Institute of Cardiovascular and Medical Sciences

Dr Ian Salt

  • Senior Lecturer (Institute of Cardiovascular and Medical Sciences)

telephone: 01413302049
email: Ian.Salt@glasgow.ac.uk


Signalling pathways that regulate nitric oxide production in endothelial cells and the role of AMP-activated protein kinase in the regulation of metabolism.

Research:

List all by: Type | Date

Jump to: 2013 | 2012 | 2011 | 2010 | 2008 | 2007 | 2005 | 2004 | 2003 | 2001 | 2000
Number of items: 23.

2013

MacKenzie, R.M. et al. (2013) Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. Clinical Science, 124 (6). pp. 403-411. ISSN 0143-5221 (doi:10.1042/CS20120239)

Salt, I.P. (2013) Examining the role of insulin in the regulation of cardiovascular health. Future Cardiology, 9 (1). pp. 39-52. ISSN 1479-6678 (doi:10.2217/fca.12.77)

Bijland, S., Mancini, S.J., and Salt, I.P. (2013) Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation. Clinical Science, 124 (8). pp. 491-507. ISSN 0143-5221 (doi:10.1042/CS20120536)

2012

Salt, I.P., and Palmer, T.M. (2012) Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opinion on Investigational Drugs, 21 (8). pp. 1155-1167. ISSN 1354-3784 (doi:10.1517/13543784.2012.696609)

2011

Boyle, J.G., Logan, P.J., Jones, G.C., Small, M., Sattar, N., Connell, J.M.C., Cleland, S.J., and Salt, I.P. (2011) AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study. Diabetologia, 54 (7). pp. 1799-1809. ISSN 0012-186X (doi:10.1007/s00125-011-2126-4)

Kohlhaas, C.F., Morrow, V.A., Jhakra, N., Patil, V., Connell, J.M.C., Petrie, J.R., and Salt, I.P. (2011) Insulin rapidly stimulates l-arginine transport in human aortic endothelial cells via Akt. Biochemical and Biophysical Research Communications, 412 (4). pp. 747-751. ISSN 0006-291X (doi:10.1016/j.bbrc.2011.08.048)

Reihill, J., Ewart, M.-A., and Salt, I.P. (2011) The role of AMP-activated protein kinase in the functional effects of vascular endothelial growth factor-A and -B in human aortic endothelial cells. Vascular Cell, 3 (1). p. 9. ISSN 2045-824X (doi:10.1186/2045-824X-3-9)

2010

Boyle, J.G., Salt, I.P., and McKay, G.A. (2010) Metformin action on AMP-activated protein kinase: a translational research approach to understanding a potential new therapeutic target. Diabetic Medicine, 27 (10). pp. 1097-1106. ISSN 0742-3071 (doi:10.1111/j.1464-5491.2010.03098.x)

Hall, L.M.L., Moran, C.N., Milne, G.R., MacFarlane, N.G., Forouhi, N.G., Hariharan, N., Salt, I.P., Sattar, N., and Gill, J.M.R. (2010) Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? PLoS ONE, 5 (12). e14197. ISSN 1932-6203 (doi:10.1371/journal.pone.0014197)

Ritchie, S.A., Kohlhaas, C.F., Boyd, A.R., Yalla, K.C., Walsh, K., Connell, J.M.C., and Salt, I.P. (2010) Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis. Biochemical Journal, 426 (1). pp. 85-90. ISSN 0264-6021 (doi:10.1042/BJ20091580)

2008

Ewart, M-A., Kohlhaas, C.F., and Salt, I.P. (2008) Inhibition of tumor necrosis factor α–stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase. Arteriosclerosis, Thrombosis and Vascular Biology, 28 (12). pp. 2255-2257. ISSN 1079-5642 (doi:10.1161/ATVBAHA.108.175919)

Boyle, J.G., Logan, P.J., Ewart, M.-A., Reihill, J.A., Ritchie, S.A., Connell, J.M.C., Cleland, S.J., and Salt, I.P. (2008) Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase. Journal of Biological Chemistry, 283 (17). pp. 11210-11217. ISSN 0021-9258 (doi:10.1074/jbc.M710048200)

2007

Reihill, J.A., Ewart, M.-A., Hardie, D.G., and Salt, I. (2007) AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production. Biochemical and Biophysical Research Communications, 354 (4). pp. 1084-1088. ISSN 0006-291X (doi:10.1016/j.bbrc.2007.01.110)

Kohlhaas, C., and Salt, I.P. (2007) Experimental hyperinsulinaemia does not alter insulin sensitivity of human endothelial cells or increase monocyte adhesion. Diabetic Medicine, 24 (S1). p. 40. ISSN 0742-3071 (doi:10.1111/j.1464-5491.2007.02126.x)

Reihill, JA, Ewart, MA, Hardie, DG, and Salt, IP (2007) AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production. Biochemical and Biophysical Research Communications, 354 . pp. 1084-1088. ISSN 0006-291X (doi:10.1016/j.bbrc.2007.01.110)

2005

Collison, M, James, DJ, Graham, D, Holman, GD, Connell, JMC, Dominiczak, A.F., Gould, GW, and Salt, IP (2005) Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats. Diabetologia, 48 (3). pp. 539-546. ISSN 0012-186X (doi:10.1007/s00125-005-1674-x)

2004

Ritchie, SA, Ewart, MA, Perry, CG, Connell, JMC, and Salt, IP (2004) The role of insulin and the adipocytokines in regulation of vascular endothelial function. Clinical Science, 107 (6). pp. 519-532. ISSN 0143-5221 (doi:10.1042/CS20040190)

2003

Morrow, VA, Foufelle, F, Connell, JMC, Petrie, John, Gould, GW, and Salt, IP (2003) Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. Journal of Biological Chemistry, 278 (34). pp. 31629-31639. ISSN 0021-9258 (doi:10.1074/jbc.M212831200)

Perry, CG, Palmer, T, Cleland, SJ, Morton, IJ, Salt, IP, Petrie, JR, Gould, GW, and Connell, JMC (2003) Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action. Clinical Science, 105 (2). pp. 187-194. ISSN 0143-5221 (doi:10.1042/CS20020320)

Salt, IP, Morrow, VA, Brandie, FM, Connell, JMC, and Petrie, JR (2003) High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser(1177) phosphorylation in human aortic endothelial cells. Journal of Biological Chemistry, 278 (21). pp. 18791-18797. ISSN 0021-9258 (doi:10.1074/jbc.M210618200)

2001

James, D.J., Cairns, F., Salt, I.P., Murphy, G.J., Dominiczak, A.F., Connell, J.M.C., and Gould, G.W. (2001) Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin. Diabetes, 50 (9). pp. 2148-2156. ISSN 0012-1797 (doi:10.2337/diabetes.50.9.2148 )

2000

Collison, M, Campbell, IW, Salt, IP, Dominiczak, AF, Connell, J, Lyall, H, and Gould, GW (2000) Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins. Diabetologia, 43 (11). pp. 1374-1380. ISSN 0012-186X (doi:10.1007/s001250051541)

Salt, IP, Connell, J, and Gould, GW (2000) 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Diabetes, 49 (10). pp. 1649-1656. ISSN 0012-1797 (doi:10.2337/diabetes.49.10.1649)

This list was generated on Tue Oct 1 11:58:34 2013 BST.
Jump to: Article
Number of items: 23.

Article

MacKenzie, R.M. et al. (2013) Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. Clinical Science, 124 (6). pp. 403-411. ISSN 0143-5221 (doi:10.1042/CS20120239)

Salt, I.P. (2013) Examining the role of insulin in the regulation of cardiovascular health. Future Cardiology, 9 (1). pp. 39-52. ISSN 1479-6678 (doi:10.2217/fca.12.77)

Bijland, S., Mancini, S.J., and Salt, I.P. (2013) Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation. Clinical Science, 124 (8). pp. 491-507. ISSN 0143-5221 (doi:10.1042/CS20120536)

Salt, I.P., and Palmer, T.M. (2012) Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opinion on Investigational Drugs, 21 (8). pp. 1155-1167. ISSN 1354-3784 (doi:10.1517/13543784.2012.696609)

Boyle, J.G., Logan, P.J., Jones, G.C., Small, M., Sattar, N., Connell, J.M.C., Cleland, S.J., and Salt, I.P. (2011) AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study. Diabetologia, 54 (7). pp. 1799-1809. ISSN 0012-186X (doi:10.1007/s00125-011-2126-4)

Kohlhaas, C.F., Morrow, V.A., Jhakra, N., Patil, V., Connell, J.M.C., Petrie, J.R., and Salt, I.P. (2011) Insulin rapidly stimulates l-arginine transport in human aortic endothelial cells via Akt. Biochemical and Biophysical Research Communications, 412 (4). pp. 747-751. ISSN 0006-291X (doi:10.1016/j.bbrc.2011.08.048)

Reihill, J., Ewart, M.-A., and Salt, I.P. (2011) The role of AMP-activated protein kinase in the functional effects of vascular endothelial growth factor-A and -B in human aortic endothelial cells. Vascular Cell, 3 (1). p. 9. ISSN 2045-824X (doi:10.1186/2045-824X-3-9)

Boyle, J.G., Salt, I.P., and McKay, G.A. (2010) Metformin action on AMP-activated protein kinase: a translational research approach to understanding a potential new therapeutic target. Diabetic Medicine, 27 (10). pp. 1097-1106. ISSN 0742-3071 (doi:10.1111/j.1464-5491.2010.03098.x)

Hall, L.M.L., Moran, C.N., Milne, G.R., MacFarlane, N.G., Forouhi, N.G., Hariharan, N., Salt, I.P., Sattar, N., and Gill, J.M.R. (2010) Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? PLoS ONE, 5 (12). e14197. ISSN 1932-6203 (doi:10.1371/journal.pone.0014197)

Ritchie, S.A., Kohlhaas, C.F., Boyd, A.R., Yalla, K.C., Walsh, K., Connell, J.M.C., and Salt, I.P. (2010) Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis. Biochemical Journal, 426 (1). pp. 85-90. ISSN 0264-6021 (doi:10.1042/BJ20091580)

Ewart, M-A., Kohlhaas, C.F., and Salt, I.P. (2008) Inhibition of tumor necrosis factor α–stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase. Arteriosclerosis, Thrombosis and Vascular Biology, 28 (12). pp. 2255-2257. ISSN 1079-5642 (doi:10.1161/ATVBAHA.108.175919)

Boyle, J.G., Logan, P.J., Ewart, M.-A., Reihill, J.A., Ritchie, S.A., Connell, J.M.C., Cleland, S.J., and Salt, I.P. (2008) Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase. Journal of Biological Chemistry, 283 (17). pp. 11210-11217. ISSN 0021-9258 (doi:10.1074/jbc.M710048200)

Reihill, J.A., Ewart, M.-A., Hardie, D.G., and Salt, I. (2007) AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production. Biochemical and Biophysical Research Communications, 354 (4). pp. 1084-1088. ISSN 0006-291X (doi:10.1016/j.bbrc.2007.01.110)

Kohlhaas, C., and Salt, I.P. (2007) Experimental hyperinsulinaemia does not alter insulin sensitivity of human endothelial cells or increase monocyte adhesion. Diabetic Medicine, 24 (S1). p. 40. ISSN 0742-3071 (doi:10.1111/j.1464-5491.2007.02126.x)

Reihill, JA, Ewart, MA, Hardie, DG, and Salt, IP (2007) AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production. Biochemical and Biophysical Research Communications, 354 . pp. 1084-1088. ISSN 0006-291X (doi:10.1016/j.bbrc.2007.01.110)

Collison, M, James, DJ, Graham, D, Holman, GD, Connell, JMC, Dominiczak, A.F., Gould, GW, and Salt, IP (2005) Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats. Diabetologia, 48 (3). pp. 539-546. ISSN 0012-186X (doi:10.1007/s00125-005-1674-x)

Ritchie, SA, Ewart, MA, Perry, CG, Connell, JMC, and Salt, IP (2004) The role of insulin and the adipocytokines in regulation of vascular endothelial function. Clinical Science, 107 (6). pp. 519-532. ISSN 0143-5221 (doi:10.1042/CS20040190)

Morrow, VA, Foufelle, F, Connell, JMC, Petrie, John, Gould, GW, and Salt, IP (2003) Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. Journal of Biological Chemistry, 278 (34). pp. 31629-31639. ISSN 0021-9258 (doi:10.1074/jbc.M212831200)

Perry, CG, Palmer, T, Cleland, SJ, Morton, IJ, Salt, IP, Petrie, JR, Gould, GW, and Connell, JMC (2003) Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action. Clinical Science, 105 (2). pp. 187-194. ISSN 0143-5221 (doi:10.1042/CS20020320)

Salt, IP, Morrow, VA, Brandie, FM, Connell, JMC, and Petrie, JR (2003) High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser(1177) phosphorylation in human aortic endothelial cells. Journal of Biological Chemistry, 278 (21). pp. 18791-18797. ISSN 0021-9258 (doi:10.1074/jbc.M210618200)

James, D.J., Cairns, F., Salt, I.P., Murphy, G.J., Dominiczak, A.F., Connell, J.M.C., and Gould, G.W. (2001) Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin. Diabetes, 50 (9). pp. 2148-2156. ISSN 0012-1797 (doi:10.2337/diabetes.50.9.2148 )

Collison, M, Campbell, IW, Salt, IP, Dominiczak, AF, Connell, J, Lyall, H, and Gould, GW (2000) Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins. Diabetologia, 43 (11). pp. 1374-1380. ISSN 0012-186X (doi:10.1007/s001250051541)

Salt, IP, Connell, J, and Gould, GW (2000) 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Diabetes, 49 (10). pp. 1649-1656. ISSN 0012-1797 (doi:10.2337/diabetes.49.10.1649)

This list was generated on Tue Oct 1 11:58:34 2013 BST.

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Regulation of the renin angiotension aldosterone system in adipose tissue by AMP-activated protein kinase
    Diabetes UK
    2013 - 2016
     
  • Mechanisms underlying the regulation of endothelial nitric oxide synthesis by glucose and insulin.
    Diabetes UK
    2013 - 2014
     
  • Inhibition of vascular Stat Signalling by Amp-Activated Protein Kinase (AMPK).
    British Heart Foundation
    2012 - 2015
     
  • The role of AMP-activated protein kinase in adipocyte glucose transport and insulin signalling - utilising a knockout mouse model
    Diabetes UK
    2012 - 2013
     
  • The sensitive assessment of the activity of cellular signalling pathways regulating insulin action and the cardiovascular complications of diabetes
    Diabetes UK
    2011 - 2014
     
  • The role of AMP-activated protein kinase in adipocyte glucose transport and insulin signalling
    Diabetes UK
    2010 - 2013
     
  • A pilot study of the effect of experimental hyperinsulinaemia on human endothelial cell nitric oxide synthase function
    Diabetes UK
    2008 - 2009
     
  • Type 2 diabetes research award prize
    Diabetes UK
    2008 - 2008
     
  • The role of the AMP activated protein kinase in adipocyte insulin action
    Tenovus-Scotland
    2007 - 2008
     
  • Impaired skeletal muscle oxidative capacity as a mechanism for greater insulin resistance in South Asians?
    Diabetes UK
    2007 - 2009
     
  • Regulation of endothelial nitric oxide synthesis by the AMP-activated protein kinase cascade
    British Heart Foundation
    2004 - 2007
     
  • Modulation and regulation of insulin-stimulated nitric oxide production in endothelial cells (Dr I P Salt)
    Diabetes UK
    2004 - 2007
     
  • The role of Tumour Necrosis Factor-alpha and Adiponectin in insulin-stimulated endothelial nitric oxide production
    MRC
    2004 - 2007
     
  • A biochemical investigation of the regulation of blood vessel growth and blood pressure
    Tenovus-Scotland
    2004 - 2005
     
  • The effects of metformin on vascular function and adipocyte AMPK activation in type 2 diabetes
    British Heart Foundation
    2004 - 2006
     

Editorial Board

  • 2011 - ongoing: ISRN Vascular Medicine

Grant Advisory Board

  • 2012 - ongoing: Diabetes Research and Wellness Foundation - Research Advisory Board Member
  • 2012 - ongoing: Diabetes UK - Research Grant Committee Member
  • 2010 - 2011: Diabetes UK - Member of Small Project Grant Committee
  • 2009 - 2011: Diabetes UK - Member of Science & Research Advisory Group
  • 2008 - 2011: Diabetes UK - Annual professional conference committee (Vice Chair 2009-2010; Chair 2010-2011)
  • 2006 - 2009: Diabetes UK - Member of Professional Advisory Council (Science & Research Working Group)
  • 2006 - 2013: Diabetes UK - Fellowships Interview Panel Member (2006, 2008, 2012, Chair 2013)
  • 2005 - 2009: Diabetes UK - Research Grant Committee Member
  • 2004 - 2009: MRC - Physiological Systems and Clinical Sciences Board (PSCSB) Special Review Panel
  • 2004 - 2009: MRC - College of Experts, Physiological Systems and Clinical Sciences Board

Invited International Presentations

  • 2012: Glasgow, Scotland, UK - Chair, 'Signalling and Diabetes' at Diabetes UK Annual Professional Conference 2012
  • 2011: London, UK - Chair of session "Genetics for everyone" at Diabetes UK Annual Professional Conference 2011
  • 2010: Liverpool, UK - Chair of 'Signalling' Session at the Diabetes UK Annual Professional Conference
  • 2009: Glasgow, Scotland - Chair 'Mechanisms and Implications of Vascular Dysfunction in Diabetes' at the Diabetes UK Annual Professional Conference
  • 2008: Glasgow, Scotland - Chair,'Regulation of Gene Expression' at the Diabetes UK Annual Professional Conference
  • 2006: London, UK - Invited Speaker at 197th Meeting of the Society for Endocrinology
  • 2005: Lund, Sweden - INYS workshop on diabetes and cardiovascular disease
  • 2004: Nice, France - Co-chair of the "Metabolic syndrome and Cardiovascular Risk" workshop at the 9th European Council for Cardiovascular Research Meeting

Professional Learned Society

  • 2012 - ongoing: Physiology Society - Member
  • 2010 - ongoing: British Society for Cell Biology - Member
  • 2009 - ongoing: European Association for the Study of Diabetes - Member
  • 2004 - 2010: American Diabetes Association - Member
  • 2003 - ongoing: Scottish Society for Experimental Medicine - Member
  • 1994 - ongoing: Biochemical Society - Member

Research Fellowship

  • 2004 - 2007: Diabetes UK RD Lawrence Fellowship
  • 2001 - 2004: British Heart Foundation Fellowship