Prof Michael Stear

Prof Michael J Stear
  • Professor of Immunogenetics (Infection Immunity and Inflammation Life Sciences)
  • Associate Academic (School of Veterinary Medicine)

telephone: 01413305762
email: Michael.Stear@glasgow.ac.uk


My major interest is in understanding and controlling nematode infections. Most of my research is on Teladorsagia circumcincta infections of sheep. This host-parasite association was chosen deliberately because it is an economically-important infection of sheep. Most advances in our understanding of host-parasite relationships have come from a detailed analysis of deliberate infections or mathematical modelling of natural infections. Both strategies can be used to study parasites of sheep. The plan is to develop a coherent explanation that covers all levels from populations to molecules. Among the achievements are the use of variance analysis to identify and quantify the major components of resistance, the demonstration that many components including the heritability and sex differences vary with age, the finding that a major mechanism of resistance in growing lambs is the mucosal IgA response against fourth-stage larvae which is associated with reduced worm growth and fecundity and the identification of two quantitative trait loci (QTL) for parasite resistance; one in the mhc class II region and one in or around the interferon gamma gene. Our current research aims to identify the parasite molecules recognised by resistant but not susceptible hosts.

Jump to: 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 1997
Number of items: 42.

2012

Codner, G.F., Stear, M.J. , Reeve, R. , Matthews, L. , and Ellis, S.A. (2012) Selective forces shaping diversity in the class I region of the major histocompatibility complex in dairy cattle. Animal Genetics, 43 (3). pp. 239-249. ISSN 0268-9146 (doi:10.1111/j.1365-2052.2011.02239.x)

Jonsson, N.N., Bock, R.E., Jorgensen, W.K., Morton, J.M., and Stear, M.J. (2012) Is endemic stability of tick-borne disease in cattle a useful concept? Trends in Parasitology, 28 (3). pp. 85-89. ISSN 1471-4922 (doi:10.1016/j.pt.2011.12.002)

2011

Singleton, D.R., Stear, M.J. , and Matthews, L. (2011) A mechanistic model of developing immunity to Teladorsagia circumcincta infection in lambs. Parasitology, 138 (3). pp. 322-332. ISSN 0031-1820 (doi:10.1017/S0031182010001289)

Ballingall, K.T., Herrmann-Hoesing, L., Robinson, J., Marsh, S. G. E., and Stear, M.J. (2011) A single nomenclature and associated database for alleles at the major histocompatibility complex class II DRB1 locus of sheep. Tissue Antigens, 77 (6). pp. 546-553. ISSN 0001-2815 (doi:10.1111/j.1399-0039.2011.01637.x)

Diack, A.B., Gladney, C.D., Mellencamp, M.A., Stear, M.J. , and Eckersall, P.D. (2011) Characterisation of plasma acute phase protein concentrations in a high health boar herd. Veterinary Immunology and Immunopathology, 139 (2-4). pp. 107-112. ISSN 0165-2427 (doi:10.1016/j.vetimm.2010.09.003)

Singleton, D.R., Stear, M.J. , and Matthews, L. (2011) A mechanistic model of developing immunity to Teladorsagia circumcincta infection in lambs. Parasitology, 138 (03). pp. 322-332. ISSN 0031-1820 (doi:10.1017/S0031182010001289)

Stear, M.J., Singleton, D. , and Matthews, L. (2011) An evolutionary perspective on gastrointestinal nematodes of sheep. Journal of Helminthology, 85 (02). pp. 113-120. ISSN 0022-149X (doi:10.1017/S0022149X11000058)

2010

Murphy, L., Eckersall, P.D. , Bishop, S.C., Pettit, J.J., Huntley, J.F., Burchmore, R.J.S. , and Stear, M.J. (2010) Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta. Parasitology, 137 (8). pp. 1249-1260. ISSN 0031-1820 (doi:10.1017/S0031182010000028)

Stirling, D., and Stear, M.J. (2010) g you The direct determination of haplotypes from extended regions of genomic DNA. BMC Genomics, 11 (223). p. 1. ISSN 1471-2164 (doi:10.1186/1471-2164-11-223)

2009

Chessa, B. et al. (2009) Revealing the history of sheep domestication using retrovirus integrations. Science, 324 (5926). pp. 532-536. ISSN 0036-8075 (doi:10.1126/science.1170587)

Chylinski, C., Boag, B. , Stear, M.J. , and Cattadori, I.M. (2009) Effects of host characteristics and parasite intensity on growth and fecundity of Trichostrongylus retortaeformis infections in rabbits. Parasitology, 136 (1). pp. 117-123. ISSN 0031-1820 (doi:10.1017/S0031182008005143)

Gharbi, K., Glover, K.A., Stone, L.C., MacDonald, E.S., Matthews, L. , Grimholt, U., and Stear, M.J. (2009) Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon. BMC Genetics, 10 . p. 20. ISSN 1471-2156 (doi:10.1186/1471-2156-10-20)

Stear, M. J., Boag, B., Cattadori, I. , and Murphy, L. (2009) Genetic variation in resistance to mixed, predominantly Teladorsagia circumcincta nematode infections of sheep: from heritabilities to gene identification. Parasite Immunology, 31 (5). pp. 274-282. ISSN 0141-9838 (doi:10.1111/j.1365-3024.2009.01105.x)

2008

Denwood, M. J., Stear, M. J. , Matthews, L. , Reid, S. W. J. , Toft, N., and Innocent, G. T. (2008) The distribution of the pathogenic nematode Nematodirus battus in lambs is zero-inflated. Parasitology, 135 (10). pp. 1225-1235. ISSN 0031-1820 (doi:10.1017/S0031182008004708)

Eckersall, P.D., Lawson, F.P., Kyle, C.E., Waterston, M., Bence, L. , Stear, M.J. , and Rhind, S.M. (2008) Maternal undernutrition and the ovine acute phase response to vaccination. Bmc Veterinary Research, 4 (1). ISSN 1746-6148 (doi:10.1186/1746-6148-4-1)

2007

Amory, J.R., Mackenzie, A.M., Eckersall, P.D. , Stear, M.J. , and Pearce, G.P. (2007) Influence of rearing conditions and respiratory disease on haptoglobin levels in the pig at slaughter. Research in Veterinary Science, 83 (3). pp. 428-435. ISSN 0034-5288 (doi:10.1016/j.rvsc.2007.01.012)

Stear, MJ et al. (2007) Detection of genes with moderate effects on disease resistance using ovine mhc and resistance to nematodes as an example. Veterinary Immunology and Immunopathology, 120 . pp. 3-9. (doi:10.1016/j.vetimm.2007.07.012)

Stear, MJ, Doligalska, M, and Donskow-Schmelter, K (2007) Alternatives to anthelmintics for the control of nematodes in livestock. Parasitology, 134 . pp. 139-151. (doi:10.1017/S0031182006001557)

Stear, MJ, Fitton, L, Innocent, GT , Murphy, L, Rennie, K, and Matthews, L (2007) The dynamic influence of genetic variation on the susceptibility of sheep to gastrointestinal nematode infection. Journal of the Royal Society: Interface, 4 (16). pp. 767-776. (doi:10.1098/rsif.2007.1104)

Vagenas, D, White, IMS, Stear, MJ , and Bishop, SC (2007) Estimation of heritabilities and correlations between repeated faecal egg count measurements in lambs facing natural nematode parasite challenge, using a random regression model. Journal of Agricultural Science, 145 . pp. 501-508. (doi:10.1017/S0021859607007137)

2006

Davies, G, Stear, MJ , Benothman, M, Abuagob, O, Kerr, A, Mitchell, S, and Bishop, SC (2006) Quantitative trait loci associated with parasitic infection in Scottish blackface sheep. Heredity, 96 . pp. 252-258. (doi:10.1038/sj.hdy.6800788)

Ellis, S.A. et al. (2006) ISAG/IUIS-VIC Comparative MHC Nomenclature Committee report, 2005. Immunogenetics, 57 (12). pp. 953-958. ISSN 0093-7711 (doi:10.1007/s00251-005-0071-4)

Henderson, NG, and Stear, MJ (2006) Eosinophil and IgA responses in sheep infected with Teladorsagia circumcincta. Veterinary Immunology and Immunopathology, 112 . pp. 62-66. (doi:10.1016/j.vetimm.2006.03.012)

Love, S, Wyse, CA, Stirk, AJ, Stear, MJ , Calver, R, Voute, LC , and Mellor, DJ (2006) Prevalence, heritability and significance of musculoskeletal conformational traits in Thoroughbred yearlings. Equine Veterinary Journal, 38 . pp. 597-603. (doi:10.2746/042516406X159016)

2005

Davies, G, Stear, MJ , and Bishop, SC (2005) Genetic relationships between indicator traits and nematode parasite infection levels in 6-month-old lambs. Animal Science, 80 . pp. 143-150.

Ellis, SA, Morrison, WI, MacHugh, ND, Birch, J, Burrells, A, and Stear, MJ (2005) Serological and molecular diversity in the cattle MHC class I region. Immunogenetics, 57 . pp. 601-606. (doi:10.1007/s00251-005-0027-8)

Stear, MJ, Innocent, GT , and Buitkamp, J (2005) The evolution and maintenance of polymorphism in the major histocompatibility complex. Veterinary Immunology and Immunopathology, 108 . pp. 53-57. (doi:10.1016/j.vetimm.2005.07.005)

2004

Bishop, SC, Jackson, F, Coop, RL, and Stear, MJ (2004) Genetic parameters for resistance to nematode infections in Texel lambs and their utility in breeding programmes. Animal Science, 78 . pp. 185-194.

Sayers, G, Mitchel, S, Ryan, M, Stear, MJ , Hanrahan, JP, and Sweeney, T (2004) Analysis of DRB1 exon 2 genotyping by STR size analysis in Suffolk and Texel sheep breeds. Irish Journal of Agricultural and Food Research, 43 . pp. 177-183.

Stear, MJ, Bairden, K, Innocent, GT , Mitchell, S, Strain, S, and Bishop, SC (2004) The relationship between IgA activity against 4th-stage larvae and density-dependent effects on the number of 4th-stage larvae of Teladorsagia circumcincta in naturally infected sheep. Parasitology, 129 . pp. 363-369. (doi:10.1017/S0031182004005736)

2003

Bai, QF, McGillivray, C, da Costa, N, Dornan, S, Evans, G, Stear, MJ , and Chang, KC (2003) Development of a porcine skeletal muscle cDNA microarray: analysis of differential transcript expression in phenotypically distinct muscles. Bmc Genomics, 4 .

Bishop, SC, and Stear, MJ (2003) Modeling of host genetics and resistance to infectious diseases: understanding and controlling nematode infections. Veterinary Parasitology, 115 . pp. 147-166. (doi:10.1016/S0304-4017(03)00204-8)

Stear, M.J., Bishop, S.C., Henderson, N.G., and Scott, I. (2003) A key mechanism of pathogenesis in sheep infected with the nematode Teladorsagia circumcincta. Animal Health Research Reviews, 4 (1). pp. 45-52. ISSN 1466-2523 (doi:10.1079/AHRR200351)

2002

Stear, MJ, Henderson, NG, Kerr, A, McKellar, QA, Mitchell, S, Seeley, C, and Bishop, SC (2002) Eosinophilia as a marker of resistance to Teladorsagia circumcincta in Scottish Blackface lambs. Parasitology, 124 . pp. 553-560. (doi:10.1017/S0031182002001580)

Strain, SAJ, Bishop, SC, Henderson, NG, Kerr, A, McKellar, QA, Mitchell, S, and Stear, MJ (2002) The genetic control of IgA activity against Teladorsagia circumcincta and its association with parasite resistance in naturally infected sheep. Parasitology, 124 . pp. 545-552. (doi:10.1017/S0031182002001531)

2001

Bishop, SC, and Stear, MJ (2001) Inheritance of faecal egg counts during early lactation in Scottish Blackface ewes facing mixed, natural nematode infections. Animal Science, 73 . pp. 389-395.

Coltman, DW, Wilson, K, Pilkington, JG, Stear, MJ , and Pemberton, JM (2001) A microsatellite polymorphism in the gamma interferon gene is associated with resistance to gastrointestinal nematodes in a naturally-parasitized population of Soay sheep. Parasitology, 122 . pp. 571-582.

Nginyi, JM, Duncan, JL, Mellor, DJ , Stear, MJ , Wanyangu, SW, Bain, RK, and Gatongi, PM (2001) Epidemiology of parasitic gastrointestinal nematode infections of ruminants on smallholder farms in central Kenya. Research in Veterinary Science, 70 . pp. 33-39.

Stear, MJ, Bishop, SC, Mallard, BA, and Raadsma, H (2001) The sustainability, feasibility and desirability of breeding livestock for disease resistance. Research in Veterinary Science, 71 . pp. 1-7. (doi:10.1053/rvsc.2001.0496)

Stear, MJ, Eckersall, PD , Graham, PA, McKellar, QA, Mitchell, S, and Bishop, SC (2001) Fructosamine concentration and resistance to natural, predominantly Teladorsagia circumcincta infection. Parasitology, 123 . pp. 211-218.

Strain, SAJ, and Stear, MJ (2001) The influence of protein supplementation on the immune response to Haemonchus contortus. Parasite Immunology, 23 . pp. 527-531. ISSN 0141-9838

1997

Stear, M.J., Bairden, K., Duncan, J.L., Holmes, P.H. , McKellar, Q.A., Park, M., Strain, S., Murray, M., Bishop, S.C., and Gettinby, G. (1997) How hosts control worms. Nature, 389 (6646). p. 27. ISSN 0028-0836 (doi:10.1038/37895)

This list was generated on Thu May 24 16:34:21 2012 BST.
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    Technology Strategy Board (TSB)
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  • Why some hosts have high parasite burdens and the implications for the design of sustainable control strategies
    Wellcome Trust
    2011 - 2014
     
  • A Systems Biology Approach to controlling Nematode Infections of Livestock
    European Commission
    2011 - 2014
     
  • The Feasibility of Breeding Atlantic Salmon for Resistance to Sea Lice.
    DEFRA
    2009 - 2010
     
  • The Feasibility of Breeding Atlantic Salmon for Resistance to Sea Lice.
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  • The effect of selection for nematode resistance on mhc class II diversiity
    BBSRC
    2009 - 2011
     
  • The potential role of phagocytic cells in resistance to scrapie in sheep
    Royal Society
    2007 - 2009
     
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    Quality Meat Scotland
    2006 - 2007
     
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    Royal Society
    2006 - 2009
     
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    Department of Trade & Industry
    2005 - 2006
     
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    British Council - Poland
    2005 - 2007
     
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    2005 - 2005
     
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    Commonwealth Scholarship Commission in the UK
    2004 - 2005
     
  • Integration of functional genomics and immunology and their application to infectious disease in ruminants
    DEFRA
    2004 - 2009