Institute of Cardiovascular and Medical Sciences

Dr Tom Van Agtmael

  • Lecturer (Institute of Cardiovascular and Medical Sciences)
  • Associate Academic (Institute of Molecular Cell and Systems Biology)

telephone: 01413306200
email: Tom.VanAgtmael@glasgow.ac.uk


Dr. Van Agtmael obtained his PhD at the Murdoch Childrens Research Insititute in Melbourne (Australia) investigating the genetics of human handedness. He then moved to the MRC Human Genetics Unit in Edinburgh for his post-doctoral training as an EU Marie Curie Fellow during which he identified the first vertebrate Col4a1 mutations and implicated type IV collagen in anterior segment dysgenesis. Following a CVRI Wellcome Trust Fellowship at the University of Edinburgh, he was awarded a MRC New Investigator Research Grant to investigate the role of collagen IV in vascular biology. He then joined the University of Glasgow and is currently a RCUK Fellow in Human Molecular Genetics.

His research focuses on the role of the basement membrane and the extracellular matrix in human disease and, in particular collagen IV. To this end a multi-disciplinary approach is utilised encompassing animal and human genetics, physiology, tissue culture as well as molecular and cellular approaches.

 

List all by: Type | Date

Jump to: 2013 | 2011 | 2010 | 2009 | 2007 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 12.

2013

Murray, L.S., Lu, Y., Taggart, A., Van Regemorter, N., Vilain, C., Abramowicz, M., Kadler, K.E., and Van Agtmael, T. (2013) Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke. Human Molecular Genetics . ISSN 0964-6906 (doi:10.1093/hmg/ddt418) (In Press)

2011

Agarwal, S., Taylor, S.H., Al-Youha, S., Van Agtmael, T., Lu, Y., Wong, J., McGrouther, D.A., and Kadler, K.E. (2011) Tendon is covered by a basement membrane epithelium that is required for cell retention and the prevention of adhesion formation. PLoS ONE, 6 (1). e16337. ISSN 1932-6203 (doi:10.1371/journal.pone.0016337)

2010

Van Agtmael, T., Bailey, M.A., Schlotzer-Schrehardt, U., Craigie, E., Jackson, I.J., Brownstein, D.G., Megson, I.L., and Mullins, J.J. (2010) Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume. Human Molecular Genetics, 19 (6). pp. 1119-1128. ISSN 0964-6906 (doi:10.1093/hmg/ddp584)

Van Agtmael, T., and Bruckner-Tuderman, L. (2010) Basement membranes and human disease. Cell and Tissue Research, 339 (1). pp. 167-188. ISSN 0302-766X (doi:10.1007/s00441-009-0866-y)

Van Agtmael, T., and Bruckner-Tuderman, L. (2010) Basement membranes and human disease. Cell and Tissue Research, 339 (1). pp. 167-168. ISSN 0302-766X (doi:10.1007/s00441-009-0866-y)

2009

Alamowitch, S., Plaisier, E., Favrole, P., Prost, C., Chen, Z., Van Agtmael, T., Marro, B., and Ronco, P. (2009) Cerebrovascular disease related to COL4A1 mutations in HANAC syndrome. Neurology, 73 (22). pp. 1873-1882. ISSN 0028-3878 (doi:10.1212/WNL.0b013e3181c3fd12)

2007

Plaisier, E. et al. (2007) COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. New England Journal of Medicine, 357 (26). pp. 2687-2695. ISSN 0028-4793

2005

Van Agtmael, T (2005) Dominant mutations of Col4a1 result in basement membrane defects which lead to anterior segment dysgenesis and glomerulopathy. Human Molecular Genetics, 14 (21). pp. 3161-3168. (doi:10.1093/hmg/ddi348)

2004

Van Agtmael, T (2004) 17th International Mouse Genome Conference. Mammalian Genome, 15 (7). pp. 509-514. (doi:10.1007/s00335-004-4001-9)

2003

Van Agtmael, T (2003) Parametric and nonparametric genome scan analyses for human handedness. European Journal of Human Genetics, 11 (10). pp. 779-783. (doi:10.1038/sj.ejhg.5201048)

2002

Van Agtmael, T (2002) Parametric and non-parametric linkage analysis of several candidate regions for genes for human handedness. European Journal of Human Genetics, 10 (10). pp. 623-630. (doi:10.1038/sj.ejhg.5200851)

2001

Van Agtmael, T (2001) Genes for left-handedness: How to search for the needle in the haystack? Laterality: Asymmetries of Body, Brain and Cogniti, 6 (2). pp. 149-164. (doi:10.1080/713754403)

This list was generated on Wed Oct 2 07:17:10 2013 BST.
Jump to: Article
Number of items: 12.

Article

Murray, L.S., Lu, Y., Taggart, A., Van Regemorter, N., Vilain, C., Abramowicz, M., Kadler, K.E., and Van Agtmael, T. (2013) Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke. Human Molecular Genetics . ISSN 0964-6906 (doi:10.1093/hmg/ddt418) (In Press)

Agarwal, S., Taylor, S.H., Al-Youha, S., Van Agtmael, T., Lu, Y., Wong, J., McGrouther, D.A., and Kadler, K.E. (2011) Tendon is covered by a basement membrane epithelium that is required for cell retention and the prevention of adhesion formation. PLoS ONE, 6 (1). e16337. ISSN 1932-6203 (doi:10.1371/journal.pone.0016337)

Van Agtmael, T., Bailey, M.A., Schlotzer-Schrehardt, U., Craigie, E., Jackson, I.J., Brownstein, D.G., Megson, I.L., and Mullins, J.J. (2010) Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume. Human Molecular Genetics, 19 (6). pp. 1119-1128. ISSN 0964-6906 (doi:10.1093/hmg/ddp584)

Van Agtmael, T., and Bruckner-Tuderman, L. (2010) Basement membranes and human disease. Cell and Tissue Research, 339 (1). pp. 167-188. ISSN 0302-766X (doi:10.1007/s00441-009-0866-y)

Van Agtmael, T., and Bruckner-Tuderman, L. (2010) Basement membranes and human disease. Cell and Tissue Research, 339 (1). pp. 167-168. ISSN 0302-766X (doi:10.1007/s00441-009-0866-y)

Alamowitch, S., Plaisier, E., Favrole, P., Prost, C., Chen, Z., Van Agtmael, T., Marro, B., and Ronco, P. (2009) Cerebrovascular disease related to COL4A1 mutations in HANAC syndrome. Neurology, 73 (22). pp. 1873-1882. ISSN 0028-3878 (doi:10.1212/WNL.0b013e3181c3fd12)

Plaisier, E. et al. (2007) COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. New England Journal of Medicine, 357 (26). pp. 2687-2695. ISSN 0028-4793

Van Agtmael, T (2005) Dominant mutations of Col4a1 result in basement membrane defects which lead to anterior segment dysgenesis and glomerulopathy. Human Molecular Genetics, 14 (21). pp. 3161-3168. (doi:10.1093/hmg/ddi348)

Van Agtmael, T (2004) 17th International Mouse Genome Conference. Mammalian Genome, 15 (7). pp. 509-514. (doi:10.1007/s00335-004-4001-9)

Van Agtmael, T (2003) Parametric and nonparametric genome scan analyses for human handedness. European Journal of Human Genetics, 11 (10). pp. 779-783. (doi:10.1038/sj.ejhg.5201048)

Van Agtmael, T (2002) Parametric and non-parametric linkage analysis of several candidate regions for genes for human handedness. European Journal of Human Genetics, 10 (10). pp. 623-630. (doi:10.1038/sj.ejhg.5200851)

Van Agtmael, T (2001) Genes for left-handedness: How to search for the needle in the haystack? Laterality: Asymmetries of Body, Brain and Cogniti, 6 (2). pp. 149-164. (doi:10.1080/713754403)

This list was generated on Wed Oct 2 07:17:10 2013 BST.

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Elucidation of molecular pathways underlying renal disease caused by Co/4a 1 mutations using mouse models.
    Kidney Research UK
    2013 - 2015
     
  • New Investigator Research Grant
    MRC
    2007 - 2010
     
  • RCUK Academic Fellowship - IBLS
    EPSRC
    2007 - 2012
     

Invited International Presentations

  • 2012: Melbourne, Australia - Invited seminar speaker, Faculty of Medicine, Northern Hospital, University of Melbourne
  • 2012: Melbourne, Australia - Invited seminar speaker, Murdoch Childrens Research Institute
  • 2012: Oxford, England, UK - Joint Meeting of the British and German Societies for Matrix Biology
  • 2011: Brussels, Belgium - Invited seminar speaker, Department of Medical Genetics Université Libre de Bruxelles - Erasmus Hospital
  • 2011: Scottish Society for Experimental Medicine
  • 2011: Leicester, England, UK - Invited seminar speaker, Cardiovascular Research Theme, University of Leicester
  • 2011: Bristol, England, UK - Invited seminar speaker, Department of Paediatric Neurology, Royal Hospital for Sick Children
  • 2011: Southampton, England, UK - Invited seminar speaker, Department of Medical Genetics, University of Southampton
  • 2010: Manchester, England, UK - British Society Matrix Biology Meeting
  • 2009: New Hampshire, USA - Invited speaker at the Collagen Gordon Conference
  • 2007: Oulu, Finland - Invited speaker, Biocenter Day University of Oulu
  • 2007: Paris, France - Invited seminar speaker, INSERM Unit, Tenon Hospital, Department of Nephrology
  • 2006: Manchester, England, UK - Invited seminar speaker, Wellcome Trust Centre for Cell-Matrix Biology
  • 2006: Glasgow, Scotland, UK - Invited speaker at the ERA-EDTA (European Renal Association) Conference
  • 2005: New Hampshire, USA - Invited speaker at the Collagen Gordon Conference
  • 2005: Paris, France - Invited seminar speaker, INSERM Unit, Tenon Hospital, Department of Nephrology
  • 2005: Strasbourg, France - International Mouse Genome Conference
  • 2004: Rhode Island, USA - Invited speaker at the Basement Membrane Gordon Conference

Professional Learned Society

  • 2012 - ongoing: British Society for Matrix Biology - Committee Member
  • 2011 - ongoing: Genetics Society - Member
  • 2010 - ongoing: British Society for Matrix Biology - Member
  • 2007 - ongoing: International Society of Matrix Biology - Member

Research Fellowship

  • 2007 - 2012: Research Councils UK Academic Fellowship
  • 2004 - 2007: Wellcome Trust CVRI Fellow
  • 2002 - 2004: EU Marie Curie Fellow