Dr Adrian Lapthorn

  • Senior Lecturer (Chemistry)

telephone: 01413305940
email: Adrian.Lapthorn@glasgow.ac.uk

Research interests

Research Interests

My research interests are in using the technique of protein crystallography to elucidate protein structure with an aim to answering important questions on protein function and mechanism. I also have a specific interest in protein-protein interactions. Protein Structure and Function; Enzymes of the Shikimate pathway; Structure aided drug discovery; Protein Crystallography; Plant Glutathione S-transferases.

More details are available on the personal Research Pages.

Research Topics

Protein Structure and Function
Enzymes of the Shikimate pathway
Structure aided drug discovery
Protein Crystallography
Plant Glutathione S-transferases

Publication Highlights

"Binding and glutathione conjugation of porphyrinogens by plant glutathione transferases". Dixon, D.P., Lapthorn, A.J., Madesis, P., Mudd, E.A., Day, A. and Edwards, R. J. Biol. Chem. 283, 20268-20276 (2008)

"Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases". Payne, R.J., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A.D., Lapthorn, A.J. and Abell, C. ChemMedChem, 2, 1010-1013 (2007)

"Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: New directions for inhibitor design". D.A. Robinson, K.A. Stewart, N.C. Price, P.A. Chalk, J.R. Coggins, A.J. Lapthorn, J. Med. Chem., 49, 1282-1290 (2006)

"Crystal structure of mouse succinic semialdehyde reductase AKR7A5: Structural basis for substrate specificity". X.F. Zhu, A.J. Lapthorn, E.M. Ellis, Biochemistry, 45, 1562-1570 (2006)

"The structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of substrate binding sites and mode of AMP inhibition". B. Lohkamp, G. McDermott, S.A. Campbell, J.R. Coggins, A.J. Lapthorn, J. Mol. Biol., 336, 131-144 (2004)

 

 

Teaching

Teaching

Science Fundamentals:- Aqueous Solutions Science Fundamentals:- Reaction Kinetics
Level-1 Chemistry:- Attractions and Repulsions
Level-3 Chemistry:- Biophysical Chemistry

Additional information

Awards

PhD (York)

 

Publications

List by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2011 | 2010 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993
Number of items: 52.

2016

Berger, P., and Lapthorn, A. J. (2016) The molecular relationship between antigenic domains and epitopes on hCG. Molecular Immunology, 76, pp. 134-145. (doi:10.1016/j.molimm.2016.06.015) (PMID:27450517)

González-Jiminéz, M., Ramakrishnan, G., Harwood, T., Lapthorn, A. J., Kelly, S. M., Ellis, E. M., and Wynne, K. (2016) Observation of coherent delocalized phonon-like modes in DNA under physiological conditions. Nature Communications, 7, 11799. (doi:10.1038/ncomms11799) (PMID:27248361)

Berger, P., and Lapthorn, A. (2016) Standardization of Epitopes for human chorionic gonadotropin (hCG) Immunoassays. Current Medicinal Chemistry, 23(30), pp. 3481-3494. (doi:10.2174/0929867323666160530145503) (PMID:27237818)

Jack, C. et al. (2016) Spatial control of chemical processes on nanostructures through nano-localised water heating. Nature Communications, 7, 10946. (doi:10.1038/ncomms10946) (PMID:26961708)

2015

Tullius, R., Karimullah, A. S., Rodier, M., Fitzpatrick, B., Gadegaard, N., Barron, L. D., Rotello, V. M., Cooke, G., Lapthorn, A., and Kadodwala, M. (2015) "Superchiral” spectroscopy: detection of protein higher order hierarchical structure with chiral plasmonic nanostructures. Journal of the American Chemical Society, 137(26), pp. 8380-8383. (doi:10.1021/jacs.5b04806) (PMID:26102606)

2014

Turton, D. A., Senn, H., Harwood, T., Lapthorn, A. J., Ellis, E. M., and Wynne, K. (2014) Terahertz underdamped vibrational motion governs protein-ligand binding in solution. Nature Communications, 5, p. 3999. (doi:10.1038/ncomms4999)

2013

Turton, D., Harwood, T., Lapthorn, A., Ellis, E., and Wynne, K. (2013) Ultrabroadband terahertz spectroscopies of biomolecules and water. Proceedings of the SPIE: The International Society for Optical Engineering, 8623(862303), (doi:10.1117/12.2003796)

Lapthorn, A. J., Zhu, X., and Ellis, E. M. (2013) The diversity of microbial aldo/keto reductases from Escherichia coli K12. Chemico-Biological Interactions, 202(1-3), pp. 168-177. (doi:10.1016/j.cbi.2012.10.008) (PMID:23103600)

2011

Paz, S. et al. (2011) Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase. ChemMedChem, 6(2), pp. 266-272. (doi:10.1002/cmdc.201000343)

Tran, A.T., Cergol, K.M., West, N.P., Randall, E.J., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J., and Payne, R.J. (2011) Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem, 6(2), pp. 262-265. (doi:10.1002/cmdc.201000399)

2010

Hendry, E., Carpy, T., Johnston, J., Popland, M., Mikhaylovskiy, R.V., Lapthorn, A., Kelly, S.M., Barron, L.D., Gadegaard, N., and Kadodwala, M. (2010) Ultrasensitive detection and characterization of biomolecules using superchiral fields. Nature Nanotechnology, 5(11), pp. 783-787. (doi:10.1038/nnano.2010.209)

Tran, A.T., Cergol, K.M., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J., and Payne, R.J. (2010) Rapid assembly of potent type II dehydroquinase inhibitors via "Click" chemistry. MedChemComm, 1(4), pp. 271-275. (doi:10.1039/c0md00097c)

2008

Dixon, D. P., Lapthorn, A., Madesis, P., Mudd, E. A., Day, A., and Edwards, R. (2008) Binding and glutathione conjugation of porphyrinogens by plant glutathione transferases. Journal of Biological Chemistry, 283(29), pp. 20268-20276. (doi:10.1074/jbc.M802026200)

Stewart, K. A., Robinson, D. A., and Lapthorn, A. J. (2008) Type II dehydroquinase: molecular replacement with many copies. Acta Crystallographica. Section D: Biological Crystallography, 64, pp. 108-118. (doi:10.1107/S0907444907054923)

2007

Payne, R.J., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A.D., Lapthorn, A.J., and Abell, C. (2007) Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases. ChemMedChem, 2(7), pp. 1010-1013. (doi:10.1002/cmdc.200700062)

Prazeres, V. F.V., Sanchez-Sixto, C., Castedo, L., Lamb, H., Hawkins, A. R., Riboldi-Tunnicliffe, A., Coggins, J. R., Lapthorn, A. J., and Gonzalez-Bello, C. (2007) Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase. ChemMedChem, 2(2), pp. 194-207. (doi:10.1002/cmdc.200600208)

2006

Lohkamp, B., Paterson, N., and Lapthorn, A. (2006) Application of a new vector system for efficient protein purification in the crystallization of PA5104/ORF from Pseudomonas aeruginosa. Journal of Structural Biology, 155, pp. 111-113. (doi:10.1016/j.jsb.2006.03.016)

Robinson, D.A.,, Stewart, K.A., Price, N.C., Chalk, P.A., Coggins, J.R., and Lapthorn, A.J. (2006) Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design. Journal of Medicinal Chemistry, 49(4), pp. 1282-1290. (doi:10.1021/jm0505361)

Zhu, X., Lapthorn, A., and Ellis, E. (2006) Crystal structure of mouse succinic semialdehyde reductase AKR7A5: Structural basis for substrate specificity. Biochemistry, 45, pp. 1562-1570. (doi:10.1021/bi051610k)

2005

Dias-Gunasekara, S., Gubbens, J., van Lith, M., Dunne, C., Williams, J.A.G., Kataky, R., Scoones, D., Lapthorn, A., Bulleid, N.J., and Benham, A.M. (2005) Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1β. Journal of Biological Chemistry, 280, pp. 33066-33075. (doi:10.1074/jbc.M505023200)

Charrel-Dennis, M. et al. (2005) The human chorionic gonadotropin-beta arginine(68) to glutamic acid substitution fixes the conformation of the C-terminal peptide. Molecular Endocrinology, 19, pp. 1803-1811. (doi:10.1210/me.2004-0109)

Dixon, D., Lapthorn, A., and Edwards, R. (2005) Synthesis and analysis of chimeric maize glutathione transferases. Plant Science, 168, pp. 873-881. (doi:10.1016/j.plantsci.2004.11.009)

Toscano, M.D., Stewart, K.A., Coggins, J.R., Lapthorn, A.J., and Abell, C. (2005) Rational design of new bifunctional inhibitors of type II dehydroquinase. Organic and Biomolecular Chemistry, 3, pp. 3102-3104. (doi:10.1039/B507156A)

2004

Lohkamp, B., McDermott, G., Campbell, S.A., Coggins, J.R., and Lapthorn, A.J. (2004) The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition. Journal of Molecular Biology, 336(1), pp. 131-144. (doi:10.1016/j.jmb.2003.12.020)

Charrel-Dennis, M., Jackson, A., Lund, T., Lapthorn, A., Berger, P., Roitt, I., and Delves, P. (2004) The major hormone-specific discontinuous epitopes on human chorionic gonadotrophin. Journal of Molecular Endocrinology, 32, pp. 571-581.

Frederickson, M., Roszak, A. W., Coggins, J. R., Lapthorn, A. J., and Abell, C. (2004) (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases. Organic and Biomolecular Chemistry, 2(11), pp. 1592-1596. (doi:10.1039/B404535A)

2003

Coggins, J.R., Abell, C., Evan, L.B., Frederickson, M., Robinson, D.A., Roszak, A.W., and Lapthorn, A.P. (2003) Experiences with the Shikimate-pathway enzymes as targets for rational drug design. Biochemical Society Transactions, 31(3), pp. 548-552.

Cerasoli, E., Kelly, S.M., Coggins, J.R., Lapthorn, A.J., Clarke, D.T., and Price, N.C. (2003) Effects of salts on the function and conformational stability of shikimate kinase. Biochimica et Biophysica Acta: Proteins and Proteomics, 1648(1-2), pp. 43-54. (doi:10.1016/S1570-9639(03)00110-9)

Michel, G., Roszak, A.W., Sauve, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M., and Lapthorn, A.J. (2003) Structures of Shikimate dehydrogenase AroE and its paralog YdiB: a common structural framework for different activities. Journal of Biological Chemistry, 278, pp. 19463-19472. (doi:10.1074/jbc.M300794200)

Dixon, D., McEwen, A., Lapthorn, A., and Edwards, R. (2003) Forced evolution of a herbicide detoxifying glutathione transferase. Journal of Biological Chemistry, 278, pp. 23930-23935. (doi:10.1074/jbc.M303620200)

Kozma, E., Brown, E., Ellis, E.M., and Lapthorn, A.J. (2003) The high resolution crystal structure of rat liver AKR7A1: understanding the substrate specificites of the AKR7 family. Chemico-Biological Interactions, 143, pp. 289-297.

2002

Evans, L. D.B., Roszak, A. W., Noble, L. J., Robinson, D. A., Chalk, P. A., Matthews, J. L., Coggins, J. R., Price, N. C., and Lapthorn, A. J. (2002) Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions. FEBS Letters, 530(1-3), pp. 24-30. (doi:10.1016/S0014-5793(02)03346-X)

Roszak, A.W., Robinson, D.A., Krell, T., Hunter, I.S., Fredrickson, M., Abell, C., Coggins, J.R., and Lapthorn, A.J. (2002) The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. Structure, 10(4), pp. 493-503. (doi:10.1016/S0969-2126(02)00747-5)

Dixon, D. P., Lapthorn, A., and Edwards, R. (2002) Plant glutathione transferases. Genome Biology, 3(3), reviews300. (doi:10.1186/gb-2002-3-3-reviews3004) (PMID:11897031) (PMCID:PMC139027)

Kozma, E., Brown, E., Ellis, E., and Lapthorn, A. (2002) The crystal structure of rat liver AKR7A1 - A dimeric member of the aldo-keto reductase superfamily. Journal of Biological Chemistry, 277, pp. 16285-16293. (doi:10.1074/jbc.M110808200)

Thom, R., Cummins, I., Dixon, D., Edwards, R., Cole, D., and Lapthorn, A. (2002) Structure of a tau class glutathione S-transferase from wheat active in herbicide detoxification. Biochemistry, 41, pp. 7008-7020. (doi:10.1021/bi015964x)

2001

Krell, T., Maclean, J., Boam, D.J., Cooper, A., Resmini, M., Brocklehurst, K., Kelly, S.M., Price, N.C., Lapthorn, A.J., and Coggins, J.R. (2001) Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine. Protein Science, 10(6), pp. 1137-1149. (doi:10.1110/ps.52501)

Thom, R., Dixon, D., Edwards, R., Cole, D., and Lapthorn, A. (2001) The structure of a zeta class glutathione S-transferase from Arabidopsis thaliana: Characterisation of a GST with novel active-site architecture and a putative role in tyrosine catabolism. Journal of Molecular Biology, 308, pp. 949-962. (doi:10.1006/jmbi.2001.4638)

Thom, R., Dixon, D., Edwards, R., Cole, D., and Lapthorn, A. (2001) Structure determination of zeta class glutathione transferase from Arabidopsis thaliana. Chemico-Biological Interactions, 133, pp. 53-54.

2000

Maclean, J., Campbell, S. A., Pollock, K., Chackrewarthy, S., Coggins, J. R., and Lapthorn, A. J. (2000) Crystallization and preliminary X-ray analysis of shikimate dehydrogenase fromEscherichia coli. Acta Crystallographica Section D: Biological Crystallography, 56(4), pp. 512-515. (doi:10.1107/S0907444900002377)

1998

Krell, T., Coggins, J. R., and Lapthorn, A. J. (1998) The three-dimensional structure of shikimate kinase. Journal of Molecular Biology, 278(5), pp. 983-997. (doi:10.1006/jmbi.1998.1755) (PMID:9600856)

1997

Idziak, C., Price, N. C., Kelly, S. M., Krell, T., Boam, D. J., Lapthorn, A. J., and Coggins, J. R. (1997) 93 The interaction of shikimate kinase fromErwinia chrystanthemiwith substrates. Biochemical Society Transactions, 25(4), S627-S627. (doi:10.1042/bst025s627)

Krell, T., Coyle, J. E., Horsburgh, M. J., Coggins, J. R., and Lapthorn, A. J. (1997) Crystallization and preliminary X-ray crystallographic analysis of shikimate kinase fromErwinia chrysanthemi. Acta Crystallographica Section D: Biological Crystallography, 53(5), pp. 612-614. (doi:10.1107/S0907444997004319)

1996

Berger, P. et al. (1996) Immunochemical mapping of gonadotropins. Molecular and Cellular Endocrinology, 125(1-2), pp. 33-43. (doi:10.1016/S0303-7207(96)03943-3)

Bhowmick, N., Huang, J., Puett, D., Isaacs, N.W., and Lapthorn, A.J. (1996) Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling. Molecular Endocrinology, 10(9), pp. 1147-1159. (doi:10.1210/mend.10.9.8885249)

Jackson, A. M., Klonisch, T., Lapthorn, A. J., Berger, P., Isaacs, N. W., Delves, P. J., Lund, T., and Roitt, I. M. (1996) Identification and selective destruction of shared epitopes in human chorionic gonadotropin beta subunit. Journal of Reproductive Immunology, 31(1-2), pp. 21-36. (doi:10.1016/0165-0378(96)00978-3)

Klonisch, T., Delves, P. J., Berger, P., Panayotou, G., Lapthorn, A. J., Isaacs, N. W., Wick, G., Lund, T., and Roitt, I. M. (1996) Relative location of epitopes involved in synergistic antibody binding using human chorionic gonadotropin as a model. European Journal of Immunology, 26(8), pp. 1897-1905. (doi:10.1002/eji.1830260834) (PMID:8765037)

1995

Lapthorn, A.J., Janes, R. W., Isaacs, N.W., and Wallace, B.A. (1995) Cystine nooses and protein specificity. Nature Structural Biology, 2(4), pp. 266-268. (doi:10.1038/nsb0495-266) (PMID:7796259)

1994

Lapthorn, A. J., Harris, D. C., Littlejohn, A., Lustbader, J. W., Canfield, R. E., Machin, K. J., Morgan, F. J., and Isaacs, N. W. (1994) Crystal structure of human chorionic gonadotropin. Nature, 369(6480), pp. 455-461. (doi:10.1038/369455a0) (PMID:8202136)

1993

Guillet, V., Lapthorn, A., Hartley, R.W., and Mauguen, Y. (1993) Recognition between a bacterial ribonuclease, barnase, and its natural inhibitor, barstar. Structure, 1(3), pp. 165-176. (doi:10.1016/0969-2126(93)90018-C) (PMID:16100951)

Guillet, V., Lapthorn, A., and Mauguen, Y. (1993) Three-dimensional structure of a barnase-3'GMP complex at 2.2Å resolution. FEBS Letters, 330(2), pp. 137-140. (doi:10.1016/0014-5793(93)80259-W) (PMID:8396045)

Guillet, V., Lapthorn, A., Fourniat, J., Benoit, J.-P., Hartley, R. W., and Mauguen, Y. (1993) Crystallization and prelilminary X-ray investigation of barster, the intracellular inhibitor of barnase. Proteins, 17(3), pp. 325-328. (doi:10.1002/prot.340170309) (PMID:8272429)

This list was generated on Mon Apr 24 16:42:42 2017 BST.
Jump to: Articles
Number of items: 52.

Articles

Berger, P., and Lapthorn, A. J. (2016) The molecular relationship between antigenic domains and epitopes on hCG. Molecular Immunology, 76, pp. 134-145. (doi:10.1016/j.molimm.2016.06.015) (PMID:27450517)

González-Jiminéz, M., Ramakrishnan, G., Harwood, T., Lapthorn, A. J., Kelly, S. M., Ellis, E. M., and Wynne, K. (2016) Observation of coherent delocalized phonon-like modes in DNA under physiological conditions. Nature Communications, 7, 11799. (doi:10.1038/ncomms11799) (PMID:27248361)

Berger, P., and Lapthorn, A. (2016) Standardization of Epitopes for human chorionic gonadotropin (hCG) Immunoassays. Current Medicinal Chemistry, 23(30), pp. 3481-3494. (doi:10.2174/0929867323666160530145503) (PMID:27237818)

Jack, C. et al. (2016) Spatial control of chemical processes on nanostructures through nano-localised water heating. Nature Communications, 7, 10946. (doi:10.1038/ncomms10946) (PMID:26961708)

Tullius, R., Karimullah, A. S., Rodier, M., Fitzpatrick, B., Gadegaard, N., Barron, L. D., Rotello, V. M., Cooke, G., Lapthorn, A., and Kadodwala, M. (2015) "Superchiral” spectroscopy: detection of protein higher order hierarchical structure with chiral plasmonic nanostructures. Journal of the American Chemical Society, 137(26), pp. 8380-8383. (doi:10.1021/jacs.5b04806) (PMID:26102606)

Turton, D. A., Senn, H., Harwood, T., Lapthorn, A. J., Ellis, E. M., and Wynne, K. (2014) Terahertz underdamped vibrational motion governs protein-ligand binding in solution. Nature Communications, 5, p. 3999. (doi:10.1038/ncomms4999)

Turton, D., Harwood, T., Lapthorn, A., Ellis, E., and Wynne, K. (2013) Ultrabroadband terahertz spectroscopies of biomolecules and water. Proceedings of the SPIE: The International Society for Optical Engineering, 8623(862303), (doi:10.1117/12.2003796)

Lapthorn, A. J., Zhu, X., and Ellis, E. M. (2013) The diversity of microbial aldo/keto reductases from Escherichia coli K12. Chemico-Biological Interactions, 202(1-3), pp. 168-177. (doi:10.1016/j.cbi.2012.10.008) (PMID:23103600)

Paz, S. et al. (2011) Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase. ChemMedChem, 6(2), pp. 266-272. (doi:10.1002/cmdc.201000343)

Tran, A.T., Cergol, K.M., West, N.P., Randall, E.J., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J., and Payne, R.J. (2011) Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem, 6(2), pp. 262-265. (doi:10.1002/cmdc.201000399)

Hendry, E., Carpy, T., Johnston, J., Popland, M., Mikhaylovskiy, R.V., Lapthorn, A., Kelly, S.M., Barron, L.D., Gadegaard, N., and Kadodwala, M. (2010) Ultrasensitive detection and characterization of biomolecules using superchiral fields. Nature Nanotechnology, 5(11), pp. 783-787. (doi:10.1038/nnano.2010.209)

Tran, A.T., Cergol, K.M., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J., and Payne, R.J. (2010) Rapid assembly of potent type II dehydroquinase inhibitors via "Click" chemistry. MedChemComm, 1(4), pp. 271-275. (doi:10.1039/c0md00097c)

Dixon, D. P., Lapthorn, A., Madesis, P., Mudd, E. A., Day, A., and Edwards, R. (2008) Binding and glutathione conjugation of porphyrinogens by plant glutathione transferases. Journal of Biological Chemistry, 283(29), pp. 20268-20276. (doi:10.1074/jbc.M802026200)

Stewart, K. A., Robinson, D. A., and Lapthorn, A. J. (2008) Type II dehydroquinase: molecular replacement with many copies. Acta Crystallographica. Section D: Biological Crystallography, 64, pp. 108-118. (doi:10.1107/S0907444907054923)

Payne, R.J., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A.D., Lapthorn, A.J., and Abell, C. (2007) Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases. ChemMedChem, 2(7), pp. 1010-1013. (doi:10.1002/cmdc.200700062)

Prazeres, V. F.V., Sanchez-Sixto, C., Castedo, L., Lamb, H., Hawkins, A. R., Riboldi-Tunnicliffe, A., Coggins, J. R., Lapthorn, A. J., and Gonzalez-Bello, C. (2007) Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase. ChemMedChem, 2(2), pp. 194-207. (doi:10.1002/cmdc.200600208)

Lohkamp, B., Paterson, N., and Lapthorn, A. (2006) Application of a new vector system for efficient protein purification in the crystallization of PA5104/ORF from Pseudomonas aeruginosa. Journal of Structural Biology, 155, pp. 111-113. (doi:10.1016/j.jsb.2006.03.016)

Robinson, D.A.,, Stewart, K.A., Price, N.C., Chalk, P.A., Coggins, J.R., and Lapthorn, A.J. (2006) Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design. Journal of Medicinal Chemistry, 49(4), pp. 1282-1290. (doi:10.1021/jm0505361)

Zhu, X., Lapthorn, A., and Ellis, E. (2006) Crystal structure of mouse succinic semialdehyde reductase AKR7A5: Structural basis for substrate specificity. Biochemistry, 45, pp. 1562-1570. (doi:10.1021/bi051610k)

Dias-Gunasekara, S., Gubbens, J., van Lith, M., Dunne, C., Williams, J.A.G., Kataky, R., Scoones, D., Lapthorn, A., Bulleid, N.J., and Benham, A.M. (2005) Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1β. Journal of Biological Chemistry, 280, pp. 33066-33075. (doi:10.1074/jbc.M505023200)

Charrel-Dennis, M. et al. (2005) The human chorionic gonadotropin-beta arginine(68) to glutamic acid substitution fixes the conformation of the C-terminal peptide. Molecular Endocrinology, 19, pp. 1803-1811. (doi:10.1210/me.2004-0109)

Dixon, D., Lapthorn, A., and Edwards, R. (2005) Synthesis and analysis of chimeric maize glutathione transferases. Plant Science, 168, pp. 873-881. (doi:10.1016/j.plantsci.2004.11.009)

Toscano, M.D., Stewart, K.A., Coggins, J.R., Lapthorn, A.J., and Abell, C. (2005) Rational design of new bifunctional inhibitors of type II dehydroquinase. Organic and Biomolecular Chemistry, 3, pp. 3102-3104. (doi:10.1039/B507156A)

Lohkamp, B., McDermott, G., Campbell, S.A., Coggins, J.R., and Lapthorn, A.J. (2004) The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition. Journal of Molecular Biology, 336(1), pp. 131-144. (doi:10.1016/j.jmb.2003.12.020)

Charrel-Dennis, M., Jackson, A., Lund, T., Lapthorn, A., Berger, P., Roitt, I., and Delves, P. (2004) The major hormone-specific discontinuous epitopes on human chorionic gonadotrophin. Journal of Molecular Endocrinology, 32, pp. 571-581.

Frederickson, M., Roszak, A. W., Coggins, J. R., Lapthorn, A. J., and Abell, C. (2004) (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases. Organic and Biomolecular Chemistry, 2(11), pp. 1592-1596. (doi:10.1039/B404535A)

Coggins, J.R., Abell, C., Evan, L.B., Frederickson, M., Robinson, D.A., Roszak, A.W., and Lapthorn, A.P. (2003) Experiences with the Shikimate-pathway enzymes as targets for rational drug design. Biochemical Society Transactions, 31(3), pp. 548-552.

Cerasoli, E., Kelly, S.M., Coggins, J.R., Lapthorn, A.J., Clarke, D.T., and Price, N.C. (2003) Effects of salts on the function and conformational stability of shikimate kinase. Biochimica et Biophysica Acta: Proteins and Proteomics, 1648(1-2), pp. 43-54. (doi:10.1016/S1570-9639(03)00110-9)

Michel, G., Roszak, A.W., Sauve, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M., and Lapthorn, A.J. (2003) Structures of Shikimate dehydrogenase AroE and its paralog YdiB: a common structural framework for different activities. Journal of Biological Chemistry, 278, pp. 19463-19472. (doi:10.1074/jbc.M300794200)

Dixon, D., McEwen, A., Lapthorn, A., and Edwards, R. (2003) Forced evolution of a herbicide detoxifying glutathione transferase. Journal of Biological Chemistry, 278, pp. 23930-23935. (doi:10.1074/jbc.M303620200)

Kozma, E., Brown, E., Ellis, E.M., and Lapthorn, A.J. (2003) The high resolution crystal structure of rat liver AKR7A1: understanding the substrate specificites of the AKR7 family. Chemico-Biological Interactions, 143, pp. 289-297.

Evans, L. D.B., Roszak, A. W., Noble, L. J., Robinson, D. A., Chalk, P. A., Matthews, J. L., Coggins, J. R., Price, N. C., and Lapthorn, A. J. (2002) Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions. FEBS Letters, 530(1-3), pp. 24-30. (doi:10.1016/S0014-5793(02)03346-X)

Roszak, A.W., Robinson, D.A., Krell, T., Hunter, I.S., Fredrickson, M., Abell, C., Coggins, J.R., and Lapthorn, A.J. (2002) The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. Structure, 10(4), pp. 493-503. (doi:10.1016/S0969-2126(02)00747-5)

Dixon, D. P., Lapthorn, A., and Edwards, R. (2002) Plant glutathione transferases. Genome Biology, 3(3), reviews300. (doi:10.1186/gb-2002-3-3-reviews3004) (PMID:11897031) (PMCID:PMC139027)

Kozma, E., Brown, E., Ellis, E., and Lapthorn, A. (2002) The crystal structure of rat liver AKR7A1 - A dimeric member of the aldo-keto reductase superfamily. Journal of Biological Chemistry, 277, pp. 16285-16293. (doi:10.1074/jbc.M110808200)

Thom, R., Cummins, I., Dixon, D., Edwards, R., Cole, D., and Lapthorn, A. (2002) Structure of a tau class glutathione S-transferase from wheat active in herbicide detoxification. Biochemistry, 41, pp. 7008-7020. (doi:10.1021/bi015964x)

Krell, T., Maclean, J., Boam, D.J., Cooper, A., Resmini, M., Brocklehurst, K., Kelly, S.M., Price, N.C., Lapthorn, A.J., and Coggins, J.R. (2001) Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine. Protein Science, 10(6), pp. 1137-1149. (doi:10.1110/ps.52501)

Thom, R., Dixon, D., Edwards, R., Cole, D., and Lapthorn, A. (2001) The structure of a zeta class glutathione S-transferase from Arabidopsis thaliana: Characterisation of a GST with novel active-site architecture and a putative role in tyrosine catabolism. Journal of Molecular Biology, 308, pp. 949-962. (doi:10.1006/jmbi.2001.4638)

Thom, R., Dixon, D., Edwards, R., Cole, D., and Lapthorn, A. (2001) Structure determination of zeta class glutathione transferase from Arabidopsis thaliana. Chemico-Biological Interactions, 133, pp. 53-54.

Maclean, J., Campbell, S. A., Pollock, K., Chackrewarthy, S., Coggins, J. R., and Lapthorn, A. J. (2000) Crystallization and preliminary X-ray analysis of shikimate dehydrogenase fromEscherichia coli. Acta Crystallographica Section D: Biological Crystallography, 56(4), pp. 512-515. (doi:10.1107/S0907444900002377)

Krell, T., Coggins, J. R., and Lapthorn, A. J. (1998) The three-dimensional structure of shikimate kinase. Journal of Molecular Biology, 278(5), pp. 983-997. (doi:10.1006/jmbi.1998.1755) (PMID:9600856)

Idziak, C., Price, N. C., Kelly, S. M., Krell, T., Boam, D. J., Lapthorn, A. J., and Coggins, J. R. (1997) 93 The interaction of shikimate kinase fromErwinia chrystanthemiwith substrates. Biochemical Society Transactions, 25(4), S627-S627. (doi:10.1042/bst025s627)

Krell, T., Coyle, J. E., Horsburgh, M. J., Coggins, J. R., and Lapthorn, A. J. (1997) Crystallization and preliminary X-ray crystallographic analysis of shikimate kinase fromErwinia chrysanthemi. Acta Crystallographica Section D: Biological Crystallography, 53(5), pp. 612-614. (doi:10.1107/S0907444997004319)

Berger, P. et al. (1996) Immunochemical mapping of gonadotropins. Molecular and Cellular Endocrinology, 125(1-2), pp. 33-43. (doi:10.1016/S0303-7207(96)03943-3)

Bhowmick, N., Huang, J., Puett, D., Isaacs, N.W., and Lapthorn, A.J. (1996) Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling. Molecular Endocrinology, 10(9), pp. 1147-1159. (doi:10.1210/mend.10.9.8885249)

Jackson, A. M., Klonisch, T., Lapthorn, A. J., Berger, P., Isaacs, N. W., Delves, P. J., Lund, T., and Roitt, I. M. (1996) Identification and selective destruction of shared epitopes in human chorionic gonadotropin beta subunit. Journal of Reproductive Immunology, 31(1-2), pp. 21-36. (doi:10.1016/0165-0378(96)00978-3)

Klonisch, T., Delves, P. J., Berger, P., Panayotou, G., Lapthorn, A. J., Isaacs, N. W., Wick, G., Lund, T., and Roitt, I. M. (1996) Relative location of epitopes involved in synergistic antibody binding using human chorionic gonadotropin as a model. European Journal of Immunology, 26(8), pp. 1897-1905. (doi:10.1002/eji.1830260834) (PMID:8765037)

Lapthorn, A.J., Janes, R. W., Isaacs, N.W., and Wallace, B.A. (1995) Cystine nooses and protein specificity. Nature Structural Biology, 2(4), pp. 266-268. (doi:10.1038/nsb0495-266) (PMID:7796259)

Lapthorn, A. J., Harris, D. C., Littlejohn, A., Lustbader, J. W., Canfield, R. E., Machin, K. J., Morgan, F. J., and Isaacs, N. W. (1994) Crystal structure of human chorionic gonadotropin. Nature, 369(6480), pp. 455-461. (doi:10.1038/369455a0) (PMID:8202136)

Guillet, V., Lapthorn, A., Hartley, R.W., and Mauguen, Y. (1993) Recognition between a bacterial ribonuclease, barnase, and its natural inhibitor, barstar. Structure, 1(3), pp. 165-176. (doi:10.1016/0969-2126(93)90018-C) (PMID:16100951)

Guillet, V., Lapthorn, A., and Mauguen, Y. (1993) Three-dimensional structure of a barnase-3'GMP complex at 2.2Å resolution. FEBS Letters, 330(2), pp. 137-140. (doi:10.1016/0014-5793(93)80259-W) (PMID:8396045)

Guillet, V., Lapthorn, A., Fourniat, J., Benoit, J.-P., Hartley, R. W., and Mauguen, Y. (1993) Crystallization and prelilminary X-ray investigation of barster, the intracellular inhibitor of barnase. Proteins, 17(3), pp. 325-328. (doi:10.1002/prot.340170309) (PMID:8272429)

This list was generated on Mon Apr 24 16:42:42 2017 BST.