Dr Fiona Achcar

  • Leverhulme Fellow (Parasitology)

telephone: 5276
email: Fiona.Achcar@glasgow.ac.uk

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • A new drug discovery pipeline for animal African trypanosomiasis
    Biotechnology and Biological Sciences Research Council
    2016 - 2019
     
  • A new drug discovery pipeline for animal African trypanosomiasis
    GALVmed
    2016 - 2019
     
  • Metabolic subversion in the interaction between leishmania and the macrophage
    Leverhulme Trust
    2015 - 2018
     
  • Mathematical modelling of the interaction between leishmania and the macrophage using omics data (ISSF Fellowships)
    Wellcome Trust
    2015 - 2015
     

Publications

List by: Type | Date

Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2009
Number of items: 13.

2015

Kim, D.-H., Achcar, F., Breitling, R. , Burgess, K. E. and Barrett, M. P. (2015) LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes. Metabolomics, 11(6), pp. 1721-1732. (doi:10.1007/s11306-015-0827-2) (PMID:26491423) (PMCID:PMC4605981)

Creek, D. J. et al. (2015) Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathogens, 11(3), e1004689. (doi:10.1371/journal.ppat.1004689) (PMID:25775470) (PMCID:PMC4361558)

Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi:10.1093/nar/gku944)

Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi:10.1093/nar/gku944) (PMID:25300491) (PMCID:PMC4384016)

2014

Achcar, F., Kerkhoven, E. J. and Barrett, M. P. (2014) Trypanosoma brucei: meet the system. Current Opinion in Microbiology, 20, pp. 162-169. (doi:10.1016/j.mib.2014.06.007)

Achcar, F. et al. (2014) The silicon trypanosome: a test case of iterative model extension in systems biology. Advances in Microbial Physiology, 64, pp. 115-143. (doi:10.1016/B978-0-12-800143-1.00003-8) (PMID:24797926) (PMCID:PMC4773886)

2013

Achcar, F., Barrett, M.P. and Breitling, R. (2013) Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis. FEBS Journal, 280(18), pp. 4640-4651. (doi:10.1111/febs.12436) (PMID:23865459) (PMCID:PMC4768353)

Breitling, R. , Achcar, F. and Takano, E. (2013) Modeling challenges in the synthetic biology of secondary metabolism. ACS Synthetic Biology, 2(7), pp. 373-378. (doi:10.1021/sb4000228)

Chokkathukalam, A., Jankevics, A., Creek, D.J., Achcar, F., Barrett, M.P. and Breitling, R. (2013) mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics, 29(2), pp. 281-283. (doi:10.1093/bioinformatics/bts674) (PMID:23162054) (PMCID:PMC3546800)

Kerkhoven, E. J. et al. (2013) Handling uncertainty in dynamic models: the pentose phosphate pathway in trypanosoma brucei. PLoS ONE, 9(12), e1003371. (doi:10.1371/journal.pcbi.1003371) (PMID:24339766) (PMCID:24339766)

2012

Achcar, F., Kerkhoven, E.J., SilicoTryp Consortium, , Bakker, B.M., Barrett, M.P. and Breitling, R. (2012) Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism. PLoS Computational Biology, 8(1), e1002352. (doi:10.1371/journal.pcbi.1002352)

2011

Achcar, F., Camadro, J.-M. and Mestivier, D. (2011) A Boolean probabilistic model of metabolic adaptation to oxygen in relation to iron homeostasis and oxidative stress. BMC Systems Biology, 5, 51. (doi:10.1186/1752-0509-5-51) (PMID:26050742) (PMCID:PMC4464606)

2009

Achcar, F., Camadro, J.-M. and Mestivier, D. (2009) AutoClass@IJM: a powerful tool for Bayesian classification of heterogeneous data in biology. Nucleic Acids Research, 37(Sup 2), W63-W67. (doi:10.1093/nar/gkp430) (PMID:19474346) (PMCID:PMC2703914)

This list was generated on Tue Sep 19 09:24:16 2017 BST.
Jump to: Articles
Number of items: 13.

Articles

Kim, D.-H., Achcar, F., Breitling, R. , Burgess, K. E. and Barrett, M. P. (2015) LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes. Metabolomics, 11(6), pp. 1721-1732. (doi:10.1007/s11306-015-0827-2) (PMID:26491423) (PMCID:PMC4605981)

Creek, D. J. et al. (2015) Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathogens, 11(3), e1004689. (doi:10.1371/journal.ppat.1004689) (PMID:25775470) (PMCID:PMC4361558)

Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi:10.1093/nar/gku944)

Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi:10.1093/nar/gku944) (PMID:25300491) (PMCID:PMC4384016)

Achcar, F., Kerkhoven, E. J. and Barrett, M. P. (2014) Trypanosoma brucei: meet the system. Current Opinion in Microbiology, 20, pp. 162-169. (doi:10.1016/j.mib.2014.06.007)

Achcar, F. et al. (2014) The silicon trypanosome: a test case of iterative model extension in systems biology. Advances in Microbial Physiology, 64, pp. 115-143. (doi:10.1016/B978-0-12-800143-1.00003-8) (PMID:24797926) (PMCID:PMC4773886)

Achcar, F., Barrett, M.P. and Breitling, R. (2013) Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis. FEBS Journal, 280(18), pp. 4640-4651. (doi:10.1111/febs.12436) (PMID:23865459) (PMCID:PMC4768353)

Breitling, R. , Achcar, F. and Takano, E. (2013) Modeling challenges in the synthetic biology of secondary metabolism. ACS Synthetic Biology, 2(7), pp. 373-378. (doi:10.1021/sb4000228)

Chokkathukalam, A., Jankevics, A., Creek, D.J., Achcar, F., Barrett, M.P. and Breitling, R. (2013) mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics, 29(2), pp. 281-283. (doi:10.1093/bioinformatics/bts674) (PMID:23162054) (PMCID:PMC3546800)

Kerkhoven, E. J. et al. (2013) Handling uncertainty in dynamic models: the pentose phosphate pathway in trypanosoma brucei. PLoS ONE, 9(12), e1003371. (doi:10.1371/journal.pcbi.1003371) (PMID:24339766) (PMCID:24339766)

Achcar, F., Kerkhoven, E.J., SilicoTryp Consortium, , Bakker, B.M., Barrett, M.P. and Breitling, R. (2012) Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism. PLoS Computational Biology, 8(1), e1002352. (doi:10.1371/journal.pcbi.1002352)

Achcar, F., Camadro, J.-M. and Mestivier, D. (2011) A Boolean probabilistic model of metabolic adaptation to oxygen in relation to iron homeostasis and oxidative stress. BMC Systems Biology, 5, 51. (doi:10.1186/1752-0509-5-51) (PMID:26050742) (PMCID:PMC4464606)

Achcar, F., Camadro, J.-M. and Mestivier, D. (2009) AutoClass@IJM: a powerful tool for Bayesian classification of heterogeneous data in biology. Nucleic Acids Research, 37(Sup 2), W63-W67. (doi:10.1093/nar/gkp430) (PMID:19474346) (PMCID:PMC2703914)

This list was generated on Tue Sep 19 09:24:16 2017 BST.