Dr Esther Schnettler

  • Affiliate (Centre for Virus Research)

Research interests

CVR logo

Arboviruses are transmitted by biting arthropods (e.g. mosquitoes, ticks and midges) to mammals (including humans) and can cause severe disease. Important arboviruses affecting humans and life stocks are the mosquito-borne chikungunya virus, dengue virus, Rift valley fever virus; the midge-borne Schmallenberg virus, Bluetongue virus and the tick-borne Crimean Congo haemorrhagic fever virus and tick borne encephalitis virus.

Arboviral infections in vertebrate cells result in strong cytophatic effects. In sharp contrast, in arthropod cells persistent, non-cytopathic infections are usually observed, most likely due to an effective innate immune response.

The aim of my work is to further understand the interaction of arboviruses with their vector innate immune responses, particularly the RNAi machinery. At the moment, I am focusing on the mosquito arbovirus vector, but I am also interested in the tick and midge arbovirus vector. The findings will extend our knowledge on the interactions between virus and arthropod vector, and will be important for further research in the field including the development of novel prevention strategies.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • The emergence of Zika virus in Brazil: investigating prevalence and host responses to design preventive strategies
    Medical Research Council
    2016 - 2019
     
  • MAPP
    European Commission
    2015 - 2017
     

Publications

List by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2012 | 2010 | 2009
Number of items: 23.

2016

Pingen, M., Bryden, S. R., Pondeville, E., Schnettler, E., Kohl, A., Merits, A., Fazakerley, J. K., Graham, G. J., and McKimmie, C. S. (2016) Host inflammatory response to mosquito bites enhances the severity of arbovirus infection. Immunity, 44(6), pp. 1455-1469. (doi:10.1016/j.immuni.2016.06.002)

Rainey, S. M. et al. (2016) Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways. PLoS Pathogens, 12(4), e1005536. (doi:10.1371/journal.ppat.1005536) (PMID:27089431)

Hover, S. et al. (2016) Modulation of potassium channels inhibits bunyavirus infection. Journal of Biological Chemistry, (doi:10.1074/jbc.M115.692673) (PMID:26677217)

Kohl, A. et al. (2016) Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements. Pathogens and Global Health, (Accepted for Publication)

Wijayanti, S. P. M., Sunaryo, S., Suprihatin, S., McFarlane, M., Rainey, S. M., Dietrich, I., Schnettler, E., Biek, R., and Kohl, A. (2016) Dengue in Java, Indonesia: relevance of mosquito indices as risk predictors. PLoS Neglected Tropical Diseases, 10(3), e0004500. (doi:10.1371/journal.pntd.0004500) (PMID:26967524)

2015

Lu, Y., McGavin, W., Cock, P. J. A., Schnettler, E., Yan, F., Chen, J., and MacFarlane, S. (2015) Newly identified RNAs of raspberry leaf blotch virus encoding a related group of proteins. Journal of General Virology, 96(11), pp. 3432-3439. (doi:10.1099/jgv.0.000277) (PMID:26358478)

Blomström, A.-L. et al. (2015) Transcriptome analysis reveals the host response to Schmallenberg virus in bovine cells and antagonistic effects of the NSs protein. BMC Genomics, 16, 324. (doi:10.1186/s12864-015-1538-9) (PMID:25896169) (PMCID:PMC4404599)

Brennan, B. et al. (2015) In memoriam – Richard M. Elliott (1954–2015). Journal of General Virology, 96(8), pp. 1975-1978. (doi:10.1099/jgv.0.000241) (PMID:26315040)

Kean, J., Rainey, S., McFarlane, M., Donald, C., Schnettler, E., Kohl, A., and Pondeville, E. (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi:10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

2014

Barry, G. et al. (2014) NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery. Journal of General Virology, 95(Pt. 8), pp. 1640-1646. (doi:10.1099/vir.0.065425-0)

McFarlane, M. et al. (2014) Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication. PLoS Neglected Tropical Diseases, 8(7), e2994. (doi:10.1371/journal.pntd.0002994) (PMID:25058001) (PMCID:PMC4109886)

Schnettler, E. et al. (2014) Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses. Nucleic Acids Research, 42(14), pp. 9436-9446. (doi:10.1093/nar/gku657)

2013

Watson, M., Schnettler, E., and Kohl, A. (2013) viRome: an R package for the visualization and analysis of viral small RNA sequence datasets. Bioinformatics, 29(15), pp. 1902-1903. (doi:10.1093/bioinformatics/btt297) (PMID:23709497) (PMCID:PMC3712215)

Schnettler, E., Donald, C. L., Human, S., Watson, M., Siu, R. W. C., McFarlane, M., Fazakerley, J. K., Kohl, A., and Fragkoudis, R. (2013) Knockdown of piRNA pathway proteins results in enhanced Semliki forest virus production in mosquito cells. Journal of General Virology, 94(Pt. 7), pp. 1680-1689. (doi:10.1099/vir.0.053850-0) (PMID:23559478) (PMCID:PMC3709635)

Barry, G., Alberdi, P., Schnettler, E., Weisheit, S., Kohl, A., Fazakerley, J.K., and Bell-Sakyi, L. (2013) Gene silencing in tick cell lines using small interfering or long double-stranded RNA. Experimental and Applied Acarology, 59(3), pp. 319-338. (doi:10.1007/s10493-012-9598-x)

Schnettler, E., Ratinier, M., Watson, M., Shaw, A. E., McFarlane, M., Varela, M., Elliott, R. M., Palmarini, M., and Kohl, A. (2013) RNA interference targets arbovirus replication in Culicoides cells. Journal of Virology, 87(5), pp. 2441-2454. (doi:10.1128/JVI.02848-12) (PMID:23269795) (PMCID:PMC3571378)

Eifan, S., Schnettler, E., Dietrich, I., Kohl, A., and Blomstrom, A. (2013) Non-structural proteins of arthropod-borne bunyaviruses: roles and functions. Viruses, 5(10), pp. 2447-2468. (doi:10.3390/v5102447)

Varela, M. et al. (2013) Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host. PLoS Pathogens, 9(1), e1003133. (doi:10.1371/journal.ppat.1003133) (PMID:23326235) (PMCID:PMC3542112)

2012

Schnettler, E., Sterken, M. G., Leung, J. Y., Metz, S. W., Geertsema, C., Goldbach, R. W., Vlak, J. M., Kohl, A., Khromykh, A. A.., and Pijlman, G. P. (2012) Noncoding flavivirus RNA displays RNA interference suppressor activity in insect and mammalian cells. Journal of Virology, 86(24), pp. 13486-13500. (doi:10.1128/JVI.01104-12) (PMID:23035235) (PMCID:PMC3503047)

Donald, C. L., Kohl, A., and Schnettler, E. (2012) New insights into control of arbovirus replication and spread by insect RNA interference pathways. Insects, 3(2), pp. 511-531. (doi:10.3390/insects3020511)

Rodriguez-Andres, J. et al. (2012) Phenoloxidase activity acts as a mosquito innate immune response against infection with semliki forest virus. PLoS Pathogens, 8(11), e1002977. (doi:10.1371/journal.ppat.1002977) (PMID:23144608) (PMCID:PMC3493465)

2010

Schnettler, E., Hemmes, H., Huismann, R., Goldbach, R., Prins, M., and Kormelink, R. (2010) Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules. Journal of Virology, 84(21), pp. 11542-11554. (doi:10.1128/JVI.00595-10)

2009

Schnettler, E., de Vries, W., Hemmes, H., Haasnoot, J., Kormelink, R., Goldbach, R., and Berkhout, B. (2009) The NS3 protein of rice hoja blanca virus complements the RNAi suppressor function of HIV-1 Tat. EMBO Reports, 10(3), pp. 258-263. (doi:10.1038/embor.2009.6)

This list was generated on Mon Jul 25 04:44:05 2016 BST.
Jump to: Articles
Number of items: 23.

Articles

Pingen, M., Bryden, S. R., Pondeville, E., Schnettler, E., Kohl, A., Merits, A., Fazakerley, J. K., Graham, G. J., and McKimmie, C. S. (2016) Host inflammatory response to mosquito bites enhances the severity of arbovirus infection. Immunity, 44(6), pp. 1455-1469. (doi:10.1016/j.immuni.2016.06.002)

Rainey, S. M. et al. (2016) Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways. PLoS Pathogens, 12(4), e1005536. (doi:10.1371/journal.ppat.1005536) (PMID:27089431)

Hover, S. et al. (2016) Modulation of potassium channels inhibits bunyavirus infection. Journal of Biological Chemistry, (doi:10.1074/jbc.M115.692673) (PMID:26677217)

Kohl, A. et al. (2016) Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements. Pathogens and Global Health, (Accepted for Publication)

Wijayanti, S. P. M., Sunaryo, S., Suprihatin, S., McFarlane, M., Rainey, S. M., Dietrich, I., Schnettler, E., Biek, R., and Kohl, A. (2016) Dengue in Java, Indonesia: relevance of mosquito indices as risk predictors. PLoS Neglected Tropical Diseases, 10(3), e0004500. (doi:10.1371/journal.pntd.0004500) (PMID:26967524)

Lu, Y., McGavin, W., Cock, P. J. A., Schnettler, E., Yan, F., Chen, J., and MacFarlane, S. (2015) Newly identified RNAs of raspberry leaf blotch virus encoding a related group of proteins. Journal of General Virology, 96(11), pp. 3432-3439. (doi:10.1099/jgv.0.000277) (PMID:26358478)

Blomström, A.-L. et al. (2015) Transcriptome analysis reveals the host response to Schmallenberg virus in bovine cells and antagonistic effects of the NSs protein. BMC Genomics, 16, 324. (doi:10.1186/s12864-015-1538-9) (PMID:25896169) (PMCID:PMC4404599)

Brennan, B. et al. (2015) In memoriam – Richard M. Elliott (1954–2015). Journal of General Virology, 96(8), pp. 1975-1978. (doi:10.1099/jgv.0.000241) (PMID:26315040)

Kean, J., Rainey, S., McFarlane, M., Donald, C., Schnettler, E., Kohl, A., and Pondeville, E. (2015) Fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes. Insects, 6(1), pp. 236-278. (doi:10.3390/insects6010236) (PMID:26463078) (PMCID:PMC4553541)

Barry, G. et al. (2014) NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery. Journal of General Virology, 95(Pt. 8), pp. 1640-1646. (doi:10.1099/vir.0.065425-0)

McFarlane, M. et al. (2014) Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication. PLoS Neglected Tropical Diseases, 8(7), e2994. (doi:10.1371/journal.pntd.0002994) (PMID:25058001) (PMCID:PMC4109886)

Schnettler, E. et al. (2014) Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses. Nucleic Acids Research, 42(14), pp. 9436-9446. (doi:10.1093/nar/gku657)

Watson, M., Schnettler, E., and Kohl, A. (2013) viRome: an R package for the visualization and analysis of viral small RNA sequence datasets. Bioinformatics, 29(15), pp. 1902-1903. (doi:10.1093/bioinformatics/btt297) (PMID:23709497) (PMCID:PMC3712215)

Schnettler, E., Donald, C. L., Human, S., Watson, M., Siu, R. W. C., McFarlane, M., Fazakerley, J. K., Kohl, A., and Fragkoudis, R. (2013) Knockdown of piRNA pathway proteins results in enhanced Semliki forest virus production in mosquito cells. Journal of General Virology, 94(Pt. 7), pp. 1680-1689. (doi:10.1099/vir.0.053850-0) (PMID:23559478) (PMCID:PMC3709635)

Barry, G., Alberdi, P., Schnettler, E., Weisheit, S., Kohl, A., Fazakerley, J.K., and Bell-Sakyi, L. (2013) Gene silencing in tick cell lines using small interfering or long double-stranded RNA. Experimental and Applied Acarology, 59(3), pp. 319-338. (doi:10.1007/s10493-012-9598-x)

Schnettler, E., Ratinier, M., Watson, M., Shaw, A. E., McFarlane, M., Varela, M., Elliott, R. M., Palmarini, M., and Kohl, A. (2013) RNA interference targets arbovirus replication in Culicoides cells. Journal of Virology, 87(5), pp. 2441-2454. (doi:10.1128/JVI.02848-12) (PMID:23269795) (PMCID:PMC3571378)

Eifan, S., Schnettler, E., Dietrich, I., Kohl, A., and Blomstrom, A. (2013) Non-structural proteins of arthropod-borne bunyaviruses: roles and functions. Viruses, 5(10), pp. 2447-2468. (doi:10.3390/v5102447)

Varela, M. et al. (2013) Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host. PLoS Pathogens, 9(1), e1003133. (doi:10.1371/journal.ppat.1003133) (PMID:23326235) (PMCID:PMC3542112)

Schnettler, E., Sterken, M. G., Leung, J. Y., Metz, S. W., Geertsema, C., Goldbach, R. W., Vlak, J. M., Kohl, A., Khromykh, A. A.., and Pijlman, G. P. (2012) Noncoding flavivirus RNA displays RNA interference suppressor activity in insect and mammalian cells. Journal of Virology, 86(24), pp. 13486-13500. (doi:10.1128/JVI.01104-12) (PMID:23035235) (PMCID:PMC3503047)

Donald, C. L., Kohl, A., and Schnettler, E. (2012) New insights into control of arbovirus replication and spread by insect RNA interference pathways. Insects, 3(2), pp. 511-531. (doi:10.3390/insects3020511)

Rodriguez-Andres, J. et al. (2012) Phenoloxidase activity acts as a mosquito innate immune response against infection with semliki forest virus. PLoS Pathogens, 8(11), e1002977. (doi:10.1371/journal.ppat.1002977) (PMID:23144608) (PMCID:PMC3493465)

Schnettler, E., Hemmes, H., Huismann, R., Goldbach, R., Prins, M., and Kormelink, R. (2010) Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules. Journal of Virology, 84(21), pp. 11542-11554. (doi:10.1128/JVI.00595-10)

Schnettler, E., de Vries, W., Hemmes, H., Haasnoot, J., Kormelink, R., Goldbach, R., and Berkhout, B. (2009) The NS3 protein of rice hoja blanca virus complements the RNAi suppressor function of HIV-1 Tat. EMBO Reports, 10(3), pp. 258-263. (doi:10.1038/embor.2009.6)

This list was generated on Mon Jul 25 04:44:05 2016 BST.

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