Professor Kennedy Lees

  • Professor of Cerebrovascular Medicine (Institute of Cardiovascular and Medical Sciences)
  • Associate (School of Medicine)

telephone: 01412112780
email: Kennedy.Lees@glasgow.ac.uk

Research interests

Prof Kennedy Lees is a clinical stroke researcher with a background in clinical pharmacology and cardiovascular medicine. His stroke service possesses independent carotid and vertebral Doppler, transcranial Doppler and CT scanning equipment and radiography/sonography staff.

He has extensive experience with protocol design and all stages of clinical development of neuroprotective compounds and thrombolytics.  He co-authored the influential STAIR statement on preclinical assessment of putative stroke treatments. He chaired the steering committee for the SAINT and CHANT programme with NXY-059. Prof Lees was also Principal Investigator for GAIN International and IMAGES trials.  He is UK coordinator and steering committee member for the SITS-MOST trial that proved safety of alteplase in routine clinical use. He has chaired independent data monitoring committees for the ASTIN and ICTUS neuroprotection trials, and for the DIAS, DEDAS and ECASS-III Trials with desmoteplase and alteplase. In secondary prevention, Prof Lees was joint regional Principal Investigator for the PROGRESS Trial and is UK chief investigator for the MRC-funded VITATOPS and industry-sponsored PERFORM Trials.

Design of clinical trials depends on relationships between entry criteria, baseline prognostic fators and outcome measures. Prof Lees founded the Virtual International Stroke Trials Archive (VISTA).  This resource of >20,000 patients’ data maximises value from patient participation in research.

Assessment of clinical outcome is crucial in trials. Prof Lees developed a DVD-based training and certification tool for the modified Rankin Scale, already in eight languages. His team is developing methods to strengthen outcome assessment further and has been responsible for advances in endpoint analysis approaches.

Highlighted text will link to original articles or websites in NEJM, Lancet, Stroke etc.

Research:

Clinical Trials:

Member:

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Access data sets contained within the Virtual International Stroke Trials Archive (VISTA)- ICH Database in order to perform analysis
    Pfizer Inc
    2014 - 2015
     
  • Xanthine oxidase inhibition for improvement of Long-term Outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST)
    Stroke Association
    2014 - 2019
     
  • MISTIE III
    National Institute of Health
    2013 - 2014
     
  • Robotic Therapy Early After Stroke Events (RTEASE).
    Chest, Heart & Stroke, Scotland
    2012 - 2015
     
  • EuroHyp
    European Commission
    2012 - 2017
     
  • Improving Acute and Rehabilitation Trial Design through Development and Investigation of a Clinical Trial Resource
    Scottish Executive Health Department
    2010 - 2013
     
  • Evaluation of electrocardiographic monitoring strategy to identify atrial fibrillation in patients with recent acute stroke
    Scottish Executive Health Department
    2010 - 2011
     
  • Clot Lysis: Evaluating Accelerated Resolution of IVH Phase III
    National Institute of Health
    2009 - 2013
     
  • The effect of allopurinol on carotid intima-media thickness and markers of endothelial function in patients with recent stroke - a pilot study
    The Stroke Association
    2009 - 2012
     
  • The Impact of Intraventricular Haemorrhage on Functional Outcomes and Economic Cost of Stroke.
    The Stroke Association
    2009 - 2010
     
  • Central adjudication of modified Rankin scale disability assessments in acute stroke trials
    Scottish Executive Health Department
    2009 - 2011
     
  • Improving the management of blood pressure in acute stroke - the efficacy of nitric oxide in stroke (ENOS) trial
    MRC
    2006 - 2011
     
  • Aspirin resistance and microemboli - towards targeted antiplatelet treatment
    Chest, Heart & Stroke, Scotland
    2006 - 2008
     
  • Magnesium in acute lacunar stroke patients - preliminary exploration of scientific hypothesis and implementation of optimal design procedure
    Scottish Executive Health Department
    2005 - 2006
     
  • Co-ordinating Centre for the UK Stroke Research Network
    Department of Health
    2005 - 2010
     
  • Co-ordinating Centre for the UK Stroke Research Network
    Department of Health
    2005 - 2015
     
  • Cerebrovascular nitric oxide bioavailability in type II diabetes
    Scottish Executive Health Department
    2005 - 2008
     
  • VITATOPS study - a randomised, double-blind, placebo-controlled trial of vitamins to prevent stroke
    MRC
    2003 - 2010
     
  • Caring for Informal Carers of Stroke Patients: The Development of an Evidence Based Intervention
    Chest, Heart & Stroke, Scotland
    2000 - 2009