- Research Fellow (Stroke and Brain Imaging)
We use MRI to track the evolution of ischaemic damage following stroke (diffusion weighted imaging, perfusion weighted imaging, T2 weighted imaging etc), particularly during the acute phase, allowing us to follow the lifespan of potentially salvageable tissue (ischaemic penumbra). We are investigating whether there are differences in the evolution of ischaemic damage in focal ischaemia models exhibiting known stroke risk factors (hypertension, sex, hyperglycaemia) with a view to identifying potential neuroprotective targets.
I am also interested in the role of NADPH oxidase, the major source of superoxide production in the brain, following stroke. Increasing evidence has shown that inhibition of NADPH oxidase is neuroprotective following stroke. We are investigating the role of NADPH oxidase inhibition during the acute phase following stroke.
Another key research interest is concerned with the development of novel MRI techniques for imaging the ischaemic penumbra following stroke.