Institute of Cardiovascular and Medical Sciences

Dr Marie Freel

  • Clinical Senior Lecturer in Diabetes and Endocrinology (Institute of Cardiovascular and Medical Sciences)

telephone: 01413303412
email: Marie.Freel@glasgow.ac.uk


I am an MRC Clinician Scientist and Honorary Consultant Endocrinologist at the Western Infirmary, Glasgow. I received both undergraduate degrees from Glasgow University (BSc Honours 1996 and MBChB Honours 1999) and was awarded a PhD in 2006.

I was awarded a MRC Clinician Scientist Fellowship in 2009 for a programme of work entitled ‘Cardiovascular disease: investigating the expanding role of aldosterone.’ My principal research interest is in the role of corticosteroids (particularly aldosterone) in hypertension and cardiovascular disease.  My Fellowship comprises a series of translational studies examining further the influence of aldosterone on end-organ (cardiac and renal) damage as well as basic science studies exploring the genetic basis of hypertension with aldosterone excess. I am based within the BHF Glasgow Cardiovascular Research Centre and remain a member of the Blood Pressure Research Group led by Professors John Connell and Eleanor Davies.

I have developed collaborations with Dr Bill Young from Mayo Clinic, Rochester, Minnesota as well as leaders of the European Network for the Study of Adrenal Tumours (ENSAT; of which she is also a member). I sit on the Editorial Board of Clinical Science as well as the National Scientific Advisory Committee for Tenovus, Scotland.

List all by: Type | Date

Jump to: 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006
Number of items: 19.

2013

Delles, C., and Freel, E.M. (2013) Aldosterone, vascular endothelial growth factor, and preeclampsia: a mystery solved? Hypertension, 61 (5). pp. 958-960. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.00767)

Mark, P., Boyle, S., Zimmerli, L., McQuarrie, E., Delles, C., and Freel, E. (2013) Alterations in vascular function in primary aldosteronism - a cardiovascular magnetic resonance imaging study. Journal of Human Hypertension . ISSN 0950-9240 (doi:10.1038/jhh.2013.70)

McQuarrie, E.P., Freel, E.M., Mark, P.B., Fraser, R., Connell, J.M.C., and Jardine, A.G. (2013) Urinary sodium excretion is the main determinant of mineralocorticoid excretion rates in patients with chronic kidney disease. Nephrology, Dialysis, Transplantation, 28 (6). pp. 1526-1532. ISSN 0931-0509 (doi:10.1093/ndt/gft007)

2012

Freel, E.M., Mark, P.B., Weir, R.A.P., McQuarrie, E.P., Allan, K., Dargie, H.J., McClure, J.D., Jardine, A.G., Davies, E., and Connell, J.M.C. (2012) Demonstration of blood pressure-independent noninfarct myocardial fibrosis in primary aldosteronism: a cardiac magnetic resonance imaging study. Circulation: Cardiovascular Imaging, 5 (6). pp. 740-747. ISSN 1941-9651 (doi:10.1161/CIRCIMAGING.112.974576)

Davidson, D.F., Bradshaw, N., Perry, C.G., Lindsay, R., and Freel, E.M. (2012) Urinary free (unconjugated) metadrenalines in different hereditary forms of catecholamine-secreting phaeochromocytoma/paraganglioma. Annals of Clinical Biochemistry, 49 (5). pp. 486-490. ISSN 0004-5632 (doi:10.1258/acb.2012.012021)

McQuarrie, E.P., Freel, E.M., Mark, P.B., Fraser, R., Patel, R.K., Dargie, H.G., Connell, J.M.C., and Jardine, A.G. (2012) Urinary corticosteroid excretion predicts left ventricular mass and proteinuria in chronic kidney disease. Clinical Science, 123 (5). pp. 285-294. ISSN 0143-5221 (doi:10.1042/CS20120015)

Collier, A., Ghosh, S., Breckenridge, A., Perry, C.G., Freel, E.M., and Davidson, D.F. (2012) A phaeochromocytoma occurring in a patient with Parkinson’s disease on l-dopa therapy: a diagnostic challenge. Clinical Endocrinology, 76 (5). pp. 763-764. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2011.04266.x)

Currie, G., Freel, E.M., Perry, C.G., and Dominiczak, A.F. (2012) Disorders of blood pressure regulation — role of catecholamine biosynthesis, release, and metabolism. Current Hypertension Reports, 14 (1). pp. 38-45. ISSN 1522-6417 (doi:10.1007/s11906-011-0239-2)

2011

Yeap, P.M. et al. (2011) Molecular analysis of pheochromocytoma after maternal transmission of SDHD mutation elucidates mechanism of parent-of-origin effect. Journal of Clinical Endocrinology and Metabolism, 96 (12). E2009-E2013. ISSN 0021-972X (doi:10.1210/jc.2011-1244)

Alvarez-Madrazo, S., Connell, J, and Freel, E.M. (2011) Role of genetic variation in regulation of aldosterone biosynthesis. Endocrine Development, 20 (.). pp. 106-115. ISSN 1421–7082 (doi:10.1159/000321229)

2010

Freel, E. M. (2010) Pharmacogenetics: so near and yet so far? Journal of Hypertension, 28 (4). pp. 671-672. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833749fd Univ Glasgow, British Heart Fdn Glasgow, Cardiovasc Res Ctr, Glasgow G12 8TA, Lanark, Scotland.)

Freel, E.M., Stanson, A.W., Thompson, G.B., Grant, C.S., Farley, D.R., Richards, M.L., and Young, W.F. (2010) Adrenal Venous Sampling for Catecholamines: A Normal Value Study. Journal of Clinical Endocrinology and Metabolism, 95 (3). pp. 1328-1332. ISSN 0021-972X (doi:10.1210/jc.2009-2253)

2009

Freel, E.M., Tsorlalis, I.K., Lewsey, J.D., Latini, R., Maggioni, A.P., Solomon, S., Pitt, B., Connell, J.M.C., and McMurray, J.J.V. (2009) Aldosterone status associates with insulin resistance in patients with heart failure-data from the ALOFT study. Heart, 95 (23). pp. 1920-1924. ISSN 1355-6037 (doi:10.1136/hrt.2009.173344)

Davies, E., Davies, E., MacKenzie, S.M., MacKenzie, S., Freel, M., Alvarez-Madrazo, S., Fraser, R., and Connell, J. (2009) Altered corticosteroid biosynthesis in essential hypertension: a digenic phenomenon. Molecular and Cellular Endocrinology, 300 (1-2). pp. 185-191. ISSN 0303-7207 (doi:10.1016/j.mce.2008.09.014)

McManus, F, MacKenzie, SM, MacKenzie, S, and Freel, M. (2009) Central mineralocorticoid receptors, sympathetic activity, and hypertension. Current Hypertension Reports, 11 (3). pp. 224-230.

2008

Connell, J., MacKenzie, S.M., Freel, E.M., Fraser, R., and Davies, E. (2008) A lifetime of aldosterone excess: Long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocrine Reviews, 29 (2). pp. 133-154. ISSN 0163-769X (doi:10.1210/er.2007-0030 )

Freel, E.M., Ingram, M., Wallace, A.M., White, A., Fraser, R., Davies, E., and Connell, J. (2008) Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects. Clinical Endocrinology, 68 (5). pp. 700-706. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2007.03116.x )

2007

Thomson, AH, Devers, MC, Wallace, AM, Grant, D, Campbell, K, Freel, M, and Connell, JMC (2007) Variability in hydrocortisone plasma and saliva pharmacokinetics following intravenous and oral administration to patients with adrenal insufficiency. Clinical Endocrinology, 66 . pp. 789-796. (doi:10.1111/j.1365-2265.2007.02812.x)

2006

Imrie, H et al. (2006) Association between aldosterone production and variation in the 11 beta-hydroxylase (CYP11B1) gene. Journal of Clinical Endocrinology and Metabolism, 91 . pp. 5051-5056. (doi:10.1210/jc.2006-1481)

This list was generated on Tue Oct 1 19:46:16 2013 BST.
Jump to: Article
Number of items: 19.

Article

Delles, C., and Freel, E.M. (2013) Aldosterone, vascular endothelial growth factor, and preeclampsia: a mystery solved? Hypertension, 61 (5). pp. 958-960. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.00767)

Mark, P., Boyle, S., Zimmerli, L., McQuarrie, E., Delles, C., and Freel, E. (2013) Alterations in vascular function in primary aldosteronism - a cardiovascular magnetic resonance imaging study. Journal of Human Hypertension . ISSN 0950-9240 (doi:10.1038/jhh.2013.70)

McQuarrie, E.P., Freel, E.M., Mark, P.B., Fraser, R., Connell, J.M.C., and Jardine, A.G. (2013) Urinary sodium excretion is the main determinant of mineralocorticoid excretion rates in patients with chronic kidney disease. Nephrology, Dialysis, Transplantation, 28 (6). pp. 1526-1532. ISSN 0931-0509 (doi:10.1093/ndt/gft007)

Freel, E.M., Mark, P.B., Weir, R.A.P., McQuarrie, E.P., Allan, K., Dargie, H.J., McClure, J.D., Jardine, A.G., Davies, E., and Connell, J.M.C. (2012) Demonstration of blood pressure-independent noninfarct myocardial fibrosis in primary aldosteronism: a cardiac magnetic resonance imaging study. Circulation: Cardiovascular Imaging, 5 (6). pp. 740-747. ISSN 1941-9651 (doi:10.1161/CIRCIMAGING.112.974576)

Davidson, D.F., Bradshaw, N., Perry, C.G., Lindsay, R., and Freel, E.M. (2012) Urinary free (unconjugated) metadrenalines in different hereditary forms of catecholamine-secreting phaeochromocytoma/paraganglioma. Annals of Clinical Biochemistry, 49 (5). pp. 486-490. ISSN 0004-5632 (doi:10.1258/acb.2012.012021)

McQuarrie, E.P., Freel, E.M., Mark, P.B., Fraser, R., Patel, R.K., Dargie, H.G., Connell, J.M.C., and Jardine, A.G. (2012) Urinary corticosteroid excretion predicts left ventricular mass and proteinuria in chronic kidney disease. Clinical Science, 123 (5). pp. 285-294. ISSN 0143-5221 (doi:10.1042/CS20120015)

Collier, A., Ghosh, S., Breckenridge, A., Perry, C.G., Freel, E.M., and Davidson, D.F. (2012) A phaeochromocytoma occurring in a patient with Parkinson’s disease on l-dopa therapy: a diagnostic challenge. Clinical Endocrinology, 76 (5). pp. 763-764. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2011.04266.x)

Currie, G., Freel, E.M., Perry, C.G., and Dominiczak, A.F. (2012) Disorders of blood pressure regulation — role of catecholamine biosynthesis, release, and metabolism. Current Hypertension Reports, 14 (1). pp. 38-45. ISSN 1522-6417 (doi:10.1007/s11906-011-0239-2)

Yeap, P.M. et al. (2011) Molecular analysis of pheochromocytoma after maternal transmission of SDHD mutation elucidates mechanism of parent-of-origin effect. Journal of Clinical Endocrinology and Metabolism, 96 (12). E2009-E2013. ISSN 0021-972X (doi:10.1210/jc.2011-1244)

Alvarez-Madrazo, S., Connell, J, and Freel, E.M. (2011) Role of genetic variation in regulation of aldosterone biosynthesis. Endocrine Development, 20 (.). pp. 106-115. ISSN 1421–7082 (doi:10.1159/000321229)

Freel, E. M. (2010) Pharmacogenetics: so near and yet so far? Journal of Hypertension, 28 (4). pp. 671-672. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833749fd Univ Glasgow, British Heart Fdn Glasgow, Cardiovasc Res Ctr, Glasgow G12 8TA, Lanark, Scotland.)

Freel, E.M., Stanson, A.W., Thompson, G.B., Grant, C.S., Farley, D.R., Richards, M.L., and Young, W.F. (2010) Adrenal Venous Sampling for Catecholamines: A Normal Value Study. Journal of Clinical Endocrinology and Metabolism, 95 (3). pp. 1328-1332. ISSN 0021-972X (doi:10.1210/jc.2009-2253)

Freel, E.M., Tsorlalis, I.K., Lewsey, J.D., Latini, R., Maggioni, A.P., Solomon, S., Pitt, B., Connell, J.M.C., and McMurray, J.J.V. (2009) Aldosterone status associates with insulin resistance in patients with heart failure-data from the ALOFT study. Heart, 95 (23). pp. 1920-1924. ISSN 1355-6037 (doi:10.1136/hrt.2009.173344)

Davies, E., Davies, E., MacKenzie, S.M., MacKenzie, S., Freel, M., Alvarez-Madrazo, S., Fraser, R., and Connell, J. (2009) Altered corticosteroid biosynthesis in essential hypertension: a digenic phenomenon. Molecular and Cellular Endocrinology, 300 (1-2). pp. 185-191. ISSN 0303-7207 (doi:10.1016/j.mce.2008.09.014)

McManus, F, MacKenzie, SM, MacKenzie, S, and Freel, M. (2009) Central mineralocorticoid receptors, sympathetic activity, and hypertension. Current Hypertension Reports, 11 (3). pp. 224-230.

Connell, J., MacKenzie, S.M., Freel, E.M., Fraser, R., and Davies, E. (2008) A lifetime of aldosterone excess: Long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocrine Reviews, 29 (2). pp. 133-154. ISSN 0163-769X (doi:10.1210/er.2007-0030 )

Freel, E.M., Ingram, M., Wallace, A.M., White, A., Fraser, R., Davies, E., and Connell, J. (2008) Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects. Clinical Endocrinology, 68 (5). pp. 700-706. ISSN 0300-0664 (doi:10.1111/j.1365-2265.2007.03116.x )

Thomson, AH, Devers, MC, Wallace, AM, Grant, D, Campbell, K, Freel, M, and Connell, JMC (2007) Variability in hydrocortisone plasma and saliva pharmacokinetics following intravenous and oral administration to patients with adrenal insufficiency. Clinical Endocrinology, 66 . pp. 789-796. (doi:10.1111/j.1365-2265.2007.02812.x)

Imrie, H et al. (2006) Association between aldosterone production and variation in the 11 beta-hydroxylase (CYP11B1) gene. Journal of Clinical Endocrinology and Metabolism, 91 . pp. 5051-5056. (doi:10.1210/jc.2006-1481)

This list was generated on Tue Oct 1 19:46:16 2013 BST.

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • MINeralocorticoid Dysregulation in Chronic Kidney Disease (MIND-CKD)
    Kidney Research UK
    2013 - 2015
     
  • The INSPIRE programme
    Academy of Medical Sciences
    2013 - 2015
     
  • Cardiovascular consequences of preeclampsia in women from the Generation Scotland: Scottish Family Health Study.
    Scottish Executive Health Department
    2012 - 2014
     
  • Translational studies on the role of corticosteroids in cardiovascular disease
    MRC
    2009 - 2014
     
  • Studies of genotype and intermediate corticosteroid phenotype in hypertension
    Wellcome Trust
    2003 - 2006