- Chair in Basic Immunology (Immunology)
RB424 Level B4
III - GBRC
Glasgow G12 8TA
Current Research :
Imaging Host & Parasite responses in vivo.
Much of what we understand about the anatomy and architecture of the immune system was revealed through exquisite experiments performed in the 1950’s to 70’s. These studies identified the role that anatomy played in a number of fundamental immunological phenomena including recirculation, induction of immune priming or tolerance and the interactions of T and B cells. The recent resurgence of interest in the role of immune architecture and anatomy in basic immunological and infectious phenomena is almost entirely due to technological developments in identifying and tracking cells and parasites in vivo, not least through the ability to do this dynamically, in real time through the application of multiphoton microscopy. We have recently established a state of the art, multiphoton microscope system at the University of Glasgow, which allows us to image on more channels, faster and deeper than previously possible. Our current studies apply multiphoton and other in vivo approaches to analyse immune priming and tolerance including studies in the context of Plasmodium and Trypanosome infection. This work provides a visual insight into host/parasite interactions and highlight the importance of early cellular dialogue in the development of adaptive immune responses. We also collaborate with physicists, mathematicians and chemists to continue development of new non-invasive, translational cell-imaging approaches.