Dr Scott Mackenzie

  • Lecturer (Cardiovascular & Metabolic Health)

telephone: 01413302669
email: Scott.MacKenzie@glasgow.ac.uk

Rm C437, BHF Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow, G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-4593-4101

Biography

My core research investigates the cardiovascular impact of the steroid hormones aldosterone and cortisol, particularly the regulation of their production by the adrenal gland. Loss of this tightly-controlled process has severe consequences for the vascular system, including hypertension, and damage to the heart and kidneys. Much of my work has focused on how common genetic variations leads to overproduction of these steroids, predisposing large sections of the population to high blood pressure, which often goes undiagnosed and untreated, despite the availability of effective treatments. To this end, I have contributed to several large-scale genetic studies identifying polymorphisms at steroidogenic loci that could aid diagnosis and therapeutic targeting of specific subtypes of hypertension. My work also includes investigation of the mechanisms by which these polymorphisms exert their effects, including studies of transcriptional activity, promoter binding, mRNA quantification and microRNA regulation. I am currently developing an interest in stress and its impact on cardiovascular disease through aldosterone secretion.

My research has a truly translational approach, encompassing laboratory analysis of isolated cells, investigation of tissue samples and full clinical studies. As an example of the latter, I am currently involved in the Europe-wide HT-ADVANCE study, which is using ‘omics’ approaches to develop diagnostic signatures for various endocrine forms of hypertension. To this end, I am involved in analysing levels of circulating microRNAs in hypertensive patients recruited in Glasgow and throughout Europe. As well as developing improved procedures to more effectively diagnose patients with such conditions as Primary Aldosteronism or Cushing’s Disease, it is highly likely that this project will yield mechanistic insights into the regulation and action of aldosterone and cortisol in health and disease.

I have productive research projects with numerous colleagues within the University of Glasgow, while my past and present external collaborators include Professor John Connell at the University of Dundee, Dr Trevor Bushell at Strathclyde University, Professor Maria-Christina Zennaro at INSERM, Paris and Professor William Rainey at the University of Mississippi. I have received research funding from the European Union, the Chief Scientist Office and the British Heart Foundation and I am a former RCUK and Hypertension Trust Research Fellow. Such funding has enabled my colleagues, students and myself to maintain an active record of publishing in prominent journals such as Circulation, Nature and Hypertension over the last 25 years.

I am active in various professional consortia and societies, including the Society for Endocrinology, where I have been a longstanding member elected to its Science Committee, co-convenor of its Adrenal and Cardiovascular Network and leader of its Career Development Workshop, which is the Society’s main initiative for promoting the early career researchers among its 2,600 members. I am a reviewer for funding bodies including the Medical Research Council and British Heart Foundation, and for journals including Endocrinology, Clinical Endocrinology and Hypertension.

Within the School of Cardiovascular & Metabolic Health, I currently hold the roles of Biological Safety Officer and Deputy Chair of the Athena Swan Committee.

Research interests

Research Theme: Vascular Diseases and Comorbidities

Our group’s core research investigates the production of the steroid hormones aldosterone and cortisol by the cortex of the adrenal gland. In particular, we wish to understand how genetic variation between individuals influences the regulation of these steroids’ production and how this results in high blood pressure. To this end, I have contributed to several large-scale genetic studies involving our main genes of interest, aldosterone synthase and 11β-hydroxylase.

More recently, this interest in gene regulation has extended into microRNAs and their impact on steroid production by the adrenal gland and on steroid action in tissues such as blood vessels, the heart and the brain. As noted above, a major part of our research is also now concerned with the monitoring of levels of microRNAs in the bloodstream in order to see whether they can be used as part of a diagnostic test for conditions such as primary aldosteronism, thereby improving patient outcomes and reducing healthcare costs. This work is currently undergoing clinical trials as part of the HT-ADVANCE project, which follows on from the successful ENS@T-HT project, both funded by EU Horizon/UKRI.

Research groups

Publications

List by: Type | Date

Jump to: 2023 | 2022 | 2021 | 2019 | 2018 | 2017 | 2016 | 2013 | 2012 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2000
Number of items: 42.

2023

MacKenzie, S. M. , Birch, L. A., Lamprou, S., Rezvanisanijouybari, P., Fayad, M., Zennaro, M.-C. and Davies, E. (2023) MicroRNAs in aldosterone production and action. In: Vitamins and Hormones. Series: Vitamins and hormones. Elsevier. (doi: 10.1016/bs.vh.2023.07.001) (In Press)

2022

Reel, P. S. et al. (2022) Machine learning for classification of hypertension subtypes using multi-omics: a multi-centre, retrospective, data-driven study. EBioMedicine, 84, 104276. (doi: 10.1016/j.ebiom.2022.104276) (PMID:36179553) (PMCID:PMC9520210)

Moudio, S. et al. (2022) Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines. Psychopharmacology, 239(1), pp. 229-242. (doi: 10.1007/s00213-021-06040-1) (PMID:34888704) (PMCID:PMC8770450)

Armignacco, R. et al. (2022) Whole blood methylome-derived features to discriminate endocrine hypertension. Clinical Epigenetics, 14, 142. (doi: 10.1186/s13148-022-01347-y) (PMID:36329530) (PMCID:PMC9635165)

2021

MacKenzie, S. M. , Saunders, H., van Kralingen, J. C., Robertson, S. , Riddell, A. , Zennaro, M.-C. and Davies, E. (2021) Circulating microRNAs as diagnostic markers in primary aldosteronism. Cancers, 13(21), 5312. (doi: 10.3390/cancers13215312) (PMCID:PMC8582381)

2019

MacKenzie, S. M. , Nguyen Dinh Cat, A., van Kralingen, J. and Davies, E. (2019) Aldosterone. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 103-115. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_10)

MacKenzie, S. M. , Van Kralingen, J. C. and Davies, E. (2019) Regulation of aldosterone secretion. In: Litwack, G. (ed.) Aldosterone. Series: Vitamins and Hormones (109). Elsevier, pp. 241-263. ISBN 9780128177822 (doi: 10.1016/bs.vh.2018.07.001)

2018

McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137(1), pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911) (PMID:29030345) (PMCID:PMC5757664)

2017

Robertson, S., Diver, L. A., Alvarez-Madrazo, S., Livie, C., Ejaz, A., Fraser, R., Connell, J. M., MacKenzie, S. M. and Davies, E. (2017) Regulation of corticosteroidogenic genes by microRNAs. International Journal of Endocrinology, 2017, 2021903. (doi: 10.1155/2017/2021903) (PMID:28852406) (PMCID:PMC5568613)

MacKenzie, S. M. , Freel, M., Connell, J. M., Fraser, R. and Davies, E. (2017) ACTH and polymorphisms at steroidogenic loci as determinants of aldosterone secretion and blood pressure. International Journal of Molecular Sciences, 18(3), 579. (doi: 10.3390/ijms18030579) (PMID:28272372) (PMCID:PMC5372595)

MacKenzie, S. M. , Davies, E. and Alvarez-Madrazo, S. (2017) Analysis of the aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) genes. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 139-150. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_11)

2016

Abulkassim, R., Brett, R., MacKenzie, S. M. and Bushell, T. J. (2016) Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour. Journal of Neuroimmunology, 295-96, pp. 139-147. (doi: 10.1016/j.jneuroim.2016.04.016) (PMID:27235359)

Diver, L. A. et al. (2016) Common polymorphisms at the CYP17A1 locus associate with steroid phenotype: support for blood pressure genome-wide association study signals at this locus. Hypertension, 67(4), pp. 724-732. (doi: 10.1161/HYPERTENSIONAHA.115.06925) (PMID:26902494) (PMCID:PMC4789491)

Horikoshi, M. et al. (2016) Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), pp. 248-252. (doi: 10.1038/nature19806) (PMID:27680694) (PMCID:PMC5164934)

2013

Robertson, S., MacKenzie, S. M. , Alvarez-Madrazo, S., Diver, L. A., Lin, J., Stewart, P. M., Fraser, R., Connell, J. M. and Davies, E. (2013) MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. Hypertension, 62(3), pp. 572-578. (doi: 10.1161/HYPERTENSIONAHA.113.01102) (PMID:23836801)

Alvarez-Madrazo, S. et al. (2013) Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension, 61(1), pp. 232-239. (doi: 10.1161/HYPERTENSIONAHA.112.200741)

2012

McManus, F., Sands, W., Diver, L., MacKenzie, S. M. , Fraser, R., Davies, E. and Connell, J. M. (2012) APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans. Circulation Research, 111(2), pp. 212-219. (doi: 10.1161/CIRCRESAHA.111.262931)

MacKenzie, S. M. , Connell, J. M.C. and Davies, E. (2012) Non-adrenal synthesis of aldosterone: A reality check. Molecular and Cellular Endocrinology, 350(2), pp. 163-167. (doi: 10.1016/j.mce.2011.06.026)

2010

McNeilly, A. D. et al. (2010) Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice. Journal of Hepatology, 52(5), pp. 705-711. (doi: 10.1016/j.jhep.2009.10.037)

2009

Reynolds, R. M., Walker, B. R., Phillips, D. I., Dennison, E. M., Fraser, R., MacKenzie, S. M., Davies, E. and Connell, J. M. (2009) Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure. Hypertension, 53(6), pp. 932-936. (doi: 10.1161/​HYPERTENSIONAHA.109.129320)

McManus, F., MacKenzie, S.M. and Freel, E.M. (2009) Central mineralocorticoid receptors, sympathetic activity, and hypertension. Current Hypertension Reports, 11(3), pp. 224-230. (doi: 10.1007/s11906-009-0039-0)

Davies, E., MacKenzie, S. M., Freel, E. M., Alvarez-Madrazo, S., Fraser, R. and Connell, J. M.C. (2009) Altered corticosteroid biosynthesis in essential hypertension: a digenic phenomenon. Molecular and Cellular Endocrinology, 300(1-2), pp. 185-191. (doi: 10.1016/j.mce.2008.09.014)

Holloway, C.D. et al. (2009) Effects of genetic variation in the aldosterone synthase (CYP11B2) gene on enzyme function. Clinical Endocrinology, 70(3), pp. 363-371. (doi: 10.1111/j.1365-2265.2008.03383.x)

2008

Huda, S. S., MacKenzie, S. M., Sattar, N., Fraser, R., Connell, J. M. C. and Davies, E. (2008) Depot-specific steroidogenic gene transcription in human adipose tissue. Clinical Endocrinology, 69(6), pp. 848-854. (doi: 10.1111/j.1365-2265.2008.03262.x)

Connell, J. M.C., MacKenzie, S. M. , Freel, E. M., Fraser, R. and Davies, E. (2008) A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocrine Reviews, 29(2), pp. 133-154. (doi: 10.1210/er.2007-0030)

Ye, P., Kenyon, C. J., MacKenzie, S. M. , Nichol, K., Seckl, J. R., Fraser, R., Connell, J. M.C. and Davies, E. (2008) Effects of ACTH, dexamethasone, and adrenalectomy on 11 β-hydroxylase (CYP11B1) and aldosterone synthase(CYP11B2) gene expression in the rat central nervous system. Journal of Endocrinology, 196(2), pp. 305-311. (doi: 10.1677/JOE-07-0439)

MacKenzie, S. M. , Dewar, D. , Stewart, W. , Fraser, R., Connell, J. M. C. and Davies, E. (2008) The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. Journal of Endocrinology, 196(1), pp. 123-130. (doi: 10.1677/JOE-07-0427)

2007

Barr, M. et al. (2007) Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. Hypertension, 49(1), pp. 113-119. (doi: 10.1161/01.HYP.0000249904.93940.7a)

2006

MacKenzie, S. M. and Connell, J. M.C. (2006) Hypertension and the expanding role of aldosterone. Current Hypertension Reports, 8(3), pp. 255-261. (doi: 10.1007/s11906-006-0059-y) (PMID:17147925)

Barr, M., MacKenzie, S. , Wilkinson, D., Holloway, C., Friel, E., Miller, S., MacDonald, T., Fraser, R., Connell, J. and Davies, E. (2006) Functional effects of genetic variants in the 11 beta-hydroxylase (CYP11B1) gene. Clinical Endocrinology, 65, pp. 816-825. (doi: 10.1111/j.1365-2265.2006.02673.x)

2005

Ye, P. et al. (2005) The aldosterone synthase (CYP11B2) and 11 beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart. Endocrinology, 146(12), pp. 5287-5293. (doi: 10.1210/en.2005-0370) (PMID:16179417)

2004

Connell, J. M.C., Fraser, R., MacKenzie, S. M. , Friel, E. C., Ingram, M. C., Holloway, C. D. and Davies, E. (2004) The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation. Molecular and Cellular Endocrinology, 217(1-2), pp. 243-247. (doi: 10.1016/j.mce.2003.10.025) (PMID:15134824)

Kennon, B., Ingram, M., Friel, E., Anderson, N., MacKenzie, S. , Davies, E. , Shakerdi, L., Wallace, A., Fraser, R. and Connell, J. (2004) Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjects. Clinical Endocrinology, 61, pp. 174-181. (doi: 10.1111/j.1365-2265.2004.02073.x)

MacKenzie, S. , Molloy, R., O'Dwyer, P., Vella, M. and Young, I. (2004) Impact of video colonoscopy on stage and outcome of patients with symptomatic colorectal cancer. Surgical Endoscopy and Other Interventional Techniques, 18(8), pp. 1268-1271.

2003

Davies, E. and MacKenzie, S. M. (2003) Extra-adrenal production of corticosteroids. Clinical and Experimental Pharmacology and Physiology, 30(7), pp. 437-445. (doi: 10.1046/j.1440-1681.2003.03867.x) (PMID:12823256)

Connell, J., Fraser, R., MacKenzie, S. and Davies, E. (2003) Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension? Hypertension, 41, pp. 993-999. (doi: 10.1161/01.HYP.0000064344.00173.44)

Drummond, I., Galloway, D., MacKenzie, S., Molloy, R., Norrie, J., O'Dwyer, P., Vella, M. and Walker, A. (2003) Randomized clinical trial comparing consultant-led or open access investigation for large bowel symptoms. British Journal of Surgery, 90(8), pp. 941-947.

Ye, P., Kenyon, C., MacKenzie, S. , Seckl, J., Fraser, R., Connell, J. and Davies, E. (2003) Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II. Endocrinology, 144, pp. 3321-3328. (doi: 10.1210/en.2003-0109)

2002

MacKenzie, S. M. , Fraser, R., Connell, J. M.C. and Davies, E. (2002) Local renin-angiotensin systems and their interactions with extra-adrenal corticosteroid production. Journal of the Renin-Angiotensin-Aldosterone System, 3(4), pp. 214-221. (doi: 10.3317/jraas.2002.043) (PMID:12584665)

MacKenzie, S. , Lai, M., Clark, C., Fraser, R., Gomez-Sanchez, C., Seckl, J., Connell, J. and Davies, E. (2002) 11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons. Journal of Molecular Endocrinology, 29(3), pp. 319-325. (doi: 10.1677/jme.0.0290319)

2000

MacKenzie, S.M. , Clark, C.J., Fraser, R., Gomez-Sanchez, C.E., Connell, J. and Davies, E. (2000) Expression of 11 beta-hydroxylase and aldosterone synthase genes in the rat brain. Journal of Molecular Endocrinology, 24(3), pp. 321-328. (doi: 10.1677/jme.0.0240321) (PMID:10828825)

MacKenzie, S.M. , Clark, C.J., Ingram, M.C., Lai, M., Seckl, J., Gomez-Sanchez, C.E., Fraser, R., Connell, J.M.C. and Davies, E. (2000) Corticosteroid production by fetal rat hippocampal neurons. Endocrine Research, 26(4), pp. 531-535. (doi: 10.3109/07435800009048566) (PMID:11196425)

This list was generated on Tue Apr 23 21:11:19 2024 BST.
Jump to: Articles | Book Sections
Number of items: 42.

Articles

Reel, P. S. et al. (2022) Machine learning for classification of hypertension subtypes using multi-omics: a multi-centre, retrospective, data-driven study. EBioMedicine, 84, 104276. (doi: 10.1016/j.ebiom.2022.104276) (PMID:36179553) (PMCID:PMC9520210)

Moudio, S. et al. (2022) Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines. Psychopharmacology, 239(1), pp. 229-242. (doi: 10.1007/s00213-021-06040-1) (PMID:34888704) (PMCID:PMC8770450)

Armignacco, R. et al. (2022) Whole blood methylome-derived features to discriminate endocrine hypertension. Clinical Epigenetics, 14, 142. (doi: 10.1186/s13148-022-01347-y) (PMID:36329530) (PMCID:PMC9635165)

MacKenzie, S. M. , Saunders, H., van Kralingen, J. C., Robertson, S. , Riddell, A. , Zennaro, M.-C. and Davies, E. (2021) Circulating microRNAs as diagnostic markers in primary aldosteronism. Cancers, 13(21), 5312. (doi: 10.3390/cancers13215312) (PMCID:PMC8582381)

McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137(1), pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911) (PMID:29030345) (PMCID:PMC5757664)

Robertson, S., Diver, L. A., Alvarez-Madrazo, S., Livie, C., Ejaz, A., Fraser, R., Connell, J. M., MacKenzie, S. M. and Davies, E. (2017) Regulation of corticosteroidogenic genes by microRNAs. International Journal of Endocrinology, 2017, 2021903. (doi: 10.1155/2017/2021903) (PMID:28852406) (PMCID:PMC5568613)

MacKenzie, S. M. , Freel, M., Connell, J. M., Fraser, R. and Davies, E. (2017) ACTH and polymorphisms at steroidogenic loci as determinants of aldosterone secretion and blood pressure. International Journal of Molecular Sciences, 18(3), 579. (doi: 10.3390/ijms18030579) (PMID:28272372) (PMCID:PMC5372595)

Abulkassim, R., Brett, R., MacKenzie, S. M. and Bushell, T. J. (2016) Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour. Journal of Neuroimmunology, 295-96, pp. 139-147. (doi: 10.1016/j.jneuroim.2016.04.016) (PMID:27235359)

Diver, L. A. et al. (2016) Common polymorphisms at the CYP17A1 locus associate with steroid phenotype: support for blood pressure genome-wide association study signals at this locus. Hypertension, 67(4), pp. 724-732. (doi: 10.1161/HYPERTENSIONAHA.115.06925) (PMID:26902494) (PMCID:PMC4789491)

Horikoshi, M. et al. (2016) Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), pp. 248-252. (doi: 10.1038/nature19806) (PMID:27680694) (PMCID:PMC5164934)

Robertson, S., MacKenzie, S. M. , Alvarez-Madrazo, S., Diver, L. A., Lin, J., Stewart, P. M., Fraser, R., Connell, J. M. and Davies, E. (2013) MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. Hypertension, 62(3), pp. 572-578. (doi: 10.1161/HYPERTENSIONAHA.113.01102) (PMID:23836801)

Alvarez-Madrazo, S. et al. (2013) Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension, 61(1), pp. 232-239. (doi: 10.1161/HYPERTENSIONAHA.112.200741)

McManus, F., Sands, W., Diver, L., MacKenzie, S. M. , Fraser, R., Davies, E. and Connell, J. M. (2012) APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans. Circulation Research, 111(2), pp. 212-219. (doi: 10.1161/CIRCRESAHA.111.262931)

MacKenzie, S. M. , Connell, J. M.C. and Davies, E. (2012) Non-adrenal synthesis of aldosterone: A reality check. Molecular and Cellular Endocrinology, 350(2), pp. 163-167. (doi: 10.1016/j.mce.2011.06.026)

McNeilly, A. D. et al. (2010) Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice. Journal of Hepatology, 52(5), pp. 705-711. (doi: 10.1016/j.jhep.2009.10.037)

Reynolds, R. M., Walker, B. R., Phillips, D. I., Dennison, E. M., Fraser, R., MacKenzie, S. M., Davies, E. and Connell, J. M. (2009) Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure. Hypertension, 53(6), pp. 932-936. (doi: 10.1161/​HYPERTENSIONAHA.109.129320)

McManus, F., MacKenzie, S.M. and Freel, E.M. (2009) Central mineralocorticoid receptors, sympathetic activity, and hypertension. Current Hypertension Reports, 11(3), pp. 224-230. (doi: 10.1007/s11906-009-0039-0)

Davies, E., MacKenzie, S. M., Freel, E. M., Alvarez-Madrazo, S., Fraser, R. and Connell, J. M.C. (2009) Altered corticosteroid biosynthesis in essential hypertension: a digenic phenomenon. Molecular and Cellular Endocrinology, 300(1-2), pp. 185-191. (doi: 10.1016/j.mce.2008.09.014)

Holloway, C.D. et al. (2009) Effects of genetic variation in the aldosterone synthase (CYP11B2) gene on enzyme function. Clinical Endocrinology, 70(3), pp. 363-371. (doi: 10.1111/j.1365-2265.2008.03383.x)

Huda, S. S., MacKenzie, S. M., Sattar, N., Fraser, R., Connell, J. M. C. and Davies, E. (2008) Depot-specific steroidogenic gene transcription in human adipose tissue. Clinical Endocrinology, 69(6), pp. 848-854. (doi: 10.1111/j.1365-2265.2008.03262.x)

Connell, J. M.C., MacKenzie, S. M. , Freel, E. M., Fraser, R. and Davies, E. (2008) A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocrine Reviews, 29(2), pp. 133-154. (doi: 10.1210/er.2007-0030)

Ye, P., Kenyon, C. J., MacKenzie, S. M. , Nichol, K., Seckl, J. R., Fraser, R., Connell, J. M.C. and Davies, E. (2008) Effects of ACTH, dexamethasone, and adrenalectomy on 11 β-hydroxylase (CYP11B1) and aldosterone synthase(CYP11B2) gene expression in the rat central nervous system. Journal of Endocrinology, 196(2), pp. 305-311. (doi: 10.1677/JOE-07-0439)

MacKenzie, S. M. , Dewar, D. , Stewart, W. , Fraser, R., Connell, J. M. C. and Davies, E. (2008) The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. Journal of Endocrinology, 196(1), pp. 123-130. (doi: 10.1677/JOE-07-0427)

Barr, M. et al. (2007) Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. Hypertension, 49(1), pp. 113-119. (doi: 10.1161/01.HYP.0000249904.93940.7a)

MacKenzie, S. M. and Connell, J. M.C. (2006) Hypertension and the expanding role of aldosterone. Current Hypertension Reports, 8(3), pp. 255-261. (doi: 10.1007/s11906-006-0059-y) (PMID:17147925)

Barr, M., MacKenzie, S. , Wilkinson, D., Holloway, C., Friel, E., Miller, S., MacDonald, T., Fraser, R., Connell, J. and Davies, E. (2006) Functional effects of genetic variants in the 11 beta-hydroxylase (CYP11B1) gene. Clinical Endocrinology, 65, pp. 816-825. (doi: 10.1111/j.1365-2265.2006.02673.x)

Ye, P. et al. (2005) The aldosterone synthase (CYP11B2) and 11 beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart. Endocrinology, 146(12), pp. 5287-5293. (doi: 10.1210/en.2005-0370) (PMID:16179417)

Connell, J. M.C., Fraser, R., MacKenzie, S. M. , Friel, E. C., Ingram, M. C., Holloway, C. D. and Davies, E. (2004) The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation. Molecular and Cellular Endocrinology, 217(1-2), pp. 243-247. (doi: 10.1016/j.mce.2003.10.025) (PMID:15134824)

Kennon, B., Ingram, M., Friel, E., Anderson, N., MacKenzie, S. , Davies, E. , Shakerdi, L., Wallace, A., Fraser, R. and Connell, J. (2004) Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjects. Clinical Endocrinology, 61, pp. 174-181. (doi: 10.1111/j.1365-2265.2004.02073.x)

MacKenzie, S. , Molloy, R., O'Dwyer, P., Vella, M. and Young, I. (2004) Impact of video colonoscopy on stage and outcome of patients with symptomatic colorectal cancer. Surgical Endoscopy and Other Interventional Techniques, 18(8), pp. 1268-1271.

Davies, E. and MacKenzie, S. M. (2003) Extra-adrenal production of corticosteroids. Clinical and Experimental Pharmacology and Physiology, 30(7), pp. 437-445. (doi: 10.1046/j.1440-1681.2003.03867.x) (PMID:12823256)

Connell, J., Fraser, R., MacKenzie, S. and Davies, E. (2003) Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension? Hypertension, 41, pp. 993-999. (doi: 10.1161/01.HYP.0000064344.00173.44)

Drummond, I., Galloway, D., MacKenzie, S., Molloy, R., Norrie, J., O'Dwyer, P., Vella, M. and Walker, A. (2003) Randomized clinical trial comparing consultant-led or open access investigation for large bowel symptoms. British Journal of Surgery, 90(8), pp. 941-947.

Ye, P., Kenyon, C., MacKenzie, S. , Seckl, J., Fraser, R., Connell, J. and Davies, E. (2003) Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II. Endocrinology, 144, pp. 3321-3328. (doi: 10.1210/en.2003-0109)

MacKenzie, S. M. , Fraser, R., Connell, J. M.C. and Davies, E. (2002) Local renin-angiotensin systems and their interactions with extra-adrenal corticosteroid production. Journal of the Renin-Angiotensin-Aldosterone System, 3(4), pp. 214-221. (doi: 10.3317/jraas.2002.043) (PMID:12584665)

MacKenzie, S. , Lai, M., Clark, C., Fraser, R., Gomez-Sanchez, C., Seckl, J., Connell, J. and Davies, E. (2002) 11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons. Journal of Molecular Endocrinology, 29(3), pp. 319-325. (doi: 10.1677/jme.0.0290319)

MacKenzie, S.M. , Clark, C.J., Fraser, R., Gomez-Sanchez, C.E., Connell, J. and Davies, E. (2000) Expression of 11 beta-hydroxylase and aldosterone synthase genes in the rat brain. Journal of Molecular Endocrinology, 24(3), pp. 321-328. (doi: 10.1677/jme.0.0240321) (PMID:10828825)

MacKenzie, S.M. , Clark, C.J., Ingram, M.C., Lai, M., Seckl, J., Gomez-Sanchez, C.E., Fraser, R., Connell, J.M.C. and Davies, E. (2000) Corticosteroid production by fetal rat hippocampal neurons. Endocrine Research, 26(4), pp. 531-535. (doi: 10.3109/07435800009048566) (PMID:11196425)

Book Sections

MacKenzie, S. M. , Birch, L. A., Lamprou, S., Rezvanisanijouybari, P., Fayad, M., Zennaro, M.-C. and Davies, E. (2023) MicroRNAs in aldosterone production and action. In: Vitamins and Hormones. Series: Vitamins and hormones. Elsevier. (doi: 10.1016/bs.vh.2023.07.001) (In Press)

MacKenzie, S. M. , Nguyen Dinh Cat, A., van Kralingen, J. and Davies, E. (2019) Aldosterone. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 103-115. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_10)

MacKenzie, S. M. , Van Kralingen, J. C. and Davies, E. (2019) Regulation of aldosterone secretion. In: Litwack, G. (ed.) Aldosterone. Series: Vitamins and Hormones (109). Elsevier, pp. 241-263. ISBN 9780128177822 (doi: 10.1016/bs.vh.2018.07.001)

MacKenzie, S. M. , Davies, E. and Alvarez-Madrazo, S. (2017) Analysis of the aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) genes. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 139-150. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_11)

This list was generated on Tue Apr 23 21:11:19 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • HT-Advance
    Innovate EU Guarantee
    2022 - 2028
     
  • ENSAT-HF
    European Commission
    2015 - 2020
     
  • Understanding the genetic regulation of adrenal steroid hormones in cardiovascular disease - Developing a stratified approach to cardiovascular care
    Chief Scientist Office
    2014 - 2016
     
  • Identification and characterization of CYP11B1 alternative isoforms in human adrenals and H295R cells.
    Tenovus Scotland
    2011 - 2013
     
  • Regulation of aldosterone synthase (CYP11B2) and 11b-Hydroxylase gene expression by novel micro RNAs
    British Heart Foundation
    2010 - 2013
     
  • Research Councils UK academic fellowships - adrenal and extra-adrenal production of corticosteroids
    Engineering and Physical Sciences Research Council
    2006 - 2011
     
  • Functional analysis of polymorphisms/mutations in steroidogenic genes and their implications for human cardiovascular homeostasis
    British Heart Foundation
    2005 - 2007
     
  • The role of corticosteroids in obesity
    Hypertension Trust
    2004 - 2006
     
  • Quantification of 11 beta-hydroxylase (CYP11B1) gene expression in adipose tissue from normal and obese human subjects
    Tenovus Scotland
    2004 - 2005
     
  • Expression of 11 beta-hydroxylase and aldosterone synthase in the human central nervous system
    North Glasgow University Hospitals NHS Trust
    2003 - 2005
     
  • Identification and analysis of mutations in steriodogenic genes and their functional implications of human cardivacular homestasis
    British Heart Foundation
    2003 - 2005
     

Supervision

Teaching

I hold a Postgraduate Certificate in Academic Practice (PGCAP) and became a Fellow of the Higher Education Academy in 2008.

I currently deliver lectures for the MSc (Med Sci) Clinical Pharmacology course and also supervise laboratory-based and data analysis research projects for students from this and other postgraduate courses, including MSc Cardiovascular Sciences, in addition to Honours Life Science students. I also contribute sessions on Hypertension to the Molecular Basis of Cardiometabolic Disease course for Life Science Honours students. On the undergraduate Medical School course, I contribute to the Student Selected Component Course on Research Methods and previously facilitated Problem-Based Learning (PBL) sessions in Years 1 and 2. I am also a longstanding Adviser of Studies for undergraduate Life Science students.

Additional information

Research Fellowship

  • 2005 - 2010: Research Councils UK Academic Fellowship
  • 2004 - 2006: Hypertension Trust Research Fellow

staff profile