Institute of Cardiovascular and Medical Sciences

Prof Kenneth Mccoll

Prof Kenneth E McColl
  • Professor of Gastroenterology (Institute of Cardiovascular and Medical Sciences)

telephone: 01412112641
email: Kenneth.McColl@glasgow.ac.uk


My research concerns the aetiology and pathogenesis of upper gastrointestinal disease.  This includes:

  • The aetiology of gastric cancer.  We have conducted numerous studies on the changes in gastric function and histology preceding and leading to gastric cancer.  This includes changes in gastric acid secretion, bacterial colonization and alteration in luminal nitrite and N-nitroso compound production arising from the entero-salivary recirculating of dietary nitrate.  Currently, we are focusing on the aetiology of the 20-year delay in development of gastric cancer in females versus males.  One hypothesis we have generated and are studying is a potential role of the different tissue iron status between males and females during the reproductive years. 
  • The aetiology of cancer of the gastric cardia.  We have shown that cancer of the most proximal cardia region of the stomach consists of two aetiologically distinct types.  One is similar to that of the more distal stomach and its incidence is falling.  The other is aetiologically similar to that of the distal oesophagus and is showing a marked rise in incidence with Scotland having the highest reported incidence in the world.  We are investigating the role of acid catalysed nitrosation chemistry arising when salivary nitrite derived from salivary nitrate encounters gastric acidic juice at the GO junction with generation of nitrosating species and nitric oxide.  We have developed novel probes for studying this chemistry at this anatomical site.
  • The aetiology of gastro-oesophageal disease.  The incidence of gastro-oesophageal disease is rising as is its major complication of oesophageal adenocarcinoma.  Most of this disease occurs close to the gastro-oesophageal junction.  We have developed novel probes which are allowing us to study the physiology at the gastro-oesophageal junction and these include high resolution manometry, high resolution pH and a probe for constantly documenting the precise location of the gastro-oesophageal junction relative to these other probes.

Our research comprises both laboratory based work including studies of nitrite chemistry based in the Gardiner Institute at the Western Infirmary and clinical investigative studies based in our Research Unit at Gartnavel General Hospital.

Our Research Group is funded by grants from the Scottish Executive, the World Cancer Research Fund and industry and have amounted to more then £10,000,000 over the past fifteen years.

Our group collaborates with Professor Tom Preston, Scottish Universities Environmental Research Centre and Professor Alan Crozier, Institute of Biomedical & Life Sciences, University of Glasgow.  We also collaborate with research groups in Japan, China, Iran, Norway and Cambridge University. 

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Number of items: 102.

2013

Lee, Y.Y., Whiting, J.G.H., Robertson, E.V., Derakhshan, M.H., Smith, D., and McColl, K.E.L. (2013) Measuring movement and location of the gastroesophageal junction: research and clinical implications. Scandinavian Journal of Gastroenterology, 48 (4). pp. 401-411. ISSN 0036-5521 (doi:10.3109/00365521.2012.746394)

Kahrilas, P.J., McColl, K., Fox, M., O'Rourke, L., Sifrim, D., Smout, A.J.P.M., and Boeckxstaens, G. (2013) The acid pocket: a target for treatment in reflux disease? American Journal of Gastroenterology, 108 (7). pp. 1058-1064. ISSN 0002-9270 (doi:10.1038/ajg.2013.132)

Robertson, E.V., Derakhshan, M.H., Wirz, A.A., Lee, Y.Y., Seenan, J.P., Ballantyne, S.A., Hanvey, S.S., Kelman, A.W., Going, J.J., and McColl, K.E.L. (2013) Central obesity in asymptomatic volunteers is associated with increased intrasphincteric acid reflux and lengthening of the cardiac mucosa. Gastroenterology . ISSN 0016-5085 (doi:10.1053/j.gastro.2013.06.038) (In Press)

2012

Lee, Y.Y., Whiting, J.G.H., Robertson, E.V., Derakshan, M.H., Wirz, A.A., Smith, D., Morrison, D.J., Kelman, A.W., and McColl, K.E.L. (2012) Kinetics of transient hiatus hernia during transient lower esophageal sphincter relaxations and swallows in healthy subjects. Neurogastroenterology and Motility, 24 (11). pp. 990-998. ISSN 1350-1925 (doi:10.1111/j.1365-2982.2012.01948.x)

Seenan, J.P., Wirz, A.A., Robertson, E.V., Clarke, A.T., Manning, J.J., Kelman, A.W., Gillen, G., Ballantyne, S., Derakhshan, M.H., and McColl, K.L. (2012) Effect of nitrite delivered in saliva on postprandial gastro-esophageal function. Scandinavian Journal of Gastroenterology, 47 (4). pp. 387-396. ISSN 0036-5521 (doi:10.3109/00365521.2012.658854)

Derakhshan, M.H., Robertson, E.V., Fletcher, J., Jones, G.-R., Lee, Y.Y., Wirz, A.A., and McColl, K.E.L. (2012) Mechanism of association between BMI and dysfunction of the gastro-oesophageal barrier in patients with normal endoscopy. Gut, 61 (3). pp. 337-343. ISSN 0017-5749 (doi:10.1136/gutjnl-2011-300633)

Lee, Y.Y. et al. (2012) Development and validation of a probe allowing accurate and continuous monitoring of location of squamo-columnar junction. Medical Engineering and Physics, 34 (3). pp. 279-289. ISSN 1350-4533 (doi:10.1016/j.medengphy.2011.07.018)

Marek, A., McColl, K., Going, J., Spence, G., Jones, B., and Alexander, C. (2012) What a professor learned about Cyclospora cayetanensis by attending Digestive Diseases Week Conference in Chicago. American Journal of Gastroenterology, 107 (7). pp. 1109-1111. ISSN 0002-9270 (doi:10.1038/ajg.2012.74)

McColl, K.E.L. (2012) Serum IGF-1 linking visceral obesity with esophageal adenocarcinoma: unconvincing evidence. American Journal of Gastroenterology, 107 (2). pp. 205-206. ISSN 0002-9270 (doi:10.1038/ajg.2011.421)

McColl, K.E.L. (2012) The elegance of the gastric mucosal barrier: designed by nature for nature. Gut, 61 (6). pp. 787-788. ISSN 0017-5749 (doi:10.1136/gutjnl-2011-301612)

Whiting, J.G.H., Djennati, N., Lee, Y.Y., Robertson, E.V., Derakhshan, M.H., Connolly, P., and McColl, K.E.L. (2012) Towards minimally invasive monitoring for gastroenterology -An external Squamocolumnar Junction Locator. Conference Proceedings IEEE Engineering Medical Biology Society, 2012 . pp. 1574-1577. ISSN 1557-170X (doi:10.1109/EMBC.2012.6346244)

2011

Fletcher, J., Derakhshan, M.H., Jones, G.-R., Wirz, A.A., and McColl, K.E.L. (2011) BMI is superior to symptoms in predicting response to proton pump inhibitor: randomised trial in patients with upper gastrointestinal symptoms and normal endoscopy. Gut, 60 (4). pp. 442-448. ISSN 0017-5749 (doi:10.1136/gut.2010.228064)

Lochhead , P. et al. (2011) Association between a variation in the PSCA gene and upper gastrointestinal cancer in Caucasians. Gastroenterology, 140 (2). pp. 435-441. ISSN 0016-5085 (doi:10.1053/j.gastro.2010.11.001)

Lochhead, P. et al. (2011) Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals. Gastroenterology, 140 (2). pp. 435-441. ISSN 0016-5085 (doi:10.1053/j.gastro.2010.11.001)

Robertson, E.V., Lee, Y.Y., Derakhshan, M.H., Wirz, A.A., Whiting, J.R.H., Seenan, J.P., Connolly, P., and McColl, K.E.L. (2011) High-resolution esophageal manometry: addressing thermal drift of the manoscan system. Neurogastroenterology and Motility, 24 (1). 61-e11. ISSN 1350-1925 (doi:10.1111/j.1365-2982.2011.01817.x)

2010

Combet, E., El Mesmari, A., Preston, T., Crozier, A., and McColl, K.E.L. (2010) Dietary phenolic acids and ascorbic acid: influence on acid-catalyzed nitrosative chemistry in the presence and absence of lipids. Free Radical Biology and Medicine, 48 (6). pp. 763-771. ISSN 0891-5849 (doi:10.1016/j.freeradbiomed.2009.12.011)

Combet, E., Preston, T., and McColl, K. (2010) Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation. Rapid Communications in Mass Spectrometry, 24 (5). pp. 529-534. ISSN 0951-4198 (doi:10.1002/rcm.4388)

Freedman, N.D., Derakhshan, M.H., Abnet, C.C., Schatzkin, A., Hollenbeck, A.R., and McColl, K.E.L. (2010) Male predominance of upper gastrointestinal adenocarcinoma cannot be explained by differences in tobacco smoking in men versus women. European Journal of Cancer, 46 (13). pp. 2473-2478. ISSN 09598049 (doi:10.1016/j.ejca.2010.05.005)

Malfertheiner, P., McColl, K.E.L., and Chan, F. (2010) Peptic ulcer disease: further work is required to reduce inequalities – Authors' reply. Lancet, 375 (9714). p. 554. ISSN 0140-6736 (doi:10.1016/S0140-6736(10)60229-2)

McColl, K. E. L. (2010) Helicobacter pylori Infection. New England Journal of Medicine, 362 (17). pp. 1597-1604. ISSN 0028-4793

McColl, K. E. L., Clarke, A., and Seenan, J. (2010) Acid pocket, hiatus hernia and acid reflux. Gut, 59 (4). pp. 430-431. ISSN 0017-5749 (doi:10.1136/gut.2009.192922)

McColl, K. E. L., and Going, J. J. (2010) Aetiology and classification of adenocarcinoma of the gastro-oesophageal junction/cardia. Gut, 59 (3). pp. 282-284. ISSN 0017-5749 (doi:10.1136/gut.2009.186825)

Ng, M. T. H., van't Hof, R., Crockett, J. C., Hope, M. E., Berry, S., Thomson, J., McLean, M. H., McColl, K. E. L., El Omar, E. M., and Hold, G. L. (2010) Increase in NF-kappa B Binding Affinity of the Variant C Allele of the Toll-Like Receptor 9-1237T/C Polymorphism Is Associated with Helicobacter pylori-Induced Gastric Disease. Infection and Immunity, 78 (3). pp. 1345-1352. ISSN 0019-9567

2009

Clarke, A.T., Wirz, A.A,, Seenan, J.P., Manning, J.J., Gillen, D., and McColl, K.E.L. (2009) Paradox of gastric cardia: it becomes more acidic following meals while the rest of stomach becomes less acidic. Gut, 58 (7). pp. 904-909. ISSN 0017-5749 (doi:10.1136/gut.2008.161927)

Derakhshan, M.H., and McColl, K.E. (2009) Gender, hiatus hernia and Barrett's oesophagus. Gut, 58 (7). p. 1025. ISSN 0017-5749

Watabe, H., Mitsushima, T., Derakhshan, M.H., Yamaji, Y., Okamoto, M., Kawabe, T., Omata, M., and McColl, K.E.L. (2009) Study of Association Between Atrophic Gastritis and Body Mass Index: A Cross-Sectional Study in 10,197 Japanese Subjects. Digestive Diseases and Sciences, 54 (5). pp. 988-995. ISSN 0163-2116 (doi:10.1007/s10620-008-0468-7)

Derakhshan, M.H., Liptrot, S., Paul, J, Brown, I.L., Morrison, D.J., and McColl, K.E.L. (2009) Oesophageal and gastric intestinal-type adenocarcinomas show same male predominance - due to 17 year delayed development in females. Gut, 58 (1). pp. 16-23. ISSN 0017-5749 (doi:10.1136/gut.2008.161331 )

Lundberg, J.O et al. (2009) Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology, 5 (12). pp. 865-869. ISSN 1552-4450 (doi:10.1038/nchembio.260)

Malfertheiner, P, Chan, FKL, and McColl, KE (2009) Peptic ulcer disease. Lancet, 374 (9699). pp. 1449-1461.

McColl, KE (2009) Helicobacter pylori-Negative Nonsteroidal Anti-inflammatory Drug-Negative Ulcer. Gastroenterology Clinics of North America, 38 (2). 353-+.

McColl, KE (2009) How I Manage H-Pylori-Negative, NSAID/Aspirin-Negative Peptic Ulcers. American Journal of Gastroenterology, 104 (1). pp. 190-193. ISSN 0002-9270

McColl, KE, and Gillen, D (2009) Evidence That Proton-Pump Inhibitor Therapy Induces the Symptoms it Is Used to Treat. Gastroenterology, 137 (1). pp. 20-22.

2008

Derakhshan, M.H. et al. (2008) Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gatric cardia cancer. Gut, 57 (3). pp. 298-305. ISSN 0017-5749 (doi:10.1136/gut.2007.137364)

Clarke, AT, Wirz, AA, Manning, JJ, Ballantyne, SA, Alcorn, D, and McColl, KE (2008) Severe reflux disease is associated with an enlarged unbuffered proximal gastric acid pocket. Gut, 57 (3). p. 292. ISSN 0017-5749 (doi:10.1136/gut.2006.109421 )

McColl, KE, Watabe, H, and Derakhshan, MH (2008) Role of gastric atrophy in mediating negative association between Helicobacter pylori infection and reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma. Gut, 57 (6). pp. 721-723.

Tytgat, GN, McColl, KE, Tack, J, Holtmann, G, Hunt, RH, Malfertheiner, P, Hungin, APS, and Batchelor, HK (2008) New algorithm for the treatment of gastro-oesophageal reflux disease. Alimentary Pharmacology and Therapeutics, 27 (3). pp. 249-256. ISSN 0269-2813

2007

Combet, E., Paterson, S., Iijima, K., Winter, J., Mullen, W., Crozier, A., Preston, T., and McColl, K.E.L. (2007) Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation. Gut, 56 . pp. 1678-1684. ISSN 0017-5749 (doi:10.1136/gut.2007.128587)

McColl, KE, Watabe, H, and Derakhshan, MH (2007) Sporadic gastric cancer; a complex interaction of genetic and environmental risk factors. American Journal of Gastroenterology, 102 (9). pp. 1893-1895. ISSN 0002-9270

Hansen, S., Vollset, S.E., Derakhshan, M.H., Fyfe, V., Melby, K.K., Aase, S., Jellum, E., and McColl, K.E.L. (2007) Two distinct aetiologies of cardia cancer, evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status. Gut, 56 (7). pp. 918-925. ISSN 0017-5749 (doi:10.1136/gut.2006.114504)

Clemons, NJ, Fitzgerald, RC, and Mccoll, KEL (2007) Nitric oxide and acid induce double-strand DNA breaks in Barrett's esophagus carcinogenesis via distinct mechanisms. Gastroenterology, 133 . pp. 1198-1209. (doi:10.1053/j.gastro.2007.06.061)

Derakhshan, MH, Hansen, S, McColl, KE, and Vollset, SE (2007) Single aetiology and dual associations of cardiac cancer - Author's reply. Gut, 56 (10). pp. 1484-1485.

Fock, KM et al. (2007) Whistler summary: 'The slow rate of rapid progress'. Journal of Clinical Gastroenterology, 41 (6). pp. 539-545.

Fock, KM et al. (2007) Whistler Consensus. Journal of Clinical Gastroenterology, 41 (6). S47-S50.

Hold, GL et al. (2007) A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gastroenterology, 132 (3). pp. 905-912.

Manning, JJ, McColl, KE, and Wirz, AA (2007) Nitrogenous chemicals generated from acidification of saliva influence transient lower oesophageal sphincter relaxations. Scandinavian Journal of Gastroenterology, 42 (12). pp. 1413-1421.

McColl, K.E., Paterson, S., Preston, T., Scobie, G., Winter, J.W., and Wirz, A. (2007) N-nitrosamine generation from ingested nitrate via nitric oxide in subjects with and without gastroesophageal reflux. Gastroenterology, 133 (1). pp. 164-174. ISSN 0016-5085 (doi:10.1053/j.gastro.2007.04.047)

McColl, KE (2007) CON: Endoscopy is not necessary before treating Helicobacter pylori in patients with uncomplicated dyspepsia. American Journal of Gastroenterology, 102 (3). pp. 474-476. ISSN 0002-9270

McColl, KE (2007) Helicobacter pylori and oesophageal cancer - not always protective. Gut, 56 (4). pp. 457-459.

McColl, KEL (2007) Hostile environment of the gastroesophageal junction. Journal of Clinical Gastroenterology, 41 . S102-S107.

2006

Derakhshan, MH, El Omar, E, Oien, K, Gillen, D, Fyfe, V, Crabtree, JE, and McColl, KEL (2006) Gastric histology, serological markers and age as predictors of gastric acid secretion in patients infected with Helicobacter pylori. Journal of Clinical Pathology, 59 (12). pp. 1293-1299. ISSN 0021-9746 (doi:10.1136/jcp.2005.036111)

Casburn-Jones, AC, Murray, LS, Gillen, D, and McColl, KEL (2006) Endoscopy has minimal impact on mortality from upper gastrointestinal cancer in patients older than 55 years with uncomplicated dyspepsia. European Journal of Gastroenterology and Hepatology, 18 . pp. 645-648. ISSN 0954-691X

Gillen, D, and McColl, KE (2006) Effect of Helicobacter pylori eradication on precancerous lesions. Gut, 55 (7). p. 1054.

Gillen, D, and McColl, KE (2006) Is it safe to raise the age threshold for urgent endoscopy in patients with uncomplicated dyspepsia? Nature Clinical Practice Gastroenterology and Hepatology, 3 (8). pp. 424-425.

McColl, K.E.L., and Williams, C.L. (2006) Review article: proton pump inhibitors and bacterial overgrowth. Alimentary Pharmacology and Therapeutics, 23 . pp. 3-10. ISSN 0269-2813 (doi:10.1111/j.1365-2036.2006.02707)

McColl, KE (2006) Acid inhibitory medication and risk of gastric and oesophageal cancer. Gut, 55 (11). pp. 1532-1533.

McColl, KE (2006) Proton pump inhibitor therapy and Helicobacter pylori infection: A complicated relationship. Basic and Clinical Pharmacology and Toxicology, 99 (3). pp. 185-186.

McColl, KE, and Williams, C (2006) Gastric juice - a natural-born killer - Reply. Alimentary Pharmacology and Therapeutics, 23 (11). p. 1678. ISSN 0269-2813

McColl, KEL (2006) Cancer of the gastric cardia. Best Practice and Research: Clinical Gastroenterology, 20 . pp. 687-696. ISSN 1521-6918 (doi:10.1016/j.bpg.2006.03.005)

2005

Carswell, A, Fyffe, V, Henry, EB, Mccoll, KEL, and Wirz, A (2005) Proton pump inhibitors reduce the bioavailability of dietary vitamin C. Alimentary Pharmacology and Therapeutics, 22 . pp. 539-545. ISSN 0269-2813 (doi:10.1111/j.1365-2036.2005.02568.x)

Delaney, B, and McColl, K (2005) Review article: Helicobacter pylori and gastro-oesophageal reflux disease. Alimentary Pharmacology and Therapeutics, 22 . pp. 32-40. ISSN 0269-2813

Ford, AC, Qume, M, Moayyedi, P, Arents, NLA, Lassen, AT, Logan, RFA, McColl, KEL, Myres, P, and Delaney, BC (2005) Helicobacter pylori "test and treat" or endoscopy for managing dyspepsia: An individual patient data meta-analysis. Gastroenterology, 128 . pp. 1838-1844. (doi:10.1053/j.gastro.2005.03.004)

Fyfe, V, Iijima, K, McColl, KEL, Scobie, G, and Suzuki, H (2005) Nitrate and nitrosative chemistry within Barrett's oesophagus during acid reflux. Gut, 54 . pp. 1527-1535. (doi:10.1136/gut.2005.066043)

Gillen, D, and McColl, KEL (2005) Gastroduodenal disease, Helicobacter pylori and genetic polymorphisms. Clinical Gastroenterology and Hepatology, 3 . pp. 1180-1186.

Herrick, AL, and McColl, KEL (2005) Acute intermittent porphyria. Best Practice and Research: Clinical Gastroenterology, 19 . pp. 235-249. ISSN 1521-6918 (doi:10.1016/j.bpg.2004.10.006)

McColl, K.E.L., and Gillen, D. (2005) Prediction of malignant potential in reflux disease. American Journal of Gastroenterology, 100 (5). pp. 1019-1020. ISSN 0002-9270 (doi:10.1111/j.1572-0241.2005.41985.x)

McColl, KE (2005) Screening for early gastric cancer. Gut, 54 (6). pp. 740-742.

McColl, KEL (2005) When saliva meets acid: chemical warfare at the oesophagogastric junction. Gut, 54 . pp. 1-3. (doi:10.1136/gut.2004.047126)

2004

Derakhshan, MH, Yazdanbod, A, Sadjadi, AR, Shokoohi, B, McColl, KEL, and Malekzadeh, R (2004) High incidence of adenocarcinoma arising from the right side of the gastric cardia in NW Iran. Gut, 53 (9). pp. 1262-1266. ISSN 0017-5749 (doi:10.1136/gut.2003.035857)

Fletcher, J, Henry, E, McColl, KEL, and Wirz, A (2004) Studies of acid exposure immediately above the gastro-oesophageal squamocolumnar junction: evidence of short segment reflux. Gut, 53 . pp. 168-173.

Fletcher, J, and McColl, KE (2004) Short segment reflux: acid but no pocket? Reply. Gut, 53 (11). p. 1719.

Gillen, D, McColl, KEL, and Wirz, AA (2004) Helicobacter pylori eradication releases prolonged increased acid secretion following omeprazole treatment. Gastroenterology, 126 . pp. 980-988. (doi:10.1053/j.gastro.2004.01.004)

Kinoshita, Y., and McColl, K.E. (2004) Gastro-oesophageal reflux disease: A European and Japanese perspective - Introduction. Alimentary Pharmacology and Therapeutics, 20 . p. 1. ISSN 0269-2813

McColl, KE (2004) Helicobacter pylori infection and long term proton pump inhibitor therapy. Gut, 53 (1). pp. 5-7.

McColl, KE (2004) Rebound acid hypersecretion. Basic and Clinical Pharmacology and Toxicology, 94 (5). p. 201.

McColl, KEL (2004) Review article: Helicobacter pylori and gastro-oesophageal reflux disease - the European perspective. Alimentary Pharmacology and Therapeutics, 20 . pp. 36-39. ISSN 0269-2813

2003

Fletcher, J, Gillen, D, McColl, KE, and Wirz, A (2003) Barrett's esophagus evokes a quantitatively and qualitatively altered response to both acid and hypertonic solutions. American Journal of Gastroenterology, 98 (7). pp. 1480-1486. ISSN 0002-9270

Fyfe, V, Iijima, K, and McColl, KEL (2003) Studies of nitric oxide generation from salivary nitrite in human gastric juice. Scandinavian Journal of Gastroenterology, 38 . pp. 246-252. (doi:10.1080/00365520310000708)

Fyfe, V, Iijima, K, McColl, KEL, McElroy, K, Moriya, A, Scobie, G, and Suzuki, H (2003) Conditions for acid catalysed luminal nitrosation are maximal at the gastric cardia. Gut, 52 . pp. 1095-1101.

Fyfe, VE, Iijima, K, McColl, KEL, McElroy, K, Moriya, A, and Suzuki, H (2003) Validation of microdialysis probes for studying nitrosative chemistry within localized regions of the human upper gastrointestinal tract. Scandinavian Journal of Gastroenterology, 38 . pp. 856-863. (doi:10.1080/00365520310004119)

Iijima, K., Grant, J., McElroy, K., Fyfe, V., Preston, T., and McColl, K.E.L. (2003) Novel mechanism of nitrosative stress from dietary nitrate with relevance to gastro-oesophageal junction cancers. Carcinogenesis, 24 (12). pp. 1951-1960. ISSN 0143-3334 (doi:10.1093/carcin/bgg168)

McColl, KE (2003) Upper GI cancer in patients with uncomplicated dyspepsia. Scandinavian Journal of Gastroenterology, 38 (7). p. 804.

2002

Fletcher, J, and McColl, KE (2002) Evidence for pooling of gastric secretions in the proximal stomach in humans using single photon computed tomography - Reply. Gastroenterology, 123 (6). p. 2158.

Henry, E, Iijima, K, Kelman, AW, McColl, KEL, Moriya, A, and Wirz, A (2002) Dietary nitrate generates potentially mutagenic concentrations of nitric oxide at the gastroesophageal junction. Gastroenterology, 122 . pp. 1248-1257. (doi:10.1053/gast.2002.32963)

Kennerley, P, and McColl, KEL (2002) Proton pump inhibitors - differences emerge in hepatic metabolism. Digestive and Liver Disease, 34 . pp. 461-467.

McColl, KE (2002) Motion - Helicobacter pylori causes or worsens GERD: Arguments against the motion. Canadian Journal of Gastroenterology, 16 (9). pp. 615-617.

McNulty, C, Owen, R, Tompkins, D, Hawtin, P, McColl, K, Price, A, Smith, G, and Teare, L (2002) Helicobacter pylori susceptibility testing by disc diffusion. Journal of Antimicrobial Chemotherapy, 49 (4). pp. 601-609. ISSN 0305-7453 (doi:10.1093/jac/49.4.601)

Moriya, A., Grant, J., Mowat, C., Williams, C., Carswell, A., Anderson, S., Preston, T., Lijima, K., and McColl, K.E.M. (2002) In vitro studies indicate that acid catalysed generation of N-nitrosocompounds from dietary nitrate will be maximal at the gastro-oesophageal junction and cardia. Scandinavian Journal of Gastroenterology, 37 (3). pp. 253-261. ISSN 0036-5521 (doi:10.1080/003655202317284147)

2001

Fletcher, J, McColl, KEL, Vallance, R, Wirz, A, and Young, J (2001) Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal. Gastroenterology, 121 . pp. 775-783.

Gillen, D, Kidd, J, and McColl, KE (2001) Gastric cancer in patients with benign dyspepsia. Gut, 48 (4). pp. 581-582.

Gillen, D, and McColl, KE (2001) Helicobacter pylori and reflux disease. Lancet, 358 (9294). p. 1730.

Gillen, D, McColl, KE, and Neithercut, WD (2001) Re: Ammonia cannot explain the effect of H-pylori on omeprazole-induced acid suppression. American Journal of Gastroenterology, 96 (2). pp. 601-602. ISSN 0002-9270

Gillen, D, and McColl, KEL (2001) Problems associated with the clinical use of proton pump inhibitors. Pharmacology and Toxicology, 89 . pp. 281-286.

Gillen, D, and McColl, KEL (2001) Problems related to acid rebound and tachyphylaxis. Best Practice and Research: Clinical Gastroenterology, 15 . pp. 487-495. ISSN 1521-6918 (doi:10.1053/bega.2001.0190)

McColl, K, and Malfertheiner, P (2001) Helicobacter pylori and functional dyspepsia. Current Opinion in Gastroenterology, 16 . S29-S32.

McColl, KE (2001) H pylori and functional dyspepsia - Reply. Gut, 49 (5). p. 739.

McColl, KE (2001) Protagonist - Should we eradicate Helicobacter pylori in non-ulcer dyspepsia? Gut, 48 (6). pp. 759-761.

McColl, KE, and Murray, LS (2001) Testing for Helicobacter pylori in dyspeptic patients - Authors' strategy would leave many patients with ulcer uncured. British Medical Journal, 323 (7320). p. 1067. ISSN 0959-535X

McColl, KEL (2001) Review article: tackling the 'dyspeptic problem'. Alimentary Pharmacology and Therapeutics, 15 . pp. 10-13. ISSN 0269-2813

McColl, KEL, and Mowat, C (2001) Alterations in intragastric nitrite and vitamin C levels during acid inhibitory therapy. Best Practice and Research: Clinical Gastroenterology, 15 . pp. 523-537. ISSN 1521-6918

Woodward, N, Tunstall-Pedoe, H, and McColl, K (2001) Helicobacter pylori infection reduces systemic availability of dietary vitamin C. European Journal of Gastroenterology and Hepatology, 13 . pp. 233-237. ISSN 0954-691X

2000

El Omar, E.M. et al. (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature, 404 . pp. 398-402. ISSN 0028-0836 (doi:10.1038/35006081)

McColl, KEL (2000) Helicobacter pylori and dyspepsia. Pro and against. Digestive and Liver Disease, 32 . S199-S201.

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Number of items: 102.

Article

Lee, Y.Y., Whiting, J.G.H., Robertson, E.V., Derakhshan, M.H., Smith, D., and McColl, K.E.L. (2013) Measuring movement and location of the gastroesophageal junction: research and clinical implications. Scandinavian Journal of Gastroenterology, 48 (4). pp. 401-411. ISSN 0036-5521 (doi:10.3109/00365521.2012.746394)

Kahrilas, P.J., McColl, K., Fox, M., O'Rourke, L., Sifrim, D., Smout, A.J.P.M., and Boeckxstaens, G. (2013) The acid pocket: a target for treatment in reflux disease? American Journal of Gastroenterology, 108 (7). pp. 1058-1064. ISSN 0002-9270 (doi:10.1038/ajg.2013.132)

Robertson, E.V., Derakhshan, M.H., Wirz, A.A., Lee, Y.Y., Seenan, J.P., Ballantyne, S.A., Hanvey, S.S., Kelman, A.W., Going, J.J., and McColl, K.E.L. (2013) Central obesity in asymptomatic volunteers is associated with increased intrasphincteric acid reflux and lengthening of the cardiac mucosa. Gastroenterology . ISSN 0016-5085 (doi:10.1053/j.gastro.2013.06.038) (In Press)

Lee, Y.Y., Whiting, J.G.H., Robertson, E.V., Derakshan, M.H., Wirz, A.A., Smith, D., Morrison, D.J., Kelman, A.W., and McColl, K.E.L. (2012) Kinetics of transient hiatus hernia during transient lower esophageal sphincter relaxations and swallows in healthy subjects. Neurogastroenterology and Motility, 24 (11). pp. 990-998. ISSN 1350-1925 (doi:10.1111/j.1365-2982.2012.01948.x)

Seenan, J.P., Wirz, A.A., Robertson, E.V., Clarke, A.T., Manning, J.J., Kelman, A.W., Gillen, G., Ballantyne, S., Derakhshan, M.H., and McColl, K.L. (2012) Effect of nitrite delivered in saliva on postprandial gastro-esophageal function. Scandinavian Journal of Gastroenterology, 47 (4). pp. 387-396. ISSN 0036-5521 (doi:10.3109/00365521.2012.658854)

Derakhshan, M.H., Robertson, E.V., Fletcher, J., Jones, G.-R., Lee, Y.Y., Wirz, A.A., and McColl, K.E.L. (2012) Mechanism of association between BMI and dysfunction of the gastro-oesophageal barrier in patients with normal endoscopy. Gut, 61 (3). pp. 337-343. ISSN 0017-5749 (doi:10.1136/gutjnl-2011-300633)

Lee, Y.Y. et al. (2012) Development and validation of a probe allowing accurate and continuous monitoring of location of squamo-columnar junction. Medical Engineering and Physics, 34 (3). pp. 279-289. ISSN 1350-4533 (doi:10.1016/j.medengphy.2011.07.018)

Marek, A., McColl, K., Going, J., Spence, G., Jones, B., and Alexander, C. (2012) What a professor learned about Cyclospora cayetanensis by attending Digestive Diseases Week Conference in Chicago. American Journal of Gastroenterology, 107 (7). pp. 1109-1111. ISSN 0002-9270 (doi:10.1038/ajg.2012.74)

McColl, K.E.L. (2012) Serum IGF-1 linking visceral obesity with esophageal adenocarcinoma: unconvincing evidence. American Journal of Gastroenterology, 107 (2). pp. 205-206. ISSN 0002-9270 (doi:10.1038/ajg.2011.421)

McColl, K.E.L. (2012) The elegance of the gastric mucosal barrier: designed by nature for nature. Gut, 61 (6). pp. 787-788. ISSN 0017-5749 (doi:10.1136/gutjnl-2011-301612)

Whiting, J.G.H., Djennati, N., Lee, Y.Y., Robertson, E.V., Derakhshan, M.H., Connolly, P., and McColl, K.E.L. (2012) Towards minimally invasive monitoring for gastroenterology -An external Squamocolumnar Junction Locator. Conference Proceedings IEEE Engineering Medical Biology Society, 2012 . pp. 1574-1577. ISSN 1557-170X (doi:10.1109/EMBC.2012.6346244)

Fletcher, J., Derakhshan, M.H., Jones, G.-R., Wirz, A.A., and McColl, K.E.L. (2011) BMI is superior to symptoms in predicting response to proton pump inhibitor: randomised trial in patients with upper gastrointestinal symptoms and normal endoscopy. Gut, 60 (4). pp. 442-448. ISSN 0017-5749 (doi:10.1136/gut.2010.228064)

Lochhead , P. et al. (2011) Association between a variation in the PSCA gene and upper gastrointestinal cancer in Caucasians. Gastroenterology, 140 (2). pp. 435-441. ISSN 0016-5085 (doi:10.1053/j.gastro.2010.11.001)

Lochhead, P. et al. (2011) Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals. Gastroenterology, 140 (2). pp. 435-441. ISSN 0016-5085 (doi:10.1053/j.gastro.2010.11.001)

Robertson, E.V., Lee, Y.Y., Derakhshan, M.H., Wirz, A.A., Whiting, J.R.H., Seenan, J.P., Connolly, P., and McColl, K.E.L. (2011) High-resolution esophageal manometry: addressing thermal drift of the manoscan system. Neurogastroenterology and Motility, 24 (1). 61-e11. ISSN 1350-1925 (doi:10.1111/j.1365-2982.2011.01817.x)

Combet, E., El Mesmari, A., Preston, T., Crozier, A., and McColl, K.E.L. (2010) Dietary phenolic acids and ascorbic acid: influence on acid-catalyzed nitrosative chemistry in the presence and absence of lipids. Free Radical Biology and Medicine, 48 (6). pp. 763-771. ISSN 0891-5849 (doi:10.1016/j.freeradbiomed.2009.12.011)

Combet, E., Preston, T., and McColl, K. (2010) Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation. Rapid Communications in Mass Spectrometry, 24 (5). pp. 529-534. ISSN 0951-4198 (doi:10.1002/rcm.4388)

Freedman, N.D., Derakhshan, M.H., Abnet, C.C., Schatzkin, A., Hollenbeck, A.R., and McColl, K.E.L. (2010) Male predominance of upper gastrointestinal adenocarcinoma cannot be explained by differences in tobacco smoking in men versus women. European Journal of Cancer, 46 (13). pp. 2473-2478. ISSN 09598049 (doi:10.1016/j.ejca.2010.05.005)

Malfertheiner, P., McColl, K.E.L., and Chan, F. (2010) Peptic ulcer disease: further work is required to reduce inequalities – Authors' reply. Lancet, 375 (9714). p. 554. ISSN 0140-6736 (doi:10.1016/S0140-6736(10)60229-2)

McColl, K. E. L. (2010) Helicobacter pylori Infection. New England Journal of Medicine, 362 (17). pp. 1597-1604. ISSN 0028-4793

McColl, K. E. L., Clarke, A., and Seenan, J. (2010) Acid pocket, hiatus hernia and acid reflux. Gut, 59 (4). pp. 430-431. ISSN 0017-5749 (doi:10.1136/gut.2009.192922)

McColl, K. E. L., and Going, J. J. (2010) Aetiology and classification of adenocarcinoma of the gastro-oesophageal junction/cardia. Gut, 59 (3). pp. 282-284. ISSN 0017-5749 (doi:10.1136/gut.2009.186825)

Ng, M. T. H., van't Hof, R., Crockett, J. C., Hope, M. E., Berry, S., Thomson, J., McLean, M. H., McColl, K. E. L., El Omar, E. M., and Hold, G. L. (2010) Increase in NF-kappa B Binding Affinity of the Variant C Allele of the Toll-Like Receptor 9-1237T/C Polymorphism Is Associated with Helicobacter pylori-Induced Gastric Disease. Infection and Immunity, 78 (3). pp. 1345-1352. ISSN 0019-9567

Clarke, A.T., Wirz, A.A,, Seenan, J.P., Manning, J.J., Gillen, D., and McColl, K.E.L. (2009) Paradox of gastric cardia: it becomes more acidic following meals while the rest of stomach becomes less acidic. Gut, 58 (7). pp. 904-909. ISSN 0017-5749 (doi:10.1136/gut.2008.161927)

Derakhshan, M.H., and McColl, K.E. (2009) Gender, hiatus hernia and Barrett's oesophagus. Gut, 58 (7). p. 1025. ISSN 0017-5749

Watabe, H., Mitsushima, T., Derakhshan, M.H., Yamaji, Y., Okamoto, M., Kawabe, T., Omata, M., and McColl, K.E.L. (2009) Study of Association Between Atrophic Gastritis and Body Mass Index: A Cross-Sectional Study in 10,197 Japanese Subjects. Digestive Diseases and Sciences, 54 (5). pp. 988-995. ISSN 0163-2116 (doi:10.1007/s10620-008-0468-7)

Derakhshan, M.H., Liptrot, S., Paul, J, Brown, I.L., Morrison, D.J., and McColl, K.E.L. (2009) Oesophageal and gastric intestinal-type adenocarcinomas show same male predominance - due to 17 year delayed development in females. Gut, 58 (1). pp. 16-23. ISSN 0017-5749 (doi:10.1136/gut.2008.161331 )

Lundberg, J.O et al. (2009) Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology, 5 (12). pp. 865-869. ISSN 1552-4450 (doi:10.1038/nchembio.260)

Malfertheiner, P, Chan, FKL, and McColl, KE (2009) Peptic ulcer disease. Lancet, 374 (9699). pp. 1449-1461.

McColl, KE (2009) Helicobacter pylori-Negative Nonsteroidal Anti-inflammatory Drug-Negative Ulcer. Gastroenterology Clinics of North America, 38 (2). 353-+.

McColl, KE (2009) How I Manage H-Pylori-Negative, NSAID/Aspirin-Negative Peptic Ulcers. American Journal of Gastroenterology, 104 (1). pp. 190-193. ISSN 0002-9270

McColl, KE, and Gillen, D (2009) Evidence That Proton-Pump Inhibitor Therapy Induces the Symptoms it Is Used to Treat. Gastroenterology, 137 (1). pp. 20-22.

Derakhshan, M.H. et al. (2008) Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gatric cardia cancer. Gut, 57 (3). pp. 298-305. ISSN 0017-5749 (doi:10.1136/gut.2007.137364)

Clarke, AT, Wirz, AA, Manning, JJ, Ballantyne, SA, Alcorn, D, and McColl, KE (2008) Severe reflux disease is associated with an enlarged unbuffered proximal gastric acid pocket. Gut, 57 (3). p. 292. ISSN 0017-5749 (doi:10.1136/gut.2006.109421 )

McColl, KE, Watabe, H, and Derakhshan, MH (2008) Role of gastric atrophy in mediating negative association between Helicobacter pylori infection and reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma. Gut, 57 (6). pp. 721-723.

Tytgat, GN, McColl, KE, Tack, J, Holtmann, G, Hunt, RH, Malfertheiner, P, Hungin, APS, and Batchelor, HK (2008) New algorithm for the treatment of gastro-oesophageal reflux disease. Alimentary Pharmacology and Therapeutics, 27 (3). pp. 249-256. ISSN 0269-2813

Combet, E., Paterson, S., Iijima, K., Winter, J., Mullen, W., Crozier, A., Preston, T., and McColl, K.E.L. (2007) Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation. Gut, 56 . pp. 1678-1684. ISSN 0017-5749 (doi:10.1136/gut.2007.128587)

McColl, KE, Watabe, H, and Derakhshan, MH (2007) Sporadic gastric cancer; a complex interaction of genetic and environmental risk factors. American Journal of Gastroenterology, 102 (9). pp. 1893-1895. ISSN 0002-9270

Hansen, S., Vollset, S.E., Derakhshan, M.H., Fyfe, V., Melby, K.K., Aase, S., Jellum, E., and McColl, K.E.L. (2007) Two distinct aetiologies of cardia cancer, evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status. Gut, 56 (7). pp. 918-925. ISSN 0017-5749 (doi:10.1136/gut.2006.114504)

Clemons, NJ, Fitzgerald, RC, and Mccoll, KEL (2007) Nitric oxide and acid induce double-strand DNA breaks in Barrett's esophagus carcinogenesis via distinct mechanisms. Gastroenterology, 133 . pp. 1198-1209. (doi:10.1053/j.gastro.2007.06.061)

Derakhshan, MH, Hansen, S, McColl, KE, and Vollset, SE (2007) Single aetiology and dual associations of cardiac cancer - Author's reply. Gut, 56 (10). pp. 1484-1485.

Fock, KM et al. (2007) Whistler summary: 'The slow rate of rapid progress'. Journal of Clinical Gastroenterology, 41 (6). pp. 539-545.

Fock, KM et al. (2007) Whistler Consensus. Journal of Clinical Gastroenterology, 41 (6). S47-S50.

Hold, GL et al. (2007) A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gastroenterology, 132 (3). pp. 905-912.

Manning, JJ, McColl, KE, and Wirz, AA (2007) Nitrogenous chemicals generated from acidification of saliva influence transient lower oesophageal sphincter relaxations. Scandinavian Journal of Gastroenterology, 42 (12). pp. 1413-1421.

McColl, K.E., Paterson, S., Preston, T., Scobie, G., Winter, J.W., and Wirz, A. (2007) N-nitrosamine generation from ingested nitrate via nitric oxide in subjects with and without gastroesophageal reflux. Gastroenterology, 133 (1). pp. 164-174. ISSN 0016-5085 (doi:10.1053/j.gastro.2007.04.047)

McColl, KE (2007) CON: Endoscopy is not necessary before treating Helicobacter pylori in patients with uncomplicated dyspepsia. American Journal of Gastroenterology, 102 (3). pp. 474-476. ISSN 0002-9270

McColl, KE (2007) Helicobacter pylori and oesophageal cancer - not always protective. Gut, 56 (4). pp. 457-459.

McColl, KEL (2007) Hostile environment of the gastroesophageal junction. Journal of Clinical Gastroenterology, 41 . S102-S107.

Derakhshan, MH, El Omar, E, Oien, K, Gillen, D, Fyfe, V, Crabtree, JE, and McColl, KEL (2006) Gastric histology, serological markers and age as predictors of gastric acid secretion in patients infected with Helicobacter pylori. Journal of Clinical Pathology, 59 (12). pp. 1293-1299. ISSN 0021-9746 (doi:10.1136/jcp.2005.036111)

Casburn-Jones, AC, Murray, LS, Gillen, D, and McColl, KEL (2006) Endoscopy has minimal impact on mortality from upper gastrointestinal cancer in patients older than 55 years with uncomplicated dyspepsia. European Journal of Gastroenterology and Hepatology, 18 . pp. 645-648. ISSN 0954-691X

Gillen, D, and McColl, KE (2006) Effect of Helicobacter pylori eradication on precancerous lesions. Gut, 55 (7). p. 1054.

Gillen, D, and McColl, KE (2006) Is it safe to raise the age threshold for urgent endoscopy in patients with uncomplicated dyspepsia? Nature Clinical Practice Gastroenterology and Hepatology, 3 (8). pp. 424-425.

McColl, K.E.L., and Williams, C.L. (2006) Review article: proton pump inhibitors and bacterial overgrowth. Alimentary Pharmacology and Therapeutics, 23 . pp. 3-10. ISSN 0269-2813 (doi:10.1111/j.1365-2036.2006.02707)

McColl, KE (2006) Acid inhibitory medication and risk of gastric and oesophageal cancer. Gut, 55 (11). pp. 1532-1533.

McColl, KE (2006) Proton pump inhibitor therapy and Helicobacter pylori infection: A complicated relationship. Basic and Clinical Pharmacology and Toxicology, 99 (3). pp. 185-186.

McColl, KE, and Williams, C (2006) Gastric juice - a natural-born killer - Reply. Alimentary Pharmacology and Therapeutics, 23 (11). p. 1678. ISSN 0269-2813

McColl, KEL (2006) Cancer of the gastric cardia. Best Practice and Research: Clinical Gastroenterology, 20 . pp. 687-696. ISSN 1521-6918 (doi:10.1016/j.bpg.2006.03.005)

Carswell, A, Fyffe, V, Henry, EB, Mccoll, KEL, and Wirz, A (2005) Proton pump inhibitors reduce the bioavailability of dietary vitamin C. Alimentary Pharmacology and Therapeutics, 22 . pp. 539-545. ISSN 0269-2813 (doi:10.1111/j.1365-2036.2005.02568.x)

Delaney, B, and McColl, K (2005) Review article: Helicobacter pylori and gastro-oesophageal reflux disease. Alimentary Pharmacology and Therapeutics, 22 . pp. 32-40. ISSN 0269-2813

Ford, AC, Qume, M, Moayyedi, P, Arents, NLA, Lassen, AT, Logan, RFA, McColl, KEL, Myres, P, and Delaney, BC (2005) Helicobacter pylori "test and treat" or endoscopy for managing dyspepsia: An individual patient data meta-analysis. Gastroenterology, 128 . pp. 1838-1844. (doi:10.1053/j.gastro.2005.03.004)

Fyfe, V, Iijima, K, McColl, KEL, Scobie, G, and Suzuki, H (2005) Nitrate and nitrosative chemistry within Barrett's oesophagus during acid reflux. Gut, 54 . pp. 1527-1535. (doi:10.1136/gut.2005.066043)

Gillen, D, and McColl, KEL (2005) Gastroduodenal disease, Helicobacter pylori and genetic polymorphisms. Clinical Gastroenterology and Hepatology, 3 . pp. 1180-1186.

Herrick, AL, and McColl, KEL (2005) Acute intermittent porphyria. Best Practice and Research: Clinical Gastroenterology, 19 . pp. 235-249. ISSN 1521-6918 (doi:10.1016/j.bpg.2004.10.006)

McColl, K.E.L., and Gillen, D. (2005) Prediction of malignant potential in reflux disease. American Journal of Gastroenterology, 100 (5). pp. 1019-1020. ISSN 0002-9270 (doi:10.1111/j.1572-0241.2005.41985.x)

McColl, KE (2005) Screening for early gastric cancer. Gut, 54 (6). pp. 740-742.

McColl, KEL (2005) When saliva meets acid: chemical warfare at the oesophagogastric junction. Gut, 54 . pp. 1-3. (doi:10.1136/gut.2004.047126)

Derakhshan, MH, Yazdanbod, A, Sadjadi, AR, Shokoohi, B, McColl, KEL, and Malekzadeh, R (2004) High incidence of adenocarcinoma arising from the right side of the gastric cardia in NW Iran. Gut, 53 (9). pp. 1262-1266. ISSN 0017-5749 (doi:10.1136/gut.2003.035857)

Fletcher, J, Henry, E, McColl, KEL, and Wirz, A (2004) Studies of acid exposure immediately above the gastro-oesophageal squamocolumnar junction: evidence of short segment reflux. Gut, 53 . pp. 168-173.

Fletcher, J, and McColl, KE (2004) Short segment reflux: acid but no pocket? Reply. Gut, 53 (11). p. 1719.

Gillen, D, McColl, KEL, and Wirz, AA (2004) Helicobacter pylori eradication releases prolonged increased acid secretion following omeprazole treatment. Gastroenterology, 126 . pp. 980-988. (doi:10.1053/j.gastro.2004.01.004)

Kinoshita, Y., and McColl, K.E. (2004) Gastro-oesophageal reflux disease: A European and Japanese perspective - Introduction. Alimentary Pharmacology and Therapeutics, 20 . p. 1. ISSN 0269-2813

McColl, KE (2004) Helicobacter pylori infection and long term proton pump inhibitor therapy. Gut, 53 (1). pp. 5-7.

McColl, KE (2004) Rebound acid hypersecretion. Basic and Clinical Pharmacology and Toxicology, 94 (5). p. 201.

McColl, KEL (2004) Review article: Helicobacter pylori and gastro-oesophageal reflux disease - the European perspective. Alimentary Pharmacology and Therapeutics, 20 . pp. 36-39. ISSN 0269-2813

Fletcher, J, Gillen, D, McColl, KE, and Wirz, A (2003) Barrett's esophagus evokes a quantitatively and qualitatively altered response to both acid and hypertonic solutions. American Journal of Gastroenterology, 98 (7). pp. 1480-1486. ISSN 0002-9270

Fyfe, V, Iijima, K, and McColl, KEL (2003) Studies of nitric oxide generation from salivary nitrite in human gastric juice. Scandinavian Journal of Gastroenterology, 38 . pp. 246-252. (doi:10.1080/00365520310000708)

Fyfe, V, Iijima, K, McColl, KEL, McElroy, K, Moriya, A, Scobie, G, and Suzuki, H (2003) Conditions for acid catalysed luminal nitrosation are maximal at the gastric cardia. Gut, 52 . pp. 1095-1101.

Fyfe, VE, Iijima, K, McColl, KEL, McElroy, K, Moriya, A, and Suzuki, H (2003) Validation of microdialysis probes for studying nitrosative chemistry within localized regions of the human upper gastrointestinal tract. Scandinavian Journal of Gastroenterology, 38 . pp. 856-863. (doi:10.1080/00365520310004119)

Iijima, K., Grant, J., McElroy, K., Fyfe, V., Preston, T., and McColl, K.E.L. (2003) Novel mechanism of nitrosative stress from dietary nitrate with relevance to gastro-oesophageal junction cancers. Carcinogenesis, 24 (12). pp. 1951-1960. ISSN 0143-3334 (doi:10.1093/carcin/bgg168)

McColl, KE (2003) Upper GI cancer in patients with uncomplicated dyspepsia. Scandinavian Journal of Gastroenterology, 38 (7). p. 804.

Fletcher, J, and McColl, KE (2002) Evidence for pooling of gastric secretions in the proximal stomach in humans using single photon computed tomography - Reply. Gastroenterology, 123 (6). p. 2158.

Henry, E, Iijima, K, Kelman, AW, McColl, KEL, Moriya, A, and Wirz, A (2002) Dietary nitrate generates potentially mutagenic concentrations of nitric oxide at the gastroesophageal junction. Gastroenterology, 122 . pp. 1248-1257. (doi:10.1053/gast.2002.32963)

Kennerley, P, and McColl, KEL (2002) Proton pump inhibitors - differences emerge in hepatic metabolism. Digestive and Liver Disease, 34 . pp. 461-467.

McColl, KE (2002) Motion - Helicobacter pylori causes or worsens GERD: Arguments against the motion. Canadian Journal of Gastroenterology, 16 (9). pp. 615-617.

McNulty, C, Owen, R, Tompkins, D, Hawtin, P, McColl, K, Price, A, Smith, G, and Teare, L (2002) Helicobacter pylori susceptibility testing by disc diffusion. Journal of Antimicrobial Chemotherapy, 49 (4). pp. 601-609. ISSN 0305-7453 (doi:10.1093/jac/49.4.601)

Moriya, A., Grant, J., Mowat, C., Williams, C., Carswell, A., Anderson, S., Preston, T., Lijima, K., and McColl, K.E.M. (2002) In vitro studies indicate that acid catalysed generation of N-nitrosocompounds from dietary nitrate will be maximal at the gastro-oesophageal junction and cardia. Scandinavian Journal of Gastroenterology, 37 (3). pp. 253-261. ISSN 0036-5521 (doi:10.1080/003655202317284147)

Fletcher, J, McColl, KEL, Vallance, R, Wirz, A, and Young, J (2001) Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal. Gastroenterology, 121 . pp. 775-783.

Gillen, D, Kidd, J, and McColl, KE (2001) Gastric cancer in patients with benign dyspepsia. Gut, 48 (4). pp. 581-582.

Gillen, D, and McColl, KE (2001) Helicobacter pylori and reflux disease. Lancet, 358 (9294). p. 1730.

Gillen, D, McColl, KE, and Neithercut, WD (2001) Re: Ammonia cannot explain the effect of H-pylori on omeprazole-induced acid suppression. American Journal of Gastroenterology, 96 (2). pp. 601-602. ISSN 0002-9270

Gillen, D, and McColl, KEL (2001) Problems associated with the clinical use of proton pump inhibitors. Pharmacology and Toxicology, 89 . pp. 281-286.

Gillen, D, and McColl, KEL (2001) Problems related to acid rebound and tachyphylaxis. Best Practice and Research: Clinical Gastroenterology, 15 . pp. 487-495. ISSN 1521-6918 (doi:10.1053/bega.2001.0190)

McColl, K, and Malfertheiner, P (2001) Helicobacter pylori and functional dyspepsia. Current Opinion in Gastroenterology, 16 . S29-S32.

McColl, KE (2001) H pylori and functional dyspepsia - Reply. Gut, 49 (5). p. 739.

McColl, KE (2001) Protagonist - Should we eradicate Helicobacter pylori in non-ulcer dyspepsia? Gut, 48 (6). pp. 759-761.

McColl, KE, and Murray, LS (2001) Testing for Helicobacter pylori in dyspeptic patients - Authors' strategy would leave many patients with ulcer uncured. British Medical Journal, 323 (7320). p. 1067. ISSN 0959-535X

McColl, KEL (2001) Review article: tackling the 'dyspeptic problem'. Alimentary Pharmacology and Therapeutics, 15 . pp. 10-13. ISSN 0269-2813

McColl, KEL, and Mowat, C (2001) Alterations in intragastric nitrite and vitamin C levels during acid inhibitory therapy. Best Practice and Research: Clinical Gastroenterology, 15 . pp. 523-537. ISSN 1521-6918

Woodward, N, Tunstall-Pedoe, H, and McColl, K (2001) Helicobacter pylori infection reduces systemic availability of dietary vitamin C. European Journal of Gastroenterology and Hepatology, 13 . pp. 233-237. ISSN 0954-691X

El Omar, E.M. et al. (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature, 404 . pp. 398-402. ISSN 0028-0836 (doi:10.1038/35006081)

McColl, KEL (2000) Helicobacter pylori and dyspepsia. Pro and against. Digestive and Liver Disease, 32 . S199-S201.

This list was generated on Tue Oct 1 17:45:25 2013 BST.

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Does intra-abdominal fat accumulation induce intrasphincteric acid reflux and metaplasia at gastro-oesophageal junction?
    Scottish Executive Health Department
    2009 - 2012
     
  • Investigation of the influence of nitrite in saliva on gastro-oesophageal reflux
    Scottish Executive Health Department
    2007 - 2009
     
  • Influence of lipids on nN-nitrosative chemistry arising from dietary nitrate at the gastro-oesophagal junction
    World Cancer Research Fund
    2005 - 2008
     
  • Potential role of dietary nitrate in mutagenesis at the gastric cardia and within Barrett's oesophagus
    Scottish Executive Health Department
    2003 - 2005
     
  • The role of dietary nitrate in the aetiology of gastro-oesophageal junction adenocarcinoma
    MRC
    2003 - 2005
     

Professional Learned Society

  • 2006 - ongoing: Royal Society of Edinburgh - Elected Fellow (FRSE)
  • 2003 - ongoing: Royal College of Physicians of London - Fellow (FRCP)
  • 2000 - ongoing: Academy of Medical Sciences - Fellow (FMedSci)
  • 1987 - ongoing: Royal College of Physicians and Surgeons of Glasgow - Fellow (FRCP(Glas))