Sutherland group on front cover

Sutherland group on front cover

Issued: Tue, 15 Nov 2011 14:08:00 GMT

The Sutherland group have reported the first total synthesis of the marine natural products, Clavaminol A, C and H that have previously been shown to be highly cytotoxic against lung, breast and gastric carcinoma. The key steps of the first route to these compounds involved an ether directed palladium(II)-catalysed Overman rearrangement to install the erythro configuration and a one-pot, tributyltin hydride-mediated reduction that allowed simultaneous formation of the side-chain and N-acetyl groups.

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