Professor Susan Barnett

  • Professor of Cellular Neuroscience (Immunology)

telephone: 01413308409
email: Susan.Barnett@glasgow.ac.uk

Research interests

Professor Sue Barnett leads the Glial Cell Biology Group within the Institute of Infection Immunity and Inflammation. The group focuses on the use of glial cells for central nervous system (CNS) repair. Glial cells are the major cells in the peripheral and central nervous system (PNS and CNS respectively) providing functional, structural and metabolic support for neurons. In the CNS the oligodendrocyte makes the myelin sheath that wraps around axons that is necessary for saltatory conduction. Damage to oligodendrocytes and the myelin sheath are common after injury (spinal cord injury) and in many neurological conditions (eg Multiple Sclerosis). The group are taking two approaches to promote CNS repair. The first involves a cell replacement strategy using specialised glial cells from the olfactory system known as olfactory ensheathing cells (OECs) as well as a recently identified stem cell from the olfactory mucosa, termed lamina propria-MSCs. Both cells have a positive effect on myelination. The second involves manipulations of oligodendrocytes to facilitate process extension, axon ensheathment and myelination.
The group have also made detailed comparison of OECs and Schwann cells. They have shown that OECs, although sharing many properties in common with Schwann cells, have discrete biological differences which allow them to mingle with astrocytes and promote CNS repair. Our lab continues to investigate how these cells differ. Using human olfactory biopsy tissue we have identified a novel mesenchymal stem cells which appears to have advantages over classical MSCs in promoting myelination. Recently focus has turned to the astrocyte where our research has shown their phenotype can influence myelination in particular by the secretion of a range of chemokines. Ongoing microarray analyses of these various astrocyte phenotypes are identifying novel candidates for promoting and inhibiting myelination.
We have developed many in vitro models of CNS injury and demyelination and continue to strive to identify novel approaches for the promotion of CNS repair.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Implanted imaging laboratories for deep-tissue in vivo imaging
    National Centre for Replacement,Refinement and Reduction of
    2014 - 2017
     
  • Novel strategies for promoting CNS repair through manipulation of FGF signalling and heparan sulphate proteoglycans
    Medical Research Council
    2013 - 2015
     
  • The Development of a Rat In Vitro Model of SCI Demonstrating the Additive Effects of Rho andROCK Inhibitors on neurite.
    National Centre for Replacement,Refinement and Reduction of
    2013 - 2015
     
  • The Development of a Rat In Vitro Model of SCI Demonstrating the Additive Effects of Rho andROCK Inhibitors on neurite.
    National Centre for Replacement,Refinement and Reduction of
    2013 - 2015
     
  • Does cellular niche affect the repair potential of mesenchymal stem cells; implications for spinal cord injury?
    Medical Research Council
    2012 - 2015
     
  • How does function in long axonal tracts and local circuits change in the progression from acute to chronic stages of spinal cord injury and how effective are cell transplants?
    International Spinal Research Trust
    2011 - 2014
     
  • Can olfactory mesenchymal stem cells influence the repair potential of olfactory ensheathing cells?
    Wings for Life - Spinal Cord Research Foundation
    2010 - 2011
     
  • Neurofascin specific autoantibodies and the pathogenesis of MS
    Multiple Sclerosis Society
    2010 - 2013
     
  • Micro Engineered Constructs for CNS repair
    BBSRC
    2009 - 2012
     
  • The development of an in vitro model of CNS injury to identify factors which promote repair.
    National Centre for Replacement,Refinement and Reduction of
    2009 - 2012
     
  • Manipulation of heparan sulphate proteoglycans as a strategy for promoting brain repair
    Wellcome Trust
    2009 - 2012
     
  • Do experimental treatments for spinal cord injury induce functional plasticity in spared pathways?
    International Spinal Research Trust
    2008 - 2011
     
  • Characterisation of olfactory glial and stem cells from human olfactory mucosa
    Scottish Executive Health Department
    2008 - 2010
     
  • Neuroinflammation and Neurobiology Value In People Awards
    Wellcome Trust
    2008 - 2008
     
  • Do transplants of olfactory ensheathing cells promote increased sparing in a spinal cord contusion injury model?
    Tenovus-Scotland
    2007 - 2008
     
  • Characterisation of the factors that distinguish the different migratory properties of Schwann cells and olfactory ensheathing cells within.
    Wellcome Trust
    2005 - 2008
     
  • The use of olfactory epithelial stem cells for CNS repair
    MRC
    2004 - 2007
     
  • Role of AP-1 and its possible target Mayven, in oligodendrocyte process formation
    Multiple Sclerosis Society
    2001 - 2005
     

Additional information

Editorial Board

  • 2011 - ongoing: Conference Papers in Neurosciences
  • 2011 - ongoing: Glia
  • 2010 - ongoing: ISRN Neurology
  • 2010 - ongoing: Frontiers in Neurorestoratology - Review Editorial Board

Grant Advisory Board

  • 2013 - ongoing: XI European Meeting on Glial Cells in Health and Disease, Berlin - Programme Committee Chair
  • 2011 - ongoing: Crack-it - Translational Review Pancel C Member
  • 2010 - ongoing: Spinal Research - Scientific Committee Chair
  • 2006 - ongoing: MS Society - Grant Review Panel Board Member
  • 2006 - 2008: MS Society - Grant Review Panel 1 Board Member
  • 2005 - ongoing: NMHB - MRC Special Review Panel Member
  • 2004 - ongoing: Spinal Research - Scientific Committee Member
  • 2004 - 2007: MRC - Member, College of Experts
  • 2003 - ongoing: CCLRC - Expert Referee, New Technology Partnership Programme
  • 2000 - 2006: MS Society for UK and Ireland - Member, Glial Biology Section
  • 2000 - 2004: MRC - Advisory Board Member

Prizes, Awards and Distinctions

  • 2011: ESNI - 11th ESNI Career Award for Recognition of Outstanding Contribution to Neuroimmunology
  • 2010: Society of Biology - Elected Fellow (FSB)
  • 2008: International Spinal Research Trust - Recipient of Robson Award (with Dr. J. Riddell), in recognition of top ranked research grant proposal in 2008 funding round

Research Fellowship

  • 1995 - 2000: Wellcome Trust University Award

Publications

List by: Type | Date

Jump to: 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1996 | 1993
Number of items: 54.

2014

Donoghue, P. S., Sun, T., Gadegaard, N., Riehle, M. O., and Barnett, S. C. (2014) Development of a novel 3D culture system for screening features of a complex implantable device for CNS repair. Molecular Pharmaceutics, 11 (7). pp. 2143-2150. ISSN 1543-8384 (doi:10.1021/mp400526n)

Boomkamp, S. D., McGrath, M. A., Houslay, M. D., and Barnett, S. C. (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. British Journal of Pharmacology, 171 (9). pp. 2385-2398. ISSN 0007-1188 (doi:10.1111/bph.12588)

Ioannidou, K., Anderson, K. I., Strachan, D., Edgar, J. M., and Barnett, S. C. (2014) Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques. BMC Neuroscience, 15 (1). p. 59. ISSN 1471-2202 (doi:10.1186/1471-2202-15-59)

2013

Toft, A., Tome, M., Barnett, S.C., and Riddell, J.S. (2013) A comparative study of glial and non-neural cell properties for transplant-mediated repair of the injured spinal cord. Glia, 61 (4). pp. 513-528. ISSN 0894-1491 (doi:10.1002/glia.22452)

Lindsay, S.L., Johnstone, S.A., Mountford, J.C., Sheikh, S., Allan, D.B., Clark, L., and Barnett, S.C. (2013) Human mesenchymal stem cells isolated from olfactory biopsies but not bone enhance CNS myelinationin vitro. Glia, 61 (3). pp. 368-382. ISSN 0894-1491 (doi:10.1002/glia.22440)

Donoghue, P.S., Lamond, R., Boomkamp, S.D., Tao, S., Gadegaard, N., Riehle, M.O., and Barnett, S.C. (2013) The development of a ε-polycaprolactone (PCL) scaffold for CNS repair. Tissue Engineering Part A, 19 (3). ISSN 1937-3341 (doi:10.1089/ten.TEA.2012.0382)

Barnett, S.C., and Linington, C. (2013) Myelination: do astrocytes play a role? Neuroscientist, 19 (5). pp. 442-450. ISSN 1073-8584 (doi:10.1177/1073858412465655)

Lamond, R., and Barnett, S.C. (2013) Schwann cells but not olfactory ensheathing cells inhibit CNS myelination via the secretion of connective tissue growth factor. Journal of Neuroscience, 33 (47). pp. 18686-18697. ISSN 0270-6474 (doi:10.1523/JNEUROSCI.3233-13.2013)

Moleirinho, S. et al. (2013) KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals. Oncogene, 32 (14). pp. 1821-1830. ISSN 0950-9232 (doi:10.1038/onc.2012.196)

Moleirinho, S., Patrick, C., Tilston-Lünel, A.M., Higginson, J.R., Angus, L., Antkowiak, M., Barnett, S.C., Prystowsky, M.B., Reynolds, P.A., and Gunn-Moore, F.J. (2013) Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts. PLoS ONE, 8 (4). e60028. ISSN 1932-6203 (doi:10.1371/journal.pone.0060028)

Sun, T., Donoghue, P.S., Higginson, J.R., Gadegaard, N., Barnett, S.C., and Riehle, M.O. (2013) A miniaturized bioreactor system for the evaluation of cell interaction with designed substrates in perfusion culture. Journal of Tissue Engineering and Regenerative Medicine, 6 (S3). S4-S14. ISSN 1932-6254 (doi:10.1002/term.510)

2012

Higginson, J.R., Thompson, S.M., Santos-Silva, A., Guimond, S.E., Turnbull, J.E., and Barnett, S.C. (2012) Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation. Journal of Neuroscience, 32 (45). pp. 15902-15912. ISSN 0270-6474 (doi:10.1523/JNEUROSCI.6340-11.2012)

Sandvig, I. et al. (2012) In vivo MRI of olfactory ensheathing cell grafts and regenerating axons in transplant mediated repair of the adult rat optic nerve. NMR in Biomedicine, 25 (4). pp. 620-631. ISSN 0952-3480 (doi:10.1002/nbm.1778)

Toft, A., Tomé, M., Lindsay, S.L., Barnett, S.C., and Riddell, J.S. (2012) Transplant-mediated repair properties of rat olfactory mucosal OM-I and OM-II sphere-forming cells. Journal of Neuroscience Research, 90 (3). pp. 619-631. ISSN 0360-4012 (doi:10.1002/jnr.22789)

Boomkamp, S.D., Riehle, M.O., Wood, J., Olson, M.F., and Barnett, S.C. (2012) The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of rho and ROCK inhibitors on neurite outgrowth and myelination. Glia, 60 (3). pp. 441-456. ISSN 0894-1491 (doi:10.1002/glia.22278)

Elliott, C. et al. (2012) Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain, 135 (6). pp. 1819-1833. ISSN 0006-8950 (doi:10.1093/brain/aws105)

Ioannidou, K., Anderson, K.I., Strachan, D., Edgar, J.M., and Barnett, S.C. (2012) Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS ONE, 7 (1). e30775. ISSN 1932-6203 (doi:10.1371/journal.pone.0030775)

Sandvig, I., Hoang, L., Sardella, T.C.P., Barnett, S.C., Brekken, C., Tvedt, K., Berry, M., Haraldseth, O., Sandvig, A., and Thuen, M. (2012) Labelling of olfactory ensheathing cells with micron-sized particles of iron oxide and detection by MRI. Contrast Media and Molecular Imaging, 7 (4). pp. 403-410. ISSN 1555-4309 (doi:10.1002/cmmi.1465)

2011

Nash, B., Thomson, C.E., Linington, C., Arthur, A.T., McClure, J.D., McBride, M.W., and Barnett, S.C. (2011) Functional duality of astrocytes in myelination. Journal of Neuroscience, 31 (37). pp. 13028-13038. ISSN 0270-6474 (doi:10.1523/JNEUROSCI.1449-11.2011)

Sun, T., Donoghue, P.S., Higginson, J.R., Gadegaard, N., Barnett, S.C., and Riehle, M.O. (2011) The interactions of astrocytes and fibroblasts with defined pore structures in static and perfusion cultures. Biomaterials, 32 (8). pp. 2021-2031. ISSN 0142-9612 (doi:10.1016/j.biomaterials.2010.11.046)

Brennan, K.M. et al. (2011) Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. Journal of Neuroimmunology, 238 (1-2). pp. 87-95. ISSN 0165-5728 (doi:10.1016/j.jneuroim.2011.08.002)

Higginson, J.R., and Barnett, S.C. (2011) The culture of olfactory ensheathing cells (OECs)—a distinct glial cell type. Experimental Neurology, 229 (1). pp. 2-9. ISSN 0014-4886 (doi:10.1016/j.expneurol.2010.08.020)

2010

Lindsay, S.L., Riddell, J.S., and Barnett, S.C. (2010) Olfactory mucosa for transplant-mediated repair: a complex tissue for a complex injury? Glia, 58 (2). pp. 125-134. ISSN 0894-1491 (doi:10.1002/glia.20917)

Montague, P., Kennedy, P.G.E., and Barnett, S.C. (2010) Subcellular localization of Mayven following expression of wild type and mutant EGFP tagged cDNAs. BMC Neuroscience, 11 (1). p. 63. ISSN 1471-2202 (doi:10.1186/1471-2202-11-63)

Nash, B., Ioannidou, K., and Barnett, S.C. (2010) Astrocyte phenotypes and their relationship to myelination. Journal of Anatomy, 219 (1). pp. 44-52. ISSN 0021-8782 (doi:10.1111/j.1469-7580.2010.01330.x)

2009

Tome, M., Lindsay, S. L., Riddell, J. S., and Barnett, S. C. (2009) Identification of nonepithelial multipotent cells in the embryonic olfactory mucosa. Stem Cells, 27 (9). pp. 2196-2208. ISSN 1066-5099 (doi:10.1002/stem.130)

Eisenbach, M., Kartvelishvily, E., Eshed-Eisenbach, Y., Watkins, T., Sorensen, A., Thomson, C., Ranscht, B., Barnett, S., Brophy, P., and Peles, E. (2009) Differential Clustering of Caspr by Oligodendrocytes and Schwann Cells. Journal of Neuroscience Research, 87 (15). pp. 3492-3501. ISSN 0360-4012 (doi:10.1002/jnr.22157 )

Lamond, R., Donoghue, P., Gadegaard, N., Riehle, M., and Barnett, S. (2009) Developing a biodegradable construct to enhance axonal alignment following a spinal cord injury. Glia, 57 (13). S162-S162. ISSN 0894-1491

Silajdzic, E., Willison, H., Furukawa, K., and Barnett, S. (2009) In Vitro Analysis of Glial Cell Function in Ganglioside-deficient Mice. Journal of Neuroscience Research, 87 (11). pp. 2467-2483. ISSN 0360-4012 (doi:10.1002/jnr.22085 )

2008

Thomson, C.E., McCulloch, M., Sorenson, A., Barnett, S.C., Seed, B.V., Griffiths, I.R., and McLaughlin, M. (2008) Myelinated, synapsing cultures of murine spinal cord - validation as an in vitro model of the central nervous system. European Journal of Neuroscience, 28 (8). pp. 1518-1535. ISSN 0953-816X (doi:10.1111/j.1460-9568.2008.06415.x)

Sorensen, A., Moffat, K., Thomson, C., and Barnett, S. (2008) Astrocytes, but not olfactory ensheathing cells or Schwann cells, promote myelination of CNS axons in vitro. Glia, 56 (7). pp. 750-763. ISSN 0894-1491 (doi:10.1002/glia.20650 )

2007

Tomé, M., Siladžic, E., Santos-Silva, A., and Barnett, S. C. (2007) Calponin is expressed by subpopulations of connective tissue cells but not olfactory ensheathing cells in the neonatal olfactory mucosa. BMC Neuroscience, 8 (74). ISSN 1471-2202 (doi:10.1186/1471-2202-8-74)

Santos-Silva, A., Fairless, R., Frame, M.C., Montague, P., Smith, G.M., Toft, A., Riddell, J.S., and Barnett, S.C. (2007) FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis. Journal of Neuroscience, 27 (27). pp. 7154-7167. ISSN 0270-6474 (doi:10.1523/JNEUROSCI.1184-07.2007)

Barnett, S., and Riddell, J. (2007) Olfactory ensheathing cell transplantation as a strategy for spinal cord repair - what can it achieve? Nature Clinical Practice Neurology, 3 . pp. 152-161. (doi:10.1038/ncpneuro0447)

Dewar, D., Bentley, D., and Barnett, S. (2007) Implantation of pure cultured olfactory ensheathing cells in an animal model of parkinsonism. Acta Neurochirurgica, 149 . pp. 407-414. (doi:10.1007/s00701-007-1121-5)

Toft, A., Scott, D., Barnett, S., and Riddell, J. (2007) Electrophysiological evidence that olfactory cell transplants improve function after spinal cord injury. Brain, 130 . pp. 970-984. (doi:10.1093/brain/awm040)

2005

Fairless, R., and Barnett, S. (2005) Olfactory ensheathing cells: their role in central nervous system repair. International Journal of Biochemistry and Cell Biology, 37 . pp. 693-699. (doi:10.1016/j.biocel.2004.10.010)

Fairless, R., Frame, M., and Barnett, S. (2005) N-cadherin differentially determines Schwann cell and olfactory ensheathing cell adhesion and migration responses upon contact with astrocytes. Molecular and Cellular Neuroscience, 28 . pp. 253-263. (doi:10.1016/j.mcn.2004.09.009)

Williams, S., Spence, H., Rodgers, R., Ozanne, B., Fitzgerald, U., and Barnett, S. (2005) Role of Mayven, a Kelch-related protein in oligodendrocyte process formation. Journal of Neuroscience Research, 81 (5). pp. 622-631. ISSN 0360-4012 (doi:10.1002/jnr.20588)

2004

Barnett, S. (2004) Immunohistochemical studies of the cellular changes in the peripheral olfactory system after zinc sulfate nasal irrigation. Neurochemical Research, 29 (5). pp. 891-901.

Barnett, S. (2004) Olfactory ensheathing cells and CNS repair: going solo or in need of a friend? Trends in Neurosciences, 27 (1). pp. 54-60.

Barnett, S. (2004) Olfactory ensheathing cells: Unique glial cell types? Journal of Neurotrauma, 21 (4). pp. 375-382.

Barnett, S., and Riddell, J. (2004) Olfactory ensheathing cells (OECs) and the treatment of CNS injury: advantages and possible caveats. Journal of Anatomy, 204 . pp. 57-67.

Riddell, J., Enriquez-Denton, M., Toft, A., Fairless, R., and Barnett, S. (2004) Olfactory ensheathing cell grafts have minimal influence on regeneration at the dorsal root entry zone following rhizotomy. Glia, 47 . pp. 150-167. (doi:10.1002/glia.20041)

Williams, S., Franklin, R., and Barnett, S. (2004) Response of olfactory ensheathing cells to the degeneration and regeneration of the peripheral olfactory system and the involvement of the neuregulins. Journal of Comparative Neurology, 470 . pp. 50-62. (doi:10.1002/cne.11045)

2003

Lakatos, A., Barnett, S., and Franklin, R. (2003) Olfactory ensheathing cells induce less host astrocyte response and chondroitin sulphate proteoglycan expression than Schwann cells following transplantation into adult CNS white matter. Experimental Neurology, 184 . pp. 237-246. (doi:10.1016/S0014-4886(03)00270-X)

Lakatos, A., Smith, P., Barnett, S., and Franklin, R. (2003) Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells. Brain, 126 . pp. 598-609. (doi:10.1093/brain/awg055)

2002

Alexander, C., Fitzgerald, U., and Barnett, S. (2002) Identification of growth factors that promote long-term proliferation of olfactory ensheathing cells and modulate their antigenic phenotype. Glia, 37 . pp. 349-364. (doi:10.1002/glia.10044)

Smith, P., Lakatos, A., Barnett, S., Jeffery, N., and Franklin, R. (2002) Cryopreserved cells isolated from the adult canine olfactory bulb are capable of extensive remyelination following transplantation into the adult rat CNS. Experimental Neurology, 176 . pp. 402-406. (doi:10.1006/exnr.2002.7936)

2001

Barnett, S., Thompson, R., Lakatos, A., and Pitts, J. (2001) Gap junctional communication and connexin expression in cultured olfactory ensheathing cells. Journal of Neuroscience Research, 65 . pp. 520-528.

Smith, P., Sim, F., Barnett, S., and Franklin, R. (2001) SCIP/Oct-6, Krox-20, and desert hedgehog mRNA expression during CNS remyelination by transplanted olfactory ensheathing cells. Glia, 36 . pp. 342-353.

2000

Barnett, S. C., Alexander, C. L., Iwashita, Y., Gilson, J. M., Crowther, J., Clark, L., Dunn, L. T., Papanastassiou, V., Kennedy, P. G. E., and Franklin, R. J. M. (2000) Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons. Brain, 123 (8). pp. 1581-1588. ISSN 0006-8950 (doi:10.1093/brain/123.8.1581)

1996

McKie, E., MacLean, A., Lewis, A., Cruickshank, G., Rampling, R., Barnett, S., Kennedy, P., and Brown, S. (1996) Selective in vitro replication of herpes simplex virus type 1 (HSV-1) ICP34.5 null mutants in primary human CNS tumours - evaluation of a potentially effective clinical therapy. British Journal of Cancer, 74 (5). pp. 745-752. ISSN 0007-0920 (doi:10.1038/bjc.1996.431)

1993

Willison, H.J., Paterson, G., Veitch, J., Inglis, G., and Barnett, S.C. (1993) Peripheral neuropathy associated with monoclonal IgM anti-Pr2 cold agglutinins. Journal of Neurology, Neurosurgery and Psychiatry, 56 (11). pp. 1178-1183. ISSN 0022-3050 (doi:10.1136/jnnp.56.11.1178)

This list was generated on Fri Oct 24 15:08:49 2014 BST.
Jump to: Article
Number of items: 54.

Article

Donoghue, P. S., Sun, T., Gadegaard, N., Riehle, M. O., and Barnett, S. C. (2014) Development of a novel 3D culture system for screening features of a complex implantable device for CNS repair. Molecular Pharmaceutics, 11 (7). pp. 2143-2150. ISSN 1543-8384 (doi:10.1021/mp400526n)

Boomkamp, S. D., McGrath, M. A., Houslay, M. D., and Barnett, S. C. (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. British Journal of Pharmacology, 171 (9). pp. 2385-2398. ISSN 0007-1188 (doi:10.1111/bph.12588)

Ioannidou, K., Anderson, K. I., Strachan, D., Edgar, J. M., and Barnett, S. C. (2014) Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques. BMC Neuroscience, 15 (1). p. 59. ISSN 1471-2202 (doi:10.1186/1471-2202-15-59)

Toft, A., Tome, M., Barnett, S.C., and Riddell, J.S. (2013) A comparative study of glial and non-neural cell properties for transplant-mediated repair of the injured spinal cord. Glia, 61 (4). pp. 513-528. ISSN 0894-1491 (doi:10.1002/glia.22452)

Lindsay, S.L., Johnstone, S.A., Mountford, J.C., Sheikh, S., Allan, D.B., Clark, L., and Barnett, S.C. (2013) Human mesenchymal stem cells isolated from olfactory biopsies but not bone enhance CNS myelinationin vitro. Glia, 61 (3). pp. 368-382. ISSN 0894-1491 (doi:10.1002/glia.22440)

Donoghue, P.S., Lamond, R., Boomkamp, S.D., Tao, S., Gadegaard, N., Riehle, M.O., and Barnett, S.C. (2013) The development of a ε-polycaprolactone (PCL) scaffold for CNS repair. Tissue Engineering Part A, 19 (3). ISSN 1937-3341 (doi:10.1089/ten.TEA.2012.0382)

Barnett, S.C., and Linington, C. (2013) Myelination: do astrocytes play a role? Neuroscientist, 19 (5). pp. 442-450. ISSN 1073-8584 (doi:10.1177/1073858412465655)

Lamond, R., and Barnett, S.C. (2013) Schwann cells but not olfactory ensheathing cells inhibit CNS myelination via the secretion of connective tissue growth factor. Journal of Neuroscience, 33 (47). pp. 18686-18697. ISSN 0270-6474 (doi:10.1523/JNEUROSCI.3233-13.2013)

Moleirinho, S. et al. (2013) KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals. Oncogene, 32 (14). pp. 1821-1830. ISSN 0950-9232 (doi:10.1038/onc.2012.196)

Moleirinho, S., Patrick, C., Tilston-Lünel, A.M., Higginson, J.R., Angus, L., Antkowiak, M., Barnett, S.C., Prystowsky, M.B., Reynolds, P.A., and Gunn-Moore, F.J. (2013) Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts. PLoS ONE, 8 (4). e60028. ISSN 1932-6203 (doi:10.1371/journal.pone.0060028)

Sun, T., Donoghue, P.S., Higginson, J.R., Gadegaard, N., Barnett, S.C., and Riehle, M.O. (2013) A miniaturized bioreactor system for the evaluation of cell interaction with designed substrates in perfusion culture. Journal of Tissue Engineering and Regenerative Medicine, 6 (S3). S4-S14. ISSN 1932-6254 (doi:10.1002/term.510)

Higginson, J.R., Thompson, S.M., Santos-Silva, A., Guimond, S.E., Turnbull, J.E., and Barnett, S.C. (2012) Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation. Journal of Neuroscience, 32 (45). pp. 15902-15912. ISSN 0270-6474 (doi:10.1523/JNEUROSCI.6340-11.2012)

Sandvig, I. et al. (2012) In vivo MRI of olfactory ensheathing cell grafts and regenerating axons in transplant mediated repair of the adult rat optic nerve. NMR in Biomedicine, 25 (4). pp. 620-631. ISSN 0952-3480 (doi:10.1002/nbm.1778)

Toft, A., Tomé, M., Lindsay, S.L., Barnett, S.C., and Riddell, J.S. (2012) Transplant-mediated repair properties of rat olfactory mucosal OM-I and OM-II sphere-forming cells. Journal of Neuroscience Research, 90 (3). pp. 619-631. ISSN 0360-4012 (doi:10.1002/jnr.22789)

Boomkamp, S.D., Riehle, M.O., Wood, J., Olson, M.F., and Barnett, S.C. (2012) The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of rho and ROCK inhibitors on neurite outgrowth and myelination. Glia, 60 (3). pp. 441-456. ISSN 0894-1491 (doi:10.1002/glia.22278)

Elliott, C. et al. (2012) Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain, 135 (6). pp. 1819-1833. ISSN 0006-8950 (doi:10.1093/brain/aws105)

Ioannidou, K., Anderson, K.I., Strachan, D., Edgar, J.M., and Barnett, S.C. (2012) Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS ONE, 7 (1). e30775. ISSN 1932-6203 (doi:10.1371/journal.pone.0030775)

Sandvig, I., Hoang, L., Sardella, T.C.P., Barnett, S.C., Brekken, C., Tvedt, K., Berry, M., Haraldseth, O., Sandvig, A., and Thuen, M. (2012) Labelling of olfactory ensheathing cells with micron-sized particles of iron oxide and detection by MRI. Contrast Media and Molecular Imaging, 7 (4). pp. 403-410. ISSN 1555-4309 (doi:10.1002/cmmi.1465)

Nash, B., Thomson, C.E., Linington, C., Arthur, A.T., McClure, J.D., McBride, M.W., and Barnett, S.C. (2011) Functional duality of astrocytes in myelination. Journal of Neuroscience, 31 (37). pp. 13028-13038. ISSN 0270-6474 (doi:10.1523/JNEUROSCI.1449-11.2011)

Sun, T., Donoghue, P.S., Higginson, J.R., Gadegaard, N., Barnett, S.C., and Riehle, M.O. (2011) The interactions of astrocytes and fibroblasts with defined pore structures in static and perfusion cultures. Biomaterials, 32 (8). pp. 2021-2031. ISSN 0142-9612 (doi:10.1016/j.biomaterials.2010.11.046)

Brennan, K.M. et al. (2011) Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. Journal of Neuroimmunology, 238 (1-2). pp. 87-95. ISSN 0165-5728 (doi:10.1016/j.jneuroim.2011.08.002)

Higginson, J.R., and Barnett, S.C. (2011) The culture of olfactory ensheathing cells (OECs)—a distinct glial cell type. Experimental Neurology, 229 (1). pp. 2-9. ISSN 0014-4886 (doi:10.1016/j.expneurol.2010.08.020)

Lindsay, S.L., Riddell, J.S., and Barnett, S.C. (2010) Olfactory mucosa for transplant-mediated repair: a complex tissue for a complex injury? Glia, 58 (2). pp. 125-134. ISSN 0894-1491 (doi:10.1002/glia.20917)

Montague, P., Kennedy, P.G.E., and Barnett, S.C. (2010) Subcellular localization of Mayven following expression of wild type and mutant EGFP tagged cDNAs. BMC Neuroscience, 11 (1). p. 63. ISSN 1471-2202 (doi:10.1186/1471-2202-11-63)

Nash, B., Ioannidou, K., and Barnett, S.C. (2010) Astrocyte phenotypes and their relationship to myelination. Journal of Anatomy, 219 (1). pp. 44-52. ISSN 0021-8782 (doi:10.1111/j.1469-7580.2010.01330.x)

Tome, M., Lindsay, S. L., Riddell, J. S., and Barnett, S. C. (2009) Identification of nonepithelial multipotent cells in the embryonic olfactory mucosa. Stem Cells, 27 (9). pp. 2196-2208. ISSN 1066-5099 (doi:10.1002/stem.130)

Eisenbach, M., Kartvelishvily, E., Eshed-Eisenbach, Y., Watkins, T., Sorensen, A., Thomson, C., Ranscht, B., Barnett, S., Brophy, P., and Peles, E. (2009) Differential Clustering of Caspr by Oligodendrocytes and Schwann Cells. Journal of Neuroscience Research, 87 (15). pp. 3492-3501. ISSN 0360-4012 (doi:10.1002/jnr.22157 )

Lamond, R., Donoghue, P., Gadegaard, N., Riehle, M., and Barnett, S. (2009) Developing a biodegradable construct to enhance axonal alignment following a spinal cord injury. Glia, 57 (13). S162-S162. ISSN 0894-1491

Silajdzic, E., Willison, H., Furukawa, K., and Barnett, S. (2009) In Vitro Analysis of Glial Cell Function in Ganglioside-deficient Mice. Journal of Neuroscience Research, 87 (11). pp. 2467-2483. ISSN 0360-4012 (doi:10.1002/jnr.22085 )

Thomson, C.E., McCulloch, M., Sorenson, A., Barnett, S.C., Seed, B.V., Griffiths, I.R., and McLaughlin, M. (2008) Myelinated, synapsing cultures of murine spinal cord - validation as an in vitro model of the central nervous system. European Journal of Neuroscience, 28 (8). pp. 1518-1535. ISSN 0953-816X (doi:10.1111/j.1460-9568.2008.06415.x)

Sorensen, A., Moffat, K., Thomson, C., and Barnett, S. (2008) Astrocytes, but not olfactory ensheathing cells or Schwann cells, promote myelination of CNS axons in vitro. Glia, 56 (7). pp. 750-763. ISSN 0894-1491 (doi:10.1002/glia.20650 )

Tomé, M., Siladžic, E., Santos-Silva, A., and Barnett, S. C. (2007) Calponin is expressed by subpopulations of connective tissue cells but not olfactory ensheathing cells in the neonatal olfactory mucosa. BMC Neuroscience, 8 (74). ISSN 1471-2202 (doi:10.1186/1471-2202-8-74)

Santos-Silva, A., Fairless, R., Frame, M.C., Montague, P., Smith, G.M., Toft, A., Riddell, J.S., and Barnett, S.C. (2007) FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis. Journal of Neuroscience, 27 (27). pp. 7154-7167. ISSN 0270-6474 (doi:10.1523/JNEUROSCI.1184-07.2007)

Barnett, S., and Riddell, J. (2007) Olfactory ensheathing cell transplantation as a strategy for spinal cord repair - what can it achieve? Nature Clinical Practice Neurology, 3 . pp. 152-161. (doi:10.1038/ncpneuro0447)

Dewar, D., Bentley, D., and Barnett, S. (2007) Implantation of pure cultured olfactory ensheathing cells in an animal model of parkinsonism. Acta Neurochirurgica, 149 . pp. 407-414. (doi:10.1007/s00701-007-1121-5)

Toft, A., Scott, D., Barnett, S., and Riddell, J. (2007) Electrophysiological evidence that olfactory cell transplants improve function after spinal cord injury. Brain, 130 . pp. 970-984. (doi:10.1093/brain/awm040)

Fairless, R., and Barnett, S. (2005) Olfactory ensheathing cells: their role in central nervous system repair. International Journal of Biochemistry and Cell Biology, 37 . pp. 693-699. (doi:10.1016/j.biocel.2004.10.010)

Fairless, R., Frame, M., and Barnett, S. (2005) N-cadherin differentially determines Schwann cell and olfactory ensheathing cell adhesion and migration responses upon contact with astrocytes. Molecular and Cellular Neuroscience, 28 . pp. 253-263. (doi:10.1016/j.mcn.2004.09.009)

Williams, S., Spence, H., Rodgers, R., Ozanne, B., Fitzgerald, U., and Barnett, S. (2005) Role of Mayven, a Kelch-related protein in oligodendrocyte process formation. Journal of Neuroscience Research, 81 (5). pp. 622-631. ISSN 0360-4012 (doi:10.1002/jnr.20588)

Barnett, S. (2004) Immunohistochemical studies of the cellular changes in the peripheral olfactory system after zinc sulfate nasal irrigation. Neurochemical Research, 29 (5). pp. 891-901.

Barnett, S. (2004) Olfactory ensheathing cells and CNS repair: going solo or in need of a friend? Trends in Neurosciences, 27 (1). pp. 54-60.

Barnett, S. (2004) Olfactory ensheathing cells: Unique glial cell types? Journal of Neurotrauma, 21 (4). pp. 375-382.

Barnett, S., and Riddell, J. (2004) Olfactory ensheathing cells (OECs) and the treatment of CNS injury: advantages and possible caveats. Journal of Anatomy, 204 . pp. 57-67.

Riddell, J., Enriquez-Denton, M., Toft, A., Fairless, R., and Barnett, S. (2004) Olfactory ensheathing cell grafts have minimal influence on regeneration at the dorsal root entry zone following rhizotomy. Glia, 47 . pp. 150-167. (doi:10.1002/glia.20041)

Williams, S., Franklin, R., and Barnett, S. (2004) Response of olfactory ensheathing cells to the degeneration and regeneration of the peripheral olfactory system and the involvement of the neuregulins. Journal of Comparative Neurology, 470 . pp. 50-62. (doi:10.1002/cne.11045)

Lakatos, A., Barnett, S., and Franklin, R. (2003) Olfactory ensheathing cells induce less host astrocyte response and chondroitin sulphate proteoglycan expression than Schwann cells following transplantation into adult CNS white matter. Experimental Neurology, 184 . pp. 237-246. (doi:10.1016/S0014-4886(03)00270-X)

Lakatos, A., Smith, P., Barnett, S., and Franklin, R. (2003) Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells. Brain, 126 . pp. 598-609. (doi:10.1093/brain/awg055)

Alexander, C., Fitzgerald, U., and Barnett, S. (2002) Identification of growth factors that promote long-term proliferation of olfactory ensheathing cells and modulate their antigenic phenotype. Glia, 37 . pp. 349-364. (doi:10.1002/glia.10044)

Smith, P., Lakatos, A., Barnett, S., Jeffery, N., and Franklin, R. (2002) Cryopreserved cells isolated from the adult canine olfactory bulb are capable of extensive remyelination following transplantation into the adult rat CNS. Experimental Neurology, 176 . pp. 402-406. (doi:10.1006/exnr.2002.7936)

Barnett, S., Thompson, R., Lakatos, A., and Pitts, J. (2001) Gap junctional communication and connexin expression in cultured olfactory ensheathing cells. Journal of Neuroscience Research, 65 . pp. 520-528.

Smith, P., Sim, F., Barnett, S., and Franklin, R. (2001) SCIP/Oct-6, Krox-20, and desert hedgehog mRNA expression during CNS remyelination by transplanted olfactory ensheathing cells. Glia, 36 . pp. 342-353.

Barnett, S. C., Alexander, C. L., Iwashita, Y., Gilson, J. M., Crowther, J., Clark, L., Dunn, L. T., Papanastassiou, V., Kennedy, P. G. E., and Franklin, R. J. M. (2000) Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons. Brain, 123 (8). pp. 1581-1588. ISSN 0006-8950 (doi:10.1093/brain/123.8.1581)

McKie, E., MacLean, A., Lewis, A., Cruickshank, G., Rampling, R., Barnett, S., Kennedy, P., and Brown, S. (1996) Selective in vitro replication of herpes simplex virus type 1 (HSV-1) ICP34.5 null mutants in primary human CNS tumours - evaluation of a potentially effective clinical therapy. British Journal of Cancer, 74 (5). pp. 745-752. ISSN 0007-0920 (doi:10.1038/bjc.1996.431)

Willison, H.J., Paterson, G., Veitch, J., Inglis, G., and Barnett, S.C. (1993) Peripheral neuropathy associated with monoclonal IgM anti-Pr2 cold agglutinins. Journal of Neurology, Neurosurgery and Psychiatry, 56 (11). pp. 1178-1183. ISSN 0022-3050 (doi:10.1136/jnnp.56.11.1178)

This list was generated on Fri Oct 24 15:08:49 2014 BST.