Dr Chris Mccabe

  • Research Fellow (Stroke and Brain Imaging)

telephone: 01413305822
email: Chris.McCabe@glasgow.ac.uk

R202 Level 2
Wellcome Surgical Institute
Glasgow G61 1QH


We use MRI to track the evolution of ischaemic damage following stroke (diffusion weighted imaging, perfusion weighted imaging, T2 weighted imaging etc), particularly during the acute phase, allowing us to follow the lifespan of potentially salvageable tissue (ischaemic penumbra). We are investigating whether there are differences in the evolution of ischaemic damage in focal ischaemia models exhibiting known stroke risk factors (hypertension, sex, hyperglycaemia) with a view to identifying potential neuroprotective targets.

I am also interested in the role of NADPH oxidase, the major source of superoxide production in the brain, following stroke. Increasing evidence has shown that inhibition of NADPH oxidase is neuroprotective following stroke. We are investigating the role of NADPH oxidase inhibition during the acute phase following stroke.

Another key research interest is concerned with the development of novel MRI techniques for imaging the ischaemic penumbra following stroke.

List all by: Type | Date

Jump to: 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2006 | 2005
Number of items: 27.

2013

Ord, Emily N. J., Shirley, Rachel, McClure, John D., McCabe, Christopher, Kremer, Eric J., Macrae, I. Mhairi, and Work, Lorraine M (2013) Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats. Journal of Cerebral Blood Flow and Metabolism, 33 (8). pp. 1215-1224. ISSN 0271-678X (doi:10.1038/jcbfm.2013.70)

Brittain, J.F. et al. (2013) An MRI-histological study of white matter in stroke-free SHRSP. Journal of Cerebral Blood Flow and Metabolism, 33 (5). pp. 760-763. ISSN 0271-678X (doi:10.1038/jcbfm.2013.14)

Tarr, D., Graham, D., Roy, L.A., Holmes, W.M., McCabe, C., Macrae, I.M., Muir, K.W., and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33 (10). pp. 1556-1563. ISSN 0271-678X (doi:10.1038/jcbfm.2013.107)

2012

Ord, Emily N. J., Shirley, Rachel, van Kralingen, Josie C., Graves, Alice, McClure, John D., Wilkinson, Michael, McCabe, Christopher, Macrae, I. Mhairi, and Work, Lorraine M. (2012) Positive impact of pre-stroke surgery on survival following transient focal ischemia in hypertensive rats. Journal of Neuroscience Methods, 211 (2). pp. 305-308. ISSN 0165-0270 (doi:10.1016/j.jneumeth.2012.09.001)

Reid, E., Graham, D., Lopez-Gonzalez, M.R., Holmes, W.M., Macrae, I.M., and McCabe, C. (2012) Penumbra detection using PWI/DWI mismatch MRI in a rat stroke model with and without comorbidity: comparison of methods. Journal of Cerebral Blood Flow and Metabolism, 32 (9). pp. 1765-1777. ISSN 0271-678X (doi:10.1038/jcbfm.2012.69)

Baskerville, T.A., McCabe, C., Weir, C.J., Macrae, I.M., and Holmes, W.M. (2012) Non-invasive MRI measurement of CBF: evaluating an arterial spin labelling sequence with 99mTc-HMPAO CBF autoradiography in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism, 32 (6). pp. 973-977. ISSN 0271-678X (doi:10.1038/jcbfm.2012.19)

Baskerville, T., McCabe, C., Weir, C.J., Macrae, I.M., and Holmes, W. (2012) Noninvasive MRI measurement of CBF: evaluating an arterial spin labelling sequence with 99mTc- HMPAO CBF autoradiography in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism, 32 (6). pp. 973-977. ISSN 0271-678X (doi:10.1038/jcbfm.2012.19)

2011

Baskerville, Tracey, Deuchar, Graeme A., McCabe, Chris, Robertson, Craig A., Holmes, William M., Santosh, Celestine, and Macrae, I. Mhairi (2011) Influence of 100% and 40% oxygen on penumbral blood flow, oxygen level, and T2*-weighted MRI in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism, 31 (8). pp. 1799-1806. ISSN 0271-678X (doi:10.1038/jcbfm.2011.65)

Robertson, Craig A., McCabe, Chris, Gallagher, Lindsay, Lopez Gonzalez, Maria del, Holmes, William M., Condon, Barrie, Muir, Keith W., Santosh, Celestine, and Macrae, I. Mhairi (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion. Journal of Cerebral Blood Flow and Metabolism, 31 (8). pp. 1788-1798. ISSN 0271-678X (doi:10.1038/jcbfm.2011.67)

Robertson, Craig A., McCabe, Chris, Gallagher, Lindsay, Lopez-Gonzalez, Maria del., Holmes, William M., Condon, Barrie, Muir, Keith W., Santosh, Celestine, and Macrae, I. Mhairi (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography. Journal of Cerebral Blood Flow and Metabolism, 31 . pp. 1778-1787. ISSN 0271-678X (doi:10.1038/jcbfm.2011.66)

Rodgers, Jean, McCabe, Chris, Gettinby, George, Bradley, Barbara, Condon, Barrie, and Kennedy, Peter G.E. (2011) Magnetic Resonance Imaging to Assess Blood-Brain Barrier Damage in Murine Trypanosomiasis. American Journal of Tropical Medicine and Hygiene, 84 (2). pp. 344-350. ISSN 0002-9637 (doi:10.4269/ajtmh.2011.10-0487)

Rodgers, Jean, Jones, Amy, Gibaud, Stephane, Bradley, Barbara, McCabe, Chris, Barrett, Michael P., Gettinby, George, and Kennedy, Peter G.E. (2011) Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 5 (9). e1308. ISSN 1935-2727 (doi:10.1371/journal.pntd.0001308)

2010

Dani, Krishna A., Santosh, Celestine, Brennan, David, McCabe, Chris, Holmes, William M., Condon, Barrie, Hadley, Donald M., Macrae, I. Mhairi, Shaw, Martin, and Muir, Keith W. (2010) T2*-weighted magnetic resonance imaging with hyperoxia in acute ischemic stroke. Annals of Neurology, 68 (1). pp. 37-47. ISSN 0364-5134 (doi:10.1002/ana.22032)

McCabe, C., Gallagher, L., Macrae, I.M., Gsell, W., Graham, D., and Dominiczak, A.F. (2010) Response to letter by Yao (Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats). Stroke, 41 (4). E198-E199. ISSN 0039-2499 (doi:10.1161/STROKEAHA.109.575704)

2009

McCabe, Christopher, Gallagher, Lindsay, Gsell, Willy, Graham, Delyth, Dominiczak, Anna F., and Macrae, I. Mhairi (2009) Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Stroke, 40 (12). pp. 3864-3868. ISSN 0039-2499 (doi:10.1161/STROKEAHA.109.559021)

Holmes, W.H., McCabe, C., Mullin, J.M., Condon, B., and Bain, M.M. (2009) In ovo non-invasive quantification of the myocardial function and mass of chick embryos using magnetic resonance imaging. NMR in Biomedicine, 22 (7). pp. 745-752. ISSN 0952-3480 (doi:10.1002/nbm.1386)

Brand, Oliver J. et al. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906 (doi:10.1093/hmg/ddp087)

2008

Santosh, Celestine et al. (2008) Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra. Journal of Cerebral Blood Flow and Metabolism, 28 (10). pp. 1742-1753. ISSN 0271-678X (doi:10.1038/jcbfm.2008.56)

Holmes, W.M., McCabe, C., Mullin, J.M., Condon, B., and Bain, M.M. (2008) Noninvasive self-gated magnetic resonance cardiac imaging of developing chick embryos in ovo. Circulation, 117 (21). E346-E347. ISSN 0009-7322 (doi:10.1161/CIRCULATIONAHA.107.747154 )

McCabe, C., White, F., Brown, S.M., and Macrae, I.M. (2008) GADD34 gene restores virulence in viral vector used in experimental stroke study. Journal of Cerebral Blood Flow and Metabolism, 28 (4). pp. 747-751. ISSN 0271-678X (doi:10.1038/sj.jcbfm.9600565)

Lecrux, C., McCabe, C., Weir, C.J., Gallagher, L., Mullin, J., Touzani, O., Muir, K., Lees, K.R., and Macrae, I.M. (2008) Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats. Stroke, 39 (2). pp. 448-454. ISSN 0039-2499 (doi:10.1161/STROKEAHA.107.492934)

Claxton, K., Briggs, A.H., Buxton, M.J., Culyer, A.J., McCabe, C., Walker, S., and Sculpher, M.J. (2008) Value based pricing for NHS drugs: an opportunity not to be missed? British Medical Journal, 336 (7638). pp. 251-254. ISSN 0959-535X (doi:10.1136/bmj.39434.500185.25)

2006

Morton, E., Macrae, I.M., McCabe, C., Brown, S.M., and White, F. (2006) Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia. International Journal of Cardiology, 107 (1). pp. 126-129. ISSN 0167-5273 (doi:10.1016/j.ijcard.2005.01.051)

2005

Claxton, K., Sculpher, M., McCabe, C., Briggs, A.H., Akehurst, R., Buxton, M., Brazier, J., and O'Hagan, T. (2005) Probabilistic sensitivity analysis for NICE technology assessment: not an optional extra. Health Economics, 14 (4). pp. 339-347. ISSN 1057-9230 (doi:10.1002/hec.985)

McCabe, C, Hicks, MN, Kane, KA, and Wainwright, CL (2005) Electrophysiological and haemodynamic effects of endothelin ETA and ETB receptors in normal and ischaemic working rabbit hearts. British Journal of Pharmacology, 146 . pp. 118-128. (doi:10.1038/sj.bjp.0706304)

O'Hagan, T. et al. (2005) Incorporation of uncertainty in health economic modelling studies. PharmacoEconomics, 23 (6). pp. 529-536. ISSN 1170-7690

Wainwright, C.L., McCabe, C., and Kane, K.A. (2005) Endothelin and the ischaemic heart. Current Vascular Pharmacology, 3 (4). pp. 333-341. ISSN 1570-1611

This list was generated on Tue Jul 22 12:52:50 2014 BST.
Jump to: Article
Number of items: 27.

Article

Ord, Emily N. J., Shirley, Rachel, McClure, John D., McCabe, Christopher, Kremer, Eric J., Macrae, I. Mhairi, and Work, Lorraine M (2013) Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats. Journal of Cerebral Blood Flow and Metabolism, 33 (8). pp. 1215-1224. ISSN 0271-678X (doi:10.1038/jcbfm.2013.70)

Brittain, J.F. et al. (2013) An MRI-histological study of white matter in stroke-free SHRSP. Journal of Cerebral Blood Flow and Metabolism, 33 (5). pp. 760-763. ISSN 0271-678X (doi:10.1038/jcbfm.2013.14)

Tarr, D., Graham, D., Roy, L.A., Holmes, W.M., McCabe, C., Macrae, I.M., Muir, K.W., and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33 (10). pp. 1556-1563. ISSN 0271-678X (doi:10.1038/jcbfm.2013.107)

Ord, Emily N. J., Shirley, Rachel, van Kralingen, Josie C., Graves, Alice, McClure, John D., Wilkinson, Michael, McCabe, Christopher, Macrae, I. Mhairi, and Work, Lorraine M. (2012) Positive impact of pre-stroke surgery on survival following transient focal ischemia in hypertensive rats. Journal of Neuroscience Methods, 211 (2). pp. 305-308. ISSN 0165-0270 (doi:10.1016/j.jneumeth.2012.09.001)

Reid, E., Graham, D., Lopez-Gonzalez, M.R., Holmes, W.M., Macrae, I.M., and McCabe, C. (2012) Penumbra detection using PWI/DWI mismatch MRI in a rat stroke model with and without comorbidity: comparison of methods. Journal of Cerebral Blood Flow and Metabolism, 32 (9). pp. 1765-1777. ISSN 0271-678X (doi:10.1038/jcbfm.2012.69)

Baskerville, T.A., McCabe, C., Weir, C.J., Macrae, I.M., and Holmes, W.M. (2012) Non-invasive MRI measurement of CBF: evaluating an arterial spin labelling sequence with 99mTc-HMPAO CBF autoradiography in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism, 32 (6). pp. 973-977. ISSN 0271-678X (doi:10.1038/jcbfm.2012.19)

Baskerville, T., McCabe, C., Weir, C.J., Macrae, I.M., and Holmes, W. (2012) Noninvasive MRI measurement of CBF: evaluating an arterial spin labelling sequence with 99mTc- HMPAO CBF autoradiography in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism, 32 (6). pp. 973-977. ISSN 0271-678X (doi:10.1038/jcbfm.2012.19)

Baskerville, Tracey, Deuchar, Graeme A., McCabe, Chris, Robertson, Craig A., Holmes, William M., Santosh, Celestine, and Macrae, I. Mhairi (2011) Influence of 100% and 40% oxygen on penumbral blood flow, oxygen level, and T2*-weighted MRI in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism, 31 (8). pp. 1799-1806. ISSN 0271-678X (doi:10.1038/jcbfm.2011.65)

Robertson, Craig A., McCabe, Chris, Gallagher, Lindsay, Lopez Gonzalez, Maria del, Holmes, William M., Condon, Barrie, Muir, Keith W., Santosh, Celestine, and Macrae, I. Mhairi (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion. Journal of Cerebral Blood Flow and Metabolism, 31 (8). pp. 1788-1798. ISSN 0271-678X (doi:10.1038/jcbfm.2011.67)

Robertson, Craig A., McCabe, Chris, Gallagher, Lindsay, Lopez-Gonzalez, Maria del., Holmes, William M., Condon, Barrie, Muir, Keith W., Santosh, Celestine, and Macrae, I. Mhairi (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography. Journal of Cerebral Blood Flow and Metabolism, 31 . pp. 1778-1787. ISSN 0271-678X (doi:10.1038/jcbfm.2011.66)

Rodgers, Jean, McCabe, Chris, Gettinby, George, Bradley, Barbara, Condon, Barrie, and Kennedy, Peter G.E. (2011) Magnetic Resonance Imaging to Assess Blood-Brain Barrier Damage in Murine Trypanosomiasis. American Journal of Tropical Medicine and Hygiene, 84 (2). pp. 344-350. ISSN 0002-9637 (doi:10.4269/ajtmh.2011.10-0487)

Rodgers, Jean, Jones, Amy, Gibaud, Stephane, Bradley, Barbara, McCabe, Chris, Barrett, Michael P., Gettinby, George, and Kennedy, Peter G.E. (2011) Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 5 (9). e1308. ISSN 1935-2727 (doi:10.1371/journal.pntd.0001308)

Dani, Krishna A., Santosh, Celestine, Brennan, David, McCabe, Chris, Holmes, William M., Condon, Barrie, Hadley, Donald M., Macrae, I. Mhairi, Shaw, Martin, and Muir, Keith W. (2010) T2*-weighted magnetic resonance imaging with hyperoxia in acute ischemic stroke. Annals of Neurology, 68 (1). pp. 37-47. ISSN 0364-5134 (doi:10.1002/ana.22032)

McCabe, C., Gallagher, L., Macrae, I.M., Gsell, W., Graham, D., and Dominiczak, A.F. (2010) Response to letter by Yao (Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats). Stroke, 41 (4). E198-E199. ISSN 0039-2499 (doi:10.1161/STROKEAHA.109.575704)

McCabe, Christopher, Gallagher, Lindsay, Gsell, Willy, Graham, Delyth, Dominiczak, Anna F., and Macrae, I. Mhairi (2009) Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Stroke, 40 (12). pp. 3864-3868. ISSN 0039-2499 (doi:10.1161/STROKEAHA.109.559021)

Holmes, W.H., McCabe, C., Mullin, J.M., Condon, B., and Bain, M.M. (2009) In ovo non-invasive quantification of the myocardial function and mass of chick embryos using magnetic resonance imaging. NMR in Biomedicine, 22 (7). pp. 745-752. ISSN 0952-3480 (doi:10.1002/nbm.1386)

Brand, Oliver J. et al. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Human Molecular Genetics, 18 (9). pp. 1704-1713. ISSN 0964-6906 (doi:10.1093/hmg/ddp087)

Santosh, Celestine et al. (2008) Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra. Journal of Cerebral Blood Flow and Metabolism, 28 (10). pp. 1742-1753. ISSN 0271-678X (doi:10.1038/jcbfm.2008.56)

Holmes, W.M., McCabe, C., Mullin, J.M., Condon, B., and Bain, M.M. (2008) Noninvasive self-gated magnetic resonance cardiac imaging of developing chick embryos in ovo. Circulation, 117 (21). E346-E347. ISSN 0009-7322 (doi:10.1161/CIRCULATIONAHA.107.747154 )

McCabe, C., White, F., Brown, S.M., and Macrae, I.M. (2008) GADD34 gene restores virulence in viral vector used in experimental stroke study. Journal of Cerebral Blood Flow and Metabolism, 28 (4). pp. 747-751. ISSN 0271-678X (doi:10.1038/sj.jcbfm.9600565)

Lecrux, C., McCabe, C., Weir, C.J., Gallagher, L., Mullin, J., Touzani, O., Muir, K., Lees, K.R., and Macrae, I.M. (2008) Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats. Stroke, 39 (2). pp. 448-454. ISSN 0039-2499 (doi:10.1161/STROKEAHA.107.492934)

Claxton, K., Briggs, A.H., Buxton, M.J., Culyer, A.J., McCabe, C., Walker, S., and Sculpher, M.J. (2008) Value based pricing for NHS drugs: an opportunity not to be missed? British Medical Journal, 336 (7638). pp. 251-254. ISSN 0959-535X (doi:10.1136/bmj.39434.500185.25)

Morton, E., Macrae, I.M., McCabe, C., Brown, S.M., and White, F. (2006) Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia. International Journal of Cardiology, 107 (1). pp. 126-129. ISSN 0167-5273 (doi:10.1016/j.ijcard.2005.01.051)

Claxton, K., Sculpher, M., McCabe, C., Briggs, A.H., Akehurst, R., Buxton, M., Brazier, J., and O'Hagan, T. (2005) Probabilistic sensitivity analysis for NICE technology assessment: not an optional extra. Health Economics, 14 (4). pp. 339-347. ISSN 1057-9230 (doi:10.1002/hec.985)

McCabe, C, Hicks, MN, Kane, KA, and Wainwright, CL (2005) Electrophysiological and haemodynamic effects of endothelin ETA and ETB receptors in normal and ischaemic working rabbit hearts. British Journal of Pharmacology, 146 . pp. 118-128. (doi:10.1038/sj.bjp.0706304)

O'Hagan, T. et al. (2005) Incorporation of uncertainty in health economic modelling studies. PharmacoEconomics, 23 (6). pp. 529-536. ISSN 1170-7690

Wainwright, C.L., McCabe, C., and Kane, K.A. (2005) Endothelin and the ischaemic heart. Current Vascular Pharmacology, 3 (4). pp. 333-341. ISSN 1570-1611

This list was generated on Tue Jul 22 12:52:50 2014 BST.