Like other groups of arboviruses, the transmission cycle of bunyaviruses involves replication in a blood-feeding arthropod and a vertebrate host. The family includes a number of pathogens of clinical and veterinary significance as well as recently emerged viruses.
Our ultimate aim is to understand the intimate molecular details of virus replication in these disparate cell types that account for the different outcomes of infection using a multidisciplinary approach, and selected important representative viruses.
We created a recombinant Rift Valley fever virus with the N and NSs coding sequences swapped around on the S segment (Brennan et al., 2014).
Together with collaborators in Brazil, we corrected the genome sequence of Oropouche virus and established of a minigenome system (Acrani et al., 2015).
Also with these collaborators we produced a detailed phylogenetic analysis of the Oropouche virus species and description of a novel reassortant virus in Brazil (Tilston-Lunel et al., 2015).
We established a reverse genetics systems for severe fever with thrombocytopenia syndrome virus with colleagues in China (Brennan et al., 2015), and for Uukuniemi virus with Ana Överby in Sweden (Rezelj et al., 2015).