Institute of Cardiovascular and Medical Sciences

Dr Scott Mackenzie

  • Lecturer (Institute of Cardiovascular and Medical Sciences)

telephone: 01413302669
email: Scott.MacKenzie@glasgow.ac.uk


Our group’s core research investigates the production of the steroid hormones aldosterone and cortisol by the cortex of the adrenal gland. In particular, we wish to understand how genetic variation between individuals influences the regulation of these steroids’ production and how this results in high blood pressure. To this end, I have contributed to several large-scale genetic studies involving our main genes of interest, aldosterone synthase and 11β-hydroxylase. I am currently investigating whether polymorphisms in the 11β-hydroxylase gene result in its reduced expression.
As well as contributing to our group’s core studies of adrenocortical steroid production, many of my studies have examined the emerging area of extra-adrenal steroidogenesis, whereby tissues such as the brain and adipose tissue appear capable of producing low levels of aldosterone and cortisol. I have detected the aldosterone synthase and 11β-hydroxylase enzymes within brain tissue and demonstrated that their genes can be regulated within the brain independently of the adrenal gland. Current studies are investigating a link between cortisol production within the brain and Alzheimer’s disease. Other ongoing research includes the study of these genes’ production within heart tissue and fat tissue, in an attempt to better understand the processes underlying heart disease and obesity.
I have productive research projects with a number of national and international collaborators, including Dr Trevor Bushell at Strathclyde University, Professor Jonathan Seckl at Edinburgh University and Professor Celso Gomez-Sanchez at the University of Mississippi.

Jump to: 2012 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2000
Number of items: 23.

2012

MacKenzie, S.M., Connell, J.M.C. , and Davies, E. (2012) Non-adrenal synthesis of aldosterone: A reality check. Molecular and Cellular Endocrinology, 350 (2). pp. 163-167. ISSN 0303-7207 (doi:10.1016/j.mce.2011.06.026)

2009

Davies, E., Davies, E. , MacKenzie, S.M. , MacKenzie, S. , Freel, M. , Alvarez-Madrazo, S., Fraser, R. , and Connell, J. (2009) Altered corticosteroid biosynthesis in essential hypertension: A digenic phenomenon. Molecular and Cellular Endocrinology, 300 (1-2). pp. 185-191. ISSN 0303-7207 (doi:10.1016/j.mce.2008.09.014)

Holloway, C.D. et al. (2009) Effects of genetic variation in the aldosterone synthase (CYP11B2) gene on enzyme function. Clinical Endocrinology, 70 (3). pp. 363-371. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2008.03383.x)

McManus, F, MacKenzie, SM , MacKenzie, S , and Freel, M. (2009) Central mineralocorticoid receptors, sympathetic activity, and hypertension. Current Hypertension Reports, 11 (3). pp. 224-230.

Reynolds, R.M., Walker, B.R., Phillips, D.I., Dennison, E.M., , S.M. , Davies, E. , and Connell, J.M. (2009) Programming of hypertension associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure. Hypertension, 53 (6). pp. 932-936. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.109.129320)

2008

Connell, J, MacKenzie, SM , Freel, EM , Fraser, R , and Davies, E (2008) A lifetime of aldosterone excess: Long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocrine Reviews, 29 (2). pp. 133-154. ISSN 0163-769X (doi:10.1210/er.2007-0030)

MacKenzie, S.M., Dewar, D. , Stewart, W. , Fraser, R. , Connell, J. , and Davies, E. (2008) The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. Journal of Endocrinology, 196 (1). pp. 123-130. ISSN 0022-0795 (doi:10.1677/JOE-07-0427)

MacKenzie, S., MacKenzie, S.M. , Huda, S.S. , Sattar, N.A. , Fraser, R. , Connell, J. , Davies, E. , and Davies, E. (2008) Depot-specific steroidogenic gene transcription in human adipose tissue. Clinical Endocrinology, 69 (6). pp. 848-854. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2008.03262.x)

Ye, P., Kenyon, C.I., MacKenzie, S.M. , Nichol, K., Seckl, J.R., Fraser, R. , Connell, J.M.C. , and Davies, E. (2008) Effects of ACTH, dexamethasone, and adrenalectomy on 11 β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system. Journal of Endocrinology, 196 (2). pp. 305-311. ISSN 0022-0795 (doi:10.1677/JOE-07-0439)

2007

Barr, M et al. (2007) Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. Hypertension, 49 . pp. 113-119. (doi:10.1161/01.HYP.0000249904.93940.7a)

2006

Barr, M, MacKenzie, SM , Wilkinson, DM, Holloway, CD, Friel, EC, Miller, S, MacDonald, T, Fraser, R, Connell, JMC , and Davies, E (2006) Functional effects of genetic variants in the 11 beta-hydroxylase (CYP11B1) gene. Clinical Endocrinology, 65 . pp. 816-825. (doi:10.1111/j.1365-2265.2006.02673.x)

MacKenzie, SA, and Connell, JMC (2006) Hypertension and the expanding role of aldosterone. Current Hypertension Reports, 8 . pp. 255-261.

2005

Ye, P et al. (2005) The aldosterone synthase (CYP11B2) and 11 beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart. Endocrinology, 146 (12). pp. 5287-5293.

2004

Connell, J, Fraser, R, MacKenzie, SM , Friel, EC, Ingram, MC, Holloway, CD, and Davies, E (2004) The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation. Molecular and Cellular Endocrinology, 217 (01-Feb). pp. 243-247.

Kennon, B, Ingram, MC, Friel, EC, Anderson, NH, MacKenzie, SM , Davies, E , Shakerdi, L, Wallace, AM, Fraser, R, and Connell, JMC (2004) Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjects. Clinical Endocrinology, 61 . pp. 174-181. (doi:10.1111/j.1365-2265.2004.02073.x)

MacKenzie, S, Molloy, RG, O'Dwyer, PJ , Vella, M, and Young, IE (2004) Impact of video colonoscopy on stage and outcome of patients with symptomatic colorectal cancer. Surgical Endoscopy and Other Interventional Techniques, 18 (8). pp. 1268-1271.

2003

Connell, JMC, Fraser, R, MacKenzie, S , and Davies, E (2003) Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension? Hypertension, 41 . pp. 993-999. (doi:10.1161/01.HYP.0000064344.00173.44)

Davies, E, and MacKenzie, SM (2003) Extra-adrenal production of corticosteroids. Clinical and Experimental Pharmacology and Physiology, 30 . pp. 437-445.

Drummond, I, Galloway, DJ, MacKenzie, S , Molloy, R, Norrie, J, O'Dwyer, PJ , Vella, M, and Walker, A (2003) Randomized clinical trial comparing consultant-led or open access investigation for large bowel symptoms. British Journal of Surgery, 90 (8). pp. 941-947.

Ye, P, Kenyon, CJ, MacKenzie, SM , Seckl, JR, Fraser, R, Connell, JMC , and Davies, E (2003) Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II. Endocrinology, 144 . pp. 3321-3328. (doi:10.1210/en.2003-0109)

2002

MacKenzie, SM, Fraser, R, Connell, JMC , and Davies, E (2002) Local renin-angiotensin systems and their interactions with extra-adrenal corticosteroid production. Journal of the Renin-angiotensin-aldosterone System, 3 . pp. 214-221.

MacKenzie, SM, Lai, M, Clark, CJ, Fraser, R, Gomez-Sanchez, CE, Seckl, J, Connell, J , and Davies, E (2002) 11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons. Journal of Molecular Endocrinology, 29 (3). pp. 319-325. (doi:10.1677/jme.0.0290319)

2000

MacKenzie, SM, Clark, CJ, Ingram, MC, Lai, M, Seckl, J, Gomez-Sanchez, CE, Fraser, R, Connell, JMC , and Davies, E (2000) Corticosteroid production by fetal rat hippocampal neurons. Endocrine Research, 26 (4). pp. 531-535.

This list was generated on Sat May 26 14:14:52 2012 BST.
  • Identification and characterization of CYP11B1 alternative isoforms in human adrenals and H295R cells.
    Tenovus-Scotland
    2011 - 2013
     
  • Regulation of aldosterone synthase (CYP11B2) and 11b-Hydroxylase gene expression by novel micro RNAs
    British Heart Foundation
    2010 - 2013
     
  • Research Councils UK academic fellowships - adrenal and extra-adrenal production of corticosteroids
    EPSRC
    2006 - 2011
     
  • Functional analysis of polymorphisms/mutations in steroidogenic genes and their implications for human cardiovascular homeostasis
    British Heart Foundation
    2005 - 2007
     
  • The role of corticosteroids in obesity
    Hypertension Trust
    2004 - 2006
     
  • Quantification of 11 beta-hydroxylase (CYP11B1) gene expression in adipose tissue from normal and obese human subjects
    Tenovus-Scotland
    2004 - 2005
     
  • Expression of 11 beta-hydroxylase and aldosterone synthase in the human central nervous system
    North Glasgow University Hospitals NHS Trust
    2003 - 2005
     
  • Identification and analysis of mutations in steriodogenic genes and their functional implications of human cardivacular homestasis
    British Heart Foundation
    2003 - 2005
     

Research Fellowship

  • 2005 - 2010: Research Councils UK Academic Fellowship
  • 2004 - 2006: Hypertension Trust Research Fellow