2013

Kistler, A.D. et al. (2013) Urinary proteomic biomarkers for diagnosis and risk stratification of autosomal dominant polycystic kidney disease: a multicentric study. PLoS ONE, 8 (1). e53016. ISSN 1932-6203 (doi:10.1371/journal.pone.0053016)

Metzger, J. et al. (2013) Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders. Gut, 62 (1). pp. 122-130. ISSN 0017-5749 (doi:10.1136/gutjnl-2012-302047)

Mischak, H. (2013) How to get proteomics to the clinic? Issues in clinical proteomics, exemplified by CE-MS. Proteomics Clinical Applications, 6 (9-10). pp. 437-442. ISSN 1862-8346 (doi:10.1002/prca.201200027)

2012

Zurbig, P., Jerums, G., Hovind, P., MacIsaac, R.J., Mischak, H., Nielsen, S.E., Panagiotopoulos, S., Persson, F., and Rossing, P. (2012) Urinary proteomics for early diagnosis in diabetic nephropathy. Diabetes, 61 (12). pp. 3304-3313. ISSN 0012-1797 (doi:10.2337/db12-0348)

Molin, L. et al. (2012) A comparison between MALDI-MS and CE-MS data for biomarker assessment in chronic kidney diseases. Journal of Proteomics, 75 (18). pp. 5888-5897. ISSN 1874-3919 (doi:10.1016/j.jprot.2012.07.024)

von zur Muhlen, C. et al. (2012) Urine proteome analysis reflects atherosclerotic disease in an ApoE-/- mouse model and allows the discovery of new candidate biomarkers in mouse and human atherosclerosis. Molecular and Cellular Proteomics, 11 (7). M111.013847. ISSN 1535-9476 (doi:10.1074/mcp.M111.013847)

Mullen, W., Albalat, A., Gonzalez, J., Zerefos, P., Siwy, J., Franke, J., and Mischak, H. (2012) Performance of different separation methods interfaced in the same MS-reflection TOF detector: a comparison of performance between CE versus HPLC for biomarker analysis. Electrophoresis, 33 (4). pp. 567-574. ISSN 0173-0835 (doi:10.1002/elps.201100415)

Bandin, F., Siwy, J., Breuil, B., Mischak, H., Bascands, J., Decramer, S., and Schanstra, J.P. (2012) Urinary proteome analysis at 5-year followup of patients with nonoperated ureteropelvic junction obstruction suggests ongoing kidney remodeling. Journal of Urology, 187 (3). pp. 1006-1011. ISSN 0022-5347 (doi:10.1016/j.juro.2011.10.169)

Bandin, F., Siwy, J., Breuil, B., Mischak, H., Bascands, J.-L., Decramer, S., and Schanstra, J.P. (2012) Urinary proteome analysis at 5-Year follow up of patients with nonoperated ureteropelvic junction obstruction suggests ongoing kidney remodeling. Journal of Urology, 187 (3). pp. 1006-1011. ISSN 0022-5347 (doi:10.1016/j.juro.2011.10.169)

Dawson, J., Walters, M., Delles, C., Mischak, H., and Mullen, W. (2012) Urinary proteomics to support diagnosis of stroke. PLoS ONE, 7 (5). e35879. ISSN 1932-6203 (doi:10.1371/journal.pone.0035879)

Kuznetsova, T., Mischak, H., Mullen, W., and Staessen, J.A. (2012) Urinary proteome analysis in hypertensive patients with left ventricular diastolic dysfunction. European Heart Journal, 33 (18). pp. 2342-2350. ISSN 0195-668X (doi:10.1093/eurheartj/ehs185)

Mullen, W., Gonzalez, J., Siwy, J., Franke, J., Sattar, N., Mullan, A., Roberts, S., Delles, C., Mischak, H., and Albalat, A. (2012) A pilot study on the effect of short-term consumption of a polyphenol rich drink on biomarkers of coronary artery disease defined by urinary proteomics. Journal of Agricultural and Food Chemistry, 59 (24). pp. 12850-12857. ISSN 0021-8561 (doi:10.1021/jf203369r)

Rouse, R., Siwy, J., Mullen, W., Mischak, H., Metzger, J., and Hanig, J. (2012) Proteomic candidate biomarkers of drug-induced nephrotoxicity in the rat. PLoS ONE, 7 (4). e34606. ISSN 1932-6203 (doi:10.1371/journal.pone.0034606)

Siwy, J. et al. (2012) Evaluation of the zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles. PLoS ONE, 7 (12). e51334. ISSN 1932-6203 (doi:10.1371/journal.pone.0051334)

2011

Albalat, A., Mischak, H., and Mullen, W. (2011) Urine proteomics in clinical applications: technologies, principal considerations and clinical implementation. Prilozi, 32 (1). pp. 13-44. ISSN 0351-3254

Lankisch, T.O. et al. (2011) Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis. Hepatology, 53 (3). pp. 875-884. ISSN 0270-9139 (doi:10.1002/hep.24103)

Lopez, L.M., Mullen, W., Zürbig, P., Harris, S.E., Gow, A.J., Starr, J.M., Porteous, D.J., Mischak, H., and Deary, I.J. (2011) A pilot study of urinary peptides as biomarkers for intelligence in old age. Intelligence, 39 (1). pp. 46-53. ISSN 0160-2896 (doi:10.1016/j.intell.2010.11.001)

Albalat, A., Mischak, H., and Mullen, W. (2011) Clinical application of urinary proteomics/peptidomics. Expert Review of Proteomics, 8 (5). pp. 615-629. ISSN 1478-9450 (doi:10.1586/epr.11.46)

Carty, D.M. et al. (2011) Urinary proteomics for prediction of preeclampsia. Hypertension, 57 (3). pp. 561-569. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.110.164285)

Kistler, A.D. et al. (2011) A distinct urinary biomarker pattern characteristic of female fabry patients that mirrors response to enzyme replacement therapy. PLoS ONE, 6 (6). e20534. ISSN 1932-6203 (doi:10.1371/journal.pone.0020534)

Metzger, J. et al. (2011) Diagnosis of subclinical and clinical acute T-cell-mediated rejection in renal transplant patients by urinary proteome analysis. Proteomics Clinical Applications, 5 (5-6). pp. 322-333. ISSN 1862-8346 (doi:10.1002/prca.201000153)

Mischak, H., Thongboonkerd, V., Schanstra, J.P., and Vlahou, A. (2011) Renal and Urinary Proteomics. Proteomics Clinical Applications, 5 (5-6). pp. 211-213. ISSN 1862-8346 (doi:10.1002/prca.201190031)

Mullen, W., Delles, C., and Mischak, H. (2011) Urinary proteomics in the assessment of chronic kidney disease. Current Opinion in Nephrology and Hypertension, 20 (6). pp. 654-661. ISSN 1062-4821 (doi:10.1097/MNH.0b013e32834b7ffa)

2010

Mischak, H. et al. (2010) Recommendations for Biomarker Identification and Qualification in Clinical Proteomics. Science Translational Medicine, 2 (46). 46ps42--. ISSN 1946-6234 (doi:10.1126/scitranslmed.3001249)

Alkhalaf, A. et al. (2010) Multicentric validation of proteomic biomarkers in urine specific for diabetic nephropathy. PLoS ONE, 5 (10). e13421. ISSN 1932-6203 (doi:10.1371/journal.pone.0013421)

Dakna, M., Harris, K., Kalousis, A., Carpentier, S., Kolch, W., Schanstra, J.P., Haubitz, M., Vlahou, A., Mischak, H., and Girolami, M. (2010) Addressing the Challenge of Defining Valid Proteomic Biomarkers and Classifiers. BMC Bioinformatics, 11 (1). p. 594. ISSN 1471-2105 (doi:10.1186/1471-2105-11-594)

Delles, C. et al. (2010) Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. Journal of Hypertension, 28 (11). pp. 2316-2322. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833d81b7)

Fadini, G.P. et al. (2010) Urinary collagen fragments are significantly altered in diabetes: a link to pathophysiology. PLoS ONE, 5 (9). e13051. ISSN 1932-6203 (doi:10.1371/journal.pone.0013051)

Good, D. M. et al. (2010) Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease. Molecular and Cellular Proteomics, 9 (11). pp. 2424-2437. ISSN 1535-9476 (doi:10.1074/mcp.M110.001917)

Metzger, J., Kirsch, T., Schiffer, E., Ulger, P., Mentes, E., Brand, K., Weissinger, E.M., Haubitz, M., Mischak, H., and Herget-Rosenthal, S. (2010) Urinary excretion of twenty peptides forms an early and accurate diagnostic pattern of acute kidney injury. Kidney International, 78 (12). pp. 1252-1262. ISSN 0085-2538 (doi:10.1038/ki.2010.322)

Mischak, H., Delles, C., Klein, J., and Schanstra, J.P. (2010) Urinary Proteomics Based on Capillary Electrophoresis-Coupled Mass Spectrometry in Kidney Disease: Discovery and Validation of Biomarkers, and Clinical Application. Advances in Chronic Kidney Disease, 17 (6). pp. 493-506. ISSN 15485595 (doi:10.1053/j.ackd.2010.09.004)

Mischak, H. et al. (2010) Comprehensive human urine standards for comparability and standardization in clinical proteome analysis. Proteomics Clinical Applications, 4 (4). pp. 464-478. ISSN 1862-8346 (doi:10.1002/prca.200900189)

Mischak, H., and Rossing, P. (2010) Proteomic biomarkers in diabetic nephropathy--reality or future promise? Nephrology, Dialysis, Transplantation, 25 (9). pp. 2843-2845. ISSN 0931-0509 (doi:10.1093/ndt/gfq363)

Mischak, H., and Schanstra, J.P. (2010) CE-MS in biomarker discovery, validation, and clinical application. Proteomics Clinical Applications, 5 (1-2). pp. 9-23. ISSN 1862-8346 (doi:10.1002/prca.201000058)

2009

Dakna, M, He, Z., Yu, W.C., Mischak, H., and Kolch, W. (2009) Technical, bioinformatical and statistical aspects of liquid chromatography–mass spectrometry (LC–MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: A critical assessment. Journal of Chromatography B, 877 (13). pp. 1250-1258. ISSN 1570-0232 (doi:10.1016/j.jchromb.2008.10.048)

Dhillon, A.S., Yip, Y.Y., Grindlay, G.J., Pakay, J.L., Dangers, M., Hillmann, M., Clark, W., Pitt, A.R., Mischak, H., and Kolch, W. (2009) The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch. Cellular Signalling, 21 (11). pp. 1645-1651. ISSN 0898-6568 (doi:10.1016/j.cellsig.2009.07.001)

Harris, K., Girolami, M., and Mischak, H. (2009) Definition of valid proteomic biomarkers: a bayesian solution. Lecture Notes in Computer Science, 5780 . pp. 137-149. ISSN 0302-9743 (doi:10.1007/978-3-642-04031-3_13)

Mischak, H, Coon, JJ, Novak, J, Weissinger, EM, Schanstra, JP, and Dominiczak, AF (2009) Capillary Electrophoresis-Mass Spectrometry As A Powerful Tool in Biomarker Discovery and Clinical Diagnosis: An Update of Recent Developments. Mass Spectrometry Reviews, 28 (5). pp. 703-724. ISSN 0277-7037 (doi:10.1002/mas.20205 )

zur Muhlen, C et al. (2009) Evaluation of Urine Proteome Pattern Analysis for Its Potential To Reflect Coronary Artery Atherosclerosis in Symptomatic Patients. Journal of Proteome Research, 8 (1). pp. 335-345. ISSN 1535-3893 (doi:10.1021/pr800615t )

2008

Jantos-Siwy, J., Schiffer, E., Brand, K., Schumann, G., Rossing, K., Delles, C., Mischak, H., and Metzger, E. (2008) Quantitative urinary proteome analysis for biomarker evaluation in chronic kidney disease. Journal of Proteome Research, 8 (1). pp. 268-281. ISSN 1535-3893 (doi:10.1021/pr800401m)

Jiang, H. et al. (2008) Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proceedings of the National Academy of Sciences of the United States of America, 105 (32). pp. 11299-11304. ISSN 0027-8424 (doi:10.1073/pnas.0801457105)

Rossing, K., Mischak, H., Dakna, M., Zurbig, P., Novak, J., Julian, B. A., Good, D. M., Coon, J. J., Tarnow, L., and Rossing, P. (2008) Urinary Proteomics in Diabetes and CKD. Journal of the American Society of Nephrology, 19 (7). pp. 1283-1290. ISSN 1046-6673 (doi:10.1681/ASN.2007091025)

Coon, J.J. et al. (2008) CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics. Proteomics Clinical Applications, 2 (7-8). pp. 964-973. ISSN 1862-8346 (doi:10.1002/prca.200800024)

Zimmerli, L.U. et al. (2008) Urinary proteomic biomarkers on coronary artery disease. Molecular and Cellular Proteomics, 7 (2). pp. 290-298. ISSN 1535-9476 (doi:10.1074/mcp.M700394-MCP200)

2007

Mischak, H. (2007) Method and device for the qualitative and/or quantitative analysis of a protein and/or peptide pattern of a liquid sample that is derived from the human or animal body. .