Professor Arvind Patel

Professor of Viral Vaccinology (Virology)

telephone: 01413304026
email: Arvind.Patel@glasgow.ac.uk

Centre for Virus Research, Sir Michael Stoker Building, 464 Bearsden Road, Glasgow, G61 1qh

https://orcid.org/0000-0003-4600-2047

Research interests

Virus image CVR Supporting COVID-19 Research Response

Over 170 million people worldwide are persistently infected with hepatitis C virus (HCV). In many cases, the consequences of chronic HCV infection are life-threatening, the most serious outcomes being liver cirrhosis and hepatocellular carcinoma. The efficacy of current treatment regimens has improved with the addition of new directly acting antivirals. However, there are a number of drawbacks including limitation of the therapy to patients with genotype 1 HCV infection, increased rate of adverse effects, low tolerance and high cost. Moreover, there is currently no vaccine available.

A major hurdle for the design of effective treatments and vaccines is the significant genetic variation of the virus worldwide. This is a result of the inherent high mutation rate of the virus enabling it to rapidly evolve and evade the host immune responses. In order to develop new targets for effective therapy and preventative vaccines it is necessary to gain greater understanding of the processes involved in virus infection and the effect on cellular metabolism.

The research in my group is focused on:

Molecular aspects of virus infection and replication with a specific emphasis on studying mechanisms of virus entry and morphogenesis
Virus-host interactions and viral pathogenesis
Factors involved in progression to liver disease. Here our work is particularly focused on investigating host immunity in cohorts of HCV-infected patients with respect to the B-cell and antibody responses and their links with extrahepatic disorders
Vaccine development – we are using structural and antibody-based approaches to develop novel candidate vaccines
High-throughput screens of large compound libraries to identify novel inhibitors of virus infection that would also facilitate basic research on viral life cycle at the mechanistic level.

In addition, my group is closely linked to the HCV Research Action Plan - the Glasgow HCV Network (a consortium of local clinicians and scientists whose mission is to improve the outcome for those infected with HCV), and HCV Research UK (a consortium of leading UK scientists and clinicians whose aim is to establish a nation-wide clinical database and a bio-bank of patient samples to promote research on HCV).

Publications

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Number of items: 153.

2024

Tandavanitj, R., Setthapramote, C., De Lorenzo, G. , Sanchez-Velazquez, R., Clark, J. J., Rocchi, M., McInnes, C., Kohl, A. and Patel, A. H. (2024) Virus-like particles of louping ill virus elicit potent neutralizing antibodies targeting multimers of viral envelope protein. Vaccine, (doi: 10.1016/j.vaccine.2024.03.008) (In Press)

Samolej, J., Correa Mendonca, D. , Upfold, N. , McElwee, M., Landsberger, M., Yakimovich, A., Patel, A. H. , Strang, B. L. and Mercer, J. (2024) Bisbenzimide compounds inhibit the replication of prototype and pandemic potential poxviruses. Microbiology Spectrum, (doi: 10.1128/spectrum.04072-23) (PMID:38376353) (Early Online Publication)

2023

Michael, B. D. et al. (2023) Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 14, 8487. (doi: 10.1038/s41467-023-42320-4) (PMID:38135686) (PMCID:PMC10746705)

Gonzalo Nadal, V. et al. (2023) Suspected tick-borne flavivirus meningoencephalomyelitis in dogs from the UK: six cases (2021). Journal of Small Animal Practice, (doi: 10.1111/jsap.13682) (PMID:37956993) (Early Online Publication)

Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)

Wallace, S. et al. (2023) Multiplexed biosensing of proteins and virions with disposable plasmonic assays. ACS Sensors, 8(9), pp. 3338-3348. (doi: 10.1021/acssensors.2c02238) (PMID:37610841) (PMCID:PMC10521139)

da Silva Sanches, P. R., Sanchez-Velazquez, R., Nogueira Batista, M., Moreira Carneiro, B., Bittar, C., De Lorenzo, G. , Rahal, P., Patel, A. H. and Maffud Cilli, E. (2023) Antiviral evaluation of new synthetic bioconjugates based on GA-Hecate: A new class of antivirals targeting different steps of Zika Virus replication. Molecules, 28(13), 4884. (doi: 10.3390/molecules28134884) (PMID:37446546) (PMCID:PMC10343505)

Czarnota, A., Offersgaard, A., Owsianka, A., Peña Alzua, G., Bukh, J., Gottwein, J. M., Patel, A. H. , Bieńkowska-Szewczyk, K. and Grzyb, K. (2023) The effect of glycan shift on antibodies against HCV E2 412-425 epitope elicited by chimeric sHBsAg-based virus-like particles. Microbiology Spectrum, 11(2), e02546-22. (doi: 10.1128/spectrum.02546-22) (PMID:36719195) (PMCID:PMC10100762)

Mancini, M. V. et al. (2023) Evaluation of an engineered Zika virus-like particle vaccine candidate in a mosquito-mouse transmission model. mSphere, 8(2), e00564-22. (doi: 10.1128/msphere.00564-22) (PMID:36840596) (PMCID:PMC10117074)

2022

Lista, M. J. et al. (2022) The P681H mutation in the spike glycoprotein of the alpha variant of SARS-CoV-2 escapes IFITM restriction and is necessary for type I interferon resistance. Journal of Virology, 96(23), e0125022. (doi: 10.1128/jvi.01250-22) (PMID:36350154) (PMCID:PMC9749455)

Bamford, C. G.C., Aranday-Cortes, E. , Sanchez-Velazquez, R., Mullan, C., Kohl, A. , Patel, A. H. , Wilson, S. J. and McLauchlan, J. (2022) A human and rhesus macaque interferon-stimulated gene screen shows that over-expression of ARHGEF3/XPLN inhibits replication of hepatitis C virus and other flavivirids. Viruses, 14(8), 1655. (doi: 10.3390/v14081655) (PMID:36016278) (PMCID:PMC9414520)

Willett, B. J. et al. (2022) SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(8), pp. 1161-1179. (doi: 10.1038/s41564-022-01143-7) (PMID:35798890) (PMCID:PMC9352574)

Cowton, V. M., Dunlop, J. I., Cole, S. J., Swann, R. E. and Patel, A. H. (2022) The neutralizing antibody responses of individuals that spontaneously resolve hepatitis C virus infection. Viruses, 14(7), 1391. (doi: 10.3390/v14071391) (PMID:35891372) (PMCID:PMC9318067)

Heuss, C. et al. (2022) A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo. PLoS Pathogens, 18(6), e1010472. (doi: 10.1371/journal.ppat.1010472) (PMID:35763545) (PMCID:PMC9273080)

Bryden, S. R. et al. (2022) Exploration of immunological responses underpinning severe fever with thrombocytopenia syndrome virus infection reveals IL-6 as a therapeutic target in an immunocompromised mouse model. PNAS Nexus, 1(1), pgac024. (doi: 10.1093/pnasnexus/pgac024) (PMID:35529317) (PMCID:PMC9071185)

Zhou, J. et al. (2022) Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Cell Reports, 38(6), 110344. (doi: 10.1016/j.celrep.2022.110344) (PMID:35093235) (PMCID:PMC8768428)

2021

Davis, C. et al. (2021) Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination. PLoS Pathogens, 17(12), e1010022. (doi: 10.1371/journal.ppat.1010022) (PMID:34855916) (PMCID:PMC8639073)

Sudhindar, P. D. et al. (2021) HCV activates somatic L1 retrotransposition–A potential hepatocarcinogenesis pathway. Cancers, 13(20), 5079. (PMCID:PMC8533982)

Sudhindar, P. D. et al. (2021) HCV activates somatic L1 retrotransposition—a potential hepatocarcinogenesis pathway. Cancers, 13(20), 5079. (doi: 10.3390/cancers13205079) (PMID:34680227) (PMCID:PMC8533982)

Szemiel, A. M. et al. (2021) In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2. PLoS Pathogens, 17(9), e1009929. (doi: 10.1371/journal.ppat.1009929) (PMID:34534263) (PMCID:PMC8496873)

Meuleman, T. J., Cowton, V. M., Patel, A. H. and Liskamp, R. M.J. (2021) Design and synthesis of HCV-E2 glycoprotein epitope mimics in the molecular construction of potential as synthetic vaccines. Viruses, 13(2), 326. (doi: 10.3390/v13020326) (PMID:33672697) (PMCID:PMC7924389)

Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)

Bergner, L. M. , Orton, R. J. , Broos, A. , Tello, C., Becker, D. J., Carrera, J. E., Patel, A. H. , Biek, R. and Streicker, D. G. (2021) Diversification of mammalian deltaviruses by host shifting. Proceedings of the National Academy of Sciences of the United States of America, 118(3), e201990711. (doi: 10.1073/pnas.2019907118) (PMID:33397804) (PMCID:PMC7826387)

Cowton, V. M. et al. (2021) Development of a structural epitope mimic: an idiotypic approach to HCV vaccine design. npj Vaccines, 6, 7. (doi: 10.1038/s41541-020-00269-1) (PMID:33420102) (PMCID:PMC7794244)

De Lorenzo, G. et al. (2021) Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge. Journal of Virology, 95(1), e01415-20. (doi: 10.1128/JVI.01415-20) (PMID:33028720) (PMCID:PMCID: PMC7737734)

2020

Gordon, D. E. et al. (2020) Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science, 370(6521), eabe9403. (doi: 10.1126/science.abe9403) (PMID:33060197) (PMCID:PMC7808408)

Sanchez Velazquez, R. et al. (2020) Generation of a reporter yellow fever virus for high throughput antiviral assays. Antiviral Research, 183, 104939. (doi: 10.1016/j.antiviral.2020.104939) (PMID:32980446) (PMCID:PMC7649875)

López-Camacho, C. et al. (2020) Immunogenicity and efficacy of Zika virus Envelope Domain III in DNA, protein and ChAdOx1 adenoviral-vectored vaccines. Vaccines, 8(2), 307. (doi: 10.3390/vaccines8020307) (PMID:32560145)

Meuleman, T. J., Cowton, V. M., Patel, A. H. and Liskamp, R. M.J. (2020) Improving the aqueous solubility of HCV-E2 glycoprotein epitope mimics by cyclization using polar hinges. Journal of Peptide Science, 26(1), e3222. (doi: 10.1002/psc.3222) (PMID:31984607)

2019

Ansari, M. A. et al. (2019) Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. eLife, 8, e42463. (doi: 10.7554/eLife.42463) (PMID:31478835) (PMCID:PMC6721795)

Magri, A., Mokrane, O., Lauder, K., Patel, A. H. and Castagnolo, D. (2019) Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of Hepatitis C Virus. Bioorganic and Medicinal Chemistry Letters, 29(5), pp. 724-728. (doi: 10.1016/j.bmcl.2019.01.008) (PMID:30661824)

2018

Cowton, V. M., Singer, J. B., Gifford, R. J. and Patel, A. H. (2018) Predicting the effectiveness of hepatitis C virus neutralizing antibodies by bioinformatic analysis of conserved epitope residues using public sequence data. Frontiers in Immunology, 9, 1470. (doi: 10.3389/fimmu.2018.01470) (PMID:30013555) (PMCID:PMC6036255)

López-Camacho, C. et al. (2018) Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nature Communications, 9, 2441. (doi: 10.1038/s41467-018-04859-5) (PMID:29934593) (PMCID:PMC6015009)

Krapchev, V. B., Rychłowska, M., Chmielewska, A., Zimmer, K., Patel, A. H. and Bieńkowska-Szewczyk, K. (2018) Recombinant Flag-tagged E1E2 glycoproteins from three hepatitis C virus genotypes are biologically functional and elicit cross-reactive neutralizing antibodies in mice. Virology, 519, pp. 33-41. (doi: 10.1016/j.virol.2018.03.026) (PMID:29631174) (PMCID:PMC5998380)

Meuleman, T. J., Dunlop, J. I., Owsianka, A. M., van de Langemheen, H., Patel, A. H. and Liskamp, R. M.J. (2018) Immobilization by surface conjugation of cyclic peptides for effective mimicry of the HCV-envelope E2 protein as a strategy toward synthetic vaccines. Bioconjugate Chemistry, 29(4), pp. 1091-1101. (doi: 10.1021/acs.bioconjchem.7b00755) (PMID:29382188)

Kumar, R., Singh, N., Abdin, M. Z., Patel, A. H. and Medigeshi, G. R. (2018) Dengue virus capsid interacts with DDX3X-a potential mechanism for suppression of antiviral functions in dengue infection. Frontiers in Cellular and Infection Microbiology, 7, 542. (doi: 10.3389/fcimb.2017.00542) (PMID:29387631) (PMCID:PMC5776122)

Mesalam, A. A. et al. (2018) Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1. Virology, 514, pp. 30-41. (doi: 10.1016/j.virol.2017.10.019) (PMID:29128754)

2017

Desombere, I. et al. (2017) A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo. Antiviral Research, 148, pp. 53-64. (doi: 10.1016/j.antiviral.2017.10.015) (PMID:29074219) (PMCID:PMC5785094)

Naiyer, M. M. et al. (2017) KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C. Science Immunology, 2(15), eaal5296. (doi: 10.1126/sciimmunol.aal5296) (PMID:28916719)

Naik, A. S., Owsianka, A., Palmer, B. A., Halloran, C. J., Walsh, N., Crosbie, O., Kenny-Walsh, E., Patel, A. H. and Fanning, L. J. (2017) Reverse epitope mapping of the E2 glycoprotein in antibody associated hepatitis C virus. PLoS ONE, 12(5), e0175349. (doi: 10.1371/journal.pone.0175349) (PMID:28558001) (PMCID:PMC5448734)

Magri, A. et al. (2017) 17,β-estradiol inhibits hepatitis C virus mainly by interference with the release phase of its life cycle. Liver International, 37(5), pp. 669-677. (doi: 10.1111/liv.13303) (PMID:27885811) (PMCID:PMC5448036)

Vasiliauskaite, I. et al. (2017) Conformational flexibility in the immunoglobulin-like domain of the Hepatitis C Virus Glycoprotein E2. mBio, 8(3), e00382-17. (doi: 10.1128/mBio.00382-17) (PMID:28512091) (PMCID:PMC5433095)

Heerman van Voss, M. R. et al. (2017) Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer. OncoTargets and Therapy, 10, pp. 3501-3513. (doi: 10.2147/OTT.S140639) (PMID:28761359) (PMCID:PMC5522823)

2016

Donald, C. L. et al. (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Neglected Tropical Diseases, 10(10), e0005048. (doi: 10.1371/journal.pntd.0005048) (PMID:27706161) (PMCID:PMC5051680)

Cowton, V. M., Angus, A. G.N., Cole, S. J., Markopoulou, C. K., Owsianka, A., Dunlop, J. I., Gardner, D., Krey, T. and Patel, A. H. (2016) Role of conserved E2 residue W420 in receptor binding and hepatitis C virus infection. Journal of Virology, 90(16), pp. 7456-7468. (doi: 10.1128/JVI.00685-16) (PMID:27279607) (PMCID:PMC4984626)

Swann, R.E. , Mandalou, P., Robinson, M.W., Ow, M.M., Foung, S.K.H., McLauchlan, J. , Patel, A.H. and Cramp, M.E. (2016) Anti-envelope antibody responses in individuals at high risk of hepatitis C virus who resist infection. Journal of Viral Hepatitis, 23(11), pp. 873-880. (doi: 10.1111/jvh.12568) (PMID:27405885) (PMCID:PMC5244678)

Magri, A., Ozerov, A. A., Tunitskaya, V. L., Valuev-Elliston, V. T., Wahid, A., Pirisi, M., Simmonds, P., Ivanov, A. V., Novikov, M. S. and Patel, A. H. (2016) Exploration of acetanilide derivatives of 1-(ω-phenoxyalkyl)uracils as novel inhibitors of Hepatitis C Virus replication. Scientific Reports, 6, 29487. (doi: 10.1038/srep29487) (PMID:27406141) (PMCID:PMC4942610)

Swann, R. E. , Cowton, V. M., Robinson, M. W., Cole, S. J., Barclay, S. T., Mills, P. R., Thomson, E. C. , McLauchlan, J. and Patel, A. (2016) Broad anti-hepatitis C virus (HCV) antibody responses are associated with improved clinical disease parameters in chronic HCV infection. Journal of Virology, 90(9), pp. 4530-4543. (doi: 10.1128/JVI.02669-15) (PMID:26912610) (PMCID:PMC4836347)

Robinson, M. W., Hughes, J. , Wilkie, G. S., Swann, R. , Barclay, S. T., Mills, P. R., Patel, A. H. , Thomson, E. C. and McLauchlan, J. (2016) Tracking TCRß sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region. Frontiers in Immunology, 7, 131. (doi: 10.3389/fimmu.2016.00131) (PMID:27092143) (PMCID:PMC4820669)

Desombere, I. et al. (2016) Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge. Hepatology, 63(4), pp. 1120-1134. (doi: 10.1002/hep.28428) (PMID:26710081)

Sandomenico, A. et al. (2016) Generation and characterization of monoclonal antibodies against a cyclic variant of Hepatitis C Virus E2 epitope 412-422. Journal of Virology, 90(7), pp. 3745-3759. (doi: 10.1128/JVI.02397-15) (PMID:26819303) (PMCID:PMC4794675)

Fauvelle, C. et al. (2016) Apolipoprotein E mediates evasion from hepatitis C virus−neutralizing antibodies. Gastroenterology, 150(1), pp. 206-217. (doi: 10.1053/j.gastro.2015.09.014) (PMID:26404951)

2015

Magri, A., Reilly, R., Scalacci, N., Radi, M., Hunter, M., Ripoll, M., Patel, A. and Castagnolo, D. (2015) Rethinking the old antiviral drug moroxydine: discovery of novel analogues as anti-hepatitis C virus (HCV) agents. Bioorganic and Medicinal Chemistry Letters, 25(22), pp. 5372-5376. (doi: 10.1016/j.bmcl.2015.09.029) (PMID:26428870)

Robinson, M. W. et al. (2015) Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection. Liver International, 35(10), pp. 2256-2264. (doi: 10.1111/liv.12830) (PMID:25800823) (PMCID:PMC4949513)

Brennan, B. et al. (2015) In memoriam – Richard M. Elliott (1954–2015). Journal of General Virology, 96(8), pp. 1975-1978. (doi: 10.1099/jgv.0.000241) (PMID:26315040)

Dunlop, J., Owsianka, A., Cowton, V. and Patel, A. (2015) Current and future prophylactic vaccines for hepatitis C virus. Vaccine: Development and Therapy, 2015(5), pp. 31-44. (doi: 10.2147/VDT.S48437)

Robinson, M.W., Swann, R. , Sigruener, A., Barclay, S.T., Mills, P.R., McLauchlan, J. and Patel, A. H. (2015) Elevated interferon-stimulated gene transcription in peripheral blood mononuclear cells occurs in patients infected with genotype 1 but not genotype 3 hepatitis C virus. Journal of Viral Hepatitis, 22(4), pp. 384-390. (doi: 10.1111/jvh.12310) (PMID:25200131) (PMCID:PMC4409080)

Padickakudi, J.O., Patel, A. , Baker, E.C. and Brock, R. (2015) Fighting Ebola in Sierra Leone: the experience of frontline NHS workers. Bulletin of the Royal College of Surgeons of England, 97(3), pp. 131-133. (doi: 10.1308/147363515x14134529301507) (PMCID:PMC5074214)

2014

Zhou, X., Sun, P., Lucendo-Villarin, B., Angus, A. G.N., Szkolnicka, D., Cameron, K., Farnworth, S. L., Patel, A. H. and Hay, D. C. (2014) Modulating innate immunity improves Hepatitis C virus infection and replication in stem cell-derived hepatocytes. Stem Cell Reports, 3(1), pp. 204-214. (doi: 10.1016/j.stemcr.2014.04.018) (PMID:25068132) (PMCID:PMC4110790)

Keck, Z.-y., Angus, A. G.N., Wang, W., Lau, P., Wang, Y., Gatherer, D., Patel, A. H. and Foung, S. K.H. (2014) Non-random escape pathways from a broadly neutralizing human monoclonal antibody map to a highly conserved region on the hepatitis c virus E2 glycoprotein encompassing amino acids 412–423. PLoS Pathogens, 10(8), e1004297. (doi: 10.1371/journal.ppat.1004297) (PMID:25122476) (PMCID:PMC4133389)

Xiao, F. et al. (2014) Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents. PLoS Pathogens, 10(5), e1004128. (doi: 10.1371/journal.ppat.1004128) (PMID:24830295) (PMCID:PMC4022730)

2013

Robinson, M. W., McGuinness, D., Swann, R. , Barclay, S., Mills, P. R., Patel, A. H. , McLauchlan, J. and Shiels, P. G. (2013) Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease. Aging Cell, 12(6), pp. 1141-1143. (doi: 10.1111/acel.12125) (PMID:23931242)

Sun, P., Zhou, X., Farnworth, S.L., Patel, A.H. and Hay, D.C. (2013) Modeling human liver biology using stem cell-derived hepatocytes. International Journal of Molecular Sciences, 14(11), pp. 22011-22021. (doi: 10.3390/ijms141122011) (PMID:24201130) (PMCID:PMC3856048)

Pantua, H. et al. (2013) Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies. Journal of Molecular Biology, 425(11), pp. 1899-1914. (doi: 10.1016/j.jmb.2013.02.025) (PMID:23458406)

Keck, Z., Wang, W., Wang, Y., Lau, P., Carlsen, T.H.R., Prentoe, J., Xia, J., Patel, A.H. , Bukh, J. and Foung, S.K.H. (2013) Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein. Journal of Virology, 87(1), pp. 37-51. (doi: 10.1128/JVI.01941-12) (PMID:23097455) (PMCID:PMC3536422)

Bol, G.M., Raman, V., van der Groep, P., Vermeulen, J.F., Patel, A.H. , van der Wall, E. and van Diest, P.J. (2013) Expression of the RNA helicase DDX3 and the hypoxia response in breast cancer. PLoS ONE, 8(5), e63548. (doi: 10.1371/journal.pone.0063548) (PMID:23696831) (PMCID:PMC3656050)

2012

Potter, J. A., Owsianka, a. A. M., Jeffery, N., Matthews, D. J., Keck, Z.-Y., Lau, P., Foung, S. K. H., Taylor, G. L. and Patel, A. H. (2012) Toward a hepatitis C virus vaccine: the structural basis of hepatitis C virus neutralization by AP33, a broadly neutralizing antibody. Journal of Virology, 86(23), pp. 12923-12932. (doi: 10.1128/JVI.02052-12) (PMID:22993159) (PMCID:PMC349765)

Lacek, K. et al. (2012) Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice. Journal of Hepatology, 57(1), pp. 17-23. (doi: 10.1016/j.jhep.2012.02.018) (PMID:22414763)

Keck, Z. et al. (2012) Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate. PLoS Pathogens, 8(4), e1002653. (doi: 10.1371/journal.ppat.1002653) (PMID:22511875) (PMCID:PMC3325216)

Angus, A.G.N., Loquet, A., Stack, S.J., Dalrymple, D., Gatherer, D., Penin, F. and Patel, A.H. (2012) Conserved glycine 33 residue in flexible domain I of hepatitis C virus core protein is critical for virus infectivity. Journal of Virology, 86(2), pp. 679-690. (doi: 10.1128/jvi.05452-11) (PMID:22072760) (PMCID:PMC3255827)

2011

Rychlowska, M., Owsianka, A.M., Foung, S.K.H., Dubuisson, J., Bienkowska-Szewczyk, K. and Patel, A.H. (2011) Comprehensive linker-scanning mutagenesis of the hepatitis C virus E1 and E2 envelope glycoproteins reveals new structure-function relationships. Journal of General Virology, 92(10), pp. 2249-2261. (doi: 10.1099/vir.0.034314-0) (PMID:21697343) (PMCID:PMC3347801)

Vieyres, G., Dubuisson, J. and Patel, A.H. (2011) Characterization of antibody-mediated neutralization directed against the hypervariable region 1 of hepatitis C virus E2 glycoprotein. Journal of General Virology, 92(3), pp. 494-506. (doi: 10.1099/vir.0.028092-0) (PMID:21084495) (PMCID:PMC3081231)

Angus, A. G. N. and Patel, A. H. (2011) Immunotherapeutic potential of neutralizing antibodies targeting conserved regions of the HCV envelope glycoprotein E2. Future Microbiology, 6(3), pp. 279-294. (doi: 10.2217/fmb.11.9) (PMID:21449840)

Botlagunta, M., Krishnamachary, B., Vesuna, F., Winnard, P.T., Bol, G.M., Patel, A.H. and Ramanathan, V. (2011) Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells. PLoS ONE, 6(3), e17563. (doi: 10.1371/journal.pone.0017563) (PMID:21448281) (PMCID:PMC3063174)

Lorenzo, C. D., Angus, A. G.N. and Patel, A. H. (2011) Hepatitis C virus evasion mechanisms from neutralizing antibodies. Viruses, 3(11), pp. 2280-2300. (doi: 10.3390/v3112280) (PMID:22163345) (PMCID:PMC3230852)

Lupberger, J. et al. (2011) EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nature Medicine, 17(5), pp. 589-595. (doi: 10.1038/nm.2341) (PMID:21516087) (PMCID:PMC3938446)

2010

Brown, K.S., Keogh, M.J., Owsianka, A.M., Adair, R., Patel, A.H. , Arnold, J.N., Ball, J.K., Sim, R.B., Tarr, A.W. and Hickling, T.P. (2010) Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry. Protein and Cell, 1(7), pp. 664-674. (doi: 10.1007/s13238-010-0088-9) (PMID:21203938)

Dhillon, S. et al. (2010) Mutations within a conserved region of the hepatitis C virus E2 glycoprotein that influence virus-receptor interactions and sensitivity to neutralizing antibodies. Journal of Virology, 84(11), pp. 5494-5507. (doi: 10.1128/JVI.02153-09) (PMID:20237087) (PMCID:PMC2876616)

Angus, A.G.N. et al. (2010) Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein. Journal of General Virology, 91(1), pp. 122-132. (doi: 10.1099/vir.0.015909-0) (PMID:19793905) (PMCID:PMC2885062)

Al Niaimi, F., Patel, A. , Blessing, K., Fox, R. and Burden, A. D. (2010) Cutaneous actinomycosis presenting as chronic mastitis. Clinical and Experimental Dermatology, 35(2), pp. 149-151. (doi: 10.1111/j.1365-2230.2009.03159.x)

Fafi-Kremer, S. et al. (2010) Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation. Journal of Experimental Medicine, 207(9), pp. 2019-2031. (doi: 10.1084/jem.20090766) (PMID:20713596) (PMCID:PMC2931157)

Reszka, N., Krol, E., Patel, A.H. and Szewczyk, B. (2010) Effect of tunicamycin on the biogenesis of hepatitis C virus glycoproteins. Acta Biochimica Polonica, 57(4), pp. 541-546. (PMID:21140004)

Vieyres, G., Thomas, X., Descamps, V., Duverlie, G., Patel, A. H. and Dubuisson, J. (2010) Characterization of the Envelope Glycoproteins Associated with Infectious Hepatitis C Virus. Journal of Virology, 84(19), pp. 10159-10168. (doi: 10.1128/JVI.01180-10) (PMID:20668082) (PMCID:PMC3063174)

2009

Mancini, N., Diotti, R.A., Perotti, M., Sautto, G., Clementi, N., Nitti, G., Patel, A.H., Ball, J.K., Clementi, M. and Burioni, R. (2009) Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes. PLoS ONE, 4(12), e8254. (doi: 10.1371/journal.pone.0008254) (PMID:20011511) (PMCID:PMC2785886)

Brohm, C., Steinmann, E., Friesland, M., Lorenz, I. C., Patel, A. , Penin, F., Bartenschlager, R. and Pietschmann, T. (2009) Characterization of determinants important for hepatitis C virus p7 function in morphogenesis by using trans-complementation. Journal of Virology, 83(22), pp. 11682-11693. (doi: 10.1128/JVI.00691-09) (PMID:19726506) (PMCID:PMC2772676)

Hughes, M., Gretton, S., Shelton, H., Brown, D.D., McCormick, C.J., Angus, A.G.N., Patel, A.H., Griffin, S. and Harris, M. (2009) A conserved proline between domains II and III of hepatitis C virus NS5A influences both RNA replication and virus assembly. Journal of Virology, 83(20), pp. 10788-10796. (doi: 10.1128/JVI.02406-08) (PMID:19656877) (PMCID:PMC2753128)

Iro, M., Witteveldt, J., Angus, A.G.N., Woerz, I., Kaul, A., Bartenschlager, R. and Patel, A.H. (2009) A reporter cell line for rapid and sensitive evaluation of hepatitis C virus infectivity and replication. Antiviral Research, 83(2), pp. 148-155. (doi: 10.1016/j.antiviral.2009.04.007) (PMID:19397930)

Keck, Z.Y. et al. (2009) Mutations in hepatitis c virus e2 located outside the cd81 binding sites lead to escape from broadly neutralizing antibodies but compromise virus infectivity. Journal of Virology, 83(12), pp. 6149-6160. (doi: 10.1128/JVI.00248-09) (PMID:19321602) (PMCID:PMC2687388)

Adair, R., Patel, A.H., Corless, L., Griffin, S., Rowlands, D.J. and McCormick, C.J. (2009) Expression of hepatitis C virus (HCV) structural proteins in trans facilitates encapsidation and transmission of HCV subgenomic RNA. Journal of General Virology, 90(4), pp. 833-842. (doi: 10.1099/vir.2008.006049-0) (PMID:19223490)

Vieyres, G., Angus, A.G.N., Haberstroh, A., Baumert, T.F., Dubuisson, J. and Patel, A.H. (2009) Rapid synchronization of hepatitis C virus infection by magnetic adsorption. Journal of Virological Methods, 157(1), pp. 69-79. (doi: 10.1016/j.jviromet.2008.11.015) (PMID:19100780)

Jones, D. M., Patel, A. H., Targett-Adams, P. and McLauchlan, J. (2009) The hepatitis c virus ns4b protein can trans-complement viral rna replication and modulates production of infectious virus. Journal of Virology, 83(5), pp. 2163-2177. (doi: 10.1128/JVI.01885-08) (PMID:19073716) (PMCID:PMC2643717)

Witteveldt, J. et al. (2009) CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells. Journal of General Virology, 90(1), pp. 48-58. (doi: 10.1099/vir.0.006700-0) (PMID:19088272) (PMCID:PMC2885024)

2008

Gal-Tanamy, M., Keck, Z.-Y., Yi, M., McKeating, J. A., Patel, A. H., Foung, S. K. H. and Lemon, S. M. (2008) In vitro selection of a neutralization-resistant hepatitis C virus escape mutant. Proceedings of the National Academy of Sciences of the United States of America, 105(49), pp. 19450-19455. (doi: 10.1073/pnas.0809879105) (PMID:19052239) (PMCID:PMC2614781)

Griffin, S., StGelais, C., Owsianka, A.M., Patel, A.H., Rowlands, D. and Harris, M. (2008) Genotype-dependent sensitivity of hepatitis c virus to inhibitors of the p7 ion channel. Hepatology, 48(6), pp. 1779-1790. (doi: 10.1002/hep.22555) (PMID:18828153)

Haberstroh, A. et al. (2008) Neutralizing host responses in hepatitis c virus infection target viral entry at postbinding steps and membrane fusion. Gastroenterology, 135(5), 1719-1728.e1. (doi: 10.1053/j.gastro.2008.07.018) (PMID:18718838)

Lee, C.S., Dais, A.P., Jedrychowski, M., Patel, A.H., Hsu, J.L. and Reed, R. (2008) Human DDX3 functions in translation and interacts with the translation initiation factor eIF3. Nucleic Acids Research, 36(14), pp. 4708-4718. (doi: 10.1093/nar/gkn454) (PMID:18628297) (PMCID:PMC2504307)

Botlagunta, M. et al. (2008) Oncogenic role of DDX3 in breast cancer biogenesis. Oncogene, 27, pp. 3912-3922. (doi: 10.1038/onc.2008.33) (PMID:18264132)

Keck, Z.-Y., Li, T.-K., Xia, J., Gal-Tanamy, M., Olson, O., Li, S.H., Patel, A.H. , Ball, J.K., Lemon, S.M. and Foung, S.K.H. (2008) Definition of a conserved immunodominant domain on hepatitis C virus E2 glycoprotein by neutralizing human monoclonal antibodies. Journal of Virology, 82(12), pp. 6061-6066. (doi: 10.1128/jvi.02475-07) (PMID:18400849) (PMCID:PMC2395155)

Keck, Z.Y., Olson, O., Gal-Tanamy, M., Xia, J., Patel, A.H. , Dreux, M., Cosset, F.L., Lemon, S.M. and Foung, S.K.H. (2008) A point mutation leading to hepatitis C virus escape from neutralization by a monoclonal antibody to a conserved conformational epitope. Journal of Virology, 82(12), pp. 6067-6072. (doi: 10.1128/JVI.00252-08) (PMID:18385242) (PMCID:PMC2395135)

Owsianka, A.M., Tarr, A.W., Keck, Z.Y., Li, T.K., Witteveldt, J., Adair, R., Foung, S.K.H., Ball, J.K. and Patel, A.H. (2008) Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein. Journal of General Virology, 89(3), pp. 653-659. (doi: 10.1099/vir.0.83386-0) (PMID:18272755) (PMCID:PMC2885755)

Perotti, M., Mancini, N., Diotti, R.A., Tarr, A.W., Ball, J.K., Owsianka, A., Adair, R., Patel, A.H. , Clementi, M. and Burioni, R. (2008) Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein. Journal of Virology, 82(2), pp. 1047-1052. (doi: 10.1128/JVI.01986-07) (PMID:17989176) (PMCID:PMC2224572)

Keck, Z.Y., Li, T.K., Xia, J., Gal-Tanamy, M., Olson, O., Li, S.H., Patel, A.H. , Ball, J.K., Lemon, S.M. and Foung, S.K.H. (2008) Definition of a conserved immunodominant domain on HCV E2 glycoprotein by neutralizing human monoclonal antibodies. Journal of Virology, 82(12), pp. 6061-6066. (doi: 10.1128/JVI.02475-07)

Keck, Z.Y., Machida, K., Lai, M.M.C., Ball, J.K., Patel, A.H. and Foung, S.K.H. (2008) Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies. Current Topics in Microbiology and Immunology, 317, pp. 1-38. (doi: 10.1007/978-3-540-72146-8_1) (PMID:17990788)

2007

Tarr, A.W., Owsianka, A.M., Jayaraj, D., Brown, R.J.P., Hickling, T.P., Irving, W.L., Patel, A.H. and Ball, J.K. (2007) Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33. Journal of General Virology, 88(11), pp. 2991-3001. (doi: 10.1099/vir.0.83065-0) (PMID:17947521)

Tani, H. et al. (2007) Replication-competent recombinant vesicular stomatitis virus encoding hepatitis C virus envelope proteins. Journal of Virology, 81(16), pp. 8601-8612. (doi: 10.1128/jvi.00608-07) (PMID:17553880) (PMCID:PMC1951354)

Witteveldt, J., Vieyres, G. and Patel, A.H. (2007) HCV requires a tight junction-associated protein for cell entry. Future Virology, 2(4), pp. 335-338. (doi: 10.2217/17460794.2.4.335)

Pestka, J.M. et al. (2007) Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C. Proceedings of the National Academy of Sciences of the United States of America, 104(14), pp. 6025-6030. (doi: 10.1073/pnas.0607026104) (PMID:17392433) (PMCID:PMC1851610)

Keck, Z.Y., Xai, J., Cai, Z., Lislevand, T.K., Owsianka, A.M., Patel, A.H. , Luo, G. and Foung, S.K.H. (2007) Immunogenic and functional organization of hepatitis C virus (HCV) glycoprotein E2 on infectious HCV virions. Journal of Virology, 81(2), pp. 1043-1047. (doi: 10.1128/JVI.01710-06) (PMID:17079294) (PMCID:PMC1797433)

Steinmann, E., Penin, F., Kallis, S., Patel, A.H. , Bartenschlager, R. and Pietschmann, T. (2007) Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions. PLoS Pathogens, 3(7), e103. (doi: 10.1371/journal.ppat.0030103) (PMID:17658949) (PMCID:PMC1924870)

Tarr, A.W., Owsianka, A.M., Szwejk, A., Ball, J.K. and Patel, A.H. (2007) Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins. In: Glycovirology Protocols. Series: Methods in Molecular Biology, 379. Humana Press, pp. 177-197. ISBN 9781588295903 (doi: 10.1007/978-1-59745-393-6_13)

Willberg, C.B., Ward, S.M., Clayton, R.F., Naoumov, N.V., McCormick, C., Proto, S., Harris, M., Patel, A.H. and Klenerman, P. (2007) Protection of hepatocytes from cytotoxic T cell mediated killing by interferon-alpha. PLoS ONE, 2(8), e791. (doi: 10.1371/journal.pone.0000791) (PMID:17726521) (PMCID:PMC1949144)

2006

Barth, H., Schnober, E.K., Zhang, F., Linhardt, R.J., Depla, E., Boson, B., Cosset, F.-L., Patel, A.H. , Blum, H.E. and Baumert, T.F. (2006) Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction. Journal of Virology, 80(21), pp. 10579-10590. (doi: 10.1128/jvi.00941-06) (PMID:16928753) (PMCID:PMC1641783)

Owsianka, A.M., Timms, J.M., Tarr, A.W., Brown, R.J.P., Hickling, T.P., Szwejk, A., Bienkowska-Szewczyk, K., Thomson, B.J., Patel, A.H. and Ball, J.K. (2006) Identification of conserved residues in the E2 envelope glycoprotein of the hepatitis C virus that are critical for CD81 binding. Journal of Virology, 80(17), pp. 8695-8704. (doi: 10.1128/jvi.00271-06) (PMID:16912317) (PMCID:PMC1563869)

Haberstroh, A., Barth, H., Schnober, E.K., Pestka, J.M., Diepolder, H.M., Gerlach, J.T., Patel, A.H. , Blum, H.E., Cosset, F. and Baumert, T.F. (2006) 54 Cellular binding and entry of hepatitis C virus pseudotypes and virus-like particles requires a different set of cellular co-receptors. Journal of Hepatology, 44(S2), S25. (doi: 10.1016/s0168-8278(06)80055-3)

Rouille, Y. et al. (2006) Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus. Journal of Virology, 80(6), pp. 2832-2841. (doi: 10.1128/JVI.80.6.2832-2841.2006) (PMID:16501092) (PMCID:PMC1395453)

Tarr, A.W., Owsianka, A.M., Timms, J.M., McClure, C.P., Brown, R.J.B., Hickling, T.P., Pietschmann, T., Bartenschlager, R., Patel, A.H. and Ball, J.K. (2006) Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33. Hepatology, 43(3), pp. 592-601. (doi: 10.1002/hep.21088) (PMID:16496330)

Matsuo, E. et al. (2006) Characterization of HCV-like particles produced in a human hepatoma cell line by a recombinant baculovirus. Biochemical and Biophysical Research Communications, 340(1), pp. 200-208. (doi: 10.1016/j.bbrc.2005.12.001) (PMID:16360642)

2005

Owsianka, A., Tarr, A.W., Juttla, V.S., Lavillette, D., Bartosch, B., Cosset, F.-L., Ball, J.K. and Patel, A.H. (2005) Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein. Journal of Virology, 79(17), pp. 11095-11104. (doi: 10.1128/jvi.79.17.11095-11104.2005)

Yamada, E., Montoya, M., Schuettler, C.G., Hickling, T.P., Tarr, A.W., Vitelli, A., Dubisson, J., Patel, A.H. , Ball, J.K. and Borrow, P. (2005) Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets. Journal of General Virology, 86(9), pp. 2507-2512. (doi: 10.1099/vir.0.81169-0)

Isherwood, B.J. and Patel, A.H. (2005) Analysis of the processing and transmembrane topology of the E2p7 protein of hepatitis C virus. Journal of General Virology, 86(3), pp. 667-676. (doi: 10.1099/vir.0.80737-0)

Lavillette, D., Tarr, A.W., Voisset, C., Donot, P., Bartosch, B., Bain, C., Patel, A.H. , Dubuisson, J., Ball, J.K. and Cosset, F. (2005) Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus. Hepatology, 41(2), pp. 265-274. (doi: 10.1002/hep.20542)

Clayton, R.F., Edward, M., Kandyba, E.E., Klenerman, P., Patel, A.H. , Rinaldi, A. and Willberg, C. (2005) Liver cell lines for the study of hepatocyte functions and immunological response. Liver International, 25(2), pp. 389-402. (doi: 10.1111/j.1478-3231.2005.01017.x)

2004

Yurkova, M.S., Patel, A.H. and Fedorov, A.N. (2004) Characterisation of bacterially expressed structural protein E2 of hepatitis C virus. Protein Expression and Purification, 37(1), pp. 119-125. (doi: 10.1016/j.pep.2004.05.016)

Steinmann, D. et al. (2004) Inhibition of hepatitis C virus-like particle binding to target cells by antiviral antibodies in acute and chronic hepatitis C. Journal of Virology, 78(17), pp. 9030-9040. (doi: 10.1128/jvi.78.17.9030-9040.2004)

2003

White, C.A., Stow, N.D., Patel, A.H. , Hughes, M. and Preston, V.G. (2003) Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28. Journal of Virology, 77(11), pp. 6351-6358. (doi: 10.1128/JVI.77.11.6351-6358.2003)

Shaw, M.L., McLauchlan, J. , Mills, P.R., Patel, A.H. and McCruden, E.A.B. (2003) Characterisation of the differences between hepatitis C virus genotype 3 and 1 glycoproteins. Journal of Medical Virology, 70(3), pp. 361-372. (doi: 10.1002/jmv.10404)

Sokolowski, M., Scott, J.E., Heaney, R.P., Patel, A.H. and Clements, J.B. (2003) Identification of herpes simplex virus RNAs that interact specifically with regulatory protein ICP27 in vivo. Journal of Biological Chemistry, 278, pp. 33540-33549. (doi: 10.1074/jbc.M302063200)

2002

Triyatni, M., Saunier, B., Maruvada, P., Davison, A.R., Ulianich, L., Heller, T., Patel, A.H. , Kohn, L.D. and Liang, T.J. (2002) Interaction of hepatitis C virus-like particles and cells: a model system for studying viral binding and entry. Journal of Virology, 76(18), pp. 9335-9344. (doi: 10.1128/JVI.76.18.9335-9344.2002)

Clayton, R.F., Owsianka, A., Aitken, J., Graham, S., Bhella, D. and Patel, A.H. (2002) Analysis of antigenicity and topology of E2 glycoprotein present on recombinant hepatitis C virus-like particles. Journal of Virology, 76(18), p. 9562. (doi: 10.1128/jvi.76.18.9562.2002)

Tuplin, A., Wood, J., Evans, D. J., Patel, A. and Simmonds, P. (2002) Thermodynamic and phylogenetic prediction of RNA secondary structures in the coding region of hepatitis C virus. RNA, 8, pp. 824-841. (doi: 10.1017/S1355838202024068)

2001

Owsianka, A., Clayton, R.F., Loomis-Price, L.D., McKeating, J.A. and Patel, A.H. (2001) Functional analysis of hepatitis C virus E2 glycoproteins and virus-like particles reveals structural dissimilarities between different forms of E2. Journal of General Virology, 82(8), pp. 1877-1883.

Clayton, R.F., Owsianka, A. and Patel, A.H. (2001) Evidence for structural differences in the S domain of L in comparison with S protein of hepatitis B virus. Journal of General Virology, 82(7), pp. 1533-1541.

Woods, J., Frederickson, R.M., Fields, S. and Patel, A.H. (2001) Hepatitis C virus 3'X region interacts with human ribosomal proteins. Journal of Virology, 75(3), pp. 1348-1358. (doi: 10.1128/jvi.75.3.1348-1358.2001)

Patel, J., Patel, A.H. and McLauchlan, J. (2001) The transmembrane domain of the hepatitis C virus E2 glycoprotein is required for correct folding of the E1 glycoprotein and native complex formation. Virology, 279(1), pp. 58-68. (doi: 10.1006/viro.2000.0693)

2000

Abbotts, A.P., Preston, V.G., Hughes, M., Patel, A.H. and Stow, N.D. (2000) Interaction of the herpes simplex virus type 1 packaging protein UL15 with full-length and deleted forms of the UL28 protein. Journal of General Virology, 81(12), pp. 2999-3009.

Patel, A.H. , Wood, J., Penin, F., Dubuisson, J. and McKeating, J.A. (2000) Construction and characterization of chimeric hepatitis C virus E2 glycoproteins: analysis of regions critical for glycoprotein aggregation and CD81 binding. Journal of General Virology, 81(12), pp. 2873-2883.

1999

Patel, J., Patel, A.H. and McLauchlan, J. (1999) Covalent interactions are not required to permit or stabilize the non-covalent association of hepatitis C virus glycoproteins E1 and E2. Journal of General Virology, 80(7), pp. 1681-1690.

Owsianka, A.M. and Patel, A.H. (1999) Hepatitis C virus core protein interacts with a human DEAD box protein DDX3. Virology, 257(2), pp. 330-340. (doi: 10.1006/viro.1999.9659)

1997

Phelan, A., Dunlop, J., Patel, A.H. , Stow, N.D. and Clements, J.B. (1997) Nuclear sites of herpes simplex virus type 1 DNA replication and transcription colocalize at early times postinfection and are largely distinct from RNA processing factors. Journal of Virology, 71(2), pp. 1124-1132.

1996

Marsden, H.S., Cross, A.M., Francis, G.J., Patel, A.H. , MacEachran, K., Murphy, M., McVey, G., Haydon, D. , Abbotts, A. and Stow, N.D. (1996) The herpes simplex virus type 1 UL8 protein influences the intracellular localization of the UL52 but not the ICP8 or POL replication proteins in virus-infected cells. Journal of General Virology, 77(9), pp. 2241-2249. (doi: 10.1099/0022-1317-77-9-2241)

Patel, A.H. , Rixon, F.J., Cunningham, C. and Davison, A.J. (1996) Isolation and characterization of herpes simplex virus type 1 mutants defective in the UL6 gene. Virology, 217(1), pp. 111-123. (doi: 10.1006/viro.1996.0098)

Patel, A.H. , Subak-Sharpe, J.H., Stow, N.D., Marsden, H.S., Maclean, J.B. and Dargan, D.J. (1996) Suppression of amber nonsense mutations of herpes simplex virus type 1 in a tissue culture system. Journal of General Virology, 77(2), pp. 199-209. (doi: 10.1099/0022-1317-77-2-199)

1995

Dargan, D.J., Patel, A.H. and Subak-Sharpe, J.H. (1995) PREPs: herpes simplex virus type 1-specific particles produced by infected cells when viral DNA replication is blocked. Journal of Virology, 69(8), pp. 4924-4932.

Zavizion, B., Bramley, A.J., Politis, I., Gilmore, J., Turner, J.D., Patel, A.H. and Foster, T.J. (1995) Effects of Staphylococcus aureus toxins on the growth of bovine mammary epithelial cells (MAC-T) in culture. Journal of Dairy Science, 78(2), pp. 277-284. (doi: 10.3168/jds.S0022-0302(95)76635-8)

Patel, A.H. and MacLean, J.B. (1995) The product of the UL6 gene of herpes simplex virus type 1 is associated with virus capsids. Virology, 206(1), pp. 465-478. (doi: 10.1016/s0042-6822(95)80062-x)

1992

Gordon, S.C., Patel, A.H. , Kulesza, G.W., Barnes, R.E. and Silverman, A.L. (1992) Lack of evidence for the heterosexual transmission of hepatitis C. American Journal of Gastroenterology, 87(12), pp. 1849-1851.

Patel, A.H. , Subak-Sharpe, J.H. and Stow, N.D. (1992) The N-terminal 22 amino acids encoded by the gene specifying the major secreted protein of vaccinia virus, strain Lister, can function as a signal sequence to direct the export of a foreign protein. Virus Research, 26(3), pp. 197-212. (doi: 10.1016/0168-1702(92)90013-y)

Patel, A.H. and Elliott, R.M. (1992) Characterization of Bunyamwera virus defective interfering particles. Journal of General Virology, 73(2), pp. 389-396. (doi: 10.1099/0022-1317-73-2-389)

1990

Patel, A.H. , Gaffney, D.F., Subak-Sharpe, J.H. and Stow, N.D. (1990) DNA sequence of the gene encoding a major secreted protein of vaccinia virus, strain Lister. Journal of General Virology, 71(9), pp. 2013-2021. (doi: 10.1099/0022-1317-71-9-2013)

1989

Bramley, A.J., Patel, A.H. , O'Reilly, M., Foster, R. and Foster, T.J. (1989) Roles of alpha-toxin and beta-toxin in virulence of Staphylococcus aureus for the mouse mammary gland. Infection and Immunity, 57(8), pp. 2489-2494.

Patel, A.H. , Foster, T.J. and Pattee, P.A. (1989) Physical and genetic mapping of the protein A gene in the chromosome of Staphylococcus aureus 8325-4. Journal of General Microbiology, 135(7), pp. 1799-807. (doi: 10.1099/00221287-135-7-1799)

1988

Foster, T.J., O'Reilly, M., Patel, A.H. and Bramley, A.J. (1988) Genetic studies of Staphylococcus aureus virulence factors. Antonie van Leeuwenhoek, 54(5), pp. 475-482. (doi: 10.1007/bf00461866)

1987

Patel, A.H. , Nowlan, P., Weavers, E.D. and Foster, T. (1987) Virulence of protein A-deficient and alpha-toxin-deficient mutants of Staphylococcus aureus isolated by allele replacement. Infection and Immunity, 55(12), pp. 3103-3110.

This list was generated on Mon Apr 15 14:01:49 2024 BST.

Jump to: Articles | Book Sections

Number of items: 153.

Articles

Sudhindar, P. D. et al. (2021) HCV activates somatic L1 retrotransposition–A potential hepatocarcinogenesis pathway. Cancers, 13(20), 5079. (PMCID:PMC8533982)

Ansari, M. A. et al. (2019) Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. eLife, 8, e42463. (doi: 10.7554/eLife.42463) (PMID:31478835) (PMCID:PMC6721795)

Brennan, B. et al. (2015) In memoriam – Richard M. Elliott (1954–2015). Journal of General Virology, 96(8), pp. 1975-1978. (doi: 10.1099/jgv.0.000241) (PMID:26315040)

Reszka, N., Krol, E., Patel, A.H. and Szewczyk, B. (2010) Effect of tunicamycin on the biogenesis of hepatitis C virus glycoproteins. Acta Biochimica Polonica, 57(4), pp. 541-546. (PMID:21140004)

Botlagunta, M. et al. (2008) Oncogenic role of DDX3 in breast cancer biogenesis. Oncogene, 27, pp. 3912-3922. (doi: 10.1038/onc.2008.33) (PMID:18264132)

Witteveldt, J., Vieyres, G. and Patel, A.H. (2007) HCV requires a tight junction-associated protein for cell entry. Future Virology, 2(4), pp. 335-338. (doi: 10.2217/17460794.2.4.335)

Owsianka, A.M. and Patel, A.H. (1999) Hepatitis C virus core protein interacts with a human DEAD box protein DDX3. Virology, 257(2), pp. 330-340. (doi: 10.1006/viro.1999.9659)

Patel, A.H. and MacLean, J.B. (1995) The product of the UL6 gene of herpes simplex virus type 1 is associated with virus capsids. Virology, 206(1), pp. 465-478. (doi: 10.1016/s0042-6822(95)80062-x)

Patel, A.H. and Elliott, R.M. (1992) Characterization of Bunyamwera virus defective interfering particles. Journal of General Virology, 73(2), pp. 389-396. (doi: 10.1099/0022-1317-73-2-389)

Foster, T.J., O'Reilly, M., Patel, A.H. and Bramley, A.J. (1988) Genetic studies of Staphylococcus aureus virulence factors. Antonie van Leeuwenhoek, 54(5), pp. 475-482. (doi: 10.1007/bf00461866)

Book Sections

This list was generated on Mon Apr 15 14:01:49 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

MonkeyPox - Rapid Response
Biotechnology and Biological Sciences Research Council
2022 - 2023
Genotype to Phenotype Consortium
UK Research and Innovation
2021 - 2023
COVID-19: Screening of ReFRAME collection
Bill and Melinda Gates Foundation
2020 - 2020
Vaccines and molecular tools for the control of the emerging bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV)
Biotechnology and Biological Sciences Research Council
2018 - 2021
Design, development and GMP manufacture of a Zika vaccine
Department of Health
2016 - 2020
Quinquennial Core Funds
Medical Research Council
2016 - 2021
Characterisation of Zika virus neutralisation and virion structure by cryogenic electron microscopy and 3D reconstruction.
Medical Research Council
2016 - 2017
Basis of the host range and tissue tropism for hepatitis C virus
Medical Research Council
2013 - 2016
Establishment of a Resource for Long-Term Study of Hepatitis C Virus Infection in the UK
Medical Research Foundation
2013 - 2016
Development of Novel in Vitro Models for Hepatitus B virus and Hepatitus C virus Infection and Replication
Medical Research Council
2012 - 2013

Research datasets

Jump to: 2023 | 2022 | 2020

Number of items: 3.

2023

Meehan, G. , Herder, V. , Allan, J., Huang, X., Kerr, K., Correa Mendonca, D. , Ilia, G., Wright, D. , Nomikou, K., Gu, Q. , Molina Arias, S., Hansmann, F., Hardas, A., Attipa, C., De Lorenzo, G. , Cowton, V., Upfold, N. , Palmalux, N., Brown, J., Barclay, W., Da Silva Filipe, A. , Furnon, W. , Patel, A. and Palmarini, M. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. [Data Collection]

2022

Bryden, S. , Dunlop, J., Clarke, A., Fares, M. , Pingen, M., Wu, Y., Willett, B. , Patel, A. , Gao, G., Kohl, A. and Brennan, B. (2022) Elucidation of the immunological responses underpinning severe fever with thrombocytopenia syndrome reveals IL-6 as novel therapeutic target. [Data Collection]

2020

Sanchez Velazquez, R., de Lorenzo, G., Tandavanitj, R., Setthapramote, C., Bredenbeek, P., Bozzacco, L., MacDonald, M., Clark, J., Rice, C., Patel, A. , Kohl, A. and Varjak, M. (2020) Generation of a reporter yellow fever virus for high throughput antiviral assays. [Data Collection]

This list was generated on Mon Apr 15 17:04:05 2024 BST.

Arvind Patel

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Professor Arvind Patel

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