Professor Sam Wilson
- Affiliate (School of Infection & Immunity)
email:
Sam.Wilson@glasgow.ac.uk
Cambridge Institute of Therapeutic Immunol & Infect Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Puddicombe Way, CB2 0AW
https://orcid.org/0000-0002-6065-0895Research interests
The ‘antiviral state’ induced by interferons attenuates the replication of most, if not all, mammalian viruses. Upon sensing a pathogen, interferon signaling results in the upregulation of hundreds of different genes. These interferon stimulated genes (ISGs) are able to mediate further signaling, modulate the cellular environment, or interfere with viruses directly, in order to impede viral replication. Despite intensive investigation, the exact contribution of individual ISGs to the antiviral state is often unknown. However, in some remarkable cases individual ISGs have been described that effectively render cells resistant to certain viruses. The extraordinary ability of these factors to restrict virus replication can protect individuals, populations and entire species from specific pathogens.
It is my belief that many restriction factors remain unidentified because evolution has rendered viruses supremely adept at avoiding and disabling the arsenal of intrinsic immune effectors within the host cell. My lab is focused on identifying and characterising these novel intrinsic immune factors. We mainly investigate a diverse range of retroviruses where multiple antiretroviral ISGs, such as APOBEC3G, TRIM5, tetherin and SAMHD1 have redefined our understanding of species-specific restriction. Based on this experience we utilize both human and rhesus macaque ISG-expression libraries to investigate retroviral replication. We are also diversifying our approach and applying medium- throughput ISG expression screening to an expanding array of virus families.
Our long-term goal is to harness the information gleaned from characterising host-viral interactions to identify novel therapeutic targets and develop biotechnologies, based upon intrinsic immune factors, that could reduce the disease burden in human or livestock populations.
Publications
2023
Lytras, S. et al. (2023) Resurrection of 2′-5′-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication. PLoS Biology, 21(11), e3002398. (doi: 10.1371/journal.pbio.3002398) (PMID:38015855)
Pinto, R. M. et al. (2023) BTN3A3 evasion promotes the zoonotic potential of influenza A viruses. Nature, 619(7969), pp. 338-347. (doi: 10.1038/s41586-023-06261-8) (PMID:37380775)
Hardy, A. et al. (2023) The timing and magnitude of the type I interferon response are correlated with disease tolerance in arbovirus infection. mBio, 14(3), e0010123. (doi: 10.1128/mbio.00101-23) (PMID:37097030) (PMCID:PMC10294695)
2022
Sugrue, E. et al. (2022) The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness. PLoS Pathogens, 18(11), e1010973. (doi: 10.1371/journal.ppat.1010973) (PMID:36399512) (PMCID:PMC9718408)
Crozier, T. W.M. et al. (2022) Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion. Wellcome Open Research, 7, 224. (doi: 10.12688/wellcomeopenres.17946.1) (PMID:36483314) (PMCID:PMC9706147)
Bamford, C. G.C., Aranday-Cortes, E. , Sanchez-Velazquez, R., Mullan, C., Kohl, A. , Patel, A. H. , Wilson, S. J. and McLauchlan, J. (2022) A human and rhesus macaque interferon-stimulated gene screen shows that over-expression of ARHGEF3/XPLN inhibits replication of hepatitis C virus and other flavivirids. Viruses, 14(8), 1655. (doi: 10.3390/v14081655) (PMID:36016278) (PMCID:PMC9414520)
Fielding, C. A. et al. (2022) SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife, 11, e74489. (doi: 10.7554/elife.74489) (PMID:35587364) (PMCID:PMC9239683)
Galão, R. P., Wilson, H., Schierhorn, K. L., Debeljak, F., Bodmer, B. S., Goldhill, D., Hoenen, T., Wilson, S. J. , Swanson, C. M. and Neil, S. J. D. (2022) TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction. PLoS Pathogens, 18(5), e1010530. (doi: 10.1371/journal.ppat.1010530) (PMID:35533151) (PMCID:PMC9119685)
2021
Wickenhagen, A. et al. (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science, 374(6567), eabj3624. (doi: 10.1126/science.abj3624) (PMID:34581622)
Shaw, A. E. et al. (2021) The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. PLoS Biology, 19(9), e3001352. (doi: 10.1371/journal.pbio.3001352) (PMID:34491982) (PMCID:PMC8423302)
Szemiel, A. M. et al. (2021) In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2. PLoS Pathogens, 17(9), e1009929. (doi: 10.1371/journal.ppat.1009929) (PMID:34534263) (PMCID:PMC8496873)
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
Ruddell, S., Sugrue, E. , Memarzadeh, S., Hellam, L. M., Wilson, S. and France, D. (2021) Synthesis, enantiomeric resolution and biological evaluation of HIV capsid inhibition activity for racemic, (S)- and (R)-PF74. Molecules, 26(13), 3919. (doi: 10.3390/molecules26133919) (PMID:34206893) (PMCID:PMC8272108)
2020
Lin, Y.-T., Chiweshe, S., McCormick, D., Raper, A., Wickenhagen, A., DeFillipis, V., Gaunt, E., Simmonds, P., Wilson, S. J. and Grey, F. (2020) Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early 1 gene. PLoS Pathogens, 16(9), e1008844. (doi: 10.1371/journal.ppat.1008844) (PMID:32886716) (PMCID:PMC7498042)
2019
Rihn, S. J. et al. (2019) TRIM69 inhibits vesicular stomatitis Indiana virus (VSIV). Journal of Virology, 93(20), e00951-19. (doi: 10.1128/JVI.00951-19) (PMID:31375575)
Dennis, T. P.W., Souza, W. M. d., Marsile-Medun, S., Singer, J. B., Wilson, S. J. and Gifford, R. J. (2019) The evolution, distribution and diversity of endogenous circoviral elements in vertebrate genomes. Virus Research, 262, pp. 15-23. (doi: 10.1016/j.virusres.2018.03.014) (PMID:29601845) (PMCID:PMC6372831)
2018
Dennis, T. P.W., Flynn, P. J., Souza, W. M. d., Singer, J. B., Moreau, C. S., Wilson, S. J. and Gifford, R. J. (2018) Insights into circovirus host range from the genomic fossil record. Journal of Virology, 92(16), e00145-18. (doi: 10.1128/JVI.00145-18) (PMID:29875243) (PMCID:PMC6069186)
Feng, J. et al. (2018) Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20. Journal of Virology, 92(13), e02140-17. (doi: 10.1128/JVI.02140-17) (PMID:29695422) (PMCID:PMC6002717)
2017
Shaw, A. E. et al. (2017) Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses. PLoS Biology, 15(12), e2004086. (doi: 10.1371/journal.pbio.2004086) (PMID:29253856) (PMCID:PMC574750)
Rihn, S. J. , Foster, T. L., Busnadiego, I., Aziz, M. A. B., Hughes, J. , Neil, S. J.D. and Wilson, S. J. (2017) The envelope gene of transmitted HIV-1 resists a late interferon gamma-induced block. Journal of Virology, 91(7), e02254-16. (doi: 10.1128/JVI.02254-16) (PMID:28100611) (PMCID:PMC5355616)
Terry, A., Kilbey, A., Naseer, A., Levy, L. S., Ahmad, S., Watts, C., Mackay, N., Cameron, E. , Wilson, S. and Neil, J. C. (2017) Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis. Journal of Virology, 91(5), e02119-16. (doi: 10.1128/JVI.02119-16) (PMID:28031367) (PMCID:PMC5309941)
2016
Kane, M., Zang, T. M., Rihn, S. J. , Zhang, F., Kueck, T., Alim, M., Schoggins, J., Rice, C. M., Wilson, S. J. and Bieniasz, P. D. (2016) Identification of interferon-stimulated genes with antiretroviral activity. Cell Host and Microbe, 20(3), pp. 392-405. (doi: 10.1016/j.chom.2016.08.005) (PMID:27631702) (PMCID:PMC5026698)
2015
Dittmann, M. et al. (2015) A Serpin shapes the extracellular environment to prevent influenza A virus maturation. Cell, 160(4), pp. 631-643. (doi: 10.1016/j.cell.2015.01.040) (PMID:25679759) (PMCID:PMC4328142)
Rihn, S. J. , Hughes, J. , Wilson, S. J. and Bieniasz, P. D. (2015) Uneven genetic robustness of HIV-1 integrase. Journal of Virology, 89(1), pp. 552-567. (doi: 10.1128/JVI.02451-14)
2014
Busnadiego, I. et al. (2014) Host and viral determinants of Mx2 antiretroviral activity. Journal of Virology, 88(14), pp. 7738-7752. (doi: 10.1128/JVI.00214-14) (PMID:24760893) (PMCID:PMC4097781)
2013
Kane, M. et al. (2013) MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature, 502(7472), pp. 563-566. (doi: 10.1038/nature12653)
Soll, S. J., Wilson, S. J. , Kutluay, S. B., Hatziioannou, T. and Bieniasz, P. D. (2013) Assisted evolution enables HIV-1 to overcome a high trim5α-imposed genetic barrier to rhesus macaque tropism. PLoS Pathogens, 9(9), e1003667. (doi: 10.1371/journal.ppat.1003667) (PMID:24086139) (PMCID:PMC3784476)
Rihn, S.J. , Wilson, S.J. , Loman, N.J., Alim, M., Bakker, S.E., Bhella, D. , Gifford, R.J., Rixon, F.J. and Bieniasz, P.D. (2013) Extreme genetic fragility of the HIV-1 capsid. PLoS Pathogens, 9(6), e1003461. (doi: 10.1371/journal.ppat.1003461) (PMID:23818857) (PMCID:PMC3688543)
2012
Wilson, S. J. , Schoggins, J. W., Zang, T., Kutluay, S. B., Jouvenet, N., Alim, M. A., Bitzegeio, J., Rice, C. M. and Bieniasz, P. D. (2012) Inhibition of HIV-1 particle assembly by 2′,3′-cyclic-nucleotide 3′-phosphodiesterase. Cell Host and Microbe, 12(4), pp. 585-597. (doi: 10.1016/j.chom.2012.08.012) (PMID:23084924) (PMCID:PMC3498451)
Yadav, S.S., Wilson, S.J. and Bieniasz, P.D. (2012) A facile quantitative assay for viral particle genesis reveals cooperativity in virion assembly and saturation of an antiviral protein. Virology, 429(2), pp. 155-162. (doi: 10.1016/j.virol.2012.04.008)
2011
Schoggins, J.W., Wilson, S.J. , Panis, M., Murphy, M., Jones, C.T., Bieniasz, P.D. and Rice, C.M. (2011) A diverse range of gene products are effectors of the type I interferon antiviral response. Nature, 472(7344), pp. 481-485. (doi: 10.1038/nature09907) (PMID:21478870) (PMCID:PMC3409588)
Zhang, F., Zang, T., Wilson, S.J. , Johnson, M.C. and Bieniasz, P.D. (2011) Clathrin facilitates the morphogenesis of retrovirus particles. PLoS Pathogens, 7(6), e1002119. (doi: 10.1371/journal.ppat.1002119)
2010
Pardieu, C., Vigan, R., Wilson, S.J. , Calvi, A., Zang, T., Bieniasz, P., Kellam, P., Towers, G.J. and Neil, S.J.D. (2010) The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin. PLoS Pathogens, 6(4), e1000843. (doi: 10.1371/journal.ppat.1000843)
2009
Price, A. J., Marzetta, F., Lammers, M., Ylinen, L.M.J., Schaller, T., Wilson, S.J. , Towers, G.J. and James, L.C. (2009) Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. Nature Structural and Molecular Biology, 16(10), pp. 1036-42. (doi: 10.1038/nsmb.1667)
Dalton-Griffin, L., Wilson, S.J. and Kellam, P. (2009) X-box binding protein 1 contributes to induction of the Kaposi's sarcoma-associated herpesvirus lytic cycle under hypoxic conditions. Journal of Virology, 83(14), pp. 7202-7209. (doi: 10.1128/JVI.00076-09)
Zaitseva, L., Cherepanov, P., Leyens, L., Wilson, S.J. , Rasaiyaah, J. and Fassati, A. (2009) HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome. Retrovirology, 6(11), (doi: 10.1186/1742-4690-6-11)
Zhang, F., Wilson, S.J. , Landford, W.C., Virgen, B., Gregory, D., Johnson, M.C., Munch, J., Kirchoff, F., Bieniasz, P.D. and Hatziioannou, T. (2009) Nef proteins from simian immunodeficiency viruses are tetherin antagonists. Cell Host and Microbe, 6(1), pp. 54-67. (doi: 10.1016/j.chom.2009.05.008)
2008
Wilson, S.J. , Webb, B.L.J., Maplanka, C., Newman, R.M., Verschoor, E.J., Heeney, J.L. and Towers, G.J. (2008) Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities. Journal of Virology, 82(14), pp. 7243-7247. (doi: 10.1128/JVI.00307-08)
Wilson, S.J. , Webb, B.L.J., Ylinen, L.M., Verschoor, E., Heeney, J.L. and Towers, G.J. (2008) Independent evolution of an antiviral TRIMCyp in rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America, 105(9), 3557 -3562. (doi: 10.1073/pnas.0709003105)
2007
Wilson, S.J. , Tsao, E.H., Webb, B.L.J., Ye, H., Dalton-Griffin, L., Tsantoulas, C., Gale, C.V., Du, M.-Q., Whitehouse, A. and Kellam, P. (2007) X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency. Journal of Virology, 81(24), pp. 13578-13586. (doi: 10.1128/JVI.01663-07)
2006
Clements, M.O., Godfrey, A., Crossley, J., Wilson, S.J. , Takeuchi, Y. and Boshoff, C. (2006) Lentiviral manipulation of gene expression in human adult and embryonic stem cells. Tissue Engineering, 12(7), pp. 1741-1751. (doi: 10.1089/ten.2006.12.1741)
2005
Ylinen, L.M.J., Keckesova, Z., Wilson, S.J. , Ranasinghe, S. and Towers, G.J. (2005) Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles. Journal of Virology, 79(18), pp. 11580-11587. (doi: 10.1128/JVI.79.18.11580-11587.2005)
Articles
Lytras, S. et al. (2023) Resurrection of 2′-5′-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication. PLoS Biology, 21(11), e3002398. (doi: 10.1371/journal.pbio.3002398) (PMID:38015855)
Pinto, R. M. et al. (2023) BTN3A3 evasion promotes the zoonotic potential of influenza A viruses. Nature, 619(7969), pp. 338-347. (doi: 10.1038/s41586-023-06261-8) (PMID:37380775)
Hardy, A. et al. (2023) The timing and magnitude of the type I interferon response are correlated with disease tolerance in arbovirus infection. mBio, 14(3), e0010123. (doi: 10.1128/mbio.00101-23) (PMID:37097030) (PMCID:PMC10294695)
Sugrue, E. et al. (2022) The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness. PLoS Pathogens, 18(11), e1010973. (doi: 10.1371/journal.ppat.1010973) (PMID:36399512) (PMCID:PMC9718408)
Crozier, T. W.M. et al. (2022) Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion. Wellcome Open Research, 7, 224. (doi: 10.12688/wellcomeopenres.17946.1) (PMID:36483314) (PMCID:PMC9706147)
Bamford, C. G.C., Aranday-Cortes, E. , Sanchez-Velazquez, R., Mullan, C., Kohl, A. , Patel, A. H. , Wilson, S. J. and McLauchlan, J. (2022) A human and rhesus macaque interferon-stimulated gene screen shows that over-expression of ARHGEF3/XPLN inhibits replication of hepatitis C virus and other flavivirids. Viruses, 14(8), 1655. (doi: 10.3390/v14081655) (PMID:36016278) (PMCID:PMC9414520)
Fielding, C. A. et al. (2022) SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife, 11, e74489. (doi: 10.7554/elife.74489) (PMID:35587364) (PMCID:PMC9239683)
Galão, R. P., Wilson, H., Schierhorn, K. L., Debeljak, F., Bodmer, B. S., Goldhill, D., Hoenen, T., Wilson, S. J. , Swanson, C. M. and Neil, S. J. D. (2022) TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction. PLoS Pathogens, 18(5), e1010530. (doi: 10.1371/journal.ppat.1010530) (PMID:35533151) (PMCID:PMC9119685)
Wickenhagen, A. et al. (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science, 374(6567), eabj3624. (doi: 10.1126/science.abj3624) (PMID:34581622)
Shaw, A. E. et al. (2021) The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. PLoS Biology, 19(9), e3001352. (doi: 10.1371/journal.pbio.3001352) (PMID:34491982) (PMCID:PMC8423302)
Szemiel, A. M. et al. (2021) In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2. PLoS Pathogens, 17(9), e1009929. (doi: 10.1371/journal.ppat.1009929) (PMID:34534263) (PMCID:PMC8496873)
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
Ruddell, S., Sugrue, E. , Memarzadeh, S., Hellam, L. M., Wilson, S. and France, D. (2021) Synthesis, enantiomeric resolution and biological evaluation of HIV capsid inhibition activity for racemic, (S)- and (R)-PF74. Molecules, 26(13), 3919. (doi: 10.3390/molecules26133919) (PMID:34206893) (PMCID:PMC8272108)
Lin, Y.-T., Chiweshe, S., McCormick, D., Raper, A., Wickenhagen, A., DeFillipis, V., Gaunt, E., Simmonds, P., Wilson, S. J. and Grey, F. (2020) Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early 1 gene. PLoS Pathogens, 16(9), e1008844. (doi: 10.1371/journal.ppat.1008844) (PMID:32886716) (PMCID:PMC7498042)
Rihn, S. J. et al. (2019) TRIM69 inhibits vesicular stomatitis Indiana virus (VSIV). Journal of Virology, 93(20), e00951-19. (doi: 10.1128/JVI.00951-19) (PMID:31375575)
Dennis, T. P.W., Souza, W. M. d., Marsile-Medun, S., Singer, J. B., Wilson, S. J. and Gifford, R. J. (2019) The evolution, distribution and diversity of endogenous circoviral elements in vertebrate genomes. Virus Research, 262, pp. 15-23. (doi: 10.1016/j.virusres.2018.03.014) (PMID:29601845) (PMCID:PMC6372831)
Dennis, T. P.W., Flynn, P. J., Souza, W. M. d., Singer, J. B., Moreau, C. S., Wilson, S. J. and Gifford, R. J. (2018) Insights into circovirus host range from the genomic fossil record. Journal of Virology, 92(16), e00145-18. (doi: 10.1128/JVI.00145-18) (PMID:29875243) (PMCID:PMC6069186)
Feng, J. et al. (2018) Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20. Journal of Virology, 92(13), e02140-17. (doi: 10.1128/JVI.02140-17) (PMID:29695422) (PMCID:PMC6002717)
Shaw, A. E. et al. (2017) Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses. PLoS Biology, 15(12), e2004086. (doi: 10.1371/journal.pbio.2004086) (PMID:29253856) (PMCID:PMC574750)
Rihn, S. J. , Foster, T. L., Busnadiego, I., Aziz, M. A. B., Hughes, J. , Neil, S. J.D. and Wilson, S. J. (2017) The envelope gene of transmitted HIV-1 resists a late interferon gamma-induced block. Journal of Virology, 91(7), e02254-16. (doi: 10.1128/JVI.02254-16) (PMID:28100611) (PMCID:PMC5355616)
Terry, A., Kilbey, A., Naseer, A., Levy, L. S., Ahmad, S., Watts, C., Mackay, N., Cameron, E. , Wilson, S. and Neil, J. C. (2017) Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis. Journal of Virology, 91(5), e02119-16. (doi: 10.1128/JVI.02119-16) (PMID:28031367) (PMCID:PMC5309941)
Kane, M., Zang, T. M., Rihn, S. J. , Zhang, F., Kueck, T., Alim, M., Schoggins, J., Rice, C. M., Wilson, S. J. and Bieniasz, P. D. (2016) Identification of interferon-stimulated genes with antiretroviral activity. Cell Host and Microbe, 20(3), pp. 392-405. (doi: 10.1016/j.chom.2016.08.005) (PMID:27631702) (PMCID:PMC5026698)
Dittmann, M. et al. (2015) A Serpin shapes the extracellular environment to prevent influenza A virus maturation. Cell, 160(4), pp. 631-643. (doi: 10.1016/j.cell.2015.01.040) (PMID:25679759) (PMCID:PMC4328142)
Rihn, S. J. , Hughes, J. , Wilson, S. J. and Bieniasz, P. D. (2015) Uneven genetic robustness of HIV-1 integrase. Journal of Virology, 89(1), pp. 552-567. (doi: 10.1128/JVI.02451-14)
Busnadiego, I. et al. (2014) Host and viral determinants of Mx2 antiretroviral activity. Journal of Virology, 88(14), pp. 7738-7752. (doi: 10.1128/JVI.00214-14) (PMID:24760893) (PMCID:PMC4097781)
Kane, M. et al. (2013) MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature, 502(7472), pp. 563-566. (doi: 10.1038/nature12653)
Soll, S. J., Wilson, S. J. , Kutluay, S. B., Hatziioannou, T. and Bieniasz, P. D. (2013) Assisted evolution enables HIV-1 to overcome a high trim5α-imposed genetic barrier to rhesus macaque tropism. PLoS Pathogens, 9(9), e1003667. (doi: 10.1371/journal.ppat.1003667) (PMID:24086139) (PMCID:PMC3784476)
Rihn, S.J. , Wilson, S.J. , Loman, N.J., Alim, M., Bakker, S.E., Bhella, D. , Gifford, R.J., Rixon, F.J. and Bieniasz, P.D. (2013) Extreme genetic fragility of the HIV-1 capsid. PLoS Pathogens, 9(6), e1003461. (doi: 10.1371/journal.ppat.1003461) (PMID:23818857) (PMCID:PMC3688543)
Wilson, S. J. , Schoggins, J. W., Zang, T., Kutluay, S. B., Jouvenet, N., Alim, M. A., Bitzegeio, J., Rice, C. M. and Bieniasz, P. D. (2012) Inhibition of HIV-1 particle assembly by 2′,3′-cyclic-nucleotide 3′-phosphodiesterase. Cell Host and Microbe, 12(4), pp. 585-597. (doi: 10.1016/j.chom.2012.08.012) (PMID:23084924) (PMCID:PMC3498451)
Yadav, S.S., Wilson, S.J. and Bieniasz, P.D. (2012) A facile quantitative assay for viral particle genesis reveals cooperativity in virion assembly and saturation of an antiviral protein. Virology, 429(2), pp. 155-162. (doi: 10.1016/j.virol.2012.04.008)
Schoggins, J.W., Wilson, S.J. , Panis, M., Murphy, M., Jones, C.T., Bieniasz, P.D. and Rice, C.M. (2011) A diverse range of gene products are effectors of the type I interferon antiviral response. Nature, 472(7344), pp. 481-485. (doi: 10.1038/nature09907) (PMID:21478870) (PMCID:PMC3409588)
Zhang, F., Zang, T., Wilson, S.J. , Johnson, M.C. and Bieniasz, P.D. (2011) Clathrin facilitates the morphogenesis of retrovirus particles. PLoS Pathogens, 7(6), e1002119. (doi: 10.1371/journal.ppat.1002119)
Pardieu, C., Vigan, R., Wilson, S.J. , Calvi, A., Zang, T., Bieniasz, P., Kellam, P., Towers, G.J. and Neil, S.J.D. (2010) The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin. PLoS Pathogens, 6(4), e1000843. (doi: 10.1371/journal.ppat.1000843)
Price, A. J., Marzetta, F., Lammers, M., Ylinen, L.M.J., Schaller, T., Wilson, S.J. , Towers, G.J. and James, L.C. (2009) Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. Nature Structural and Molecular Biology, 16(10), pp. 1036-42. (doi: 10.1038/nsmb.1667)
Dalton-Griffin, L., Wilson, S.J. and Kellam, P. (2009) X-box binding protein 1 contributes to induction of the Kaposi's sarcoma-associated herpesvirus lytic cycle under hypoxic conditions. Journal of Virology, 83(14), pp. 7202-7209. (doi: 10.1128/JVI.00076-09)
Zaitseva, L., Cherepanov, P., Leyens, L., Wilson, S.J. , Rasaiyaah, J. and Fassati, A. (2009) HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome. Retrovirology, 6(11), (doi: 10.1186/1742-4690-6-11)
Zhang, F., Wilson, S.J. , Landford, W.C., Virgen, B., Gregory, D., Johnson, M.C., Munch, J., Kirchoff, F., Bieniasz, P.D. and Hatziioannou, T. (2009) Nef proteins from simian immunodeficiency viruses are tetherin antagonists. Cell Host and Microbe, 6(1), pp. 54-67. (doi: 10.1016/j.chom.2009.05.008)
Wilson, S.J. , Webb, B.L.J., Maplanka, C., Newman, R.M., Verschoor, E.J., Heeney, J.L. and Towers, G.J. (2008) Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities. Journal of Virology, 82(14), pp. 7243-7247. (doi: 10.1128/JVI.00307-08)
Wilson, S.J. , Webb, B.L.J., Ylinen, L.M., Verschoor, E., Heeney, J.L. and Towers, G.J. (2008) Independent evolution of an antiviral TRIMCyp in rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America, 105(9), 3557 -3562. (doi: 10.1073/pnas.0709003105)
Wilson, S.J. , Tsao, E.H., Webb, B.L.J., Ye, H., Dalton-Griffin, L., Tsantoulas, C., Gale, C.V., Du, M.-Q., Whitehouse, A. and Kellam, P. (2007) X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency. Journal of Virology, 81(24), pp. 13578-13586. (doi: 10.1128/JVI.01663-07)
Clements, M.O., Godfrey, A., Crossley, J., Wilson, S.J. , Takeuchi, Y. and Boshoff, C. (2006) Lentiviral manipulation of gene expression in human adult and embryonic stem cells. Tissue Engineering, 12(7), pp. 1741-1751. (doi: 10.1089/ten.2006.12.1741)
Ylinen, L.M.J., Keckesova, Z., Wilson, S.J. , Ranasinghe, S. and Towers, G.J. (2005) Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles. Journal of Virology, 79(18), pp. 11580-11587. (doi: 10.1128/JVI.79.18.11580-11587.2005)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Protein Degradation as an Anti-viral Strategy
Engineering and Physical Sciences Research Council
2021 - 2024
- Identifying the Host and Viral Determinants of Coronavirus Emergence and Adaptation in Human Populations
Medical Research Council
2020 - 2023
- Swingler Daphne Jackson Fellowship
Daphne Jackson Trust
2020 - 2023
- COVID-19: Screening of ReFRAME collection
Bill and Melinda Gates Foundation
2020 - 2020
- Identification of interferon stimulated genes that restrict cross-species transmission of influenza A virus
Biotechnology and Biological Sciences Research Council
2019 - 2022
- Host and Viral Determinants of Interferon Resistance During HIV-1 Transmission
Medical Research Council
2018 - 2020
- The role of ISGs in HIV-1 transmision
Medical Research Council
2018 - 2020
- Quinquennial Core Funds
Medical Research Council
2016 - 2021
- Comparing the fitness and patient landscapes of HIV-1 (ISSF Catalyst)
Wellcome Trust
2014 - 2015
- Identifying and characterising antiretroviral interferon stimulated genes (ISGs)
Medical Research Council
2013 - 2018
Research datasets
2022
Sugrue, E. , Wickenhagen, A., Mollentze, N. , Aziz, M. A., Sreenu, V. B., Truxa, S., Tong, L., Da Silva Filipe, A. , Robertson, D. , Hughes, J. , Rihn, S. and Wilson, S. (2022) The Interferon Resistance of Transmitted HIV-1 is Possibly a Consequence of Enhanced Replicative Fitness. [Data Collection]
2021
Wickenhagen, A., Sugrue, E. , Lytras, S., Kuchi, S., Noerenberg, M. , Turnbull, M. , Loney, C. , Herder, V., Allan, J., Jarmson, I., Cameron Ruiz, N., Varjak, M. , Pinto, R. , Lee, J. Y., Iselin, L., Palmalux, N., Stewart, D., Swingler, S., Greenwood, E. J. D., Crozier, T. W. M., Gu, Q. , Davies, E., Clohisey, S., Wang, B., Trindade Maranhã Costa, F., Santana, M. F., Carlos de Lima Ferreira, L., Murphy, L., Fawkes, A., Meynert, A., Grimes, G., ISARICC investigators, , Da Silva Filho, J. , Marti, M. , Hughes, J. , Stanton, R. J., Wang, E. C. Y., Ho, A. , Davis, I., Jarrett, R. , Castello, A. , Robertson, D. , Semple, M. G., Openshaw, P. J. M., Palmarini, M. , Lehner, P. J., Baillie, K., Rihn, S. and Wilson, S. (2021) A Prenylated dsRNA Sensor Protects Against Severe COVID-19. [Data Collection]
Shaw, A., Rihn, S. , Mollentze, N. , Wickenhagen, A., Stewart, D., Orton, R. , Kuchi, S., Bakshi, S., Collados Rodriguez, M. , Turnbull, M. , Busby, J., Gu, Q. , Smollett, K., Bamford, C., Sugrue, E. , Johnson, P. , Da Silva Filipe, A. , Castello, A. , Streicker, D. , Robertson, D. , Palmarini, M. and Wilson, S. (2021) The 'antiviral state' has shaped the CpG composition of the vertebrate interferome to avoid self-targeting. [Data Collection] (Unpublished)
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