Dr Laura Denby
- Research Associate (Institute of Cardiovascular and Medical Sciences)
telephone: 01413302727
email: Laura.Denby@glasgow.ac.uk
2012
Flores, M., Work, L.M. , Douglas, K. , Denby, L. , Dominiczak, A.F. , Graham, D. , and Nicklin, S.A. (2012) Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor. Hypertension, 59 (2). pp. 300-307. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.111.177485)
Flores-Munoz, M., Work, L.M. , Douglas, K. , Denby, L. , Dominiczak, A.F. , Graham, D. , and Nicklin, S.A. (2012) Angiotensin (1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor. Hypertension, 59 (2). pp. 300-3007. ISSN 0194-911X
2011
Denby, L. et al. (2011) miR-21 and miR-214 are consistently modulated during renal injury in rodent models. American Journal of Pathology, 179 (2). pp. 661-672. ISSN 0002-9440 (doi:10.1016/j.ajpath.2011.04.021)
2010
Greig, J.A., Shirley, R. , Graham, D. , Denby, L. , Dominiczak, A.F. , Work, L.M. , and Baker, A. (2010) Vascular-targeting anti-oxidant therapy in a model of hypertension and stroke. Journal of Cardiovascular Pharmacology, 56 (6). pp. 642-650. ISSN 0160-2446 (doi:10.1097/FJC.0b013e3181f8f19f)
Alba, R. et al. (2010) Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. Blood, 14 (116). pp. 2656-2664. ISSN 0006-4971 (doi:10.1182/blood-2009-12-260026)
Caruso, P. et al. (2010) Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arteriosclerosis, Thrombosis, and Vascular Biology, 30 (4). pp. 716-723. ISSN 1079-5642 (doi:10.1161/ATVBAHA.109.202028)
Greig, J.A., Shirley, R. , Graham, D. , Denby, L. , Dominiczak, A.F. , Work, L.M. , and Baker, A.H. (2010) Vascular-Targeting Antioxidant Therapy in a Model of Hypertension and Stroke. Journal of Cardiovascular Pharmacology, 56 (6). pp. 642-650. ISSN 0160-2446 (doi:10.1097/FJC.0b013e3181f8f19f)
2009
Nicol, C.G., Denby, L. , Lopez-Franco, O. , Masson, R., Halliday, C.A., Nicklin, S.A. , Kritz, A. , Work, L.M. , and Baker, A.H. (2009) Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature. Febs Letters, 583 (12). pp. 2100-2107. ISSN 0014-5793 (doi:10.1016/j.febslet.2009.05.037)
Diaconu, I. et al. (2009) Serotype chimeric and fiber-mutated adenovirus Ad5/19p-HIT for targeting renal cancer and untargeting the liver. Human Gene Therapy, 20 (6). pp. 611-620. ISSN 1043-0342 (doi:10.1089/hum.2008.108)
Lenaerts, L, Mcvey, JH, Baker, AH , Denby, L , Nicklin, SA , Verbeken, E, and Naesens, L (2009) Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting. Journal of Gene Medicine, 11 (2). pp. 119-127. (doi:10.1002/jgm.1283)
2008
Waddington, S. et al. (2008) Adenovirus serotype 5 hexon mediates liver gene transfer. Cell, 132 (3). pp. 397-409. ISSN 0092-8674 (doi:10.1016/j.cell.2008.01.016)
Miller, A.M., Xu, D. , Asquith, D. , Denby, L. , Li, Y. , Sattar, N. , Baker, A.H. , McInnes, I.B. , and Liew, F.Y. (2008) IL-33 reduces the development of atherosclerosis. Journal of Experimental Medicine, 205 (2). pp. 339-346. ISSN 0022-1007 (doi:10.1084/jem.20071868)
Waddington, SN et al. (2008) A critical role for the adenovirus serotype 5 hexon in liver gene transfer. Human Gene Therapy, 19 (4). p. 40.
2007
Denby, L., Work, L.M. , Von Seggern, D.J., Wu, E., Mcvey, J.H., Nicklin, S.A. , and Baker, A.H. (2007) Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p. Molecular Therapy, 15 (9). pp. 1647-1654. ISSN 0006-4971 (doi:10.1038/sj.mt.6300214)
2006
Parker, A.L. et al. (2006) Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes in vitro and in vivo. Blood, 108 (8). pp. 2554-2561. ISSN 0006-4971 (doi:10.1182/blood-2006-04-008532)
Work, L.M. et al. (2006) Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses. Molecular Therapy, 13 (4). pp. 683-693. (doi:10.1016/j.ymthe.2005.11.013)
2005
Denby, L., Nicklin, S.A. , and Baker, A.H. (2005) Adeno-associated virus (AAV)-7 and-8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation. Gene Therapy, 12 . pp. 1534-1538. ISSN 0969-7128 (doi:10.1038/sj.gt.3302564)
2004
Denby, L., Work, L.M. , Graham, D. , Hsu, C., Von Seggern, D.J., Nicklin, S.A. , and Baker, A.H. (2004) Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo. Human Gene Therapy, 15 (11). pp. 1054-1064. ISSN 1043-0342
Work, L.M., Nicol, C.G. , Denby, L. , and Baker, A.H. (2004) In vivo biopanning: a methodological approach to identifying novel targeting ligands for delivery of biological agents to the vasculature. In: Fennell, J.P. and Baker, A.H. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular medicine (108). Humana Press, Totowa, NJ, USA, pp. 395-413. ISBN 9781588293237
2003
Dishart, K.L. et al. (2003) Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy. Journal of Molecular and Cellular Cardiology, 35 (7). pp. 739-748. ISSN 0022-2828 (doi:10.1016/S0022-2828(03)00136-6)
