The Thomson Group

The Thomson Group


Dr Emma Thomson

  • Clinical Senior Lecturer (Centre for Virus Research)
  • CLINICAL SENIOR LECTURER (School of Medicine, Dentistry and Nursing)

telephone: 01413302928
email: Emma.Thomson@glasgow.ac.uk

Research interests

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Hepatitis C virus infects 185 million people around the world and is a major cause of liver disease, including liver cancer. At present, there is no vaccine and treatment is toxic, expensive and only partially effective. Around 1 in 4 of people clear the infection spontaneously while the majority become chronically infected and 1 in 4 of these will develop cirrhosis of the liver.

The main aim of my research is to investigate the mechanisms behind spontaneous clearance and progression to chronicity in order to advance the search for an effective HCV vaccine. Studies in this area have previously been limited due to lack of clinical symptoms during early infection. I follow a large cohort of patients in Glasgow and London who have been identified with early infection and who have been recruited and followed-up regularly following diagnosis (Acute HCV UK).

The current focus of my work is to identify novel B and T cell epitopes recognised during acute HCV infection using next-generation sequencing of the entire viral genome and functional assays including flow cytometry, ELISpots, neutralisation assays and replicon systems. This project is funded by a Wellcome Trust clinical intermediate fellowship.

I work as an infectious diseases consultant with specialist interests in early hepatitis C infection and hepatitis C and HIV co-infection at Gartnavel Hospital, Glasgow and at St Mary’s Hospital, Imperial College London. I am a member of the British HIV Association Hepatitis Group and work as an external consultant for the World Health Organisation. Recently I have been involved in writing the WHO Guidelines for the Care, Screening and Treatment of Hepatitis C, 2014.

Research in my lab is supported through two major grants:

  • Wellcome Trust Clinical Intermediate Fellowship: 2014 - 2018
  • MRC Stratified Medicine Award - STOP HCV: 2013 - 2018

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • T-cell mediated evolution of hepatitis C virus during acute infection
    Wellcome Trust
    2014 - 2018
     
  • Stratified medicine to Optimise the Treatment with Hepatitis C Virus Infection (STOP-HCV)
    Medical Research Council
    2013 - 2018
     
  • Relapse after treatment for acute HCV infection in HIV-positive men; viral recrudescence or reinfection?
    British HIV Association
    2011 - 2013
     

Publications

List by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2004 | 2003
Number of items: 28.

2016

Martin, N. K. et al. (2016) Can HCV direct-acting antiviral treatment as prevention reverse the HCV epidemic amongst men who have sex with men in the UK - epidemiological and modelling insights. Clinical Infectious Diseases, 62(9), pp. 1072-1080. (doi:10.1093/cid/ciw075) (PMID:26908813) (PMCID:PMC4826456)

Swann, R. E., Cowton, V. M., Robinson, M. W., Cole, S. J., Barclay, S. T., Mills, P. R., Thomson, E. c., McLauchlan, J., and Patel, A. (2016) Broad anti-hepatitis C virus (HCV) antibody responses are associated with improved clinical disease parameters in chronic HCV infection. Journal of Virology, 90(9), pp. 4530-4543. (doi:10.1128/JVI.02669-15) (PMID:26912610)

Robinson, M. W., Hughes, J., Wilkie, G. S., Swann, R., Barclay, S. T., Mills, P. R., Patel, A. H., Thomson, E. C., and McLauchlan, J. (2016) Tracking TCRß sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region. Frontiers in Immunology, 7, 131. (doi:10.3389/fimmu.2016.00131) (PMID:27092143) (PMCID:PMC4820669)

Padam, P., Clark, S., Irving, W., Gellissen, R., Thomson, E., Main, J., and Cooke, G.S. (2016) Reduced healthcare utilization following successful hepatitis C virus treatment in HIV-co-infected patients with mild liver disease. Journal of Viral Hepatitis, 23(2), pp. 123-129. (doi:10.1111/jvh.12484) (PMID:26511293)

Martin, F., Lee, J., Thomson, E., Tarrant, N., Hale, A., and Lacey, C. J. (2016) Two cases of possible transmitted drug resistant HIV virus: likely HIV superinfection and unmasking of pre-existing resistance. International Journal of STD and AIDS, 27(1), pp. 66-69. (doi:10.1177/0956462415571671) (PMID:25663247)

Thomson, E. (2016) A case of late Ebola virus relapse causing meningo-encephalitis. Lancet, (Accepted for Publication)

2015

Gaunt, E., Harvala, H., Osterback, R., Sreenu, V. B., Thomson, E., Waris, M., and Simmonds, P. (2015) Genetic characterization of human coxsackievirus A6 variants associated with atypical hand, foot and mouth disease: a potential role of recombination in emergence and pathogenicity. Journal of General Virology, 96(5), pp. 1067-1079. (doi:10.1099/vir.0.000062) (PMID:25614593)

Abdelrahman, T., Hughes, J., Main, J., McLauchlan, J., Thursz, M., and Thomson, E. (2015) Reply. Hepatology, 61(4), p. 1438. (doi:10.1002/hep.27393) (PMID:25147121) (PMCID:PMC4407921)

Ardelrahman, T., Hughes, J., Main, J., McLauchlan, J., Thursz, M., and Thomson, E. (2015) Waiting time and transplantation for hepatocellular cancer: a balance between tempus fugit and carpe diem. Hepatology, 61(4), pp. 1438-1439. (doi:10.1002/hep.27434)

Shepherd, S. J., Abdelrahman, T., MacLean, A. R., Thomson, E. C., Aitken, C., and Gunson, R. N. (2015) Prevalence of HCV NS3 pre-treatment resistance associated amino acid variants within a Scottish cohort. Journal of Clinical Virology, 65, pp. 50-53. (doi:10.1016/j.jcv.2015.02.005) (PMID:25766988)

Abdelrahman, T., Hughes, J., Main, J., McLauchlan, J., Thursz, M., and Thomson, E. (2015) Next generation sequencing sheds light on the natural history of hepatitis C infection in patients that fail treatment. Hepatology, 61(1), pp. 88-97. (doi:10.1002/hep.27192) (PMID:24797101) (PMCID:PMC4303934)

2014

McNaughton, A.L., Thomson, E.C., Templeton, K., Gunson, R.N., and McWilliam Leitch, E.C. (2014) Mixed genotype hepatitis C infections and implications for treatment. Hepatology, 59(3), p. 1209. (doi:10.1002/hep.26544) (PMID:23744801) (PMCID:PMC4296219)

2013

Leggewie, M., Vattipally, S.B., Abdelrahman, T., Leitch, E. C., Wilkie, G., Klymenko, T., Muir, D., Thursz, M., Main, J., and Thomson, E.C. (2013) Natural NS3 resistance polymorphisms occur frequently prior to treatment in HIV-positive patients with acute hepatitis C. AIDS, 27(15), pp. 2485-2488. (doi:10.1097/QAD.0b013e328363b1f9) (PMID:23770494)

2011

Thomson, E.C., Smith, J.A., and Klenerman, P. (2011) The natural history of early hepatitis C virus evolution; lessons from a global outbreak in human immunodeficiency virus-1-infected individuals. Journal of General Virology, 92(10), pp. 2227-2236. (doi:10.1099/vir.0.033910-0)

Thomson, E.C., Fleming, V.M., Main, J., Klenerman, P., Weber, J., Eliahoo, J., Smith, J., McClure, M.O., and Karayiannis, P. (2011) Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men. Gut, 60(6), pp. 837-845. (doi:10.1136/gut.2010.217166)

2010

Huang, K.-H.G. et al. (2010) B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection. Nature Communications, 1, p. 102. (doi:10.1038/ncomms1100)

Smith, J.A., Aberle, J.H., Fleming, V.M., Ferenci, P., Thomson, E.C., Karayiannis, P., McLean, A.R., Holzmann, H., and Klenerman, P. (2010) Dynamic coinfection with multiple viral subtypes in acute hepatitis C. Journal of Infectious Diseases, 202(12), pp. 1770-1779. (doi:10.1086/657317)

Winston, A. et al. (2010) Does acute hepatitis C infection affect the central nervous system in HIV-1 infected individuals? Journal of Viral Hepatitis, 17(6), pp. 419-426. (doi:10.1111/j.1365-2893.2009.01198.x)

2009

Thomson, E.C., Nastouli, E., Main, J., Karayiannis, P., Eliahoo, J., Muir, D., and McClure, M.O. (2009) Delayed anti-HCV antibody response in HIV-positive men acutely infected with HCV. AIDS, 23(1), pp. 89-93. (doi:10.1097/QAD.0b013e32831940a3)

Nastouli, E., Thomson, E.C., Karayiannis, P., Main, J., McClure, M., and Muir, D. (2009) Diagnosing acute hepatitis C in HIV-infected patients: nucleic acid testing compared with antibody and antigen-antibody detecting methods. Journal of Clinical Virology, 44(1), pp. 78-80. (doi:10.1016/j.jcv.2008.09.008)

2008

Fox, J., Nastouli, E., Thomson, E.C., Muir, D., McClure, M., Weber, J., and Fidler, S. (2008) Increasing incidence of acute hepatitis C in individuals diagnosed with primary HIV in the United Kingdom. AIDS, 22(5), pp. 666-668. (doi:10.1097/QAD.0b013e3282f5f4cf)

Thomson, E.C., and Main, J. (2008) Epidemiology of hepatitis C virus infection in HIV-infected individuals. Journal of Viral Hepatitis, 15(11), pp. 773-781. (doi:10.1111/j.1365-2893.2008.00981.x)

2007

Garvey, L., Thomson, E.C., Main, J., and Winston, A. (2007) Response to "Persistence of neuropsychologic deficits despite long-term highly active antiretroviral therapy in patients with HIV-related neurocognitive impairment". JAIDS: Journal of Acquired Immune Deficiency Syndromes, 46(5), pp. 656-657. (doi:10.1097/QAI.0b013e318157b0c8)

Garvey, L.J., Thomson, E.C., Lloyd, J., Cooke, G.S., Goldin, R.D., and Main, J. (2007) Response to Mallet et al., 'Nodular regenerative hyperplasia is a new cause of chronic liver disease in HIV-infected patients'. AIDS, 21(11), pp. 1494-1495. (doi:10.1097/QAD.0b013e3281e7ed64)

2006

Bloom, C., Thomson, E.C., and Main, J. (2006) An elderly lady with sudden blindness and a sore foot. Journal of Infection, 52(2), e53-e54. (doi:10.1016/j.jinf.2005.05.002)

Garvey, L., Thomson, E.C., and Taylor, G.P. (2006) Progressive multifocal leukoencephalopathy: prolonged survival in patients treated with protease inhibitors and cidofovir: a case series. AIDS, 20(5), pp. 791-793. (doi:10.1097/01.aids.0000216390.83351.87)

2004

Thomson, E.C., and Main, J. (2004) Advances in hepatitis B and C. Current Opinion in Infectious Diseases, 17(5), pp. 449-459.

2003

Thomson, E.C., and Lynn, W.A. (2003) Septic thrombophlebitis with multiple pulmonary abscesses. Lancet Infectious Diseases, 3(2), p. 86. (doi:10.1016/S1473-3099(03)00516-4)

This list was generated on Fri Jul 29 01:54:00 2016 BST.
Jump to: Articles
Number of items: 28.

Articles

Martin, N. K. et al. (2016) Can HCV direct-acting antiviral treatment as prevention reverse the HCV epidemic amongst men who have sex with men in the UK - epidemiological and modelling insights. Clinical Infectious Diseases, 62(9), pp. 1072-1080. (doi:10.1093/cid/ciw075) (PMID:26908813) (PMCID:PMC4826456)

Swann, R. E., Cowton, V. M., Robinson, M. W., Cole, S. J., Barclay, S. T., Mills, P. R., Thomson, E. c., McLauchlan, J., and Patel, A. (2016) Broad anti-hepatitis C virus (HCV) antibody responses are associated with improved clinical disease parameters in chronic HCV infection. Journal of Virology, 90(9), pp. 4530-4543. (doi:10.1128/JVI.02669-15) (PMID:26912610)

Robinson, M. W., Hughes, J., Wilkie, G. S., Swann, R., Barclay, S. T., Mills, P. R., Patel, A. H., Thomson, E. C., and McLauchlan, J. (2016) Tracking TCRß sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region. Frontiers in Immunology, 7, 131. (doi:10.3389/fimmu.2016.00131) (PMID:27092143) (PMCID:PMC4820669)

Padam, P., Clark, S., Irving, W., Gellissen, R., Thomson, E., Main, J., and Cooke, G.S. (2016) Reduced healthcare utilization following successful hepatitis C virus treatment in HIV-co-infected patients with mild liver disease. Journal of Viral Hepatitis, 23(2), pp. 123-129. (doi:10.1111/jvh.12484) (PMID:26511293)

Martin, F., Lee, J., Thomson, E., Tarrant, N., Hale, A., and Lacey, C. J. (2016) Two cases of possible transmitted drug resistant HIV virus: likely HIV superinfection and unmasking of pre-existing resistance. International Journal of STD and AIDS, 27(1), pp. 66-69. (doi:10.1177/0956462415571671) (PMID:25663247)

Thomson, E. (2016) A case of late Ebola virus relapse causing meningo-encephalitis. Lancet, (Accepted for Publication)

Gaunt, E., Harvala, H., Osterback, R., Sreenu, V. B., Thomson, E., Waris, M., and Simmonds, P. (2015) Genetic characterization of human coxsackievirus A6 variants associated with atypical hand, foot and mouth disease: a potential role of recombination in emergence and pathogenicity. Journal of General Virology, 96(5), pp. 1067-1079. (doi:10.1099/vir.0.000062) (PMID:25614593)

Abdelrahman, T., Hughes, J., Main, J., McLauchlan, J., Thursz, M., and Thomson, E. (2015) Reply. Hepatology, 61(4), p. 1438. (doi:10.1002/hep.27393) (PMID:25147121) (PMCID:PMC4407921)

Ardelrahman, T., Hughes, J., Main, J., McLauchlan, J., Thursz, M., and Thomson, E. (2015) Waiting time and transplantation for hepatocellular cancer: a balance between tempus fugit and carpe diem. Hepatology, 61(4), pp. 1438-1439. (doi:10.1002/hep.27434)

Shepherd, S. J., Abdelrahman, T., MacLean, A. R., Thomson, E. C., Aitken, C., and Gunson, R. N. (2015) Prevalence of HCV NS3 pre-treatment resistance associated amino acid variants within a Scottish cohort. Journal of Clinical Virology, 65, pp. 50-53. (doi:10.1016/j.jcv.2015.02.005) (PMID:25766988)

Abdelrahman, T., Hughes, J., Main, J., McLauchlan, J., Thursz, M., and Thomson, E. (2015) Next generation sequencing sheds light on the natural history of hepatitis C infection in patients that fail treatment. Hepatology, 61(1), pp. 88-97. (doi:10.1002/hep.27192) (PMID:24797101) (PMCID:PMC4303934)

McNaughton, A.L., Thomson, E.C., Templeton, K., Gunson, R.N., and McWilliam Leitch, E.C. (2014) Mixed genotype hepatitis C infections and implications for treatment. Hepatology, 59(3), p. 1209. (doi:10.1002/hep.26544) (PMID:23744801) (PMCID:PMC4296219)

Leggewie, M., Vattipally, S.B., Abdelrahman, T., Leitch, E. C., Wilkie, G., Klymenko, T., Muir, D., Thursz, M., Main, J., and Thomson, E.C. (2013) Natural NS3 resistance polymorphisms occur frequently prior to treatment in HIV-positive patients with acute hepatitis C. AIDS, 27(15), pp. 2485-2488. (doi:10.1097/QAD.0b013e328363b1f9) (PMID:23770494)

Thomson, E.C., Smith, J.A., and Klenerman, P. (2011) The natural history of early hepatitis C virus evolution; lessons from a global outbreak in human immunodeficiency virus-1-infected individuals. Journal of General Virology, 92(10), pp. 2227-2236. (doi:10.1099/vir.0.033910-0)

Thomson, E.C., Fleming, V.M., Main, J., Klenerman, P., Weber, J., Eliahoo, J., Smith, J., McClure, M.O., and Karayiannis, P. (2011) Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men. Gut, 60(6), pp. 837-845. (doi:10.1136/gut.2010.217166)

Huang, K.-H.G. et al. (2010) B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection. Nature Communications, 1, p. 102. (doi:10.1038/ncomms1100)

Smith, J.A., Aberle, J.H., Fleming, V.M., Ferenci, P., Thomson, E.C., Karayiannis, P., McLean, A.R., Holzmann, H., and Klenerman, P. (2010) Dynamic coinfection with multiple viral subtypes in acute hepatitis C. Journal of Infectious Diseases, 202(12), pp. 1770-1779. (doi:10.1086/657317)

Winston, A. et al. (2010) Does acute hepatitis C infection affect the central nervous system in HIV-1 infected individuals? Journal of Viral Hepatitis, 17(6), pp. 419-426. (doi:10.1111/j.1365-2893.2009.01198.x)

Thomson, E.C., Nastouli, E., Main, J., Karayiannis, P., Eliahoo, J., Muir, D., and McClure, M.O. (2009) Delayed anti-HCV antibody response in HIV-positive men acutely infected with HCV. AIDS, 23(1), pp. 89-93. (doi:10.1097/QAD.0b013e32831940a3)

Nastouli, E., Thomson, E.C., Karayiannis, P., Main, J., McClure, M., and Muir, D. (2009) Diagnosing acute hepatitis C in HIV-infected patients: nucleic acid testing compared with antibody and antigen-antibody detecting methods. Journal of Clinical Virology, 44(1), pp. 78-80. (doi:10.1016/j.jcv.2008.09.008)

Fox, J., Nastouli, E., Thomson, E.C., Muir, D., McClure, M., Weber, J., and Fidler, S. (2008) Increasing incidence of acute hepatitis C in individuals diagnosed with primary HIV in the United Kingdom. AIDS, 22(5), pp. 666-668. (doi:10.1097/QAD.0b013e3282f5f4cf)

Thomson, E.C., and Main, J. (2008) Epidemiology of hepatitis C virus infection in HIV-infected individuals. Journal of Viral Hepatitis, 15(11), pp. 773-781. (doi:10.1111/j.1365-2893.2008.00981.x)

Garvey, L., Thomson, E.C., Main, J., and Winston, A. (2007) Response to "Persistence of neuropsychologic deficits despite long-term highly active antiretroviral therapy in patients with HIV-related neurocognitive impairment". JAIDS: Journal of Acquired Immune Deficiency Syndromes, 46(5), pp. 656-657. (doi:10.1097/QAI.0b013e318157b0c8)

Garvey, L.J., Thomson, E.C., Lloyd, J., Cooke, G.S., Goldin, R.D., and Main, J. (2007) Response to Mallet et al., 'Nodular regenerative hyperplasia is a new cause of chronic liver disease in HIV-infected patients'. AIDS, 21(11), pp. 1494-1495. (doi:10.1097/QAD.0b013e3281e7ed64)

Bloom, C., Thomson, E.C., and Main, J. (2006) An elderly lady with sudden blindness and a sore foot. Journal of Infection, 52(2), e53-e54. (doi:10.1016/j.jinf.2005.05.002)

Garvey, L., Thomson, E.C., and Taylor, G.P. (2006) Progressive multifocal leukoencephalopathy: prolonged survival in patients treated with protease inhibitors and cidofovir: a case series. AIDS, 20(5), pp. 791-793. (doi:10.1097/01.aids.0000216390.83351.87)

Thomson, E.C., and Main, J. (2004) Advances in hepatitis B and C. Current Opinion in Infectious Diseases, 17(5), pp. 449-459.

Thomson, E.C., and Lynn, W.A. (2003) Septic thrombophlebitis with multiple pulmonary abscesses. Lancet Infectious Diseases, 3(2), p. 86. (doi:10.1016/S1473-3099(03)00516-4)

This list was generated on Fri Jul 29 01:54:00 2016 BST.

Research group members

Tamer Abdelrahman
Clinical Lecturer

Walt Adamson
Research Associate

Naomi Bulteel
Clinical Research Fellow

Chris Davis
Research Associate

Hanna Jerome
Research Associate

Elizabeth Spence
Research Nurse

Sultan Al-Otaibi
PhD student [email]

Weronika Witkowska
PhD student [email]

 

Emma Thomson research

Research programme: 

Our work focuses on hepatitis C virus diversity during transmission and early intrahost viral evolution using next-gen and full length sequencing of the viral genome; and to understand why the immune response to HCV fails in some individuals, including those with HIV co-infection.

Current research

Collaborators

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