Dr Deborah Dewar

  • Senior Lecturer (Stroke and Brain Imaging)

telephone: 01413305828
email: Deborah.Dewar@glasgow.ac.uk

Wellcome Surgical Institute (WSI)
Institute of Neuroscience & Psychology
Garscube Estate
University of Glasgow

Research interests

Debbie Dewar is a neuroscientist with a B.Sc. in Biology & Psychology from Edinburgh University and a PhD from the Institute of Psychiatry, London. She has a long-standing interest in how brain chemistry and structure are altered after acute brain injury and in chronic brain disorders with a view to understanding pathogenic mechanisms and identifying targets for therapeutic intervention. Brain imaging at a variety of different levels, from tissue sections to whole brain is used in the majority of her research.

Developing novel treatments for reducing brain damage after a stroke is a major focus of current research. This work uses experimental models of cerebral ischaemia and insulin resistance in combination with various imaging techniques including, MRI, quantitative histology, immunohistochemistry and autoradiographic measurement of cerebral blood flow to understand how hyperglycaemia caused by either brain injury-induced stress or existing insulin resistance influences the extent of brain damage.

 

Figure shows MRI of rat brain slices following induction of focal cerebral ischaemia. The perfusion deficit is indicated in red and the diffusion lesion indicated in white. The mismatch between the two regions indicates the tissue that is “at risk” but may be protected from irreversible damage by intervention. Current work is aimed at determining if this area is compromised in the insulin resistant state. Images generated by PhD student David Tarr in collaboration with the Glasgow Experimental MRI Centre.

Previous research into neurotransmitter deficits in human postmortem brain from patients with Alzheimer’s disease or traumatic brain injury lead to current research developing novel molecular neuroimaging radiotracers for Single Photon Emission Tomography (SPECT). This work is done in collaboration with Sally Pimlott (NHS Radiopharmaceutical Research & Development) and Andy Sutherland (School of Chemistry). Current research is focussed on molecules that could be used to image the brain noradrenaline transporter or the translocator protein (as a biomarker of activated microglia after traumatic brain injury; collaboration with Willie Stewart, Department of Neuropathology, Institute of Neurological Sciences).


Publications

List all by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2003 | 2002 | 2001
Number of items: 41.

2016

Noor, K. M. K. M., Wyse, C., Roy, L. A., Biello, S. M., McCabe, C. and Dewar, D. (2016) Chronic photoperiod disruption does not increase vulnerability to focal cerebral ischemia in young normotensive rats. Journal of Cerebral Blood Flow and Metabolism, (doi:10.1177/0271678X16671316) (Early Online Publication)

Arumugam, T. V. et al. (2016) An atypical role for the myeloid receptor Mincle in central nervous system injury. Journal of Cerebral Blood Flow and Metabolism, (doi:10.1177/0271678X16661201) (PMID:27492949) (Early Online Publication)

Mitchell, E. J., Dewar, D. and Maxwell, D. J. (2016) Is remodelling of corticospinal tract terminations originating in the intact hemisphere associated with recovery following transient ischaemic stroke in the rat? PLoS ONE, 11(3), e0152176. (doi:10.1371/journal.pone.0152176) (PMID:27014870) (PMCID:PMC4807821)

Mitchell, E. J., McCallum, S., Dewar, D. and Maxwell, D. (2016) Corticospinal and reticulospinal contacts on cervical commissural and long descending propriospinal neurons in the adult rat spinal cord; evidence for powerful reticulospinal connections. PLoS ONE, 11(3), e0152094. (doi:10.1371/journal.pone.0152094) (PMID:26999665) (PMCID:PMC4801400)

2015

Blair, A., Zmuda, F., Malviya, G., Chalmers, A. J., Dewar, D., Pimlott, S. L. and Sutherland, A. (2015) A novel 18F-labelled high affinity agent for PET imaging of the translocator protein. Chemical Science, 6(8), pp. 4772-4777. (doi:10.1039/C5SC01647A)

2014

Hong, Y.T. et al. (2014) Amyloid imaging with carbon 11–labeled pittsburgh compound b for traumatic brain injury. JAMA Neurology, 71(1), pp. 23-31. (doi:10.1001/jamaneurol.2013.4847)

Lewis, D. Y., Champion, S. , Wyper, D., Dewar, D. and Pimlott, S. (2014) Assessment of [125I]WYE-230949 as a novel histamine H3 receptor radiopharmaceutical. PLoS ONE, 9(12), e115876. (doi:10.1371/journal.pone.0115876)

2013

Blair, A., Stevenson, L., Dewar, D., Pimlott, S.L. and Sutherland, A. (2013) Structure–activity relationships of novel iodinated quinoline-2-carboxamides for targeting the translocator protein. MedChemComm, 4(11), pp. 1461-1466. (doi:10.1039/c3md00249g)

Tarr, D., Graham, D., Roy, L.A., Holmes, W.M., McCabe, C. , Macrae, I.M., Muir, K.W. and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33(10), pp. 1556-1563. (doi:10.1038/jcbfm.2013.107)

2012

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., Pimlott, S.L., Batis, J., Barret, O., Seibyl, J. and Tamagnan, G. (2012) Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography. Synapse, 66(11), pp. 923-930. (doi:10.1002/syn.21585)

Tavares, A.A.S., Lewsey, J., Dewar, D. and Pimlott, S.L. (2012) Radiotracer properties determined by high performance liquid chromatography: a potential tool for brain radiotracer discovery. Nuclear Medicine and Biology, 39(1), pp. 127-135. (doi:10.1016/j.nucmedbio.2011.06.011)

2011

Ruest, T., Holmes, W.M., Barrie, J.A., Griffiths, I.R., Anderson, T.J. , Dewar, D. and Edgar, J.M. (2011) High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR in Biomedicine, 24(10), pp. 1369-1379. (doi:10.1002/nbm.1700)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A. and Pimlott, S.L. (2011) Development of the radiosynthesis of high-specific-activity 123I-NKJ64. Nuclear Medicine and Biology, 38(4), pp. 493-500. (doi:10.1016/j.nucmedbio.2010.11.011)

Moldrich, R.X. et al. (2011) Fgfr3 regulates development of the caudal telencephalon. Developmental Dynamics, 240(6), pp. 1586-1599. (doi:10.1002/dvdy.22636)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A. and Pimlott, S.L. (2011) 123I-NKJ64: A novel single photon emission computed tomography radiotracer for imaging the noradrenaline transporter in brain. Synapse, 65(7), pp. 658-667. (doi:10.1002/syn.20895)

2010

Tavares, A., Dewar, D., Sutherland, A. and Pimlott, S. (2010) (R,S)-2-Iodo-reboxetine: development as a novel SPECT radiotracer for imaging the noradrenaline transporter in brain. NeuroImage, 52(S1), S115-S115. (doi:10.1016/j.neuroimage.2010.04.094)

Cavanagh, J., Patterson, J., Pimlott, S.L., Wyper, D.J. and Dewar, D. (2010) SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the 42 nicotinic acetylcholine receptor [123I]5-I-A85380 ligand: in vivo and in vitro evidence. Synapse, 64(2), pp. 111-116. (doi:10.1002/syn.20705)

Lewis, D.Y., Champion, S., Dewar, D., Honey, G., Gross, J., Robichaud, A.J., Welch, A., Wyper, D. and Pimlott, S. (2010) Characterisation of novel histamine H3 receptor tracers for SPECT. Molecular Imaging and Biology, 12(S122), pp. 462-493.

Stevenson, L., Tavares, A.A.S., Brunet, A., McGonagle, F.I., Dewar, D., Pimlott, S.L. and Sutherland, A. (2010) New iodinated quinloine-2-varboxamides for SPECT imaging of the translocator protein. Bioorganic and Medicinal Chemistry Letters, 20(3), pp. 954-957. (doi:10.1016/j.bmcl.2009.12.061)

2009

Cain, S.M., Ruest, T., Pimlott, S.L., Patterson, J., Duncan, R.D., Dewar, D. and Sills, G.J. (2009) High resolution micro-SPECT scanning in rats using I-125 beta-CIT: Effects of chronic treatment with carbamazepine. Epilepsia, 50(8), pp. 1962-1970. (doi:10.1111/j.1528-1167.2009.02095.x)

Champion, S., Lewis, D., Dewar, D., Honey, G., Gross, J., Robichaud, A., Welch, A., Wyper, D. and Pimlott, S. (2009) Radiosynthesis and evaluation of novel histamine H3 tracers. Journal of Labelled Compounds and Radiopharmaceuticals, 52(S1), S381.

Jobson, N., Crawford, A., Dewar, D., Pimlott, S. and Sutherland, A. (2009) Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 19(17), pp. 4996-4998. (doi:10.1016/j.bmcl.2009.07.064)

Lewis, D., Champion, S., Dewar, D., Honey, G., Gross, J., Robichaud, A., Welch, A., Wyper, D. and Pimlott, S. (2009) Characterisation of Novel Histamine H3 receptor tracers for SPECT. Journal of Labelled Compounds and Radiopharmaceuticals, 52(S1), S381. (doi:10.1002/jlcr.1646)

2008

MacKenzie, S. M., Dewar, D., Stewart, W. , Fraser, R., Connell, J. M. C. and Davies, E. (2008) The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. Journal of Endocrinology, 196(1), pp. 123-130. (doi:10.1677/JOE-07-0427)

Jobson, N., Crawford, A., Dewar, D., Pimlott, S. and Sutherland, A. (2008) New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 18(18), pp. 4940-4943. (doi:10.1016/j.bmcl.2008.08.041)

Jobson, N., Spike, R., Crawford, A., Dewar, D., Pimlott, S. and Sutherland, A. (2008) Stereoselective synthesis of (2S,3R)- and (2R,3S)-iodoreboxetine; potential SPECT imaging agents for the noradrenaline transporter. Organic and Biomolecular Chemistry, 6(13), pp. 2369-2376. (doi:10.1039/b802819b)

2007

De Michele, M., Sette, G., Chalmers, D., Dewar, D., Toni, D., Sancesario, G. and McCulloch, J. (2007) Focal cerebral ischaemia induces corticotropin releasing factor (CRF) vascular immunoreactivity in rat occluded hemisphere. Regulatory Peptides, 143, pp. 69-75. (doi:10.1016/j.regpep.2007.03.004)

Dewar, D., Bentley, D. and Barnett, S. (2007) Implantation of pure cultured olfactory ensheathing cells in an animal model of parkinsonism. Acta Neurochirurgica, 149(4), pp. 407-414. (doi:10.1007/s00701-007-1121-5)

2006

Cavanagh, J., Patterson, J., Pimlott, S., Dewar, D., Eersels, J., Dempsey, M. and Wyper, D. (2006) Serotonin transporter residual availability during long-term antidepressant therapy does not differentiate responder and nonresponder unipolar patients. Biological Psychiatry, 59, pp. 301-308. (doi:10.1016/j.biopsych.2005.06.029)

Cuthill, D., Fowler, J., McCulloch, J. and Dewar, D. (2006) Different patterns of axonal damage after intracerebral injection of malonate or AMPA. Experimental Neurology, 200, pp. 509-520. (doi:10.1016/j.expneurol.2006.03.021)

Fowler, J., Edgar, J., Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I., Garbern, J., Nave, K. and Dewar, D. (2006) alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. Journal of Neuroscience Research, 84, pp. 68-77. (doi:10.1002/jnr.20859)

2005

Kennedy, L., Shelbourne, P. and Dewar, D. (2005) Alterations in dopamine and benzodiazepine receptor binding precede overt neuronal pathology in mice modelling early Huntington disease pathogenesis. Brain Research, 1039, pp. 14-21. (doi:10.1016/j.brainres.2005.01.029)

2003

Culpan, D., MacGowan, S.H., Ford, J.M., Nicoll, J.A.R., Griffin, W.S., Dewar, D., Cairns, N.J., Hughes, A., Kehoe, P.G. and Wilcock, G.K. (2003) Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease. Neuroscience Letters, 350(1), pp. 61-65. (doi:10.1016/S0304-3940(03)00854-1)

Dewar, D., Underhill, S. and Goldberg, T. (2003) Oligodendrocytes and ischemic brain injury. Journal of Cerebral Blood Flow and Metabolism, 23, pp. 263-274. (doi:10.1097/01.WCB.0000053472.41007.F9)

Fowler, J., McCracken, E., Dewar, D. and McCulloch, J. (2003) Intracerebral injection of AMPA causes axonal damage in vivo. Brain Research, 991, pp. 104-112. (doi:10.1016/j.brainres.2003.08.004)

McCracken, E., Dewar, D. and McCulloch, J. (2003) Sipatrigine and oligodendrocyte and axonal pathology following transient focal cerebral ischaemia in the rat. NeuroReport, 14, pp. 517-520. (doi:10.1097/01.wnr.0000059627.96928.1b)

2002

McCracken, E., Fowler, J., Dewar, D., Morrison, S. and McCulloch, J. (2002) Grey matter and white matter ischemic damage is reduced by the competitive AMPA receptor antagonist, SPD 502. Journal of Cerebral Blood Flow and Metabolism, 22, pp. 1090-1097.

Murdoch, I., Nicoll, J., Graham, D. and Dewar, D. (2002) Nucleus basalis of Meynert pathology in the human brain after fatal head injury. Journal of Neurotrauma, 19, pp. 279-284.

2001

Dewar, D. (2001) The absence of HLA-DRB1*03 is a risk factor in Alzheimer's disease. Alzheimer's Reports, 4, pp. 109-114.

Imai, H., Masayasu, H., Dewar, D., Graham, D. and Macrae, I. (2001) Ebselen protects both gray model of focal and white matter in a rodent cerebral ischemia. Stroke, 32, pp. 2149-2156.

McCracken, E., Dewar, D. and Hunter, A. (2001) White matter damage following systemic injection of the mitochondrial inhibitor 3-nitropropionic acid in rat. Brain Research, 892, pp. 329-335.

This list was generated on Mon May 22 06:54:12 2017 BST.
Jump to: Articles
Number of items: 41.

Articles

Noor, K. M. K. M., Wyse, C., Roy, L. A., Biello, S. M., McCabe, C. and Dewar, D. (2016) Chronic photoperiod disruption does not increase vulnerability to focal cerebral ischemia in young normotensive rats. Journal of Cerebral Blood Flow and Metabolism, (doi:10.1177/0271678X16671316) (Early Online Publication)

Arumugam, T. V. et al. (2016) An atypical role for the myeloid receptor Mincle in central nervous system injury. Journal of Cerebral Blood Flow and Metabolism, (doi:10.1177/0271678X16661201) (PMID:27492949) (Early Online Publication)

Mitchell, E. J., Dewar, D. and Maxwell, D. J. (2016) Is remodelling of corticospinal tract terminations originating in the intact hemisphere associated with recovery following transient ischaemic stroke in the rat? PLoS ONE, 11(3), e0152176. (doi:10.1371/journal.pone.0152176) (PMID:27014870) (PMCID:PMC4807821)

Mitchell, E. J., McCallum, S., Dewar, D. and Maxwell, D. (2016) Corticospinal and reticulospinal contacts on cervical commissural and long descending propriospinal neurons in the adult rat spinal cord; evidence for powerful reticulospinal connections. PLoS ONE, 11(3), e0152094. (doi:10.1371/journal.pone.0152094) (PMID:26999665) (PMCID:PMC4801400)

Blair, A., Zmuda, F., Malviya, G., Chalmers, A. J., Dewar, D., Pimlott, S. L. and Sutherland, A. (2015) A novel 18F-labelled high affinity agent for PET imaging of the translocator protein. Chemical Science, 6(8), pp. 4772-4777. (doi:10.1039/C5SC01647A)

Hong, Y.T. et al. (2014) Amyloid imaging with carbon 11–labeled pittsburgh compound b for traumatic brain injury. JAMA Neurology, 71(1), pp. 23-31. (doi:10.1001/jamaneurol.2013.4847)

Lewis, D. Y., Champion, S. , Wyper, D., Dewar, D. and Pimlott, S. (2014) Assessment of [125I]WYE-230949 as a novel histamine H3 receptor radiopharmaceutical. PLoS ONE, 9(12), e115876. (doi:10.1371/journal.pone.0115876)

Blair, A., Stevenson, L., Dewar, D., Pimlott, S.L. and Sutherland, A. (2013) Structure–activity relationships of novel iodinated quinoline-2-carboxamides for targeting the translocator protein. MedChemComm, 4(11), pp. 1461-1466. (doi:10.1039/c3md00249g)

Tarr, D., Graham, D., Roy, L.A., Holmes, W.M., McCabe, C. , Macrae, I.M., Muir, K.W. and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33(10), pp. 1556-1563. (doi:10.1038/jcbfm.2013.107)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A., Pimlott, S.L., Batis, J., Barret, O., Seibyl, J. and Tamagnan, G. (2012) Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography. Synapse, 66(11), pp. 923-930. (doi:10.1002/syn.21585)

Tavares, A.A.S., Lewsey, J., Dewar, D. and Pimlott, S.L. (2012) Radiotracer properties determined by high performance liquid chromatography: a potential tool for brain radiotracer discovery. Nuclear Medicine and Biology, 39(1), pp. 127-135. (doi:10.1016/j.nucmedbio.2011.06.011)

Ruest, T., Holmes, W.M., Barrie, J.A., Griffiths, I.R., Anderson, T.J. , Dewar, D. and Edgar, J.M. (2011) High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR in Biomedicine, 24(10), pp. 1369-1379. (doi:10.1002/nbm.1700)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A. and Pimlott, S.L. (2011) Development of the radiosynthesis of high-specific-activity 123I-NKJ64. Nuclear Medicine and Biology, 38(4), pp. 493-500. (doi:10.1016/j.nucmedbio.2010.11.011)

Moldrich, R.X. et al. (2011) Fgfr3 regulates development of the caudal telencephalon. Developmental Dynamics, 240(6), pp. 1586-1599. (doi:10.1002/dvdy.22636)

Tavares, A.A.S., Jobson, N.K., Dewar, D., Sutherland, A. and Pimlott, S.L. (2011) 123I-NKJ64: A novel single photon emission computed tomography radiotracer for imaging the noradrenaline transporter in brain. Synapse, 65(7), pp. 658-667. (doi:10.1002/syn.20895)

Tavares, A., Dewar, D., Sutherland, A. and Pimlott, S. (2010) (R,S)-2-Iodo-reboxetine: development as a novel SPECT radiotracer for imaging the noradrenaline transporter in brain. NeuroImage, 52(S1), S115-S115. (doi:10.1016/j.neuroimage.2010.04.094)

Cavanagh, J., Patterson, J., Pimlott, S.L., Wyper, D.J. and Dewar, D. (2010) SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the 42 nicotinic acetylcholine receptor [123I]5-I-A85380 ligand: in vivo and in vitro evidence. Synapse, 64(2), pp. 111-116. (doi:10.1002/syn.20705)

Lewis, D.Y., Champion, S., Dewar, D., Honey, G., Gross, J., Robichaud, A.J., Welch, A., Wyper, D. and Pimlott, S. (2010) Characterisation of novel histamine H3 receptor tracers for SPECT. Molecular Imaging and Biology, 12(S122), pp. 462-493.

Stevenson, L., Tavares, A.A.S., Brunet, A., McGonagle, F.I., Dewar, D., Pimlott, S.L. and Sutherland, A. (2010) New iodinated quinloine-2-varboxamides for SPECT imaging of the translocator protein. Bioorganic and Medicinal Chemistry Letters, 20(3), pp. 954-957. (doi:10.1016/j.bmcl.2009.12.061)

Cain, S.M., Ruest, T., Pimlott, S.L., Patterson, J., Duncan, R.D., Dewar, D. and Sills, G.J. (2009) High resolution micro-SPECT scanning in rats using I-125 beta-CIT: Effects of chronic treatment with carbamazepine. Epilepsia, 50(8), pp. 1962-1970. (doi:10.1111/j.1528-1167.2009.02095.x)

Champion, S., Lewis, D., Dewar, D., Honey, G., Gross, J., Robichaud, A., Welch, A., Wyper, D. and Pimlott, S. (2009) Radiosynthesis and evaluation of novel histamine H3 tracers. Journal of Labelled Compounds and Radiopharmaceuticals, 52(S1), S381.

Jobson, N., Crawford, A., Dewar, D., Pimlott, S. and Sutherland, A. (2009) Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 19(17), pp. 4996-4998. (doi:10.1016/j.bmcl.2009.07.064)

Lewis, D., Champion, S., Dewar, D., Honey, G., Gross, J., Robichaud, A., Welch, A., Wyper, D. and Pimlott, S. (2009) Characterisation of Novel Histamine H3 receptor tracers for SPECT. Journal of Labelled Compounds and Radiopharmaceuticals, 52(S1), S381. (doi:10.1002/jlcr.1646)

MacKenzie, S. M., Dewar, D., Stewart, W. , Fraser, R., Connell, J. M. C. and Davies, E. (2008) The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. Journal of Endocrinology, 196(1), pp. 123-130. (doi:10.1677/JOE-07-0427)

Jobson, N., Crawford, A., Dewar, D., Pimlott, S. and Sutherland, A. (2008) New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 18(18), pp. 4940-4943. (doi:10.1016/j.bmcl.2008.08.041)

Jobson, N., Spike, R., Crawford, A., Dewar, D., Pimlott, S. and Sutherland, A. (2008) Stereoselective synthesis of (2S,3R)- and (2R,3S)-iodoreboxetine; potential SPECT imaging agents for the noradrenaline transporter. Organic and Biomolecular Chemistry, 6(13), pp. 2369-2376. (doi:10.1039/b802819b)

De Michele, M., Sette, G., Chalmers, D., Dewar, D., Toni, D., Sancesario, G. and McCulloch, J. (2007) Focal cerebral ischaemia induces corticotropin releasing factor (CRF) vascular immunoreactivity in rat occluded hemisphere. Regulatory Peptides, 143, pp. 69-75. (doi:10.1016/j.regpep.2007.03.004)

Dewar, D., Bentley, D. and Barnett, S. (2007) Implantation of pure cultured olfactory ensheathing cells in an animal model of parkinsonism. Acta Neurochirurgica, 149(4), pp. 407-414. (doi:10.1007/s00701-007-1121-5)

Cavanagh, J., Patterson, J., Pimlott, S., Dewar, D., Eersels, J., Dempsey, M. and Wyper, D. (2006) Serotonin transporter residual availability during long-term antidepressant therapy does not differentiate responder and nonresponder unipolar patients. Biological Psychiatry, 59, pp. 301-308. (doi:10.1016/j.biopsych.2005.06.029)

Cuthill, D., Fowler, J., McCulloch, J. and Dewar, D. (2006) Different patterns of axonal damage after intracerebral injection of malonate or AMPA. Experimental Neurology, 200, pp. 509-520. (doi:10.1016/j.expneurol.2006.03.021)

Fowler, J., Edgar, J., Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I., Garbern, J., Nave, K. and Dewar, D. (2006) alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. Journal of Neuroscience Research, 84, pp. 68-77. (doi:10.1002/jnr.20859)

Kennedy, L., Shelbourne, P. and Dewar, D. (2005) Alterations in dopamine and benzodiazepine receptor binding precede overt neuronal pathology in mice modelling early Huntington disease pathogenesis. Brain Research, 1039, pp. 14-21. (doi:10.1016/j.brainres.2005.01.029)

Culpan, D., MacGowan, S.H., Ford, J.M., Nicoll, J.A.R., Griffin, W.S., Dewar, D., Cairns, N.J., Hughes, A., Kehoe, P.G. and Wilcock, G.K. (2003) Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease. Neuroscience Letters, 350(1), pp. 61-65. (doi:10.1016/S0304-3940(03)00854-1)

Dewar, D., Underhill, S. and Goldberg, T. (2003) Oligodendrocytes and ischemic brain injury. Journal of Cerebral Blood Flow and Metabolism, 23, pp. 263-274. (doi:10.1097/01.WCB.0000053472.41007.F9)

Fowler, J., McCracken, E., Dewar, D. and McCulloch, J. (2003) Intracerebral injection of AMPA causes axonal damage in vivo. Brain Research, 991, pp. 104-112. (doi:10.1016/j.brainres.2003.08.004)

McCracken, E., Dewar, D. and McCulloch, J. (2003) Sipatrigine and oligodendrocyte and axonal pathology following transient focal cerebral ischaemia in the rat. NeuroReport, 14, pp. 517-520. (doi:10.1097/01.wnr.0000059627.96928.1b)

McCracken, E., Fowler, J., Dewar, D., Morrison, S. and McCulloch, J. (2002) Grey matter and white matter ischemic damage is reduced by the competitive AMPA receptor antagonist, SPD 502. Journal of Cerebral Blood Flow and Metabolism, 22, pp. 1090-1097.

Murdoch, I., Nicoll, J., Graham, D. and Dewar, D. (2002) Nucleus basalis of Meynert pathology in the human brain after fatal head injury. Journal of Neurotrauma, 19, pp. 279-284.

Dewar, D. (2001) The absence of HLA-DRB1*03 is a risk factor in Alzheimer's disease. Alzheimer's Reports, 4, pp. 109-114.

Imai, H., Masayasu, H., Dewar, D., Graham, D. and Macrae, I. (2001) Ebselen protects both gray model of focal and white matter in a rodent cerebral ischemia. Stroke, 32, pp. 2149-2156.

McCracken, E., Dewar, D. and Hunter, A. (2001) White matter damage following systemic injection of the mitochondrial inhibitor 3-nitropropionic acid in rat. Brain Research, 892, pp. 329-335.

This list was generated on Mon May 22 06:54:12 2017 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Corticospinal reorganisation after experimental stroke.
    Neurosciences Foundation
    2012 - 2013
     
  • Visualisation of activated microglia in traumatic brain injury: an in vitro autoradiography study in human post-mortem brain tissue
    NHS Greater Glasgow & Clyde, Endowment Funds Office
    2010 - 2011
     
  • Metabolic syndrome, hyperglycemia and experimental stroke
    Scottish Executive Health Department
    2009 - 2010
     
  • Experimental validation by micro-SPECT of two different radioligands for imaging serotin transporter density
    Neurosciences Foundation
    2007 - 2008
     
  • Evaluation of antiepileptic drug action using in vivo micro-SPECT imaging
    Epilepsy Research Foundation
    2006 - 2007
     
  • A Pilot Study to Optimise High Resolution Magnetic Resonance Microscopy Imaging of fixed brain tissue from modified mice
    Neurosciences Foundation
    2006 - 2006
     
  • Development of a molecular imaging tracer for the noradrenaline transporter
    Scottish Hospital Endowments Research Trust
    2006 - 2008
     
  • Image analysis equipment for neurotransmitter autoradiography
    Tenovus-Scotland
    2006 - 2006
     
  • The use of olfactory epithelial stem cells for CNS repair
    MRC
    2004 - 2007