Research in the Sutherland group is focused on a number of key areas. Our main programme of research centres on molecular imaging of disease. We have a number of projects that develop novel PET and SPECT tracers for the radionuclide imaging of a range of neurological diseases as well as cancer. We are also investigating amino acid based fluorescent probes for cell imaging. Supporting these projects is a synthetic chemistry programme, which seeks to develop new transition metal catalysed transformations and one-pot multi-reaction processes for the rapid preparation of polycyclic drug-like scaffolds and natural products.
PET and SPECT Imaging Agents
Fluorescent Amino Acids
Transition metal catalysed reactions
One-pot multi-reaction processes
D. T. Racys, S. A. I. Sharif, S. L. Pimlott and A. Sutherland, Silver(I)-Catalyzed Iodination of Arenes: Tuning the Lewis Acidity of N-Iodosuccinimide Activation, J. Org. Chem., 2016, 81, 772-780.
D. T. Racys, C. E. Warrilow, S. L. Pimlott and A. Sutherland, Highly Regioselective Iodination of Arenes via Iron(III)-Catalyzed Activation of N-Iodosuccinimide, Org. Lett., 2015, 17, 4782-4785.
A. Blair, F. Zmuda, G. Malviya, A. A. S. Tavares, G. D. Tamagnan, A. J. Chalmers, D. Dewar, S. L. Pimlott and A. Sutherland, A Novel 18F-Labelled High Affinity Agent for PET Imaging of the Translocator Protein, Chem. Sci., 2015, 6, 4772-4777.
E. D. D. Calder and A. Sutherland, Enantioselective Synthesis of 3-Methyleneindan-1-ols via a One-Pot Allylboration-Heck Reaction of 2-Bromobenzaldehydes, Org. Lett., 2015, 17, 2514-2517.
A. A. Cant, S. Champion, R. Bhalla, S. L. Pimlott and A. Sutherland, Nickel-Mediated Radioiodination of Aryl and Heteroaryl Bromides: Rapid Synthesis of Tracers for SPECT Imaging, Angew. Chem. Int. Ed., 2013, 52, 7829-7832.