Dr Adrian Lapthorn

Adrian Lapthorn
  • Senior Lecturer (Chemistry)

telephone: 01413305940
email: Adrian.Lapthorn@glasgow.ac.uk

Room B4-03
Chemistry
Joseph Black Building
Glasgow G12 8QQ


Research Interests

My research interests are in using the technique of protein crystallography to elucidate protein structure with an aim to answering important questions on protein function and mechanism. I also have a specific interest in protein-protein interactions. Protein Structure and Function; Enzymes of the Shikimate pathway; Structure aided drug discovery; Protein Crystallography; Plant Glutathione S-transferases.

More details are available on the personal Research Pages.

Research Topics

Protein Structure and Function
Enzymes of the Shikimate pathway
Structure aided drug discovery
Protein Crystallography
Plant Glutathione S-transferases

Publication Highlights

"Binding and glutathione conjugation of porphyrinogens by plant glutathione transferases". Dixon, D.P., Lapthorn, A.J., Madesis, P., Mudd, E.A., Day, A. and Edwards, R. J. Biol. Chem. 283, 20268-20276 (2008)

"Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases". Payne, R.J., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A.D., Lapthorn, A.J. and Abell, C. ChemMedChem, 2, 1010-1013 (2007)

"Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: New directions for inhibitor design". D.A. Robinson, K.A. Stewart, N.C. Price, P.A. Chalk, J.R. Coggins, A.J. Lapthorn, J. Med. Chem., 49, 1282-1290 (2006)

"Crystal structure of mouse succinic semialdehyde reductase AKR7A5: Structural basis for substrate specificity". X.F. Zhu, A.J. Lapthorn, E.M. Ellis, Biochemistry, 45, 1562-1570 (2006)

"The structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of substrate binding sites and mode of AMP inhibition". B. Lohkamp, G. McDermott, S.A. Campbell, J.R. Coggins, A.J. Lapthorn, J. Mol. Biol., 336, 131-144 (2004)

 

 

List all by: Type | Date

Jump to: 2014 | 2013 | 2011 | 2010 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 30.

2014

Turton, D. A., Senn, H., Harwood, T., Lapthorn, A. J., Ellis, E. M., and Wynne, K. (2014) Terahertz underdamped vibrational motion governs protein-ligand binding in solution. Nature Communications, 5 . p. 3999. ISSN 2041-1723 (doi:10.1038/ncomms4999)

2013

Turton, D., Harwood, T., Lapthorn, A., Ellis, E., and Wynne, K. (2013) Ultrabroadband terahertz spectroscopies of biomolecules and water. Proceedings of SPIE, 8623 (862303). ISSN 0277-786X (doi:10.1117/12.2003796)

2011

Paz, S. et al. (2011) Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase. ChemMedChem, 6 (2). pp. 266-272. ISSN 1860-7179 (doi:10.1002/cmdc.201000343)

Tran, A.T., Cergol, K.M. , West, N.P. , Randall, E.J. , Britton, W.J. , Bokhari, S.A.I. , Ibrahim, M. , Lapthorn, A.J., and Payne, R.J. (2011) Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem, 6 (2). pp. 262-265. ISSN 1860-7179 (doi:10.1002/cmdc.201000399)

2010

Hendry, E., Carpy, T., Johnston, J., Popland, M., Mikhaylovskiy, R.V., Lapthorn, A., Kelly, S.M., Barron, L.D., Gadegaard, N., and Kadodwala, M. (2010) Ultrasensitive detection and characterization of biomolecules using superchiral fields. Nature Nanotechnology, 5 (11). pp. 783-787. ISSN 1748-3387 (doi:10.1038/nnano.2010.209 )

Tran, A.T., Cergol, K.M., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J., and Payne, R.J. (2010) Rapid assembly of potent type II dehydroquinase inhibitors via "Click" chemistry. MedChemComm, 1 (4). pp. 271-275. ISSN 2040-2503 (doi:10.1039/c0md00097c )

2008

Dixon, D. P., Lapthorn, A., Madesis, P., Mudd, E. A., Day, A., and Edwards, R. (2008) Binding and glutathione conjugation of porphyrinogens by plant glutathione transferases. Journal of Biological Chemistry, 283 (29). pp. 20268-20276. ISSN 0021-9258 (doi:10.1074/jbc.M802026200 )

Stewart, K. A., Robinson, D. A., and Lapthorn, A. J. (2008) Type II dehydroquinase: molecular replacement with many copies. Acta Crystallographica. Section D: Biological Crystallography, 64 . pp. 108-118. ISSN 0907-4449 (doi:10.1107/S0907444907054923 )

2007

Payne, R.J., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A.D., Lapthorn, A.J., and Abell, C. (2007) Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases. ChemMedChem, 2 (7). pp. 1010-1013. ISSN 1860-7187 (doi:10.1002/cmdc.200700062)

2006

Lohkamp, B., Paterson, N., and Lapthorn, A. (2006) Application of a new vector system for efficient protein purification in the crystallization of PA5104/ORF from Pseudomonas aeruginosa. Journal of Structural Biology, 155 . pp. 111-113. (doi:10.1016/j.jsb.2006.03.016)

Robinson, D.A.,, Stewart, K.A., Price, N.C., Chalk, P.A., Coggins, J.R., and Lapthorn, A.J. (2006) Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design. Journal of Medicinal Chemistry, 49 (4). pp. 1282-1290. ISSN 0022-2623 (doi:10.1021/jm0505361)

Zhu, X., Lapthorn, A., and Ellis, E. (2006) Crystal structure of mouse succinic semialdehyde reductase AKR7A5: Structural basis for substrate specificity. Biochemistry, 45 . pp. 1562-1570. (doi:10.1021/bi051610k)

2005

Dias-Gunasekara, S., Gubbens, J., van Lith, M., Dunne, C., Williams, J.A.G., Kataky, R., Scoones, D., Lapthorn, A., Bulleid, N.J., and Benham, A.M. (2005) Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1β. Journal of Biological Chemistry, 280 . pp. 33066-33075. ISSN 0021-9258 (doi:10.1074/jbc.M505023200)

Charrel-Dennis, M. et al. (2005) The human chorionic gonadotropin-beta arginine(68) to glutamic acid substitution fixes the conformation of the C-terminal peptide. Molecular Endocrinology, 19 . pp. 1803-1811. (doi:10.1210/me.2004-0109)

Dixon, D., Lapthorn, A., and Edwards, R. (2005) Synthesis and analysis of chimeric maize glutathione transferases. Plant Science, 168 . pp. 873-881. (doi:10.1016/j.plantsci.2004.11.009)

Toscano, M.D., Stewart, K.A., Coggins, J.R., Lapthorn, A.J., and Abell, C. (2005) Rational design of new bifunctional inhibitors of type II dehydroquinase. Organic and Biomolecular Chemistry, 3 . pp. 3102-3104. ISSN 1477-0520 (doi:10.1039/B507156A)

2004

Lohkamp, B., McDermott, G., Campbell, S.A., Coggins, J.R., and Lapthorn, A.J. (2004) The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition. Journal of Molecular Biology, 336 (1). pp. 131-144. ISSN 0022-2836 (doi:10.1016/j.jmb.2003.12.020)

Charrel-Dennis, M., Jackson, A., Lund, T., Lapthorn, A., Berger, P., Roitt, I., and Delves, P. (2004) The major hormone-specific discontinuous epitopes on human chorionic gonadotrophin. Journal of Molecular Endocrinology, 32 . pp. 571-581.

2003

Coggins, J.R., Abell, C., Evan, L.B., Frederickson, M., Robinson, D.A., Roszak, A.W., and Lapthorn, A.P. (2003) Experiences with the Shikimate-pathway enzymes as targets for rational drug design. Biochemical Society Transactions, 31 (3). pp. 548-552. ISSN 0300-5127

Cerasoli, E., Kelly, S.M., Coggins, J.R., Lapthorn, A.J., Clarke, D.T., and Price, N.C. (2003) Effects of salts on the function and conformational stability of shikimate kinase. Biochimica et Biophysica Acta: Proteins and Proteomics, 1648 (1-2). pp. 43-54. ISSN 1570-9639 (doi:10.1016/S1570-9639(03)00110-9)

Michel, G., Roszak, A.W., Sauve, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M., and Lapthorn, A.J. (2003) Structures of Shikimate dehydrogenase AroE and its paralog YdiB: a common structural framework for different activities. Journal of Biological Chemistry, 278 . pp. 19463-19472. ISSN 0021-9258 (doi:10.1074/jbc.M300794200)

Dixon, D., McEwen, A., Lapthorn, A., and Edwards, R. (2003) Forced evolution of a herbicide detoxifying glutathione transferase. Journal of Biological Chemistry, 278 . pp. 23930-23935. ISSN 0021-9258 (doi:10.1074/jbc.M303620200)

Kozma, E., Brown, E., Ellis, E.M., and Lapthorn, A.J. (2003) The high resolution crystal structure of rat liver AKR7A1: understanding the substrate specificites of the AKR7 family. Chemico-Biological Interactions, 143 . pp. 289-297.

2002

Evans, L. D.B., Roszak, A. W., Noble, L. J., Robinson, D. A., Chalk, P. A., Matthews, J. L., Coggins, J. R., Price, N. C., and Lapthorn, A. J. (2002) Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions. FEBS Letters, 530 (1-3). pp. 24-30. ISSN 0014-5793 (doi:10.1016/S0014-5793(02)03346-X)

Roszak, A.W., Robinson, D.A., Krell, T., Hunter, I.S., Fredrickson, M., Abell, C., Coggins, J.R., and Lapthorn, A.J. (2002) The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. Structure, 10 (4). pp. 493-503. ISSN 0969-2126 (doi:10.1016/S0969-2126(02)00747-5)

Kozma, E., Brown, E., Ellis, E., and Lapthorn, A. (2002) The crystal structure of rat liver AKR7A1 - A dimeric member of the aldo-keto reductase superfamily. Journal of Biological Chemistry, 277 . pp. 16285-16293. ISSN 0021-9258 (doi:10.1074/jbc.M110808200)

Thom, R., Cummins, I., Dixon, D., Edwards, R., Cole, D., and Lapthorn, A. (2002) Structure of a tau class glutathione S-transferase from wheat active in herbicide detoxification. Biochemistry, 41 . pp. 7008-7020. (doi:10.1021/bi015964x)

2001

Krell, T., Maclean, J., Boam, D.J., Cooper, A., Resmini, M., Brocklehurst, K., Kelly, S.M., Price, N.C., Lapthorn, A.J., and Coggins, J.R. (2001) Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine. Protein Science, 10 (6). pp. 1137-1149. ISSN 0961-8368 (doi:10.1110/ps.52501)

Thom, R., Dixon, D., Edwards, R., Cole, D., and Lapthorn, A. (2001) The structure of a zeta class glutathione S-transferase from Arabidopsis thaliana: Characterisation of a GST with novel active-site architecture and a putative role in tyrosine catabolism. Journal of Molecular Biology, 308 . pp. 949-962. ISSN 0022-2836 (doi:10.1006/jmbi.2001.4638)

Thom, R., Dixon, D., Edwards, R., Cole, D., and Lapthorn, A. (2001) Structure determination of zeta class glutathione transferase from Arabidopsis thaliana. Chemico-Biological Interactions, 133 . pp. 53-54.

This list was generated on Thu Nov 27 22:25:29 2014 GMT.
Jump to: Articles
Number of items: 30.

Articles

Turton, D. A., Senn, H., Harwood, T., Lapthorn, A. J., Ellis, E. M., and Wynne, K. (2014) Terahertz underdamped vibrational motion governs protein-ligand binding in solution. Nature Communications, 5 . p. 3999. ISSN 2041-1723 (doi:10.1038/ncomms4999)

Turton, D., Harwood, T., Lapthorn, A., Ellis, E., and Wynne, K. (2013) Ultrabroadband terahertz spectroscopies of biomolecules and water. Proceedings of SPIE, 8623 (862303). ISSN 0277-786X (doi:10.1117/12.2003796)

Paz, S. et al. (2011) Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase. ChemMedChem, 6 (2). pp. 266-272. ISSN 1860-7179 (doi:10.1002/cmdc.201000343)

Tran, A.T., Cergol, K.M. , West, N.P. , Randall, E.J. , Britton, W.J. , Bokhari, S.A.I. , Ibrahim, M. , Lapthorn, A.J., and Payne, R.J. (2011) Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem, 6 (2). pp. 262-265. ISSN 1860-7179 (doi:10.1002/cmdc.201000399)

Hendry, E., Carpy, T., Johnston, J., Popland, M., Mikhaylovskiy, R.V., Lapthorn, A., Kelly, S.M., Barron, L.D., Gadegaard, N., and Kadodwala, M. (2010) Ultrasensitive detection and characterization of biomolecules using superchiral fields. Nature Nanotechnology, 5 (11). pp. 783-787. ISSN 1748-3387 (doi:10.1038/nnano.2010.209 )

Tran, A.T., Cergol, K.M., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J., and Payne, R.J. (2010) Rapid assembly of potent type II dehydroquinase inhibitors via "Click" chemistry. MedChemComm, 1 (4). pp. 271-275. ISSN 2040-2503 (doi:10.1039/c0md00097c )

Dixon, D. P., Lapthorn, A., Madesis, P., Mudd, E. A., Day, A., and Edwards, R. (2008) Binding and glutathione conjugation of porphyrinogens by plant glutathione transferases. Journal of Biological Chemistry, 283 (29). pp. 20268-20276. ISSN 0021-9258 (doi:10.1074/jbc.M802026200 )

Stewart, K. A., Robinson, D. A., and Lapthorn, A. J. (2008) Type II dehydroquinase: molecular replacement with many copies. Acta Crystallographica. Section D: Biological Crystallography, 64 . pp. 108-118. ISSN 0907-4449 (doi:10.1107/S0907444907054923 )

Payne, R.J., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A.D., Lapthorn, A.J., and Abell, C. (2007) Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases. ChemMedChem, 2 (7). pp. 1010-1013. ISSN 1860-7187 (doi:10.1002/cmdc.200700062)

Lohkamp, B., Paterson, N., and Lapthorn, A. (2006) Application of a new vector system for efficient protein purification in the crystallization of PA5104/ORF from Pseudomonas aeruginosa. Journal of Structural Biology, 155 . pp. 111-113. (doi:10.1016/j.jsb.2006.03.016)

Robinson, D.A.,, Stewart, K.A., Price, N.C., Chalk, P.A., Coggins, J.R., and Lapthorn, A.J. (2006) Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design. Journal of Medicinal Chemistry, 49 (4). pp. 1282-1290. ISSN 0022-2623 (doi:10.1021/jm0505361)

Zhu, X., Lapthorn, A., and Ellis, E. (2006) Crystal structure of mouse succinic semialdehyde reductase AKR7A5: Structural basis for substrate specificity. Biochemistry, 45 . pp. 1562-1570. (doi:10.1021/bi051610k)

Dias-Gunasekara, S., Gubbens, J., van Lith, M., Dunne, C., Williams, J.A.G., Kataky, R., Scoones, D., Lapthorn, A., Bulleid, N.J., and Benham, A.M. (2005) Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1β. Journal of Biological Chemistry, 280 . pp. 33066-33075. ISSN 0021-9258 (doi:10.1074/jbc.M505023200)

Charrel-Dennis, M. et al. (2005) The human chorionic gonadotropin-beta arginine(68) to glutamic acid substitution fixes the conformation of the C-terminal peptide. Molecular Endocrinology, 19 . pp. 1803-1811. (doi:10.1210/me.2004-0109)

Dixon, D., Lapthorn, A., and Edwards, R. (2005) Synthesis and analysis of chimeric maize glutathione transferases. Plant Science, 168 . pp. 873-881. (doi:10.1016/j.plantsci.2004.11.009)

Toscano, M.D., Stewart, K.A., Coggins, J.R., Lapthorn, A.J., and Abell, C. (2005) Rational design of new bifunctional inhibitors of type II dehydroquinase. Organic and Biomolecular Chemistry, 3 . pp. 3102-3104. ISSN 1477-0520 (doi:10.1039/B507156A)

Lohkamp, B., McDermott, G., Campbell, S.A., Coggins, J.R., and Lapthorn, A.J. (2004) The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition. Journal of Molecular Biology, 336 (1). pp. 131-144. ISSN 0022-2836 (doi:10.1016/j.jmb.2003.12.020)

Charrel-Dennis, M., Jackson, A., Lund, T., Lapthorn, A., Berger, P., Roitt, I., and Delves, P. (2004) The major hormone-specific discontinuous epitopes on human chorionic gonadotrophin. Journal of Molecular Endocrinology, 32 . pp. 571-581.

Coggins, J.R., Abell, C., Evan, L.B., Frederickson, M., Robinson, D.A., Roszak, A.W., and Lapthorn, A.P. (2003) Experiences with the Shikimate-pathway enzymes as targets for rational drug design. Biochemical Society Transactions, 31 (3). pp. 548-552. ISSN 0300-5127

Cerasoli, E., Kelly, S.M., Coggins, J.R., Lapthorn, A.J., Clarke, D.T., and Price, N.C. (2003) Effects of salts on the function and conformational stability of shikimate kinase. Biochimica et Biophysica Acta: Proteins and Proteomics, 1648 (1-2). pp. 43-54. ISSN 1570-9639 (doi:10.1016/S1570-9639(03)00110-9)

Michel, G., Roszak, A.W., Sauve, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M., and Lapthorn, A.J. (2003) Structures of Shikimate dehydrogenase AroE and its paralog YdiB: a common structural framework for different activities. Journal of Biological Chemistry, 278 . pp. 19463-19472. ISSN 0021-9258 (doi:10.1074/jbc.M300794200)

Dixon, D., McEwen, A., Lapthorn, A., and Edwards, R. (2003) Forced evolution of a herbicide detoxifying glutathione transferase. Journal of Biological Chemistry, 278 . pp. 23930-23935. ISSN 0021-9258 (doi:10.1074/jbc.M303620200)

Kozma, E., Brown, E., Ellis, E.M., and Lapthorn, A.J. (2003) The high resolution crystal structure of rat liver AKR7A1: understanding the substrate specificites of the AKR7 family. Chemico-Biological Interactions, 143 . pp. 289-297.

Evans, L. D.B., Roszak, A. W., Noble, L. J., Robinson, D. A., Chalk, P. A., Matthews, J. L., Coggins, J. R., Price, N. C., and Lapthorn, A. J. (2002) Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions. FEBS Letters, 530 (1-3). pp. 24-30. ISSN 0014-5793 (doi:10.1016/S0014-5793(02)03346-X)

Roszak, A.W., Robinson, D.A., Krell, T., Hunter, I.S., Fredrickson, M., Abell, C., Coggins, J.R., and Lapthorn, A.J. (2002) The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. Structure, 10 (4). pp. 493-503. ISSN 0969-2126 (doi:10.1016/S0969-2126(02)00747-5)

Kozma, E., Brown, E., Ellis, E., and Lapthorn, A. (2002) The crystal structure of rat liver AKR7A1 - A dimeric member of the aldo-keto reductase superfamily. Journal of Biological Chemistry, 277 . pp. 16285-16293. ISSN 0021-9258 (doi:10.1074/jbc.M110808200)

Thom, R., Cummins, I., Dixon, D., Edwards, R., Cole, D., and Lapthorn, A. (2002) Structure of a tau class glutathione S-transferase from wheat active in herbicide detoxification. Biochemistry, 41 . pp. 7008-7020. (doi:10.1021/bi015964x)

Krell, T., Maclean, J., Boam, D.J., Cooper, A., Resmini, M., Brocklehurst, K., Kelly, S.M., Price, N.C., Lapthorn, A.J., and Coggins, J.R. (2001) Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine. Protein Science, 10 (6). pp. 1137-1149. ISSN 0961-8368 (doi:10.1110/ps.52501)

Thom, R., Dixon, D., Edwards, R., Cole, D., and Lapthorn, A. (2001) The structure of a zeta class glutathione S-transferase from Arabidopsis thaliana: Characterisation of a GST with novel active-site architecture and a putative role in tyrosine catabolism. Journal of Molecular Biology, 308 . pp. 949-962. ISSN 0022-2836 (doi:10.1006/jmbi.2001.4638)

Thom, R., Dixon, D., Edwards, R., Cole, D., and Lapthorn, A. (2001) Structure determination of zeta class glutathione transferase from Arabidopsis thaliana. Chemico-Biological Interactions, 133 . pp. 53-54.

This list was generated on Thu Nov 27 22:25:29 2014 GMT.

Teaching

Science Fundamentals:- Aqueous Solutions Science Fundamentals:- Reaction Kinetics
Level-1 Chemistry:- Attractions and Repulsions
Level-3 Chemistry:- Biophysical Chemistry

Awards

PhD (York)