Dr Rachel Myles

  • Clinical Lecturer in Cardiology (Institute of Cardiovascular and Medical Sciences)
  • Associate (School of Medicine)

telephone: 01413302080
email: Rachel.Myles@glasgow.ac.uk

Biography

Dr Rachel Myles trained in medicine at the University of Oxford, gaining a First Class degree in Physiological Sciences, and thereafter at Guy’s and St. Thomas’ Hospital in London, graduating in 2001. She undertook general professional training in medicine at the Royal Infirmary of Edinburgh before moving to Glasgow in 2004 to pursue a career in academic and clinical cardiac electrophysiology. She completed a PhD in cardiac electrophysiology under the supervision of Professors Stuart Cobbe and Godfrey Smith in 2008 and was appointed as a Clinical Lecturer in Cardiology. She now divides her time between clinical training in cardiology and electrophysiology, and research into the mechanisms of ventricular arrhythmias in heart failure. She recently undertook a post-doctoral research fellowship at the University of California, Davis. 

Research interests

My current research approach combines both clinical and laboratory-based research, which utilizes optical imaging techniques to record voltage signals from intact myocardium in order to investigate the mechanisms of ventricular arrhythmias and sudden death in heart failure.

Research:

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Heterogeneity of sympathetic stimulation as a mechanism of ventricular arrhythmia following myocardial infarction
    Wellcome Trust
    2015 - 2020
     
  • Mechanisms of Early Afterdepolarisations in the Long QT Syndrome: A Study of Cellular Voltage and Calcium Dynamics in the Intact Heart
    Academy of Medical Sciences
    2013 - 2015
     
  • Electrophysiological remodelling and mechanisms of ventricular arrhythmia in dilated cardiomyopathy.
    British Heart Foundation
    2010 - 2011
     
  • Cellular basis for alternating T-wave morphology in isolated rabbit hearts
    British Heart Foundation
    2009 - 2012
     
  • Microvolt T-wave alternans in chronic heart failure: a study of prevalence and incremental prognostic value.
    Scottish Executive Health Department
    2007 - 2009
     
  • Microvolt T-wave alternans in chronic heart failure: a study of prevalence and incremental prognostic value.
    NHS Endowment Funds
    2007 - 2008
     
  • The role of repolarisation alternans in ventricular arrhythmia in a rabbit model of heart failure
    British Heart Foundation
    2006 - 2009
     

Publications

List by: Type | Date

Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008
Number of items: 16.

2015

Myles, R. C., Wang, L., Bers, D. M., and Ripplinger, C. M. (2015) Decreased inward rectifying K+current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart. Journal of Physiology, 593(6), pp. 1479-1493. (doi:10.1113/jphysiol.2014.279638) (PMID:25772297)

2014

Wang, L., Myles, R. C., De Jesus, N. M., Ohlendorf, A. K.P., Bers, D. M., and Ripplinger, C. M. (2014) Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Circulation research, 114(9), pp. 1410-1421. (doi:10.1161/​CIRCRESAHA.114.302505)

2013

Di Diego, J.M., Sicouri, S., Myles, R.C., Burton, F., Smith, G.L., and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi:10.1016/j.yjmcc.2012.10.017)

Jackson, C.E. et al. (2013) Feasibility/eligibility of T-wave alternans testing in patients with heart failure: should we rethink our current modus operandi?: reply. European Journal of Heart Failure, 14(6), pp. 676-677. (doi:10.1093/eurjhf/hfs050)

Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi:10.1161/CIRCEP.113.000334)

2012

Jackson, C.E., Myles, R.C., Cobbe, S.M., Petrie, M.C., and McMurray, J.J.V. (2012) Microvolt T-wave alternans testing has no role at present in guiding therapy for patients at high risk of ventricular arrhythmias. Journal of the American College of Cardiology, 59(9), p. 856. (doi:10.1016/j.jacc.2011.10.897)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi:10.1136/heartjnl-2012-301877b.17)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans testing should be used to guide arrhythmic therapy in heart failure patients: reply. European Journal of Heart Failure, 14(6), p. 678. (doi:10.1093/eurjhf/hfs077)

Jackson, C.E. et al. (2012) Profile of microvolt T-wave alternans testing in 1003 patients hospitalized with heart failure. European Journal of Heart Failure, 14(4), pp. 377-386. (doi:10.1093/eurjhf/hfs010)

Myles, R.C., Wang, L., Kang, C., Bers, D.M., and Ripplinger, C.M. (2012) Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circulation Research, 110(11), pp. 1454-1464. (doi:10.1161/CIRCRESAHA.111.262345)

Seegers, J. et al. (2012) Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype. Europace, 14(3), pp. 416-422. (doi:10.1093/europace/eur352)

2011

Myles, R., Burton, F.L., Cobbe, S., and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi:10.1016/j.yjmcc.2010.11.019 )

2010

Myles, R.C., Bernus, O., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi:10.1152/ajpheart.00518.2010)

2009

Jackson, C.E., Dalzell, J.R., Bezlyak, V., Tsorlalis, I.K., Myles, R.C., Spooner, R., Ford, I., Petrie, M.C., Cobbe, S., and McMurray, J.J. (2009) Red cell distribution width has incremental prognostic value to B-type natriuretic peptide in acute heart failure. European Journal of Heart Failure, 11(12), pp. 1152-1154. (doi:10.1093/eurjhf/hfp157)

2008

Lang, N.N., Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A., and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi:10.1016/j.bcp.2008.08.022 )

Myles, R.C., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi:10.1016/j.yjmcc.2008.03.024)

This list was generated on Fri Aug 28 18:23:00 2015 BST.
Jump to: Articles
Number of items: 16.

Articles

Myles, R. C., Wang, L., Bers, D. M., and Ripplinger, C. M. (2015) Decreased inward rectifying K+current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart. Journal of Physiology, 593(6), pp. 1479-1493. (doi:10.1113/jphysiol.2014.279638) (PMID:25772297)

Wang, L., Myles, R. C., De Jesus, N. M., Ohlendorf, A. K.P., Bers, D. M., and Ripplinger, C. M. (2014) Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Circulation research, 114(9), pp. 1410-1421. (doi:10.1161/​CIRCRESAHA.114.302505)

Di Diego, J.M., Sicouri, S., Myles, R.C., Burton, F., Smith, G.L., and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi:10.1016/j.yjmcc.2012.10.017)

Jackson, C.E. et al. (2013) Feasibility/eligibility of T-wave alternans testing in patients with heart failure: should we rethink our current modus operandi?: reply. European Journal of Heart Failure, 14(6), pp. 676-677. (doi:10.1093/eurjhf/hfs050)

Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi:10.1161/CIRCEP.113.000334)

Jackson, C.E., Myles, R.C., Cobbe, S.M., Petrie, M.C., and McMurray, J.J.V. (2012) Microvolt T-wave alternans testing has no role at present in guiding therapy for patients at high risk of ventricular arrhythmias. Journal of the American College of Cardiology, 59(9), p. 856. (doi:10.1016/j.jacc.2011.10.897)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi:10.1136/heartjnl-2012-301877b.17)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans testing should be used to guide arrhythmic therapy in heart failure patients: reply. European Journal of Heart Failure, 14(6), p. 678. (doi:10.1093/eurjhf/hfs077)

Jackson, C.E. et al. (2012) Profile of microvolt T-wave alternans testing in 1003 patients hospitalized with heart failure. European Journal of Heart Failure, 14(4), pp. 377-386. (doi:10.1093/eurjhf/hfs010)

Myles, R.C., Wang, L., Kang, C., Bers, D.M., and Ripplinger, C.M. (2012) Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circulation Research, 110(11), pp. 1454-1464. (doi:10.1161/CIRCRESAHA.111.262345)

Seegers, J. et al. (2012) Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype. Europace, 14(3), pp. 416-422. (doi:10.1093/europace/eur352)

Myles, R., Burton, F.L., Cobbe, S., and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi:10.1016/j.yjmcc.2010.11.019 )

Myles, R.C., Bernus, O., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi:10.1152/ajpheart.00518.2010)

Jackson, C.E., Dalzell, J.R., Bezlyak, V., Tsorlalis, I.K., Myles, R.C., Spooner, R., Ford, I., Petrie, M.C., Cobbe, S., and McMurray, J.J. (2009) Red cell distribution width has incremental prognostic value to B-type natriuretic peptide in acute heart failure. European Journal of Heart Failure, 11(12), pp. 1152-1154. (doi:10.1093/eurjhf/hfp157)

Lang, N.N., Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A., and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi:10.1016/j.bcp.2008.08.022 )

Myles, R.C., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi:10.1016/j.yjmcc.2008.03.024)

This list was generated on Fri Aug 28 18:23:00 2015 BST.