Professor I Mhairi Macrae

  • Professor of Neuroscience (Stroke and Brain Imaging)

telephone: 01413306978
email: Mhairi.Macrae@glasgow.ac.uk

Wellcome Surgical Institute (WSI) Building
R214 Level 2
University of Glasgow
Garscube Estate

Research interests

Mhairi Macrae is a neuroscientist with an undergraduate and post-graduate degree in Pharmacology from the University of Glasgow.

Her main research interest is in stroke and cerebral blood flow (CBF), studying ischaemic brain injury using  in vivo rodent models, imaging techniques including MRI and behavioural testing. 

She has expertise in the development of animal models of experimental stroke, in the measurement of CBF and ischaemic damage and in the assessment of neurological deficits and functional recovery. Her research has included studies of CBF, brain metabolism, cerebral autoregulation, oxidative stress, inflammation and stroke sensitivity genes.

She is Deputy Head of Stroke and Brain Imaging, with her group based in the neuroscience laboratories of the Wellcome Surgical Institute (WSI),  Garscube Estate.

 

She is also Co-Director of the University of Glasgow Glasgow Experimental MRI Centre, situated adjacent to WSI in Garscube Estate.

Research

Current research interests related to stroke include the ischaemic penumbra, inflammation, hyperglycaemia and metabolic syndrome,  stem cell therapy and the influence of ageing.

She has a particular interest in neuroprotection strategies in focal cerebral ischaemia which has included studies on glutamate antagonists, anti-oxidants and oestrogen.  Her research also  involves identification of mechanisms responsible for inducing brain damage during ischaemia and reperfusion, and those promoting brain repair and  functional recovery.

A more recent research focus has been the use of MRI in neuroscience research with a particular interest in brain imaging.

Cerebral Blood Flow and the Ischaemic Penumbra

Aims & techniques: Investigation of the ischaemic penumbra and characterisation of changes in CBF is carried out in a range of experimental stroke models using blood flow autoradiography, laser Doppler flowmetry and, more recently, MRI techniques.

Collaborators: Debbie Dewar, Chris McCabe and William Holmes and Keith Muir (Centre for Stroke and Brain Imaging), Barrie Condon and David Brennan (Clinical Physics), Celestine Santosh and Donald Hadley (Neuroradiology), Lorraine Work (Institute of Cardiovascular and Medical Sciences)

Oxidative Stress and Inflammation

Aims & techniques: The role of oxidative stress and inflammation in stroke is studied in normotensive and hypertensive (SHRSP) rat strains using immunohistochemistry and histology techniques to identify inflammatory cells and oxidative damage.

Collaborators: Anna Dominiczak and her group (Division of Cardiovascular and Medical Sciences), Hilary Carswell (Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde) and David I Graham (Division of Clinical Neuroscience).

 Oestrogen and Stroke

Aims & techniques: Brain aromatase and the influence of oestrogen and  oestrogenic drugs on stroke outcome are studied using blood flow techniques, histology & MRI assessment of infarct volume, immunohistochemistry and behavioural testing of sensorimotor function. 

Collaborators: Hilary Carswell (Strathclyde Institute of Pharmacy & Biomedical Sciences University of Strathclyde), Karen Horsburgh (Neuroscience, University of Edinburgh), Anna Dominiczak and her group (Division of Cardiovascular and Medical Sciences).

Experimental stroke studies in the spontaneously hypertensive stroke-prone  (SHRSP) rat

Techniques: Stroke sensitivity and recovery from stroke in the SHRSP are studied using blood flow techniques, MRI assessment of penumbra,  histology & MRI assessment of infarct volume, immunohistochemistry,  and behavioural testing of sensorimotor function.

Collaborators: Lorraine Work and Delyth Graham  (Institute of Cardiovascular and Medical Sciences), Debbie Dewar and Chris McCabe (Centre for Stroke and Brain Imaging).

Protein GADD34 and its role in Stroke

Aims & techniques: The role of protein GADD34 in brain ischaemia has been studied in rodents, including transgenic GADD34 knock-outs and in human post-mortem brain from stroke and cardiac arrest cases.  Histology & MRI are used for quantitation of infarct volume, immunohistochemistry to identify changes in GADD34 protein expression  and autoradiography to quantify protein synthesis inhibition in ischaemic brain.

Collaborators: Chris McCabe, David Graham (Division of Clinical Neuroscience), Hide Imai (Gunma University, Japan), S Moira Brown and June Harland (Crusade Laboratories).

White matter damage in Experimental Stroke

Aims & techniques: Rodent models of lacunar stroke and methodology to quantify white matter damage  have been developed to study the effects of ischaemia on white matter and the influence of drugs on white matter damage

Collaborators: Hide Imai (Gunma University, Japan), Keith Muir (Division of Clinical Neuroscience) Ken Lees (Division of Cardiovascular and Medical Sciences), Chris Weir (Roberson Centre for Biostatistics), Clotilde Lecrux and Omar Touzani (University of Caen, France)


Publications

List all by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 55.

2016

Muir, K. W. and Macrae, I. M. (2016) Neuroimaging as a selection tool and endpoint in preclinical and clinical trials. Translational Stroke Research, 7(5), pp. 368-377. (doi:10.1007/s12975-016-0487-1) (PMID:27543177)

Arumugam, T. V. et al. (2016) An atypical role for the myeloid receptor Mincle in central nervous system injury. Journal of Cerebral Blood Flow and Metabolism, (doi:10.1177/0271678X16661201) (PMID:27492949) (Early Online Publication)

2015

Murtha, L. A., McLeod, D. D., Pepperall, D., McCann, S. K., Beard, D. J., Tomkins, A. J., Holmes, W. M., McCabe, C. , Macrae, I. M. and Spratt, N. J. (2015) Intracranial pressure elevation after ischemic stroke in rats: cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy. Journal of Cerebral Blood Flow and Metabolism, 35, pp. 592-600. (doi:10.1038/jcbfm.2014.230) (PMID:25515213)

Baskerville, T. A., Macrae, I. M., Holmes, W. M. and McCabe, C. (2015) The influence of gender on ‘tissue at risk’ in acute stroke: A diffusion-weighted magnetic resonance imaging study in a rat model of focal cerebral ischaemia. Journal of Cerebral Blood Flow and Metabolism, 36(2), pp. 381-386. (doi:10.1177/0271678X15606137) (PMID:26661149)

2014

Rodie, M., Welsh, M., Holmes, W., Wudy, S., Hartmann, M., Macrae, I. M. and Ahmed, S. F. (2014) Early Androgen Blockade Influences Longer-Term Brain Metabolism As Assessed By Magnetic Resonance Spectroscopy. In: Endocrine Society's 96th Annual Meeting and Expo, Chicago, IL, USA, 21-24 Jun 2014,

Campbell, B. C. V. and Macrae, I. M. (2014) Translational perspectives on perfusion-diffusion mismatch in ischemic stroke. International Journal of Stroke, 10(2), pp. 153-162. (doi:10.1111/ijs.12186)

Robertson, C. A., McCabe, C. , Lopez-Gonzalez, M. R., Deuchar, G. A., Dani, K., Holmes, W. M., Muir, K. W., Santosh, C. and Macrae, I. M. (2014) Detection of ischemic penumbra using combined perfusion and T2* oxygen challenge imaging. International Journal of Stroke, 10(1), pp. 42-50. (doi:10.1111/ijs.12327)

Wetterling, F., Gallagher, L., Mullin, J., Holmes, W. M., McCabe, C. , Macrae, I. M. and Fagan, A. J. (2014) Sodium-23 magnetic resonance imaging has potential for improving penumbra detection but not for estimating stroke onset time. Journal of Cerebral Blood Flow and Metabolism, 35(1), pp. 103-110. (doi:10.1038/jcbfm.2014.174)

2013

Baron, J.-C., Macrae, I.M., Adams, H.P. and Dirnagl, U. (2013) ESC-BRAIN: experimental and clinical stroke research - do they connect? Cerebrovascular Diseases, 36(4), pp. 306-321. (doi:10.1159/000355027)

Ord, E. N.J. , Shirley, R., McClure, J. D., McCabe, C. , Kremer, E. J., Macrae, I. M. and Work, L. M. (2013) Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats. Journal of Cerebral Blood Flow and Metabolism, 33(8), pp. 1215-1224. (doi:10.1038/jcbfm.2013.70)

Brittain, J.F. et al. (2013) An MRI-histological study of white matter in stroke-free SHRSP. Journal of Cerebral Blood Flow and Metabolism, 33(5), pp. 760-763. (doi:10.1038/jcbfm.2013.14)

Deuchar, G.A., Brennan, D., Griffiths, H., Macrae, I.M. and Santosh, C. (2013) Perfluorocarbons enhance a T2*-based MRI technique for identifying the penumbra in a rat model of acute ischemic stroke. Journal of Cerebral Blood Flow and Metabolism, 33(9), pp. 1422-1428. (doi:10.1038/jcbfm.2013.86)

Tarr, D., Graham, D., Roy, L.A., Holmes, W.M., McCabe, C. , Macrae, I.M., Muir, K.W. and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33(10), pp. 1556-1563. (doi:10.1038/jcbfm.2013.107)

2012

Ord, E. N.J. , Shirley, R., van Kralingen, J. C., Graves, A., McClure, J. D., Wilkinson, M., McCabe, C. , Macrae, I. M. and Work, L. M. (2012) Positive impact of pre-stroke surgery on survival following transient focal ischemia in hypertensive rats. Journal of Neuroscience Methods, 211(2), pp. 305-308. (doi:10.1016/j.jneumeth.2012.09.001)

Reid, E., Graham, D., Lopez-Gonzalez, M. R., Holmes, W. M., Macrae, I. M. and McCabe, C. (2012) Penumbra detection using PWI/DWI mismatch MRI in a rat stroke model with and without comorbidity: comparison of methods. Journal of Cerebral Blood Flow and Metabolism, 32(9), pp. 1765-1777. (doi:10.1038/jcbfm.2012.69) (PMID:22669479) (PMCID:PMC3434632)

Baskerville, T., McCabe, C., Weir, C.J., Macrae, I.M. and Holmes, W. (2012) Noninvasive MRI measurement of CBF: evaluating an arterial spin labelling sequence with 99mTc- HMPAO CBF autoradiography in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism, 32(6), pp. 973-977. (doi:10.1038/jcbfm.2012.19) (PMID:22472604) (PMCID:PMC3367221)

Wetterling, F., Hogler, M., Molkenthin, U., Junge, S., Gallagher, L., Macrae, I.M. and Fagan, A.J. (2012) The design of a double-tuned two-port surface resonator and its application to in vivo Hydrogen- and Sodium-MRI. Journal of Magnetic Resonance, 217, pp. 10-18.

Bingham, D., Martin, S.J., Macrae, I.M. and Carswell, H.V.O. (2012) Watermaze performance after middle cerebral artery occlusion in the rat: the role of sensorimotor versus memory impairments. Journal of Cerebral Blood Flow and Metabolism, 32, pp. 989-999. (doi:10.1038/jcbfm.2012.16)

Holmes, W.M., Lopez-Gonzalez, M.R., Gallagher, L., Deuchar, G., Macrae, I. and Santosh, C. (2012) Novel MRI detection of the ischemic penumbra: direct assessment of metabolic integrity. NMR in Biomedicine, 25(2), pp. 295-304. (doi:10.1002/nbm.1748)

Wetterling, F., Gallagher, L., Macrae, I.M., Junge, S. and Fagan, A.J. (2012) Regional and temporal variations in tissue sodium concentration during the acute stroke phase. Magnetic Resonance in Medicine, 67(3), pp. 740-749. (doi:10.1002/mrm.23031)

2011

Macrae, I.M. (2011) Preclinical stroke research - advantages and disadvantages of the most common rodent models of focal ischaemia. British Journal of Pharmacology, 164(4), pp. 1062-1078. (doi:10.1111/j.1476-5381.2011.01398.x)

Baskerville, T., Deuchar, G. A., McCabe, C. , Robertson, C. A., Holmes, W. M., Santosh, C. and Macrae, I. M. (2011) Influence of 100% and 40% oxygen on penumbral blood flow, oxygen level, and T2*-weighted MRI in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism, 31(8), pp. 1799-1806. (doi:10.1038/jcbfm.2011.65)

Robertson, C. A., McCabe, C. , Gallagher, L., Lopez Gonzalez, M. d., Holmes, W. M., Condon, B., Muir, K. W., Santosh, C. and Macrae, I. M. (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion. Journal of Cerebral Blood Flow and Metabolism, 31(8), pp. 1788-1798. (doi:10.1038/jcbfm.2011.67)

Robertson, C. A., McCabe, C. , Gallagher, L., Lopez-Gonzalez, M. d., Holmes, W. M., Condon, B., Muir, K. W., Santosh, C. and Macrae, I. M. (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography. Journal of Cerebral Blood Flow and Metabolism, 31, pp. 1778-1787. (doi:10.1038/jcbfm.2011.66)

2010

Dani, K. A., Santosh, C., Brennan, D., McCabe, C. , Holmes, W. M., Condon, B., Hadley, D. M., Macrae, I. M., Shaw, M. and Muir, K. W. (2010) T2*-weighted magnetic resonance imaging with hyperoxia in acute ischemic stroke. Annals of Neurology, 68(1), pp. 37-47. (doi:10.1002/ana.22032)

Carswell, H.V.O., Macrae, I. M. and Farr, T.D. (2010) Complexities of oestrogen in stroke. Clinical Science, 118(5-6), pp. 375-389. (doi:10.1042/CS20090018)

McCabe, C. , Gallagher, L., Macrae, I.M., Gsell, W., Graham, D. and Dominiczak, A.F. (2010) Response to letter by Yao (Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats). Stroke, 41(4), E198-E199. (doi:10.1161/STROKEAHA.109.575704)

Wetterling, F., Tabbert, M., Junge, S., Gallagher, L., Macrae, I.M. and Fagan, A.J. (2010) A double-tuned1H/23Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRI. Physics in Medicine and Biology, 55(24), pp. 7681-7695. (doi:10.1088/0031-9155/55/24/019)

2009

McCabe, C., Gallagher, L., Gsell, W., Graham, D., Dominiczak, A. F. and Macrae, I. M. (2009) Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Stroke, 40(12), pp. 3864-3868. (doi:10.1161/STROKEAHA.109.559021)

Shah, I., Macrae, I. and Di Napoli, M. (2009) Neuroinflammation and Neuroprotective Strategies in Acute Ischaemic Stroke - from bench to bedside. Current Molecular Medicine, 9(3), pp. 336-354.

2008

Santosh, C. et al. (2008) Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra. Journal of Cerebral Blood Flow and Metabolism, 28(10), pp. 1742-1753. (doi:10.1038/jcbfm.2008.56)

McCabe, C. , White, F., Brown, S.M. and Macrae, I.M. (2008) GADD34 gene restores virulence in viral vector used in experimental stroke study. Journal of Cerebral Blood Flow and Metabolism, 28(4), pp. 747-751. (doi:10.1038/sj.jcbfm.9600565)

Lecrux, C., McCabe, C. , Weir, C.J., Gallagher, L., Mullin, J., Touzani, O., Muir, K., Lees, K.R. and Macrae, I.M. (2008) Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats. Stroke, 39(2), pp. 448-454. (doi:10.1161/STROKEAHA.107.492934)

Fagan, A., Mullin, J., Gallagher, L., Hadley, D., Macrae, I. and Condon, B. (2008) Serial postmortem relaxometry in the normal rat brain and following stroke. Journal of Magnetic Resonance Imaging, 27(3), pp. 469-475.

Farr, T., Carswell, H., Mccann, D., Sato, M., Bryant, H., Dodge, J. and Macrae, I. (2008) The selective oestrogen receptor modulator, LY362321, is not neuroprotective in a rat model of transient focal ischaemia. Journal of Neuroendocrinology, 20(3), pp. 366-374.

2007

Farr, T., Carswell, H., Gsell, W. and Macrae, I. (2007) Estrogen receptor beta agonist diarylpropiolnitrile (DPN) does not mediate neuroprotection in a rat model of permanent focal ischemia. Brain Research, 1185, pp. 275-282.

2006

Morton, E., Macrae, I.M., McCabe, C. , Brown, S.M. and White, F. (2006) Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia. International Journal of Cardiology, 107(1), pp. 126-129. (doi:10.1016/j.ijcard.2005.01.051)

Farr, T., Carswell, H., Gallagher, L., Condon, B., Fagan, A., Mullin, J. and Macrae, I. (2006) 17 beta-estradiol treatment following permanent focal ischemia does not influence recovery of sensorimotor function. Neurobiology of Disease, 23, pp. 552-562. (doi:10.1016/j.nbd.2006.04.009)

Macrae, I. and Carswell, H. (2006) Oestrogen and stroke: the potential for harm as well as benefit. Biochemical Society Transactions, 34, pp. 1362-1365.

2005

Bingham, D., Macrae, I. and Carswell, H. (2005) Detrimental effects of 17 beta-oestradiol after permanent middle cerebral artery occlusion. Journal of Cerebral Blood Flow and Metabolism, 25, pp. 414-420. (doi:10.1038/sj.jcbfm.9600031)

Brown, S., Gallagher, L., Graham, D., Harland, J., Imai, H., Macrae, I. and McCaig, D. (2005) Evolution of GADD34 expression after focal cerebral ischaemia. Brain Research, 1034, pp. 51-61. (doi:10.1016/j.brainres.2004.11.058)

Carswell, H., Dominiczak, A., Garcia-Segura, L., Harada, N., Hutchison, J. and Macrae, I. (2005) Brain aromatase expression after experimental stroke: Topography and time course. Journal of Steroid Biochemistry and Molecular Biology, 96(1), pp. 89-91. (doi:10.1016/j.jsbmb.2005.02.016)

Gordon, K., Macrae, I. and Carswell, H. (2005) Effects of 17 beta-oestradiol on cerebral ischaemic damage and lipid peroxidation. Brain Research, 1036, pp. 155-162. (doi:10.1016/j.brainres.2004.12.052)

McGill, J.K., Gallagher, L., Carswell, H.V.O., Irving, E.A., Dominiczak, A.F. and Macrae, I.M. (2005) Impaired functional recovery after stroke in the stroke-prone spontaneously hypertensive rat. Stroke, 36(1), pp. 135-141. (doi:10.1161/01.STR.0000149629.32525.b7)

Nemoto, K. et al. (2005) No involvement of the nerve growth factor gene locus in hypertension in spontaneously hypertensive rats. Hypertension Research, 28(2), pp. 155-163. (doi:10.1291/hypres.28.155)

2004

Antier, D., Carswell, H., Brosnan, M., Hamilton, C., Macrae, I., Groves, S., Jardine, E., Reid, J. and Dominiczak, A. (2004) Increased levels of superoxide in brains from old female rats. Free Radical Research, 38(2), pp. 177-183. (doi:10.1080/10715760310001643294)

Brown, S., Graham, D., Harland, J., Macrae, I., McCaig, D. and White, F. (2004) Up-regulation of a growth arrest and DNA damage protein (GADD34) in the ischaemic human brain: implications for protein synthesis regulation and DNA repair. Neuropathology and Applied Neurobiology, 30, pp. 683-691. (doi:10.1111/j.1365-2990.2004.00584.x)

Carswell, H.V.O., Gallagher, L., Harrop, E., Horsburgh, K.J. and Macrae, I.M. (2004) Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia. American Journal of Physiology: Heart and Circulatory Physiology, 287, H1501-H1504. (doi:10.1152/ajpheart.00227.2004)

2003

Graham, D., Imai, H., Macrae, I. and Masayasu, H. (2003) Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia. Free Radical Biology and Medicine, 34, pp. 56-63.

2002

Brown, S., Graham, D., Harland, J., Imai, H., Macrae, I. and McCulloch, J. (2002) Specific expression of the cell cycle regulation proteins, GADD34 and PCNA, in the peri-infarct zone after focal cerebral ischaemia in the rat. European Journal of Neuroscience, 15, pp. 1929-1936. (doi:10.1046/j.1460-9568.2002.02025.x)

Graham, D., Imai, H., Macrae, I., Masayasu, H. and McCulloch, J. (2002) New method for the quantitative assessment of axonal damage in focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism, 22, pp. 1080-1089.

Horsburgh, K., Macrae, I. and Carswell, H. (2002) Estrogen is neuroprotective via an apolipoprotein E-dependent mechanism in a mouse model of global ischemia. Journal of Cerebral Blood Flow and Metabolism, 22, pp. 1189-1195.

McBride, M., Carswell, H., Graham, D., Carr, F., Charchar, F., Macrae, I. and Dominiczak, A. (2002) Genetic and gender determinants of cerebrovascular disease. Seminars in Nephrology, 22, pp. 127-134. (doi:10.1053/snep.2002.30213)

2001

Marks, L., Carswell, H., Peters, E., Graham, D., Patterson, J., Dominiczak, A. and Macrae, I. (2001) Characterization of the microglial response to cerebral ischemia in the stroke-prone spontaneously hypertensive rat. Hypertension, 38, pp. 116-122. (doi:10.1161/01.HYP.38.1.116)

Negrin, C., McBride, M., Carswell, H., Graham, D., Carr, F., Clark, J., Jeffs, B., Anderson, N., Macrae, I. and Dominiczak, A. (2001) Reciprocal consomic strains to evaluate Y chromosome effects. Hypertension, 37, pp. 391-397. (doi:10.1161/01.HYP.37.2.391)

This list was generated on Tue May 23 10:43:05 2017 BST.
Number of items: 55.

Articles

Muir, K. W. and Macrae, I. M. (2016) Neuroimaging as a selection tool and endpoint in preclinical and clinical trials. Translational Stroke Research, 7(5), pp. 368-377. (doi:10.1007/s12975-016-0487-1) (PMID:27543177)

Arumugam, T. V. et al. (2016) An atypical role for the myeloid receptor Mincle in central nervous system injury. Journal of Cerebral Blood Flow and Metabolism, (doi:10.1177/0271678X16661201) (PMID:27492949) (Early Online Publication)

Murtha, L. A., McLeod, D. D., Pepperall, D., McCann, S. K., Beard, D. J., Tomkins, A. J., Holmes, W. M., McCabe, C. , Macrae, I. M. and Spratt, N. J. (2015) Intracranial pressure elevation after ischemic stroke in rats: cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy. Journal of Cerebral Blood Flow and Metabolism, 35, pp. 592-600. (doi:10.1038/jcbfm.2014.230) (PMID:25515213)

Baskerville, T. A., Macrae, I. M., Holmes, W. M. and McCabe, C. (2015) The influence of gender on ‘tissue at risk’ in acute stroke: A diffusion-weighted magnetic resonance imaging study in a rat model of focal cerebral ischaemia. Journal of Cerebral Blood Flow and Metabolism, 36(2), pp. 381-386. (doi:10.1177/0271678X15606137) (PMID:26661149)

Campbell, B. C. V. and Macrae, I. M. (2014) Translational perspectives on perfusion-diffusion mismatch in ischemic stroke. International Journal of Stroke, 10(2), pp. 153-162. (doi:10.1111/ijs.12186)

Robertson, C. A., McCabe, C. , Lopez-Gonzalez, M. R., Deuchar, G. A., Dani, K., Holmes, W. M., Muir, K. W., Santosh, C. and Macrae, I. M. (2014) Detection of ischemic penumbra using combined perfusion and T2* oxygen challenge imaging. International Journal of Stroke, 10(1), pp. 42-50. (doi:10.1111/ijs.12327)

Wetterling, F., Gallagher, L., Mullin, J., Holmes, W. M., McCabe, C. , Macrae, I. M. and Fagan, A. J. (2014) Sodium-23 magnetic resonance imaging has potential for improving penumbra detection but not for estimating stroke onset time. Journal of Cerebral Blood Flow and Metabolism, 35(1), pp. 103-110. (doi:10.1038/jcbfm.2014.174)

Baron, J.-C., Macrae, I.M., Adams, H.P. and Dirnagl, U. (2013) ESC-BRAIN: experimental and clinical stroke research - do they connect? Cerebrovascular Diseases, 36(4), pp. 306-321. (doi:10.1159/000355027)

Ord, E. N.J. , Shirley, R., McClure, J. D., McCabe, C. , Kremer, E. J., Macrae, I. M. and Work, L. M. (2013) Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats. Journal of Cerebral Blood Flow and Metabolism, 33(8), pp. 1215-1224. (doi:10.1038/jcbfm.2013.70)

Brittain, J.F. et al. (2013) An MRI-histological study of white matter in stroke-free SHRSP. Journal of Cerebral Blood Flow and Metabolism, 33(5), pp. 760-763. (doi:10.1038/jcbfm.2013.14)

Deuchar, G.A., Brennan, D., Griffiths, H., Macrae, I.M. and Santosh, C. (2013) Perfluorocarbons enhance a T2*-based MRI technique for identifying the penumbra in a rat model of acute ischemic stroke. Journal of Cerebral Blood Flow and Metabolism, 33(9), pp. 1422-1428. (doi:10.1038/jcbfm.2013.86)

Tarr, D., Graham, D., Roy, L.A., Holmes, W.M., McCabe, C. , Macrae, I.M., Muir, K.W. and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33(10), pp. 1556-1563. (doi:10.1038/jcbfm.2013.107)

Ord, E. N.J. , Shirley, R., van Kralingen, J. C., Graves, A., McClure, J. D., Wilkinson, M., McCabe, C. , Macrae, I. M. and Work, L. M. (2012) Positive impact of pre-stroke surgery on survival following transient focal ischemia in hypertensive rats. Journal of Neuroscience Methods, 211(2), pp. 305-308. (doi:10.1016/j.jneumeth.2012.09.001)

Reid, E., Graham, D., Lopez-Gonzalez, M. R., Holmes, W. M., Macrae, I. M. and McCabe, C. (2012) Penumbra detection using PWI/DWI mismatch MRI in a rat stroke model with and without comorbidity: comparison of methods. Journal of Cerebral Blood Flow and Metabolism, 32(9), pp. 1765-1777. (doi:10.1038/jcbfm.2012.69) (PMID:22669479) (PMCID:PMC3434632)

Baskerville, T., McCabe, C., Weir, C.J., Macrae, I.M. and Holmes, W. (2012) Noninvasive MRI measurement of CBF: evaluating an arterial spin labelling sequence with 99mTc- HMPAO CBF autoradiography in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism, 32(6), pp. 973-977. (doi:10.1038/jcbfm.2012.19) (PMID:22472604) (PMCID:PMC3367221)

Wetterling, F., Hogler, M., Molkenthin, U., Junge, S., Gallagher, L., Macrae, I.M. and Fagan, A.J. (2012) The design of a double-tuned two-port surface resonator and its application to in vivo Hydrogen- and Sodium-MRI. Journal of Magnetic Resonance, 217, pp. 10-18.

Bingham, D., Martin, S.J., Macrae, I.M. and Carswell, H.V.O. (2012) Watermaze performance after middle cerebral artery occlusion in the rat: the role of sensorimotor versus memory impairments. Journal of Cerebral Blood Flow and Metabolism, 32, pp. 989-999. (doi:10.1038/jcbfm.2012.16)

Holmes, W.M., Lopez-Gonzalez, M.R., Gallagher, L., Deuchar, G., Macrae, I. and Santosh, C. (2012) Novel MRI detection of the ischemic penumbra: direct assessment of metabolic integrity. NMR in Biomedicine, 25(2), pp. 295-304. (doi:10.1002/nbm.1748)

Wetterling, F., Gallagher, L., Macrae, I.M., Junge, S. and Fagan, A.J. (2012) Regional and temporal variations in tissue sodium concentration during the acute stroke phase. Magnetic Resonance in Medicine, 67(3), pp. 740-749. (doi:10.1002/mrm.23031)

Macrae, I.M. (2011) Preclinical stroke research - advantages and disadvantages of the most common rodent models of focal ischaemia. British Journal of Pharmacology, 164(4), pp. 1062-1078. (doi:10.1111/j.1476-5381.2011.01398.x)

Baskerville, T., Deuchar, G. A., McCabe, C. , Robertson, C. A., Holmes, W. M., Santosh, C. and Macrae, I. M. (2011) Influence of 100% and 40% oxygen on penumbral blood flow, oxygen level, and T2*-weighted MRI in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism, 31(8), pp. 1799-1806. (doi:10.1038/jcbfm.2011.65)

Robertson, C. A., McCabe, C. , Gallagher, L., Lopez Gonzalez, M. d., Holmes, W. M., Condon, B., Muir, K. W., Santosh, C. and Macrae, I. M. (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion. Journal of Cerebral Blood Flow and Metabolism, 31(8), pp. 1788-1798. (doi:10.1038/jcbfm.2011.67)

Robertson, C. A., McCabe, C. , Gallagher, L., Lopez-Gonzalez, M. d., Holmes, W. M., Condon, B., Muir, K. W., Santosh, C. and Macrae, I. M. (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography. Journal of Cerebral Blood Flow and Metabolism, 31, pp. 1778-1787. (doi:10.1038/jcbfm.2011.66)

Dani, K. A., Santosh, C., Brennan, D., McCabe, C. , Holmes, W. M., Condon, B., Hadley, D. M., Macrae, I. M., Shaw, M. and Muir, K. W. (2010) T2*-weighted magnetic resonance imaging with hyperoxia in acute ischemic stroke. Annals of Neurology, 68(1), pp. 37-47. (doi:10.1002/ana.22032)

Carswell, H.V.O., Macrae, I. M. and Farr, T.D. (2010) Complexities of oestrogen in stroke. Clinical Science, 118(5-6), pp. 375-389. (doi:10.1042/CS20090018)

McCabe, C. , Gallagher, L., Macrae, I.M., Gsell, W., Graham, D. and Dominiczak, A.F. (2010) Response to letter by Yao (Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats). Stroke, 41(4), E198-E199. (doi:10.1161/STROKEAHA.109.575704)

Wetterling, F., Tabbert, M., Junge, S., Gallagher, L., Macrae, I.M. and Fagan, A.J. (2010) A double-tuned1H/23Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRI. Physics in Medicine and Biology, 55(24), pp. 7681-7695. (doi:10.1088/0031-9155/55/24/019)

McCabe, C., Gallagher, L., Gsell, W., Graham, D., Dominiczak, A. F. and Macrae, I. M. (2009) Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Stroke, 40(12), pp. 3864-3868. (doi:10.1161/STROKEAHA.109.559021)

Shah, I., Macrae, I. and Di Napoli, M. (2009) Neuroinflammation and Neuroprotective Strategies in Acute Ischaemic Stroke - from bench to bedside. Current Molecular Medicine, 9(3), pp. 336-354.

Santosh, C. et al. (2008) Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra. Journal of Cerebral Blood Flow and Metabolism, 28(10), pp. 1742-1753. (doi:10.1038/jcbfm.2008.56)

McCabe, C. , White, F., Brown, S.M. and Macrae, I.M. (2008) GADD34 gene restores virulence in viral vector used in experimental stroke study. Journal of Cerebral Blood Flow and Metabolism, 28(4), pp. 747-751. (doi:10.1038/sj.jcbfm.9600565)

Lecrux, C., McCabe, C. , Weir, C.J., Gallagher, L., Mullin, J., Touzani, O., Muir, K., Lees, K.R. and Macrae, I.M. (2008) Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats. Stroke, 39(2), pp. 448-454. (doi:10.1161/STROKEAHA.107.492934)

Fagan, A., Mullin, J., Gallagher, L., Hadley, D., Macrae, I. and Condon, B. (2008) Serial postmortem relaxometry in the normal rat brain and following stroke. Journal of Magnetic Resonance Imaging, 27(3), pp. 469-475.

Farr, T., Carswell, H., Mccann, D., Sato, M., Bryant, H., Dodge, J. and Macrae, I. (2008) The selective oestrogen receptor modulator, LY362321, is not neuroprotective in a rat model of transient focal ischaemia. Journal of Neuroendocrinology, 20(3), pp. 366-374.

Farr, T., Carswell, H., Gsell, W. and Macrae, I. (2007) Estrogen receptor beta agonist diarylpropiolnitrile (DPN) does not mediate neuroprotection in a rat model of permanent focal ischemia. Brain Research, 1185, pp. 275-282.

Morton, E., Macrae, I.M., McCabe, C. , Brown, S.M. and White, F. (2006) Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia. International Journal of Cardiology, 107(1), pp. 126-129. (doi:10.1016/j.ijcard.2005.01.051)

Farr, T., Carswell, H., Gallagher, L., Condon, B., Fagan, A., Mullin, J. and Macrae, I. (2006) 17 beta-estradiol treatment following permanent focal ischemia does not influence recovery of sensorimotor function. Neurobiology of Disease, 23, pp. 552-562. (doi:10.1016/j.nbd.2006.04.009)

Macrae, I. and Carswell, H. (2006) Oestrogen and stroke: the potential for harm as well as benefit. Biochemical Society Transactions, 34, pp. 1362-1365.

Bingham, D., Macrae, I. and Carswell, H. (2005) Detrimental effects of 17 beta-oestradiol after permanent middle cerebral artery occlusion. Journal of Cerebral Blood Flow and Metabolism, 25, pp. 414-420. (doi:10.1038/sj.jcbfm.9600031)

Brown, S., Gallagher, L., Graham, D., Harland, J., Imai, H., Macrae, I. and McCaig, D. (2005) Evolution of GADD34 expression after focal cerebral ischaemia. Brain Research, 1034, pp. 51-61. (doi:10.1016/j.brainres.2004.11.058)

Carswell, H., Dominiczak, A., Garcia-Segura, L., Harada, N., Hutchison, J. and Macrae, I. (2005) Brain aromatase expression after experimental stroke: Topography and time course. Journal of Steroid Biochemistry and Molecular Biology, 96(1), pp. 89-91. (doi:10.1016/j.jsbmb.2005.02.016)

Gordon, K., Macrae, I. and Carswell, H. (2005) Effects of 17 beta-oestradiol on cerebral ischaemic damage and lipid peroxidation. Brain Research, 1036, pp. 155-162. (doi:10.1016/j.brainres.2004.12.052)

McGill, J.K., Gallagher, L., Carswell, H.V.O., Irving, E.A., Dominiczak, A.F. and Macrae, I.M. (2005) Impaired functional recovery after stroke in the stroke-prone spontaneously hypertensive rat. Stroke, 36(1), pp. 135-141. (doi:10.1161/01.STR.0000149629.32525.b7)

Nemoto, K. et al. (2005) No involvement of the nerve growth factor gene locus in hypertension in spontaneously hypertensive rats. Hypertension Research, 28(2), pp. 155-163. (doi:10.1291/hypres.28.155)

Antier, D., Carswell, H., Brosnan, M., Hamilton, C., Macrae, I., Groves, S., Jardine, E., Reid, J. and Dominiczak, A. (2004) Increased levels of superoxide in brains from old female rats. Free Radical Research, 38(2), pp. 177-183. (doi:10.1080/10715760310001643294)

Brown, S., Graham, D., Harland, J., Macrae, I., McCaig, D. and White, F. (2004) Up-regulation of a growth arrest and DNA damage protein (GADD34) in the ischaemic human brain: implications for protein synthesis regulation and DNA repair. Neuropathology and Applied Neurobiology, 30, pp. 683-691. (doi:10.1111/j.1365-2990.2004.00584.x)

Carswell, H.V.O., Gallagher, L., Harrop, E., Horsburgh, K.J. and Macrae, I.M. (2004) Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia. American Journal of Physiology: Heart and Circulatory Physiology, 287, H1501-H1504. (doi:10.1152/ajpheart.00227.2004)

Graham, D., Imai, H., Macrae, I. and Masayasu, H. (2003) Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia. Free Radical Biology and Medicine, 34, pp. 56-63.

Brown, S., Graham, D., Harland, J., Imai, H., Macrae, I. and McCulloch, J. (2002) Specific expression of the cell cycle regulation proteins, GADD34 and PCNA, in the peri-infarct zone after focal cerebral ischaemia in the rat. European Journal of Neuroscience, 15, pp. 1929-1936. (doi:10.1046/j.1460-9568.2002.02025.x)

Graham, D., Imai, H., Macrae, I., Masayasu, H. and McCulloch, J. (2002) New method for the quantitative assessment of axonal damage in focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism, 22, pp. 1080-1089.

Horsburgh, K., Macrae, I. and Carswell, H. (2002) Estrogen is neuroprotective via an apolipoprotein E-dependent mechanism in a mouse model of global ischemia. Journal of Cerebral Blood Flow and Metabolism, 22, pp. 1189-1195.

McBride, M., Carswell, H., Graham, D., Carr, F., Charchar, F., Macrae, I. and Dominiczak, A. (2002) Genetic and gender determinants of cerebrovascular disease. Seminars in Nephrology, 22, pp. 127-134. (doi:10.1053/snep.2002.30213)

Marks, L., Carswell, H., Peters, E., Graham, D., Patterson, J., Dominiczak, A. and Macrae, I. (2001) Characterization of the microglial response to cerebral ischemia in the stroke-prone spontaneously hypertensive rat. Hypertension, 38, pp. 116-122. (doi:10.1161/01.HYP.38.1.116)

Negrin, C., McBride, M., Carswell, H., Graham, D., Carr, F., Clark, J., Jeffs, B., Anderson, N., Macrae, I. and Dominiczak, A. (2001) Reciprocal consomic strains to evaluate Y chromosome effects. Hypertension, 37, pp. 391-397. (doi:10.1161/01.HYP.37.2.391)

Conference Proceedings

Rodie, M., Welsh, M., Holmes, W., Wudy, S., Hartmann, M., Macrae, I. M. and Ahmed, S. F. (2014) Early Androgen Blockade Influences Longer-Term Brain Metabolism As Assessed By Magnetic Resonance Spectroscopy. In: Endocrine Society's 96th Annual Meeting and Expo, Chicago, IL, USA, 21-24 Jun 2014,

This list was generated on Tue May 23 10:43:05 2017 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Refinement in pre-clinical stroke research: investigation of morbidity and mortality and development of improved post-stroke care in rodents
    American College of Laboratory
    2015 - 2016
     
  • Angiotensin-(1-7): a novel treatment for acute and long term recovery from stroke?
    The Henry Smith Charity
    2014 - 2016
     
  • Development of a novel acute stroke theranostic (ISSF STS)
    Wellcome Trust
    2014 - 2015
     
  • Helping the brain help itself to recover after injury
    Rosetrees Trust
    2014 - 2015
     
  • Investigation of [18F]-Fluciclatide as a PET imaging agent for imaging angiogenesis in Glioblastoma
    Cancer Research UK
    2012 - 2013
     
  • Supporting the ischaemic brain with oxygen-carrying perfluorocarbons.
    Scottish Executive Health Department
    2012 - 2013
     
  • Supporting the ischaemic brain with oxygen-carrying perfluorocarbons.
    Scottish Executive Health Department
    2012 - 2014
     
  • Metabolic MRI in Acute Stroke; Development and Validation of the 'Oxygen Challenge' Technique
    Scottish Executive Health Department
    2012 - 2014
     
  • Sodium imaging following an "Oxygen Challenge" to assess function of the N/K ATP pump following ischaemia to demonstrate membrane integrity: A novel technique to identify the functional "Penumbra"?
    Neurosciences Foundation
    2011 - 2012
     
  • Development and application of oscillatory gradient spin echo in stroke animal model at 7T and further validation with histology
    Neurosciences Foundation
    2011 - 2012
     
  • SINAPSE-SPIRIT: Novel and collaborative approaches to knowledge exchange in translational imaging
    Scottish Funding Council
    2010 - 2013
     
  • Metabolic syndrome, hyperglycemia and experimental stroke
    Scottish Executive Health Department
    2009 - 2010
     
  • Development and Validation of an MRI Method to Image Cerebral Metabolism using Oxygen 17.
    Neurosciences Foundation
    2009 - 2009
     
  • Assessment of Myoglobin as a Novel MR Reporter Gene and its potential to protect Embryonic Stem Cells against hypoxia
    Neurosciences Foundation
    2009 - 2010
     
  • A combined approach targeting oxidative stress and apoptosis in stroke
    British Heart Foundation
    2008 - 2012
     
  • Developing a novel diagnostic imaging product for assessing metabolism and its application in stroke
    Scottish Enterprise
    2008 - 2010
     
  • Imaging the ischaemic penumbra using BOLD MRI with oxygen challenge as a biotracer
    MRC
    2008 - 2011
     
  • Stem cell research in experimental stroke
    British Council, India
    2008 - 2009
     
  • Brain'07 & BrainPET'07 the 23rd international symposium on cerebral blood flow, metabolism and quantification of brain function with PET
    Royal Society
    2007 - 2007
     
  • Characterising the ischaemic penumbra in the SIIRSP and WKY following focal cerebral ischaemia
    Neurosciences Foundation
    2006 - 2007
     
  • Neuroscience 2006
    Royal Society
    2006 - 2006
     
  • Targeted gene therapy for cardiovascular disease
    MRC
    2005 - 2008
     
  • Brain'05 & BrainPET'05 XXIInd International Symposium on Cerebral Blood Flow, Metabolism and Function
    Royal Society
    2005 - 2005
     
  • Can BOLD MRI imaging with an 02 challenge delineate the ischaemic penumbra in stroke?
    Neurosciences Foundation
    2005 - 2006
     
  • The role of GADD34 in cerebral ischaemia - an investigation of focal ischaemia in the GADD 34 knockout mouse
    Neurosciences Foundation
    2005 - 2007
     
  • Non-Invasive Imaging In Neuroscience: Small Bore High Field Magnetic Resonance Facility
    Scottish Higher Education Funding Council
    2002 - 2007