- Professor of Cerebrovascular Medicine (Institute of Cardiovascular and Medical Sciences)
R208 Level 2
Glasgow G11 6NT
Prof Kennedy Lees is a clinical stroke researcher with a background in clinical pharmacology and cardiovascular medicine. His stroke service possesses independent carotid and vertebral Doppler, transcranial Doppler and CT scanning equipment and radiography/sonography staff.
He has extensive experience with protocol design and all stages of clinical development of neuroprotective compounds and thrombolytics. He co-authored the influential STAIR statement on preclinical assessment of putative stroke treatments. He chaired the steering committee for the SAINT and CHANT programme with NXY-059. Prof Lees was also Principal Investigator for GAIN International and IMAGES trials. He is UK coordinator and steering committee member for the SITS-MOST trial that proved safety of alteplase in routine clinical use. He has chaired independent data monitoring committees for the ASTIN and ICTUS neuroprotection trials, and for the DIAS, DEDAS and ECASS-III Trials with desmoteplase and alteplase. In secondary prevention, Prof Lees was joint regional Principal Investigator for the PROGRESS Trial and is UK chief investigator for the MRC-funded VITATOPS and industry-sponsored PERFORM Trials.
Design of clinical trials depends on relationships between entry criteria, baseline prognostic fators and outcome measures. Prof Lees founded the Virtual International Stroke Trials Archive (VISTA). This resource of >20,000 patients’ data maximises value from patient participation in research.
Assessment of clinical outcome is crucial in trials. Prof Lees developed a DVD-based training and certification tool for the modified Rankin Scale, already in eight languages. His team is developing methods to strengthen outcome assessment further and has been responsible for advances in endpoint analysis approaches.
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