-gizzerosine, a potent agonist of the histamine H-2-receptor. Tetrahedron Letters, 48(48), pp. 8479-8481. (doi:10.1016/j.tetlet.2007.09.165)

Jamieson, A., and Sutherland, A. (2007) Ether-directed palladium(II)-catalysed aza-Claisen rearrangements: studies on the origin of the directing effect. Tetrahedron, 63, pp. 2123-2131. (doi:10.1016/j.tet.2006.12.067)

Jamieson, A., and Sutherland, A. (2007) Ether-directed, stereoselective aza-Claisen rearrangements: Synthesis of the piperidine alkaloid, alpha-conhydrine. Organic Letters, 9, pp. 1609-1611. (doi:10.1021/ol070424z)

Pillai, B., Cherney, M., Diaper, C., Sutherland, A., Blanchard, J., Vederas, J., and James, M. (2007) Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase. Biochemical and Biophysical Research Communications, 363, pp. 547-553. (doi:10.1016/j.bbrc.2007.09.012)

Stevenson, L., Pimlott, S., and Sutherland, A. (2007) A novel approach for the synthesis of the peripheral benzodiazepine receptor ligand, PK11195. Tetrahedron Letters, 48, pp. 7137-7139. (doi:10.1016/j.tetlet.2007.07.203)

Swift, M. D., and Sutherland, A. (2007) A tandem aza-Claisen rearrangement and ring closing metathesis reaction for the synthesis of cyclic allylic trichloroacetamides. Organic Letters, 9(25), pp. 5239-5242. (doi:10.1021/ol702299c Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland.)

Swift, M., and Sutherland, A. (2007) A stereoselective synthesis of (2R,3S)-2-amino-3,4-dihydroxybutyric acid using an ether directed aza-Claisen rearrangement. Tetrahedron Letters, 48, pp. 3771-3773. (doi:10.1016/j.tetlet.2007.03.161)

Wilson, J., Giordani, F., Farrugia, L., Barrett, M., Robinsa, D., and Sutherland, A. (2007) Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles. Organic and Biomolecular Chemistry, 5, pp. 3651-3656. (doi:10.1039/b710487a)

Wilson, J., Henderson, G., Black, F., Sutherland, A., Ludwig, R., Vousden, K., and Robins, D. (2007) Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells. Bioorganic and Medicinal Chemistry Letters, 15, pp. 77-86. (doi:10.1016/j.bmc.2006.10.011)

2006

Fanning, K., Jamieson, A., and Sutherland, A. (2006) Palladium(II)-catalysed rearrangement reactions. Current Organic Chemistry, 10, pp. 1007-1020.

Jamieson, A., and Sutherland, A. (2006) Scope and limitations of ether-directed, metal-catalysed aza-Claisen rearrangements; improved stereoselectivity using non-coordinating solvents. Organic and Biomolecular Chemistry, 4, pp. 2932-2937. (doi:10.1039/b607014k)

Pillai, B., Cherney, M., Diaper, C., Sutherland, A., Blanchard, J., Vederas, J., and James, M. (2006) Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proceedings of the National Academy of Sciences of the United States of America, 103(23), pp. 8668-8673. (doi:10.1073/pnas.0602537103)

Swift, M., and Sutherland, A. (2006) Stereocontrol of palladium(II)-catalysed aza-Claisen rearrangements using a combination of 1,3-allylic strain and a solvent mediated directing effect. Organic and Biomolecular Chemistry, 4, pp. 3889-3891. (doi:10.1039/b613271e)

2005

Bischoff, R., McDonald, N., and Sutherland, A. (2005) A highly efficient, asymmetric synthesis of blastidic acid: the beta-amino acid component of the antibiotic, (+)-blasticidin S. Tetrahedron Letters, 46, pp. 7147-7149. (doi:10.1016/j.tetlet.2005.08.096)

Diaper, C., Sutherland, A., Pillai, B., James, M., Semchuk, P., Blanchard, J., and Vederas, J. (2005) The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase. Organic and Biomolecular Chemistry, 3, pp. 4402-4411. (doi:10.1039/b513409a)

Fanning, K., Jamieson, A., and Sutherland, A. (2005) Stereoselective beta-hydroxy-alpha-amino acid synthesis via an ether-directed, palladium-catalysed aza-Claisen rearrangement. Organic and Biomolecular Chemistry, 3, pp. 3749-3756. (doi:10.1039/b510808j)

Jamieson, A., and Sutherland, A. (2005) A highly stereoselective ether directed palladium catalysed aza-Claisen rearrangement. Organic and Biomolecular Chemistry, 3, pp. 735-736.

2004

Hamilton, D., and Sutherland, A. (2004) A flexible approach for the synthesis of selectively labelled L-arginine. Tetrahedron Letters, 45, pp. 5739-5741. (doi:10.1016/j.tetlet.2004.05.096)

Jamieson, A., Sutherland, A., and Willis, C. (2004) The first enantioselective synthesis of the amino acid, (2S,3S,4R)-gamma-hydroxyisoleucine using a palladium(II) catalysed 3,3-sigmatropic rearrangement. Organic and Biomolecular Chemistry, 2, pp. 808-809. (doi:10.1039/b401076k)

This list was generated on Tue Jun 30 19:55:59 2015 BST.
Number of items: 109.

Articles

Calder, E. D.D., and Sutherland, A. (2015) Enantioselective synthesis of 3-methylene-indan-1-ols via a one-pot allylboration-heck reaction of 2-bromobenzaldehydes. Organic Letters, 17(10), pp. 2514-2517. (doi:10.1021/acs.orglett.5b01047)

Calder, E. D.D., and Sutherland, A. (2015) Enantioselective synthesis of 3-methyleneindan-1-ols via a one-pot allylboration–Heck reaction of 2-bromobenzaldehydes. Organic Letters, 17(10), pp. 2514-2517. (doi:10.1021/acs.orglett.5b01047) (PMID:25933177)

Calder, E. D.D., Sharif, S. A.I., McGonagle, F. I., and Sutherland, A. (2015) One-pot synthesis of 5-amino-2,5-dihydro-1-benzoxepines: access to pharmacologically active heterocyclic scaffolds. Journal of Organic Chemistry, 80(9), pp. 4683-4696. (doi:10.1021/acs.joc.5b00583) (PMID:25847814)

Gilfillan, L., Artschwager, R., Harkiss, A. H., Liskamp, R. M.J., and Sutherland, A. (2015) Synthesis of pyrazole containing α-amino acids via a highly regioselective condensation/aza-Michael reaction of β-aryl α,β-unsaturated ketones. Organic and Biomolecular Chemistry, 13(15), pp. 4514-4523. (doi:10.1039/C5OB00364D) (PMID:25774874)

Reid, C. M., Fanning, K. N., Fowler, L. S., and Sutherland, A. (2015) Synthesis and reactivity of 4-oxo-5-trimethylsilanyl derived α-amino acids. Tetrahedron, 71(2), pp. 245-251. (doi:10.1016/j.tet.2014.11.059)

Blair, A., Zmuda, F., Malviya, G., Chalmers, A. J., Dewar, D., Pimlott, S. L., and Sutherland, A. (2015) A novel 18F-labelled high affinity agent for PET imaging of the translocator protein. Chemical Science, (doi:10.1039/C5SC01647A) (Early Online Publication)

Hill, R. A., and Sutherland, A. (2014) Hot off the press. Natural Product Reports, 31(12), pp. 1671-1675. (doi:10.1039/C4NP90041C)

Grafton, M., Johnson, S. A., Farrugia, L. J., and Sutherland, A. (2014) Diastereoselective synthesis of highly substituted polycyclic scaffolds via a one-pot four-step tandem catalytic process. Tetrahedron Letters, 70(40), pp. 7133-7141. (doi:10.1016/j.tet.2014.06.020)

Hill, R. A., and Sutherland, A. (2014) Hot off the press. Natural Product Reports, 31(10), pp. 1242-1246. (doi:10.1039/C4NP90032D)

Hill, R. A., and Sutherland, A. (2014) Hot off the press. Natural Product Reports, 31(9), pp. 1083-1087. (doi:10.1039/C4NP90023E)

Calder, E. D.D., McGonagle, F. I., Harkiss, A. H., McGonagle, G. A., and Sutherland, A. (2014) Preparation of amino-substituted indenes and 1,4-dihydronaphthalenes using a one-pot multireaction approach: total synthesis of oxybenzo[c]phenanthridine alkaloids. Journal of Organic Chemistry, 79(16), pp. 7633-7648. (doi:10.1021/jo5014492)

Hill, R. A., and Sutherland, A. (2014) Hot off the press. Natural Product Reports, 31(6), pp. 706-710. (doi:10.1039/C4NP90015D)

Calder, E. D.D., Grafton, M. W., and Sutherland, A. (2014) One-pot multi-reaction processes: synthesis of natural products and drug-like scaffolds. Synlett, 25(8), pp. 1068-1080. (doi:10.1055/s-0033-1340683)

Hill, R. A., and Sutherland, A. (2014) Hot off the press. Natural Product Reports, 31(4), pp. 414-418. (doi:10.1039/C4NP90007C)

Hill, R. A., and Sutherland, A. (2014) Hot off the press. Natural Product Reports, 31(4), pp. 414-418. (doi:10.1039/C3NP90044D)

Zaed, A. M., Grafton, M. W., Ahmad, S., and Sutherland, A. (2014) Asymmetric synthesis of cis-aminocyclopentenols, building blocks for medicinal chemistry. Journal of Organic Chemistry, 79(3), pp. 1511-1515. (doi:10.1021/jo402712r)

Hill, R. A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30(12), pp. 1462-1466. (doi:10.1039/C3NP90036C)

Hill, R. A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30(12), pp. 1462-1466. (doi:10.1039/C3NP90029K)

Hill, R. A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30(12), pp. 1074-1078. (doi:10.1039/C3NP90022C)

Cant, A.A., Champion, S., Bhalla, R., Pimlott, S.L., and Sutherland, A. (2013) Nickel-mediated radioiodination of aryl and heteroaryl bromides: rapid synthesis of tracers for SPECT imaging. Angewandte Chemie (International Edition), 52(30), pp. 7829-7832. (doi:10.1002/anie.201302800)

Calder, E.D.D., Zaed, A.M., and Sutherland, A. (2013) Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-Sphinganine, (+)-spisulosine and D-ribo-phytosphingosine. Journal of Organic Chemistry, 78(14), pp. 7223-7233. (doi:10.1021/jo401211j)

Grafton, M. W., Farrugia, L. J., and Sutherland, A. (2013) Synthesis of amino substituted indanes and tetralins via consecutive multi-bond forming tandem processes. Journal of Organic Chemistry, 78(14), pp. 7199-7207. (doi:10.1021/jo401182r)

Gilfillan, L., Blair, A., Morris, B., Pratt, J., Schweiger, L., Pimlott, S., and Sutherland, A. (2013) Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor. MedChemComm, 4(7), pp. 1118-1123. (doi:10.1039/c3md00110e)

Hill, R. A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30(12), pp. 760-764. (doi:10.1039/C3NP90015K)

Hill, R. A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30(12), pp. 485-489. (doi:10.1039/C3NP90007J)

Blair, A., Stevenson, L., Dewar, D., Pimlott, S.L., and Sutherland, A. (2013) Structure–activity relationships of novel iodinated quinoline-2-carboxamides for targeting the translocator protein. MedChemComm, 4(11), pp. 1461-1466. (doi:10.1039/c3md00249g)

Hill, R.A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30(2), pp. 213-217. (doi:10.1039/C2NP90051C)

Blair, A., Stevenson, L., and Sutherland, A. (2012) Synthesis of the isoquinoline alkaloid, crispine C. Tetrahedron Letters, 53(32), pp. 4084-4086. (doi:10.1016/j.tetlet.2012.05.113)

Ahmad, S., Swift, M., Farrugia, L., Senn, H.M., and Sutherland, A. (2012) Stereoselective synthesis of functionalised carbocyclic amides: construction of the syn-(4aS,10bS)-phenanthridone skeleton. Organic and Biomolecular Chemistry, 10(19), pp. 3937-3945. (doi:10.1039/C2OB25334H)

Hill, R., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29(2), p. 129. (doi:10.1039/C1NP90052H)

Ahmad, S., and Sutherland, A. (2012) Stereoselective synthesis of hydroxylated 3-aminoazepanes using a multi-bond forming, three-step tandem process. Organic and Biomolecular Chemistry, 10(41), pp. 8251-8259. (doi:10.1039/C2OB26544C)

Cant, A., Bhalla, R., Pimlott, S.L., and Sutherland, A. (2012) Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides. Chemical Communications, 48(33), pp. 3993-3995. (doi:10.1039/c2cc30956d )

Daly, M., Cant, A.A., Fowler, L.S., Simpson, G.L., Senn, H.M., and Sutherland, A. (2012) Switching the stereochemical outcome of 6-endo-trig cyclizations; Synthesis of 2,6-Cis-6-substituted 4-oxopipecolic acids. Journal of Organic Chemistry, 77(22), pp. 10001-10009. (doi:10.1021/jo3022583)

Grafton, M.W., Farrugia, L.J., Senn, H.M., and Sutherland, A. (2012) Discovery of a multi-bond forming, four-step tandem process: construction of drug-like polycyclic scaffolds. Chemical Communications, 48, pp. 7994-7996. (doi:10.1039/c2cc33649a)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29(4), pp. 435-439. (doi:10.1039/C2NP90008D)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29(6), pp. 617-621. (doi:10.1039/C2NP90016E )

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29(8), p. 829. (doi:10.1039/C2NP90024F)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29(10), pp. 1033-1037. (doi:10.1039/C2NP90033E)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29(12), pp. 1377-1381. (doi:10.1039/C2NP90041F)

Sutherland, A., and Cant, A. (2012) Asymmetric synthesis of pipecolic acid and derivatives. Synthesis, 44(13), pp. 1935-1950. (doi:10.1055/s-0031-1289767)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., Pimlott, S.L., Batis, J., Barret, O., Seibyl, J., and Tamagnan, G. (2012) Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography. Synapse, 66(11), pp. 923-930. (doi:10.1002/syn.21585)

Hill, R., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28(12), p. 1879. (doi:10.1039/C1NP90043A)

Zaed, A., and Sutherland, A. (2011) Total synthesis of clavaminol A, C and H. Organic and Biomolecular Chemistry, 9(23), pp. 8030-8037. (doi:10.1039/C1OB06060K)

Daly, M., Gill, K., Sime, M., Simpson, G.L., and Sutherland, A. (2011) A new general approach for the stereocontrolled synthesis of functionalised γ- and δ-lactams. Organic and Biomolecular Chemistry, 9(19), p. 6761. (doi:10.1039/C1OB05833A)

Fowler, L.S., Thomas, L.H., Ellis, D., and Sutherland, A. (2011) A one-pot reductive amination/6-endo-trig cyclisation for the stereoselective synthesis of 6-substituted-4-oxopipecolic acids. Chemical Communications, 47(23), pp. 6569-6571. (doi:10.1039/c1cc11916h )

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., and Pimlott, S.L. (2011) Development of the radiosynthesis of high-specific-activity 123I-NKJ64. Nuclear Medicine and Biology, 38(4), pp. 493-500. (doi:10.1016/j.nucmedbio.2010.11.011)

Ahmad, S. , Thomas, L.H. , and Sutherland, A. (2011) Stereoselective synthesis of polyhydroxylated aminocyclohexanes. Organic and Biomolecular Chemistry, 9, pp. 2801-2808. (doi:10.1039/C0OB00619J )

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28(6), pp. 1031-1034. (doi:10.1039/C1NP90013G)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28(8), pp. 1345-1349. (doi:10.1039/C1NP90027G)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28(4), pp. 659-662. (doi:10.1039/C1NP90009A)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28(2), pp. 182-185. (doi:10.1039/C0NP90038A)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28(10), pp. 1621-1625. (doi:10.1039/C1NP90035H)

McGonagle, F.I., Brown, L., Cooke, A., and Sutherland, A. (2011) Microwave-promoted tandem reactions for the synthesis of bicyclic γ-lactams. Tetrahedron Letters, 52(18), pp. 2330-2332. (doi:10.1016/j.tetlet.2011.02.089)

Pimlott, S.L., and Sutherland, A. (2011) Molecular tracers for the PET and SPECT imaging of disease. Chemical Society Reviews, 40(1), pp. 149-162. (doi:10.1039/B922628C)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., and Pimlott, S.L. (2011) 123I-NKJ64: A novel single photon emission computed tomography radiotracer for imaging the noradrenaline transporter in brain. Synapse, 65(7), pp. 658-667. (doi:10.1002/syn.20895)

Drummond, L.J., and Sutherland, A. (2010) Asymmetric synthesis of allylic secondary alcohols: a new general approach for the preparation of α-amino acids. Tetrahedron, 66(29), pp. 5349-5356. (doi:10.1016/j.tet.2010.05.066)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27(2), pp. 149-152. (doi:10.1039/B926722K)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27(4), pp. 477-480. (doi:10.1039/C003431M)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27(6), pp. 805-808. (doi:10.1039/C005230M)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27(8), pp. 1110-1113. (doi:10.1039/C005449F)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27(10), pp. 1381-1385. (doi:10.1039/C0NP90017F)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27(12), pp. 1733-1736. (doi:10.1039/C0NP90026E)

Kennedy, A.R., Kerr, W.J., Paterson, L.C., and Sutherland, A. (2010) A Tetrahydropentaleno[1,6a-a]naphthalen-4(2H)-one of Defined Relative Stereochemistry for Use Towards Agariblazeispirol C. Acta Crystallographica. Section D: Biological Crystallography, 66(9), 0473-0474. (doi:10.1107/S0108270110031781 )

McGonagle, F. I., Brown, L., Cooke, A., and Sutherland, A. (2010) A three-step tandem process for the synthesis of bicyclic gamma-lactams. Organic and Biomolecular Chemistry, 8(15), pp. 3418-3425. (doi:10.1039/c004695g )

Stevenson, L., Tavares, A.A.S., Brunet, A., McGonagle, F.I., Dewar, D., Pimlott, S.L., and Sutherland, A. (2010) New iodinated quinloine-2-varboxamides for SPECT imaging of the translocator protein. Bioorganic and Medicinal Chemistry Letters, 20(3), pp. 954-957. (doi:10.1016/j.bmcl.2009.12.061)

Tavares, A., Dewar, D., Sutherland, A., and Pimlott, S. (2010) (R,S)-2-Iodo-reboxetine: Development as a novel SPECT radiotracer for imaging the noradrenaline transporter in brain. Neuroimage, 52, S115-S115. (doi:10.1016/j.neuroimage.2010.04.094)

Zaed, A.M., and Sutherland, A. (2010) Stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin. Organic and Biomolecular Chemistry, 8(19), pp. 4394-4399. (doi:10.1039/C0OB00219D)

Swift, M.D., Donaldson, A., and Sutherland, A. (2009) Tandem aza-Claisen rearrangement and ring closing metathesis reactions: the stereoselective synthesis of functionalised carbocyclic amides. Tetrahedron Letters, 50(26), pp. 3241-3244. (doi:10.1016/j.tetlet.2009.02.032)

Fowler, L.S., Ellis, D., and Sutherland, A. (2009) Synthesis of fluorescent enone derived α-amino acids. Organic and Biomolecular Chemistry, 7(20), pp. 4309-4316. (doi:10.1039/b912782h)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26(2), pp. 151-154. (doi:10.1039/B822940F)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26(4), pp. 461-464. (doi:10.1039/B903591P)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26(6), pp. 725-728. (doi:10.1039/B908225P)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26(8), pp. 973-976. (doi:10.1039/B912059A)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26(10), pp. 1229-1233. (doi:10.1039/B917244K)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26(12), pp. 1517-1520. (doi:10.1039/B921623P)

Jobson, N., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. (2009) Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 19(17), pp. 4996-4998. (doi:10.1016/j.bmcl.2009.07.064)

Zaed, A.M., Swift, M.D., and Sutherland, A. (2009) A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction. Organic and Biomolecular Chemistry, 7(13), pp. 2678-2680. (doi:10.1039/b907341h)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25(6), pp. 997-1000. (doi:10.1039/b818366j)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25(5), pp. 841-844. (doi:10.1039/B814878N)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25(4), pp. 647-650. (doi:10.1039/B810551K)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25(3), pp. 443-446. (doi:10.1039/B806751C)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25(2), pp. 216-219. (doi:10.1039/B803247P)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25(1), pp. 11-14. (doi:10.1039/B719710C)

Jobson, N., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. (2008) New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 18(18), pp. 4940-4943. (doi:10.1016/j.bmcl.2008.08.041)

Jobson, N., Spike, R., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. (2008) Stereoselective synthesis of (2S,3R)- and (2R,3S)-iodoreboxetine; potential SPECT imaging agents for the noradrenaline transporter. Organic and Biomolecular Chemistry, 6(13), pp. 2369-2376. (doi:10.1039/b802819b )

Pimlott, S. L., Stevenson, L., Wyper, D. J., and Sutherland, A. (2008) Rapid and efficient radiosynthesis of [I-123]I-PK11195, a single photon emission computed tomography tracer for peripheral benzodiazepine receptors. Nuclear Medicine and Biology, 35(5), pp. 537-542. (doi:10.1016/j.nucmedbio.2008.02.013)

Swift, M. D., and Sutherland, A. (2008) Studies on the aza-Claisen rearrangement of 4,5-dihydroxylated allylic trichloroacetimidates: the stereoselective synthesis of (2R,3S)- and (2S,3S)-2-amino-3,4-dihydroxybutyric acids. Tetrahedron, 64(40), pp. 9521-9527. (doi:10.1016/j.tet.2008.07.062)

Bischoff, R., Hamilton, D., Jobson, N., and Sutherland, A. (2007) New approaches for the synthesis of isotopically labelled guanidine-derived amino acids and noradrenaline reuptake inhibitors. Journal of Labelled Compounds and Radiopharmaceuticals , 50, pp. 323-326. (doi:10.1002/jlcr.1242)

Fanning, K. N., and Sutherland, A. (2007) A facile synthesis of (S)-gizzerosine, a potent agonist of the histamine H-2-receptor. Tetrahedron Letters, 48(48), pp. 8479-8481. (doi:10.1016/j.tetlet.2007.09.165)

Jamieson, A., and Sutherland, A. (2007) Ether-directed palladium(II)-catalysed aza-Claisen rearrangements: studies on the origin of the directing effect. Tetrahedron, 63, pp. 2123-2131. (doi:10.1016/j.tet.2006.12.067)

Jamieson, A., and Sutherland, A. (2007) Ether-directed, stereoselective aza-Claisen rearrangements: Synthesis of the piperidine alkaloid, alpha-conhydrine. Organic Letters, 9, pp. 1609-1611. (doi:10.1021/ol070424z)

Pillai, B., Cherney, M., Diaper, C., Sutherland, A., Blanchard, J., Vederas, J., and James, M. (2007) Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase. Biochemical and Biophysical Research Communications, 363, pp. 547-553. (doi:10.1016/j.bbrc.2007.09.012)

Stevenson, L., Pimlott, S., and Sutherland, A. (2007) A novel approach for the synthesis of the peripheral benzodiazepine receptor ligand, PK11195. Tetrahedron Letters, 48, pp. 7137-7139. (doi:10.1016/j.tetlet.2007.07.203)

Swift, M. D., and Sutherland, A. (2007) A tandem aza-Claisen rearrangement and ring closing metathesis reaction for the synthesis of cyclic allylic trichloroacetamides. Organic Letters, 9(25), pp. 5239-5242. (doi:10.1021/ol702299c Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland.)

Swift, M., and Sutherland, A. (2007) A stereoselective synthesis of (2R,3S)-2-amino-3,4-dihydroxybutyric acid using an ether directed aza-Claisen rearrangement. Tetrahedron Letters, 48, pp. 3771-3773. (doi:10.1016/j.tetlet.2007.03.161)

Wilson, J., Giordani, F., Farrugia, L., Barrett, M., Robinsa, D., and Sutherland, A. (2007) Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles. Organic and Biomolecular Chemistry, 5, pp. 3651-3656. (doi:10.1039/b710487a)

Wilson, J., Henderson, G., Black, F., Sutherland, A., Ludwig, R., Vousden, K., and Robins, D. (2007) Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells. Bioorganic and Medicinal Chemistry Letters, 15, pp. 77-86. (doi:10.1016/j.bmc.2006.10.011)

Fanning, K., Jamieson, A., and Sutherland, A. (2006) Palladium(II)-catalysed rearrangement reactions. Current Organic Chemistry, 10, pp. 1007-1020.

Jamieson, A., and Sutherland, A. (2006) Scope and limitations of ether-directed, metal-catalysed aza-Claisen rearrangements; improved stereoselectivity using non-coordinating solvents. Organic and Biomolecular Chemistry, 4, pp. 2932-2937. (doi:10.1039/b607014k)

Pillai, B., Cherney, M., Diaper, C., Sutherland, A., Blanchard, J., Vederas, J., and James, M. (2006) Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proceedings of the National Academy of Sciences of the United States of America, 103(23), pp. 8668-8673. (doi:10.1073/pnas.0602537103)

Swift, M., and Sutherland, A. (2006) Stereocontrol of palladium(II)-catalysed aza-Claisen rearrangements using a combination of 1,3-allylic strain and a solvent mediated directing effect. Organic and Biomolecular Chemistry, 4, pp. 3889-3891. (doi:10.1039/b613271e)

Bischoff, R., McDonald, N., and Sutherland, A. (2005) A highly efficient, asymmetric synthesis of blastidic acid: the beta-amino acid component of the antibiotic, (+)-blasticidin S. Tetrahedron Letters, 46, pp. 7147-7149. (doi:10.1016/j.tetlet.2005.08.096)

Diaper, C., Sutherland, A., Pillai, B., James, M., Semchuk, P., Blanchard, J., and Vederas, J. (2005) The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase. Organic and Biomolecular Chemistry, 3, pp. 4402-4411. (doi:10.1039/b513409a)

Fanning, K., Jamieson, A., and Sutherland, A. (2005) Stereoselective beta-hydroxy-alpha-amino acid synthesis via an ether-directed, palladium-catalysed aza-Claisen rearrangement. Organic and Biomolecular Chemistry, 3, pp. 3749-3756. (doi:10.1039/b510808j)

Jamieson, A., and Sutherland, A. (2005) A highly stereoselective ether directed palladium catalysed aza-Claisen rearrangement. Organic and Biomolecular Chemistry, 3, pp. 735-736.

Hamilton, D., and Sutherland, A. (2004) A flexible approach for the synthesis of selectively labelled L-arginine. Tetrahedron Letters, 45, pp. 5739-5741. (doi:10.1016/j.tetlet.2004.05.096)

Jamieson, A., Sutherland, A., and Willis, C. (2004) The first enantioselective synthesis of the amino acid, (2S,3S,4R)-gamma-hydroxyisoleucine using a palladium(II) catalysed 3,3-sigmatropic rearrangement. Organic and Biomolecular Chemistry, 2, pp. 808-809. (doi:10.1039/b401076k)

Book Sections

Fowler, L.S., Sutherland, A., Procter, J., and Molander, G.A. (2011) Product class 6: acyclic and semicyclic o/o acetals. In: Ishihara, K., Krause, N. and Procter, D. (eds.) Science of Synthesis Knowledge Updates. Thieme, p. 121. ISBN 9783131541611

Reid., C.M., and Sutherland, A. (2009) Synthesis of isotopically labeled α-amino acids. In: Hughes, A.B. (ed.) Amino Acids, Peptides and Proteins in Organic Chemistry. Vol. 1. Origins and Synthesis of Amino Acids. Wiley-VCH: Weinham, Germany. ISBN 9783527320967

This list was generated on Tue Jun 30 19:55:59 2015 BST.