Professor Steven Sinkins

  • Professor in Microbiology and Tropical Medicine (Centre for Virus Research)

telephone: 0141 3302876
email: Steven.Sinkins@glasgow.ac.uk

Research interests

CVR Logo 1

Mosquitoes transmit some of the world’s most serious infections; epidemic viral diseases such as dengue impose huge health burdens across the tropics. Effective vaccines are not available for most mosquito-borne pathogens, and control of the mosquito vectors has long been a focus of disease prevention.

Wolbachia are inherited intracellular bacteria that can manipulate host insect reproduction, especially by inducing patterns of sterility known as cytoplasmic incompatibility, allowing population invasion. It occurs naturally in many mosquito species, and certain introduced strains have been found to strongly inhibit the transmission of mosquito-borne viruses such as dengue and Zika.

We are interested in how this inhibition occurs, how it can be used in disease control, and how Wolbachia manipulate their hosts.


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Wolbachia-mediated arbovirus inhibition in mosquitoes
    Wellcome Trust
    2016 - 2021
     
  • Wolbachia-based control of virus transmission by the mosquito Aedes albopictus
    Wellcome Trust
    2016 - 2021
     
  • ZIKA: Vector competence and interactions with Wolbachia
    Medical Research Council
    2016 - 2017
     

Publications

List by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004
Number of items: 27.

2016

Sinkins, S. P. (2016) Yob makes mosquitoes male. Science, 353(6294), pp. 33-34. (doi:10.1126/science.aag1012) (PMID:27365441)

Molloy, J. C., Sommer, U., Viant, M. R. and Sinkins, S. P. (2016) Wolbachia modulates lipid metabolism in Aedes albopictus mosquito cells. Applied and Environmental Microbiology, 82(10), pp. 3109-3120. (doi:10.1128/AEM.00275-16) (PMID:26994075) (PMCID:PMC4959074)

2015

Molloy, J. c. and Sinkins, S. P. (2015) Wolbachia do not induce reactive oxygen species-dependent immune pathway activation in Aedes albopictus. Viruses, 7(8), pp. 4624-4639. (doi:10.3390/v7082836) (PMID:26287231) (PMCID:PMC4576197)

2014

Sutton, E. R., Harris, S. R., Parkhill, J. and Sinkins, S. P. (2014) Comparative genome analysis of Wolbachia strain wAu. BMC Genomics, 15, 928. (doi:10.1186/1471-2164-15-928) (PMID:25341639) (PMCID:PMC4223829)

Hapairai, L. K., Marie, J., Sinkins, S. P. and Bossin, H. C. (2014) Effect of temperature and larval density on Aedes polynesiensis (Diptera: Culicidae) laboratory rearing productivity and male characteristics. Acta Tropica, 132(Suppl), S108-S115. (doi:10.1016/j.actatropica.2013.11.024) (PMID:24316237)

2013

Pinto, S. B., Stainton, K., Harris, S., Kambris, Z., Sutton, E. R., Bonsall, M. B., Parkhill, J. and Sinkins, S. P. (2013) Transcriptional regulation of culex pipiens mosquitoes by wolbachia influences cytoplasmic incompatibility. PLoS Pathogens, 9(10), e1003647. (doi:10.1371/journal.ppat.1003647) (PMID:24204251) (PMCID:PMC3814344)

Sinkins, S. P. (2013) Wolbachia and arbovirus inhibition in mosquitoes. Future Microbiology, 8(10), pp. 1249-1256. (doi:10.2217/fmb.13.95) (PMID:24059916)

Hapairai, L. K., Sang, M. A. C., Sinkins, S. P. and Bossin, H. C. (2013) Population studies of the filarial vector Aedes polynesiensis (Diptera: Culicidae) in two island settings of French Polynesia. Journal of Medical Entomology, 50(5), pp. 965-976. (doi:10.1603/ME12246) (PMID:24180100)

Hapairai, L. K., Joseph, H., Sang, M. A. C., Melrose, W., Ritchie, S. A., Burkot, T. R., Sinkins, S. P. and Bossin, H. C. (2013) Field evaluation of selected traps and lures for monitoring the filarial and arbovirus vector, Aedes polynesiensis (Diptera: Culicidae), in French Polynesia. Journal of Medical Entomology, 50(4), pp. 731-739. (doi:10.1603/ME12270) (PMID:23926770)

Blagrove, M. S.C., Arias-Goeta, C., Di Genua, C., Failloux, A.-B. and Sinkins, S. P. (2013) A Wolbachia wMel transinfection in Aedes albopictus is not detrimental to host fitness and inhibits Chikungunya virus. PLoS Neglected Tropical Diseases, 7(3), e2152. (doi:10.1371/journal.pntd.0002152) (PMID:23556030) (PMCID:PMC3610642)

2012

Pinto, S. B., Mariconti, M., Bazzocchi, C., Bandi, C. and Sinkins, S. P. (2012) Wolbachia surface protein induces innate immune responses in mosquito cells. BMC Microbiology, 12(Suppl), S11. (doi:10.1186/1471-2180-12-S1-S11) (PMID:22375833) (PMCID:PMC3287508)

Blagrove, M. S.C., Arias-Goeta, C., Failloux, A.-B. and Sinkins, S. P. (2012) Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus. Proceedings of the National Academy of Sciences of the United States of America, 109(1), pp. 255-260. (doi:10.1073/pnas.1112021108) (PMID:22123944) (PMCID:PMC3252941)

2011

Sinkins, S. P. (2011) Invertebrate post-segregation distorters: a new embryo-killing gene. PLoS Biology, 9(7), e1001114. (doi:10.1371/journal.pbio.1001114) (PMID:21814492) (PMCID:PMC3144190)

Hancock, P. A., Sinkins, S. P. and Godfray, H. C. J. (2011) Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases. PLoS Neglected Tropical Diseases, 5(4), e1024. (doi:10.1371/journal.pntd.0001024) (PMID:21541357) (PMCID:PMC3082501)

Hancock, P. A., Sinkins, S. P. and Godfray, H. C. J. (2011) Population dynamic models of the spread of Wolbachia. American Naturalist, 177(3), pp. 323-333. (doi:10.1086/658121) (PMID:21460541)

2010

Kambris, Z., Blagborough, A. M., Pinto, S. B., Blagrove, M. S.C., Godfray, H. C. J., Sinden, R. E. and Sinkins, S. P. (2010) Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae. PLoS Pathogens, 6(10), e1001143. (doi:10.1371/journal.ppat.1001143) (PMID:20949079) (PMCID:PMC2951381)

2009

Kambris, Z., Cook, P. E., Phuc, H. K. and Sinkins, S. P. (2009) Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. Science, 326(5949), pp. 134-136. (doi:10.1126/science.1177531) (PMID:19797660) (PMCID:PMC2867033)

Walker, T., Song, S. and Sinkins, S. P. (2009) Wolbachia in the Culex pipiens group mosquitoes: introgression and superinfection. Journal of Heredity, 100(2), pp. 192-196. (doi:10.1093/jhered/esn079) (PMID:18836146) (PMCID:PMC2726571)

Klasson, L., Kambris, Z., Cook, P. E., Walker, T. and Sinkins, S. P. (2009) Horizontal gene transfer between Wolbachia and the mosquito Aedes aegypti. BMC Genomics, 10, 33. (doi:10.1186/1471-2164-10-33) (PMID:19154594) (PMCID:PMC2647948)

2008

Klasson, L. et al. (2008) Genome evolution of Wolbachia strain wPip from the Culex pipiens group. Molecular Biology and Evolution, 25(9), pp. 1877-1887. (doi:10.1093/molbev/msn133) (PMID:18550617) (PMCID:PMC2515876)

2007

Walker, T., Klasson, L., Sebaihia, M., Sanders, M. J., Thomson, N. R., Parkhill, J. and Sinkins, S. P. (2007) Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens group. BMC Biology, 5, 39. (doi:10.1186/1741-7007-5-39) (PMID:17883830) (PMCID:PMC2045654)

Nene, V. et al. (2007) Genome sequence of Aedes aegypti, a major arbovirus vector. Science, 316(5832), pp. 1718-1723. (doi:10.1126/science.1138878) (PMID:17510324) (PMCID:PMC2868357)

2006

Sinkins, S. P. and Gould, F. (2006) Gene drive systems for insect disease vectors. Nature Reviews Genetics, 7(6), pp. 427-435. (doi:10.1038/nrg1870) (PMID:16682981)

2005

Sinkins, S. P., Walker, T., Lynd, A. R., Steven, A. R., Makepeace, B. L., Godfray, H. C. J. and Parkhill, J. (2005) Wolbachia variability and host effects on crossing type in Culex mosquitoes. Nature, 436(7048), pp. 257-260. (doi:10.1038/nature03629) (PMID:16015330)

2004

Sinkins, S. P. and Hastings, I. M. (2004) Male-specific insecticide resistance and mosquito transgene dispersal. Trends in Parasitology, 20(9), pp. 413-416. (doi:10.1016/j.pt.2004.07.003) (PMID:15324731)

Sinkins, S. P. and Godfray, H. C. J. (2004) Use of Wolbachia to drive nuclear transgenes through insect populations. Proceedings of the Royal Society of London Series B: Biological Sciences, 271(1546), pp. 1421-1426. (doi:10.1098/rspb.2004.2740) (PMID:15306342) (PMCID:PMC1691734)

Sinkins, S. P. (2004) Wolbachia and cytoplasmic incompatibility in mosquitoes. Insect Biochemistry and Molecular Biology, 34(7), pp. 723-729. (doi:10.1016/j.ibmb.2004.03.025) (PMID:15242714)

This list was generated on Sun Jun 25 05:17:43 2017 BST.
Jump to: Articles
Number of items: 27.

Articles

Sinkins, S. P. (2016) Yob makes mosquitoes male. Science, 353(6294), pp. 33-34. (doi:10.1126/science.aag1012) (PMID:27365441)

Molloy, J. C., Sommer, U., Viant, M. R. and Sinkins, S. P. (2016) Wolbachia modulates lipid metabolism in Aedes albopictus mosquito cells. Applied and Environmental Microbiology, 82(10), pp. 3109-3120. (doi:10.1128/AEM.00275-16) (PMID:26994075) (PMCID:PMC4959074)

Molloy, J. c. and Sinkins, S. P. (2015) Wolbachia do not induce reactive oxygen species-dependent immune pathway activation in Aedes albopictus. Viruses, 7(8), pp. 4624-4639. (doi:10.3390/v7082836) (PMID:26287231) (PMCID:PMC4576197)

Sutton, E. R., Harris, S. R., Parkhill, J. and Sinkins, S. P. (2014) Comparative genome analysis of Wolbachia strain wAu. BMC Genomics, 15, 928. (doi:10.1186/1471-2164-15-928) (PMID:25341639) (PMCID:PMC4223829)

Hapairai, L. K., Marie, J., Sinkins, S. P. and Bossin, H. C. (2014) Effect of temperature and larval density on Aedes polynesiensis (Diptera: Culicidae) laboratory rearing productivity and male characteristics. Acta Tropica, 132(Suppl), S108-S115. (doi:10.1016/j.actatropica.2013.11.024) (PMID:24316237)

Pinto, S. B., Stainton, K., Harris, S., Kambris, Z., Sutton, E. R., Bonsall, M. B., Parkhill, J. and Sinkins, S. P. (2013) Transcriptional regulation of culex pipiens mosquitoes by wolbachia influences cytoplasmic incompatibility. PLoS Pathogens, 9(10), e1003647. (doi:10.1371/journal.ppat.1003647) (PMID:24204251) (PMCID:PMC3814344)

Sinkins, S. P. (2013) Wolbachia and arbovirus inhibition in mosquitoes. Future Microbiology, 8(10), pp. 1249-1256. (doi:10.2217/fmb.13.95) (PMID:24059916)

Hapairai, L. K., Sang, M. A. C., Sinkins, S. P. and Bossin, H. C. (2013) Population studies of the filarial vector Aedes polynesiensis (Diptera: Culicidae) in two island settings of French Polynesia. Journal of Medical Entomology, 50(5), pp. 965-976. (doi:10.1603/ME12246) (PMID:24180100)

Hapairai, L. K., Joseph, H., Sang, M. A. C., Melrose, W., Ritchie, S. A., Burkot, T. R., Sinkins, S. P. and Bossin, H. C. (2013) Field evaluation of selected traps and lures for monitoring the filarial and arbovirus vector, Aedes polynesiensis (Diptera: Culicidae), in French Polynesia. Journal of Medical Entomology, 50(4), pp. 731-739. (doi:10.1603/ME12270) (PMID:23926770)

Blagrove, M. S.C., Arias-Goeta, C., Di Genua, C., Failloux, A.-B. and Sinkins, S. P. (2013) A Wolbachia wMel transinfection in Aedes albopictus is not detrimental to host fitness and inhibits Chikungunya virus. PLoS Neglected Tropical Diseases, 7(3), e2152. (doi:10.1371/journal.pntd.0002152) (PMID:23556030) (PMCID:PMC3610642)

Pinto, S. B., Mariconti, M., Bazzocchi, C., Bandi, C. and Sinkins, S. P. (2012) Wolbachia surface protein induces innate immune responses in mosquito cells. BMC Microbiology, 12(Suppl), S11. (doi:10.1186/1471-2180-12-S1-S11) (PMID:22375833) (PMCID:PMC3287508)

Blagrove, M. S.C., Arias-Goeta, C., Failloux, A.-B. and Sinkins, S. P. (2012) Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus. Proceedings of the National Academy of Sciences of the United States of America, 109(1), pp. 255-260. (doi:10.1073/pnas.1112021108) (PMID:22123944) (PMCID:PMC3252941)

Sinkins, S. P. (2011) Invertebrate post-segregation distorters: a new embryo-killing gene. PLoS Biology, 9(7), e1001114. (doi:10.1371/journal.pbio.1001114) (PMID:21814492) (PMCID:PMC3144190)

Hancock, P. A., Sinkins, S. P. and Godfray, H. C. J. (2011) Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases. PLoS Neglected Tropical Diseases, 5(4), e1024. (doi:10.1371/journal.pntd.0001024) (PMID:21541357) (PMCID:PMC3082501)

Hancock, P. A., Sinkins, S. P. and Godfray, H. C. J. (2011) Population dynamic models of the spread of Wolbachia. American Naturalist, 177(3), pp. 323-333. (doi:10.1086/658121) (PMID:21460541)

Kambris, Z., Blagborough, A. M., Pinto, S. B., Blagrove, M. S.C., Godfray, H. C. J., Sinden, R. E. and Sinkins, S. P. (2010) Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae. PLoS Pathogens, 6(10), e1001143. (doi:10.1371/journal.ppat.1001143) (PMID:20949079) (PMCID:PMC2951381)

Kambris, Z., Cook, P. E., Phuc, H. K. and Sinkins, S. P. (2009) Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. Science, 326(5949), pp. 134-136. (doi:10.1126/science.1177531) (PMID:19797660) (PMCID:PMC2867033)

Walker, T., Song, S. and Sinkins, S. P. (2009) Wolbachia in the Culex pipiens group mosquitoes: introgression and superinfection. Journal of Heredity, 100(2), pp. 192-196. (doi:10.1093/jhered/esn079) (PMID:18836146) (PMCID:PMC2726571)

Klasson, L., Kambris, Z., Cook, P. E., Walker, T. and Sinkins, S. P. (2009) Horizontal gene transfer between Wolbachia and the mosquito Aedes aegypti. BMC Genomics, 10, 33. (doi:10.1186/1471-2164-10-33) (PMID:19154594) (PMCID:PMC2647948)

Klasson, L. et al. (2008) Genome evolution of Wolbachia strain wPip from the Culex pipiens group. Molecular Biology and Evolution, 25(9), pp. 1877-1887. (doi:10.1093/molbev/msn133) (PMID:18550617) (PMCID:PMC2515876)

Walker, T., Klasson, L., Sebaihia, M., Sanders, M. J., Thomson, N. R., Parkhill, J. and Sinkins, S. P. (2007) Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens group. BMC Biology, 5, 39. (doi:10.1186/1741-7007-5-39) (PMID:17883830) (PMCID:PMC2045654)

Nene, V. et al. (2007) Genome sequence of Aedes aegypti, a major arbovirus vector. Science, 316(5832), pp. 1718-1723. (doi:10.1126/science.1138878) (PMID:17510324) (PMCID:PMC2868357)

Sinkins, S. P. and Gould, F. (2006) Gene drive systems for insect disease vectors. Nature Reviews Genetics, 7(6), pp. 427-435. (doi:10.1038/nrg1870) (PMID:16682981)

Sinkins, S. P., Walker, T., Lynd, A. R., Steven, A. R., Makepeace, B. L., Godfray, H. C. J. and Parkhill, J. (2005) Wolbachia variability and host effects on crossing type in Culex mosquitoes. Nature, 436(7048), pp. 257-260. (doi:10.1038/nature03629) (PMID:16015330)

Sinkins, S. P. and Hastings, I. M. (2004) Male-specific insecticide resistance and mosquito transgene dispersal. Trends in Parasitology, 20(9), pp. 413-416. (doi:10.1016/j.pt.2004.07.003) (PMID:15324731)

Sinkins, S. P. and Godfray, H. C. J. (2004) Use of Wolbachia to drive nuclear transgenes through insect populations. Proceedings of the Royal Society of London Series B: Biological Sciences, 271(1546), pp. 1421-1426. (doi:10.1098/rspb.2004.2740) (PMID:15306342) (PMCID:PMC1691734)

Sinkins, S. P. (2004) Wolbachia and cytoplasmic incompatibility in mosquitoes. Insect Biochemistry and Molecular Biology, 34(7), pp. 723-729. (doi:10.1016/j.ibmb.2004.03.025) (PMID:15242714)

This list was generated on Sun Jun 25 05:17:43 2017 BST.

Visit the  Sinkins Group webpage