Professor Rhian Touyz

  • Director of Research Institute/Professor (Institute of Cardiovascular and Medical Sciences)
  • Associate (School of Medicine)

telephone: 0141 330 7775
email: Rhian.Touyz@glasgow.ac.uk

Personal assistant: Mrs Margaret Kinninmont
telephone: 01413307774
email: Margaret.Kinninmont@glasgow.ac.uk

Research interests

 

Professor Rhian Touyz, MBBCh, MSc(Med), PhD, is the Director of the Institute of Cardiovascular and Medical Sciences (ICAMS), University of Glasgow. She is the British Heart Foundation(BHF) Chair of Cardiovascular Medicine and Director of the ICAMS BHF Award of Excellence.  She was the Canada Research Chair in Hypertension and Professor of Medicine at the Kidney Research Centre, Ottawa Hospital Research Institute (OHRI)/Univ of Ottawa. Prof Touyz received her BSc(Hons) (1980), MBBCh (1984), MSc (1986) and PhD (1992) from the University of the Witwatersrand, Johannesburg, South Africa. She completed a post-doctoral fellowship (1992-1996) at the Clinical Research Institute of Montreal.

She has received numerous academic and research awards from the American Society of Hypertension, the Canadian Society of Hypertension, the Quebec Society of Hypertension, the American Physiological Society and the American Heart Association (AHA).  In particular, she is the recipient of the Dahl Award of the AHA, the Distinguished Lecture Award,  Mannitoba Institute of Cardiovascular Sciences, and the Distinguished Service award from Hypertension Canada. She is the 2012 Robert M. Berne Distinguished Lecturer of the American Physiological Society.

Prof Touyz co-chaired the Recommendations Task Force of the Canadian Hypertension Education Program (CHEP), responsible for annual clinical hypertension guidelines, she is on the Executive of the International Society of Hypertension and she is the past President of the Canadian Hypertension Society. She Chaired the grant review panel of the Heart and Stroke Foundation of Canada and the Canadian Institutes of Health Research (CIHR) and is a member of the Microcirculation and Hypertension Study section of the National Institutes of Health (NIH), USA. She is the immediate past Chair of the Council for High Blood Pressure Research of the American Heart Association. She is funded by grants from the Heart and Stroke Foundation of Canada, the CIHR, the Kidney foundation of Canada/Pfizer, the Juvenile Diabetes Research Foundation and the British Heart Foundation. She is the Editor-In-Chief of Clinical Science and Deputy Editor of Hypertension.  She is the Associate Editor of Pharmacological Reviews.

Prof Touyz has trained over 40 graduate and post-graduate students and has published over 290 original papers and many review articles. Her laboratory is very trainee-oriented. Her main focus of research relates to molecular, cellular and vascular mechanisms of hypertension. Prof Touyz is a clinician-scientist and her areas of research includes clinical and experimental hypertension, signal transduction, oxidative stress, ion transport, vascular biology, adipose tissue biology and diabetes. She has a particular interest in translational and clinical research.

Research:

Member:

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Characterising vascular pathophysiology in CADASIL (cerebral autosomal dominant arteriopathy with subacute infarcts and leukoencephalopathy) by evaluation of gluteal resistance vessels
    The Stroke Association
    2013 - 2016
     
  • Regulation of the renin angiotension aldosterone system in adipose tissue by AMP-activated protein kinase
    Diabetes UK
    2013 - 2016
     
  • Sessional CRF Support
    NHS Greater Glasgow and CLyde
    2013 - 2014
     
  • Vascular Noxs as therapeutic targets and biomarkers in hypertension
    British Heart Foundation
    2013 - 2018
     
  • Vascular Noxs as therapeutic targets and biomarkers in hypertension
    British Heart Foundation
    2013 - 2018
     
  • Vascular Noxs as therapeutic targets and biomarkers in hypertension
    British Heart Foundation
    2013 - 2018
     
  • Vascular Noxs as therapeutic targets and biomarkers in hypertension
    British Heart Foundation
    2013
     
  • RADOX: RADical reduction of OXidative stress in cardiovascular diseases
    European Commission
    2013 - 2016
     
  • Vascular Noxs as therapeutic targets and biomarkers in hypertension
    British Heart Foundation
    2012 - 2017
     

Publications

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Number of items: 336.

2014

Beattie, C. J., Fulton, R. L., Higgins, P., Padmanabhan, S., McCallum, L., Walters, M. R., Dominiczak, A. F., Touyz, R. M., and Dawson, J. (2014) Allopurinol initiation and change in blood pressure in older adults with hypertension. Hypertension, 64(5). pp. 1102-1107. (doi:10.1161/HYPERTENSIONAHA.114.03953)

Dipchand, A.I., White, M., Manlhiot, C., Pollock-BarZiv, S., Allain-Rooney, T., West, L., He, Y., and Touyz, R.M. (2014) Myocyte growth, repair, and oxidative stress following pediatric heart transplantation. Pediatric Transplantation, 18(7). pp. 764-770. (doi:10.1111/petr.12337)

Touyz, R. M. (2014) Linking LOX-1 and arginase II through mitochondria: a novel paradigm in endothelial dysfunction. Circulation Research, 115(4). pp. 412-414. (doi:10.1161/CIRCRESAHA.114.304550)

Jha, J. C. et al. (2014) Genetic targeting or pharmacologic inhibition of NADPH oxidase Nox4 provides renoprotection in long-term diabetic nephropathy. Journal of the American Society of Nephrology, 25(6). pp. 1237-1254. (doi:10.1681/ASN.2013070810)

Wilkinson-Berka, J. L. et al. (2014) NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy. Antioxidants and Redox Signaling, 20(17). pp. 2726-2740. (doi:10.1089/ars.2013.5357)

Montezano, A. C., and Touyz, R. M. (2014) Mammalian target of Rapamycin: a novel pathway in vascular calcification. Canadian Journal of Cardiology, 30(5). pp. 482-484. (doi:10.1016/j.cjca.2014.03.001)

Small, H. Y., Montezano, A. C., Rios, F. J., Savoia, C., and Touyz, R. M. (2014) Hypertension due to antiangiogenic cancer therapy with vascular endothelial growth factor inhibitors: understanding and managing a new syndrome. Canadian Journal of Cardiology, 30(5). pp. 534-543. (doi:10.1016/j.cjca.2014.02.011)

Montezano, A. C., Nguyen Dinh Cat, A., Rios, F. J., and Touyz, R. M. (2014) Angiotensin II and vascular injury. Current Hypertension Reports, 16(6). p. 431. (doi:10.1007/s11906-014-0431-2)

Marco, E. et al. (2014) Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune–inflammatory responses in diabetic Apoe −/− mice. Diabetologia, 57(3). pp. 633-642. (doi:10.1007/s00125-013-3118-3)

Campbell, N. et al. (2014) The World Hypertension League and International Society of Hypertension call on governments, nongovernmental organizations, and the food industry to work to reduce dietary sodium. Journal of Clinical Hypertension, 16(2). pp. 99-100. (doi:10.1111/jch.12245)

Campbell, N.R.C. et al. (2014) The International Society of Hypertension and World Hypertension League call on governments, nongovernmental organizations and the food industry to work to reduce dietary sodium. Journal of Hypertension, 32(2). pp. 446-447. (doi:10.1097/HJH.0000000000000079)

Montezano, A. C., and Touyz, R. M. (2014) Reactive oxygen species, vascular noxs, and hypertension: focus on translational and clinical research. Antioxidants and Redox Signaling, 20(1). pp. 164-182. (doi:10.1089/ars.2013.5302)

Bruder-Nascimento, T., Chinnasamy, P., Riascos-Bernal, D.F., Cau, S.B., Callera, G.E., Touyz, R.M., Tostes, R.C., and Sibinga, N.E.S. (2014) Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation. Journal of Molecular and Cellular Cardiology, 66. pp. 18-26. (doi:10.1016/j.yjmcc.2013.10.013)

Weber, M.A. et al. (2014) Clinical practice guidelines for the management of hypertension in the community a statement by the American society of hypertension and the international society of hypertension. Journal of Hypertension, 32(1). pp. 3-15. (doi:10.1097/HJH.0000000000000065)

Jennings, G. L.R., and Touyz, R. M. (2014) Response to European Society of Hypertension and European Society of Cardiology Guidelines and the muted enthusiasm for home blood pressure monitoring. Hypertension, 63(2). e6. (doi:10.1161/HYPERTENSIONAHA.113.02423)

Zimmerman, D. L., Ruzicka, M., Hebert, P., Fergusson, D., Touyz, R. M., and Burns, K. D. (2014) Short daily versus conventional hemodialysis for hypertensive patients: a randomized cross-over study. PLoS ONE, 9(5). e97135. (doi:10.1371/journal.pone.0097135)

2013

Thibodeau, J., Nasrallah, R., Carter, A., He, Y., Touyz, R., Hébert, R.L., and Kennedy, C.R.J. (2013) PTGER1 deletion attenuates renal injury in diabetic mouse models. American Journal of Pathology, 183(6). pp. 1789-1802. (doi:10.1016/j.ajpath.2013.08.022)

White, M. et al. (2013) Cardiac signaling molecules and plasma biomarkers after cardiac transplantation: impact of tacrolimus versus cyclosporine. Journal of Heart and Lung Transplantation, 32(12). pp. 1222-1232. (doi:10.1016/j.healun.2013.09.010)

Yogi, A. et al. (2013) Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain. Cellular Signalling, 25(11). pp. 2163-2175. (doi:10.1016/j.cellsig.2013.07.002)

Sedeek, M., Nasrallah, R., Touyz, R.M., and Hebert, R.L. (2013) NADPH oxidases, reactive oxygen species, and the kidney: friend and foe. Journal of the American Society of Nephrology, 24(10). pp. 1512-1518. (doi:10.1681/ASN.2012111112)

Nguyen Dinh Cat, A., Montezano, A.C., Burger, D., and Touyz, R.M. (2013) Angiotensin II, NADPH oxidase, and redox signaling in the vasculature. Antioxidants and Redox Signaling, 19(10). pp. 1110-1120. (doi:10.1089/ars.2012.4641)

Gray, S.P. et al. (2013) NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation, 127(18). pp. 1888-1902. (doi:10.1161/CIRCULATIONAHA.112.132159)

Chalmers, J., Arima, H., Harrap, S., Touyz, R.M., and Park, J.B. (2013) Global survey of current practice in management of hypertension as reported by societies affiliated with the international society of hypertension. Journal of Hypertension, 31(5). pp. 1043-1048. (doi:10.1097/HJH.0b013e32835f7eef)

Touyz, R.M. (2013) Combination antihypertensive treatment with aliskiren and blockers of the renin-angiotensin system—reassurance but with a note of caution. Canadian Journal of Cardiology, 29(5). pp. 521-523. (doi:10.1016/j.cjca.2013.02.020)

Der Sarkissian, S., Tea, B., Touyz, R.M., deBlois, D., and Hale, T.M. (2013) Role of angiotensin II type 2 receptor during regression of cardiac hypertrophy in spontaneously hypertensive rats. Journal of the American Society of Hypertension, 7(2). pp. 118-127. (doi:10.1016/j.jash.2013.01.002)

Antunes, T.T., Callera, C., and Touyz, R.M. (2013) Vascular biology of magnesium: implications in cardiovascular disease. In: Watson, R.R., Preedy, V.R. and Zibadi, S. (eds.) Magnesium in Human Health and Disease. Series: Nutrition and health. Humana Press. ISBN 9781627030434

Burger, D., Schock, S., Thompson, C.S., Montezano, A.C., Hakim, A.M., and Touyz, R.M. (2013) Microparticles: biomarkers and beyond. Clinical Science, 124(7). pp. 423-441. (doi:10.1042/CS20120309)

Jennings, G.L.R., and Touyz, R.M. (2013) Hypertension guidelines: more challenges highlighted by Europe. Hypertension, 62(4). pp. 660-665. (doi:10.1161/HYPERTENSIONAHA.113.02034)

Montezano, A.C., Antunes, T.T., Callera, G.E., and Touyz, R.M. (2013) Magnesium and vessels. In: Kreitsinger, R., Permyakov, E. and Uversky, V. (eds.) Encyclopedia of Metalloproteins. Springer. ISBN 9781461415329

Montezano, A.C., and Touyz, R.M. (2013) Mechanosensitive regulation of cortactin by p47phox: a new paradigm in cytoskeletal remodeling. Circulation Research, 112(12). pp. 1522-1525. (doi:10.1161/CIRCRESAHA.113.301495)

Sedeek, M. et al. (2013) Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes. Clinical Science, 124(3). pp. 191-202. (doi:10.1042/CS20120330)

Touyz, R.M., and Montezano, A.C. (2013) Vascular function. In: Rosendorff , C. (ed.) Essential Cardiology: Principles and Practice. Springer. ISBN 9781461467045

2012

Sedeek, M. et al. (2012) Oxidative stress, Nox isoforms and complications of diabetes—potential targets for novel therapies. Journal of Cardiovascular Translational Research, 5(4). pp. 509-518. (doi:10.1007/s12265-012-9387-2)

Montezano, A.C., and Touyz, R.M. (2012) Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies. Annals of Medicine, 44(S1). S2-S16. (doi:10.3109/07853890.2011.653393)

Montezano, A.C., and Touyz, R.M. (2012) Molecular mechanisms of hypertension—reactive oxygen species and antioxidants: a basic science update for the clinician. Canadian Journal of Cardiology, 28(3). pp. 288-295. (doi:10.1016/j.cjca.2012.01.017)

Burger, D., and Touyz, R.M. (2012) Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells. Journal of the American Society of Hypertension , 6(2). pp. 85-99. (doi:10.1016/j.jash.2011.11.003)

Briones, A.M. et al. (2012) Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction. Hypertension, 59(9). pp. 1069-1078. (doi:10.1161/HYPERTENSIONAHA.111.190223)

Burger, D., Gutsol, A., Carter, A., Allan, D.S., Touyz, R.M., and Burns, K.D. (2012) Human cord blood CD133+ cells exacerbate ischemic acute kidney injury in mice. Nephrology, Dialysis, Transplantation, 27(10). pp. 3781-3789. (doi:10.1093/ndt/gfs110)

Burger, D., Kwart, D.G., Montezano, A.C., Read, N.C., Kennedy, C.R.J., Thompson, C.S., and Touyz, R.M. (2012) Microparticles induce cell cycle arrest through redox-sensitive processes in endothelial cells: implications in vascular senescence. Journal of the American Heart Association, 1(3). e001842-e001842. (doi:10.1161/JAHA.112.001842)

Burger, D., Veerabhadrappa, P., Charchar, F., Tomaszewski, M., Harrap, S., Carlberg, B., and Touyz, R.M. (2012) Report of the first International Society of Hypertension (ISH) Trainee/New Investigator Symposium: A Global Hypertension Initiative. Journal of Hypertension, 30(3). pp. 631-632. (doi:10.1097/HJH.0b013e32834f8267)

Chignalia, A.Z. et al. (2012) Testosterone induces vascular smooth muscle cell migration by NADPH oxidase and c-Src-dependent pathways. Hypertension, 59(6). pp. 1263-1271. (doi:10.1161/HYPERTENSIONAHA.111.180620)

Montezano, A.C., and Touyz, R.M. (2012) Reactive Oxygen Species and the Cardiovascular System. Series: Integrated systems physiology. Morgan & Claypool. ISBN 9781615043620

Montezano, A.C., and Touyz, R.M. (2012) Reactive oxygen species and endothelial function - role of nitric oxide synthase uncoupling and nox family Nicotinamide Adenine Dinucleotide Phosphate oxidases. Basic and Clinical Pharmacology and Toxicology, 110(1). pp. 87-94. (doi:10.1111/j.1742-7843.2011.00785.x)

Paravicini, T.M., Montezano, A.C., Yusuf, H., and Touyz, R.M. (2012) Activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: influence of hypertension and angiotensin II. Journal of the American Society of Hypertension , 6(3). pp. 169-178. (doi:10.1016/j.jash.2012.01.002)

Rocha, J.T., Hipolito, U.V., Callera, G.E., Yogi, A., Filho, A., Bendhack, L.M., Touyz, R.M., and Tirapelli, C.R. (2012) Ethanol induces vascular relaxation via redox-sensitive and nitric oxide-dependent pathways. Vascular Pharmacology, 56(1-2). pp. 74-83. (doi:10.1016/j.vph.2011.11.006)

Touyz, R.M. (2012) New insights into mechanisms of hypertension. Current Opinion in Nephrology and Hypertension, 21(2). pp. 119-121. (doi:10.1097/MNH.0b013e328350a50f)

Touyz, R.M., and Burger, D. (2012) Biomarkers in hypertension. In: Berbari, A.J. and Mancia, G. (eds.) Special issues in Hypertension. Springer, pp. 237-246. ISBN 9788847026001

Touyz, R.M., and Montezano, A.C. (2012) Vascular Nox4: a multifarious NADPH oxidase. Circulation Research, 110(9). pp. 1159-1161. (doi:10.1161/CIRCRESAHA.112.269068)

Touyz, R.M., and Schiffrin, E.L. (2012) Arterial hypertension. In: Hill, J. and Olson, E.N. (eds.) Muscle: Fundamental Biology and Mechanisms of Disease. Pt. IV. Smooth Muscle. Elsevier, pp. 1301-1311. ISBN 9780123815101

Veerabhadrappa, P., Burger, D., Charchar, F., Tomaszewski, M., Carlberg, B., Harrap, S., and Touyz, R.M. (2012) Council for High Blood Pressure Research/InterAmerican Society of Hypertension/International Society of Hypertension: First New Investigators Symposium at the High Blood Pressure Research 2011 Scientific Sessions. Hypertension, 59(2). pp. 382-383. (doi:10.1161/HYPERTENSIONAHA.111.185421)

White, M., Montezano, A.C., and Touyz, R.M. (2012) Angiotensin II signalling and calcineurin in cardiac fibroblasts: differential effects of calcineurin inhibitors FK506 and cyclosporine A. Therapeutic Advances in Cardiovascular Disease, 6(1). pp. 5-14. (doi:10.1177/1753944711432901)

Yogi, A., Callera, G.E., Mecawi, A.S., Batalhão, M.E., Carnio, E.C., Antunes-Rodrigues, J., Queiroz, R.H., Touyz, R.M., and Tirapelli, C.R. (2012) Acute ethanol intake induces superoxide anion generation and mitogen-activated protein kinase phosphorylation in rat aorta: A role for angiotensin type 1 receptor. Toxicology and Applied Pharmacology, 264(3). pp. 470-478. (doi:10.1016/j.taap.2012.08.029)

2011

Al Ghouleh, I. et al. (2011) Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling. Free Radical Biology and Medicine, 51(7). pp. 1271-1288. (doi:10.1016/j.freeradbiomed.2011.06.011)

Chung, Y. et al. (2011) Vascular progenitor recruitment in critically ill patients with acute kidney injury. Clinical and Investigative Medicine, 34(5). E304.

Nguyen Dinh Cat, A., and Touyz, R.M. (2011) A new look at the renin–angiotensin system--focusing on the vascular system. Peptides, 32(10). pp. 2141-2150. (doi:10.1016/j.peptides.2011.09.010)

Cascino, T., Csanyi, G., Al Ghouleh, I., Montezano, A.C., Touyz, R.M., Haurani, M.J., and Pagano, P.J. (2011) Adventitia-derived hydrogen peroxide impairs relaxation of the rat carotid artery via smooth muscle cell p38 mitogen-activated protein kinase. Antioxidants and Redox Signaling, 15(6). pp. 1507-1515. (doi:10.1089/ars.2010.3631)

Touyz, R.M., and Grassi, G. (2011) Renal biomarkers: novel surrogates of small and large vessel disease? Journal of Hypertension, 29(9). pp. 1700-1702. (doi:10.1097/HJH.0b013e32834a3ceb)

Burger, D., Montezano, A. C., Nishigaki, N., He, Y., Carter, A., and Touyz, R. M. (2011) Endothelial Microparticle Formation by Angiotensin II Is Mediated via Ang II Receptor Type I/NADPH Oxidase/ Rho Kinase Pathways Targeted to Lipid Rafts. Arteriosclerosis, Thrombosis and Vascular Biology, 31(8). pp. 1898-1907. (doi:10.1161/ATVBAHA.110.222703)

Nguyen Dinh Cat, A., and Touyz, R.M. (2011) Cell signaling of angiotensin II on vascular tone: novel mechanisms. Current Hypertension Reports, 13(2). pp. 122-128. (doi:10.1007/s11906-011-0187-x)

Touati, S., Meziri, F., Devaux, S., Berthelot, A., Touyz, R.M., and Laurant, P. (2011) Exercise reverses metabolic syndrome in high-fat diet-induced obese rats. Medicine and Science in Sports and Exercise, 43(3). pp. 398-407. (doi:10.1249/MSS.0b013e3181eeb12d)

Touyz, R.M. (2011) Advancement in hypertension pathogenesis: some new concepts. Current Opinion in Nephrology and Hypertension, 20(2). pp. 105-106. (doi:10.1097/MNH.0b013e328343f526)

Touyz, R.M., Briones, A.M., Sedeek, M., Burger, D., and Montezano, A.C. (2011) NOX isoforms and reactive oxygen species in vascular health. Molecular Interventions, 11(1). pp. 27-35. (doi:10.1124/mi.11.1.5)

Briones, A.M., Tabet, F., Callera, G.E., Montezano, A.C., Yogi, A., He, Y., Quinn, M.T., Salaices, M., and Touyz, R.M. (2011) Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR. Journal of the American Society of Hypertension , 5(3). pp. 137-153. (doi:10.1016/j.jash.2011.02.001)

Callera, G.E., Yogi, A., Briones, A.M., Montezano, A.C., He, Y., Tostes, R.C.A., Schiffrin, E.L., and Touyz, R.M. (2011) Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: role of PDGFR. Cardiovascular Research, 91(4). pp. 720-731. (doi:10.1093/cvr/cvr131)

Meziri, F., Binda, D., Touati, S., Pellegrin, M., Berthelot, A., Touyz, R.M., and Laurant, P. (2011) Exercise aggravates cardiovascular risks and mortality in rats with disrupted nitric oxide pathway and treated with recombinant human erythropoietin. European Journal of Applied Physiology, 111(8). pp. 1929-1938. (doi:10.1007/s00421-011-1829-z)

Nguyen Dinh Cat, A., Briones, A.M., Callera, G.E., Yogi, A., He, Y., Montezano, A.C., and Touyz, R.M. (2011) Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors. Hypertension, 58(3). pp. 479-488. (doi:10.1161/HYPERTENSIONAHA.110.168872)

Rabi, D.M. et al. (2011) The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. Canadian Journal of Cardiology, 27(4). 415-433.e2. (doi:10.1016/j.cjca.2011.03.015)

Savoia, C.,, Burger, D., Nishigaki, N., Montezano, A., and Touyz, R.M. (2011) Angiotensin II and the vascular phenotype in hypertension. Expert Reviews in Molecular Medicine, 13(e11). pp. 1-25. (doi:10.1017/S1462399411001815)

Schiffrin, E.L., and Touyz, R.M. (2011) Oxidative stress in arterial hypertension and atherosclerosis. In: Pantopoulos, K. and Schipper, H. (eds.) Principles of Free Radical Biomedicine. Nova Science.

Tabet, F., Lambert, G., Cuesta Torres, L.F., Hou, L., Sotirchos, I., Touyz, R.M., Jenkins, A.J., Barter, P.J., and Rye, K.A. (2011) Lipid-free apolipoprotein A-I and discoidal reconstituted high-density lipoproteins differentially inhibit glucose-induced oxidative stress in human macrophages. Arteriosclerosis, Thrombosis and Vascular Biology, 31(5). pp. 1192-1200. (doi:10.1161/ATVBAHA.110.222000)

Touyz, R.M., and Briones, A.M. (2011) Reactive oxygen species and vascular biology: implications in human hypertension. Hypertension Research, 34(1). pp. 5-14. (doi:10.1038/hr.2010.201)

Yogi, A., Callera, G.E., Antunes, T.T., Tostes, R.C., and Touyz, R.M. (2011) Transient receptor potential melastatin 7 (TRPM7) cation channels, magnesium and the vascular system in hypertension. Circulation Journal, 75(2). pp. 237-245. (doi:10.1253/circj.CJ-10-1021)

Yogi, A., Callera, G.E., Aranha, A.B., Antunes, T.T., Graham, D., McBride, M., Dominiczak, A., and Touyz, R.M. (2011) Sphingosine-1-Phosphate-Induced Inflammation Involves Receptor Tyrosine Kinase Transactivation in Vascular Cells: Upregulation in Hypertension. Hypertension, 57(4). pp. 809-818. (doi:10.1161/HYPERTENSIONAHA.110.162719)

Yogi, A., Callera, G.E., OʼConnor, S.E., He, Y., Correa, J.W., Tostes, R.C., Mazur, A., and Touyz, R.M. (2011) Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia. Journal of Hypertension, 29(7). pp. 1400-1410. (doi:10.1097/HJH.0b013e32834786d6)

2010

Sedeek, M. et al. (2010) Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy. AJP: Renal Physiology, 299(6). F1348-F1358. (doi:10.1152/ajprenal.00028.2010)

Quinn, R.R. et al. (2010) The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part I - blood pressure measurement, diagnosis and assessment of risk. Canadian Journal of Cardiology, 26(5). pp. 241-248.

Montezano, A.C. et al. (2010) Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells. Circulation Research, 106(8). pp. 1363-1373. (doi:10.1161/CIRCRESAHA.109.216036)

Briones, A.M., and Touyz, R.M. (2010) Oxidative stress and hypertension: current concepts. Current Hypertension Reports, 12(2). pp. 135-142. (doi:10.1007/s11906-010-0100-z)

Burger, D., Nishigaki, N., and Touyz, R.M. (2010) New insights into molecular mechanisms of hypertension. Current Opinion in Nephrology and Hypertension, 19(2). pp. 160-162. (doi:10.1097/MNH.0b013e32833680c4)

Yogi, A., OʼConnor, S.E., Callera, G.E., Tostes, R.C., and Touyz, R.M. (2010) Receptor and nonreceptor tyrosine kinases in vascular biology of hypertension. Current Opinion in Nephrology and Hypertension, 19(2). pp. 169-176. (doi:10.1097/MNH.0b013e3283361c24)

Hackam, D.G. et al. (2010) The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. Canadian Journal of Cardiology, 26(5). pp. 249-58.

Montezano, A.C., Burger, D., Ceravolo, G.S., Yusuf, H., Montero, M., and Touyz, R.M. (2010) Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5. Clinical Science, 120(4). pp. 131-141. (doi:10.1042/CS20100384)

Montezano, A.C., Zimmerman, D., Yusuf, H., Burger, D., Chignalia, A.Z., Wadhera, V., van Leeuwen, F.N., and Touyz, R.M. (2010) Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium. Hypertension, 56(3). pp. 453-462. (doi:10.1161/HYPERTENSIONAHA.110.152058)

Yogi, A., Callera, G.E., Hipólito, U.V., Silva, C.R., Touyz, R.M., and Tirapelli, C.R. (2010) Ethanol-induced vasoconstriction is mediated via redox-sensitive cyclo-oxygenase-dependent mechanisms. Clinical Science, 118(11). pp. 657-668. (doi:10.1042/CS20090352)

2009

Khan, N.A. et al. (2009) The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 – therapy. Canadian Journal of Cardiology, 25(5). pp. 287-298. (doi:10.1016/S0828-282X(09)70492-1)

Yogi, A., Callera, G.E., Tostes, R., and Touyz, R.M. (2009) Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells. American Journal of Physiology: Heart and Circulatory Physiology, 296(2). R201-R207. (doi:10.1152/ajpregu.90602.2008)

Briones, A.M., and Touyz, R.M. (2009) Moderate exercise decreases inflammation and oxidative stress in hypertension: but what are the mechanisms? Hypertension, 54(6). pp. 1206-1208. (doi:10.1161/HYPERTENSIONAHA.109.136622)

Callera, G.E., He, Y., Yogi, A., Montezano, A.C., Paravicini, T., Yao, G., and Touyz, R.M. (2009) Regulation of the novel Mg2+ transporter transient receptor potential melastatin 7 (TRPM7) cation channel by bradykinin in vascular smooth muscle cells. Journal of Hypertension, 27(1). pp. 155-166. (doi:10.1097/HJH.0b013e3283190582)

Fu, A. et al. (2009) Loss of Lkb1 in adult β cells increases β cell mass and enhances glucose tolerance in mice. Cell Metabolism, 10(4). pp. 285-295. (doi:10.1016/j.cmet.2009.08.008)

Gava, E., Samad-Zadeh, A., Zimpelmann, J., Bahramifarid, N., Kitten, G.T., Santos, R.A., Touyz, R.M., and Burns, K.D. (2009) Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells. Nephrology, Dialysis, Transplantation, 24(6). pp. 1766-1773. (doi:10.1093/ndt/gfn736)

Javeshghani, D., Schiffrin, E.L., Sairam, M.R., and Touyz, R.M. (2009) Potentiation of vascular oxidative stress and nitric oxide-mediated endothelial dysfunction by high-fat diet in a mouse model of estrogen deficiency and hyperandrogenemia. Journal of the American Society of Hypertension , 3(5). pp. 295-305. (doi:10.1016/j.jash.2009.07.002)

Paravicini, T.M., Yogi, A., Mazur, A., and Touyz, R.M. (2009) Dysregulation of vascular TRPM7 and Annexin-1 is associated with endothelial dysfunction in inherited hypomagnesemia. Hypertension, 53(2). pp. 423-429. (doi:10.1161/HYPERTENSIONAHA.108.124651)

Sedeek, M., Hébert, R.L., Kennedy, C.R., Burns, K.D., and Touyz, R.M. (2009) Molecular mechanisms of hypertension: role of Nox family NADPH oxidases. Current Opinion in Nephrology and Hypertension, 18(2). pp. 122-127. (doi:10.1097/MNH.0b013e32832923c3)

Takami, K., Touyz, L.Z.G., and Touyz, R.M. (2009) Liquorice alert. British Dental Journal, 207(11). p. 519. (doi:10.1038/sj.bdj.2009.1090)

Touyz, R.M., and Callera, G.E. (2009) A new look at the eye: aldosterone and mineralocorticoid receptors as novel targets in retinal vasculopathy. Circulation Research, 104(1). pp. 9-11. (doi:10.1161/CIRCRESAHA.108.191288)

Touyz, R.M., Chignalia, A., and Sedeek, M. (2009) Reactive oxygen species, oxidative stress and hypertension. In: Shah, A. and Laurindo, F. (eds.) Studies on Cardiovascular Disorders. Series: Oxidative stress in applied basic research and clinical practice . Humana Press. ISBN 9781607616009

Touyz, R.M., and Montezano, A.C. (2009) Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification. Cardiovascular Research, 81(2). pp. 237-239. (doi:10.1093/cvr/cvn345)

White, M., Touyz, R.M., Tessier, Y., Van Le, V., Ross, H., and Sirois, M.G. (2009) Persistent elevation of VEGF and prostacyclin following poor cardiopulmonary adaptation to high altitude. Wilderness and Environmental Medicine, 20(1). pp. 97-98. (doi:10.1580/08-WEME-LE-248.1)

White, M., Touyz, R.M., Tessier, Y., Van Le, V., Ross, H., and Sirois, M.G. (2009) A cardiac and a kidney transplant patient above 6000 meters in Bolivia. Wilderness and Environmental Medicine, 20(1). pp. 99-100. (doi:10.1580/08-WEME-LE-249.1)

Xu, S., He, Y., Vokurkova, M., and Touyz, R.M. (2009) Endothelial cells negatively modulate reactive oxygen species generation in vascular smooth muscle cells: role of Thioredoxin. Hypertension, 54(2). pp. 427-433. (doi:10.1161/HYPERTENSIONAHA.109.133983)

2008

Touyz, R.M. (2008) Targeting the ailing endothelium – current concepts and future prospects. Canadian Journal of Cardiology, 24(Sup C). 38C-43C. (doi:10.1016/S0828-282X(08)71037-7)

Tabet, F., Schiffrin, E. L., Callera, G. E., He, Y., Yao, G., Ostman, A., Kappert, K., Tonks, N. K., and Touyz, R. M. (2008) Redox-Sensitive Signaling by Angiotensin II Involves Oxidative Inactivation and Blunted Phosphorylation of Protein Tyrosine Phosphatase SHP-2 in Vascular Smooth Muscle Cells From SHR. Circulation Research, 103(2). pp. 149-158. (doi:10.1161/CIRCRESAHA.108.178608)

Ebrahimian, T., and Touyz, R.M. (2008) Thioredoxin in vascular biology: role in hypertension. Antioxidants and Redox Signaling, 10(6). pp. 1127-1136. (doi:10.1089/ars.2007.1985)

Touyz, R.M., and Schiffrin, E.L. (2008) Reactive oxygen species and hypertension: a complex association. Antioxidants and Redox Signaling, 10(6). pp. 1041-1044. (doi:10.1089/ars.2007.2012)

Touyz, R.M. (2008) Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension. American Journal of Physiology: Heart and Circulatory Physiology, 294(3). H1103-H1118.

Paravicini, T. M., and Touyz, R.M. (2008) NADPH oxidases, reactive oxygen species and hypertension: clinical implications and therapeutic possibilities. Diabetes Care, 31(Supl.2). S170-S180. (doi:10.2337/dc08-s247)

Ebrahimian, T., Sairam, M.R., Schiffrin, E.L., and Touyz, R.M. (2008) Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause. American Journal of Physiology: Heart and Circulatory Physiology, 295(4). H1481-H1488. (doi:10.1152/ajpheart.00163.2008)

Khan, N.A. et al. (2008) The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapy. Canadian Journal of Cardiology, 24(6). pp. 465-475. (doi:10.1016/S0828-282X(08)70620-2)

Mercure, C., Yogi, A., Callera, G.E., Aranha, A.B., Bader, M., Ferreira, A.J., Santos, R.A.S., Walther, T., Touyz, R.M., and Reudelhuber, T.L. (2008) Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart. Circulation Research, 103(11). pp. 1319-1326. (doi:10.1161/CIRCRESAHA.108.184911)

Montezano, A.C., Callera, G.E., Yogi, A., He, Y., Tostes, R.C., He, G., Schiffrin, E.L., and Touyz, R.M. (2008) Aldosterone and Angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arteriosclerosis, Thrombosis and Vascular Biology, 28(8). pp. 1511-1518. (doi:10.1161/ATVBAHA.108.168021)

Montezano, A.C., and Touyz, R.M. (2008) Networking between systemic Angiotensin II and cardiac mineralocorticoid receptors. Hypertension, 52(6). pp. 1016-1018. (doi:10.1161/HYPERTENSIONAHA.108.121269)

Padwal, R.S. et al. (2008) The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1 – blood pressure measurement, diagnosis and assessment of risk. Canadian Journal of Cardiology, 24(6). pp. 455-463. (doi:10.1016/S0828-282X(08)70619-6)

Paravicini, T., Najii, S., and Touyz, R.M. (2008) Disturbed Mg++ transporters in hypertension. Journal of Hypertension, 26(12). pp. 2450-2451. (doi:10.1097/HJH.0b013e328317f029)

Park, Y.M., Lim, B.H., Touyz, R.M., and Park, J.B. (2008) Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat. Journal of Korean Medical Science, 23(6). pp. 1039-1045. (doi:10.3346/jkms.2008.23.6.1039)

Savoia, C., Touyz, R.M., Amiri, F., and Schiffrin, E.L. (2008) Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients. Hypertension, 51(2). pp. 432-439. (doi:10.1161/HYPERTENSIONAHA.107.103267)

Sontia, B., Montezano, A.C., Paravicini, T., Tabet, F., and Touyz, R.M. (2008) Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice: effects of magnesium. Hypertension, 51(4). pp. 915-921. (doi:10.1161/HYPERTENSIONAHA.107.100339)

Sontia, B., Mooney, J., Gaudet, L., and Touyz, R.M. (2008) Pseudohyperaldosteronism, liquorice, and hypertension. Journal of Clinical Hypertension, 10(2). pp. 153-157. (doi:10.1111/j.1751-7176.2008.07470.x)

Tian, T., McBride, M.W., Graham, D., Touyz, R., and Dominiczak, A.F. (2008) A systems biology approach for the sphingosine-1-phosphate signal transduction in vascular smooth muscle cell. Journal of Hypertension, 26(Suppl.). S148-S148.

Tostes, R.C., Fortes, Z.B., Callera, G.E., Montezano, A.C., Touyz, R.M., Webb, R.C., and Carvalho, M.H.C. (2008) Endothelin, sex and hypertension. Clinical Science, 114(2). pp. 85-97. (doi:10.1042/CS20070169)

Touyz, R.M. (2008) Apocynin, NADPH oxidase, and vascular cells: a complex matter. Hypertension, 51(2). pp. 172-174. (doi:10.1161/HYPERTENSIONAHA.107.103200)

Viel, E.C., Benkirane, K., Javeshghani, D., Touyz, R.M., and Schiffrin, E.L. (2008) Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats. American Journal of Physiology: Heart and Circulatory Physiology, 295(1). H281-H288. (doi:10.1152/ajpheart.00304.2008)

Yogi, A., Mercure, C., Touyz, J., Callera, G.E., Montezano, A.C., Aranha, A.B., Tostes, R.C., Reudelhuber, T., and Touyz, R.M. (2008) Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in Angiotensin II-dependent chronic hypertension. Hypertension, 51(2). pp. 500-506. (doi:10.1161/HYPERTENSIONAHA.107.103192)

Yzydorczyk, C. et al. (2008) Neonatal oxygen exposure in rats leads to cardiovascular and renal alterations in adulthood. Hypertension, 52(5). pp. 889-895. (doi:10.1161/HYPERTENSIONAHA.108.116251)

de Denus, S. et al. (2008) Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan. Annals of Pharmacotherapy, 42(7). pp. 925-932. (doi:10.1345/aph.1K657)

2007

Sontia, B., and Touyz, R.M. (2007) Magnesium transport in hypertension. Pathophysiology, 14(3-4). pp. 205-211. (doi:10.1016/j.pathophys.2007.09.005)

Touyz, R.M. (2007) Lifestyle and BP: making a healthy change. Perspectives in Cardiology, 23(7).

Khan, N.A. et al. (2007) The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. Canadian Journal of Cardiology, 23(7). pp. 539-550.

Padwal, R.S. et al. (2007) The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Canadian Journal of Cardiology, 23(7). pp. 529-538.

Tobe, S.W., Touyz, R.M., and Campbell, N.R.C. (2007) The Canadian Hypertension Education Program - a unique Canadian knowledge translation program. Canadian Journal of Cardiology, 23(7). pp. 551-555. (doi:10.1016/S0828-282X(07)70799-7)

Callera, G., Tostes, R., Savoia, C., Muscara, M.N., and Touyz, R.M. (2007) Vasoactive peptides in cardiovascular (patho)physiology. Expert Review of Cardiovascular Therapy, 5(3). pp. 531-552. (doi:10.1586/14779072.5.3.531)

Callera, G.E., Montezano, A.C.I., Yogi, A., Tostes, R.C.A., and Touyz, R.M. (2007) Vascular signaling through cholesterol-rich domains: implications in hypertension. Current Opinion in Nephrology and Hypertension, 16(2). pp. 90-104. (doi:10.1097/MNH.0b013e328040bfbd)

Sontia, B., and Touyz, R.M. (2007) Role of magnesium in hypertension. Archives of Biochemistry and Biophysics, 458(1). pp. 33-39. (doi:10.1016/j.abb.2006.05.005)

Vokurkova, M., Xu, S., and Touyz, R.M. (2007) Reactive oxygen species, cell growth, cell cycle progression and vascular remodeling in hypertension. Future Cardiology, 3(1). pp. 53-63. (doi:10.2217/14796678.3.1.53)

Ciuceis, C., Amiri, F., Iglarz, M., Cohn, J.S., Touyz, R.M., and Schiffrin, E.L. (2007) Synergistic vascular protective effects of combined low doses of PPARα and PPARγ activators in angiotensin II-induced hypertension in rats. British Journal of Pharmacology, 151(1). pp. 45-53. (doi:10.1038/sj.bjp.0707215)

Ebrahimian, T., He, Y., Schiffrin, E.L., and Touyz, R.M. (2007) Differential regulation of thioredoxin and NAD(P)H oxidase by Angiotensin II in male and female mice. Journal of Hypertension, 25(6). pp. 1263-1271. (doi:10.1097/HJH.0b013e3280acac60)

Fox, C.H., Timm, E.A., Smith, S.J., Touyz, R.M., Bush, E.G., and Wallace, P.K. (2007) A method for measuring intracellular free magnesium concentration in platelets using flow cytometry. Magnesium Research, 20(3). pp. 200-207.

Graham, D. et al. (2007) Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat - Congenic analysis. Hypertension, 50(6). pp. 1134-1141. (doi:10.1161/HYPERTENSIONAHA.107.095349)

Javeshghani, D., Sairam, M.R., Schiffrin, E.L., and Touyz, R.M. (2007) Increased blood pressure, vascular inflammation, and endothelial dysfunction in androgen-deficient follitropin receptor knockout male mice. Journal of the American Society of Hypertension , 1(5). pp. 353-361. (doi:10.1016/j.jash.2007.06.003)

Montezano, A.C., Amiri, F., Tostes, R.C., Touyz, R.M., and Schiffrin, E.L. (2007) Inhibitory effects of PPAR-γ on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Journal of the American Society of Hypertension , 1(2). pp. 150-160. (doi:10.1016/j.jash.2007.01.005)

Sampaio, W.O., Souza dos Santos, R.A., Faria-Silva, R., da Mata Machado, L.T., Schiffrin, E.L., and Touyz, R.M. (2007) Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via akt-dependent pathways. Hypertension, 49(1). pp. 185-192.

Savoia, C., Touyz, R.M., Volpe, M., and Schiffrin, E.L. (2007) Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients. Hypertension, 49(2). pp. 341-346. (doi:10.1161/01.HYP.0000253968.95136.b8)

Touyz, R.M. (2007) Reactive oxygen species and mediators of oxidative stress. In: Izzo, J.L. (ed.) Hypertension Primer. Lippincott Williams & Wilkins. ISBN 9780781782050

Touyz, R.M. (2007) Regulation of endothelial nitric oxide synthase by throbin. Hypertension, 49(3). pp. 429-431. (doi:10.1161/01.HYP.0000255955.75119.1a)

Touyz, R.M. (2007) Vascular remodeling, retinal arteries, and hypertension. Hypertension, 50(4). pp. 603-604. (doi:10.1161/HYPERTENSIONAHA.107.095638)

Touyz, R.M., Savoia, C., He, Y., Endemann, D., Pu, Q., Ko, E.A., DeCiuceis, C., Montezano, A.C., and Schiffrin, E.L. (2007) Increased inflammatory biomarkers in hypertensive type 2 diabetic patients: improvement after angiotensin II type 1 receptor blockade. Journal of the American Society of Hypertension , 1(3). pp. 189-199. (doi:10.1016/j.jash.2007.01.009)

Touyz, R.M., and Schiffrin, E.L. (2007) Angiotensin II and inflammation. In: Carey, R.M. (ed.) Hypertension and Hormone Mechanisms. Series: Contemporary endocrinology. Humana Press. ISBN 9781588294081

White, M. et al. (2007) Effects of combined candesartan and ACE inhibitors on BNP, markers of inflammation and oxidative stress, and glucose regulation in patients with symptomatic heart failure. Journal of Cardiac Failure, 13(2). pp. 86-94. (doi:10.1016/j.cardfail.2006.10.013)

Yogi, A., Callera, G.E., Montezano, A.C., Aranha, A.B., Tostes, R.C., Schiffrin, E.L., and Touyz, R.M. (2007) Endothelin-1, but not Ang II, activates MAP kinases through c-Src-independent Ras-Raf-dependent pathways in vascular smooth muscle cells. Arteriosclerosis, Thrombosis and Vascular Biology, 27(9). pp. 1960-1967. (doi:10.1161/ATVBAHA.107.146746)

Zargham, R., Touyz, R.M., and Thibault, G. (2007) α8 integrin overexpression in de-differentiated vascular smooth muscle cells attenuates migratory activity and restores the characteristics of the differentiated phenotype. Atherosclerosis, 195(2). pp. 303-312. (doi:10.1016/j.atherosclerosis.2007.01.005)

da Costa Goncalves, A.C. et al. (2007) Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function. American Journal of Physiology: Heart and Circulatory Physiology, 293(4). H2588-H2596. (doi:10.1152/ajpheart.00173.2007)

2006

Touyz, R.M., and Schiffrin, E.L. (2006) Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications. Vascular Pharmacology, 45(1). pp. 19-28. (doi:10.1016/j.vph.2005.11.014)

Touyz, R.M. (2006) Magnesium and hypertension. Current Opinion in Nephrology and Hypertension, 15(2). pp. 141-144. (doi:10.1097/01.mnh.0000214773.34480.d4)

Callera, G.E., Tostes, R.C., Yogi, A., Montezano, A.C., and Touyz, R.M. (2006) Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms. Clinical Science, 110(2). pp. 243-253. (doi:10.1042/CS20050307)

Ducharme, A. et al. (2006) Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support. Clinical Science, 110(4). pp. 483-489. (doi:10.1042/CS20050317)

Javeshghani, D., Sairam, M.R., Neves, M.F., Schiffrin, E.L., and Touyz, R.M. (2006) Angiotensin II induces vascular dysfunction without exacerbating blood pressure elevation in a mouse model of menopause-associated hypertension. Journal of Hypertension, 24(7). pp. 1365-1373. (doi:10.1097/01.hjh.0000234117.25401.f8)

Ko, E.A., Amiri, F., Pandey, N.R., Javeshghani, D., Leibovitz, E., Touyz, R.M., and Schiffrin, E.L. (2006) Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice. American Journal of Physiology: Heart and Circulatory Physiology, 292(4). H1789-H1795. (doi:10.1152/ajpheart.01118.2006)

Paravicini, T.M., and Touyz, R.M. (2006) Redox signaling in hypertension. Cardiovascular Research, 71(2). pp. 247-258. (doi:10.1016/j.cardiores.2006.05.001)

Savoia, C., Ebrahimian, T., He, Y., Gratton, J., Schiffrin, E.L., and Touyz, R.M. (2006) Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase. Journal of Hypertension, 24(12). pp. 2417-2422. (doi:10.1097/01.hjh.0000251902.85675.7e)

Savoia, C., Touyz, R.M., Endemann, D., Pu, Q., Ko, E.A., De Ciuceis, C., and Schriffin, E.L. (2006) Angiotensin receptor blocker added to previous antihypertensive agents on arteries of diabetic hypertensive patients. Hypertension, 48(2). pp. 271-277. (doi:10.1161/01.HYP.0000230234.84356.36)

Schiffrin, E.L., and Touyz, R.M. (2006) Oxidative stress in hypertension. In: Bourassa, M. and Tardif, J.-C. (eds.) Antioxidants in Cardiovascular Disease. Series: Developments in cardiovascular medicine (233). Springer. ISBN 9780387295527

Touyz, R.M. (2006) Lipid rafts take center stage in endothelial cell redox signaling by death receptors. Hypertension, 47(1). pp. 16-18. (doi:10.1161/01.HYP.0000196730.13216.f3)

Touyz, R.M. (2006) Mitochondrial redox control of matrix metalloproteinase signaling in resistance arteries. Arteriosclerosis, Thrombosis and Vascular Biology, 26(4). pp. 685-688. (doi:10.1161/01.ATV.0000216428.90962.60)

Touyz, R.M., He, Y., Montezano, A.C., Yao, G., Chubanov, V., Gudermann, T., and Callera, G.E. (2006) Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats. AJP: Regulatory, Integrative and Comparative Physiology, 290(1). R73-R78. (doi:10.1152/ajpregu.00515.2005)

Xu , S., and Touyz, R.M. (2006) Reactive oxygen species and vascular remodeling in hypertension: still alive. Canadian Journal of Cardiology, 22(11). pp. 947-951.

2005

Tabet, F., Schiffrin, E.L., and Touyz, R.M. (2005) Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: upregulation in spontaneously hypertensive rats. Journal of Hypertension, 23(11). pp. 2005-2012.

Santos, R.A.,, Ferreira, A.J., Pinheiro, S.V.B., Sampaio, W.O., Touyz, R.M., and Campagnole-Santos, M.J. (2005) Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs. Expert Opinion on Investigational Drugs, 14(8). pp. 1019-1031. (doi:10.1517/13543784.14.8.1019)

Touyz, R. (2005) Intracellular mechanisms involved in vascular remodeling of resistance arteries in hypertension: role of angiotensin II. Experimental Physiology, 90(4). pp. 449-455. (doi:10.1113/expphysiol.2005.030080)

Khan, N.A. et al. (2005) The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: part II - therapy. Canadian Journal of Cardiology, 21(8). pp. 657-672.

Savoia, C., Tabet, F., Yao, G., Schiffrin, E.L., and Touyz, R.M. (2005) Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats. Journal of Hypertension, 23(5). pp. 1037-1045.

Beaucage, P., Iglarz, M., Servant, M., Touyz, R.M., and Moreau, P. (2005) Position of Src tyrosine kinases in the interaction between angiotensin II and endothelin in in vivo vascular protein synthesis. Journal of Hypertension, 23(2). pp. 329-335.

Callera, G. E., Montezano, A.C., Alvaro, Y., Tostes, R.C., He, Y., Schriffin, E., and Touyz, R.M. (2005) c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension, 46(4). pp. 1032-1038. (doi:10.1161/01.HYP.0000176588.51027.35)

Callera, G.E., Touyz, R.M., Tostes, R.C., Yogi, A., He, Y., Malkinson, S., and Schriffin, E.L. (2005) Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src. Hypertension, 45(4). pp. 773-779. (doi:10.1161/01.HYP.0000154365.30593.d3)

Cruzado, M., Risler, N., Miatello, R., Yao, G., Schriffin, E., and Touyz, R.M. (2005) Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: Effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation. American Journal of Hypertension, 18(1). pp. 81-87. (doi:10.1016/j.amjhyper.2004.09.001)

De Ciuceis, C., Amiri, F., Brassard, P., Endemann, D.H., Touyz, R.M., and Schriffin, E.L. (2005) Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of Angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in Angiotensin-induced vascular injury. Arteriosclerosis, Thrombosis and Vascular Biology, 25(10). pp. 2106-2113. (doi:10.1161/01.ATV.0000181743.28028.57)

He, Y., Yao, G., Savoia, C., and Touyz, R.M. (2005) Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of Angiotensin II. Circulation Research, 96(2). pp. 207-215. (doi:10.1161/01.RES.0000152967.88472.3e)

Jamnik, V.K., Gledhill, N., Touyz, R.M., Campbell, N.R.C., Logan, A.G., Padwal, R., and Petrella, R. (2005) Lifestyle modifications to prevent and manage hypertension for exercise physiologists and fitness professionals. Canadian Journal of Applied Physiology, 30(6). pp. 754-761. (doi:10.1139/h05-154)

Padwal, R., Campbell, N.R.C., and Touyz, R.M. (2005) Applying the 2005 Canadian Hypertension Education Program recommendations: 3. Lifestyle modifications to prevent and treat hypertension. Canadian Medical Association Journal, 173(7). pp. 749-751. (doi:10.1503/cmaj.050186)

Schiffrin, E.L., and Touyz, R.M. (2005) Calcium, magnesium, and oxidative stress in hyperaldosteronism. Circulation, 111(7). pp. 830-831. (doi:10.1161/01.CIR.0000157186.95918.78)

Touyz, R.M. (2005) Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase. Hypertension, 45(4). pp. 530-537. (doi:10.1161/01.HYP.0000158845.49943.5e)

Touyz, R.M. (2005) Endothelial cell IL-8, a new target for Adiponectin: implications in vascular protection. Circulation Research, 97(12). pp. 1216-1219. (doi:10.1161/01.RES.0000196745.09234.36)

Touyz, R.M. (2005) Molecular and cellular mechanisms in vascular injury in hypertension: role of angiotensin II [editorial review]. Current Opinion in Nephrology and Hypertension, 14(2). pp. 125-131.

Touyz, R.M., Yao, G., Quinn, M.T., Pagano, P.J., and Schriffin, E.L. (2005) p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by Angiotensin II. Arteriosclerosis, Thrombosis and Vascular Biology, 25(3). pp. 512-518. (doi:10.1161/01.ATV.0000154141.66879.98)

Touyz, R.M., Yao, G., and Schiffrin, E.L. (2005) Role of the actin cytoskeleton in angiotensin II signaling in human vascular smooth muscle cells. Canadian Journal of Physiology and Pharmacology, 83(1). pp. 91-97. (doi:10.1139/y05-006)

2004

Touyz, R.M., Yao, G., Viel, E., Amiri, F., and Schiffrin, E.L. (2004) Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells. Journal of Hypertension, 22(6). pp. 1141-1149.

Touyz, R.M., Campbell, N., Logan, A., Gledhill, N., Petrella, R., and Padwal, R. (2004) The 2004 Canadian recommendations for the management of hypertension: Part III--Lifestyle modifications to prevent and control hypertension. Canadian Journal of Cardiology, 20(1). pp. 55-59.

Amiri, F., Virdis, A.,, Neves, M.F., Iglarz, M., Seidah, N.G., Touyz, R.M., Reudelhuber, T.L., and Schiffrin, E.L. (2004) Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation, 110(15). pp. 2233-2240. (doi:10.1161/01.CIR.0000144462.08345.B9)

Callera, G.E., Montezano, A.C., Touyz, R.M., Zorn, T.M.T., Carvalho, M.H., Fortes, Z.B., Nigro, D., Schriffin, E.L., and Tostes, R.C. (2004) ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats. Hypertension, 43(4). pp. 872-879. (doi:10.1161/01.HYP.0000117296.30296.14)

Daigle, C., Martens, F.M.A.C., Girardot, D., Dao, H., Touyz, R.M., and Moreau, P. (2004) Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo. BMC Cardiovascular Disorders, 4(6). (doi:10.1186/1471-2261-4-6)

Endemann, D.H., Pu, Q., De Ciuceis, C., Savoia, C., Virdis, A., Neves, M.F., Touyz, R.M., and Schriffin, E.L. (2004) Persistent remodeling of resistance arteries in type 2 diabetic patients on antihypertensive treatment. Hypertension, 43(2). pp. 399-404. (doi:10.1161/01.HYP.0000112029.03691.e7)

Endemann, D.H., Touyz, R.M., Iglarz, M., Savoia, C., and Schiffrin, E.L. (2004) Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension, 43(6). pp. 1252-1257. (doi:10.1161/01.HYP.0000128031.31572.a3)

Iglarz, M., Touyz, R.M., Viel, E.C., Amiri, F., and Schiffrin, E.L. (2004) Involvement of oxidative stress in the profibrotic action of aldosterone: interaction with the renin-angiotensin system. American Journal of Hypertension, 17(7). pp. 597-603. (doi:10.1016/j.amjhyper.2004.04.005)

Lochard, N., Thibault, G., Silversides, D.W., Touyz, R.M., and Reudelhuber, T.L. (2004) Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist. Circulation Research, 94(11). pp. 1451-1457. (doi:10.1161/01.RES.0000130654.56599.40)

Mabrouk, M.E., Diep, Q.N., Benkirane, K., Touyz, R.M., and Schriffin, E.L. (2004) SAM68: a downstream target of angiotensin II signaling in vascular smooth muscle cells in genetic hypertension. American Journal of Physiology: Heart and Circulatory Physiology, 286(5). H1954-H1962. (doi:10.1152/ajpheart.00134.2003)

Tabet, F., Savoia, C., Schiffrin, E.L., and Touyz, R.M. (2004) Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 44(2). pp. 200-208. (doi:10.1097/00005344-200408000-00009)

Touyz, R.M. (2004) Magnesium in clinical medicine. In: Maguire , M.E. (ed.) Encyclopedia of Bioscience. McGraw-Hill.

Touyz, R.M. (2004) Magnesium in clinical medicine. Frontiers in Bioscience, 9. pp. 1278-1293.

Touyz, R.M. (2004) Reactive oxygen species and angiotensin II signaling in vascular cells – implications in cardiovascular disease. Brazilian Journal of Medical and Biological Research, 37(8). pp. 1263-1273.

Touyz, R.M. (2004) Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension, 44(3). pp. 248-252. (doi:10.1161/01.HYP.0000138070.47616.9d)

Touyz, R.M., and Schiffren, E.L. (2004) Reactive oxygen species in vascular biology: implications in hypertension. Histochemistry and Cell Biology, 122. pp. 339-352.

Touyz, R.M., and Schiffrin, E.L. (2004) Hypertension and oxidant stress. In: Holtzman, J.L. (ed.) Atherosclerosis and Oxidant Stress. Kluwer Academic.

Virdis, A., Neves, M.F., Amiri, F., Touyz, R.M., and Schiffrin, E.L. (2004) Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice. Journal of Hypertension, 22(3). pp. 535-542.

2003

Touyz, R.M., and Yao, G. (2003) Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger. Clinical Science, 105(2). pp. 235-242.

Touyz, R.M. (2003) The role of angiotensin II in regulating vascular structural and functional changes in hypertension. Current Hypertension Reports, 5(2). pp. 155-164. (doi:10.1007/s11906-003-0073-2)

Callera, G.E., Touyz, R.M., Teixeira, S.A., Muscara, M.N., Carvalho, M.H., Fortes, Z.B., Nigro, D.N., Schiffrin, E.L., and Tostes, R.C. (2003) ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension. Hypertension, 42(4). pp. 811-817. (doi:10.1161/01.HYP.0000088363.65943.6C)

Fox, C.H., Ramsoomair, D., Carter, C., and Touyz, R.M. (2003) Magnesium disorders. In: Encyclopedia of Endocrinology. UNSPECIFIED.

Iglarz, M., Touyz, R.M., Amiri, F., Lavoie, M.F., Diep, Q.N., and Schriffin, E.L. (2003) Effect of peroxisome proliferator-activated receptor-α and -γ activators on vascular remodeling in endothelin-dependent hypertension. Arteriosclerosis, Thrombosis and Vascular Biology, 23(1). pp. 45-51. (doi:10.1161/01.ATV.0000047447.67827.CD)

Iglarz, M., Touyz, R.M., Viel, E.C., Paradis, P., Amiri, F., Diep, Q.N., and Schiffrin, E.L. (2003) Peroxisome proliferator-activated receptor-α and receptor-γ activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension. Hypertension, 42(4). pp. 737-743. (doi:10.1161/01.HYP.0000083511.91817.B1)

Javeshghani, D., Touyz, R.M., Sairam, M.R., Virdis, A., Neves, M.F., and Schiffrin, E.L. (2003) Attenuated responses to angiotensin II in follitropin receptor knockout mice, a model of menopause-associated hypertension. Hypertension, 42(4). pp. 761-767. (doi:10.1161/01.HYP.0000085331.22169.3F)

Pu, Q., Neves, M.F., Virdis, A., Touyz, R.M., and Schriffin, E.L. (2003) Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension, 42(1). pp. 49-55. (doi:10.1161/01.HYP.0000078357.92682.EC)

Schiffrin, E.L., and Touyz, R.M. (2003) Inflammation and vascular hypertrophy induced by angiotensin II: role of NADPH oxidase-derived reactive oxygen species independently of blood pressure elevation? Arteriosclerosis, Thrombosis and Vascular Biology, 23(5). pp. 707-709. (doi:10.1161/01.ATV.0000069907.12357.7E)

Schiffrin, E.L., and Touyz, R.M. (2003) Multiple actions of angiotensin II in hypertension. Journal of the American College of Cardiology, 42(5). pp. 911-913. (doi:10.1016/S0735-1097(03)00845-3)

Touyz, R.M. (2003) Activated oxygen metabolites: do they really play a role in angiotensin II-regulated vascular tone? Journal of Hypertension, 21(12). pp. 2235-2238.

Touyz, R.M. (2003) Pressure-induced expression of vascular neuronal nitric oxide synthase: adaptive or maladaptive response in arteries? Journal of Hypertension, 21(5). pp. 863-865.

Touyz, R.M. (2003) Reactive oxygen species and other mediators of oxidative stress. In: Izzo, J.L. and Black, H.R. (eds.) Hypertension Primer: the Essentials of High Blood Pressure. Lippincott Williams & Wilkins, pp. 52-55. ISBN 9780781745093

Touyz, R.M. (2003) Reactive oxygen species in vascular biology: Role in arterial hypertension. Expert Review of Cardiovascular Therapy, 1(1). pp. 91-106.

Touyz, R.M. (2003) Recent advances in intracellular signaling in hypertension. Current Opinion in Nephrology and Hypertension, 12(2). pp. 165-174.

Touyz, R.M. (2003) Role of magnesium in the pathogenesis of hypertension. In: Cittadini, A. and Wolf, F.I. (eds.) Magnesium: From Biochemistry and Cell Physiology to Clinical Implications. Series: Molecular aspects of medicine (24). Elsevier Science, pp. 107-136.

Touyz, R.M., Cruzado, M., Tabet, F., Yao, G., Salomon, S., and Schiffrin, E.L. (2003) Redox-dependent MAP kinase signaling by Ang II in vascular smooth muscle cells: role of receptor tyrosine kinase transactivation. Canadian Journal of Physiology and Pharmacology, 81(2). pp. 159-167. (doi:10.1139/y02-164)

Touyz, R.M., Tabet, F., and Schiffrin, E.L. (2003) Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension. Clinical and Experimental Pharmacology and Physiology, 30(11). pp. 860-866. (doi:10.1046/j.1440-1681.2003.03930.x)

Touyz, R.M., and Yao, G. (2003) Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats. Journal of Hypertension, 21(2). pp. 337-344.

Touyz, R.M., and Yao, G. (2003) Modulation of vascular smooth muscle cell growth by magnesium-role of mitogen-activated protein kinases. Journal of Cellular Physiology, 197(3). pp. 326-335. (doi:10.1002/jcp.10393)

Touyz, R.M., Yao, G., and Schriffin, E.L. (2003) c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells. Arteriosclerosis, Thrombosis and Vascular Biology, 23(6). pp. 981-987. (doi:10.1161/01.ATV.0000069236.27911.68)

Virdis, A., Iglarz, M., Neves, M.F., Amiri, F., Touyz, R.M., Rozen, R., and Schriffin, E.L. (2003) Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice. Arteriosclerosis, Thrombosis and Vascular Biology, 23(8). pp. 1352-1357. (doi:10.1161/01.ATV.0000083297.47245.DA)

2002

Tostes, R.C.A., Touyz, R.M., He, G., Chen, X., and Schiffrin, E.L. (2002) Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension. Clinical Science, 103(Sup 48). 25S-30S.

Endemann, D., Touyz, R.M., Yoa, G., and Schiffrin, E.L. (2002) Tyrosine kinase inhibition attenuates vasopressin-induced contraction of mesenteric resistance arteries: alterations in spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 40(1). pp. 123-132.

Touyz, R.M., Deschepper, C., Park, J.B., He, G., Chen, X., Neves, M.F.T., Virdis, A., and Schiffrin, E.L. (2002) Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats. Journal of Hypertension, 20(6). pp. 1127-1134. (doi:10.1097/00004872-200206000-00024)

Zarnke, K.B. et al. (2002) The 2001 Canadian recommendations for the management of hypertension: Part one--Assessment for diagnosis, cardiovascular risk, causes and lifestyle modification. Canadian Journal of Cardiology, 18(6). pp. 604-624.

Pu, Q., Touyz, R.M., and Schiffrin, E.L. (2002) Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats. Journal of Hypertension, 20(5). pp. 899-907. (doi:10.1097/00004872-200205000-00025)

Touyz, R.M. (2002) Impaired vasorelaxation in hypertension: beyond the endothelium. Journal of Hypertension, 20(3). pp. 371-373. (doi:10.1097/00004872-200203000-00007)

Deschepper, C.F., Picard, S., Thibault, G., Touyz, R.M., and Rouleau, J. (2002) Characterization of myocardium, isolated cardiomyocytes, and blood pressure in WKHA and WKY rats. American Journal of Physiology: Heart and Circulatory Physiology, 282(1). H149-H155. (doi:10.​1152/​ajpheart.​00672.​2001)

Berry, C., and Touyz, R.M. (2002) Recent advances in angiotensin II signaling. Brazilian Journal of Medical and Biological Research, 35(9). pp. 1001-1015.

Diep, Q.N., Amiri, F., Touyz, R.M., Cohn, J.S., Endemann, D., Neves, M.F., and Schriffin, E.L. (2002) PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation. Hypertension, 40(6). pp. 866-871. (doi:10.1161/01.HYP.0000037969.41360.CC)

Park, J.B., Touyz, R.M., Chen, X., and Schriffin, E.L. (2002) Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats. American Journal of Hypertension, 15(1). pp. 78-84. (doi:10.1016/S0895-7061(01)02233-6)

Tostes, R.C.A., Touyz, R.M., He, G., Ammarguellat, F., and Schiffrin, E.L. (2002) Endothelin a receptor blockade decreases expression of growth factors and collagen and improves matrix metalloproteinase-2 activity in kidneys from stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 39(6). pp. 892-900. (doi:10.1097/00005344-200206000-00015)

Touyz, R.M., Chen, X., Tabet, F., Yao, G., He, G., Quinn, M., Pagano, P.J., and Schriffin, E.L. (2002) Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II. Circulation Research, 90(11). pp. 1205-1213. (doi:10.1161/01.RES.0000020404.01971.2F)

Touyz, R.M., Pu, Q., He, G., Chen, X., Yao, G., Neves, M.F., and Viel, E. (2002) Effects of low dietary magnesium intake on development of hypertension in stroke-prone spontaneously hypertensive rats. Journal of Hypertension, 20(11). pp. 2221-2232. (doi:10.1097/00004872-200211000-00022)

Touyz, R.M., Wu, X.H., He, G., Steven, S., and Schriffin, E.L. (2002) Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased c-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats. Hypertension, 39(2). pp. 479-485. (doi:10.1161/hy02t2.102909)

Virdis, A., Neves, M.F., Amiri, F., Viel, E., Touyz, R.M., and Schriffin, E.L. (2002) Spironolactone improves Angiotensin-induced vascular changes and oxidative stress. Hypertension, 40(4). pp. 504-510. (doi:10.1161/01.HYP.0000034738.79310.06)

2001

El Mabrouk, M., Touyz, R.M., and Schiffrin, E.L. (2001) Differential ANG II-induced growth activation pathways in mesenteric artery smooth muscle cells from SHR. American Journal of Physiology: Heart and Circulatory Physiology, 281(1). H30-H39.

Diep, Q.N., El Mabrouk, M., Touyz, R.M., and Schiffrin, E.L. (2001) Expression of cell cycle proteins in blood vessels of angiotensin II-inused rats: role of AT(1) receptors. Hypertension, 37(Part 2). pp. 604-608.

Berry, C., Touyz, R., Dominiczak, A.F., Webb, R.C., and Johns, D.G. (2001) Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. American Journal of Physiology: Heart and Circulatory Physiology, 281(6). H2337-H2365.

Chen, X., Touyz, R.M., Park, J.B., and Schiffrin, E.L. (2001) Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. Hypertension, 38(3). pp. 606-611. (doi:10.1161/hy09t1.094005)

McAlister, F.A. et al. (2001) The 2000 Canadian recommendations for the management of hypertension: Part one--therapy. Canadian Journal of Cardiology, 17(5). pp. 543-559.

Touyz, R.M. (2001) Magnesium responsiveness to Ang II and ET-1 in vascular smooth muscle cells from spontaneously hypertensive rats. In: Rayssiguier , Y., Mazur , A. and Durlach, J. (eds.) Advances in Magnesium Research: Nutrition and Health. John Libbey: Eastleigh, England, pp. 341-347. ISBN 9780861966097

Touyz, R.M., He, G., El Mabrouk, M., Diep, Q., Mardigyan, V., and Schiffrin, E.L. (2001) Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar–Kyoto rats and spontaneously hypertensive rats. Journal of Hypertension, 19(3 Supp). pp. 553-559. (doi:10.1097/00004872-200103001-00006)

Touyz, R.M., He, G., El Mabrouk, M., and Schiffrin, E.L. (2001) p38 Map kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY. Hypertension, 37(Part 2). pp. 574-580.

Touyz, R.M., He, G., Wu, X.H., Park, J.B., Mabrouk, M.E., and Schiffrin, E.L. (2001) Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients. Hypertension, 38(1). pp. 56-64.

Touyz, R.M., Mercure, C., and Reudelhuber, T.L. (2001) Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms. Journal of Biological Chemistry, 276(17). pp. 13657-13663. (doi:10.1074/jbc.M008101200)

Touyz, R.M., and Schiffrin, E.L. (2001) Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways. Journal of Hypertension, 19(7). pp. 1245-1254. (doi:10.1097/00004872-200107000-00009)

Touyz, R.M., Wu, X., He, G., Park, J.B., Chen, X., Vacher, J., Rajapurohitam, V., and Schiffrin, E.L. (2001) Role of c-Src in the regulation of vascular contraction and Ca2+ signaling by angiotensin II in human vascular smooth muscle cells. Journal of Hypertension, 19(3). pp. 441-449. (doi:10.1097/00004872-200103000-00012)

2000

Touyz, R.M., and Schiffren, E.L. (2000) Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacological Reviews, 52(4). pp. 639-672.

Diep, Q.N., Touyz, R.M., and Schiffrin, E.L. (2000) Docosahexaenoic acid, a peroxisome proliferator-activated receptor- ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension, 36(5). pp. 851-855. (doi:10.1161/01.HYP.36.5.851)

Touyz, R.M., Turgeon, A., and Schiffrin, E.L. (2000) Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 36(Sup 1). S300-S304.

Touyz, R.M., and Schiffrin, E.L. (2000) Measurement of intracellular free calcium ion concentration in vascular smooth muscle cells using fura-2. In: Wang, D.H. (ed.) Angiotensin Protocols. Series: Methods in molecular medicine (51). Humana Press, pp. 341-353. ISBN 9780896037632 (doi:10.1385/1-59259-087-X:341)

Touyz, R.M. (2000) Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertension. Journal of Hypertension, 18(9). pp. 1177-1191.

El Mabrouk, M., Singh, A., Touyz, R.M., and Schiffrin, E.L. (2000) Antiproliferative effect of L-NAME on rat vascular smooth muscle cells. Life Sciences, 67(13). pp. 1613-1623. (doi:10.1016/S0024-3205(00)00744-X)

Tea, B.-S., Der Sarkissian, S., Touyz, R.M., Hamet, P., and deBlois, D. (2000) Proapoptotic and growth-inhibitory role of angiotensin II type 2 receptor in vascular smooth muscle cells of spontaneously hypertensive rats in vivo. Hypertension, 35(5). pp. 1069-1073. (doi:10.1161/01.HYP.35.5.1069)

Schiffrin, E.L., Park, J.B., Intengan, H.D., and Touyz, R.M. (2000) Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan. Circulation, 101(14). pp. 1653-1659. (doi:10.1161/01.CIR.101.14.1653)

Touyz, R.M., Jiang, L., and Sairiam, M.R. (2000) Follicle-stimulating hormone mediated calcium signaling by the alternatively spliced growth factor type I receptor. Biology of Reproduction, 62(4). pp. 1067-1074. (doi:10.1095/biolreprod62.4.1067)

Fareh, J., Touyz, R.M., Schiffrin, E.L., and Thibault, G. (2000) Altered cardiac endothelin receptors and protein kinase C in deoxycorticosterone-salt hypertensive rats. Journal of Molecular and Cellular Cardiology, 32(4). pp. 665-676. (doi:10.1006/jmcc.2000.1110)

Touyz, R.M. (2000) Oxidative stress and vascular damage in hypertension. Current Hypertension Reports, 2(1). pp. 98-105. (doi:10.1007/s11906-000-0066-3)

Touyz, R.M. (2000) Molecular and cellular mechanisms regulating vascular function and structure--implications in the pathogenesis of hypertension. Canadian Journal of Cardiology, 16(9). pp. 1137-1146.

Touyz, R.M., and Schiffrin, E.L. (2000) Measurement of phospholipase D activation in vascular smooth muscle cells. In: Wang, D.H. (ed.) Angiotensin Protocols. Series: Methods in molecular medicine (51). Humana Press, pp. 355-362. ISBN 9780896037632 (doi:10.1385/1-59259-087-X:355)

1999

Touyz, R.M., and Schiffrin, E.L. (1999) Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells. Hypertension, 34(4). pp. 976-982. (doi:10.1161/01.HYP.34.4.976)

Touyz, R.M., and Schiffrin, E.L. (1999) Activation of the Na+-H+ exchanger modulates angiotensin II stimulated Na+-dependent Mg2+ transport in vascular smooth muscle cells in genetic hypertension. Hypertension, 34(3). pp. 442-449. (doi:10.1161/01.HYP.34.3.442)

Touyz, R.M., and Milne, F.J. (1999) Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats. American Journal of Hypertension, 12(8). pp. 757-765. (doi:10.1016/S0895-7061(99)00064-3)

Babu, P.S., Jiang, L., Sairam, A.M., Touyz, R.M., and Sairam, M.R. (1999) Structural features and expression of an alternatively spliced growth factor type I receptor for follitropin signaling in the developing ovary. Molecular Cell Biology Research Communications, 2(1). pp. 21-27. (doi:10.1006/mcbr.1999.0139)

Endemann, D., Touyz, R.M., Li, J.-S., and Schiffrin, E.L. (1999) Altered angiotensin II-induced small artery contraction during the development of hypertension in spontaneously hypertensive rats. American Journal of Hypertension, 12(7). pp. 716-723. (doi:10.1016/S0895-7061(99)00036-9)

Touyz, R.M., Deng, L.-Y., He, G., Wu, X.-H., and Schiffrin, E.L. (1999) Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: role of extracellular signal-regulated kinases. Journal of Hypertension, 17(7). pp. 907-916.

Touyz, R.M., El Mabrouk, M., He, G., Wu, X.-H., and Schiffrin, E.L. (1999) Mitogen-activated protein/extracellular signal regulated kinase inhibition attenuates angiotensin II mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells. Circulation Research, 84(5). pp. 505-515. (doi:10.1161/01.RES.84.5.505)

Touyz, R.M., He, G., Deng, L.-Y., and Schiffrin, E.L. (1999) Role of extracellular signal-regulated kinases in angiotensin II stimulated contraction of smooth muscle cells from human resistance arteries. Circulation, 99(3). pp. 392-399. (doi:10.1161/01.CIR.99.3.392)

Touyz, R.M., Endemann, D., He, G., Li, J.-S., and Schiffrin, E.L. (1999) Role of AT2 receptors in angiotensin II stimulated contraction of small mesenteric arteries in young SHR. Hypertension, 33(1). pp. 366-372. (doi:10.1161/01.HYP.33.1.366)

Schiffrin, E. L., and Touyz, R.M. (1999) Role of endothelin-1 in hypertension. Hypertension, 34(4). pp. 876-881. (doi:10.1161/01.HYP.34.4.876)

1998

Touyz, R.M., Laurant, P., and Schiffrin, E.L. (1998) Effect of magnesium on calcium responses to vasopressin in vascular smooth muscle cells of spontaneously hypertensive rats. Journal of Pharmacology and Experimental Therapeutics, 284(3). pp. 998-1005.

Li, J.S., Touyz, R.M., and Schiffrin, E.L. (1998) Effects of AT1 and AT2 angiotensin receptor antagonists in angiotensin II-infused rats. Hypertension, 31(1). pp. 487-492. (doi:10.1161/01.HYP.31.1.487)

Schiffrin, E.L., and Touyz, R.M. (1998) Vascular biology of endothelin. Journal of Cardiovascular Pharmacology, 32(Sup 3). S2-S13.

Sharifi, A.M., He, G., Touyz, R.M., and Schiffrin, E.L. (1998) Vascular endothelin-1 expression and effect of an endothelin ETA antagonist on structure and function of small arteries from stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 31(Sup 1). S309-S312.

Touyz, R.M., Fareh, J., Thibault, G., and Schiffrin, E.L. (1998) Endothelin-1 signaling is altered in cardiac cells from deoxycorticosterone acetate-salt hypertensive rats. Journal of Cardiovascular Pharmacology, 31(Sup 1). S179-S181. (doi:10.1097/00005344-199800001-00051)

1997

Touyz, R.M., and Schiffrin, E.L. (1997) Growth factors mediate intracellular signaling in vascular smooth muscle cells through protein kinase C-linked pathways. Hypertension, 30(6). pp. 1440-1447. (doi:10.1161/01.HYP.30.6.1440)

Touyz, R.M., and Schiffrin, E.L. (1997) Role of calcium influx and intracellular calcium stores in angiotensin II-mediated calcium hyper-responsiveness in smooth muscle from spontaneously hypertensive rats. Journal of Hypertension, 15(2). pp. 1431-1439.

Fareh, J., Touyz, R.M., Schiffrin, E.L., and Thibault, G. (1997) Cardiac type-1 angiotensin II receptor status in deoxycorticosterone acetate salt hypertension in rats. Hypertension, 30(5). pp. 1253-1259. (doi:10.1161/01.HYP.30.5.1253)

Lacroix, A., Tremblay, J., Touyz, R.M., Deng, L.Y., Lariviere, R., Cusson, J.R., Schiffrin, E.L., and Hamet, P. (1997) Abnormal adrenal and vascular responses to vasopressin mediated by a v1-vasopressin receptor in a patient with adrenocorticotropin-independent macronodular adrenal hyperplasia, cushing's syndrome, and orthostatic hypotension. Journal of Clinical Endocrinology and Metabolism, 82(8). pp. 2414-2422. (doi:10.1210/jc.82.8.2414)

Touyz, R.M., and Schiffrin, E.L. (1997) Angiotensin II regulates vascular smooth muscle cell ph, contraction, and growth via tyrosine kinase dependent signaling pathways. Hypertension, 30(2). pp. 222-229. (doi:10.1161/01.HYP.30.2.222)

Touyz, R.M., and Schiffrin, E.L. (1997) Reply to letter by S. Bund regarding 'differential effects of vasopressin and endothelin-1 on vascular contractile and calcium responses in pressurized small arteries from SHR. Journal of Hypertension, 15(8). pp. 912-913.

Methot, D., LaPointe, M.C., Touyz, R.M., Yang, X.-P., Carretero, O.A., Deschepper, C.F., Schiffrin, E.L., and Thibault, G. (1997) Tissue targeting of angiotensin peptides. Journal of Biological Chemistry, 272(20). pp. 12994-12999. (doi:10.1074/jbc.272.20.12994)

Laurant, P., Touyz, R.M., and Schiffrin, E.L. (1997) Effect of magnesium on vascular tone and reactivity in pressurized mesenteric resistance arteries from spontaneously hypertensive rats. Canadian Journal of Physiology and Pharmacology, 75(4). pp. 293-300. (doi:10.1139/y97-044)

Touyz, R.M., Picard, S., Schiffrin, E.L., and Deschepper, C.F. (1997) Cyclic GMP inhibits a pharmacologically distinct Na+/H+ exchanger variant in cultured rat astrocytes via an extracellular site of action. Journal of Neurochemistry, 68(4). pp. 1451-1461. (doi:10.1046/j.1471-4159.1997.68041451.x)

Lawant, P., Touyz, R.M., and Schiffrin, E.L. (1997) Effect of pressurization on mechanical properties of mesenteric small arteries from spontaneously hypertensive rats. Journal of Vascular Research, 34(2). pp. 117-125. (doi:10.1159/000159209)

Schiffrin, E.L., Intengan, H.D., Thibault, G., and Touyz, R.M. (1997) Clinical significance of endothelin in cardiovascular disease. Current Opinion in Cardiology, 12. pp. 354-367.

1996

Touyz, R.M., Fareh, J., Thibault, G., and Schiffrin, E.L. (1996) Intracellular calcium2+ modulation by angiotensin II and endothelin-1 in cardiomyocytes and fibroblasts from hypertrophied hearts of spontaneously hypertensive rats. Hypertension, 28(5). pp. 797-805.

Touyz, R.M., and Schiffrin, E.L. (1996) Angiotensin II and vasopressin modulate intracellular free magnesium in vascular smooth muscle cells through Na+-dependent protein kinase C pathways. Journal of Biological Chemistry, 271(40). pp. 24353-24358. (doi:10.1074/jbc.271.40.24353)

Touyz, R.M., Deng, L.Y., Li, J.S., and Schiffrin, E.L. (1996) Differential effects of vasopressin and endothelin-1 on vascular contractile and calcium responses in pressurized small arteries from spontaneously hypertensive rats. Journal of Hypertension, 14(8). pp. 983-991.

Touyz, R.M., and Schiffrin, E.L. (1996) Tyrosine kinase signaling pathways modulate angiotensin II induced calcium ([Ca2+]i) transients in vascular smooth muscle cells. Hypertension, 27(5). pp. 1097-1103. (doi:10.1161/01.HYP.27.5.1097)

Touyz, R.M., Sventek, P., Lariviere, R., Thibault, G., Fareh, J., Reudelhuber, T., and Schiffrin, E.L. (1996) Cytosolic calcium changes induced by angiotensin II in neonatal rat atrial and ventricular cardiomyocytes are mediated via angiotensin II subtype 1 receptors. Hypertension, 27(5). pp. 1090-1096. (doi:10.1161/01.HYP.27.5.1090)

Touyz, R.M., Fareh, J., Thibault, G., Tolloczko, B., Larivière, R., and Schiffrin, E.L. (1996) Modulation of Ca2+ transients in neonatal and adult rat cardiomyocytes by angiotensin II and endothelin-1. American Journal of Physiology: Heart and Circulatory Physiology, 270(3). H857-H868.

Fareh, J., Touyz, R.M., Schiffrin, E.L., and Thibault, G. (1996) Endothelin-1 and angiotensin II receptors in cells from rat hypertrophied heart: receptor regulation and intracellular Ca2+ modulation. Circulation Research, 78(2). pp. 302-311. (doi:10.1161/01.RES.78.2.302)

Yang, X.-P., Touyz, R.M., Nguyen, P.V., Li, Y.D., Li, J.-S., and Schiffrin, E.L. (1996) Endothelin-1 and vasopressin signalling in blood vessels of young SHR in comparison to adult SHR. Hypertension Research, 19(2). pp. 121-132. (doi:10.1291/hypres.19.121)

1995

Fareh, J., Touyz, R.M., Thibault, G., and Schiffrin, E.L. (1995) Basal and stimulated angiotensin II-induced cytosolic free calcium in adult rat cardiomyocytes and fibroblasts after volume overload. Hypertension, 26(6.2). pp. 1149-1153. (doi:10.1161/​01.HYP.26.6.1149)

Touyz, R.M., Deng, L.Y., and Schiffrin, E.L. (1995) ETB mediated calcium and contractile responses in mesenteric small arteries from WKY and SHR. Hypertension, 26(6). pp. 1041-1045. (doi:10.1161/​01.HYP.26.6.1041)

Touyz, R.M., and Schiffrin, E.L. (1995) Treatment of non-insulin-dependent diabetic hypertensive patients with Ca2+ channel blockers is associated with increased platelet sensitivity to insulin. American Journal of Hypertension, 8(12). pp. 1214-1221. (doi:10.1016/0895-7061(95)00249-9)

Schiffrin, E.L., Larivière, R., Li, J.S., Sventek, P., and Touyz, R.M. (1995) Endothelin-1 gene expression and vascular hypertrophy in DOCA-salt hypertension compared to spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology, 22(s1). S188-S190. (doi:10.1111/j.1440-1681.1995.tb02875.x)

Schiffrin, E.L., Larivière, R., and Touyz, R.M. (1995) ETA and ETB receptors on vascular smooth muscle cells from mesenteric vessels of SHR. Clinical and Experimental Pharmacology and Physiology, 22(s1). S193-S194. (doi:10.1111/j.1440-1681.1995.tb02877.x)

Touyz, R.M., and Milne, F.J. (1995) Alterations in intracellular cations and cell membrane ATPase activity in patients with malignant hypertension. Journal of Hypertension, 13(8). pp. 867-874.

Touyz, R.M., Larivière, R., and Schiffrin, E.L. (1995) Endothelin influences pHi of human platelets through protein kinase C mediated pathways. Thrombosis Research, 78(1). pp. 55-65. (doi:10.1016/0049-3848(95)00034-8)

Schiffrin, E.L., Larivière, R., Li, J.S., Sventek, P., and Touyz, R.M. (1995) Deoxycorticosterone acetate plus salt induces overexpression of vascular endothelin-1 and severe vascular hypertrophy in spontaneously hypertensive rats. Hypertension, 25(4). pp. 769-773. (doi:10.1161/​01.HYP.25.4.769)

Touyz, R.M., and Schiffrin, E.L. (1995) Role of protein kinase C in the antiaggregatory effects of endothelin-l on human platelets. Clinical Science, 88(3). pp. 277-283. (doi:10.1042/cs0880277)

Touyz, R.M., Tolloczko, B., and Schiffrin, E.L. (1995) Blunted attenuation of angiotensin II-mediated Ca2+ transients by insulin in cultured unpassaged vascular smooth muscle cells from spontaneously hypertensive rats. American Journal of Hypertension, 8(2). pp. 104-112. (doi:10.1016/0895-7061(94)00173-9)

Schiffrin, E.L., Larivière, R., Li, J.S., Sventek, P., and Touyz, R.M. (1995) Enhanced expression of endothelin-1 gene may cause blood pressure independent vascular hypertrophy. In: Fourth International Conference on Endothelin, London, UK, 23-26 Apr 1995, S5-S8.

Touyz, R.M., Deng, L.Y., and Schiffrin, E.L. (1995) Ca2+ and contractile responses of resistance vessels of WKY and SHR to endothelin-1. In: Fourth International Conference on Endothelin, London, UK, 23-26 Apr 1995, S193-S196.

Touyz, R.M., Fareh, J., Thibault, G., Larivière, R., and Schiffrin, E.L. (1995) Modulation of Ca2+ transients in neonatal and adult rat cardiomyocytes by endothelin-1. In: Fourth International Conference on Endothelin, London, UK, 23-26 Apr 1995, S297-S299.

Touyz, R.M., Larivière, R., and Schiffrin, E.L. (1995) Endothelin receptor subtypes in mesenteric vascular smooth muscle cells of spontaneously hypertensive rats. Canadian Journal of Physiology and Pharmacology, 73(9). pp. 1262-1273. (doi:10.1139/y95-178)

Touyz, R.M., Panz, V., and Milne, F.J. (1995) Relations between magnesium, calcium and plasma renin activity in black and white hypertensive patients. Mineral and Electrolyte Metabolism, 21(6). pp. 417-422.

1994

Touyz, R.M., and Schiffrin, E.L. (1994) Blunted inhibition by insulin of agonist-stimulated calcium, pH and aggregatory responses in platelets from hypertensive patients. Journal of Hypertension, 12(11). pp. 1255-1263.

Touyz, R.M., and Schiffrin, E.L. (1994) Insulin-induced Ca2+ transport is altered in vascular smooth muscle cells of SHR. Hypertension, 23(6.2). pp. 931-935. (doi:10.1161/​01.HYP.23.6.931)

Touyz, R.M., Tolloczko, B., and Schiffrin, E.L. (1994) Mesenteric vascular smooth muscle cells from SHR display increased Ca2+ responses to angiotensin II but not to endothelin-1. Journal of Hypertension, 12(6). pp. 663-673.

Touyz, R.M., Tolloczko, B., and Schiffren, E.L. (1994) Insulin attenuates agonist-evoked calcium transients in vascular smooth muscle cells. Hypertension, 23(I). I-23. (doi:10.1161/​01.HYP.23.1_Suppl.I25)

1993

Touyz, R.M., and Schiffrin, E.L. (1993) The effect of angiotensin II on platelet intracellular free magnesium and calcium ionic concentrations in essential hypertension. Journal of Hypertension, 11(5). pp. 551-558.

Touyz, R.M., Milne, F.J., and Reinach, S.G. (1993) Altered calcium binding to erythrocyte membranes in essential hypertension: relation to magnesium. Journal of Human Hypertension, 7(1). pp. 59-64.

Touyz, R.M., and Schiffrin, E.L. (1993) Signal transduction in hypertension: part I. Current Opinion in Nephrology and Hypertension, 2(1). pp. 5-16.

Touyz, R.M., and Schiffrin, E.L. (1993) Signal transduction in hypertension: part II. Current Opinion in Nephrology and Hypertension, 2(1). pp. 17-26.

Touyz, R.M., Milne, F.J., and Reinach, S.G. (1993) Racial differences in cell membrane ATPases and cellular cation content in urban South African normotensive and hypertensive subjects. American Journal of Hypertension, 6(8). pp. 693-700. (doi:10.1093/ajh/6.8.693)

Touyz, R.M., and Schiffrin, E.L. (1993) Biology of blood vessels in hypertension. Cardiology in Review, 1(2). pp. 87-96.

Touyz, R.M., and Schiffrin, E.L. (1993) Effects of angiotensin II and endothelin-1 on platelet aggregation and cytosolic pH and free Ca2+ concentrations in essential hypertension. Hypertension, 22. pp. 853-862. (doi:10.1161/​01.HYP.22.6.853)

1992

Touyz, R.M., Milne, F.J., and Reinach, S.G. (1992) Platelet and erythrocyte Mg2+, Ca2+, Na+, K+ and cell membrane adenosine triphosphatase activity in essential hypertension in blacks. Journal of Hypertension, 10(6). pp. 571-578.

Touyz, R.M., Milne, F.J., and Reinach, S.G. (1992) Intracellular Mg2+, Ca2+, Na+ and K+ in platelets and erythrocytes of essential hypertensive patients: relation to blood pressure. Clinical and Experimental Hypertension, a14(6). pp. 1189-1209. (doi:10.3109/10641969209038200)

1991

Touyz, R.M. (1991) Magnesium supplementation as an adjuvant to synthetic calcium channel antagonists in the treatment of hypertension. Medical Hypotheses, 36(2). pp. 140-141. (doi:10.1016/0306-9877(91)90256-X)

Touyz, R.M., Milne, F.J., and Marshall, P.R. (1991) Altered cations and muscle membrane ATPase activity in deoxycorticosterone acetate-salt spontaneously hypertensive rats. Journal of Hypertension, 9(8). pp. 737-750.

1990

England, M.J., Panz, V.R., Joffe, B.I., Touyz, R.M., Shires, R., and Seftel, H.C. (1990) The effect of magnesium sulphate infusion on circulating catecholamine levels in severe gestational proteinuric hypertension. A report of 8 cases. South African Medical Journal, 78(11). pp. 688-690.

Touyz, R.M., and Milne, F.J. (1990) Some cellular events in hypertension - an overview. Cardiovascular Journal of South Africa, 1(3).

Touyz, R.M., Milne, F.J., and Reinach, S.G. (1990) Twenty-four hour ambulatory blood pressure in therapeutically resistant hypertensive patients. Journal of Human Hypertension, 4(4). pp. 393-396.

Touyz, R.M., Milne, F.J., Soicher, E., Neutel, J., Barlow, C., and Reinach, G.S. (1990) Circadian blood pressure variability in essential and secondary hypertension. Cardiovascular Journal of South Africa, 1(3). pp. 125-132.

1989

Touyz, R.M., Rathakrishnan, S., Reinach, S.G., and Milne, F.J. (1989) Hypertension, alcohol and cations in urban black and coloured South Africans. South African Medical Journal, 75(02). pp. 109-113.

Touyz, R.M., Rathakrishnan, S., Adam, E., Sonnekus, M., Reinach, S.G., and Milne, F.J. (1989) The relationship between magnesium, calcium, sodium, potassium and blood pressure in South African adult males. Magnesium, 8(3-4). pp. 145-153.

Touyz, R.M. (1989) Aetiology of hypertension in blacks. In: Milne, F.J. and Sareli, P. (eds.) Hypertension and Rheumatic Heart Disease in Black South Africans. Helm Publishing: Johannesberg, South Africa, pp. 6-9.

1988

Touyz, R.M., Kelly, A., Tollman, S., and Milne, F.J. (1988) An assessment of internships at the teaching hospitals of the University of Witwatersrand. South African Medical Journal, 74(08). pp. 173-177.

1987

Touyz, R.M., Milne, F.J., Seflel, M.C., and Reinach, S.G. (1987) Magnesium, calcium, sodium and potassium status in normotensive and hypertensive Johannesburg residents. South African Medical Journal, 72. pp. 377-381.

This list was generated on Mon Mar 2 10:16:18 2015 GMT.
Number of items: 336.

Articles

Beattie, C. J., Fulton, R. L., Higgins, P., Padmanabhan, S., McCallum, L., Walters, M. R., Dominiczak, A. F., Touyz, R. M., and Dawson, J. (2014) Allopurinol initiation and change in blood pressure in older adults with hypertension. Hypertension, 64(5). pp. 1102-1107. (doi:10.1161/HYPERTENSIONAHA.114.03953)

Dipchand, A.I., White, M., Manlhiot, C., Pollock-BarZiv, S., Allain-Rooney, T., West, L., He, Y., and Touyz, R.M. (2014) Myocyte growth, repair, and oxidative stress following pediatric heart transplantation. Pediatric Transplantation, 18(7). pp. 764-770. (doi:10.1111/petr.12337)

Touyz, R. M. (2014) Linking LOX-1 and arginase II through mitochondria: a novel paradigm in endothelial dysfunction. Circulation Research, 115(4). pp. 412-414. (doi:10.1161/CIRCRESAHA.114.304550)

Jha, J. C. et al. (2014) Genetic targeting or pharmacologic inhibition of NADPH oxidase Nox4 provides renoprotection in long-term diabetic nephropathy. Journal of the American Society of Nephrology, 25(6). pp. 1237-1254. (doi:10.1681/ASN.2013070810)

Wilkinson-Berka, J. L. et al. (2014) NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy. Antioxidants and Redox Signaling, 20(17). pp. 2726-2740. (doi:10.1089/ars.2013.5357)

Montezano, A. C., and Touyz, R. M. (2014) Mammalian target of Rapamycin: a novel pathway in vascular calcification. Canadian Journal of Cardiology, 30(5). pp. 482-484. (doi:10.1016/j.cjca.2014.03.001)

Small, H. Y., Montezano, A. C., Rios, F. J., Savoia, C., and Touyz, R. M. (2014) Hypertension due to antiangiogenic cancer therapy with vascular endothelial growth factor inhibitors: understanding and managing a new syndrome. Canadian Journal of Cardiology, 30(5). pp. 534-543. (doi:10.1016/j.cjca.2014.02.011)

Montezano, A. C., Nguyen Dinh Cat, A., Rios, F. J., and Touyz, R. M. (2014) Angiotensin II and vascular injury. Current Hypertension Reports, 16(6). p. 431. (doi:10.1007/s11906-014-0431-2)

Marco, E. et al. (2014) Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune–inflammatory responses in diabetic Apoe −/− mice. Diabetologia, 57(3). pp. 633-642. (doi:10.1007/s00125-013-3118-3)

Campbell, N. et al. (2014) The World Hypertension League and International Society of Hypertension call on governments, nongovernmental organizations, and the food industry to work to reduce dietary sodium. Journal of Clinical Hypertension, 16(2). pp. 99-100. (doi:10.1111/jch.12245)

Campbell, N.R.C. et al. (2014) The International Society of Hypertension and World Hypertension League call on governments, nongovernmental organizations and the food industry to work to reduce dietary sodium. Journal of Hypertension, 32(2). pp. 446-447. (doi:10.1097/HJH.0000000000000079)

Montezano, A. C., and Touyz, R. M. (2014) Reactive oxygen species, vascular noxs, and hypertension: focus on translational and clinical research. Antioxidants and Redox Signaling, 20(1). pp. 164-182. (doi:10.1089/ars.2013.5302)

Bruder-Nascimento, T., Chinnasamy, P., Riascos-Bernal, D.F., Cau, S.B., Callera, G.E., Touyz, R.M., Tostes, R.C., and Sibinga, N.E.S. (2014) Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation. Journal of Molecular and Cellular Cardiology, 66. pp. 18-26. (doi:10.1016/j.yjmcc.2013.10.013)

Weber, M.A. et al. (2014) Clinical practice guidelines for the management of hypertension in the community a statement by the American society of hypertension and the international society of hypertension. Journal of Hypertension, 32(1). pp. 3-15. (doi:10.1097/HJH.0000000000000065)

Jennings, G. L.R., and Touyz, R. M. (2014) Response to European Society of Hypertension and European Society of Cardiology Guidelines and the muted enthusiasm for home blood pressure monitoring. Hypertension, 63(2). e6. (doi:10.1161/HYPERTENSIONAHA.113.02423)

Zimmerman, D. L., Ruzicka, M., Hebert, P., Fergusson, D., Touyz, R. M., and Burns, K. D. (2014) Short daily versus conventional hemodialysis for hypertensive patients: a randomized cross-over study. PLoS ONE, 9(5). e97135. (doi:10.1371/journal.pone.0097135)

Thibodeau, J., Nasrallah, R., Carter, A., He, Y., Touyz, R., Hébert, R.L., and Kennedy, C.R.J. (2013) PTGER1 deletion attenuates renal injury in diabetic mouse models. American Journal of Pathology, 183(6). pp. 1789-1802. (doi:10.1016/j.ajpath.2013.08.022)

White, M. et al. (2013) Cardiac signaling molecules and plasma biomarkers after cardiac transplantation: impact of tacrolimus versus cyclosporine. Journal of Heart and Lung Transplantation, 32(12). pp. 1222-1232. (doi:10.1016/j.healun.2013.09.010)

Yogi, A. et al. (2013) Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain. Cellular Signalling, 25(11). pp. 2163-2175. (doi:10.1016/j.cellsig.2013.07.002)

Sedeek, M., Nasrallah, R., Touyz, R.M., and Hebert, R.L. (2013) NADPH oxidases, reactive oxygen species, and the kidney: friend and foe. Journal of the American Society of Nephrology, 24(10). pp. 1512-1518. (doi:10.1681/ASN.2012111112)

Nguyen Dinh Cat, A., Montezano, A.C., Burger, D., and Touyz, R.M. (2013) Angiotensin II, NADPH oxidase, and redox signaling in the vasculature. Antioxidants and Redox Signaling, 19(10). pp. 1110-1120. (doi:10.1089/ars.2012.4641)

Gray, S.P. et al. (2013) NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation, 127(18). pp. 1888-1902. (doi:10.1161/CIRCULATIONAHA.112.132159)

Chalmers, J., Arima, H., Harrap, S., Touyz, R.M., and Park, J.B. (2013) Global survey of current practice in management of hypertension as reported by societies affiliated with the international society of hypertension. Journal of Hypertension, 31(5). pp. 1043-1048. (doi:10.1097/HJH.0b013e32835f7eef)

Touyz, R.M. (2013) Combination antihypertensive treatment with aliskiren and blockers of the renin-angiotensin system—reassurance but with a note of caution. Canadian Journal of Cardiology, 29(5). pp. 521-523. (doi:10.1016/j.cjca.2013.02.020)

Der Sarkissian, S., Tea, B., Touyz, R.M., deBlois, D., and Hale, T.M. (2013) Role of angiotensin II type 2 receptor during regression of cardiac hypertrophy in spontaneously hypertensive rats. Journal of the American Society of Hypertension, 7(2). pp. 118-127. (doi:10.1016/j.jash.2013.01.002)

Burger, D., Schock, S., Thompson, C.S., Montezano, A.C., Hakim, A.M., and Touyz, R.M. (2013) Microparticles: biomarkers and beyond. Clinical Science, 124(7). pp. 423-441. (doi:10.1042/CS20120309)

Jennings, G.L.R., and Touyz, R.M. (2013) Hypertension guidelines: more challenges highlighted by Europe. Hypertension, 62(4). pp. 660-665. (doi:10.1161/HYPERTENSIONAHA.113.02034)

Montezano, A.C., and Touyz, R.M. (2013) Mechanosensitive regulation of cortactin by p47phox: a new paradigm in cytoskeletal remodeling. Circulation Research, 112(12). pp. 1522-1525. (doi:10.1161/CIRCRESAHA.113.301495)

Sedeek, M. et al. (2013) Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes. Clinical Science, 124(3). pp. 191-202. (doi:10.1042/CS20120330)

Sedeek, M. et al. (2012) Oxidative stress, Nox isoforms and complications of diabetes—potential targets for novel therapies. Journal of Cardiovascular Translational Research, 5(4). pp. 509-518. (doi:10.1007/s12265-012-9387-2)

Montezano, A.C., and Touyz, R.M. (2012) Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies. Annals of Medicine, 44(S1). S2-S16. (doi:10.3109/07853890.2011.653393)

Montezano, A.C., and Touyz, R.M. (2012) Molecular mechanisms of hypertension—reactive oxygen species and antioxidants: a basic science update for the clinician. Canadian Journal of Cardiology, 28(3). pp. 288-295. (doi:10.1016/j.cjca.2012.01.017)

Burger, D., and Touyz, R.M. (2012) Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells. Journal of the American Society of Hypertension , 6(2). pp. 85-99. (doi:10.1016/j.jash.2011.11.003)

Briones, A.M. et al. (2012) Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction. Hypertension, 59(9). pp. 1069-1078. (doi:10.1161/HYPERTENSIONAHA.111.190223)

Burger, D., Gutsol, A., Carter, A., Allan, D.S., Touyz, R.M., and Burns, K.D. (2012) Human cord blood CD133+ cells exacerbate ischemic acute kidney injury in mice. Nephrology, Dialysis, Transplantation, 27(10). pp. 3781-3789. (doi:10.1093/ndt/gfs110)

Burger, D., Kwart, D.G., Montezano, A.C., Read, N.C., Kennedy, C.R.J., Thompson, C.S., and Touyz, R.M. (2012) Microparticles induce cell cycle arrest through redox-sensitive processes in endothelial cells: implications in vascular senescence. Journal of the American Heart Association, 1(3). e001842-e001842. (doi:10.1161/JAHA.112.001842)

Burger, D., Veerabhadrappa, P., Charchar, F., Tomaszewski, M., Harrap, S., Carlberg, B., and Touyz, R.M. (2012) Report of the first International Society of Hypertension (ISH) Trainee/New Investigator Symposium: A Global Hypertension Initiative. Journal of Hypertension, 30(3). pp. 631-632. (doi:10.1097/HJH.0b013e32834f8267)

Chignalia, A.Z. et al. (2012) Testosterone induces vascular smooth muscle cell migration by NADPH oxidase and c-Src-dependent pathways. Hypertension, 59(6). pp. 1263-1271. (doi:10.1161/HYPERTENSIONAHA.111.180620)

Montezano, A.C., and Touyz, R.M. (2012) Reactive oxygen species and endothelial function - role of nitric oxide synthase uncoupling and nox family Nicotinamide Adenine Dinucleotide Phosphate oxidases. Basic and Clinical Pharmacology and Toxicology, 110(1). pp. 87-94. (doi:10.1111/j.1742-7843.2011.00785.x)

Paravicini, T.M., Montezano, A.C., Yusuf, H., and Touyz, R.M. (2012) Activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: influence of hypertension and angiotensin II. Journal of the American Society of Hypertension , 6(3). pp. 169-178. (doi:10.1016/j.jash.2012.01.002)

Rocha, J.T., Hipolito, U.V., Callera, G.E., Yogi, A., Filho, A., Bendhack, L.M., Touyz, R.M., and Tirapelli, C.R. (2012) Ethanol induces vascular relaxation via redox-sensitive and nitric oxide-dependent pathways. Vascular Pharmacology, 56(1-2). pp. 74-83. (doi:10.1016/j.vph.2011.11.006)

Touyz, R.M. (2012) New insights into mechanisms of hypertension. Current Opinion in Nephrology and Hypertension, 21(2). pp. 119-121. (doi:10.1097/MNH.0b013e328350a50f)

Touyz, R.M., and Montezano, A.C. (2012) Vascular Nox4: a multifarious NADPH oxidase. Circulation Research, 110(9). pp. 1159-1161. (doi:10.1161/CIRCRESAHA.112.269068)

Veerabhadrappa, P., Burger, D., Charchar, F., Tomaszewski, M., Carlberg, B., Harrap, S., and Touyz, R.M. (2012) Council for High Blood Pressure Research/InterAmerican Society of Hypertension/International Society of Hypertension: First New Investigators Symposium at the High Blood Pressure Research 2011 Scientific Sessions. Hypertension, 59(2). pp. 382-383. (doi:10.1161/HYPERTENSIONAHA.111.185421)

White, M., Montezano, A.C., and Touyz, R.M. (2012) Angiotensin II signalling and calcineurin in cardiac fibroblasts: differential effects of calcineurin inhibitors FK506 and cyclosporine A. Therapeutic Advances in Cardiovascular Disease, 6(1). pp. 5-14. (doi:10.1177/1753944711432901)

Yogi, A., Callera, G.E., Mecawi, A.S., Batalhão, M.E., Carnio, E.C., Antunes-Rodrigues, J., Queiroz, R.H., Touyz, R.M., and Tirapelli, C.R. (2012) Acute ethanol intake induces superoxide anion generation and mitogen-activated protein kinase phosphorylation in rat aorta: A role for angiotensin type 1 receptor. Toxicology and Applied Pharmacology, 264(3). pp. 470-478. (doi:10.1016/j.taap.2012.08.029)

Al Ghouleh, I. et al. (2011) Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling. Free Radical Biology and Medicine, 51(7). pp. 1271-1288. (doi:10.1016/j.freeradbiomed.2011.06.011)

Chung, Y. et al. (2011) Vascular progenitor recruitment in critically ill patients with acute kidney injury. Clinical and Investigative Medicine, 34(5). E304.

Nguyen Dinh Cat, A., and Touyz, R.M. (2011) A new look at the renin–angiotensin system--focusing on the vascular system. Peptides, 32(10). pp. 2141-2150. (doi:10.1016/j.peptides.2011.09.010)

Cascino, T., Csanyi, G., Al Ghouleh, I., Montezano, A.C., Touyz, R.M., Haurani, M.J., and Pagano, P.J. (2011) Adventitia-derived hydrogen peroxide impairs relaxation of the rat carotid artery via smooth muscle cell p38 mitogen-activated protein kinase. Antioxidants and Redox Signaling, 15(6). pp. 1507-1515. (doi:10.1089/ars.2010.3631)

Touyz, R.M., and Grassi, G. (2011) Renal biomarkers: novel surrogates of small and large vessel disease? Journal of Hypertension, 29(9). pp. 1700-1702. (doi:10.1097/HJH.0b013e32834a3ceb)

Burger, D., Montezano, A. C., Nishigaki, N., He, Y., Carter, A., and Touyz, R. M. (2011) Endothelial Microparticle Formation by Angiotensin II Is Mediated via Ang II Receptor Type I/NADPH Oxidase/ Rho Kinase Pathways Targeted to Lipid Rafts. Arteriosclerosis, Thrombosis and Vascular Biology, 31(8). pp. 1898-1907. (doi:10.1161/ATVBAHA.110.222703)

Nguyen Dinh Cat, A., and Touyz, R.M. (2011) Cell signaling of angiotensin II on vascular tone: novel mechanisms. Current Hypertension Reports, 13(2). pp. 122-128. (doi:10.1007/s11906-011-0187-x)

Touati, S., Meziri, F., Devaux, S., Berthelot, A., Touyz, R.M., and Laurant, P. (2011) Exercise reverses metabolic syndrome in high-fat diet-induced obese rats. Medicine and Science in Sports and Exercise, 43(3). pp. 398-407. (doi:10.1249/MSS.0b013e3181eeb12d)

Touyz, R.M. (2011) Advancement in hypertension pathogenesis: some new concepts. Current Opinion in Nephrology and Hypertension, 20(2). pp. 105-106. (doi:10.1097/MNH.0b013e328343f526)

Touyz, R.M., Briones, A.M., Sedeek, M., Burger, D., and Montezano, A.C. (2011) NOX isoforms and reactive oxygen species in vascular health. Molecular Interventions, 11(1). pp. 27-35. (doi:10.1124/mi.11.1.5)

Briones, A.M., Tabet, F., Callera, G.E., Montezano, A.C., Yogi, A., He, Y., Quinn, M.T., Salaices, M., and Touyz, R.M. (2011) Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR. Journal of the American Society of Hypertension , 5(3). pp. 137-153. (doi:10.1016/j.jash.2011.02.001)

Callera, G.E., Yogi, A., Briones, A.M., Montezano, A.C., He, Y., Tostes, R.C.A., Schiffrin, E.L., and Touyz, R.M. (2011) Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: role of PDGFR. Cardiovascular Research, 91(4). pp. 720-731. (doi:10.1093/cvr/cvr131)

Meziri, F., Binda, D., Touati, S., Pellegrin, M., Berthelot, A., Touyz, R.M., and Laurant, P. (2011) Exercise aggravates cardiovascular risks and mortality in rats with disrupted nitric oxide pathway and treated with recombinant human erythropoietin. European Journal of Applied Physiology, 111(8). pp. 1929-1938. (doi:10.1007/s00421-011-1829-z)

Nguyen Dinh Cat, A., Briones, A.M., Callera, G.E., Yogi, A., He, Y., Montezano, A.C., and Touyz, R.M. (2011) Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors. Hypertension, 58(3). pp. 479-488. (doi:10.1161/HYPERTENSIONAHA.110.168872)

Rabi, D.M. et al. (2011) The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. Canadian Journal of Cardiology, 27(4). 415-433.e2. (doi:10.1016/j.cjca.2011.03.015)

Savoia, C.,, Burger, D., Nishigaki, N., Montezano, A., and Touyz, R.M. (2011) Angiotensin II and the vascular phenotype in hypertension. Expert Reviews in Molecular Medicine, 13(e11). pp. 1-25. (doi:10.1017/S1462399411001815)

Tabet, F., Lambert, G., Cuesta Torres, L.F., Hou, L., Sotirchos, I., Touyz, R.M., Jenkins, A.J., Barter, P.J., and Rye, K.A. (2011) Lipid-free apolipoprotein A-I and discoidal reconstituted high-density lipoproteins differentially inhibit glucose-induced oxidative stress in human macrophages. Arteriosclerosis, Thrombosis and Vascular Biology, 31(5). pp. 1192-1200. (doi:10.1161/ATVBAHA.110.222000)

Touyz, R.M., and Briones, A.M. (2011) Reactive oxygen species and vascular biology: implications in human hypertension. Hypertension Research, 34(1). pp. 5-14. (doi:10.1038/hr.2010.201)

Yogi, A., Callera, G.E., Antunes, T.T., Tostes, R.C., and Touyz, R.M. (2011) Transient receptor potential melastatin 7 (TRPM7) cation channels, magnesium and the vascular system in hypertension. Circulation Journal, 75(2). pp. 237-245. (doi:10.1253/circj.CJ-10-1021)

Yogi, A., Callera, G.E., Aranha, A.B., Antunes, T.T., Graham, D., McBride, M., Dominiczak, A., and Touyz, R.M. (2011) Sphingosine-1-Phosphate-Induced Inflammation Involves Receptor Tyrosine Kinase Transactivation in Vascular Cells: Upregulation in Hypertension. Hypertension, 57(4). pp. 809-818. (doi:10.1161/HYPERTENSIONAHA.110.162719)

Yogi, A., Callera, G.E., OʼConnor, S.E., He, Y., Correa, J.W., Tostes, R.C., Mazur, A., and Touyz, R.M. (2011) Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia. Journal of Hypertension, 29(7). pp. 1400-1410. (doi:10.1097/HJH.0b013e32834786d6)

Sedeek, M. et al. (2010) Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy. AJP: Renal Physiology, 299(6). F1348-F1358. (doi:10.1152/ajprenal.00028.2010)

Quinn, R.R. et al. (2010) The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part I - blood pressure measurement, diagnosis and assessment of risk. Canadian Journal of Cardiology, 26(5). pp. 241-248.

Montezano, A.C. et al. (2010) Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells. Circulation Research, 106(8). pp. 1363-1373. (doi:10.1161/CIRCRESAHA.109.216036)

Briones, A.M., and Touyz, R.M. (2010) Oxidative stress and hypertension: current concepts. Current Hypertension Reports, 12(2). pp. 135-142. (doi:10.1007/s11906-010-0100-z)

Burger, D., Nishigaki, N., and Touyz, R.M. (2010) New insights into molecular mechanisms of hypertension. Current Opinion in Nephrology and Hypertension, 19(2). pp. 160-162. (doi:10.1097/MNH.0b013e32833680c4)

Yogi, A., OʼConnor, S.E., Callera, G.E., Tostes, R.C., and Touyz, R.M. (2010) Receptor and nonreceptor tyrosine kinases in vascular biology of hypertension. Current Opinion in Nephrology and Hypertension, 19(2). pp. 169-176. (doi:10.1097/MNH.0b013e3283361c24)

Hackam, D.G. et al. (2010) The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. Canadian Journal of Cardiology, 26(5). pp. 249-58.

Montezano, A.C., Burger, D., Ceravolo, G.S., Yusuf, H., Montero, M., and Touyz, R.M. (2010) Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5. Clinical Science, 120(4). pp. 131-141. (doi:10.1042/CS20100384)

Montezano, A.C., Zimmerman, D., Yusuf, H., Burger, D., Chignalia, A.Z., Wadhera, V., van Leeuwen, F.N., and Touyz, R.M. (2010) Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium. Hypertension, 56(3). pp. 453-462. (doi:10.1161/HYPERTENSIONAHA.110.152058)

Yogi, A., Callera, G.E., Hipólito, U.V., Silva, C.R., Touyz, R.M., and Tirapelli, C.R. (2010) Ethanol-induced vasoconstriction is mediated via redox-sensitive cyclo-oxygenase-dependent mechanisms. Clinical Science, 118(11). pp. 657-668. (doi:10.1042/CS20090352)

Khan, N.A. et al. (2009) The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 – therapy. Canadian Journal of Cardiology, 25(5). pp. 287-298. (doi:10.1016/S0828-282X(09)70492-1)

Yogi, A., Callera, G.E., Tostes, R., and Touyz, R.M. (2009) Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells. American Journal of Physiology: Heart and Circulatory Physiology, 296(2). R201-R207. (doi:10.1152/ajpregu.90602.2008)

Briones, A.M., and Touyz, R.M. (2009) Moderate exercise decreases inflammation and oxidative stress in hypertension: but what are the mechanisms? Hypertension, 54(6). pp. 1206-1208. (doi:10.1161/HYPERTENSIONAHA.109.136622)

Callera, G.E., He, Y., Yogi, A., Montezano, A.C., Paravicini, T., Yao, G., and Touyz, R.M. (2009) Regulation of the novel Mg2+ transporter transient receptor potential melastatin 7 (TRPM7) cation channel by bradykinin in vascular smooth muscle cells. Journal of Hypertension, 27(1). pp. 155-166. (doi:10.1097/HJH.0b013e3283190582)

Fu, A. et al. (2009) Loss of Lkb1 in adult β cells increases β cell mass and enhances glucose tolerance in mice. Cell Metabolism, 10(4). pp. 285-295. (doi:10.1016/j.cmet.2009.08.008)

Gava, E., Samad-Zadeh, A., Zimpelmann, J., Bahramifarid, N., Kitten, G.T., Santos, R.A., Touyz, R.M., and Burns, K.D. (2009) Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells. Nephrology, Dialysis, Transplantation, 24(6). pp. 1766-1773. (doi:10.1093/ndt/gfn736)

Javeshghani, D., Schiffrin, E.L., Sairam, M.R., and Touyz, R.M. (2009) Potentiation of vascular oxidative stress and nitric oxide-mediated endothelial dysfunction by high-fat diet in a mouse model of estrogen deficiency and hyperandrogenemia. Journal of the American Society of Hypertension , 3(5). pp. 295-305. (doi:10.1016/j.jash.2009.07.002)

Paravicini, T.M., Yogi, A., Mazur, A., and Touyz, R.M. (2009) Dysregulation of vascular TRPM7 and Annexin-1 is associated with endothelial dysfunction in inherited hypomagnesemia. Hypertension, 53(2). pp. 423-429. (doi:10.1161/HYPERTENSIONAHA.108.124651)

Sedeek, M., Hébert, R.L., Kennedy, C.R., Burns, K.D., and Touyz, R.M. (2009) Molecular mechanisms of hypertension: role of Nox family NADPH oxidases. Current Opinion in Nephrology and Hypertension, 18(2). pp. 122-127. (doi:10.1097/MNH.0b013e32832923c3)

Takami, K., Touyz, L.Z.G., and Touyz, R.M. (2009) Liquorice alert. British Dental Journal, 207(11). p. 519. (doi:10.1038/sj.bdj.2009.1090)

Touyz, R.M., and Callera, G.E. (2009) A new look at the eye: aldosterone and mineralocorticoid receptors as novel targets in retinal vasculopathy. Circulation Research, 104(1). pp. 9-11. (doi:10.1161/CIRCRESAHA.108.191288)

Touyz, R.M., and Montezano, A.C. (2009) Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification. Cardiovascular Research, 81(2). pp. 237-239. (doi:10.1093/cvr/cvn345)

White, M., Touyz, R.M., Tessier, Y., Van Le, V., Ross, H., and Sirois, M.G. (2009) Persistent elevation of VEGF and prostacyclin following poor cardiopulmonary adaptation to high altitude. Wilderness and Environmental Medicine, 20(1). pp. 97-98. (doi:10.1580/08-WEME-LE-248.1)

White, M., Touyz, R.M., Tessier, Y., Van Le, V., Ross, H., and Sirois, M.G. (2009) A cardiac and a kidney transplant patient above 6000 meters in Bolivia. Wilderness and Environmental Medicine, 20(1). pp. 99-100. (doi:10.1580/08-WEME-LE-249.1)

Xu, S., He, Y., Vokurkova, M., and Touyz, R.M. (2009) Endothelial cells negatively modulate reactive oxygen species generation in vascular smooth muscle cells: role of Thioredoxin. Hypertension, 54(2). pp. 427-433. (doi:10.1161/HYPERTENSIONAHA.109.133983)

Touyz, R.M. (2008) Targeting the ailing endothelium – current concepts and future prospects. Canadian Journal of Cardiology, 24(Sup C). 38C-43C. (doi:10.1016/S0828-282X(08)71037-7)

Tabet, F., Schiffrin, E. L., Callera, G. E., He, Y., Yao, G., Ostman, A., Kappert, K., Tonks, N. K., and Touyz, R. M. (2008) Redox-Sensitive Signaling by Angiotensin II Involves Oxidative Inactivation and Blunted Phosphorylation of Protein Tyrosine Phosphatase SHP-2 in Vascular Smooth Muscle Cells From SHR. Circulation Research, 103(2). pp. 149-158. (doi:10.1161/CIRCRESAHA.108.178608)

Ebrahimian, T., and Touyz, R.M. (2008) Thioredoxin in vascular biology: role in hypertension. Antioxidants and Redox Signaling, 10(6). pp. 1127-1136. (doi:10.1089/ars.2007.1985)

Touyz, R.M., and Schiffrin, E.L. (2008) Reactive oxygen species and hypertension: a complex association. Antioxidants and Redox Signaling, 10(6). pp. 1041-1044. (doi:10.1089/ars.2007.2012)

Touyz, R.M. (2008) Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension. American Journal of Physiology: Heart and Circulatory Physiology, 294(3). H1103-H1118.

Paravicini, T. M., and Touyz, R.M. (2008) NADPH oxidases, reactive oxygen species and hypertension: clinical implications and therapeutic possibilities. Diabetes Care, 31(Supl.2). S170-S180. (doi:10.2337/dc08-s247)

Ebrahimian, T., Sairam, M.R., Schiffrin, E.L., and Touyz, R.M. (2008) Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause. American Journal of Physiology: Heart and Circulatory Physiology, 295(4). H1481-H1488. (doi:10.1152/ajpheart.00163.2008)

Khan, N.A. et al. (2008) The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapy. Canadian Journal of Cardiology, 24(6). pp. 465-475. (doi:10.1016/S0828-282X(08)70620-2)

Mercure, C., Yogi, A., Callera, G.E., Aranha, A.B., Bader, M., Ferreira, A.J., Santos, R.A.S., Walther, T., Touyz, R.M., and Reudelhuber, T.L. (2008) Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart. Circulation Research, 103(11). pp. 1319-1326. (doi:10.1161/CIRCRESAHA.108.184911)

Montezano, A.C., Callera, G.E., Yogi, A., He, Y., Tostes, R.C., He, G., Schiffrin, E.L., and Touyz, R.M. (2008) Aldosterone and Angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arteriosclerosis, Thrombosis and Vascular Biology, 28(8). pp. 1511-1518. (doi:10.1161/ATVBAHA.108.168021)

Montezano, A.C., and Touyz, R.M. (2008) Networking between systemic Angiotensin II and cardiac mineralocorticoid receptors. Hypertension, 52(6). pp. 1016-1018. (doi:10.1161/HYPERTENSIONAHA.108.121269)

Padwal, R.S. et al. (2008) The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1 – blood pressure measurement, diagnosis and assessment of risk. Canadian Journal of Cardiology, 24(6). pp. 455-463. (doi:10.1016/S0828-282X(08)70619-6)

Paravicini, T., Najii, S., and Touyz, R.M. (2008) Disturbed Mg++ transporters in hypertension. Journal of Hypertension, 26(12). pp. 2450-2451. (doi:10.1097/HJH.0b013e328317f029)

Park, Y.M., Lim, B.H., Touyz, R.M., and Park, J.B. (2008) Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat. Journal of Korean Medical Science, 23(6). pp. 1039-1045. (doi:10.3346/jkms.2008.23.6.1039)

Savoia, C., Touyz, R.M., Amiri, F., and Schiffrin, E.L. (2008) Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients. Hypertension, 51(2). pp. 432-439. (doi:10.1161/HYPERTENSIONAHA.107.103267)

Sontia, B., Montezano, A.C., Paravicini, T., Tabet, F., and Touyz, R.M. (2008) Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice: effects of magnesium. Hypertension, 51(4). pp. 915-921. (doi:10.1161/HYPERTENSIONAHA.107.100339)

Sontia, B., Mooney, J., Gaudet, L., and Touyz, R.M. (2008) Pseudohyperaldosteronism, liquorice, and hypertension. Journal of Clinical Hypertension, 10(2). pp. 153-157. (doi:10.1111/j.1751-7176.2008.07470.x)

Tian, T., McBride, M.W., Graham, D., Touyz, R., and Dominiczak, A.F. (2008) A systems biology approach for the sphingosine-1-phosphate signal transduction in vascular smooth muscle cell. Journal of Hypertension, 26(Suppl.). S148-S148.

Tostes, R.C., Fortes, Z.B., Callera, G.E., Montezano, A.C., Touyz, R.M., Webb, R.C., and Carvalho, M.H.C. (2008) Endothelin, sex and hypertension. Clinical Science, 114(2). pp. 85-97. (doi:10.1042/CS20070169)

Touyz, R.M. (2008) Apocynin, NADPH oxidase, and vascular cells: a complex matter. Hypertension, 51(2). pp. 172-174. (doi:10.1161/HYPERTENSIONAHA.107.103200)

Viel, E.C., Benkirane, K., Javeshghani, D., Touyz, R.M., and Schiffrin, E.L. (2008) Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats. American Journal of Physiology: Heart and Circulatory Physiology, 295(1). H281-H288. (doi:10.1152/ajpheart.00304.2008)

Yogi, A., Mercure, C., Touyz, J., Callera, G.E., Montezano, A.C., Aranha, A.B., Tostes, R.C., Reudelhuber, T., and Touyz, R.M. (2008) Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in Angiotensin II-dependent chronic hypertension. Hypertension, 51(2). pp. 500-506. (doi:10.1161/HYPERTENSIONAHA.107.103192)

Yzydorczyk, C. et al. (2008) Neonatal oxygen exposure in rats leads to cardiovascular and renal alterations in adulthood. Hypertension, 52(5). pp. 889-895. (doi:10.1161/HYPERTENSIONAHA.108.116251)

de Denus, S. et al. (2008) Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan. Annals of Pharmacotherapy, 42(7). pp. 925-932. (doi:10.1345/aph.1K657)

Sontia, B., and Touyz, R.M. (2007) Magnesium transport in hypertension. Pathophysiology, 14(3-4). pp. 205-211. (doi:10.1016/j.pathophys.2007.09.005)

Touyz, R.M. (2007) Lifestyle and BP: making a healthy change. Perspectives in Cardiology, 23(7).

Khan, N.A. et al. (2007) The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. Canadian Journal of Cardiology, 23(7). pp. 539-550.

Padwal, R.S. et al. (2007) The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Canadian Journal of Cardiology, 23(7). pp. 529-538.

Tobe, S.W., Touyz, R.M., and Campbell, N.R.C. (2007) The Canadian Hypertension Education Program - a unique Canadian knowledge translation program. Canadian Journal of Cardiology, 23(7). pp. 551-555. (doi:10.1016/S0828-282X(07)70799-7)

Callera, G., Tostes, R., Savoia, C., Muscara, M.N., and Touyz, R.M. (2007) Vasoactive peptides in cardiovascular (patho)physiology. Expert Review of Cardiovascular Therapy, 5(3). pp. 531-552. (doi:10.1586/14779072.5.3.531)

Callera, G.E., Montezano, A.C.I., Yogi, A., Tostes, R.C.A., and Touyz, R.M. (2007) Vascular signaling through cholesterol-rich domains: implications in hypertension. Current Opinion in Nephrology and Hypertension, 16(2). pp. 90-104. (doi:10.1097/MNH.0b013e328040bfbd)

Sontia, B., and Touyz, R.M. (2007) Role of magnesium in hypertension. Archives of Biochemistry and Biophysics, 458(1). pp. 33-39. (doi:10.1016/j.abb.2006.05.005)

Vokurkova, M., Xu, S., and Touyz, R.M. (2007) Reactive oxygen species, cell growth, cell cycle progression and vascular remodeling in hypertension. Future Cardiology, 3(1). pp. 53-63. (doi:10.2217/14796678.3.1.53)

Ciuceis, C., Amiri, F., Iglarz, M., Cohn, J.S., Touyz, R.M., and Schiffrin, E.L. (2007) Synergistic vascular protective effects of combined low doses of PPARα and PPARγ activators in angiotensin II-induced hypertension in rats. British Journal of Pharmacology, 151(1). pp. 45-53. (doi:10.1038/sj.bjp.0707215)

Ebrahimian, T., He, Y., Schiffrin, E.L., and Touyz, R.M. (2007) Differential regulation of thioredoxin and NAD(P)H oxidase by Angiotensin II in male and female mice. Journal of Hypertension, 25(6). pp. 1263-1271. (doi:10.1097/HJH.0b013e3280acac60)

Fox, C.H., Timm, E.A., Smith, S.J., Touyz, R.M., Bush, E.G., and Wallace, P.K. (2007) A method for measuring intracellular free magnesium concentration in platelets using flow cytometry. Magnesium Research, 20(3). pp. 200-207.

Graham, D. et al. (2007) Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat - Congenic analysis. Hypertension, 50(6). pp. 1134-1141. (doi:10.1161/HYPERTENSIONAHA.107.095349)

Javeshghani, D., Sairam, M.R., Schiffrin, E.L., and Touyz, R.M. (2007) Increased blood pressure, vascular inflammation, and endothelial dysfunction in androgen-deficient follitropin receptor knockout male mice. Journal of the American Society of Hypertension , 1(5). pp. 353-361. (doi:10.1016/j.jash.2007.06.003)

Montezano, A.C., Amiri, F., Tostes, R.C., Touyz, R.M., and Schiffrin, E.L. (2007) Inhibitory effects of PPAR-γ on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Journal of the American Society of Hypertension , 1(2). pp. 150-160. (doi:10.1016/j.jash.2007.01.005)

Sampaio, W.O., Souza dos Santos, R.A., Faria-Silva, R., da Mata Machado, L.T., Schiffrin, E.L., and Touyz, R.M. (2007) Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via akt-dependent pathways. Hypertension, 49(1). pp. 185-192.

Savoia, C., Touyz, R.M., Volpe, M., and Schiffrin, E.L. (2007) Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients. Hypertension, 49(2). pp. 341-346. (doi:10.1161/01.HYP.0000253968.95136.b8)

Touyz, R.M. (2007) Regulation of endothelial nitric oxide synthase by throbin. Hypertension, 49(3). pp. 429-431. (doi:10.1161/01.HYP.0000255955.75119.1a)

Touyz, R.M. (2007) Vascular remodeling, retinal arteries, and hypertension. Hypertension, 50(4). pp. 603-604. (doi:10.1161/HYPERTENSIONAHA.107.095638)

Touyz, R.M., Savoia, C., He, Y., Endemann, D., Pu, Q., Ko, E.A., DeCiuceis, C., Montezano, A.C., and Schiffrin, E.L. (2007) Increased inflammatory biomarkers in hypertensive type 2 diabetic patients: improvement after angiotensin II type 1 receptor blockade. Journal of the American Society of Hypertension , 1(3). pp. 189-199. (doi:10.1016/j.jash.2007.01.009)

White, M. et al. (2007) Effects of combined candesartan and ACE inhibitors on BNP, markers of inflammation and oxidative stress, and glucose regulation in patients with symptomatic heart failure. Journal of Cardiac Failure, 13(2). pp. 86-94. (doi:10.1016/j.cardfail.2006.10.013)

Yogi, A., Callera, G.E., Montezano, A.C., Aranha, A.B., Tostes, R.C., Schiffrin, E.L., and Touyz, R.M. (2007) Endothelin-1, but not Ang II, activates MAP kinases through c-Src-independent Ras-Raf-dependent pathways in vascular smooth muscle cells. Arteriosclerosis, Thrombosis and Vascular Biology, 27(9). pp. 1960-1967. (doi:10.1161/ATVBAHA.107.146746)

Zargham, R., Touyz, R.M., and Thibault, G. (2007) α8 integrin overexpression in de-differentiated vascular smooth muscle cells attenuates migratory activity and restores the characteristics of the differentiated phenotype. Atherosclerosis, 195(2). pp. 303-312. (doi:10.1016/j.atherosclerosis.2007.01.005)

da Costa Goncalves, A.C. et al. (2007) Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function. American Journal of Physiology: Heart and Circulatory Physiology, 293(4). H2588-H2596. (doi:10.1152/ajpheart.00173.2007)

Touyz, R.M., and Schiffrin, E.L. (2006) Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications. Vascular Pharmacology, 45(1). pp. 19-28. (doi:10.1016/j.vph.2005.11.014)

Touyz, R.M. (2006) Magnesium and hypertension. Current Opinion in Nephrology and Hypertension, 15(2). pp. 141-144. (doi:10.1097/01.mnh.0000214773.34480.d4)

Callera, G.E., Tostes, R.C., Yogi, A., Montezano, A.C., and Touyz, R.M. (2006) Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms. Clinical Science, 110(2). pp. 243-253. (doi:10.1042/CS20050307)

Ducharme, A. et al. (2006) Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support. Clinical Science, 110(4). pp. 483-489. (doi:10.1042/CS20050317)

Javeshghani, D., Sairam, M.R., Neves, M.F., Schiffrin, E.L., and Touyz, R.M. (2006) Angiotensin II induces vascular dysfunction without exacerbating blood pressure elevation in a mouse model of menopause-associated hypertension. Journal of Hypertension, 24(7). pp. 1365-1373. (doi:10.1097/01.hjh.0000234117.25401.f8)

Ko, E.A., Amiri, F., Pandey, N.R., Javeshghani, D., Leibovitz, E., Touyz, R.M., and Schiffrin, E.L. (2006) Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice. American Journal of Physiology: Heart and Circulatory Physiology, 292(4). H1789-H1795. (doi:10.1152/ajpheart.01118.2006)

Paravicini, T.M., and Touyz, R.M. (2006) Redox signaling in hypertension. Cardiovascular Research, 71(2). pp. 247-258. (doi:10.1016/j.cardiores.2006.05.001)

Savoia, C., Ebrahimian, T., He, Y., Gratton, J., Schiffrin, E.L., and Touyz, R.M. (2006) Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase. Journal of Hypertension, 24(12). pp. 2417-2422. (doi:10.1097/01.hjh.0000251902.85675.7e)

Savoia, C., Touyz, R.M., Endemann, D., Pu, Q., Ko, E.A., De Ciuceis, C., and Schriffin, E.L. (2006) Angiotensin receptor blocker added to previous antihypertensive agents on arteries of diabetic hypertensive patients. Hypertension, 48(2). pp. 271-277. (doi:10.1161/01.HYP.0000230234.84356.36)

Touyz, R.M. (2006) Lipid rafts take center stage in endothelial cell redox signaling by death receptors. Hypertension, 47(1). pp. 16-18. (doi:10.1161/01.HYP.0000196730.13216.f3)

Touyz, R.M. (2006) Mitochondrial redox control of matrix metalloproteinase signaling in resistance arteries. Arteriosclerosis, Thrombosis and Vascular Biology, 26(4). pp. 685-688. (doi:10.1161/01.ATV.0000216428.90962.60)

Touyz, R.M., He, Y., Montezano, A.C., Yao, G., Chubanov, V., Gudermann, T., and Callera, G.E. (2006) Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats. AJP: Regulatory, Integrative and Comparative Physiology, 290(1). R73-R78. (doi:10.1152/ajpregu.00515.2005)

Xu , S., and Touyz, R.M. (2006) Reactive oxygen species and vascular remodeling in hypertension: still alive. Canadian Journal of Cardiology, 22(11). pp. 947-951.

Tabet, F., Schiffrin, E.L., and Touyz, R.M. (2005) Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: upregulation in spontaneously hypertensive rats. Journal of Hypertension, 23(11). pp. 2005-2012.

Santos, R.A.,, Ferreira, A.J., Pinheiro, S.V.B., Sampaio, W.O., Touyz, R.M., and Campagnole-Santos, M.J. (2005) Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs. Expert Opinion on Investigational Drugs, 14(8). pp. 1019-1031. (doi:10.1517/13543784.14.8.1019)

Touyz, R. (2005) Intracellular mechanisms involved in vascular remodeling of resistance arteries in hypertension: role of angiotensin II. Experimental Physiology, 90(4). pp. 449-455. (doi:10.1113/expphysiol.2005.030080)

Khan, N.A. et al. (2005) The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: part II - therapy. Canadian Journal of Cardiology, 21(8). pp. 657-672.

Savoia, C., Tabet, F., Yao, G., Schiffrin, E.L., and Touyz, R.M. (2005) Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats. Journal of Hypertension, 23(5). pp. 1037-1045.

Beaucage, P., Iglarz, M., Servant, M., Touyz, R.M., and Moreau, P. (2005) Position of Src tyrosine kinases in the interaction between angiotensin II and endothelin in in vivo vascular protein synthesis. Journal of Hypertension, 23(2). pp. 329-335.

Callera, G. E., Montezano, A.C., Alvaro, Y., Tostes, R.C., He, Y., Schriffin, E., and Touyz, R.M. (2005) c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension, 46(4). pp. 1032-1038. (doi:10.1161/01.HYP.0000176588.51027.35)

Callera, G.E., Touyz, R.M., Tostes, R.C., Yogi, A., He, Y., Malkinson, S., and Schriffin, E.L. (2005) Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src. Hypertension, 45(4). pp. 773-779. (doi:10.1161/01.HYP.0000154365.30593.d3)

Cruzado, M., Risler, N., Miatello, R., Yao, G., Schriffin, E., and Touyz, R.M. (2005) Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: Effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation. American Journal of Hypertension, 18(1). pp. 81-87. (doi:10.1016/j.amjhyper.2004.09.001)

De Ciuceis, C., Amiri, F., Brassard, P., Endemann, D.H., Touyz, R.M., and Schriffin, E.L. (2005) Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of Angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in Angiotensin-induced vascular injury. Arteriosclerosis, Thrombosis and Vascular Biology, 25(10). pp. 2106-2113. (doi:10.1161/01.ATV.0000181743.28028.57)

He, Y., Yao, G., Savoia, C., and Touyz, R.M. (2005) Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of Angiotensin II. Circulation Research, 96(2). pp. 207-215. (doi:10.1161/01.RES.0000152967.88472.3e)

Jamnik, V.K., Gledhill, N., Touyz, R.M., Campbell, N.R.C., Logan, A.G., Padwal, R., and Petrella, R. (2005) Lifestyle modifications to prevent and manage hypertension for exercise physiologists and fitness professionals. Canadian Journal of Applied Physiology, 30(6). pp. 754-761. (doi:10.1139/h05-154)

Padwal, R., Campbell, N.R.C., and Touyz, R.M. (2005) Applying the 2005 Canadian Hypertension Education Program recommendations: 3. Lifestyle modifications to prevent and treat hypertension. Canadian Medical Association Journal, 173(7). pp. 749-751. (doi:10.1503/cmaj.050186)

Schiffrin, E.L., and Touyz, R.M. (2005) Calcium, magnesium, and oxidative stress in hyperaldosteronism. Circulation, 111(7). pp. 830-831. (doi:10.1161/01.CIR.0000157186.95918.78)

Touyz, R.M. (2005) Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase. Hypertension, 45(4). pp. 530-537. (doi:10.1161/01.HYP.0000158845.49943.5e)

Touyz, R.M. (2005) Endothelial cell IL-8, a new target for Adiponectin: implications in vascular protection. Circulation Research, 97(12). pp. 1216-1219. (doi:10.1161/01.RES.0000196745.09234.36)

Touyz, R.M. (2005) Molecular and cellular mechanisms in vascular injury in hypertension: role of angiotensin II [editorial review]. Current Opinion in Nephrology and Hypertension, 14(2). pp. 125-131.

Touyz, R.M., Yao, G., Quinn, M.T., Pagano, P.J., and Schriffin, E.L. (2005) p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by Angiotensin II. Arteriosclerosis, Thrombosis and Vascular Biology, 25(3). pp. 512-518. (doi:10.1161/01.ATV.0000154141.66879.98)

Touyz, R.M., Yao, G., and Schiffrin, E.L. (2005) Role of the actin cytoskeleton in angiotensin II signaling in human vascular smooth muscle cells. Canadian Journal of Physiology and Pharmacology, 83(1). pp. 91-97. (doi:10.1139/y05-006)

Touyz, R.M., Yao, G., Viel, E., Amiri, F., and Schiffrin, E.L. (2004) Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells. Journal of Hypertension, 22(6). pp. 1141-1149.

Touyz, R.M., Campbell, N., Logan, A., Gledhill, N., Petrella, R., and Padwal, R. (2004) The 2004 Canadian recommendations for the management of hypertension: Part III--Lifestyle modifications to prevent and control hypertension. Canadian Journal of Cardiology, 20(1). pp. 55-59.

Amiri, F., Virdis, A.,, Neves, M.F., Iglarz, M., Seidah, N.G., Touyz, R.M., Reudelhuber, T.L., and Schiffrin, E.L. (2004) Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation, 110(15). pp. 2233-2240. (doi:10.1161/01.CIR.0000144462.08345.B9)

Callera, G.E., Montezano, A.C., Touyz, R.M., Zorn, T.M.T., Carvalho, M.H., Fortes, Z.B., Nigro, D., Schriffin, E.L., and Tostes, R.C. (2004) ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats. Hypertension, 43(4). pp. 872-879. (doi:10.1161/01.HYP.0000117296.30296.14)

Daigle, C., Martens, F.M.A.C., Girardot, D., Dao, H., Touyz, R.M., and Moreau, P. (2004) Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo. BMC Cardiovascular Disorders, 4(6). (doi:10.1186/1471-2261-4-6)

Endemann, D.H., Pu, Q., De Ciuceis, C., Savoia, C., Virdis, A., Neves, M.F., Touyz, R.M., and Schriffin, E.L. (2004) Persistent remodeling of resistance arteries in type 2 diabetic patients on antihypertensive treatment. Hypertension, 43(2). pp. 399-404. (doi:10.1161/01.HYP.0000112029.03691.e7)

Endemann, D.H., Touyz, R.M., Iglarz, M., Savoia, C., and Schiffrin, E.L. (2004) Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension, 43(6). pp. 1252-1257. (doi:10.1161/01.HYP.0000128031.31572.a3)

Iglarz, M., Touyz, R.M., Viel, E.C., Amiri, F., and Schiffrin, E.L. (2004) Involvement of oxidative stress in the profibrotic action of aldosterone: interaction with the renin-angiotensin system. American Journal of Hypertension, 17(7). pp. 597-603. (doi:10.1016/j.amjhyper.2004.04.005)

Lochard, N., Thibault, G., Silversides, D.W., Touyz, R.M., and Reudelhuber, T.L. (2004) Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist. Circulation Research, 94(11). pp. 1451-1457. (doi:10.1161/01.RES.0000130654.56599.40)

Mabrouk, M.E., Diep, Q.N., Benkirane, K., Touyz, R.M., and Schriffin, E.L. (2004) SAM68: a downstream target of angiotensin II signaling in vascular smooth muscle cells in genetic hypertension. American Journal of Physiology: Heart and Circulatory Physiology, 286(5). H1954-H1962. (doi:10.1152/ajpheart.00134.2003)

Tabet, F., Savoia, C., Schiffrin, E.L., and Touyz, R.M. (2004) Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 44(2). pp. 200-208. (doi:10.1097/00005344-200408000-00009)

Touyz, R.M. (2004) Magnesium in clinical medicine. Frontiers in Bioscience, 9. pp. 1278-1293.

Touyz, R.M. (2004) Reactive oxygen species and angiotensin II signaling in vascular cells – implications in cardiovascular disease. Brazilian Journal of Medical and Biological Research, 37(8). pp. 1263-1273.

Touyz, R.M. (2004) Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension, 44(3). pp. 248-252. (doi:10.1161/01.HYP.0000138070.47616.9d)

Touyz, R.M., and Schiffren, E.L. (2004) Reactive oxygen species in vascular biology: implications in hypertension. Histochemistry and Cell Biology, 122. pp. 339-352.

Virdis, A., Neves, M.F., Amiri, F., Touyz, R.M., and Schiffrin, E.L. (2004) Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice. Journal of Hypertension, 22(3). pp. 535-542.

Touyz, R.M., and Yao, G. (2003) Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger. Clinical Science, 105(2). pp. 235-242.

Touyz, R.M. (2003) The role of angiotensin II in regulating vascular structural and functional changes in hypertension. Current Hypertension Reports, 5(2). pp. 155-164. (doi:10.1007/s11906-003-0073-2)

Callera, G.E., Touyz, R.M., Teixeira, S.A., Muscara, M.N., Carvalho, M.H., Fortes, Z.B., Nigro, D.N., Schiffrin, E.L., and Tostes, R.C. (2003) ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension. Hypertension, 42(4). pp. 811-817. (doi:10.1161/01.HYP.0000088363.65943.6C)

Iglarz, M., Touyz, R.M., Amiri, F., Lavoie, M.F., Diep, Q.N., and Schriffin, E.L. (2003) Effect of peroxisome proliferator-activated receptor-α and -γ activators on vascular remodeling in endothelin-dependent hypertension. Arteriosclerosis, Thrombosis and Vascular Biology, 23(1). pp. 45-51. (doi:10.1161/01.ATV.0000047447.67827.CD)

Iglarz, M., Touyz, R.M., Viel, E.C., Paradis, P., Amiri, F., Diep, Q.N., and Schiffrin, E.L. (2003) Peroxisome proliferator-activated receptor-α and receptor-γ activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension. Hypertension, 42(4). pp. 737-743. (doi:10.1161/01.HYP.0000083511.91817.B1)

Javeshghani, D., Touyz, R.M., Sairam, M.R., Virdis, A., Neves, M.F., and Schiffrin, E.L. (2003) Attenuated responses to angiotensin II in follitropin receptor knockout mice, a model of menopause-associated hypertension. Hypertension, 42(4). pp. 761-767. (doi:10.1161/01.HYP.0000085331.22169.3F)

Pu, Q., Neves, M.F., Virdis, A., Touyz, R.M., and Schriffin, E.L. (2003) Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension, 42(1). pp. 49-55. (doi:10.1161/01.HYP.0000078357.92682.EC)

Schiffrin, E.L., and Touyz, R.M. (2003) Inflammation and vascular hypertrophy induced by angiotensin II: role of NADPH oxidase-derived reactive oxygen species independently of blood pressure elevation? Arteriosclerosis, Thrombosis and Vascular Biology, 23(5). pp. 707-709. (doi:10.1161/01.ATV.0000069907.12357.7E)

Schiffrin, E.L., and Touyz, R.M. (2003) Multiple actions of angiotensin II in hypertension. Journal of the American College of Cardiology, 42(5). pp. 911-913. (doi:10.1016/S0735-1097(03)00845-3)

Touyz, R.M. (2003) Activated oxygen metabolites: do they really play a role in angiotensin II-regulated vascular tone? Journal of Hypertension, 21(12). pp. 2235-2238.

Touyz, R.M. (2003) Pressure-induced expression of vascular neuronal nitric oxide synthase: adaptive or maladaptive response in arteries? Journal of Hypertension, 21(5). pp. 863-865.

Touyz, R.M. (2003) Reactive oxygen species in vascular biology: Role in arterial hypertension. Expert Review of Cardiovascular Therapy, 1(1). pp. 91-106.

Touyz, R.M. (2003) Recent advances in intracellular signaling in hypertension. Current Opinion in Nephrology and Hypertension, 12(2). pp. 165-174.

Touyz, R.M., Cruzado, M., Tabet, F., Yao, G., Salomon, S., and Schiffrin, E.L. (2003) Redox-dependent MAP kinase signaling by Ang II in vascular smooth muscle cells: role of receptor tyrosine kinase transactivation. Canadian Journal of Physiology and Pharmacology, 81(2). pp. 159-167. (doi:10.1139/y02-164)

Touyz, R.M., Tabet, F., and Schiffrin, E.L. (2003) Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension. Clinical and Experimental Pharmacology and Physiology, 30(11). pp. 860-866. (doi:10.1046/j.1440-1681.2003.03930.x)

Touyz, R.M., and Yao, G. (2003) Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats. Journal of Hypertension, 21(2). pp. 337-344.

Touyz, R.M., and Yao, G. (2003) Modulation of vascular smooth muscle cell growth by magnesium-role of mitogen-activated protein kinases. Journal of Cellular Physiology, 197(3). pp. 326-335. (doi:10.1002/jcp.10393)

Touyz, R.M., Yao, G., and Schriffin, E.L. (2003) c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells. Arteriosclerosis, Thrombosis and Vascular Biology, 23(6). pp. 981-987. (doi:10.1161/01.ATV.0000069236.27911.68)

Virdis, A., Iglarz, M., Neves, M.F., Amiri, F., Touyz, R.M., Rozen, R., and Schriffin, E.L. (2003) Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice. Arteriosclerosis, Thrombosis and Vascular Biology, 23(8). pp. 1352-1357. (doi:10.1161/01.ATV.0000083297.47245.DA)

Tostes, R.C.A., Touyz, R.M., He, G., Chen, X., and Schiffrin, E.L. (2002) Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension. Clinical Science, 103(Sup 48). 25S-30S.

Endemann, D., Touyz, R.M., Yoa, G., and Schiffrin, E.L. (2002) Tyrosine kinase inhibition attenuates vasopressin-induced contraction of mesenteric resistance arteries: alterations in spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 40(1). pp. 123-132.

Touyz, R.M., Deschepper, C., Park, J.B., He, G., Chen, X., Neves, M.F.T., Virdis, A., and Schiffrin, E.L. (2002) Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats. Journal of Hypertension, 20(6). pp. 1127-1134. (doi:10.1097/00004872-200206000-00024)

Zarnke, K.B. et al. (2002) The 2001 Canadian recommendations for the management of hypertension: Part one--Assessment for diagnosis, cardiovascular risk, causes and lifestyle modification. Canadian Journal of Cardiology, 18(6). pp. 604-624.

Pu, Q., Touyz, R.M., and Schiffrin, E.L. (2002) Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats. Journal of Hypertension, 20(5). pp. 899-907. (doi:10.1097/00004872-200205000-00025)

Touyz, R.M. (2002) Impaired vasorelaxation in hypertension: beyond the endothelium. Journal of Hypertension, 20(3). pp. 371-373. (doi:10.1097/00004872-200203000-00007)

Deschepper, C.F., Picard, S., Thibault, G., Touyz, R.M., and Rouleau, J. (2002) Characterization of myocardium, isolated cardiomyocytes, and blood pressure in WKHA and WKY rats. American Journal of Physiology: Heart and Circulatory Physiology, 282(1). H149-H155. (doi:10.​1152/​ajpheart.​00672.​2001)

Berry, C., and Touyz, R.M. (2002) Recent advances in angiotensin II signaling. Brazilian Journal of Medical and Biological Research, 35(9). pp. 1001-1015.

Diep, Q.N., Amiri, F., Touyz, R.M., Cohn, J.S., Endemann, D., Neves, M.F., and Schriffin, E.L. (2002) PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation. Hypertension, 40(6). pp. 866-871. (doi:10.1161/01.HYP.0000037969.41360.CC)

Park, J.B., Touyz, R.M., Chen, X., and Schriffin, E.L. (2002) Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats. American Journal of Hypertension, 15(1). pp. 78-84. (doi:10.1016/S0895-7061(01)02233-6)

Tostes, R.C.A., Touyz, R.M., He, G., Ammarguellat, F., and Schiffrin, E.L. (2002) Endothelin a receptor blockade decreases expression of growth factors and collagen and improves matrix metalloproteinase-2 activity in kidneys from stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 39(6). pp. 892-900. (doi:10.1097/00005344-200206000-00015)

Touyz, R.M., Chen, X., Tabet, F., Yao, G., He, G., Quinn, M., Pagano, P.J., and Schriffin, E.L. (2002) Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II. Circulation Research, 90(11). pp. 1205-1213. (doi:10.1161/01.RES.0000020404.01971.2F)

Touyz, R.M., Pu, Q., He, G., Chen, X., Yao, G., Neves, M.F., and Viel, E. (2002) Effects of low dietary magnesium intake on development of hypertension in stroke-prone spontaneously hypertensive rats. Journal of Hypertension, 20(11). pp. 2221-2232. (doi:10.1097/00004872-200211000-00022)

Touyz, R.M., Wu, X.H., He, G., Steven, S., and Schriffin, E.L. (2002) Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased c-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats. Hypertension, 39(2). pp. 479-485. (doi:10.1161/hy02t2.102909)

Virdis, A., Neves, M.F., Amiri, F., Viel, E., Touyz, R.M., and Schriffin, E.L. (2002) Spironolactone improves Angiotensin-induced vascular changes and oxidative stress. Hypertension, 40(4). pp. 504-510. (doi:10.1161/01.HYP.0000034738.79310.06)

El Mabrouk, M., Touyz, R.M., and Schiffrin, E.L. (2001) Differential ANG II-induced growth activation pathways in mesenteric artery smooth muscle cells from SHR. American Journal of Physiology: Heart and Circulatory Physiology, 281(1). H30-H39.

Diep, Q.N., El Mabrouk, M., Touyz, R.M., and Schiffrin, E.L. (2001) Expression of cell cycle proteins in blood vessels of angiotensin II-inused rats: role of AT(1) receptors. Hypertension, 37(Part 2). pp. 604-608.

Berry, C., Touyz, R., Dominiczak, A.F., Webb, R.C., and Johns, D.G. (2001) Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. American Journal of Physiology: Heart and Circulatory Physiology, 281(6). H2337-H2365.

Chen, X., Touyz, R.M., Park, J.B., and Schiffrin, E.L. (2001) Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. Hypertension, 38(3). pp. 606-611. (doi:10.1161/hy09t1.094005)

McAlister, F.A. et al. (2001) The 2000 Canadian recommendations for the management of hypertension: Part one--therapy. Canadian Journal of Cardiology, 17(5). pp. 543-559.

Touyz, R.M., He, G., El Mabrouk, M., Diep, Q., Mardigyan, V., and Schiffrin, E.L. (2001) Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar–Kyoto rats and spontaneously hypertensive rats. Journal of Hypertension, 19(3 Supp). pp. 553-559. (doi:10.1097/00004872-200103001-00006)

Touyz, R.M., He, G., El Mabrouk, M., and Schiffrin, E.L. (2001) p38 Map kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY. Hypertension, 37(Part 2). pp. 574-580.

Touyz, R.M., He, G., Wu, X.H., Park, J.B., Mabrouk, M.E., and Schiffrin, E.L. (2001) Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients. Hypertension, 38(1). pp. 56-64.

Touyz, R.M., Mercure, C., and Reudelhuber, T.L. (2001) Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms. Journal of Biological Chemistry, 276(17). pp. 13657-13663. (doi:10.1074/jbc.M008101200)

Touyz, R.M., and Schiffrin, E.L. (2001) Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways. Journal of Hypertension, 19(7). pp. 1245-1254. (doi:10.1097/00004872-200107000-00009)

Touyz, R.M., Wu, X., He, G., Park, J.B., Chen, X., Vacher, J., Rajapurohitam, V., and Schiffrin, E.L. (2001) Role of c-Src in the regulation of vascular contraction and Ca2+ signaling by angiotensin II in human vascular smooth muscle cells. Journal of Hypertension, 19(3). pp. 441-449. (doi:10.1097/00004872-200103000-00012)

Touyz, R.M., and Schiffren, E.L. (2000) Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacological Reviews, 52(4). pp. 639-672.

Diep, Q.N., Touyz, R.M., and Schiffrin, E.L. (2000) Docosahexaenoic acid, a peroxisome proliferator-activated receptor- ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension, 36(5). pp. 851-855. (doi:10.1161/01.HYP.36.5.851)

Touyz, R.M., Turgeon, A., and Schiffrin, E.L. (2000) Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 36(Sup 1). S300-S304.

Touyz, R.M. (2000) Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertension. Journal of Hypertension, 18(9). pp. 1177-1191.

El Mabrouk, M., Singh, A., Touyz, R.M., and Schiffrin, E.L. (2000) Antiproliferative effect of L-NAME on rat vascular smooth muscle cells. Life Sciences, 67(13). pp. 1613-1623. (doi:10.1016/S0024-3205(00)00744-X)

Tea, B.-S., Der Sarkissian, S., Touyz, R.M., Hamet, P., and deBlois, D. (2000) Proapoptotic and growth-inhibitory role of angiotensin II type 2 receptor in vascular smooth muscle cells of spontaneously hypertensive rats in vivo. Hypertension, 35(5). pp. 1069-1073. (doi:10.1161/01.HYP.35.5.1069)

Schiffrin, E.L., Park, J.B., Intengan, H.D., and Touyz, R.M. (2000) Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan. Circulation, 101(14). pp. 1653-1659. (doi:10.1161/01.CIR.101.14.1653)

Touyz, R.M., Jiang, L., and Sairiam, M.R. (2000) Follicle-stimulating hormone mediated calcium signaling by the alternatively spliced growth factor type I receptor. Biology of Reproduction, 62(4). pp. 1067-1074. (doi:10.1095/biolreprod62.4.1067)

Fareh, J., Touyz, R.M., Schiffrin, E.L., and Thibault, G. (2000) Altered cardiac endothelin receptors and protein kinase C in deoxycorticosterone-salt hypertensive rats. Journal of Molecular and Cellular Cardiology, 32(4). pp. 665-676. (doi:10.1006/jmcc.2000.1110)

Touyz, R.M. (2000) Oxidative stress and vascular damage in hypertension. Current Hypertension Reports, 2(1). pp. 98-105. (doi:10.1007/s11906-000-0066-3)

Touyz, R.M. (2000) Molecular and cellular mechanisms regulating vascular function and structure--implications in the pathogenesis of hypertension. Canadian Journal of Cardiology, 16(9). pp. 1137-1146.

Touyz, R.M., and Schiffrin, E.L. (1999) Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells. Hypertension, 34(4). pp. 976-982. (doi:10.1161/01.HYP.34.4.976)

Touyz, R.M., and Schiffrin, E.L. (1999) Activation of the Na+-H+ exchanger modulates angiotensin II stimulated Na+-dependent Mg2+ transport in vascular smooth muscle cells in genetic hypertension. Hypertension, 34(3). pp. 442-449. (doi:10.1161/01.HYP.34.3.442)

Touyz, R.M., and Milne, F.J. (1999) Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats. American Journal of Hypertension, 12(8). pp. 757-765. (doi:10.1016/S0895-7061(99)00064-3)

Babu, P.S., Jiang, L., Sairam, A.M., Touyz, R.M., and Sairam, M.R. (1999) Structural features and expression of an alternatively spliced growth factor type I receptor for follitropin signaling in the developing ovary. Molecular Cell Biology Research Communications, 2(1). pp. 21-27. (doi:10.1006/mcbr.1999.0139)

Endemann, D., Touyz, R.M., Li, J.-S., and Schiffrin, E.L. (1999) Altered angiotensin II-induced small artery contraction during the development of hypertension in spontaneously hypertensive rats. American Journal of Hypertension, 12(7). pp. 716-723. (doi:10.1016/S0895-7061(99)00036-9)

Touyz, R.M., Deng, L.-Y., He, G., Wu, X.-H., and Schiffrin, E.L. (1999) Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: role of extracellular signal-regulated kinases. Journal of Hypertension, 17(7). pp. 907-916.

Touyz, R.M., El Mabrouk, M., He, G., Wu, X.-H., and Schiffrin, E.L. (1999) Mitogen-activated protein/extracellular signal regulated kinase inhibition attenuates angiotensin II mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells. Circulation Research, 84(5). pp. 505-515. (doi:10.1161/01.RES.84.5.505)

Touyz, R.M., He, G., Deng, L.-Y., and Schiffrin, E.L. (1999) Role of extracellular signal-regulated kinases in angiotensin II stimulated contraction of smooth muscle cells from human resistance arteries. Circulation, 99(3). pp. 392-399. (doi:10.1161/01.CIR.99.3.392)

Touyz, R.M., Endemann, D., He, G., Li, J.-S., and Schiffrin, E.L. (1999) Role of AT2 receptors in angiotensin II stimulated contraction of small mesenteric arteries in young SHR. Hypertension, 33(1). pp. 366-372. (doi:10.1161/01.HYP.33.1.366)

Schiffrin, E. L., and Touyz, R.M. (1999) Role of endothelin-1 in hypertension. Hypertension, 34(4). pp. 876-881. (doi:10.1161/01.HYP.34.4.876)

Touyz, R.M., Laurant, P., and Schiffrin, E.L. (1998) Effect of magnesium on calcium responses to vasopressin in vascular smooth muscle cells of spontaneously hypertensive rats. Journal of Pharmacology and Experimental Therapeutics, 284(3). pp. 998-1005.

Li, J.S., Touyz, R.M., and Schiffrin, E.L. (1998) Effects of AT1 and AT2 angiotensin receptor antagonists in angiotensin II-infused rats. Hypertension, 31(1). pp. 487-492. (doi:10.1161/01.HYP.31.1.487)

Schiffrin, E.L., and Touyz, R.M. (1998) Vascular biology of endothelin. Journal of Cardiovascular Pharmacology, 32(Sup 3). S2-S13.

Sharifi, A.M., He, G., Touyz, R.M., and Schiffrin, E.L. (1998) Vascular endothelin-1 expression and effect of an endothelin ETA antagonist on structure and function of small arteries from stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 31(Sup 1). S309-S312.

Touyz, R.M., Fareh, J., Thibault, G., and Schiffrin, E.L. (1998) Endothelin-1 signaling is altered in cardiac cells from deoxycorticosterone acetate-salt hypertensive rats. Journal of Cardiovascular Pharmacology, 31(Sup 1). S179-S181. (doi:10.1097/00005344-199800001-00051)

Touyz, R.M., and Schiffrin, E.L. (1997) Growth factors mediate intracellular signaling in vascular smooth muscle cells through protein kinase C-linked pathways. Hypertension, 30(6). pp. 1440-1447. (doi:10.1161/01.HYP.30.6.1440)

Touyz, R.M., and Schiffrin, E.L. (1997) Role of calcium influx and intracellular calcium stores in angiotensin II-mediated calcium hyper-responsiveness in smooth muscle from spontaneously hypertensive rats. Journal of Hypertension, 15(2). pp. 1431-1439.

Fareh, J., Touyz, R.M., Schiffrin, E.L., and Thibault, G. (1997) Cardiac type-1 angiotensin II receptor status in deoxycorticosterone acetate salt hypertension in rats. Hypertension, 30(5). pp. 1253-1259. (doi:10.1161/01.HYP.30.5.1253)

Lacroix, A., Tremblay, J., Touyz, R.M., Deng, L.Y., Lariviere, R., Cusson, J.R., Schiffrin, E.L., and Hamet, P. (1997) Abnormal adrenal and vascular responses to vasopressin mediated by a v1-vasopressin receptor in a patient with adrenocorticotropin-independent macronodular adrenal hyperplasia, cushing's syndrome, and orthostatic hypotension. Journal of Clinical Endocrinology and Metabolism, 82(8). pp. 2414-2422. (doi:10.1210/jc.82.8.2414)

Touyz, R.M., and Schiffrin, E.L. (1997) Angiotensin II regulates vascular smooth muscle cell ph, contraction, and growth via tyrosine kinase dependent signaling pathways. Hypertension, 30(2). pp. 222-229. (doi:10.1161/01.HYP.30.2.222)

Touyz, R.M., and Schiffrin, E.L. (1997) Reply to letter by S. Bund regarding 'differential effects of vasopressin and endothelin-1 on vascular contractile and calcium responses in pressurized small arteries from SHR. Journal of Hypertension, 15(8). pp. 912-913.

Methot, D., LaPointe, M.C., Touyz, R.M., Yang, X.-P., Carretero, O.A., Deschepper, C.F., Schiffrin, E.L., and Thibault, G. (1997) Tissue targeting of angiotensin peptides. Journal of Biological Chemistry, 272(20). pp. 12994-12999. (doi:10.1074/jbc.272.20.12994)

Laurant, P., Touyz, R.M., and Schiffrin, E.L. (1997) Effect of magnesium on vascular tone and reactivity in pressurized mesenteric resistance arteries from spontaneously hypertensive rats. Canadian Journal of Physiology and Pharmacology, 75(4). pp. 293-300. (doi:10.1139/y97-044)

Touyz, R.M., Picard, S., Schiffrin, E.L., and Deschepper, C.F. (1997) Cyclic GMP inhibits a pharmacologically distinct Na+/H+ exchanger variant in cultured rat astrocytes via an extracellular site of action. Journal of Neurochemistry, 68(4). pp. 1451-1461. (doi:10.1046/j.1471-4159.1997.68041451.x)

Lawant, P., Touyz, R.M., and Schiffrin, E.L. (1997) Effect of pressurization on mechanical properties of mesenteric small arteries from spontaneously hypertensive rats. Journal of Vascular Research, 34(2). pp. 117-125. (doi:10.1159/000159209)

Schiffrin, E.L., Intengan, H.D., Thibault, G., and Touyz, R.M. (1997) Clinical significance of endothelin in cardiovascular disease. Current Opinion in Cardiology, 12. pp. 354-367.

Touyz, R.M., Fareh, J., Thibault, G., and Schiffrin, E.L. (1996) Intracellular calcium2+ modulation by angiotensin II and endothelin-1 in cardiomyocytes and fibroblasts from hypertrophied hearts of spontaneously hypertensive rats. Hypertension, 28(5). pp. 797-805.

Touyz, R.M., and Schiffrin, E.L. (1996) Angiotensin II and vasopressin modulate intracellular free magnesium in vascular smooth muscle cells through Na+-dependent protein kinase C pathways. Journal of Biological Chemistry, 271(40). pp. 24353-24358. (doi:10.1074/jbc.271.40.24353)

Touyz, R.M., Deng, L.Y., Li, J.S., and Schiffrin, E.L. (1996) Differential effects of vasopressin and endothelin-1 on vascular contractile and calcium responses in pressurized small arteries from spontaneously hypertensive rats. Journal of Hypertension, 14(8). pp. 983-991.

Touyz, R.M., and Schiffrin, E.L. (1996) Tyrosine kinase signaling pathways modulate angiotensin II induced calcium ([Ca2+]i) transients in vascular smooth muscle cells. Hypertension, 27(5). pp. 1097-1103. (doi:10.1161/01.HYP.27.5.1097)

Touyz, R.M., Sventek, P., Lariviere, R., Thibault, G., Fareh, J., Reudelhuber, T., and Schiffrin, E.L. (1996) Cytosolic calcium changes induced by angiotensin II in neonatal rat atrial and ventricular cardiomyocytes are mediated via angiotensin II subtype 1 receptors. Hypertension, 27(5). pp. 1090-1096. (doi:10.1161/01.HYP.27.5.1090)

Touyz, R.M., Fareh, J., Thibault, G., Tolloczko, B., Larivière, R., and Schiffrin, E.L. (1996) Modulation of Ca2+ transients in neonatal and adult rat cardiomyocytes by angiotensin II and endothelin-1. American Journal of Physiology: Heart and Circulatory Physiology, 270(3). H857-H868.

Fareh, J., Touyz, R.M., Schiffrin, E.L., and Thibault, G. (1996) Endothelin-1 and angiotensin II receptors in cells from rat hypertrophied heart: receptor regulation and intracellular Ca2+ modulation. Circulation Research, 78(2). pp. 302-311. (doi:10.1161/01.RES.78.2.302)

Yang, X.-P., Touyz, R.M., Nguyen, P.V., Li, Y.D., Li, J.-S., and Schiffrin, E.L. (1996) Endothelin-1 and vasopressin signalling in blood vessels of young SHR in comparison to adult SHR. Hypertension Research, 19(2). pp. 121-132. (doi:10.1291/hypres.19.121)

Fareh, J., Touyz, R.M., Thibault, G., and Schiffrin, E.L. (1995) Basal and stimulated angiotensin II-induced cytosolic free calcium in adult rat cardiomyocytes and fibroblasts after volume overload. Hypertension, 26(6.2). pp. 1149-1153. (doi:10.1161/​01.HYP.26.6.1149)

Touyz, R.M., Deng, L.Y., and Schiffrin, E.L. (1995) ETB mediated calcium and contractile responses in mesenteric small arteries from WKY and SHR. Hypertension, 26(6). pp. 1041-1045. (doi:10.1161/​01.HYP.26.6.1041)

Touyz, R.M., and Schiffrin, E.L. (1995) Treatment of non-insulin-dependent diabetic hypertensive patients with Ca2+ channel blockers is associated with increased platelet sensitivity to insulin. American Journal of Hypertension, 8(12). pp. 1214-1221. (doi:10.1016/0895-7061(95)00249-9)

Schiffrin, E.L., Larivière, R., Li, J.S., Sventek, P., and Touyz, R.M. (1995) Endothelin-1 gene expression and vascular hypertrophy in DOCA-salt hypertension compared to spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology, 22(s1). S188-S190. (doi:10.1111/j.1440-1681.1995.tb02875.x)

Schiffrin, E.L., Larivière, R., and Touyz, R.M. (1995) ETA and ETB receptors on vascular smooth muscle cells from mesenteric vessels of SHR. Clinical and Experimental Pharmacology and Physiology, 22(s1). S193-S194. (doi:10.1111/j.1440-1681.1995.tb02877.x)

Touyz, R.M., and Milne, F.J. (1995) Alterations in intracellular cations and cell membrane ATPase activity in patients with malignant hypertension. Journal of Hypertension, 13(8). pp. 867-874.

Touyz, R.M., Larivière, R., and Schiffrin, E.L. (1995) Endothelin influences pHi of human platelets through protein kinase C mediated pathways. Thrombosis Research, 78(1). pp. 55-65. (doi:10.1016/0049-3848(95)00034-8)

Schiffrin, E.L., Larivière, R., Li, J.S., Sventek, P., and Touyz, R.M. (1995) Deoxycorticosterone acetate plus salt induces overexpression of vascular endothelin-1 and severe vascular hypertrophy in spontaneously hypertensive rats. Hypertension, 25(4). pp. 769-773. (doi:10.1161/​01.HYP.25.4.769)

Touyz, R.M., and Schiffrin, E.L. (1995) Role of protein kinase C in the antiaggregatory effects of endothelin-l on human platelets. Clinical Science, 88(3). pp. 277-283. (doi:10.1042/cs0880277)

Touyz, R.M., Tolloczko, B., and Schiffrin, E.L. (1995) Blunted attenuation of angiotensin II-mediated Ca2+ transients by insulin in cultured unpassaged vascular smooth muscle cells from spontaneously hypertensive rats. American Journal of Hypertension, 8(2). pp. 104-112. (doi:10.1016/0895-7061(94)00173-9)

Touyz, R.M., Larivière, R., and Schiffrin, E.L. (1995) Endothelin receptor subtypes in mesenteric vascular smooth muscle cells of spontaneously hypertensive rats. Canadian Journal of Physiology and Pharmacology, 73(9). pp. 1262-1273. (doi:10.1139/y95-178)

Touyz, R.M., Panz, V., and Milne, F.J. (1995) Relations between magnesium, calcium and plasma renin activity in black and white hypertensive patients. Mineral and Electrolyte Metabolism, 21(6). pp. 417-422.

Touyz, R.M., and Schiffrin, E.L. (1994) Blunted inhibition by insulin of agonist-stimulated calcium, pH and aggregatory responses in platelets from hypertensive patients. Journal of Hypertension, 12(11). pp. 1255-1263.

Touyz, R.M., and Schiffrin, E.L. (1994) Insulin-induced Ca2+ transport is altered in vascular smooth muscle cells of SHR. Hypertension, 23(6.2). pp. 931-935. (doi:10.1161/​01.HYP.23.6.931)

Touyz, R.M., Tolloczko, B., and Schiffrin, E.L. (1994) Mesenteric vascular smooth muscle cells from SHR display increased Ca2+ responses to angiotensin II but not to endothelin-1. Journal of Hypertension, 12(6). pp. 663-673.

Touyz, R.M., Tolloczko, B., and Schiffren, E.L. (1994) Insulin attenuates agonist-evoked calcium transients in vascular smooth muscle cells. Hypertension, 23(I). I-23. (doi:10.1161/​01.HYP.23.1_Suppl.I25)

Touyz, R.M., and Schiffrin, E.L. (1993) The effect of angiotensin II on platelet intracellular free magnesium and calcium ionic concentrations in essential hypertension. Journal of Hypertension, 11(5). pp. 551-558.

Touyz, R.M., Milne, F.J., and Reinach, S.G. (1993) Altered calcium binding to erythrocyte membranes in essential hypertension: relation to magnesium. Journal of Human Hypertension, 7(1). pp. 59-64.

Touyz, R.M., and Schiffrin, E.L. (1993) Signal transduction in hypertension: part I. Current Opinion in Nephrology and Hypertension, 2(1). pp. 5-16.

Touyz, R.M., and Schiffrin, E.L. (1993) Signal transduction in hypertension: part II. Current Opinion in Nephrology and Hypertension, 2(1). pp. 17-26.

Touyz, R.M., Milne, F.J., and Reinach, S.G. (1993) Racial differences in cell membrane ATPases and cellular cation content in urban South African normotensive and hypertensive subjects. American Journal of Hypertension, 6(8). pp. 693-700. (doi:10.1093/ajh/6.8.693)

Touyz, R.M., and Schiffrin, E.L. (1993) Biology of blood vessels in hypertension. Cardiology in Review, 1(2). pp. 87-96.

Touyz, R.M., and Schiffrin, E.L. (1993) Effects of angiotensin II and endothelin-1 on platelet aggregation and cytosolic pH and free Ca2+ concentrations in essential hypertension. Hypertension, 22. pp. 853-862. (doi:10.1161/​01.HYP.22.6.853)

Touyz, R.M., Milne, F.J., and Reinach, S.G. (1992) Platelet and erythrocyte Mg2+, Ca2+, Na+, K+ and cell membrane adenosine triphosphatase activity in essential hypertension in blacks. Journal of Hypertension, 10(6). pp. 571-578.

Touyz, R.M., Milne, F.J., and Reinach, S.G. (1992) Intracellular Mg2+, Ca2+, Na+ and K+ in platelets and erythrocytes of essential hypertensive patients: relation to blood pressure. Clinical and Experimental Hypertension, a14(6). pp. 1189-1209. (doi:10.3109/10641969209038200)

Touyz, R.M. (1991) Magnesium supplementation as an adjuvant to synthetic calcium channel antagonists in the treatment of hypertension. Medical Hypotheses, 36(2). pp. 140-141. (doi:10.1016/0306-9877(91)90256-X)

Touyz, R.M., Milne, F.J., and Marshall, P.R. (1991) Altered cations and muscle membrane ATPase activity in deoxycorticosterone acetate-salt spontaneously hypertensive rats. Journal of Hypertension, 9(8). pp. 737-750.

England, M.J., Panz, V.R., Joffe, B.I., Touyz, R.M., Shires, R., and Seftel, H.C. (1990) The effect of magnesium sulphate infusion on circulating catecholamine levels in severe gestational proteinuric hypertension. A report of 8 cases. South African Medical Journal, 78(11). pp. 688-690.

Touyz, R.M., and Milne, F.J. (1990) Some cellular events in hypertension - an overview. Cardiovascular Journal of South Africa, 1(3).

Touyz, R.M., Milne, F.J., and Reinach, S.G. (1990) Twenty-four hour ambulatory blood pressure in therapeutically resistant hypertensive patients. Journal of Human Hypertension, 4(4). pp. 393-396.

Touyz, R.M., Milne, F.J., Soicher, E., Neutel, J., Barlow, C., and Reinach, G.S. (1990) Circadian blood pressure variability in essential and secondary hypertension. Cardiovascular Journal of South Africa, 1(3). pp. 125-132.

Touyz, R.M., Rathakrishnan, S., Reinach, S.G., and Milne, F.J. (1989) Hypertension, alcohol and cations in urban black and coloured South Africans. South African Medical Journal, 75(02). pp. 109-113.

Touyz, R.M., Rathakrishnan, S., Adam, E., Sonnekus, M., Reinach, S.G., and Milne, F.J. (1989) The relationship between magnesium, calcium, sodium, potassium and blood pressure in South African adult males. Magnesium, 8(3-4). pp. 145-153.

Touyz, R.M., Kelly, A., Tollman, S., and Milne, F.J. (1988) An assessment of internships at the teaching hospitals of the University of Witwatersrand. South African Medical Journal, 74(08). pp. 173-177.

Touyz, R.M., Milne, F.J., Seflel, M.C., and Reinach, S.G. (1987) Magnesium, calcium, sodium and potassium status in normotensive and hypertensive Johannesburg residents. South African Medical Journal, 72. pp. 377-381.

Books

Montezano, A.C., and Touyz, R.M. (2012) Reactive Oxygen Species and the Cardiovascular System. Series: Integrated systems physiology. Morgan & Claypool. ISBN 9781615043620

Book Sections

Antunes, T.T., Callera, C., and Touyz, R.M. (2013) Vascular biology of magnesium: implications in cardiovascular disease. In: Watson, R.R., Preedy, V.R. and Zibadi, S. (eds.) Magnesium in Human Health and Disease. Series: Nutrition and health. Humana Press. ISBN 9781627030434

Montezano, A.C., Antunes, T.T., Callera, G.E., and Touyz, R.M. (2013) Magnesium and vessels. In: Kreitsinger, R., Permyakov, E. and Uversky, V. (eds.) Encyclopedia of Metalloproteins. Springer. ISBN 9781461415329

Touyz, R.M., and Montezano, A.C. (2013) Vascular function. In: Rosendorff , C. (ed.) Essential Cardiology: Principles and Practice. Springer. ISBN 9781461467045

Touyz, R.M., and Burger, D. (2012) Biomarkers in hypertension. In: Berbari, A.J. and Mancia, G. (eds.) Special issues in Hypertension. Springer, pp. 237-246. ISBN 9788847026001

Touyz, R.M., and Schiffrin, E.L. (2012) Arterial hypertension. In: Hill, J. and Olson, E.N. (eds.) Muscle: Fundamental Biology and Mechanisms of Disease. Pt. IV. Smooth Muscle. Elsevier, pp. 1301-1311. ISBN 9780123815101

Schiffrin, E.L., and Touyz, R.M. (2011) Oxidative stress in arterial hypertension and atherosclerosis. In: Pantopoulos, K. and Schipper, H. (eds.) Principles of Free Radical Biomedicine. Nova Science.

Touyz, R.M., Chignalia, A., and Sedeek, M. (2009) Reactive oxygen species, oxidative stress and hypertension. In: Shah, A. and Laurindo, F. (eds.) Studies on Cardiovascular Disorders. Series: Oxidative stress in applied basic research and clinical practice . Humana Press. ISBN 9781607616009

Touyz, R.M. (2007) Reactive oxygen species and mediators of oxidative stress. In: Izzo, J.L. (ed.) Hypertension Primer. Lippincott Williams & Wilkins. ISBN 9780781782050

Touyz, R.M., and Schiffrin, E.L. (2007) Angiotensin II and inflammation. In: Carey, R.M. (ed.) Hypertension and Hormone Mechanisms. Series: Contemporary endocrinology. Humana Press. ISBN 9781588294081

Schiffrin, E.L., and Touyz, R.M. (2006) Oxidative stress in hypertension. In: Bourassa, M. and Tardif, J.-C. (eds.) Antioxidants in Cardiovascular Disease. Series: Developments in cardiovascular medicine (233). Springer. ISBN 9780387295527

Touyz, R.M. (2004) Magnesium in clinical medicine. In: Maguire , M.E. (ed.) Encyclopedia of Bioscience. McGraw-Hill.

Touyz, R.M., and Schiffrin, E.L. (2004) Hypertension and oxidant stress. In: Holtzman, J.L. (ed.) Atherosclerosis and Oxidant Stress. Kluwer Academic.

Fox, C.H., Ramsoomair, D., Carter, C., and Touyz, R.M. (2003) Magnesium disorders. In: Encyclopedia of Endocrinology. UNSPECIFIED.

Touyz, R.M. (2003) Reactive oxygen species and other mediators of oxidative stress. In: Izzo, J.L. and Black, H.R. (eds.) Hypertension Primer: the Essentials of High Blood Pressure. Lippincott Williams & Wilkins, pp. 52-55. ISBN 9780781745093

Touyz, R.M. (2003) Role of magnesium in the pathogenesis of hypertension. In: Cittadini, A. and Wolf, F.I. (eds.) Magnesium: From Biochemistry and Cell Physiology to Clinical Implications. Series: Molecular aspects of medicine (24). Elsevier Science, pp. 107-136.

Touyz, R.M. (2001) Magnesium responsiveness to Ang II and ET-1 in vascular smooth muscle cells from spontaneously hypertensive rats. In: Rayssiguier , Y., Mazur , A. and Durlach, J. (eds.) Advances in Magnesium Research: Nutrition and Health. John Libbey: Eastleigh, England, pp. 341-347. ISBN 9780861966097

Touyz, R.M., and Schiffrin, E.L. (2000) Measurement of intracellular free calcium ion concentration in vascular smooth muscle cells using fura-2. In: Wang, D.H. (ed.) Angiotensin Protocols. Series: Methods in molecular medicine (51). Humana Press, pp. 341-353. ISBN 9780896037632 (doi:10.1385/1-59259-087-X:341)

Touyz, R.M., and Schiffrin, E.L. (2000) Measurement of phospholipase D activation in vascular smooth muscle cells. In: Wang, D.H. (ed.) Angiotensin Protocols. Series: Methods in molecular medicine (51). Humana Press, pp. 355-362. ISBN 9780896037632 (doi:10.1385/1-59259-087-X:355)

Touyz, R.M. (1989) Aetiology of hypertension in blacks. In: Milne, F.J. and Sareli, P. (eds.) Hypertension and Rheumatic Heart Disease in Black South Africans. Helm Publishing: Johannesberg, South Africa, pp. 6-9.

Conference Proceedings

Schiffrin, E.L., Larivière, R., Li, J.S., Sventek, P., and Touyz, R.M. (1995) Enhanced expression of endothelin-1 gene may cause blood pressure independent vascular hypertrophy. In: Fourth International Conference on Endothelin, London, UK, 23-26 Apr 1995, S5-S8.

Touyz, R.M., Deng, L.Y., and Schiffrin, E.L. (1995) Ca2+ and contractile responses of resistance vessels of WKY and SHR to endothelin-1. In: Fourth International Conference on Endothelin, London, UK, 23-26 Apr 1995, S193-S196.

Touyz, R.M., Fareh, J., Thibault, G., Larivière, R., and Schiffrin, E.L. (1995) Modulation of Ca2+ transients in neonatal and adult rat cardiomyocytes by endothelin-1. In: Fourth International Conference on Endothelin, London, UK, 23-26 Apr 1995, S297-S299.

This list was generated on Mon Mar 2 10:16:18 2015 GMT.