Dr Benjamin Hale

  • Sir Henry Dale Fellow/ Lecturer (Centre for Virus Research)

Research interests

Influenza viruses are globally important pathogens that cause a significant seasonal disease burden. The ability of influenza viruses to infect many animal species also contributes to the ever-present threat of a novel strain starting a new human pandemic, with potentially devastating consequences. Some vaccines and antivirals are currently available for the prevention and treatment of influenza, however it often takes too long to manufacture, distribute, and administer an effective strain-matched vaccine under pandemic circumstances. In addition, influenza viruses mutate very rapidly and drug-resistant mutants often emerge against currently approved antivirals.

The aim of my work is to understand fundamental host cell processes that modulate replication of human, swine, and avian influenza viruses. This could establish an intellectual framework for the development of new host-orientated intervention strategies. By targeting cellular pathways, the issue of rapid viral resistance arising should be heavily diminished.

I am particularly interested in trying to understand the intricate virus-host interplay that occurs within cellular signalling response cascades as invading influenza viruses attempt to 're-wire their new homes'. I aim to integrate cellular, molecular, and structural approaches to understand how such interactions affect virus replication/virulence, and perhaps to reveal new insights into normal cell biology by studying viral hijacking strategies. One particular interest is host phosphoinositide 3-kinase (PI3K), a druggable survival-signalling enzyme that is deregulated in many human cancers, and which is uniquely and exquisitely activated by the influenza A virus NS1 protein virulence factor. Another major focus of my group is a developing programme to catalogue the spectrum of signalling events associated with ubiquitin and ubiquitin-like (e.g. SUMO) modification during influenza virus infection.

 

MRC - University of Glasgow Centre for Virus Research

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Interplay between influenza viruses and host SUMO pathways
    European Research Council
    2014 - 2019
     
  • Interplay between influenza viruses and host ubiquitin signalling
    Wellcome Trust
    2013 - 2018
     
  • UBIFLU: Ubiquitin Signalling Pathways Required for Influenza Virus Replication: Biological Characterisation and Identification of Novel Drug Targets
    European Commission
    2012 - 2016
     

Publications

List by: Type | Date

Jump to: 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006
Number of items: 21.

2014

Ayllon, J., Domingues, P., Rajsbaum, R., Miorin, L., Schmolke, M., Hale, B. G., and Garcia-Sastre, A. (2014) A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence. Journal of Virology, 88 (20). pp. 12146-12151. ISSN 0022-538X (doi:10.1128/JVI.01567-14)

2013

Everett, R.D., Boutell, C., and Hale, B.G. (2013) Interplay between viruses and host sumoylation pathways. Nature Reviews Microbiology, 11 (6). pp. 400-411. ISSN 1740-1526 (doi:10.1038/nrmicro3015)

Zhang, H., Hale, B.G., Xu, K., and Sun, B. (2013) Viral and host factors required for avian H5N1 influenza A virus replication in mammalian cells. Viruses, 5 (6). pp. 1431-1446. ISSN 1999-4915 (doi:10.3390/v5061431)

2012

Ayllon, J., Russell, R.J., García-Sastre, A., and Hale, B.G. (2012) Contribution of NS1 effector domain dimerization to influenza A virus replication and virulence. Journal of Virology, 86 (23). pp. 13095-13098. ISSN 0022-538X (doi:10.1128/JVI.02237-12 )

Ayllon, J., Hale, B.G., and Garcia-Sastre, A. (2012) Strain-specific contribution of NS1-activated phosphoinositide 3-kinase signaling to influenza a virus replication and virulence. Journal of Virology, 86 (9). pp. 5366-5370. ISSN 0022-538X (doi:10.1128/JVI.06722-11)

Noronha, J.M. et al. (2012) Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction. Journal of Virology, 86 (10). pp. 5857-5866. ISSN 0022-538X (doi:10.1128/JVI.06901-11 )

Ayllon, J., García-Sastre, A., and Hale, B.G. (2012) Influenza A viruses and PI3K: are there time, place and manner restrictions? Virulence, 3 (4). pp. 411-414. ISSN 2150-5594 (doi:10.4161/viru.20932)

2011

Schmolke, M., Manicassamy, B., Pena, L., Sutton, T., Hai, R., Varga, Z.T., Hale, B.G., Steel, J., Pérez, D.R., and García-Sastre, A. (2011) Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species. PLoS Pathogens, 7 (8). e1002186. ISSN 1553-7366 (doi:10.1371/journal.ppat.1002186)

Kerry, P.S., Ayllon, J., Taylor, M.A., Hass, C., Lewis, A., García-Sastre, A., Randall, R.E., Hale, B.G., and Russell, R.J. (2011) A transient homotypic interaction model for the influenza A virus NS1 protein effector domain. PLoS ONE, 6 (3). e17946. ISSN 1932-6203 (doi:10.1371/journal.pone.0017946)

2010

Hale, B.G., Steel, J., Manicassamy, B., Medina, R.A., Ye, J., Hickman, D., Lowen, A.C., Perez, D.R., and Garcia-Sastre, A. (2010) Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus. Journal of General Virology, 91 (7). pp. 1737-1742. ISSN 0022-1317 (doi:10.1099/vir.0.020925-0)

Hale, B.G. et al. (2010) Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein. Journal of Virology, 84 (14). pp. 6909-6922. ISSN 0022-538X (doi:10.1128/JVI.00081-10)

Versteeg, G.A., Hale, B.G., van Boheemen, S., Wolff, T., Lenschow, D.J., and García-Sastre, A. (2010) Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein. Journal of Virology, 84 (10). pp. 5423-5430. ISSN 0022-538X (doi:10.1128/​JVI.02395-09)

Hale, B.G., Kerry, P.S., Jackson, D., Precious, B.L., Gray, A., Killip, M.J., Randall, R.E., and Russell, R.J. (2010) Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein. Proceedings of the National Academy of Sciences of the United States of America, 107 (5). pp. 1954-1959. ISSN 0027-8424 (doi:10.1073/pnas.0910715107)

Hale, B.G., Albrecht, R.A., and García-Sastre, A. (2010) Innate immune evasion strategies of influenza viruses. Future Microbiology, 5 (1). pp. 23-41. ISSN 1746-0913 (doi:10.2217/fmb.09.108)

2009

Gallacher, M., Brown, S.G., Hale, B.G., Fearns, R., Olver, R.E., Randall, R.E., and Wilson, S.M. (2009) Cation currents in human airway epithelial cells induced by infection with influenza A virus. Journal of Physiology, 587 (13). pp. 3159-3173. ISSN 0022-3751 (doi:10.1113/jphysiol.2009.171223)

Hale, B.G., Knebel, A., Botting, C.H., Galloway, C.S., Precious, B.L., Jackson, D., Elliott, R.M., and Randall, R.E. (2009) CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215. Virology, 383 (1). pp. 6-11. ISSN 0042-6822 (doi:10.1016/j.virol.2008.10.002)

2008

Hale, B.G., Randall, R.E., Ortin, J., and Jackson, D. (2008) The multifunctional NS1 protein of influenza A viruses. Journal of General Virology, 89 (10). 2359-2376 . ISSN 0022-1317 (doi:10.1099/vir.0.2008/004606-0 )

Hale, B.G., Barclay, W.S., Randall, R.E., and Russell, R.J. (2008) Structure of an avian influenza A virus NS1 protein effector domain. Virology, 378 (1). pp. 1-5. ISSN 0042-6822 (doi:10.1016/j.virol.2008.05.026)

Hale, B.G., Batty, I.H., Downes, C.P., and Randall, R.E. (2008) Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85beta suggests a novel mechanism for phosphoinositide 3-kinase activation. Journal of Biological Chemistry, 283 (3). pp. 1372-1380. ISSN 0021-9258 (doi:10.1074/jbc.M708862200)

2007

Hale, B.G., and Randall, R.E. (2007) PI3K signalling during influenza A virus infections. Biochemical Society Transactions, 35 (2). pp. 186-187. ISSN 0300-5127 (doi:10.1042/BST0350186)

2006

Hale, B. G., Jackson, D., Chen, Y.-H., Lamb, R.A., and Randall, R.E. (2006) Influenza A virus NS1 protein binds p85β and activates phosphatidylinositol-3-kinase signaling. Proceedings of the National Academy of Sciences of the United States of America, 103 (38). pp. 14194-9. ISSN 0027-8424 (doi:10.1073/pnas.0606109103 )

This list was generated on Fri Nov 21 22:06:56 2014 GMT.
Jump to: Articles
Number of items: 21.

Articles

Ayllon, J., Domingues, P., Rajsbaum, R., Miorin, L., Schmolke, M., Hale, B. G., and Garcia-Sastre, A. (2014) A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence. Journal of Virology, 88 (20). pp. 12146-12151. ISSN 0022-538X (doi:10.1128/JVI.01567-14)

Everett, R.D., Boutell, C., and Hale, B.G. (2013) Interplay between viruses and host sumoylation pathways. Nature Reviews Microbiology, 11 (6). pp. 400-411. ISSN 1740-1526 (doi:10.1038/nrmicro3015)

Zhang, H., Hale, B.G., Xu, K., and Sun, B. (2013) Viral and host factors required for avian H5N1 influenza A virus replication in mammalian cells. Viruses, 5 (6). pp. 1431-1446. ISSN 1999-4915 (doi:10.3390/v5061431)

Ayllon, J., Russell, R.J., García-Sastre, A., and Hale, B.G. (2012) Contribution of NS1 effector domain dimerization to influenza A virus replication and virulence. Journal of Virology, 86 (23). pp. 13095-13098. ISSN 0022-538X (doi:10.1128/JVI.02237-12 )

Ayllon, J., Hale, B.G., and Garcia-Sastre, A. (2012) Strain-specific contribution of NS1-activated phosphoinositide 3-kinase signaling to influenza a virus replication and virulence. Journal of Virology, 86 (9). pp. 5366-5370. ISSN 0022-538X (doi:10.1128/JVI.06722-11)

Noronha, J.M. et al. (2012) Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction. Journal of Virology, 86 (10). pp. 5857-5866. ISSN 0022-538X (doi:10.1128/JVI.06901-11 )

Ayllon, J., García-Sastre, A., and Hale, B.G. (2012) Influenza A viruses and PI3K: are there time, place and manner restrictions? Virulence, 3 (4). pp. 411-414. ISSN 2150-5594 (doi:10.4161/viru.20932)

Schmolke, M., Manicassamy, B., Pena, L., Sutton, T., Hai, R., Varga, Z.T., Hale, B.G., Steel, J., Pérez, D.R., and García-Sastre, A. (2011) Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species. PLoS Pathogens, 7 (8). e1002186. ISSN 1553-7366 (doi:10.1371/journal.ppat.1002186)

Kerry, P.S., Ayllon, J., Taylor, M.A., Hass, C., Lewis, A., García-Sastre, A., Randall, R.E., Hale, B.G., and Russell, R.J. (2011) A transient homotypic interaction model for the influenza A virus NS1 protein effector domain. PLoS ONE, 6 (3). e17946. ISSN 1932-6203 (doi:10.1371/journal.pone.0017946)

Hale, B.G., Steel, J., Manicassamy, B., Medina, R.A., Ye, J., Hickman, D., Lowen, A.C., Perez, D.R., and Garcia-Sastre, A. (2010) Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus. Journal of General Virology, 91 (7). pp. 1737-1742. ISSN 0022-1317 (doi:10.1099/vir.0.020925-0)

Hale, B.G. et al. (2010) Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein. Journal of Virology, 84 (14). pp. 6909-6922. ISSN 0022-538X (doi:10.1128/JVI.00081-10)

Versteeg, G.A., Hale, B.G., van Boheemen, S., Wolff, T., Lenschow, D.J., and García-Sastre, A. (2010) Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein. Journal of Virology, 84 (10). pp. 5423-5430. ISSN 0022-538X (doi:10.1128/​JVI.02395-09)

Hale, B.G., Kerry, P.S., Jackson, D., Precious, B.L., Gray, A., Killip, M.J., Randall, R.E., and Russell, R.J. (2010) Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein. Proceedings of the National Academy of Sciences of the United States of America, 107 (5). pp. 1954-1959. ISSN 0027-8424 (doi:10.1073/pnas.0910715107)

Hale, B.G., Albrecht, R.A., and García-Sastre, A. (2010) Innate immune evasion strategies of influenza viruses. Future Microbiology, 5 (1). pp. 23-41. ISSN 1746-0913 (doi:10.2217/fmb.09.108)

Gallacher, M., Brown, S.G., Hale, B.G., Fearns, R., Olver, R.E., Randall, R.E., and Wilson, S.M. (2009) Cation currents in human airway epithelial cells induced by infection with influenza A virus. Journal of Physiology, 587 (13). pp. 3159-3173. ISSN 0022-3751 (doi:10.1113/jphysiol.2009.171223)

Hale, B.G., Knebel, A., Botting, C.H., Galloway, C.S., Precious, B.L., Jackson, D., Elliott, R.M., and Randall, R.E. (2009) CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215. Virology, 383 (1). pp. 6-11. ISSN 0042-6822 (doi:10.1016/j.virol.2008.10.002)

Hale, B.G., Randall, R.E., Ortin, J., and Jackson, D. (2008) The multifunctional NS1 protein of influenza A viruses. Journal of General Virology, 89 (10). 2359-2376 . ISSN 0022-1317 (doi:10.1099/vir.0.2008/004606-0 )

Hale, B.G., Barclay, W.S., Randall, R.E., and Russell, R.J. (2008) Structure of an avian influenza A virus NS1 protein effector domain. Virology, 378 (1). pp. 1-5. ISSN 0042-6822 (doi:10.1016/j.virol.2008.05.026)

Hale, B.G., Batty, I.H., Downes, C.P., and Randall, R.E. (2008) Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85beta suggests a novel mechanism for phosphoinositide 3-kinase activation. Journal of Biological Chemistry, 283 (3). pp. 1372-1380. ISSN 0021-9258 (doi:10.1074/jbc.M708862200)

Hale, B.G., and Randall, R.E. (2007) PI3K signalling during influenza A virus infections. Biochemical Society Transactions, 35 (2). pp. 186-187. ISSN 0300-5127 (doi:10.1042/BST0350186)

Hale, B. G., Jackson, D., Chen, Y.-H., Lamb, R.A., and Randall, R.E. (2006) Influenza A virus NS1 protein binds p85β and activates phosphatidylinositol-3-kinase signaling. Proceedings of the National Academy of Sciences of the United States of America, 103 (38). pp. 14194-9. ISSN 0027-8424 (doi:10.1073/pnas.0606109103 )

This list was generated on Fri Nov 21 22:06:56 2014 GMT.