- Professor of Clinical Pharmacology (Institute of Cardiovascular and Medical Sciences)
I am a CSO Clinician Scientist and Senior Lecturer within the division of Cardiovascular and Medical Sciences. My research interests involve the evaluation and treatment of disordered cerebral perfusion, and I run an active research programme in this area with 5 higher degree students currently under my supervision. Other research themes include the epidemiology of stroke disease, and outcome assessment after stroke.
Current projects include:
- Studies of the relationship between carotid plaque composition and biological behaviour using magnetic resonance imaging and transcranial Doppler ultrasound.
- Evaluation of reversibility of impaired cerebrovascular nitric oxide bioavailability in patients with diabetes.
- Examination of the effect of xanthine oxidase inhibition on the cerebral vasculature.
- A comprehensive evaluation of the impact of cerebrovascular disease in Scotland using the database of the Information and Statistics Division of the Scottish Executive.
- Evaluation of the potential impact of video-based outcome assessment (using the modified Rankin score) in clinical trials of novel stroke therapies.
Key collaborators in these projects include Professor Henry Dargie, Dr Graeme Houston, Professor Peter Langhorne, Professor Simon Capewell, Professor John McMurray and Dr Kate McIntyre.
My work is supported by sources which include the Chief Scientist Office, Chest Heart and Stroke Scotland, the Translational Medicine Research Collaboration. Income from competitive sources was approximately £600,000 in 2006-2007.
In addition to non-commercial studies I am local Principal Investigator for a number of multicentre clinical trials. Our centre currently leads the UK in recruitment for the ECASS 3 trial of alteplase in acute ischaemic stroke.