Research in the Sutherland group focuses on the development and understanding of new organic reactions with particular emphasis on using transition metal catalysis to create new chiral molecules. Once developed, we then apply our new chemistry to the total synthesis of biologically active and medicinally important compounds and natural products. In collaboration with biologists, neuroscientists and clinical physicists we also test the biological properties and study the potential applications of our new compounds.
Pericyclic Rearrangements Organometallic Chemistry Total Synthesis of N-Heterocycle Containing Natural Products SPECT and PET Imaging Tracers for Neurological Receptors Synthesis of Non-Proteinogenic Amino Acids
A. A. Cant, S. Champion, R. Bhalla, S. L. Pimlott and A. Sutherland, Nickel-Mediated Radioiodination of Aryl and Heteroaryl Bromides: Rapid Synthesis of Tracers for SPECT Imaging, Angew. Chem. Int. Ed., 2013, 52, 7829-7832.
E. D. D. Calder, A. M. Zaed and A. Sutherland, Preparation of anti-Vicinal Amino Alcohols: Asymmetric Synthesis of D-erythyro-Sphinganine, (+)-Spisulosine and D-ribo-Phytosphingosine, J. Org. Chem., 2013, 78, 7223-7233.
M. Daly, A. A. Cant, L. S. Fowler, G. L. Simpson, H. M. Senn and A. Sutherland, Switching the Stereochemical Outcome of 6-Endo-Trig Cyclizations; Synthesis of 2,6-Cis-6-Substituted 4-Oxopipecolic Acids, J. Org. Chem., 2012, 77, 10001-10009.
M. W. Grafton, L. J. Farrugia, H. M. Senn and A. Sutherland, Discovery of a Multi-Bond Forming, Four-step Tandem Process: Construction of Drug-Like Polycyclic Scaffolds, Chem. Commun., 2012, 48, 7994-7996.
A. A. Cant, R. Bhalla, S. L. Pimlott and A. Sutherland, Nickel-Catalysed Aromatic Finkelstein Reaction of Aryl and Heteroaryl Bromides, Chem. Commun., 2012, 48, 3993-3995.