2012

Paunovic, V., Carter, N.A., Thalhamer, T., Blair, D., Gordon, B., Lacey, E., Michie, A.M. , and Harnett, M.M. (2012) Immune complex-mediated co-ligation of the BCR with FcgammaRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of Systemic Lupus Erythematosus. Journal of Autoimmunity . ISSN 0896-8411 (In Press)

Pineda, M.A., McGrath, M.A. , Smith, P.C., Al-Riyami, L. , Rzepecka, J. , Gracie, J.A. , Harnett, W., and Harnett, M.M. (2012) The parasitic helminth product ES-62 suppresses pathogenesis in CIA by targeting of the IL-17-producing cellular network at multiple sites. Arthritis and Rheumatism . ISSN 0004-3591 (In Press)

2011

Norman, J.E., Yuan, M. , Anderson, L. , Howie, F., Harold, G., Young, A., Jordan, F., McInnes, I. , and Harnett, M.M. (2011) Effect of prolonged in vivo administration of progesterone in pregnancy on myometrial gene expression, peripheral blood leukocyte activation, and circulating steroid hormone levels. Reproductive Sciences, 18 (5). pp. 435-446. ISSN 1933-7191 (doi:10.1177/1933719110395404)

2010

Harnett, M. M., Melendez Romero, A. J. , and Harnett, W. (2010) The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease. Clinical and Experimental Immunology, 159 (3). pp. 256-267. ISSN 0009-9104 (doi:10.1111/j.1365-2249.2009.04064.x)

Harnett, W., and Harnett, M. M. (2010) Helminth-derived immunomodulators: can understanding the worm produce the pill? Nature Reviews Immunology, 10 (4). pp. 278-284. ISSN 1474-1733 (doi:10.1038/nri2730)

2009

Harnett, W, and Harnett, M (2009) Immunomodulatory Activity and Therapeutic Potential of the Filarial Nematode Secreted Product, ES-62. Pathogen-Derived Immunomodulatory Molecules, 666 . pp. 88-94.

Leonardo, SM, Harnett, M , Lerch-Gaggl, AF, and Gauld, SB (2009) Fluorescence-based assays as tools for understanding immunologic processes. Annals of Allergy Asthma and Immunology, 102 (1). pp. 84-90.

Yuan, M, Jordan, F , McInnes, I , Harnett, M , and Norman, JE (2009) Leukocytes are primed in peripheral blood for activation during term and preterm labour. Molecular Human Reproduction, 15 (11). pp. 713-724. ISSN 1360-9947 (doi:10.1093/molehr/gap054)

2008

Harnett, M et al. (2008) The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis. Annals of the Rheumatic Diseases, 67 (4). pp. 518-523. ISSN 0003-4967 (doi:10.1136/ard.2007.073502)

Harnett, W, and Harnett, M (2008) Lymphocyte hyporesponsiveness during filarial nematode infection. Parasite Immunology, 30 (9). pp. 447-453. ISSN 0141-9838

Marshall, F.A., Watson, K.A., Garside, P. , Harnett, M. , and Harnett, W. (2008) Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo. Immunology, 123 (3). pp. 411-425. ISSN 0019-2805 (doi:10.1111/j.1365-2567.2007.02706.x)

Thalhamer, T, McGrath, MA, and Harnett, M (2008) MAPKs and their relevance to arthritis and inflammation. Rheumatology, 47 (4). pp. 409-414. ISSN 1462-0324

2007

Goodridge, HS, McGuiness, S, Houston, KM, Egan, CA, Al-Riyami, L, Alcocer, MJC, Harnett, MM , and Harnett, W (2007) Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells. Parasite Immunology, 29 . pp. 127-137. ISSN 0141-9838 (doi:10.1111/j.1365-3024.2006.00926.x)

Harnett, MM (2007) Laser scanning cytometry: understanding the immune system in situ. Nature Reviews Immunology, 7 . pp. 897-904. ISSN 1474-1733

Harnett, MM, Harnett, W, McSharry, CP, Melendez, AJ, Pushparaj, PN, Tay, HK, and Wong, WF (2007) Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes. Nature Medicine, 13 . pp. 1375-1381. (doi:10.1038/nm1654)

Morton, AM, McManus, B, Garside, P, Mowat, AM , and Harnett, M (2007) Inverse Rap1 and phospho-ERK expression discriminate the maintenance phase of tolerance and priming of antigen-specific CD4(+) T cells in vitro and in vivo. Journal of Immunology, 179 (12). pp. 8026-8034.

2006

Harnett, W, and Harnett, MM (2006) Filarial nematode secreted product ES-62 is an anti-inflammatory agent: Therapeutic potential of small molecule derivatives and ES-62 peptide mimetics. Clinical and Experimental Pharmacology and Physiology, 33 . pp. 511-518.

Harnett, W, and Harnett, MM (2006) Molecular basis of worm-induced immunomodulation. Parasite Immunology, 28 . pp. 535-543. ISSN 0141-9838 (doi:10.1111/j.1365-3024.2006.00893.x)

Harnett, W, and Harnett, MM (2006) What causes lymphocyte hyporesponsiveness during filarial nematode infection? Trends in Parasitology, 22 . pp. 105-110. (doi:10.1016/j.pt.2006.01.010)

Kean, DE, Goodridge, HS, McGuinness, S, Harnett, MM , Alcocer, MJC, and Harnett, W (2006) Differential polarization of immune responses by plant 2S seed albumins, ber e 1, and SFA8. Journal of Immunology, 177 . pp. 1561-1566.

Kean, DE, Ohtsuka, I, Sato, K, Hada, N, Takeda, T, Lochnit, G, Geyer, R, Harnett, MM , and Harnett, W (2006) Dissecting Ascaris glycosphingolipids for immunomodulatory moieties - the use of synthetic structural glycosphingolipid analogues. Parasite Immunology, 28 . pp. 69-76. ISSN 0141-9838 (doi:10.1111/j.1365-3024.2005.00801.x)

2005

Al, RL, Egan, C, Else, KJ, Goodridge, HS, Harnett, MM , Harnett, W, Houston, KM, Liew, FY , and Marshall, FA (2005) Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. Journal of Immunology, 174 . pp. 284-293.

Goodridge, HS, and Harnett, MM (2005) Introduction to immune cell signalling. Parasitology, 130 . S3-S9. (doi:10.1017/S0031182005008115)

Goodridge, HS, Stepek, G, Harnett, W, and Harnett, MM (2005) Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62. Immunology, 115 . pp. 296-304. (doi:10.1111/j.1365-2567.2005.02167.x)

Goodrigde, HS, Deehan, MR, Harnett, W, and Harnett, MM (2005) Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product. Cellular Signalling, 17 . pp. 11-16. (doi:10.1016/j.cellsig.2004.05.014)

Grierson, AM, Mitchell, P, Adams, CL, Mowat, AM , Brewer, JM , Harnett, MM , and Garside, P (2005) Direct quantitation of T cell signaling by laser scanning cytometry. Journal of Immunological Methods, 301 . pp. 140-153. (doi:10.1016/j.jim.2005.04.011)

Harnett, MA, Katz, E, and Ford, CA (2005) Differential signalling during B-cell maturation. Immunology Letters, 98 . pp. 33-44.

Harnett, W, Goodridge, HS, and Harnett, MM (2005) Subversion of immune cell signal transduction pathways by the secreted filarial nematode product, ES-62. Parasitology, 130 . S63-S68. (doi:10.1017/S0031182005008164)

Marshall, FA, Grierson, AM, Garside, P , Harnett, W, and Harnett, MM (2005) ES-62, an immunomodulator secreted by filarial nematodes, suppresses clonal expansion and modifies effector function of heterologous antigen-specific T cells in vivo. Journal of Immunology, 175 . pp. 5817-5826.

2004

Adams, CL, Grierson, AM, Mowat, AM , Harnett, MM , and Garside, P (2004) Differences in the kinetics, amplitude, and localization of ERK activation in anergy and priming revealed at the level of individual primary T cells by laser scanning cytometry. Journal of Immunology, 173 . pp. 1579-1586.

Brown, KS, Blair, D, Reid, SD, Nicholson, EK, and Harnett, MM (2004) Fc gamma RIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3 '-inositol phosphatase, PTEN. Cellular Signalling, 16 . pp. 71-80. (doi:10.1016/S0898-6568(03)00113-X)

Carter, NA, and Harnett, MM (2004) Dissection of the signalling mechanisms underlying Fc gamma RIIB-mediated apoptosis of mature B-cells. Biochemical Society Transactions, 32 . pp. 973-975.

Goodridge, HS, Harnett, MM , Harnett, W, Houston, KM, Liew, FY , Marshall, FA, and Wilson, EH (2004) In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype. Immunology, 113 . pp. 491-498. (doi:10.1111/j.1365-2567.2004.01993.x)

Katz, E, Lord, C, Ford, CA, Gauld, SB, Carter, NA, and Harnett, MM (2004) Bcl-x(L) antagonism of BCR-coupled mitochondrial phospholipase A(2) signaling correlates with protection from apoptosis in WEHI-231 B cells. Blood, 103 . pp. 168-176. (doi:10.1182/blood-2003-07-2473)

Welsh, DJ, Harnett, M , Maclean, M, and Peacock, AJ (2004) Proliferation and signaling in fibroblasts - Role of 5-hydroxytryptamine(2A) receptor and transporter. American Journal of Respiratory and Critical Care Medicine, 170 . pp. 252-259. ISSN 1073-449X (doi:10.1164/rccm.200302-264OC)

2003

McInnes, I.B., Gracie, J.A., Harnett, M. , Harnett, W., and Liew, F.Y. (2003) New strategies to control inflammatory synovitis: interleukin 15 and beyond. Annals of the Rheumatic Diseases, 62 (2). pp. 51-54. ISSN 0003-4967 (doi:10.1136/ard.62.suppl_2.ii51)

Goodridge, HS, Harnett, MM , Harnett, W, and Liew, FY (2003) Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses. Immunology, 109 . pp. 415-425.

Smith, RE et al. (2003) A novel MyD-1 (SIRP-1 alpha) signaling pathway that inhibits LPS-induced TNF alpha production by monocytes. Blood, 102 . pp. 2532-2540. (doi:10.1182/blood-2002-11-3596)

Wilson, EH, Deehan, MR, Katz, E, Brown, KS, Houston, KM, OGrady, J, Harnett, MM , and Harnett, W (2003) Hyporesponsiveness of murine B lymphocytes exposed to the filarial nematode secreted product ES-62 in vivo. Immunology, 109 . pp. 238-245.

2002

Cameron, AJM, McDonald, KJ , Harnett, MM , and Allen, JM (2002) Differentiation of the human monocyte cell line, U937, with dibutyryl cyclicAMP induces the expression of the inhibitory Fc receptor, Fc gamma RIIb. Immunology Letters, 83 . pp. 171-179.

Deehan, MR, Goodridge, HS, Blair, D, Lochnit, G, Dennis, RD, Geyer, R, Harnett, MM , and Harnett, W (2002) Immunomodulatory properties of Ascaris suum glycosphingolipids - phosphorylcholine and non-phosphorylcholine-dependent effects. Parasite Immunology, 24 . pp. 463-469. ISSN 0141-9838

Gauld, SB, Blair, D, Moss, CA, Reid, SD, and Harnett, MM (2002) Differential roles for extracellularly regulated kinase-mitogen-activated protein kinase in B cell antigen receptor-induced apoptosis and CD40-mediated rescue of WEHI-231 immature B cells. Journal of Immunology, 168 . pp. 3855-3864.

2001

Cameron, AJM, Harnett, MM , and Allen, JM (2001) Differential recruitment of accessory molecules by Fc gamma RI during monocyte differentiation. European Journal of Immunology, 31 . pp. 2718-2725.

Campbell, CC, Goodridge, HS, Harnett, MM , Harnett, W, Liew, FY , and Wilson, EH (2001) Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae. Journal of Immunology, 167 . pp. 940-945.

Deehan, MR, Harnett, MM , Katz, E, Lord, C, Seatter, S, and Sturrock, RD (2001) B cell receptor-stimulated mitochondrial phospholipase A(2) activation and resultant disruption of mitochondrial membrane potential correlate with the induction of apoptosis in WEHI-231 B cells. Journal of Immunology, 166 . pp. 137-147.

Deehan, MR, Harnett, W, and Harnett, MM (2001) A filarial nematode-secreted phosphorylcholine-containing glycoprotein uncouples the B cell antigen receptor from extracellular signal-regulated kinase-mitogen-activated protein kinase by promoting the surface Ig-mediated recruitment of Src homology 2 dom. Journal of Immunology, 166 . pp. 7462-7468.

Harnett, MM, and Harnett, W (2001) Antigen receptor signaling is subverted by an immunomodulatory product secreted by a filarial nematode. Archivum Immunologiae et Therapiae Experimentalis, 49 . pp. 263-269.

Harnett, W, and Harnett, MM (2001) Modulation of the host immune system by phosphorylcholine-containing glycoproteins secreted by parasitic filarial nematodes. Biochimica et Biophysica Acta-molecular Cell Research, 1539 . pp. 7-15.

Melendez, AJ, Bruetschy, L, Floto, RA, Harnett, MM , and Allen, JM (2001) Functional coupling of Fc gamma RI to nicotinamide adenine dinucleotide phosphate (reduced form) oxidative burst and immune complex trafficking requires the activation of phospholipase D1. Blood, 98 . pp. 3421-3428.

Siepmann, K, Skok, J, Van Essen, D, Harnett, M , and Gray, D (2001) Rewiring of CD40 is necessary for delivery of rescue signals to B cells in germinal centres and subsequent entry into the memory pool. Immunology, 102 . pp. 263-272.

Welsh, DJ, Peacock, AJ, MacLean, M , and Harnett, M (2001) Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmonary but not systemic arteries. American Journal of Respiratory and Critical Care Medicine, 164 . pp. 282-289. ISSN 1073-449X