Prof Muriel Caslake

Prof Muriel Caslake
  • Professor (Institute of Cardiovascular and Medical Sciences)

telephone: 01412112161
email: Muriel.Caslake@glasgow.ac.uk


Professor Muriel Caslake’s research interests are based on the structure, function and metabolism of the lipoproteins in normality and diseases such as hyperlipidaemia, renal disease, type 2 diabetes and in pregnancy. Her particular areas of current activities and expertise include the detailed analysis of lipoprotein subfractions; the measurement of lipoprotein metabolism using stable isotope tracers for apolipoproteins and lipids; the influence of diet, drugs, obesity and exercise on lipoprotein metabolism; and the improvement in the detection of the patient at risk using novel risk factors. This activity has resulted in over 100 publications. She receives funding from a number of charities (such as BHF), government agencies (such as FSA) and industrial partners (such as GSK).

Professor Caslake studied for her undergraduate degree in Biochemistry at Queens University Belfast. Subsequently she worked as a Biomedical Scientist at Belfast City Hospital where she obtained an AIMLS. In 1974 she moved across the Irish Sea and has been based since then at Glasgow Royal Infirmary. She was awarded FIMLS by thesis and received a PhD from the University of Glasgow for a thesis entitled "Studies on the structural and metabolic heterogeneity in low density lipoprotein". She currently leads the Vascular Biochemistry Group, Faculty of Medicine, University of Glasgow, which is located at Glasgow Royal Infirmary.

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Number of items: 91.

2013

Forbes, S. et al. (2013) A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid. Diabetologia, 56 (9). pp. 2021-2033. ISSN 0012-186X (doi:10.1007/s00125-013-2956-3)

Meyer, B.J., Stewart, F.M., Brown, E.A., Cooney, J., Nilsson, S., Olivecrona, G., Ramsay, J.E., Griffin, B.A., Caslake, M.J., and Freeman, D.J. (2013) Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester. Journal of Clinical Endocrinology and Metabolism, 98 (2). pp. 643-652. ISSN 0021-972X (doi:10.1210/jc.2012-3481)

2012

Kaptoge, S. et al. (2012) C-reactive protein, fibrinogen, and cardiovascular disease prediction. New England Journal of Medicine, 367 (14). pp. 1310-1320. ISSN 0028-4793 (doi:10.1056/NEJMoa1107477)

Di Angelantonio, E. et al. (2012) Lipid-related markers and cardiovascular disease prediction. JAMA: Journal of the American Medical Association, 307 (23). pp. 2499-2506. ISSN 0098-7484 (doi:10.1001/jama.2012.6571)

Al-Shayji, I.A.R., Caslake, M.J., and Gill, J.M.R. (2012) Effects of moderate exercise on VLDL1 and Intralipid kinetics in overweight/obese middle-aged men. American Journal of Physiology: Endocrinology and Metabolism, 302 (3). E349-E355. ISSN 0193-1849 (doi:10.1152/ajpendo.00498.2011)

Kofler, B.M. et al. (2012) Apolipoprotein E genotype and the cardiovascular disease risk phenotype: Impact of sex and adiposity (the FINGEN study). Atherosclerosis, 221 (2). pp. 467-470. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2012.01.042)

Lockington, D., Cooney, J., Lewis, A., Agarwal, P., Caslake, M., and Ramaesh, K. (2012) Substance P concentration in human amniotic membrane. Archives of Ophthalmology, 130 (4). pp. 522-523. ISSN 0003-9950 (doi:10.1001/archophthalmol.2011.1452)

Lockington, D., Macdonald, E.C.A., Stewart, P., Young, D., Caslake, M., and Ramaesh, K. (2012) Free radicals and the pH of topical glaucoma medications: a lifetime of ocular chemical injury? Eye, 26 (5). pp. 734-741. ISSN 0950-222X (doi:10.1038/eye.2012.25)

2011

Trompet, S. et al. (2011) Replication of LDL SWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses. BMC Medical Genetics , 12 . p. 131. ISSN 1471-2350 (doi:10.1186/1471-2350-12-131)

Dominiczak, M.H., and Caslake, M.J. (2011) Apolipoproteins: metabolic role and clinical biochemistry applications. Annals of Clinical Biochemistry, 48 (6). pp. 498-515. ISSN 0004-5632 (doi:10.1258/acb.2011.011111)

Trompet, S. et al. (2011) Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses. BMC Medical Genetics, 12 (131). ISSN 1471-2350 (doi:10.1186/1471-2350-12-131)

2010

Kluger, E.K., Caslake, M., Baral, R.M., Malik, R., and Govendir, M. (2010) Preliminary post-prandial studies of Burmese cats with elevated triglyceride concentrations and/or presumed lipid aqueous. Journal of Feline Medicine and Surgery, 12 (8). pp. 621-630. ISSN 1098-612X (doi:10.1016/j.jfms.2010.04.002)

Caslake, M.J. et al. (2010) Lipoprotein-associated phospholipase A2 inflammatory biomarkers, and risk of cardiovascular disease in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Atherosclerosis, 210 (1). pp. 28-34. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2009.10.041 )

Caslake, M.J. et al. (2010) Lipoprotein-associated phospholipase A(2), inflammatory biomarkers, and risk of cardiovascular disease in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Atherosclerosis, 210 (1). pp. 28-34. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2009.10.041)

Lockington, D., Macdonald, E., Gregory, M., Stewart, P., Caslake, M., and Ramaesh, K. (2010) Presence of free radicals in commonly used ophthalmic preparations. British Journal of Ophthalmology, 94 (4). pp. 525-526. ISSN 0007-1161 (doi:10.1136/bjo.2009.162495)

Patel, J.V. et al. (2010) Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations. Atherosclerosis, 209 (2). pp. 579-584. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2009.10.010)

Olano-Martin, E., Anil, E., Caslake, M.J., Packard, C.J., Bedford, D., Stewart, G., Peiris, D., Williams, C.M., and Minihane, A.M. (2010) Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil. Atherosclerosis, 209 (1). pp. 104-110. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2009.08.024)

Yang, M., Chu, E.M., Caslake, M.J., Edelstein, C., Scanu, A.M., and Hill, J.S. (2010) Lipoprotein-associated phospholipase A2 decreases oxidized lipoprotein cellular association by human macrophages and hepatocytes. Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1801 (2). pp. 176-182. ISSN 1388-1981 (doi:10.1016/j.bbalip.2009.10.011)

Burton, F.L., Malkova, D., Caslake, M.J., and Gill, J.M.R. (2010) Substrate metabolism, appetite and feeding behaviour under low and high energy turnover conditions in overweight women. British Journal of Nutrition, 104 (8). pp. 1249-1259. ISSN 0007-1145 (doi:10.1017/S0007114510002023)

Felmlee, D.J., Sheridan, D.A., Bridge, S.H., Nielsen, S.U., Milne, R.W., Packard, C.J., Caslake, M.J., McLauchlan, J., Toms, G.L., and Neely, R.D.G. (2010) Intravascular transfer contributes to postprandial increase in numbers of very-low-density hepatitis C virus particles. Gastroenterology, 139 (5). pp. 1774-1783. ISSN 0016-5085 (doi:10.1053/j.gastro.2010.07.047)

Lockington, D., Macdonald, E.C.A., Young, D., Stewart, P., Caslake, M., and Ramaesh, K. (2010) Presence of free radicals in intracameral agents commonly used during cataract surgery. British Journal of Ophthalmology, 94 (12). pp. 1674-1677. ISSN 0007-1161 (doi:10.1136/bjo.2009.171009)

Thompson, A. et al. (2010) Lipoprotein-associated phospholipase A2 and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies. Lancet, 375 (9725). pp. 1536-1544. ISSN 0140-6736 (doi:10.1016/S0140-6736(10)60319-4)

2009

Trompet, S. et al. (2009) Apolipoprotein E genotype, plasma cholesterol, and cancer: a mendelian randomization study. American Journal of Epidemiology, 170 (11). pp. 1415-1421. ISSN 0002-9262 (doi:10.1093/aje/kwp294)

Bell, S., Cooney, J., Packard, C.J., Caslake, M., and Deighan, C.J. (2009) Omega-3 fatty acids improve postprandial lipaemia in patients with nephrotic range proteinuria. Atherosclerosis, 205 (1). pp. 296-301. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2008.12.002)

2008

Caslake, M.J. et al. (2008) Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN study. American Journal of Clinical Nutrition, 88 (3). pp. 618-629. ISSN 0002-9165

Duvillard, L., Caslake, M.J., Petit, J.M., Verges, B., Gambert, P., and Packard, C.J. (2008) Distinct patterns of heparin affinity chromatography VLDL1 and VLDL2 subfractions in the different dyslipidaemias. Atherosclerosis, 199 (1). pp. 27-33. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2007.11.026 )

de Roos, B., Geelen, A., Ross, K., Rucklidge, G., Reid, M., Duncan, G., Caslake, M., Horgan, G., and Brouwer, I.A. (2008) Identification of potential serum biomarkers of inflammation and lipid modulation that are altered by fish oil supplementation in healthy volunteers. Proteomics, 8 (10). pp. 1965-1974. ISSN 1615-9853 (doi:10.1002/pmic.200700457)

Takagi, T. et al. (2008) Effect of pravastatin on the development of diabetes and adiponectin production. Atherosclerosis, 196 (1). pp. 114-121. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2007.02.013)

Burton, F.L., Malkova, D., Caslake, M.J., and Gill, J.M.R. (2008) Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese men. International Journal of Obesity, 32 (3). pp. 481-489. ISSN 0307-0565 (doi:10.1038/sj.ijo.0803754)

Cramb, R., French, J., Mackness, M., Neely, R.D.G., Caslake, M., and MacKenzie, F. (2008) Lipid external quality assessment: commutability between external quality assessment and clinical specimens. Annals of Clinical Biochemistry, 45 (3). pp. 260-265. ISSN 0004-5632 (doi:10.1258/acb.2007.007120)

Durrington, PN, Charlton-Menys, V, Packard, CJ, Caslake, M, Wang, J, Bhatnagar, D, Scott, J, Scott, J, and Hegele, RA (2008) Familial hypobetalipoproteinemia due to a novel early stop mutation. Journal of Clinical Lipidology, 2 (5). pp. 384-390.

2007

Meyer, B.J., Duvillard, L., Owen, A., Packard, C.J., and Caslake, M.J. (2007) Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate. Atherosclerosis, 195 (2). e28-e34. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2007.01.001)

Adiels, M. et al. (2007) Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance. Diabetologia, 50 (11). pp. 2356-2365. ISSN 0012-186X (doi:10.1007/s00125-007-0790-1)

Packard, C.J. et al. (2007) Association between apolipoprotein E4 and cognitive decline in elderly adults. Journal of the American Geriatrics Society, 55 (11). pp. 1777-1785. ISSN 0002-8614 (doi:10.1111/j.1532-5415.2007.01415.x)

Al-Shayji, I.A., Gill, J.M.R., Cooney, J., Siddiqui, S., and Caslake, M.J. (2007) Development of a novel method to determine very low density lipoprotein kinetics. Journal of Lipid Research, 48 . pp. 2086-2095. ISSN 0022-2275 (doi:10.1194/jlr.D600044-JLR200)

Gill, J.M., Al-Mamari, A., Ferrell, W.R., Cleland, S.J., Perry, C.G., Sattar, N., Packard, C.J., Caslake, M.J., and Petrie, J.R. (2007) Effect of prior moderate exercise on postprandial metabolism in men with type 2 diabetes: Heterogeneity of responses. Atherosclerosis, 194 (1). pp. 134-143. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2006.10.007)

Lara, J.J., Economou, M., Wallace, A.M., Rumley, A., Lowe, G., Slater, C., Caslake, M., Sattar, N., and Lean, M.E.J. (2007) Benefits of salmon eating on traditional and novel vascular risk factors in young, non-obese healthy subjects. Atherosclerosis, 193 (1). pp. 213-221. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2006.06.018)

Geberhiwot, T., Alger, S., McKiernan, P., Packard, C., Caslake, M., Elias, E., and Cramb, R. (2007) Serum lipid and lipoprotein profile of patients with glycogen storage disease types I, III and IX. Journal of Inherited Metabolic Disease, 30 (3). p. 406. ISSN 0141-8955 (doi:10.1007/s10545-007-0485-2)

Sola, R. et al. (2007) Effects of soluble fiber (Plantago ovata husk) on plasma lipids, lipoproteins, and apolipoproteins in men with ischemic heart disease. American Journal of Clinical Nutrition, 85 (4). pp. 1157-1163. ISSN 0002-9165

Stewart, F.M., Freeman, D.J., Ramsay, J.E., Greer, I.A., Caslake, M., and Ferrell, W.R. (2007) Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothers. Journal of Clinical Endocrinology and Metabolism, 92 (3). pp. 969-975. ISSN 0021-972X (doi:10.1210/jc.2006-2083)

Adiels, M et al. (2007) Acute suppression of VLDL(1) secretion rate by insulin is associated with hepatic fat content and insulin resistance. Diabetologia, 50 (11). pp. 2356-2365.

2006

Adiels, M. et al. (2006) Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia, 49 (4). pp. 755-765. ISSN 0012-186X (doi:10.1007/s00125-005-0125-z)

O'Reilly, D., Upton, M.N., Caslake, M.J., Robertson, M., Norrie, J., McConnachie, A., Watt, G.C.M., and Packard, C.J. (2006) Plasma C reactive protein concentration indicates a direct relation between systemic inflammation and social deprivation. Heart, 92 (4). pp. 533-535. ISSN 1355-6037 (doi:10.1136/hrt.2005.063081)

Hayek, T., Stephens, J.W., Hubbart, C.S., Acharya, J., Caslake, M.J., Hawe, E., Miller, G.J., Hurel, S.J., and Humphries, S.E. (2006) A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus. Atherosclerosis, 184 (2). pp. 404-412. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2005.05.017)

Gill, JM, Al-Mamari, A, Ferrell, WR, Cleland, SJ, Sattar, N, Packard, CJ, Petrie, JR, and Caslake, MJ (2006) Effects of a moderate exercise session on postprandial lipoproteins, apolipoproteins and lipoprotein remnants in middle-aged men. Atherosclerosis, 185 (1). pp. 87-96. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2005.06.009)

Lundahl, B., Skoglund-Andersson, C., Caslake, M., Bedford, D., Stewart, P., Hamsten, A., Packard, C.J., and Karpe, F. (2006) Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles. American Journal of Physiology: Endocrinology and Metabolism, 290 (4). E739-E745. ISSN 0193-1849 (doi:10.1152/ajpendo.00376.2005)

2005

Belo, L., Santos-Silva, A., Caslake, M., Pereira-Leite, L., Quintanilha, A., and Rebelo, I. (2005) Oxidized-LDL levels in normal and pre-eclamptic pregnancies: Contribution of LDL particle size. Atherosclerosis, 183 (1). pp. 185-186. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2005.06.028)

Adiels, M, Packard, C, Caslake, M, Stewart, P, Soro, A, Westerbacka, J, Wennberg, B, Olofsson, SO, Taskinen, MR, and Boren, J (2005) A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions. Journal of Lipid Research, 46 (1). pp. 58-67.

Adiels, M., Boren, J., Caslake, M., Stewart, P., Soro, A., Westerbacka, J., Wennberg, B., Olofsson, S.O., Packard, C., and Taskinen, M.R. (2005) Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia. Arteriosclerosis, Thrombosis and Vascular Biology, 25 (8). pp. 1697-1703. ISSN 1079-5642

Belo, L., Santos-Silva, A., Rocha, S., Caslake, M., Cooney, J., Pereira-Leite, L., Quintanilha, A., and Rebelo, I. (2005) Fluctuations in C-reactive protein concentration and neutrophil activation during normal human pregnancy. European Journal of Obstetrics, Gynecology and Reproductive Biology, 123 . pp. 46-51. ISSN 0301-2115 (doi:10.1016/j.ejogrb.2005.02.022)

Caslake, M.J., and Packard, C.J. (2005) Lipoprotein-associated phospholipase A2 as a biomarker for coronary disease and stroke. Nature Clinical Practice Cardiovascular Medicine, 2 (10). pp. 529-535. ISSN 1743-4297 (doi:10.1038/ncpcardio0321)

Caslake, MJ, Gill, JMR, Higgins, S, Janilionyte, R, and Malkova, D (2005) Physical activity, dietary intake and metabolic risk factors in non-diabetic daughters of patients with type II diabetes. Preventive Medicine, 40 . pp. 145-151. (doi:10.1016/j.ypmed.2004.05.004)

Charakida, M et al. (2005) Early structural and functional changes of the vasculature in HIV-infected children - Impact of disease and antiretroviral therapy. Circulation, 112 . pp. 103-109. (doi:10.1161/CIRCULATIONAHA.104.5.17144)

Charakida, M et al. (2005) Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy. Circulation, 112 (1). pp. 103-109.

Stephens, JW, Sozen, MM, Whittall, RA, Caslake, MJ, Bedford, D, Acharya, J, Hurel, SJ, and Humphries, SE (2005) Three novel mutations in the apolipoprotein E gene in a sample of individuals with type 2 diabetes mellitus. Clinical Chemistry, 51 . pp. 119-124. (doi:10.1373/j.clinchem.2004.040121)

de Roos, B, Caslake, M, Milliner, K, Benson, GM, Suckling, KE, and Packard, CJ (2005) Characterisation of the lipoprotein structure in the St. Thomas' Mixed Hyperlipidaemic (SMHL) rabbit. Atherosclerosis, 181 (1). pp. 63-68. ISSN 0021-9150

2004

Belo, L, Caslake, M, Santos-Silva, A, Castro, EM, Pereira-Leite, L, Quintanilha, A, and Rebelo, I (2004) LDL size, total antioxidant status and oxidised LDL in normal human pregnancy: a longitudinal study. Atherosclerosis, 177 . pp. 391-399. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2004.07.023)

Belo, L., Gaffney, D., Caslake, M., Santos-Silva, A., Pereira-Leite, L., Quintanilha, A., and Rebelo, I. (2004) Apolipoprotein E and cholesteryl ester transfer protein polymorphisms in normal and preeclamptic pregnancies. European Journal of Obstetrics, Gynecology and Reproductive Biology, 112 . pp. 9-15. ISSN 0301-2115 (doi:10.1016/S0301-2115(03)00240-9)

Caslake, M, and Packard, CJ (2004) Phenotypes, genotypes and response to statin therapy. Curr Opin Lipidol, 15 (4). pp. 387-392.

Chapman, MJ, and Caslake, M (2004) Non-high-density lipoprotein cholesterol as a risk factor: addressing risk associated with apolipoprotein B-containing lipoproteins. European Heart Journal Supplements, 6 (A). A43-A48.

Gill, J.M.R., Al-Mamari, A., Ferrell, W.R., Cleland, S.J., Packard, C.J., Sattar, N., Petrie, J.R., and Caslake, M.J. (2004) Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men. Journal of the American College of Cardiology, 44 (12). pp. 2375-2382. ISSN 0735-1097 (doi:10.1016/j.jacc.2004.09.035)

Gill, JM, Brown, JC, Bedford, D, Wright, DM, Cooney, J, Hughes, DA, Packard, CJ, and Caslake, M (2004) Hepatic production of VLDL(1) but not VLDL(2) is related to insulin resistance in normoglycaemic middle-aged subjects. Atherosclerosis, 176 (1). pp. 49-56. ISSN 0021-9150

Gill, JMR, Brown, JC, Bedford, D, Wright, DM, Cooney, J, Hughes, DA, Packard, CJ, and Caslake, MJ (2004) Hepatic production of VLDL1 but not VLDL2 is related to insulin resistance in normoglycaemic middle-aged subjects. Atherosclerosis, 176 . pp. 49-56. (doi:10.1016/j.atherosclerosis.2004.04.022)

Menys, VC, Liu, Y, Mackness, MI, Kwok, S, Caslake, M, Stewart, G, and Durrington, PN (2004) Isolation of plasma small-dense low-density lipoprotein using a simple air-driven ultracentrifuge and quantification using immunoassay of apolipoprotein B. Clinical Chemistry and Laboratory Medicine, 42 (1). pp. 30-36.

Rodie, VA, Caslake, MJ, Stewart, F, Sattar, N, Ramsay, JE, Greer, IA, and Freeman, DJ (2004) Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. Atherosclerosis, 176 . pp. 181-187. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2004.04.026)

2003

Belo, L, Santos-Silva, A, Caslake, M, Cooney, J, Pereira-Leite, L, Quintanilha, A, and Rebelo, I (2003) Neutrophil activation and C-reactive protein concentration in preeclampsia. Hypertension in Pregnancy, 22 . pp. 129-141. (doi:10.1081/PRG-120021059)

Caslake, M, and Packard, CJ (2003) Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease. Curr Opin Lipidol, 14 (4). pp. 347-352.

Caslake, M et al. (2003) Phenotype-dependent and -independent actions of rosuvastatin on atherogenic lipoprotein subfractions in hyperlipidaemia. Atherosclerosis, 171 (2). pp. 245-253. ISSN 0021-9150

Caslake, MJ, Ferrell, WR, Gill, JMR, Malkova, D, McAllister, C, Packard, CJ, and Tsofliou, F (2003) Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: Dissociation between changes in triglyceride metabolism and endothelial function. Journal of Clinical Endocrinology and Metabolism, 88 . pp. 4328-4335. (doi:10.1210/jc.2003-030226)

Chapman, MJ, Caslake, M, Packard, C, and McTaggart, F (2003) New dimension of statin action on ApoB atherogenicity. Clinical Cardiology, 26 (1 Supp). I7-10. ISSN 0160-9289

Freeman, DJ, Samani, NJ, Wilson, V, McMahon, AD, Braund, PS, Cheng, S, Caslake, MJ, Packard, CJ, and Gaffney, D (2003) A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study. European Heart Journal, 24 . pp. 1833-1842. (doi:10.1016/j.ehj.2003.07.001)

Gill, JM, Caslake, M, McAllister, C, Tsofliou, F, Ferrell, WR, Packard, CJ, and Malkova, D (2003) Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: dissociation between changes in triglyceride metabolism and endothelial function. j.gill@bio.gla.ac.uk. Journal of Clinical Endocrinology and Metabolism, 88 (9). pp. 4328-4335. ISSN 0021-972X

Kay, AD, Day, SP, Kerr, M, Nicoll, JA, Packard, CJ, and Caslake, MJ (2003) Remodeling of cerebrospinal fluid lipoprotein particles after human traumatic brain injury. Journal of Neurotrauma, 20 . pp. 717-723.

Kay, AD, Day, SP, Nicoll, JA, Packard, CJ, and Caslake, MJ (2003) Remodelling of cerebrospinal fluid lipoproteins after subarachnoid hemorrhage. Atherosclerosis, 170 . pp. 141-146. ISSN 0021-9150 (doi:10.1016/S0021-9150(03)00249-1)

Menys, VC, Liu, Y, Mackness, MI, Caslake, M, Kwok, S, and Durrington, PN (2003) Measurement of plasma small-dense LDL concentration by a simplified ultracentrifugation procedure and immunoassay of apolipoprotein B. Clinica Chimica Acta, 334 (01-Feb). pp. 95-106. ISSN 0009-8981

2002

Muriithi, E.W., Belcher, P.R., Day, S., Chaudhry, M.A., Caslake, M.J., and Wheatley, D.J. (2002) Lipolysis generates platelet dysfunction after in vivo heparin administration. Clinical Science, 103 (4). pp. 433-440. ISSN 0143-5221

Belo, L, Caslake, M, Gaffney, D, Santos-Silva, A, Pereira-Leite, L, Quintanilha, A, and Rebelo, I (2002) Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies. Atherosclerosis, 162 (2). pp. 425-432. ISSN 0021-9150

Belo, L, Caslake, M, Santos-Silva, A, Pereira-Leite, L, Quintanilha, A, and Rebelo, I (2002) Lipoprotein(a): a longitudinal versus a cross-sectional study in normal pregnancy and its levels in preeclampsia. Atherosclerosis, 165 (2). pp. 393-395. ISSN 0021-9150

Cho, HK, Shin, G, Ryu, SK, Jang, Y, Day, SP, Stewart, G, Packard, CJ, Shepherd, J, and Caslake, MJ (2002) Regulation of small dense LDL concentration in Korean and Scottish men and women. Atherosclerosis, 164 . pp. 187-193. ISSN 0021-9150

Forster, LF, Stewart, G, Bedford, D, Stewart, JP, Rogers, E, Shepherd, J, Packard, CJ, and Caslake, M (2002) Influence of atorvastatin and simvastatin on apolipoprotein B metabolism in moderate combined hyperlipidemic subjects with low VLDL and LDL fractional clearance rates. Atherosclerosis, 164 (1). pp. 129-145. ISSN 0021-9150

Freeman, D.J., Norrie, J., Caslake, M.J., Gaw, A., Ford, I., Lowe, G.D.O., O'Reilly, D. St. J,, Packard, C.J., and Sattar, N. (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes, 51 (5). pp. 1596-1600. ISSN 0012-1797 (doi:10.2337/diabetes.51.5.1596)

Freeman, D.J., Norrie, J., Caslake, M.J., Gaw, A., Ford, I., Lowe, G.D.O., O'Reilly, D.S., Packard, C.J., and Sattar, N. (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes, 51 (5). pp. 1596-1600. ISSN 0012-1797

Gaffney, D, Forster, L, Caslake, M, Bedford, D, Stewart, JP, Stewart, G, Wieringa, G, Dominiczak, M, Miller, JP, and Packard, CJ (2002) Comparison of apolipoprotein B metabolism in familial defective apolipoprotein B and heterogeneous familial hypercholesterolemia. Atherosclerosis, 162 (1). pp. 33-43. ISSN 0021-9150

Muriithi, EW, Belcher, PR, Day, SP, Chaudhry, MA, Caslake, MJ, and Wheatley, DJ (2002) Lipolysis generates platelet dysfunction after in vivo heparin administration. Clinical Science, 103 . pp. 433-440.

2001

Deighan, CJ, Caslake, M, McConnell, M, Boulton-Jones, JM, and Packard, CJ (2001) Comparative effects of cerivastatin and fenofibrate on the atherogenic lipoprotein phenotype in proteinuric renal disease. Journal of the American Society of Nephrology, 12 (2). pp. 341-348.

Deighan, CJ, Caslake, M, McConnell, M, Boulton-Jones, JM, and Packard, CJ (2001) The atherogenic lipoprotein phenotype: small dense LDL and lipoprotein remnants in nephrotic range proteinuria. Atherosclerosis, 157 (1). pp. 211-220. ISSN 0021-9150

Shahmanesh, M, Jaleel, H, DeSilva, Y, Ross, JD, Caslake, M, and Cramb, R (2001) Protease inhibitor related type III hyperlipoproteinaemia is common and not associated with apolipoprotein-E E2/E2 phenotype. Sexually Transmitted Infections, 77 . pp. 283-286.

de Roos, B, Caslake, M, Ardern, HA, Martin, BG, Suckling, KE, and Packard, CJ (2001) Insulin resistance in the St. Thomas' mixed hyperlipidaemic (SMHL) rabbit, a model for familial combined hyperlipidaemia. Atherosclerosis, 156 (2). pp. 249-254. ISSN 0021-9150

de Roos, B, Caslake, M, Stalenhoef, AF, Bedford, D, Demacker, PN, Katan, MB, and Packard, CJ (2001) The coffee diterpene cafestol increases plasma triacylglycerol by increasing the production rate of large VLDL apolipoprotein B in healthy normolipidemic subjects. American Journal of Clinical Nutrition, 73 (1). pp. 45-52. ISSN 0002-9165

2000

Packard, C.J. et al. (2000) Lipoprotein-associated phospholipse A2 as an independent predictor of coronary heart disease (WOSCOPS). New England Journal of Medicine, 343 (16). pp. 1148-1155. ISSN 0028-4793 (doi:10.1056/NEJM200010193431603)

Packard, C.J. et al. (2000) Lipoprotein-associated phospholipase A(2) as an independent predictor of coronary heart disease. New England Journal of Medicine, 343 (16). pp. 1148-1155. ISSN 0028-4793

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Article

Forbes, S. et al. (2013) A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid. Diabetologia, 56 (9). pp. 2021-2033. ISSN 0012-186X (doi:10.1007/s00125-013-2956-3)

Meyer, B.J., Stewart, F.M., Brown, E.A., Cooney, J., Nilsson, S., Olivecrona, G., Ramsay, J.E., Griffin, B.A., Caslake, M.J., and Freeman, D.J. (2013) Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester. Journal of Clinical Endocrinology and Metabolism, 98 (2). pp. 643-652. ISSN 0021-972X (doi:10.1210/jc.2012-3481)

Kaptoge, S. et al. (2012) C-reactive protein, fibrinogen, and cardiovascular disease prediction. New England Journal of Medicine, 367 (14). pp. 1310-1320. ISSN 0028-4793 (doi:10.1056/NEJMoa1107477)

Di Angelantonio, E. et al. (2012) Lipid-related markers and cardiovascular disease prediction. JAMA: Journal of the American Medical Association, 307 (23). pp. 2499-2506. ISSN 0098-7484 (doi:10.1001/jama.2012.6571)

Al-Shayji, I.A.R., Caslake, M.J., and Gill, J.M.R. (2012) Effects of moderate exercise on VLDL1 and Intralipid kinetics in overweight/obese middle-aged men. American Journal of Physiology: Endocrinology and Metabolism, 302 (3). E349-E355. ISSN 0193-1849 (doi:10.1152/ajpendo.00498.2011)

Kofler, B.M. et al. (2012) Apolipoprotein E genotype and the cardiovascular disease risk phenotype: Impact of sex and adiposity (the FINGEN study). Atherosclerosis, 221 (2). pp. 467-470. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2012.01.042)

Lockington, D., Cooney, J., Lewis, A., Agarwal, P., Caslake, M., and Ramaesh, K. (2012) Substance P concentration in human amniotic membrane. Archives of Ophthalmology, 130 (4). pp. 522-523. ISSN 0003-9950 (doi:10.1001/archophthalmol.2011.1452)

Lockington, D., Macdonald, E.C.A., Stewart, P., Young, D., Caslake, M., and Ramaesh, K. (2012) Free radicals and the pH of topical glaucoma medications: a lifetime of ocular chemical injury? Eye, 26 (5). pp. 734-741. ISSN 0950-222X (doi:10.1038/eye.2012.25)

Trompet, S. et al. (2011) Replication of LDL SWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses. BMC Medical Genetics , 12 . p. 131. ISSN 1471-2350 (doi:10.1186/1471-2350-12-131)

Dominiczak, M.H., and Caslake, M.J. (2011) Apolipoproteins: metabolic role and clinical biochemistry applications. Annals of Clinical Biochemistry, 48 (6). pp. 498-515. ISSN 0004-5632 (doi:10.1258/acb.2011.011111)

Trompet, S. et al. (2011) Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses. BMC Medical Genetics, 12 (131). ISSN 1471-2350 (doi:10.1186/1471-2350-12-131)

Kluger, E.K., Caslake, M., Baral, R.M., Malik, R., and Govendir, M. (2010) Preliminary post-prandial studies of Burmese cats with elevated triglyceride concentrations and/or presumed lipid aqueous. Journal of Feline Medicine and Surgery, 12 (8). pp. 621-630. ISSN 1098-612X (doi:10.1016/j.jfms.2010.04.002)

Caslake, M.J. et al. (2010) Lipoprotein-associated phospholipase A2 inflammatory biomarkers, and risk of cardiovascular disease in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Atherosclerosis, 210 (1). pp. 28-34. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2009.10.041 )

Caslake, M.J. et al. (2010) Lipoprotein-associated phospholipase A(2), inflammatory biomarkers, and risk of cardiovascular disease in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Atherosclerosis, 210 (1). pp. 28-34. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2009.10.041)

Lockington, D., Macdonald, E., Gregory, M., Stewart, P., Caslake, M., and Ramaesh, K. (2010) Presence of free radicals in commonly used ophthalmic preparations. British Journal of Ophthalmology, 94 (4). pp. 525-526. ISSN 0007-1161 (doi:10.1136/bjo.2009.162495)

Patel, J.V. et al. (2010) Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations. Atherosclerosis, 209 (2). pp. 579-584. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2009.10.010)

Olano-Martin, E., Anil, E., Caslake, M.J., Packard, C.J., Bedford, D., Stewart, G., Peiris, D., Williams, C.M., and Minihane, A.M. (2010) Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil. Atherosclerosis, 209 (1). pp. 104-110. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2009.08.024)

Yang, M., Chu, E.M., Caslake, M.J., Edelstein, C., Scanu, A.M., and Hill, J.S. (2010) Lipoprotein-associated phospholipase A2 decreases oxidized lipoprotein cellular association by human macrophages and hepatocytes. Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1801 (2). pp. 176-182. ISSN 1388-1981 (doi:10.1016/j.bbalip.2009.10.011)

Burton, F.L., Malkova, D., Caslake, M.J., and Gill, J.M.R. (2010) Substrate metabolism, appetite and feeding behaviour under low and high energy turnover conditions in overweight women. British Journal of Nutrition, 104 (8). pp. 1249-1259. ISSN 0007-1145 (doi:10.1017/S0007114510002023)

Felmlee, D.J., Sheridan, D.A., Bridge, S.H., Nielsen, S.U., Milne, R.W., Packard, C.J., Caslake, M.J., McLauchlan, J., Toms, G.L., and Neely, R.D.G. (2010) Intravascular transfer contributes to postprandial increase in numbers of very-low-density hepatitis C virus particles. Gastroenterology, 139 (5). pp. 1774-1783. ISSN 0016-5085 (doi:10.1053/j.gastro.2010.07.047)

Lockington, D., Macdonald, E.C.A., Young, D., Stewart, P., Caslake, M., and Ramaesh, K. (2010) Presence of free radicals in intracameral agents commonly used during cataract surgery. British Journal of Ophthalmology, 94 (12). pp. 1674-1677. ISSN 0007-1161 (doi:10.1136/bjo.2009.171009)

Thompson, A. et al. (2010) Lipoprotein-associated phospholipase A2 and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies. Lancet, 375 (9725). pp. 1536-1544. ISSN 0140-6736 (doi:10.1016/S0140-6736(10)60319-4)

Trompet, S. et al. (2009) Apolipoprotein E genotype, plasma cholesterol, and cancer: a mendelian randomization study. American Journal of Epidemiology, 170 (11). pp. 1415-1421. ISSN 0002-9262 (doi:10.1093/aje/kwp294)

Bell, S., Cooney, J., Packard, C.J., Caslake, M., and Deighan, C.J. (2009) Omega-3 fatty acids improve postprandial lipaemia in patients with nephrotic range proteinuria. Atherosclerosis, 205 (1). pp. 296-301. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2008.12.002)

Caslake, M.J. et al. (2008) Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN study. American Journal of Clinical Nutrition, 88 (3). pp. 618-629. ISSN 0002-9165

Duvillard, L., Caslake, M.J., Petit, J.M., Verges, B., Gambert, P., and Packard, C.J. (2008) Distinct patterns of heparin affinity chromatography VLDL1 and VLDL2 subfractions in the different dyslipidaemias. Atherosclerosis, 199 (1). pp. 27-33. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2007.11.026 )

de Roos, B., Geelen, A., Ross, K., Rucklidge, G., Reid, M., Duncan, G., Caslake, M., Horgan, G., and Brouwer, I.A. (2008) Identification of potential serum biomarkers of inflammation and lipid modulation that are altered by fish oil supplementation in healthy volunteers. Proteomics, 8 (10). pp. 1965-1974. ISSN 1615-9853 (doi:10.1002/pmic.200700457)

Takagi, T. et al. (2008) Effect of pravastatin on the development of diabetes and adiponectin production. Atherosclerosis, 196 (1). pp. 114-121. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2007.02.013)

Burton, F.L., Malkova, D., Caslake, M.J., and Gill, J.M.R. (2008) Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese men. International Journal of Obesity, 32 (3). pp. 481-489. ISSN 0307-0565 (doi:10.1038/sj.ijo.0803754)

Cramb, R., French, J., Mackness, M., Neely, R.D.G., Caslake, M., and MacKenzie, F. (2008) Lipid external quality assessment: commutability between external quality assessment and clinical specimens. Annals of Clinical Biochemistry, 45 (3). pp. 260-265. ISSN 0004-5632 (doi:10.1258/acb.2007.007120)

Durrington, PN, Charlton-Menys, V, Packard, CJ, Caslake, M, Wang, J, Bhatnagar, D, Scott, J, Scott, J, and Hegele, RA (2008) Familial hypobetalipoproteinemia due to a novel early stop mutation. Journal of Clinical Lipidology, 2 (5). pp. 384-390.

Meyer, B.J., Duvillard, L., Owen, A., Packard, C.J., and Caslake, M.J. (2007) Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate. Atherosclerosis, 195 (2). e28-e34. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2007.01.001)

Adiels, M. et al. (2007) Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance. Diabetologia, 50 (11). pp. 2356-2365. ISSN 0012-186X (doi:10.1007/s00125-007-0790-1)

Packard, C.J. et al. (2007) Association between apolipoprotein E4 and cognitive decline in elderly adults. Journal of the American Geriatrics Society, 55 (11). pp. 1777-1785. ISSN 0002-8614 (doi:10.1111/j.1532-5415.2007.01415.x)

Al-Shayji, I.A., Gill, J.M.R., Cooney, J., Siddiqui, S., and Caslake, M.J. (2007) Development of a novel method to determine very low density lipoprotein kinetics. Journal of Lipid Research, 48 . pp. 2086-2095. ISSN 0022-2275 (doi:10.1194/jlr.D600044-JLR200)

Gill, J.M., Al-Mamari, A., Ferrell, W.R., Cleland, S.J., Perry, C.G., Sattar, N., Packard, C.J., Caslake, M.J., and Petrie, J.R. (2007) Effect of prior moderate exercise on postprandial metabolism in men with type 2 diabetes: Heterogeneity of responses. Atherosclerosis, 194 (1). pp. 134-143. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2006.10.007)

Lara, J.J., Economou, M., Wallace, A.M., Rumley, A., Lowe, G., Slater, C., Caslake, M., Sattar, N., and Lean, M.E.J. (2007) Benefits of salmon eating on traditional and novel vascular risk factors in young, non-obese healthy subjects. Atherosclerosis, 193 (1). pp. 213-221. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2006.06.018)

Geberhiwot, T., Alger, S., McKiernan, P., Packard, C., Caslake, M., Elias, E., and Cramb, R. (2007) Serum lipid and lipoprotein profile of patients with glycogen storage disease types I, III and IX. Journal of Inherited Metabolic Disease, 30 (3). p. 406. ISSN 0141-8955 (doi:10.1007/s10545-007-0485-2)

Sola, R. et al. (2007) Effects of soluble fiber (Plantago ovata husk) on plasma lipids, lipoproteins, and apolipoproteins in men with ischemic heart disease. American Journal of Clinical Nutrition, 85 (4). pp. 1157-1163. ISSN 0002-9165

Stewart, F.M., Freeman, D.J., Ramsay, J.E., Greer, I.A., Caslake, M., and Ferrell, W.R. (2007) Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothers. Journal of Clinical Endocrinology and Metabolism, 92 (3). pp. 969-975. ISSN 0021-972X (doi:10.1210/jc.2006-2083)

Adiels, M et al. (2007) Acute suppression of VLDL(1) secretion rate by insulin is associated with hepatic fat content and insulin resistance. Diabetologia, 50 (11). pp. 2356-2365.

Adiels, M. et al. (2006) Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia, 49 (4). pp. 755-765. ISSN 0012-186X (doi:10.1007/s00125-005-0125-z)

O'Reilly, D., Upton, M.N., Caslake, M.J., Robertson, M., Norrie, J., McConnachie, A., Watt, G.C.M., and Packard, C.J. (2006) Plasma C reactive protein concentration indicates a direct relation between systemic inflammation and social deprivation. Heart, 92 (4). pp. 533-535. ISSN 1355-6037 (doi:10.1136/hrt.2005.063081)

Hayek, T., Stephens, J.W., Hubbart, C.S., Acharya, J., Caslake, M.J., Hawe, E., Miller, G.J., Hurel, S.J., and Humphries, S.E. (2006) A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus. Atherosclerosis, 184 (2). pp. 404-412. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2005.05.017)

Gill, JM, Al-Mamari, A, Ferrell, WR, Cleland, SJ, Sattar, N, Packard, CJ, Petrie, JR, and Caslake, MJ (2006) Effects of a moderate exercise session on postprandial lipoproteins, apolipoproteins and lipoprotein remnants in middle-aged men. Atherosclerosis, 185 (1). pp. 87-96. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2005.06.009)

Lundahl, B., Skoglund-Andersson, C., Caslake, M., Bedford, D., Stewart, P., Hamsten, A., Packard, C.J., and Karpe, F. (2006) Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles. American Journal of Physiology: Endocrinology and Metabolism, 290 (4). E739-E745. ISSN 0193-1849 (doi:10.1152/ajpendo.00376.2005)

Belo, L., Santos-Silva, A., Caslake, M., Pereira-Leite, L., Quintanilha, A., and Rebelo, I. (2005) Oxidized-LDL levels in normal and pre-eclamptic pregnancies: Contribution of LDL particle size. Atherosclerosis, 183 (1). pp. 185-186. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2005.06.028)

Adiels, M, Packard, C, Caslake, M, Stewart, P, Soro, A, Westerbacka, J, Wennberg, B, Olofsson, SO, Taskinen, MR, and Boren, J (2005) A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions. Journal of Lipid Research, 46 (1). pp. 58-67.

Adiels, M., Boren, J., Caslake, M., Stewart, P., Soro, A., Westerbacka, J., Wennberg, B., Olofsson, S.O., Packard, C., and Taskinen, M.R. (2005) Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia. Arteriosclerosis, Thrombosis and Vascular Biology, 25 (8). pp. 1697-1703. ISSN 1079-5642

Belo, L., Santos-Silva, A., Rocha, S., Caslake, M., Cooney, J., Pereira-Leite, L., Quintanilha, A., and Rebelo, I. (2005) Fluctuations in C-reactive protein concentration and neutrophil activation during normal human pregnancy. European Journal of Obstetrics, Gynecology and Reproductive Biology, 123 . pp. 46-51. ISSN 0301-2115 (doi:10.1016/j.ejogrb.2005.02.022)

Caslake, M.J., and Packard, C.J. (2005) Lipoprotein-associated phospholipase A2 as a biomarker for coronary disease and stroke. Nature Clinical Practice Cardiovascular Medicine, 2 (10). pp. 529-535. ISSN 1743-4297 (doi:10.1038/ncpcardio0321)

Caslake, MJ, Gill, JMR, Higgins, S, Janilionyte, R, and Malkova, D (2005) Physical activity, dietary intake and metabolic risk factors in non-diabetic daughters of patients with type II diabetes. Preventive Medicine, 40 . pp. 145-151. (doi:10.1016/j.ypmed.2004.05.004)

Charakida, M et al. (2005) Early structural and functional changes of the vasculature in HIV-infected children - Impact of disease and antiretroviral therapy. Circulation, 112 . pp. 103-109. (doi:10.1161/CIRCULATIONAHA.104.5.17144)

Charakida, M et al. (2005) Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy. Circulation, 112 (1). pp. 103-109.

Stephens, JW, Sozen, MM, Whittall, RA, Caslake, MJ, Bedford, D, Acharya, J, Hurel, SJ, and Humphries, SE (2005) Three novel mutations in the apolipoprotein E gene in a sample of individuals with type 2 diabetes mellitus. Clinical Chemistry, 51 . pp. 119-124. (doi:10.1373/j.clinchem.2004.040121)

de Roos, B, Caslake, M, Milliner, K, Benson, GM, Suckling, KE, and Packard, CJ (2005) Characterisation of the lipoprotein structure in the St. Thomas' Mixed Hyperlipidaemic (SMHL) rabbit. Atherosclerosis, 181 (1). pp. 63-68. ISSN 0021-9150

Belo, L, Caslake, M, Santos-Silva, A, Castro, EM, Pereira-Leite, L, Quintanilha, A, and Rebelo, I (2004) LDL size, total antioxidant status and oxidised LDL in normal human pregnancy: a longitudinal study. Atherosclerosis, 177 . pp. 391-399. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2004.07.023)

Belo, L., Gaffney, D., Caslake, M., Santos-Silva, A., Pereira-Leite, L., Quintanilha, A., and Rebelo, I. (2004) Apolipoprotein E and cholesteryl ester transfer protein polymorphisms in normal and preeclamptic pregnancies. European Journal of Obstetrics, Gynecology and Reproductive Biology, 112 . pp. 9-15. ISSN 0301-2115 (doi:10.1016/S0301-2115(03)00240-9)

Caslake, M, and Packard, CJ (2004) Phenotypes, genotypes and response to statin therapy. Curr Opin Lipidol, 15 (4). pp. 387-392.

Chapman, MJ, and Caslake, M (2004) Non-high-density lipoprotein cholesterol as a risk factor: addressing risk associated with apolipoprotein B-containing lipoproteins. European Heart Journal Supplements, 6 (A). A43-A48.

Gill, J.M.R., Al-Mamari, A., Ferrell, W.R., Cleland, S.J., Packard, C.J., Sattar, N., Petrie, J.R., and Caslake, M.J. (2004) Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men. Journal of the American College of Cardiology, 44 (12). pp. 2375-2382. ISSN 0735-1097 (doi:10.1016/j.jacc.2004.09.035)

Gill, JM, Brown, JC, Bedford, D, Wright, DM, Cooney, J, Hughes, DA, Packard, CJ, and Caslake, M (2004) Hepatic production of VLDL(1) but not VLDL(2) is related to insulin resistance in normoglycaemic middle-aged subjects. Atherosclerosis, 176 (1). pp. 49-56. ISSN 0021-9150

Gill, JMR, Brown, JC, Bedford, D, Wright, DM, Cooney, J, Hughes, DA, Packard, CJ, and Caslake, MJ (2004) Hepatic production of VLDL1 but not VLDL2 is related to insulin resistance in normoglycaemic middle-aged subjects. Atherosclerosis, 176 . pp. 49-56. (doi:10.1016/j.atherosclerosis.2004.04.022)

Menys, VC, Liu, Y, Mackness, MI, Kwok, S, Caslake, M, Stewart, G, and Durrington, PN (2004) Isolation of plasma small-dense low-density lipoprotein using a simple air-driven ultracentrifuge and quantification using immunoassay of apolipoprotein B. Clinical Chemistry and Laboratory Medicine, 42 (1). pp. 30-36.

Rodie, VA, Caslake, MJ, Stewart, F, Sattar, N, Ramsay, JE, Greer, IA, and Freeman, DJ (2004) Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. Atherosclerosis, 176 . pp. 181-187. ISSN 0021-9150 (doi:10.1016/j.atherosclerosis.2004.04.026)

Belo, L, Santos-Silva, A, Caslake, M, Cooney, J, Pereira-Leite, L, Quintanilha, A, and Rebelo, I (2003) Neutrophil activation and C-reactive protein concentration in preeclampsia. Hypertension in Pregnancy, 22 . pp. 129-141. (doi:10.1081/PRG-120021059)

Caslake, M, and Packard, CJ (2003) Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease. Curr Opin Lipidol, 14 (4). pp. 347-352.

Caslake, M et al. (2003) Phenotype-dependent and -independent actions of rosuvastatin on atherogenic lipoprotein subfractions in hyperlipidaemia. Atherosclerosis, 171 (2). pp. 245-253. ISSN 0021-9150

Caslake, MJ, Ferrell, WR, Gill, JMR, Malkova, D, McAllister, C, Packard, CJ, and Tsofliou, F (2003) Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: Dissociation between changes in triglyceride metabolism and endothelial function. Journal of Clinical Endocrinology and Metabolism, 88 . pp. 4328-4335. (doi:10.1210/jc.2003-030226)

Chapman, MJ, Caslake, M, Packard, C, and McTaggart, F (2003) New dimension of statin action on ApoB atherogenicity. Clinical Cardiology, 26 (1 Supp). I7-10. ISSN 0160-9289

Freeman, DJ, Samani, NJ, Wilson, V, McMahon, AD, Braund, PS, Cheng, S, Caslake, MJ, Packard, CJ, and Gaffney, D (2003) A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study. European Heart Journal, 24 . pp. 1833-1842. (doi:10.1016/j.ehj.2003.07.001)

Gill, JM, Caslake, M, McAllister, C, Tsofliou, F, Ferrell, WR, Packard, CJ, and Malkova, D (2003) Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: dissociation between changes in triglyceride metabolism and endothelial function. j.gill@bio.gla.ac.uk. Journal of Clinical Endocrinology and Metabolism, 88 (9). pp. 4328-4335. ISSN 0021-972X

Kay, AD, Day, SP, Kerr, M, Nicoll, JA, Packard, CJ, and Caslake, MJ (2003) Remodeling of cerebrospinal fluid lipoprotein particles after human traumatic brain injury. Journal of Neurotrauma, 20 . pp. 717-723.

Kay, AD, Day, SP, Nicoll, JA, Packard, CJ, and Caslake, MJ (2003) Remodelling of cerebrospinal fluid lipoproteins after subarachnoid hemorrhage. Atherosclerosis, 170 . pp. 141-146. ISSN 0021-9150 (doi:10.1016/S0021-9150(03)00249-1)

Menys, VC, Liu, Y, Mackness, MI, Caslake, M, Kwok, S, and Durrington, PN (2003) Measurement of plasma small-dense LDL concentration by a simplified ultracentrifugation procedure and immunoassay of apolipoprotein B. Clinica Chimica Acta, 334 (01-Feb). pp. 95-106. ISSN 0009-8981

Muriithi, E.W., Belcher, P.R., Day, S., Chaudhry, M.A., Caslake, M.J., and Wheatley, D.J. (2002) Lipolysis generates platelet dysfunction after in vivo heparin administration. Clinical Science, 103 (4). pp. 433-440. ISSN 0143-5221

Belo, L, Caslake, M, Gaffney, D, Santos-Silva, A, Pereira-Leite, L, Quintanilha, A, and Rebelo, I (2002) Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies. Atherosclerosis, 162 (2). pp. 425-432. ISSN 0021-9150

Belo, L, Caslake, M, Santos-Silva, A, Pereira-Leite, L, Quintanilha, A, and Rebelo, I (2002) Lipoprotein(a): a longitudinal versus a cross-sectional study in normal pregnancy and its levels in preeclampsia. Atherosclerosis, 165 (2). pp. 393-395. ISSN 0021-9150

Cho, HK, Shin, G, Ryu, SK, Jang, Y, Day, SP, Stewart, G, Packard, CJ, Shepherd, J, and Caslake, MJ (2002) Regulation of small dense LDL concentration in Korean and Scottish men and women. Atherosclerosis, 164 . pp. 187-193. ISSN 0021-9150

Forster, LF, Stewart, G, Bedford, D, Stewart, JP, Rogers, E, Shepherd, J, Packard, CJ, and Caslake, M (2002) Influence of atorvastatin and simvastatin on apolipoprotein B metabolism in moderate combined hyperlipidemic subjects with low VLDL and LDL fractional clearance rates. Atherosclerosis, 164 (1). pp. 129-145. ISSN 0021-9150

Freeman, D.J., Norrie, J., Caslake, M.J., Gaw, A., Ford, I., Lowe, G.D.O., O'Reilly, D. St. J,, Packard, C.J., and Sattar, N. (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes, 51 (5). pp. 1596-1600. ISSN 0012-1797 (doi:10.2337/diabetes.51.5.1596)

Freeman, D.J., Norrie, J., Caslake, M.J., Gaw, A., Ford, I., Lowe, G.D.O., O'Reilly, D.S., Packard, C.J., and Sattar, N. (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes, 51 (5). pp. 1596-1600. ISSN 0012-1797

Gaffney, D, Forster, L, Caslake, M, Bedford, D, Stewart, JP, Stewart, G, Wieringa, G, Dominiczak, M, Miller, JP, and Packard, CJ (2002) Comparison of apolipoprotein B metabolism in familial defective apolipoprotein B and heterogeneous familial hypercholesterolemia. Atherosclerosis, 162 (1). pp. 33-43. ISSN 0021-9150

Muriithi, EW, Belcher, PR, Day, SP, Chaudhry, MA, Caslake, MJ, and Wheatley, DJ (2002) Lipolysis generates platelet dysfunction after in vivo heparin administration. Clinical Science, 103 . pp. 433-440.

Deighan, CJ, Caslake, M, McConnell, M, Boulton-Jones, JM, and Packard, CJ (2001) Comparative effects of cerivastatin and fenofibrate on the atherogenic lipoprotein phenotype in proteinuric renal disease. Journal of the American Society of Nephrology, 12 (2). pp. 341-348.

Deighan, CJ, Caslake, M, McConnell, M, Boulton-Jones, JM, and Packard, CJ (2001) The atherogenic lipoprotein phenotype: small dense LDL and lipoprotein remnants in nephrotic range proteinuria. Atherosclerosis, 157 (1). pp. 211-220. ISSN 0021-9150

Shahmanesh, M, Jaleel, H, DeSilva, Y, Ross, JD, Caslake, M, and Cramb, R (2001) Protease inhibitor related type III hyperlipoproteinaemia is common and not associated with apolipoprotein-E E2/E2 phenotype. Sexually Transmitted Infections, 77 . pp. 283-286.

de Roos, B, Caslake, M, Ardern, HA, Martin, BG, Suckling, KE, and Packard, CJ (2001) Insulin resistance in the St. Thomas' mixed hyperlipidaemic (SMHL) rabbit, a model for familial combined hyperlipidaemia. Atherosclerosis, 156 (2). pp. 249-254. ISSN 0021-9150

de Roos, B, Caslake, M, Stalenhoef, AF, Bedford, D, Demacker, PN, Katan, MB, and Packard, CJ (2001) The coffee diterpene cafestol increases plasma triacylglycerol by increasing the production rate of large VLDL apolipoprotein B in healthy normolipidemic subjects. American Journal of Clinical Nutrition, 73 (1). pp. 45-52. ISSN 0002-9165

Packard, C.J. et al. (2000) Lipoprotein-associated phospholipse A2 as an independent predictor of coronary heart disease (WOSCOPS). New England Journal of Medicine, 343 (16). pp. 1148-1155. ISSN 0028-4793 (doi:10.1056/NEJM200010193431603)

Packard, C.J. et al. (2000) Lipoprotein-associated phospholipase A(2) as an independent predictor of coronary heart disease. New England Journal of Medicine, 343 (16). pp. 1148-1155. ISSN 0028-4793

This list was generated on Wed Oct 2 01:22:09 2013 BST.

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Towards onset prevention of cognitive decline in adults with Down syndrome
    Scottish Executive Health Department
    2012 - 2014
     
  • Pilot Study of Analyses of Reykjavik Samples
    University of Cambridge
    2011 - 2011
     
  • Reykjavik Study Analysis.
    British Heart Foundation
    2009 - 2010
     
  • PHASE: A Pharmacogenomic Study of Statins in the Elderly at Risk for Cardiovascular Disease
    European Commission
    2009 - 2011
     
  • Effects of moderate exercise on very low density lipoprotein kinetics
    British Heart Foundation
    2006 - 2007
     
  • pSoBid - factors determing physical and mental well being in affluent and deprived communities in Glasgow
    Glasgow Centre for Population Health
    2006 - 2006
     
  • Are the effects of moderate exercise on postprandial metabolism influenced by energy deficit?
    Tenovus-Scotland
    2004 - 2006
     
  • The metabolic basis of dyslipidaemia in proteinuric renal disease
    The Future Forum
    2004 - 2005
     
  • Longitudinal assessment of vascular function throughout pregnancy and the puerperium - relationship of maternal body fat distribution to...
    British Medical Association
    2003 - 2006
     
  • Apolipoprotein E genotype and mechanisms of low density lipoprotein (LDL) cholesterol responses to the fish oil fatty acids
    BBSRC
    2003 - 2006
     
  • A role for novel candidate pathways in cerebrovascular disease and cognitive decline in the elderly?
    The Stroke Association
    2003 - 2005
     
  • Biochemical and physiological responsiveness to low dose fish oil intakes - impact of genotype, gender, age and geography
    Food Standards Agency
    2003 - 2006