Dr Andrew Sutherland

Andrew Sutherland
  • Senior Lecturer (Chemistry)

telephone: 01413305936
email: Andrew.Sutherland@glasgow.ac.uk

C5-07
Chemistry
Joseph Black Building
Glasgow G12 8QQ


obc2011Research Interests

Research in the Sutherland group focuses on the development and understanding of new organic reactions with particular emphasis on using transition metal catalysis to create new chiral molecules. Once developed, we then apply our new chemistry to the total synthesis of biologically active and medicinally important compounds and natural products. In collaboration with biologists, neuroscientists and clinical physicists we also test the biological properties and study the potential applications of our new compounds.

obc2010Research Topics

Pericyclic Rearrangements
Organometallic Chemistry
Total Synthesis of N-Heterocycle Containing Natural Products
SPECT and PET Imaging Tracers for Neurological Receptors
Synthesis of Non-Proteinogenic Amino Acids

Publication Highlights

  • A. A. Cant, S. Champion, R. Bhalla, S. L. Pimlott and A. Sutherland, Nickel-Mediated Radioiodination of Aryl and Heteroaryl Bromides: Rapid Synthesis of Tracers for SPECT Imaging, Angew. Chem. Int. Ed., 2013, 52, 7829-7832.
  • E. D. D. Calder, A. M. Zaed and A. Sutherland, Preparation of anti-Vicinal Amino Alcohols: Asymmetric Synthesis of D-erythyro-Sphinganine, (+)-Spisulosine and D-ribo-Phytosphingosine, J. Org. Chem., 2013, 78, 7223-7233.
  • M. Daly, A. A. Cant, L. S. Fowler, G. L. Simpson, H. M. Senn and A. Sutherland, Switching the Stereochemical Outcome of 6-Endo-Trig Cyclizations; Synthesis of 2,6-Cis-6-Substituted 4-Oxopipecolic Acids, J. Org. Chem., 2012, 77, 10001-10009.
  • M. W. Grafton, L. J. Farrugia, H. M. Senn and A. Sutherland, Discovery of a Multi-Bond Forming, Four-step Tandem Process: Construction of Drug-Like Polycyclic Scaffolds, Chem. Commun., 2012, 48, 7994-7996.
  • A. A. Cant, R. Bhalla, S. L. Pimlott and A. Sutherland, Nickel-Catalysed Aromatic Finkelstein Reaction of Aryl and Heteroaryl Bromides, Chem. Commun., 2012, 48, 3993-3995.

Sutherland group 2013-2014 

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Number of items: 89.

2014

Calder, E. D.D., Grafton, M. W., and Sutherland, A. (2014) One-pot multi-reaction processes: synthesis of natural products and drug-like scaffolds. Synlett, 25 (8). pp. 1068-1080. ISSN 0936-5214 (doi:10.1055/s-0033-1340683)

Calder, E. D.D., McGonagle, F. I., Harkiss, A. H., McGonagle, G. A., and Sutherland, A. (2014) Preparation of amino-substituted indenes and 1,4-dihydronaphthalenes using a one-pot multireaction approach: total synthesis of oxybenzo[c]phenanthridine alkaloids. Journal of Organic Chemistry . ISSN 0022-3263 (doi:10.1021/jo5014492) (Early Online Publication)

2013

Cant, A.A., Champion, S., Bhalla, R., Pimlott, S.L., and Sutherland, A. (2013) Nickel-mediated radioiodination of aryl and heteroaryl bromides: rapid synthesis of tracers for SPECT imaging. Angewandte Chemie (International Edition), 52 (30). pp. 7829-7832. ISSN 1433-7851 (doi:10.1002/anie.201302800)

Calder, E.D.D., Zaed, A.M., and Sutherland, A. (2013) Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-Sphinganine, (+)-spisulosine and D-ribo-phytosphingosine. Journal of Organic Chemistry, 78 (14). pp. 7223-7233. ISSN 0022-3263 (doi:10.1021/jo401211j)

Grafton, M. W., Farrugia, L. J., and Sutherland, A. (2013) Synthesis of amino substituted indanes and tetralins via consecutive multi-bond forming tandem processes. Journal of Organic Chemistry, 78 (14). pp. 7199-7207. ISSN 0022-3263 (doi:10.1021/jo401182r)

Gilfillan, L., Blair, A., Morris, B., Pratt, J., Schweiger, L., Pimlott, S., and Sutherland, A. (2013) Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor. MedChemComm, 4 (7). pp. 1118-1123. ISSN 2040-2503 (doi:10.1039/c3md00110e)

Hill, R.A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30 (2). pp. 213-217. ISSN 0265-0568 (doi:10.1039/C2NP90051C)

2012

Blair, A., Stevenson, L., and Sutherland, A. (2012) Synthesis of the isoquinoline alkaloid, crispine C. Tetrahedron Letters, 53 (32). pp. 4084-4086. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.113)

Ahmad, S., Swift, M., Farrugia, L., Senn, H.M., and Sutherland, A. (2012) Stereoselective synthesis of functionalised carbocyclic amides: construction of the syn-(4aS,10bS)-phenanthridone skeleton. Organic and Biomolecular Chemistry, 10 (19). pp. 3937-3945. ISSN 1477-0520 (doi:10.1039/C2OB25334H)

Hill, R., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29 (2). p. 129. ISSN 0265-0568 (doi:10.1039/C1NP90052H)

Ahmad, S., and Sutherland, A. (2012) Stereoselective synthesis of hydroxylated 3-aminoazepanes using a multi-bond forming, three-step tandem process. Organic and Biomolecular Chemistry, 10 (41). pp. 8251-8259. ISSN 1477-0520 (doi:10.1039/C2OB26544C)

Cant, A., Bhalla, R., Pimlott, S.L., and Sutherland, A. (2012) Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides. Chemical Communications, 48 (33). pp. 3993-3995. ISSN 1359-7345 (doi:10.1039/c2cc30956d )

Daly, M., Cant, A.A., Fowler, L.S., Simpson, G.L., Senn, H.M., and Sutherland, A. (2012) Switching the stereochemical outcome of 6-endo-trig cyclizations; Synthesis of 2,6-Cis-6-substituted 4-oxopipecolic acids. Journal of Organic Chemistry, 77 (22). pp. 10001-10009. ISSN 0022-3263 (doi:10.1021/jo3022583)

Grafton, M.W., Farrugia, L.J., Senn, H.M., and Sutherland, A. (2012) Discovery of a multi-bond forming, four-step tandem process: construction of drug-like polycyclic scaffolds. Chemical Communications, 48 . pp. 7994-7996. ISSN 1359-7345 (doi:10.1039/c2cc33649a)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29 (4). pp. 435-439. ISSN 0265-0568 (doi:10.1039/C2NP90008D)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29 (6). pp. 617-621. ISSN 0265-0568 (doi:10.1039/C2NP90016E )

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29 (8). p. 829. ISSN 0265-0568 (doi:10.1039/C2NP90024F)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29 (10). pp. 1033-1037. ISSN 0265-0568 (doi:10.1039/C2NP90033E)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29 (12). pp. 1377-1381. ISSN 0265-0568 (doi:10.1039/C2NP90041F)

Sutherland, A., and Cant, A. (2012) Asymmetric synthesis of pipecolic acid and derivatives. Synthesis, 44 (13). pp. 1935-1950. ISSN 0039-7881 (doi:10.1055/s-0031-1289767)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., Pimlott, S.L., Batis, J., Barret, O., Seibyl, J., and Tamagnan, G. (2012) Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography. Synapse, 66 (11). pp. 923-930. ISSN 0887-4476 (doi:10.1002/syn.21585)

2011

Hill, R., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28 (12). p. 1879. ISSN 0265-0568 (doi:10.1039/C1NP90043A)

Zaed, A., and Sutherland, A. (2011) Total synthesis of clavaminol A, C and H. Organic and Biomolecular Chemistry, 9 (23). pp. 8030-8037. ISSN 1477-0520 (doi:10.1039/C1OB06060K)

Daly, M., Gill, K., Sime, M., Simpson, G.L., and Sutherland, A. (2011) A new general approach for the stereocontrolled synthesis of functionalised γ- and δ-lactams. Organic and Biomolecular Chemistry, 9 (19). p. 6761. ISSN 1477-0520 (doi:10.1039/C1OB05833A)

Fowler, L.S., Thomas, L.H., Ellis, D., and Sutherland, A. (2011) A one-pot reductive amination/6-endo-trig cyclisation for the stereoselective synthesis of 6-substituted-4-oxopipecolic acids. Chemical Communications, 47 (23). pp. 6569-6571. ISSN 1359-7345 (doi:10.1039/c1cc11916h )

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., and Pimlott, S.L. (2011) Development of the radiosynthesis of high-specific-activity 123I-NKJ64. Nuclear Medicine and Biology, 38 (4). pp. 493-500. ISSN 0969-8051 (doi:10.1016/j.nucmedbio.2010.11.011)

Fowler, L.S., Sutherland, A., Procter, J., and Molander, G.A. (2011) Product class 6: acyclic and semicyclic o/o acetals. In: Ishihara, K., Krause, N. and Procter, D. (eds.) Science of Synthesis Knowledge Updates. Thieme, p. 121. ISBN 9783131541611

Ahmad, S. , Thomas, L.H. , and Sutherland, A. (2011) Stereoselective synthesis of polyhydroxylated aminocyclohexanes. Organic and Biomolecular Chemistry, 9 . pp. 2801-2808. ISSN 1477-0520 (doi:10.1039/C0OB00619J )

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28 (6). pp. 1031-1034. ISSN 0265-0568 (doi:10.1039/C1NP90013G)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28 (8). pp. 1345-1349. ISSN 0265-0568 (doi:10.1039/C1NP90027G)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28 (4). pp. 659-662. ISSN 0265-0568 (doi:10.1039/C1NP90009A)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28 (2). pp. 182-185. ISSN 0265-0568 (doi:10.1039/C0NP90038A)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28 (10). pp. 1621-1625. ISSN 0265-0568 (doi:10.1039/C1NP90035H)

McGonagle, F.I., Brown, L., Cooke, A., and Sutherland, A. (2011) Microwave-promoted tandem reactions for the synthesis of bicyclic γ-lactams. Tetrahedron Letters, 52 (18). pp. 2330-2332. ISSN 0040-4039 (doi:10.1016/j.tetlet.2011.02.089)

Pimlott, S.L., and Sutherland, A. (2011) Molecular tracers for the PET and SPECT imaging of disease. Chemical Society Reviews, 40 (1). pp. 149-162. ISSN 0306-0012 (doi:10.1039/B922628C)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., and Pimlott, S.L. (2011) 123I-NKJ64: A novel single photon emission computed tomography radiotracer for imaging the noradrenaline transporter in brain. Synapse, 65 (7). pp. 658-667. ISSN 0887-4476 (doi:10.1002/syn.20895)

2010

Drummond, L.J., and Sutherland, A. (2010) Asymmetric synthesis of allylic secondary alcohols: a new general approach for the preparation of α-amino acids. Tetrahedron, 66 (29). pp. 5349-5356. ISSN 0040-4020 (doi:10.1016/j.tet.2010.05.066)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27 (2). pp. 149-152. ISSN 0265-0568 (doi:10.1039/B926722K)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27 (4). pp. 477-480. ISSN 0265-0568 (doi:10.1039/C003431M)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27 (6). pp. 805-808. ISSN 0265-0568 (doi:10.1039/C005230M)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27 (8). pp. 1110-1113. ISSN 0265-0568 (doi:10.1039/C005449F)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27 (10). pp. 1381-1385. ISSN 0265-0568 (doi:10.1039/C0NP90017F)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27 (12). pp. 1733-1736. ISSN 0265-0568 (doi:10.1039/C0NP90026E)

Kennedy, A.R., Kerr, W.J., Paterson, L.C., and Sutherland, A. (2010) A Tetrahydropentaleno[1,6a-a]naphthalen-4(2H)-one of Defined Relative Stereochemistry for Use Towards Agariblazeispirol C. Acta Crystallographica. Section D: Biological Crystallography, 66 (9). 0473-0474. ISSN 0907-4449 (doi:10.1107/S0108270110031781 )

McGonagle, F. I., Brown, L., Cooke, A., and Sutherland, A. (2010) A three-step tandem process for the synthesis of bicyclic gamma-lactams. Organic and Biomolecular Chemistry, 8 (15). pp. 3418-3425. ISSN 1477-0520 (doi:10.1039/c004695g )

Stevenson, L., Tavares, A.A.S., Brunet, A., McGonagle, F.I., Dewar, D., Pimlott, S.L., and Sutherland, A. (2010) New iodinated quinloine-2-varboxamides for SPECT imaging of the translocator protein. Bioorganic and Medicinal Chemistry Letters, 20 (3). pp. 954-957. ISSN 0960-894X (doi:10.1016/j.bmcl.2009.12.061)

Tavares, A., Dewar, D., Sutherland, A., and Pimlott, S. (2010) (R,S)-2-Iodo-reboxetine: Development as a novel SPECT radiotracer for imaging the noradrenaline transporter in brain. Neuroimage, 52 . S115-S115. ISSN 1053-8119 (doi:10.1016/j.neuroimage.2010.04.094)

Zaed, A.M., and Sutherland, A. (2010) Stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin. Organic and Biomolecular Chemistry, 8 (19). pp. 4394-4399. ISSN 1477-0520 (doi:10.1039/C0OB00219D)

2009

Swift, M.D., Donaldson, A., and Sutherland, A. (2009) Tandem aza-Claisen rearrangement and ring closing metathesis reactions: the stereoselective synthesis of functionalised carbocyclic amides. Tetrahedron Letters, 50 (26). pp. 3241-3244. ISSN 0040-4039 (doi:10.1016/j.tetlet.2009.02.032)

Fowler, L.S., Ellis, D., and Sutherland, A. (2009) Synthesis of fluorescent enone derived α-amino acids. Organic and Biomolecular Chemistry, 7 (20). pp. 4309-4316. ISSN 1477-0520 (doi:10.1039/b912782h)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26 (2). pp. 151-154. ISSN 0265-0568 (doi:10.1039/B822940F)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26 (4). pp. 461-464. ISSN 0265-0568 (doi:10.1039/B903591P)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26 (6). pp. 725-728. ISSN 0265-0568 (doi:10.1039/B908225P)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26 (8). pp. 973-976. ISSN 0265-0568 (doi:10.1039/B912059A)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26 (10). pp. 1229-1233. ISSN 0265-0568 (doi:10.1039/B917244K)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26 (12). pp. 1517-1520. ISSN 0265-0568 (doi:10.1039/B921623P)

Jobson, N., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. (2009) Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 19 (17). pp. 4996-4998. ISSN 0960-894X (doi:10.1016/j.bmcl.2009.07.064)

Reid., C.M., and Sutherland, A. (2009) Synthesis of isotopically labeled α-amino acids. In: Hughes, A.B. (ed.) Amino Acids, Peptides and Proteins in Organic Chemistry. Vol. 1. Origins and Synthesis of Amino Acids. Wiley-VCH, Weinham, Germany. ISBN 9783527320967

Zaed, A.M., Swift, M.D., and Sutherland, A. (2009) A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction. Organic and Biomolecular Chemistry, 7 (13). pp. 2678-2680. ISSN 1477-0520 (doi:10.1039/b907341h)

2008

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25 (6). pp. 997-1000. ISSN 0265-0568 (doi:10.1039/b818366j)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25 (5). pp. 841-844. ISSN 0265-0568 (doi:10.1039/B814878N)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25 (4). pp. 647-650. ISSN 0265-0568 (doi:10.1039/B810551K)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25 (3). pp. 443-446. ISSN 0265-0568 (doi:10.1039/B806751C)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25 (2). pp. 216-219. ISSN 0265-0568 (doi:10.1039/B803247P)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25 (1). pp. 11-14. ISSN 0265-0568 (doi:10.1039/B719710C)

Jobson, N., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. (2008) New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 18 (18). pp. 4940-4943. ISSN 0960-894X (doi:10.1016/j.bmcl.2008.08.041)

Jobson, N., Spike, R., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. (2008) Stereoselective synthesis of (2S,3R)- and (2R,3S)-iodoreboxetine; potential SPECT imaging agents for the noradrenaline transporter. Organic and Biomolecular Chemistry, 6 (13). pp. 2369-2376. ISSN 1477-0520 (doi:10.1039/b802819b )

Pimlott, S. L., Stevenson, L., Wyper, D. J., and Sutherland, A. (2008) Rapid and efficient radiosynthesis of [I-123]I-PK11195, a single photon emission computed tomography tracer for peripheral benzodiazepine receptors. Nuclear Medicine and Biology, 35 (5). pp. 537-542. ISSN 0969-8051 (doi:10.1016/j.nucmedbio.2008.02.013)

Swift, M. D., and Sutherland, A. (2008) Studies on the aza-Claisen rearrangement of 4,5-dihydroxylated allylic trichloroacetimidates: the stereoselective synthesis of (2R,3S)- and (2S,3S)-2-amino-3,4-dihydroxybutyric acids. Tetrahedron, 64 (40). pp. 9521-9527. ISSN 0040-4020 (doi:10.1016/j.tet.2008.07.062)

2007

Bischoff, R., Hamilton, D., Jobson, N., and Sutherland, A. (2007) New approaches for the synthesis of isotopically labelled guanidine-derived amino acids and noradrenaline reuptake inhibitors. Journal of Labelled Compounds and Radiopharmaceuticals , 50 . pp. 323-326. (doi:10.1002/jlcr.1242)

Fanning, K. N., and Sutherland, A. (2007) A facile synthesis of (S)-gizzerosine, a potent agonist of the histamine H-2-receptor. Tetrahedron Letters, 48 (48). pp. 8479-8481. ISSN 0040-4039 (doi:10.1016/j.tetlet.2007.09.165)

Jamieson, A., and Sutherland, A. (2007) Ether-directed palladium(II)-catalysed aza-Claisen rearrangements: studies on the origin of the directing effect. Tetrahedron, 63 . pp. 2123-2131. (doi:10.1016/j.tet.2006.12.067)

Jamieson, A., and Sutherland, A. (2007) Ether-directed, stereoselective aza-Claisen rearrangements: Synthesis of the piperidine alkaloid, alpha-conhydrine. Organic Letters, 9 . pp. 1609-1611. (doi:10.1021/ol070424z)

Pillai, B., Cherney, M., Diaper, C., Sutherland, A., Blanchard, J., Vederas, J., and James, M. (2007) Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase. Biochemical and Biophysical Research Communications, 363 . pp. 547-553. ISSN 0006-291X (doi:10.1016/j.bbrc.2007.09.012)

Stevenson, L., Pimlott, S., and Sutherland, A. (2007) A novel approach for the synthesis of the peripheral benzodiazepine receptor ligand, PK11195. Tetrahedron Letters, 48 . pp. 7137-7139. (doi:10.1016/j.tetlet.2007.07.203)

Swift, M. D., and Sutherland, A. (2007) A tandem aza-Claisen rearrangement and ring closing metathesis reaction for the synthesis of cyclic allylic trichloroacetamides. Organic Letters, 9 (25). pp. 5239-5242. ISSN 1523-7060 (doi:10.1021/ol702299c Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland.)

Swift, M., and Sutherland, A. (2007) A stereoselective synthesis of (2R,3S)-2-amino-3,4-dihydroxybutyric acid using an ether directed aza-Claisen rearrangement. Tetrahedron Letters, 48 . pp. 3771-3773. (doi:10.1016/j.tetlet.2007.03.161)

Wilson, J., Giordani, F., Farrugia, L., Barrett, M., Robinsa, D., and Sutherland, A. (2007) Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles. Organic and Biomolecular Chemistry, 5 . pp. 3651-3656. (doi:10.1039/b710487a)

Wilson, J., Henderson, G., Black, F., Sutherland, A., Ludwig, R., Vousden, K., and Robins, D. (2007) Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells. Bioorganic and Medicinal Chemistry Letters, 15 . pp. 77-86. ISSN 0960-894X (doi:10.1016/j.bmc.2006.10.011)

2006

Fanning, K., Jamieson, A., and Sutherland, A. (2006) Palladium(II)-catalysed rearrangement reactions. Current Organic Chemistry, 10 . pp. 1007-1020.

Jamieson, A., and Sutherland, A. (2006) Scope and limitations of ether-directed, metal-catalysed aza-Claisen rearrangements; improved stereoselectivity using non-coordinating solvents. Organic and Biomolecular Chemistry, 4 . pp. 2932-2937. (doi:10.1039/b607014k)

Pillai, B., Cherney, M., Diaper, C., Sutherland, A., Blanchard, J., Vederas, J., and James, M. (2006) Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proceedings of the National Academy of Sciences of the United States of America, 103 (23). pp. 8668-8673. ISSN 0027-8424 (doi:10.1073/pnas.0602537103)

Swift, M., and Sutherland, A. (2006) Stereocontrol of palladium(II)-catalysed aza-Claisen rearrangements using a combination of 1,3-allylic strain and a solvent mediated directing effect. Organic and Biomolecular Chemistry, 4 . pp. 3889-3891. (doi:10.1039/b613271e)

2005

Bischoff, R., McDonald, N., and Sutherland, A. (2005) A highly efficient, asymmetric synthesis of blastidic acid: the beta-amino acid component of the antibiotic, (+)-blasticidin S. Tetrahedron Letters, 46 . pp. 7147-7149. (doi:10.1016/j.tetlet.2005.08.096)

Diaper, C., Sutherland, A., Pillai, B., James, M., Semchuk, P., Blanchard, J., and Vederas, J. (2005) The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase. Organic and Biomolecular Chemistry, 3 . pp. 4402-4411. (doi:10.1039/b513409a)

Fanning, K., Jamieson, A., and Sutherland, A. (2005) Stereoselective beta-hydroxy-alpha-amino acid synthesis via an ether-directed, palladium-catalysed aza-Claisen rearrangement. Organic and Biomolecular Chemistry, 3 . pp. 3749-3756. (doi:10.1039/b510808j)

Jamieson, A., and Sutherland, A. (2005) A highly stereoselective ether directed palladium catalysed aza-Claisen rearrangement. Organic and Biomolecular Chemistry, 3 . pp. 735-736.

2004

Hamilton, D., and Sutherland, A. (2004) A flexible approach for the synthesis of selectively labelled L-arginine. Tetrahedron Letters, 45 . pp. 5739-5741. (doi:10.1016/j.tetlet.2004.05.096)

Jamieson, A., Sutherland, A., and Willis, C. (2004) The first enantioselective synthesis of the amino acid, (2S,3S,4R)-gamma-hydroxyisoleucine using a palladium(II) catalysed 3,3-sigmatropic rearrangement. Organic and Biomolecular Chemistry, 2 . pp. 808-809. (doi:10.1039/b401076k)

This list was generated on Sat Oct 25 01:42:12 2014 BST.
Number of items: 89.

Article

Calder, E. D.D., Grafton, M. W., and Sutherland, A. (2014) One-pot multi-reaction processes: synthesis of natural products and drug-like scaffolds. Synlett, 25 (8). pp. 1068-1080. ISSN 0936-5214 (doi:10.1055/s-0033-1340683)

Calder, E. D.D., McGonagle, F. I., Harkiss, A. H., McGonagle, G. A., and Sutherland, A. (2014) Preparation of amino-substituted indenes and 1,4-dihydronaphthalenes using a one-pot multireaction approach: total synthesis of oxybenzo[c]phenanthridine alkaloids. Journal of Organic Chemistry . ISSN 0022-3263 (doi:10.1021/jo5014492) (Early Online Publication)

Cant, A.A., Champion, S., Bhalla, R., Pimlott, S.L., and Sutherland, A. (2013) Nickel-mediated radioiodination of aryl and heteroaryl bromides: rapid synthesis of tracers for SPECT imaging. Angewandte Chemie (International Edition), 52 (30). pp. 7829-7832. ISSN 1433-7851 (doi:10.1002/anie.201302800)

Calder, E.D.D., Zaed, A.M., and Sutherland, A. (2013) Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-Sphinganine, (+)-spisulosine and D-ribo-phytosphingosine. Journal of Organic Chemistry, 78 (14). pp. 7223-7233. ISSN 0022-3263 (doi:10.1021/jo401211j)

Grafton, M. W., Farrugia, L. J., and Sutherland, A. (2013) Synthesis of amino substituted indanes and tetralins via consecutive multi-bond forming tandem processes. Journal of Organic Chemistry, 78 (14). pp. 7199-7207. ISSN 0022-3263 (doi:10.1021/jo401182r)

Gilfillan, L., Blair, A., Morris, B., Pratt, J., Schweiger, L., Pimlott, S., and Sutherland, A. (2013) Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor. MedChemComm, 4 (7). pp. 1118-1123. ISSN 2040-2503 (doi:10.1039/c3md00110e)

Hill, R.A., and Sutherland, A. (2013) Hot off the press. Natural Product Reports, 30 (2). pp. 213-217. ISSN 0265-0568 (doi:10.1039/C2NP90051C)

Blair, A., Stevenson, L., and Sutherland, A. (2012) Synthesis of the isoquinoline alkaloid, crispine C. Tetrahedron Letters, 53 (32). pp. 4084-4086. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.113)

Ahmad, S., Swift, M., Farrugia, L., Senn, H.M., and Sutherland, A. (2012) Stereoselective synthesis of functionalised carbocyclic amides: construction of the syn-(4aS,10bS)-phenanthridone skeleton. Organic and Biomolecular Chemistry, 10 (19). pp. 3937-3945. ISSN 1477-0520 (doi:10.1039/C2OB25334H)

Hill, R., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29 (2). p. 129. ISSN 0265-0568 (doi:10.1039/C1NP90052H)

Ahmad, S., and Sutherland, A. (2012) Stereoselective synthesis of hydroxylated 3-aminoazepanes using a multi-bond forming, three-step tandem process. Organic and Biomolecular Chemistry, 10 (41). pp. 8251-8259. ISSN 1477-0520 (doi:10.1039/C2OB26544C)

Cant, A., Bhalla, R., Pimlott, S.L., and Sutherland, A. (2012) Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides. Chemical Communications, 48 (33). pp. 3993-3995. ISSN 1359-7345 (doi:10.1039/c2cc30956d )

Daly, M., Cant, A.A., Fowler, L.S., Simpson, G.L., Senn, H.M., and Sutherland, A. (2012) Switching the stereochemical outcome of 6-endo-trig cyclizations; Synthesis of 2,6-Cis-6-substituted 4-oxopipecolic acids. Journal of Organic Chemistry, 77 (22). pp. 10001-10009. ISSN 0022-3263 (doi:10.1021/jo3022583)

Grafton, M.W., Farrugia, L.J., Senn, H.M., and Sutherland, A. (2012) Discovery of a multi-bond forming, four-step tandem process: construction of drug-like polycyclic scaffolds. Chemical Communications, 48 . pp. 7994-7996. ISSN 1359-7345 (doi:10.1039/c2cc33649a)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29 (4). pp. 435-439. ISSN 0265-0568 (doi:10.1039/C2NP90008D)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29 (6). pp. 617-621. ISSN 0265-0568 (doi:10.1039/C2NP90016E )

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29 (8). p. 829. ISSN 0265-0568 (doi:10.1039/C2NP90024F)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29 (10). pp. 1033-1037. ISSN 0265-0568 (doi:10.1039/C2NP90033E)

Hill, R.A., and Sutherland, A. (2012) Hot off the press. Natural Product Reports, 29 (12). pp. 1377-1381. ISSN 0265-0568 (doi:10.1039/C2NP90041F)

Sutherland, A., and Cant, A. (2012) Asymmetric synthesis of pipecolic acid and derivatives. Synthesis, 44 (13). pp. 1935-1950. ISSN 0039-7881 (doi:10.1055/s-0031-1289767)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., Pimlott, S.L., Batis, J., Barret, O., Seibyl, J., and Tamagnan, G. (2012) Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography. Synapse, 66 (11). pp. 923-930. ISSN 0887-4476 (doi:10.1002/syn.21585)

Hill, R., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28 (12). p. 1879. ISSN 0265-0568 (doi:10.1039/C1NP90043A)

Zaed, A., and Sutherland, A. (2011) Total synthesis of clavaminol A, C and H. Organic and Biomolecular Chemistry, 9 (23). pp. 8030-8037. ISSN 1477-0520 (doi:10.1039/C1OB06060K)

Daly, M., Gill, K., Sime, M., Simpson, G.L., and Sutherland, A. (2011) A new general approach for the stereocontrolled synthesis of functionalised γ- and δ-lactams. Organic and Biomolecular Chemistry, 9 (19). p. 6761. ISSN 1477-0520 (doi:10.1039/C1OB05833A)

Fowler, L.S., Thomas, L.H., Ellis, D., and Sutherland, A. (2011) A one-pot reductive amination/6-endo-trig cyclisation for the stereoselective synthesis of 6-substituted-4-oxopipecolic acids. Chemical Communications, 47 (23). pp. 6569-6571. ISSN 1359-7345 (doi:10.1039/c1cc11916h )

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., and Pimlott, S.L. (2011) Development of the radiosynthesis of high-specific-activity 123I-NKJ64. Nuclear Medicine and Biology, 38 (4). pp. 493-500. ISSN 0969-8051 (doi:10.1016/j.nucmedbio.2010.11.011)

Ahmad, S. , Thomas, L.H. , and Sutherland, A. (2011) Stereoselective synthesis of polyhydroxylated aminocyclohexanes. Organic and Biomolecular Chemistry, 9 . pp. 2801-2808. ISSN 1477-0520 (doi:10.1039/C0OB00619J )

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28 (6). pp. 1031-1034. ISSN 0265-0568 (doi:10.1039/C1NP90013G)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28 (8). pp. 1345-1349. ISSN 0265-0568 (doi:10.1039/C1NP90027G)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28 (4). pp. 659-662. ISSN 0265-0568 (doi:10.1039/C1NP90009A)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28 (2). pp. 182-185. ISSN 0265-0568 (doi:10.1039/C0NP90038A)

Hill, R.A., and Sutherland, A. (2011) Hot off the press. Natural Product Reports, 28 (10). pp. 1621-1625. ISSN 0265-0568 (doi:10.1039/C1NP90035H)

McGonagle, F.I., Brown, L., Cooke, A., and Sutherland, A. (2011) Microwave-promoted tandem reactions for the synthesis of bicyclic γ-lactams. Tetrahedron Letters, 52 (18). pp. 2330-2332. ISSN 0040-4039 (doi:10.1016/j.tetlet.2011.02.089)

Pimlott, S.L., and Sutherland, A. (2011) Molecular tracers for the PET and SPECT imaging of disease. Chemical Society Reviews, 40 (1). pp. 149-162. ISSN 0306-0012 (doi:10.1039/B922628C)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., and Pimlott, S.L. (2011) 123I-NKJ64: A novel single photon emission computed tomography radiotracer for imaging the noradrenaline transporter in brain. Synapse, 65 (7). pp. 658-667. ISSN 0887-4476 (doi:10.1002/syn.20895)

Drummond, L.J., and Sutherland, A. (2010) Asymmetric synthesis of allylic secondary alcohols: a new general approach for the preparation of α-amino acids. Tetrahedron, 66 (29). pp. 5349-5356. ISSN 0040-4020 (doi:10.1016/j.tet.2010.05.066)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27 (2). pp. 149-152. ISSN 0265-0568 (doi:10.1039/B926722K)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27 (4). pp. 477-480. ISSN 0265-0568 (doi:10.1039/C003431M)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27 (6). pp. 805-808. ISSN 0265-0568 (doi:10.1039/C005230M)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27 (8). pp. 1110-1113. ISSN 0265-0568 (doi:10.1039/C005449F)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27 (10). pp. 1381-1385. ISSN 0265-0568 (doi:10.1039/C0NP90017F)

Hill, R.A., and Sutherland, A. (2010) Hot off the press. Natural Product Reports, 27 (12). pp. 1733-1736. ISSN 0265-0568 (doi:10.1039/C0NP90026E)

Kennedy, A.R., Kerr, W.J., Paterson, L.C., and Sutherland, A. (2010) A Tetrahydropentaleno[1,6a-a]naphthalen-4(2H)-one of Defined Relative Stereochemistry for Use Towards Agariblazeispirol C. Acta Crystallographica. Section D: Biological Crystallography, 66 (9). 0473-0474. ISSN 0907-4449 (doi:10.1107/S0108270110031781 )

McGonagle, F. I., Brown, L., Cooke, A., and Sutherland, A. (2010) A three-step tandem process for the synthesis of bicyclic gamma-lactams. Organic and Biomolecular Chemistry, 8 (15). pp. 3418-3425. ISSN 1477-0520 (doi:10.1039/c004695g )

Stevenson, L., Tavares, A.A.S., Brunet, A., McGonagle, F.I., Dewar, D., Pimlott, S.L., and Sutherland, A. (2010) New iodinated quinloine-2-varboxamides for SPECT imaging of the translocator protein. Bioorganic and Medicinal Chemistry Letters, 20 (3). pp. 954-957. ISSN 0960-894X (doi:10.1016/j.bmcl.2009.12.061)

Tavares, A., Dewar, D., Sutherland, A., and Pimlott, S. (2010) (R,S)-2-Iodo-reboxetine: Development as a novel SPECT radiotracer for imaging the noradrenaline transporter in brain. Neuroimage, 52 . S115-S115. ISSN 1053-8119 (doi:10.1016/j.neuroimage.2010.04.094)

Zaed, A.M., and Sutherland, A. (2010) Stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin. Organic and Biomolecular Chemistry, 8 (19). pp. 4394-4399. ISSN 1477-0520 (doi:10.1039/C0OB00219D)

Swift, M.D., Donaldson, A., and Sutherland, A. (2009) Tandem aza-Claisen rearrangement and ring closing metathesis reactions: the stereoselective synthesis of functionalised carbocyclic amides. Tetrahedron Letters, 50 (26). pp. 3241-3244. ISSN 0040-4039 (doi:10.1016/j.tetlet.2009.02.032)

Fowler, L.S., Ellis, D., and Sutherland, A. (2009) Synthesis of fluorescent enone derived α-amino acids. Organic and Biomolecular Chemistry, 7 (20). pp. 4309-4316. ISSN 1477-0520 (doi:10.1039/b912782h)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26 (2). pp. 151-154. ISSN 0265-0568 (doi:10.1039/B822940F)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26 (4). pp. 461-464. ISSN 0265-0568 (doi:10.1039/B903591P)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26 (6). pp. 725-728. ISSN 0265-0568 (doi:10.1039/B908225P)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26 (8). pp. 973-976. ISSN 0265-0568 (doi:10.1039/B912059A)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26 (10). pp. 1229-1233. ISSN 0265-0568 (doi:10.1039/B917244K)

Hill, R.A., and Sutherland, A. (2009) Hot off the press. Natural Product Reports, 26 (12). pp. 1517-1520. ISSN 0265-0568 (doi:10.1039/B921623P)

Jobson, N., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. (2009) Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 19 (17). pp. 4996-4998. ISSN 0960-894X (doi:10.1016/j.bmcl.2009.07.064)

Zaed, A.M., Swift, M.D., and Sutherland, A. (2009) A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction. Organic and Biomolecular Chemistry, 7 (13). pp. 2678-2680. ISSN 1477-0520 (doi:10.1039/b907341h)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25 (6). pp. 997-1000. ISSN 0265-0568 (doi:10.1039/b818366j)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25 (5). pp. 841-844. ISSN 0265-0568 (doi:10.1039/B814878N)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25 (4). pp. 647-650. ISSN 0265-0568 (doi:10.1039/B810551K)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25 (3). pp. 443-446. ISSN 0265-0568 (doi:10.1039/B806751C)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25 (2). pp. 216-219. ISSN 0265-0568 (doi:10.1039/B803247P)

Hill, R.A., and Sutherland, A. (2008) Hot off the press. Natural Product Reports, 25 (1). pp. 11-14. ISSN 0265-0568 (doi:10.1039/B719710C)

Jobson, N., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. (2008) New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 18 (18). pp. 4940-4943. ISSN 0960-894X (doi:10.1016/j.bmcl.2008.08.041)

Jobson, N., Spike, R., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A. (2008) Stereoselective synthesis of (2S,3R)- and (2R,3S)-iodoreboxetine; potential SPECT imaging agents for the noradrenaline transporter. Organic and Biomolecular Chemistry, 6 (13). pp. 2369-2376. ISSN 1477-0520 (doi:10.1039/b802819b )

Pimlott, S. L., Stevenson, L., Wyper, D. J., and Sutherland, A. (2008) Rapid and efficient radiosynthesis of [I-123]I-PK11195, a single photon emission computed tomography tracer for peripheral benzodiazepine receptors. Nuclear Medicine and Biology, 35 (5). pp. 537-542. ISSN 0969-8051 (doi:10.1016/j.nucmedbio.2008.02.013)

Swift, M. D., and Sutherland, A. (2008) Studies on the aza-Claisen rearrangement of 4,5-dihydroxylated allylic trichloroacetimidates: the stereoselective synthesis of (2R,3S)- and (2S,3S)-2-amino-3,4-dihydroxybutyric acids. Tetrahedron, 64 (40). pp. 9521-9527. ISSN 0040-4020 (doi:10.1016/j.tet.2008.07.062)

Bischoff, R., Hamilton, D., Jobson, N., and Sutherland, A. (2007) New approaches for the synthesis of isotopically labelled guanidine-derived amino acids and noradrenaline reuptake inhibitors. Journal of Labelled Compounds and Radiopharmaceuticals , 50 . pp. 323-326. (doi:10.1002/jlcr.1242)

Fanning, K. N., and Sutherland, A. (2007) A facile synthesis of (S)-gizzerosine, a potent agonist of the histamine H-2-receptor. Tetrahedron Letters, 48 (48). pp. 8479-8481. ISSN 0040-4039 (doi:10.1016/j.tetlet.2007.09.165)

Jamieson, A., and Sutherland, A. (2007) Ether-directed palladium(II)-catalysed aza-Claisen rearrangements: studies on the origin of the directing effect. Tetrahedron, 63 . pp. 2123-2131. (doi:10.1016/j.tet.2006.12.067)

Jamieson, A., and Sutherland, A. (2007) Ether-directed, stereoselective aza-Claisen rearrangements: Synthesis of the piperidine alkaloid, alpha-conhydrine. Organic Letters, 9 . pp. 1609-1611. (doi:10.1021/ol070424z)

Pillai, B., Cherney, M., Diaper, C., Sutherland, A., Blanchard, J., Vederas, J., and James, M. (2007) Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase. Biochemical and Biophysical Research Communications, 363 . pp. 547-553. ISSN 0006-291X (doi:10.1016/j.bbrc.2007.09.012)

Stevenson, L., Pimlott, S., and Sutherland, A. (2007) A novel approach for the synthesis of the peripheral benzodiazepine receptor ligand, PK11195. Tetrahedron Letters, 48 . pp. 7137-7139. (doi:10.1016/j.tetlet.2007.07.203)

Swift, M. D., and Sutherland, A. (2007) A tandem aza-Claisen rearrangement and ring closing metathesis reaction for the synthesis of cyclic allylic trichloroacetamides. Organic Letters, 9 (25). pp. 5239-5242. ISSN 1523-7060 (doi:10.1021/ol702299c Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland.)

Swift, M., and Sutherland, A. (2007) A stereoselective synthesis of (2R,3S)-2-amino-3,4-dihydroxybutyric acid using an ether directed aza-Claisen rearrangement. Tetrahedron Letters, 48 . pp. 3771-3773. (doi:10.1016/j.tetlet.2007.03.161)

Wilson, J., Giordani, F., Farrugia, L., Barrett, M., Robinsa, D., and Sutherland, A. (2007) Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles. Organic and Biomolecular Chemistry, 5 . pp. 3651-3656. (doi:10.1039/b710487a)

Wilson, J., Henderson, G., Black, F., Sutherland, A., Ludwig, R., Vousden, K., and Robins, D. (2007) Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells. Bioorganic and Medicinal Chemistry Letters, 15 . pp. 77-86. ISSN 0960-894X (doi:10.1016/j.bmc.2006.10.011)

Fanning, K., Jamieson, A., and Sutherland, A. (2006) Palladium(II)-catalysed rearrangement reactions. Current Organic Chemistry, 10 . pp. 1007-1020.

Jamieson, A., and Sutherland, A. (2006) Scope and limitations of ether-directed, metal-catalysed aza-Claisen rearrangements; improved stereoselectivity using non-coordinating solvents. Organic and Biomolecular Chemistry, 4 . pp. 2932-2937. (doi:10.1039/b607014k)

Pillai, B., Cherney, M., Diaper, C., Sutherland, A., Blanchard, J., Vederas, J., and James, M. (2006) Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proceedings of the National Academy of Sciences of the United States of America, 103 (23). pp. 8668-8673. ISSN 0027-8424 (doi:10.1073/pnas.0602537103)

Swift, M., and Sutherland, A. (2006) Stereocontrol of palladium(II)-catalysed aza-Claisen rearrangements using a combination of 1,3-allylic strain and a solvent mediated directing effect. Organic and Biomolecular Chemistry, 4 . pp. 3889-3891. (doi:10.1039/b613271e)

Bischoff, R., McDonald, N., and Sutherland, A. (2005) A highly efficient, asymmetric synthesis of blastidic acid: the beta-amino acid component of the antibiotic, (+)-blasticidin S. Tetrahedron Letters, 46 . pp. 7147-7149. (doi:10.1016/j.tetlet.2005.08.096)

Diaper, C., Sutherland, A., Pillai, B., James, M., Semchuk, P., Blanchard, J., and Vederas, J. (2005) The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase. Organic and Biomolecular Chemistry, 3 . pp. 4402-4411. (doi:10.1039/b513409a)

Fanning, K., Jamieson, A., and Sutherland, A. (2005) Stereoselective beta-hydroxy-alpha-amino acid synthesis via an ether-directed, palladium-catalysed aza-Claisen rearrangement. Organic and Biomolecular Chemistry, 3 . pp. 3749-3756. (doi:10.1039/b510808j)

Jamieson, A., and Sutherland, A. (2005) A highly stereoselective ether directed palladium catalysed aza-Claisen rearrangement. Organic and Biomolecular Chemistry, 3 . pp. 735-736.

Hamilton, D., and Sutherland, A. (2004) A flexible approach for the synthesis of selectively labelled L-arginine. Tetrahedron Letters, 45 . pp. 5739-5741. (doi:10.1016/j.tetlet.2004.05.096)

Jamieson, A., Sutherland, A., and Willis, C. (2004) The first enantioselective synthesis of the amino acid, (2S,3S,4R)-gamma-hydroxyisoleucine using a palladium(II) catalysed 3,3-sigmatropic rearrangement. Organic and Biomolecular Chemistry, 2 . pp. 808-809. (doi:10.1039/b401076k)

Book Section

Fowler, L.S., Sutherland, A., Procter, J., and Molander, G.A. (2011) Product class 6: acyclic and semicyclic o/o acetals. In: Ishihara, K., Krause, N. and Procter, D. (eds.) Science of Synthesis Knowledge Updates. Thieme, p. 121. ISBN 9783131541611

Reid., C.M., and Sutherland, A. (2009) Synthesis of isotopically labeled α-amino acids. In: Hughes, A.B. (ed.) Amino Acids, Peptides and Proteins in Organic Chemistry. Vol. 1. Origins and Synthesis of Amino Acids. Wiley-VCH, Weinham, Germany. ISBN 9783527320967

This list was generated on Sat Oct 25 01:42:12 2014 BST.

Teaching

  • Level-2 Isomerism and Stereochemistry
  • Level-3 Organic Synthesis 1
  • Level-3 Biotransformations 1 and 2
  • Level-4 Pericyclic Reactions

Awards

BSc (Edinburgh) PhD (Bristol) MRSC CChem

Selected Recent Talks

  • "New Stereoselective Synthesis of N-Heterocycles". Departmental Seminar, ICSN, CNRS, Gif-sur-Yvette, March 2011. 
  • "New Stereoselective Rearrangement Processes for the Synthesis of Natural Products". Departmental Seminar, Universite Pierre et Marie Curie, March 2011. 
  • "Stereoselective Rearrangements for the Preparation of Natural Products". Wilson Baker Symposium, University of Bristol, March, 2011. 
  • "New Stereoselective Rearrangement Processes for the Synthesis of Natural Products". Research Seminar, Almac Discovery, Northern Ireland, January 2011. 
  • "The Stereoselective Synthesis of Iodinated Analogues of Reboxetine for SPECT Imaging the Noradrenaline Transporter". 42nd IUPAC Congress, Glasgow, August 2009.

External Appointments & Positions

  • External Examiner in Chemistry for GlaxoSmithKline/University of Kent
  • EPSRC College and Panel Member
  • Member of the Board of Tetrahedron Letters
  • Member of the SINAPSE Molecular Imaging Committee
  • Member of the Tetrahedron Referee Panel