Dr Ashley Miller

Dr Ashley M Miller
  • Leadership Fellow (Institute of Cardiovascular and Medical Sciences)

email: Ashley.Miller@glasgow.ac.uk


The focus of my research is to investigate the role of inflammation in cardiovascular disease, particularly in atherosclerosis and obesity. The concept that atherosclerosis is a chronic inflammatory disease of the arterial wall is well established and I am interested in the growing number of novel IL-1 family cytokines that have been identified as critical regulators of inflammatory responses and CD4+ T cell differentiation. I have shown that the IL-1 family cytokine, IL-33, and its receptor ST2 can play a key protective role in systemic and vascular inflammation by polarizing CD4+ immune responses towards a Th2 profile (Miller et al, J Exp Med 2008). More recently, I demonstrated that IL-33 exerts protective metabolic effects during obesity in mice (Miller et al, Circ Res 2010) by inducing accumulation of Th2 cells in adipose tissue and polarization of adipose tissue macrophages towards an M2 alternatively activated phenotype (CD206+), a lineage associated with protection against obesity-related metabolic events. 

A second focus is study of the role of microRNA regulation of inflammatory cells in obesity. Chronic low-grade inflammation involving adipose tissue and liver likely contributes to metabolic consequences of obesity such as type 2 diabetes (T2D). It is becoming increasingly apparent that in order to improve clinical intervention, a better understanding of regulatory mechanisms controlling inflammatory cells in metabolic tissues is required. MicroRNAs are emerging as key regulators of macrophage lipid metabolism within adipose tissue and liver and I am currently studying the role of several miRNA during obesity.

 

Jump to: 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2002 | 2001 | 1998
Number of items: 35.

2013

Bradshaw, A.C., Coughlan, L., Miller, A.M., Nicklin, S.A., and Baker, A.H. (2013) Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses. Journal of Controlled Release, 164 (3). pp. 394-402. ISSN 0168-3659 (doi:10.1016/j.jconrel.2012.05.025)

Weir, R.A.P. et al. (2013) Galectin-3 and cardiac function in survivors of acute myocardial infarction. Circulation: Heart Failure, 6 (3). pp. 492-498. ISSN 1941-3289 (doi:10.1161/CIRCHEARTFAILURE.112.000146)

2012

Weir, R.A.P., Miller, A.M., Petrie, C.J., Clements, S., Steedman, T., Dargie, H.J., Squire, I.B., Ng, L.L., McInnes, I.B., and McMurray, J.J.V. (2012) Interleukin-21 – a biomarker of importance in predicting myocardial function following acute infarction? Cytokine, 60 (1). pp. 220-225. ISSN 1043-4666 (doi:10.1016/j.cyto.2012.06.002)

Caporali, A. et al. (2012) Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia. Arteriosclerosis, Thrombosis and Vascular Biology, 32 (12). e149-e160. ISSN 1079-5642 (doi:10.1161/ATVBAHA.112.300497)

Frleta, M., King, V., Reilly, J.H., Gilchrist, D.S., Tornehave, D., Lundsgaard, D., Miller, A.M., and McInnes, I.B. (2012) Expression of IL-21 receptor in synovial tissue and blood of patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 71 (Sup. 1). A83. ISSN 0003-4967 (doi:10.1136/annrheumdis-2011-201238.25)

2011

Miller, A.M., and Liew, F.Y. (2011) The IL-33/ST2 pathway — A new therapeutic target in cardiovascular disease. Pharmacology and Therapeutics, 131 (2). pp. 179-186. ISSN 0163-7258 (doi:10.1016/j.pharmthera.2011.02.005)

Miller, A., and McInnes, I.B. (2011) Cytokines as Therapeutic Targets to Reduce Cardiovascular Risk in Chronic Inflammation. Current Pharmaceutical Design, 17 (1). pp. 1-8. ISSN 1381-6128 (doi:10.2174/138161211795049796)

Asquith, D.L., Miller, A.M., Reilly, J., Kerr, S., Welsh, P., Sattar, N., and McInnes, I.B. (2011) Simultaneous activation of the liver X receptors (LXR and LXR ) drives murine collagen-induced arthritis disease pathology. Annals of the Rheumatic Diseases, 70 (12). pp. 2225-2228. ISSN 0003-4967 (doi:10.1136/ard.2011.152652)

Hueber, A.J., Alves-Filho, J.C., Asquith, D.L., Michels, C., Millar, N.L., Reilly, J.H., Graham, G., Liew, F.Y., Miller, A.M., and McInnes, I.B. (2011) IL-33 induces skin inflammation with mast cell and neutrophil activation. European Journal of Immunology, 41 (8). pp. 2229-2237. ISSN 0014-2980 (doi:10.1002/eji.201041360)

Miller, A.M. (2011) Role of IL-33 in inflammation and disease. Journal of Inflammation, 8 (1). p. 22. ISSN 1476-9255 (doi:10.1186/1476-9255-8-22)

2010

Alba, R. et al. (2010) Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. Blood, 14 (116). pp. 2656-2664. ISSN 0006-4971 (doi:10.1182/blood-2009-12-260026)

Weir, R.A.P., Miller, A.M., Murphy, G., Clements, S., Steedman, T., Connell, J., McInnes, I., Dargie, H., and McMurray, J.J. (2010) Serum soluble ST2 a potential novel mediator in left ventricular and infarct remodeling after acute myocardial infarction. Journal of the American College of Cardiology, 55 (3). pp. 243-250. ISSN 0735-1097 (doi:10.1016/j.jacc.2009.08.047)

Asquith, D.L., Miller, A.M., Hueber, A.J., Liew, F.Y., Sattar, N., and McInnes, I.B. (2010) Apolipoprotein E-deficient mice are resistant to the development of collagen-induced arthritis. Arthritis and Rheumatism, 62 (2). pp. 472-477. ISSN 0004-3591 (doi:10.1002/art.27205)

Hueber, A. J., Asquith, D. L., Miller, A.M., Reilly, J., Kerr, S., Leipe, J., Melendez Romero, A. J., and McInnes, I. B. (2010) Cutting Edge: Mast Cells Express IL-17A in Rheumatoid Arthritis Synovium. Journal of Immunology, 184 (7). pp. 3336-3340. ISSN 0022-1767 (doi:10.4049/jimmunol.0903566)

Hueber, A.J., Asquith, D.L., McInnes, I.B., and Miller, A.M. (2010) Embracing novel cytokines in RA – complexity grows as does opportunity! Best Practice and Research: Clinical Rheumatology, 24 (4). pp. 479-487. ISSN 1521-6942 (doi:10.1016/j.berh.2010.01.004)

McLaren, J.E., Michael, D.R., Salter, R.C., Ashlin, T.G., Calder, C.J., Miller, A.M., Liew, F.Y., and Ramji, D.P. (2010) IL-33 Reduces Macrophage Foam Cell Formation. Journal of Immunology, 185 (2). pp. 1222-1229. ISSN 0022-1767 (doi:10.4049/jimmunol.1000520)

Miller, A. M., Asquith, D. L., Hueber, A. J., Anderson, L. A., Holmes, W.M., McKenzie, A. N., Xu, D., Sattar, N., McInnes, I. B., and Liew, F. Y. (2010) Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice. Circulation Research, 107 (5). pp. 650-658. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.110.218867)

2009

Asquith, D, Miller, A.M., McInnes, I, and Liew, FY (2009) Animal models of rheumatoid arthritis. European Journal of Immunology, 39 (8). pp. 2040-2044. ISSN 0014-2980 (doi:10.1002/eji.200939578 )

Asquith, D, Miller, AM, Hueber, AJ, McKinnon, HJ, Sattar, NA, Graham, GJ, and McInnes, Iain (2009) Liver X Receptor Agonism Promotes Articular Inflammation in Murine Collagen-Induced Arthritis. Arthritis and Rheumatism, 60 (9). pp. 2655-2665. ISSN 0004-3591 (doi:10.1002/art.24717 )

Asquith, D.L., Miller, A.L., McInnes, I.B., and Liew, F.Y. (2009) Autoimmune disease: rheumatoid arthritis. Animal models of rheumatoid arthritis. European Journal of Immunology, 39 . pp. 1991-2058. ISSN 0014-2980

2008

Miller, A.M., Xu, D., Asquith, D., Denby, L., Li, Y., Sattar, N., Baker, A.H., McInnes, I.B., and Liew, F.Y. (2008) IL-33 reduces the development of atherosclerosis. Journal of Experimental Medicine, 205 (2). pp. 339-346. ISSN 0022-1007 (doi:10.1084/jem.20071868 )

2007

Miller, AM, and Pisa, P (2007) Tumor escape mechanisms in prostate cancer. Cancer Immunology Immunotherapy, 56 (1). pp. 81-87. ISSN 0340-7004

Tobiasova, Z, Pospisilova, D, Miller, AM, Minarik, I, Sochorova, K, Spisek, R, Rob, L, and Bartunkova, J (2007) In vitro assessment of dendritic cells pulsed with apoptotic tumor cells as a vaccine for ovarian cancer patients. Clinical Immunology, 122 (1). pp. 18-27.

2006

Miller, AM, Lundberg, K, Ozenci, V, Banham, AH, Hellstrom, M, Egevad, L, and Pisa, P (2006) CD4+CD25high T cells are enriched in the tumor and peripheral blood of prostate cancer patients. Journal of Immunology, 177 (10). pp. 7398-7405. ISSN 0022-1767

2005

Miller, AM, McPhaden, AR, Preston, A, Wadsworth, RM, and Wainwright, CL (2005) TNF alpha increases the inflammatory response to vascular balloon injury without accelerating neointimal formation. Atherosclerosis, 179 . pp. 51-59. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2004.10.019)

Miller, AM, McPhaden, AR, Preston, A, Wadsworth, RM, and Wainwright, CL (2005) TNFalpha increases the inflammatory response to vascular balloon injury without accelerating neointimal formation. Atherosclerosis, 179 (1). pp. 51-59. ISSN 0021-9150

Miller, AM, Ozenci, V, Kiessling, R, and Pisa, P (2005) Immune monitoring in a phase 1 trial of a PSA DNA vaccine in patients with hormone-refractory prostate cancer. Journal of Immunotherapy, 28 (4). pp. 389-395.

Ozenci, V, Miller, AM, Palmborg, A, Egevad, L, Jaremko, GA, Kalkner, KM, and Pisa, P (2005) Presence and specificity of tumor associated lymphocytes from ascites fluid in prostate cancer. Prostate, 65 (1). pp. 20-26.

2004

Kennedy, S, Preston, AA, McPhaden, AR, Miller, AM, Wainwright, CL, and Wadsworth, RM (2004) Correlation of changes in nitric oxide synthase, superoxide dismutase and nitrotyrosine with endothelial regeneration and neointimal hyperplasia in the balloon-injured rabbit subclavian artery. Coronary Artery Disease, 15 (6). pp. 337-346. (doi:10.1097/00019501-200409000-00007)

Pavlenko, M et al. (2004) A phase I trial of DNA vaccination with a plasmid expressing prostate-specific antigen in patients with hormone-refractory prostate cancer. British Journal of Cancer, 91 (4). pp. 688-694. ISSN 0007-0920

2002

Wainwright, CL, Miller, AM, Work, LM, and Del Soldato, P (2002) NCX4016 (NO-aspirin) reduces infarct size and suppresses arrhythmias following myocardial ischaemia/reperfusion in pigs. British Journal of Pharmacology, 135 (8). pp. 1882-1888. ISSN 0007-1188

2001

Kennedy, S, Miller, AM, Wadsworth, RM, McPhaden, AR, and Wainwright, CL (2001) Validation of a technique to measure leukocyte adhesion to arterial segments: effects of drug treatments. Journal of Immunological Methods, 257 (01-Feb). pp. 203-211. (doi:10.1016/S0022-1759(01)00443-4)

Miller, AM, McPhaden, AR, Wadsworth, RM, and Wainwright, CL (2001) Inhibition by leukocyte depletion of neointima formation after balloon angioplasty in a rabbit model of restenosis. Cardiovascular Research, 49 (4). pp. 838-850. ISSN 0008-6363

Wainwright, CL, Miller, AM, and Wadsworth, RM (2001) Inflammation as a key event in the development of neointima following vascular balloon injury. Clinical and Experimental Pharmacology and Physiology, 28 (11). pp. 891-895.

1998

Kennedy, S, Work, L, Ferris, P, Miller, AM, McManus, B, Wadsworth, RM, and Wainwright, CL (1998) Role of nitric oxide and free radicals in the contractile response to non-preactivated leukocytes. European Journal of Pharmacology, 345 (3). pp. 269-277. ISSN 0014-2999

This list was generated on Wed Jun 19 20:49:02 2013 BST.

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Role of interleukin-33 (IL-33) and its ST2 receptor in post-ischaemic vascular repair
    British Heart Foundation
    2012 - 2014
     
  • The effect of atherosclerosis and lipid abnormalities on rheumatoid arthritis pathology
    Tenovus-Scotland
    2010 - 2011
     
  • Interleukin-33: A Novel Cytokine in the Inflammation of Atherosclerosis and Obesity
    British Heart Foundation
    2008 - 2013