Prof James Neil

  • Professor of Virology and Molecular Oncology (Centre for Virus Research)
  • Associate Academic (School of Veterinary Medicine)
  • Associate Academic (Institute of Cancer Sciences)

telephone: 01413302365
email: James.Neil@glasgow.ac.uk


My research group's work stems from a long-standing interest in retroviruses, particularly as agents of cancer (Cancer Cell 2002, 2: 253-5). This work has led to the identification of cellular oncogenes and tumour suppressor genes that are also important in cancers of non-viral etiology. A major focus of our CR-UK/LLR funded programme is the Runx genes, a three-membered family of transcription factors that can be activated by retroviruses in mouse lymphomas but play wider roles as targets for chromosomal translocations in human leukaemia. Paradoxically, the Runx family is also implicated in tumour suppression as shown by loss of function mutations in some human leukaemias (Nature Reviews on Cancer 2005, 5: 376-87). The Runx genes play multiple roles in cell fate determination in normal development and our findings show that they influence key events relevant to cancer including the regulation of apoptosis and senescence (Cancer Research 2006, 66: 2195-201; 2007 11263-71, Oncogene 2009, 28:2502-12). Moreover, we have recently discovered a novel link between the Runx genes and sphingolipid metabolism that appears to be important for their oncogenic effects (Cancer Res 2010, 70, 5860-9) and we are currently exploring these aspects of Runx function in cancer cell survival and maintenance. In parallel, we are continuing to develop insertional mutagenesis as a cancer gene discovery tool (Cancer Res 2007, 67:5126-33) and we are using the power of next generation sequencing to adapt this approach to retroviral mutagenesis of the human genome. This work has also highlighted the intrinsic resistance mechanisms that limit cross-species transfer of retroviruses.


 

Jump to: 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 1996 | 1995 | 1994 | 1988
Number of items: 36.

2011

Emons, J. et al. (2011) Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation. Journal of Endocrinology, 209 (2). pp. 245-254. ISSN 0022-0795 (doi:10.1530/JOE-10-0219)

2010

Blyth, K., Vaillant, F., Jenkins, A., McDonald, L., Pringle, M.A., Huser, C., Stein, T., Neil, J., and Cameron, E.R. (2010) Runx2 in normal tissues and cancer cells: A developing story. Blood, Cells, Molecules and Diseases, 45 (2). pp. 117-123. ISSN 1079-9796 (doi:10.1016/j.bcmd.2010.05.007)

Kilbey, A., Terry, A., Jenkins, A., Borland, G., Zhang, Q.F., Wakelam, M.J.O., Cameron, E.R., and Neil, J.C. (2010) Runx Regulation of Sphingolipid Metabolism and Survival Signaling. Cancer Research, 70 (14). pp. 5860-5869. ISSN 0008-5472 (doi:10.1158/0008-5472.CAN-10-0726)

Krapf, G., Kaindl, U., Kilbey, A., Fuka, G., Inthal, A., Joas, R., Mann, G., Neil, J.C., Haas, O.A., and Panzer-Grümayer, E.R. (2010) ETV6/RUNX1 abrogates mitotic checkpoint function and targets its key player MAD2L1. Oncogene, 29 (22). pp. 3307-3312. ISSN 0950-9232 (doi:10.1038/onc.2010.53)

2009

Blyth, K., Slater, N., Hanlon, L., Bell, M., Mackay, N., Stewart, M., Neil, J.C., and Cameron, E.R. (2009) Runx1 promotes B-cell survival and lymphoma development. Blood, Cells, Molecules and Diseases, 43 (1). pp. 12-19. ISSN 1079-9796 (doi:10.1016/j.bcmd.2009.01.013)

Scobie, L. et al. (2009) A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity. Molecular Therapy, 17 (6). pp. 1031-1038. ISSN 1525-0016 (doi:10.1038/mt.2009.59 )

Scobie, L. et al. (2009) A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of γC gene oncogenici. Molecular Therapy, 17 (6). pp. 1031-1038. ISSN 1525-0016 (doi:10.1038/mt.2009.59)

Wolyniec, K., Wotton, S., Kilbey, A., Jenkins, A., Terry, A., Peters, G., Stocking, C., Cameron, E.R., and Neil, J.C. (2009) RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress. Oncogene, 28 (27). pp. 2502-2512. ISSN 0950-9232 (doi:10.1038/onc.2009.101)

2008

Kilbey, A., Terry, A., Cameron, E.R., and Neil, J.C. (2008) Oncogene-induced senescence: an essential role for Runx. Cell Cycle, 7 (15). pp. 2333-2340. ISSN 1538-4101

Wotton, S., Terry, A., Kilbey, A., Jenkins, A., Herzyk, P., Cameron, E., and Neil, J.C. (2008) Gene array analysis reveals a common Runx transcriptional programme controlling cell adhesion and survival. Oncogene, 27 (44). pp. 5856-5866. ISSN 0950-9232 (doi:10.1038/onc.2008.195)

2007

Stewart, M, Mackay, N, Hanlon, L, Blyth, K, Scobie, L, Cameron, E, and Neil, JC (2007) Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas. Cancer Research, 67 . pp. 5126-5133. (doi:10.1158/0008-5472.CAN-07-0433)

2006

Dunham, S.P., Bruce, J., MacKay, S., Golder, M., Jarrett, O., and Neil, J.C. (2006) Limited efficacy of an inactivated feline immunodeficiency virus vaccine. Veterinary Record, 158 (16). pp. 561-562. ISSN 0042-4900 (doi:10.1136/vr.158.16.561)

Blyth, K, Vaillant, F, Hanlon, L, Mackay, N, Bell, M, Jenkins, A, Neil, JC, and Cameron, ER (2006) Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo. Cancer Research, 66 . pp. 2195-2201. (doi:10.1158/0008-5472.CAN-05-3558)

Dunham, SP, Bruce, J, Klein, D, Flynn, JN, Golder, MC, MacDonald, S, Jarrett, O, and Neil, JC (2006) Prime-boost vaccination using DNA and whole inactivated virus vaccines provides limited protection against virulent feline immunodeficiency virus. Vaccine, 24 . pp. 7095-7108. ISSN 0264-410X (doi:10.1016/j.vaccine.2006.07.001)

2005

Hosie, M.J. et al. (2005) Vaccination with an Inactivated Virulent Feline Immunodeficiency Virus Engineered to Express High Levels of Env. Journal of Virology, 79 (3). pp. 1954-1957. ISSN 0022-538X

Blyth, K, Cameron, ER, and Neil, JC (2005) The RUNX genes: Gain or loss of function in cancer. Nature Reviews Cancer, 5 . pp. 376-387. (doi:10.1038/nrc1607)

2004

Cameron, ER, and Neil, JC (2004) The Runx genes: lineage-specific oncogenes and tumor suppressors. Oncogene, 23 . pp. 4308-4314. (doi:10.1038/sj.onc.1207130)

Neil, J (2004) Nomenclature for Runt-related (RUNX) proteins. Oncogene, 23 (24). pp. 4209-4210.

Terry, A, Kilbey, A, Vaillant, F, Stewart, M, Jenkins, A, Cameron, E, and Neil, JC (2004) Conservation and expression of an alternative 3 ' exon of Runx2 encoding a novel proline-rich C-terminal domain. Gene, 336 . pp. 115-125. (doi:10.1016/j.gene.2004.04.015)

Wotton, SF, Blyth, K, Kilbey, A, Jenkins, A, Terry, A, Bernardin-Fried, F, Friedman, AD, Baxter, EW, Neil, JC, and Cameron, ER (2004) RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53. Oncogene, 23 . pp. 5476-5486. (doi:10.1038/sj.onc.1207729)

2003

Cameron, E.R., Blyth, K., Hanlon, L., Kilbey, A., Mackay, N., Stewart, M., Terry, A., Vaillant, F., Wotton, S., and Neil, J.C. (2003) The Runx genes as dominant oncogenes. Blood, Cells, Molecules and Diseases, 30 . pp. 194-200. ISSN 1079-9796 (doi:10.1016/S1079-9796(03)00031-7)

Fleischmann, C, Bevan, S, Neil, JC, Terry, A, and Houlston, RS (2003) Mutations in the candidate tumour suppressor gene FLJ12973 on chromosome 15q15 are rare in colorectal cancer. Cancer Letters, 196 . pp. 65-67. (doi:10.1016/S0304-3835(03)00160-5)

Hanlon, L, Barr, NI, Blyth, K, Stewart, M, Haviernik, P, Wolff, L, Weston, K, Cameron, ER, and Neil, JC (2003) Long-range effects of retroviral insertion on c-myb: Overexpression may be obscured by silencing during tumor growth in vitro. Journal of Virology, 77 . pp. 1059-1068. ISSN 0022-538X (doi:10.1128/JVI.77.2.1059-1068.2003)

2002

Beatty, J, Terry, A, MacDonald, J, Gault, E, Cevario, S, OBrien, SJ, Cameron, E, and Neil, JC (2002) Feline immunodeficiency virus integration in B-cell lymphoma identifies a candidate tumor suppressor gene on human chromosome 15q15. Cancer Research, 62 . pp. 7175-7180.

Haviernik, P., Festin, S.M., Opavsky, R., Koller, R.P., Barr, N.I., Neil, J.C., and Wolff, L. (2002) Linkage on chromosome 10 of several murine retroviral integration loci associated with leukaemia. Journal of General Virology, 83 (4). pp. 819-827. ISSN 0022-1317

Neil, JC, and Cameron, ER (2002) Retroviral insertion sites and cancer: Fountain of all knowledge? Cancer Cell, 2 . pp. 253-255.

Stewart, M, MacKay, N, Cameron, ER, and Neil, JC (2002) The common retroviral insertion locus Dsi1 maps 30 kilobases upstream of the P1 promoter of the murine Runx3/Cbfa3/Aml2 gene. Journal of Virology, 76 (9). pp. 4364-4369. ISSN 0022-538X (doi:10.1128/JVI.76.9.4364-4369.2002)

Vaillant, F, Blyth, K, Andrew, L, Neil, JC, and Cameron, ER (2002) Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selection. Journal of Immunology, 169 . pp. 2866-2874.

Wotton, S, Stewart, M, Blyth, K, Vaillant, F, Kilbey, A, Neil, JC, and Cameron, ER (2002) Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma. Cancer Research, 62 . pp. 7181-7185.

2001

Baxter, EW, Blyth, K, Cameron, ER, and Neil, JC (2001) Selection for loss of p53 function in T-cell lymphomagenesis is alleviated by Moloney murine leukemia virus infection in myc transgenic mice. Journal of Virology, 75 . pp. 9790-9798. ISSN 0022-538X

Blyth, K, Terry, A, Mackay, N, Vaillant, F, Bell, M, Cameron, ER, Neil, JC, and Stewart, M (2001) Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging. Oncogene, 20 . pp. 295-302.

Hanlon, L et al. (2001) Feline leukemia virus DNA vaccine efficacy is enhanced by coadministration with interleukin-12 (IL-12) and IL-18 expression vectors. Journal of Virology, 75 . pp. 8424-8433. ISSN 0022-538X

1996

Hosie, M.J., Dunsford, T.H., de Ronde, A., Willett, B.J., Cannon, C.A., Neil, J.C., and Jarrett, O. (1996) Suppression of virus burden by immunization with feline immunodeficiency virus Env protein. Vaccine, 14 (5). pp. 405-411. ISSN 0264-410X (doi:10.1016/0264-410X(95)00193-5)

1995

Hosie, M.J., Osborne, R., Yamamoto, J.K., Neil, J.C., and Jarrett, O. (1995) Protection against homologous but not heterologous challenge induced by inactivated feline immunodeficiency virus vaccines. Journal of Virology, 69 (2). pp. 1253-1255. ISSN 0022-538X

1994

Flynn, J.N., Cannon, C.A., Beatty, J.A., Mackett, M., Rigby, M.A., Neil, J.C., and Jarrett, C. (1994) Induction of feline immunodeficiency virus-specific cytotoxic T cells in vivo with carrier-free synthetic peptide. Journal of Virology, 68 (9). pp. 5835-5844. ISSN 0022-538X

1988

McGeoch, D.J., Davison, A.J., and Neil, J.C. (1988) Some highlights of animal virus research in 1987. Journal of General Virology, 69 (10). pp. 2419-2440. ISSN 0022-1317 (doi:10.1099/0022-1317-69-10-2419)

This list was generated on Mon May 20 04:16:04 2013 BST.

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • New Approaches to Modelling Human Leukaemia
    Cancer Research UK
    2011 - 2013
     
  • New Approaches to Modelling Human Leukaemia
    Leukaemia & Lymphoma Research
    2011 - 2013
     
  • Centre for Integrated Virology
    MRC
    2010 - 2015
     
  • XENOME - Super-engineering of the porcine genome for xenotransplantation studies in primates: a step towards clinical application
    European Commission
    2006 - 2011
     
  • LRF/CRC Molecular Oncology Laboratory
    Leukaemia & Lymphoma Research
    2006 - 2010
     
  • The role of the runx gene family in neoplasia
    Cancer Research UK
    2006 - 2010
     
  • The Genetics and Biology of t-cell Lymphoma
    Cancer Research UK
    2004 - 2005
     
  • LRF/CRC Molecular Oncology Laboratory
    Leukaemia & Lymphoma Research
    2001 - 2005
     

Editorial Board

  • 2011 - ongoing: Frontiers in Molecular and Cellular Oncology

Grant Advisory Board

  • 2011 - ongoing: Heinrich Pette Institute, Hamburg - External Advisor, SAB
  • 2009 - 2009: National Cancer Institute, Frederick, USA - Site Visit
  • 2009 - 2010: BBSRC - Pool of Experts
  • 2008 - ongoing: Chronic Granulomatous Disease Research Trust - Advisory Group
  • 2007 - ongoing: Lady Tata Memorial Trust - Advisory Committee
  • 2007 - ongoing: INSERM (France) - Expert Panel
  • 2004 - 2005: European Medicines Agency - Expert Advisor
  • 2003 - 2008: Association for International Cancer Research - Scientific Advisory Committee
  • 1996 - 2005: Department of Health - The Gene Therapy Advisory Committee (GTAC)

Invited International Presentations

  • 2010: Annecy, France - Fondation Merieux Symposium 'New Trends in Tumor Virology'
  • 2010: Turku, Finland - Frontiers of Science Seminar Series
  • 2010: Hiroshima, Japan - International Runx Workshop
  • 2009: Oxford, UK - International Runx Workshop
  • 2008: Paris, France - Canceropole conference on animal models of cancer
  • 2008: Toronto, Canada - International Workshop on Retroviral Pathogenesis
  • 2008: Cape Cod, USA - International Runx Workshop
  • 2007: Singapore - International Runx Workshop
  • 2007: Freiburg, Germany - XXIII Symposium of the International Association for Comparative Research on Leukemia & Related Diseases
  • 2007: Vienna, Austria - International Workshop on Retroviral Pathogenesis
  • 2006: Gettysburg, USA - International Runx Workshop
  • 2006: Palm Springs, USA - International Workshop on Retroviral Pathogenesis
  • 2005: St Malo, France - International Workshop on Retroviral Pathogenesis
  • 2005: Heidelberg, Germany - XXII Symposium of the International Association for Comparative Research on Leukemia & Related Diseases (IACRLRD)
  • 2005: Crete, Greece - 8th International Symposium on Molecular Medicine

Professional Learned Society

  • 2011 - ongoing: Society of Biology - Fellow
  • 1997 - 2007: International Association for Research on Leukaemia & Related Diseases - World Committee
  • 1997 - ongoing: Royal Society of Edinburgh - Fellow