Professor Harald Mischak

  • Robertson Chair in Biotechnology, Professor of Proteomics (Institute of Cardiovascular and Medical Sciences)

email: Harald.Mischak@glasgow.ac.uk

Institute of C&MS
BHF GCRC
Glasgow G12 8TA


Harald Mischak, holds a position as Professor for Proteomics and Systems Medicine at the University of Glasgow, and is the chief scientific officer of Mosaiques AG as well as executive director of Mosaiques diagnostics GmbH and DiaPat GmbH. With more than 180 peer reviewed manuscripts published on signaling and proteomics that have been cited over 11000 times (h-index 55), he is one of the leading experts worldwide in the field of proteome research and applied systems biology. Based on his experience on proteomics in basic research, he initiated the use of urinary proteomics and capillary electrophoresis coupled mass spectrometry for clinical application. Today he is a leading authority in clinical proteomics and biomarker identification. Among his achievement in this field are the development of guidelines for clinical proteome analysis, and the identification of proteomic biomarkers and biomarker-derived classifiers for a variety of diseases (e.g. cardiovascular disease, diabetes, chronic kidney disease, bladder and prostate cancer). Several of these are already in clinical use today. His main interest are the identification of additional biomarkers, and combining the knowledge on these with literature to establish models for molecular pathology, which would enable identification of appropriate therapeutic targets, and the implementation of “personalized medicine”.

List all by: Type | Date

Jump to: 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007
Number of items: 65.

2014

Siwy, J. et al. (2014) Multicentre prospective validation of a urinary peptidome-based classifier for the diagnosis of type 2 diabetic nephropathy. Nephrology, Dialysis, Transplantation, 29 (8). pp. 1563-1570. ISSN 0931-0509 (doi:10.1093/ndt/gfu039)

Husi, H., Van Agtmael, T., Mullen, W., Bahlmann, F. H., Schanstra, J. P., Vlahou, A., Delles, C., Perco, P., and Mischak, H. (2014) Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease. Circulation: Cardiovascular Genetics, 7 (2). pp. 161-170. ISSN 1942-325X (doi:10.1161/CIRCGENETICS.113.000196)

Klein, J., Papadopoulos, T., Mischak, H., and Mullen, W. (2014) Comparison of CE-MS/MS and LC-MS/MS sequencing demonstrates significant complementarity in natural peptide identification in human urine. Electrophoresis, 35 (7). pp. 1060-1064. ISSN 0173-0835 (doi:10.1002/elps.201300327)

Mullen, W., Saigusa, D., Abe, T., Adamski, J., and Mischak, H. (2014) Proteomics and metabolomics as tools to unravel novel culprits and mechanisms of uremic toxicity: instrument or hype? Seminars in Nephrology, 34 (2). pp. 180-190. ISSN 0270-9295 (doi:10.1016/j.semnephrol.2014.02.009)

Frantzi, M. et al. (2014) Discovery and validation of urinary biomarkers for detection of renal cell carcinoma. Journal of Proteomics, 98C . pp. 44-58. ISSN 1874-3919 (doi:10.1016/j.jprot.2013.12.010)

Klein, J., Buffin-Meyer, B., Mullen, W., Carty, D. M., Delles, C., Vlahou, A., Mischak, H., Decramer, S., Bascands, J.-L., and Schanstra, J. P. (2014) Clinical proteomics in obstetrics and neonatology. Expert Review of Proteomics, 11 (1). pp. 75-89. ISSN 1478-9450 (doi:10.1586/14789450.2014.872564)

Albalat, A., Husi, H., Stalmach, A., Schanstra, J. P., and Mischak, H. (2014) Classical MALDI-MS versus CE-based ESI-MS proteomic profiling in urine for clinical applications. Bioanalysis, 6 (2). pp. 247-66. ISSN 1757-6180 (doi:10.4155/bio.13.313)

Koss, M. J. et al. (2014) Proteomics of vitreous humor of patients with exudative age-related macular degeneration. PLoS ONE, 9 (5). e96895. ISSN 1932-6203 (doi:10.1371/journal.pone.0096895)

Nkuipou-Kenfack, E. et al. (2014) Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease. PLoS ONE, 9 (5). e96955. ISSN 1932-6203 (doi:10.1371/journal.pone.0096955)

2013

Albalat, A. et al. (2013) Improving peptide relative quantification in MALDI-TOF MS for biomarker assessment. Proteomics, 13 (20). pp. 2967-2975. ISSN 1615-9853 (doi:10.1002/pmic.201300100)

Frantzi, M. et al. (2013) IMAC fractionation in combination with LC–MS reveals H2B and NIF-1 peptides as potential bladder cancer biomarkers. Journal of Proteome Research, 12 (9). pp. 3969-3979. ISSN 1535-3893 (doi:10.1021/pr400255h)

Klein, J. et al. (2013) Fetal urinary peptides to predict postnatal outcome of renal disease in fetuses with posterior urethral valves(PUV). Science Translational Medicine, 5 (198). 198ra106. ISSN 1946-6234 (doi:10.1126/scitranslmed.3005807)

Mansor, R., Mullen, W., Albalat, A., Zerefos, P., Mischak, H., Barrett, D.C., Biggs, A., and Eckersall, P.D. (2013) A peptidomic approach to biomarker discovery for bovine mastitis. Journal of Proteomics, 85 . pp. 89-98. ISSN 1874-3919 (doi:10.1016/j.jprot.2013.04.027)

Stalmach, A., Albalat, A., Mullen, W., and Mischak, H. (2013) Recent advances in capillary electrophoresis coupled to mass spectrometry for clinical proteomic applications. Electrophoresis, 34 (11). pp. 1452-1464. ISSN 0173-0835 (doi:10.1002/elps.201200708)

Klein, J., Eales, J., Zürbig, P., Vlahou, A., Mischak, H., and Stevens, R. (2013) Proteasix: a tool for automated and large-scale prediction of proteases involved in naturally occurring peptide generation. Proteomics, 13 (7). pp. 1077-1082. ISSN 1615-9853 (doi:10.1002/pmic.201200493)

Mischak, H., Vlahou, A., and Ioannidis, J.P.A. (2013) Technical aspects and inter-laboratory variability in native peptide profiling: the CE–MS experience. Clinical Biochemistry, 46 (6). pp. 432-443. ISSN 0009-9120 (doi:10.1016/j.clinbiochem.2012.09.025)

Roscioni, S.S. et al. (2013) A urinary peptide biomarker set predicts worsening of albuminuria in type 2 diabetes mellitus. Diabetologia, 56 (2). pp. 259-267. ISSN 0012-186X (doi:10.1007/s00125-012-2755-2)

Dissard, R. et al. (2013) Long term metabolic syndrome induced by a high fat high fructose diet leads to minimal renal injury in C57BL/6 mice. PLoS ONE, 8 (10). e76703. ISSN 1932-6203 (doi:10.1371/journal.pone.0076703)

Husi, H., Sanchez-Niño, M., Delles, C., Mullen, W., Vlahou, A., Ortiz, A., and Mischak, H. (2013) A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI. BMC Systems Biology, 7 (110). ISSN 1752-0509 (doi:10.1186/1752-0509-7-110)

Kistler, A.D. et al. (2013) Urinary proteomic biomarkers for diagnosis and risk stratification of autosomal dominant polycystic kidney disease: a multicentric study. PLoS ONE, 8 (1). e53016. ISSN 1932-6203 (doi:10.1371/journal.pone.0053016)

Klein, G., Schanstra, J.P., Hoffmann, J., Mischak, H., Siwy, J., and Zimmermann, K. (2013) Proteomics as a quality control tool of pharmaceutical probiotic bacterial lysate products. PLoS ONE, 8 (6). e66682. ISSN 1932-6203 (doi:10.1371/journal.pone.0066682)

Metzger, J. et al. (2013) Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders. Gut, 62 (1). pp. 122-130. ISSN 0017-5749 (doi:10.1136/gutjnl-2012-302047)

Mischak, H. (2013) How to get proteomics to the clinic? Issues in clinical proteomics, exemplified by CE-MS. Proteomics Clinical Applications, 6 (9-10). pp. 437-442. ISSN 1862-8346 (doi:10.1002/prca.201200027)

Weissinger, E.M. et al. (2013) Proteomic peptide profiling for preemptive diagnosis of acute graft-versus-host-disease after allogeneic stem cell transplantation. Leukemia . ISSN 0887-6924 (doi:10.1038/leu.2013.210)

2012

Zurbig, P., Jerums, G., Hovind, P., MacIsaac, R.J., Mischak, H., Nielsen, S.E., Panagiotopoulos, S., Persson, F., and Rossing, P. (2012) Urinary proteomics for early diagnosis in diabetic nephropathy. Diabetes, 61 (12). pp. 3304-3313. ISSN 0012-1797 (doi:10.2337/db12-0348)

Molin, L. et al. (2012) A comparison between MALDI-MS and CE-MS data for biomarker assessment in chronic kidney diseases. Journal of Proteomics, 75 (18). pp. 5888-5897. ISSN 1874-3919 (doi:10.1016/j.jprot.2012.07.024)

von zur Muhlen, C. et al. (2012) Urine proteome analysis reflects atherosclerotic disease in an ApoE-/- mouse model and allows the discovery of new candidate biomarkers in mouse and human atherosclerosis. Molecular and Cellular Proteomics, 11 (7). M111.013847. ISSN 1535-9476 (doi:10.1074/mcp.M111.013847)

Mullen, W., Albalat, A., Gonzalez, J., Zerefos, P., Siwy, J., Franke, J., and Mischak, H. (2012) Performance of different separation methods interfaced in the same MS-reflection TOF detector: a comparison of performance between CE versus HPLC for biomarker analysis. Electrophoresis, 33 (4). pp. 567-574. ISSN 0173-0835 (doi:10.1002/elps.201100415)

Bandin, F., Siwy, J., Breuil, B., Mischak, H., Bascands, J., Decramer, S., and Schanstra, J.P. (2012) Urinary proteome analysis at 5-year followup of patients with nonoperated ureteropelvic junction obstruction suggests ongoing kidney remodeling. Journal of Urology, 187 (3). pp. 1006-1011. ISSN 0022-5347 (doi:10.1016/j.juro.2011.10.169)

Dawson, J., Walters, M., Delles, C., Mischak, H., and Mullen, W. (2012) Urinary proteomics to support diagnosis of stroke. PLoS ONE, 7 (5). e35879. ISSN 1932-6203 (doi:10.1371/journal.pone.0035879)

Kuznetsova, T., Mischak, H., Mullen, W., and Staessen, J.A. (2012) Urinary proteome analysis in hypertensive patients with left ventricular diastolic dysfunction. European Heart Journal, 33 (18). pp. 2342-2350. ISSN 0195-668X (doi:10.1093/eurheartj/ehs185)

Mullen, W., Gonzalez, J., Siwy, J., Franke, J., Sattar, N., Mullan, A., Roberts, S., Delles, C., Mischak, H., and Albalat, A. (2012) A pilot study on the effect of short-term consumption of a polyphenol rich drink on biomarkers of coronary artery disease defined by urinary proteomics. Journal of Agricultural and Food Chemistry, 59 (24). pp. 12850-12857. ISSN 0021-8561 (doi:10.1021/jf203369r)

Rouse, R., Siwy, J., Mullen, W., Mischak, H., Metzger, J., and Hanig, J. (2012) Proteomic candidate biomarkers of drug-induced nephrotoxicity in the rat. PLoS ONE, 7 (4). e34606. ISSN 1932-6203 (doi:10.1371/journal.pone.0034606)

Siwy, J. et al. (2012) Evaluation of the zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles. PLoS ONE, 7 (12). e51334. ISSN 1932-6203 (doi:10.1371/journal.pone.0051334)

2011

Albalat, A., Mischak, H., and Mullen, W. (2011) Urine proteomics in clinical applications: technologies, principal considerations and clinical implementation. Prilozi, 32 (1). pp. 13-44. ISSN 0351-3254

Lankisch, T.O. et al. (2011) Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis. Hepatology, 53 (3). pp. 875-884. ISSN 0270-9139 (doi:10.1002/hep.24103)

Lopez, L.M., Mullen, W., Zürbig, P., Harris, S.E., Gow, A.J., Starr, J.M., Porteous, D.J., Mischak, H., and Deary, I.J. (2011) A pilot study of urinary peptides as biomarkers for intelligence in old age. Intelligence, 39 (1). pp. 46-53. ISSN 0160-2896 (doi:10.1016/j.intell.2010.11.001)

Albalat, A., Mischak, H., and Mullen, W. (2011) Clinical application of urinary proteomics/peptidomics. Expert Review of Proteomics, 8 (5). pp. 615-629. ISSN 1478-9450 (doi:10.1586/epr.11.46)

Carty, D.M. et al. (2011) Urinary proteomics for prediction of preeclampsia. Hypertension, 57 (3). pp. 561-569. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.110.164285)

Kistler, A.D. et al. (2011) A distinct urinary biomarker pattern characteristic of female fabry patients that mirrors response to enzyme replacement therapy. PLoS ONE, 6 (6). e20534. ISSN 1932-6203 (doi:10.1371/journal.pone.0020534)

Metzger, J. et al. (2011) Diagnosis of subclinical and clinical acute T-cell-mediated rejection in renal transplant patients by urinary proteome analysis. Proteomics Clinical Applications, 5 (5-6). pp. 322-333. ISSN 1862-8346 (doi:10.1002/prca.201000153)

Mischak, H., Thongboonkerd, V., Schanstra, J.P., and Vlahou, A. (2011) Renal and Urinary Proteomics. Proteomics Clinical Applications, 5 (5-6). pp. 211-213. ISSN 1862-8346 (doi:10.1002/prca.201190031)

Mullen, W., Delles, C., and Mischak, H. (2011) Urinary proteomics in the assessment of chronic kidney disease. Current Opinion in Nephrology and Hypertension, 20 (6). pp. 654-661. ISSN 1062-4821 (doi:10.1097/MNH.0b013e32834b7ffa)

2010

Dakna, M., Harris, K., Kalousis, A., Carpentier, S., Kolch, W., Schanstra, J. P., Haubitz, M., Vlahou, A., Mischak, H., and Girolami, M. (2010) Addressing the Challenge of Defining Valid Proteomic Biomarkers and Classifiers. BMC Bioinformatics, 11 (1). p. 594. ISSN 1471-2105 (doi:10.1186/1471-2105-11-594)

Good, D. M. et al. (2010) Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease. Molecular and Cellular Proteomics, 9 (11). pp. 2424-2437. ISSN 1535-9476 (doi:10.1074/mcp.M110.001917)

Mischak, H. et al. (2010) Recommendations for Biomarker Identification and Qualification in Clinical Proteomics. Science Translational Medicine, 2 (46). 46ps42--. ISSN 1946-6234 (doi:10.1126/scitranslmed.3001249)

Alkhalaf, A. et al. (2010) Multicentric validation of proteomic biomarkers in urine specific for diabetic nephropathy. PLoS ONE, 5 (10). e13421. ISSN 1932-6203 (doi:10.1371/journal.pone.0013421)

Delles, C. et al. (2010) Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. Journal of Hypertension, 28 (11). pp. 2316-2322. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833d81b7)

Fadini, G.P. et al. (2010) Urinary collagen fragments are significantly altered in diabetes: a link to pathophysiology. PLoS ONE, 5 (9). e13051. ISSN 1932-6203 (doi:10.1371/journal.pone.0013051)

Metzger, J., Kirsch, T., Schiffer, E., Ulger, P., Mentes, E., Brand, K., Weissinger, E.M., Haubitz, M., Mischak, H., and Herget-Rosenthal, S. (2010) Urinary excretion of twenty peptides forms an early and accurate diagnostic pattern of acute kidney injury. Kidney International, 78 (12). pp. 1252-1262. ISSN 0085-2538 (doi:10.1038/ki.2010.322)

Mischak, H., Delles, C., Klein, J., and Schanstra, J.P. (2010) Urinary Proteomics Based on Capillary Electrophoresis-Coupled Mass Spectrometry in Kidney Disease: Discovery and Validation of Biomarkers, and Clinical Application. Advances in Chronic Kidney Disease, 17 (6). pp. 493-506. ISSN 15485595 (doi:10.1053/j.ackd.2010.09.004)

Mischak, H. et al. (2010) Comprehensive human urine standards for comparability and standardization in clinical proteome analysis. Proteomics Clinical Applications, 4 (4). pp. 464-478. ISSN 1862-8346 (doi:10.1002/prca.200900189)

Mischak, H., and Rossing, P. (2010) Proteomic biomarkers in diabetic nephropathy--reality or future promise? Nephrology, Dialysis, Transplantation, 25 (9). pp. 2843-2845. ISSN 0931-0509 (doi:10.1093/ndt/gfq363)

Mischak, H., and Schanstra, J.P. (2010) CE-MS in biomarker discovery, validation, and clinical application. Proteomics Clinical Applications, 5 (1-2). pp. 9-23. ISSN 1862-8346 (doi:10.1002/prca.201000058)

2009

Dakna, M., He, Z., Yu, W.C., Mischak, H., and Kolch, W. (2009) Technical, bioinformatical and statistical aspects of liquid chromatography–mass spectrometry (LC–MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: A critical assessment. Journal of Chromatography B, 877 (13). pp. 1250-1258. ISSN 1570-0232 (doi:10.1016/j.jchromb.2008.10.048)

Dhillon, A.S., Yip, Y.Y., Grindlay, G.J., Pakay, J.L., Dangers, M., Hillmann, M., Clark, W., Pitt, A.R., Mischak, H., and Kolch, W. (2009) The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch. Cellular Signalling, 21 (11). pp. 1645-1651. ISSN 0898-6568 (doi:10.1016/j.cellsig.2009.07.001)

Harris, K., Girolami, M., and Mischak, H. (2009) Definition of valid proteomic biomarkers: a bayesian solution. Lecture Notes in Computer Science, 5780 . pp. 137-149. ISSN 0302-9743 (doi:10.1007/978-3-642-04031-3_13)

Mischak, H., Coon, J., Novak, J., Weissinger, E., Schanstra, J., and Dominiczak, A. (2009) Capillary Electrophoresis-Mass Spectrometry As A Powerful Tool in Biomarker Discovery and Clinical Diagnosis: An Update of Recent Developments. Mass Spectrometry Reviews, 28 (5). pp. 703-724. ISSN 0277-7037 (doi:10.1002/mas.20205 )

zur Muhlen, C. et al. (2009) Evaluation of Urine Proteome Pattern Analysis for Its Potential To Reflect Coronary Artery Atherosclerosis in Symptomatic Patients. Journal of Proteome Research, 8 (1). pp. 335-345. ISSN 1535-3893 (doi:10.1021/pr800615t )

2008

Jantos-Siwy, J., Schiffer, E., Brand, K., Schumann, G., Rossing, K., Delles, C., Mischak, H., and Metzger, E. (2008) Quantitative urinary proteome analysis for biomarker evaluation in chronic kidney disease. Journal of Proteome Research, 8 (1). pp. 268-281. ISSN 1535-3893 (doi:10.1021/pr800401m)

Jiang, H. et al. (2008) Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proceedings of the National Academy of Sciences of the United States of America, 105 (32). pp. 11299-11304. ISSN 0027-8424 (doi:10.1073/pnas.0801457105)

Rossing, K., Mischak, H., Dakna, M., Zurbig, P., Novak, J., Julian, B. A., Good, D. M., Coon, J. J., Tarnow, L., and Rossing, P. (2008) Urinary Proteomics in Diabetes and CKD. Journal of the American Society of Nephrology, 19 (7). pp. 1283-1290. ISSN 1046-6673 (doi:10.1681/ASN.2007091025)

Coon, J.J. et al. (2008) CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics. Proteomics Clinical Applications, 2 (7-8). pp. 964-973. ISSN 1862-8346 (doi:10.1002/prca.200800024)

Zimmerli, L.U. et al. (2008) Urinary proteomic biomarkers on coronary artery disease. Molecular and Cellular Proteomics, 7 (2). pp. 290-298. ISSN 1535-9476 (doi:10.1074/mcp.M700394-MCP200)

2007

Mischak, H. (2007) Method and device for the qualitative and/or quantitative analysis of a protein and/or peptide pattern of a liquid sample that is derived from the human or animal body. .

This list was generated on Fri Sep 19 12:37:46 2014 BST.
Jump to: Article | Patent
Number of items: 65.

Article

Siwy, J. et al. (2014) Multicentre prospective validation of a urinary peptidome-based classifier for the diagnosis of type 2 diabetic nephropathy. Nephrology, Dialysis, Transplantation, 29 (8). pp. 1563-1570. ISSN 0931-0509 (doi:10.1093/ndt/gfu039)

Husi, H., Van Agtmael, T., Mullen, W., Bahlmann, F. H., Schanstra, J. P., Vlahou, A., Delles, C., Perco, P., and Mischak, H. (2014) Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease. Circulation: Cardiovascular Genetics, 7 (2). pp. 161-170. ISSN 1942-325X (doi:10.1161/CIRCGENETICS.113.000196)

Klein, J., Papadopoulos, T., Mischak, H., and Mullen, W. (2014) Comparison of CE-MS/MS and LC-MS/MS sequencing demonstrates significant complementarity in natural peptide identification in human urine. Electrophoresis, 35 (7). pp. 1060-1064. ISSN 0173-0835 (doi:10.1002/elps.201300327)

Mullen, W., Saigusa, D., Abe, T., Adamski, J., and Mischak, H. (2014) Proteomics and metabolomics as tools to unravel novel culprits and mechanisms of uremic toxicity: instrument or hype? Seminars in Nephrology, 34 (2). pp. 180-190. ISSN 0270-9295 (doi:10.1016/j.semnephrol.2014.02.009)

Frantzi, M. et al. (2014) Discovery and validation of urinary biomarkers for detection of renal cell carcinoma. Journal of Proteomics, 98C . pp. 44-58. ISSN 1874-3919 (doi:10.1016/j.jprot.2013.12.010)

Klein, J., Buffin-Meyer, B., Mullen, W., Carty, D. M., Delles, C., Vlahou, A., Mischak, H., Decramer, S., Bascands, J.-L., and Schanstra, J. P. (2014) Clinical proteomics in obstetrics and neonatology. Expert Review of Proteomics, 11 (1). pp. 75-89. ISSN 1478-9450 (doi:10.1586/14789450.2014.872564)

Albalat, A., Husi, H., Stalmach, A., Schanstra, J. P., and Mischak, H. (2014) Classical MALDI-MS versus CE-based ESI-MS proteomic profiling in urine for clinical applications. Bioanalysis, 6 (2). pp. 247-66. ISSN 1757-6180 (doi:10.4155/bio.13.313)

Koss, M. J. et al. (2014) Proteomics of vitreous humor of patients with exudative age-related macular degeneration. PLoS ONE, 9 (5). e96895. ISSN 1932-6203 (doi:10.1371/journal.pone.0096895)

Nkuipou-Kenfack, E. et al. (2014) Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease. PLoS ONE, 9 (5). e96955. ISSN 1932-6203 (doi:10.1371/journal.pone.0096955)

Albalat, A. et al. (2013) Improving peptide relative quantification in MALDI-TOF MS for biomarker assessment. Proteomics, 13 (20). pp. 2967-2975. ISSN 1615-9853 (doi:10.1002/pmic.201300100)

Frantzi, M. et al. (2013) IMAC fractionation in combination with LC–MS reveals H2B and NIF-1 peptides as potential bladder cancer biomarkers. Journal of Proteome Research, 12 (9). pp. 3969-3979. ISSN 1535-3893 (doi:10.1021/pr400255h)

Klein, J. et al. (2013) Fetal urinary peptides to predict postnatal outcome of renal disease in fetuses with posterior urethral valves(PUV). Science Translational Medicine, 5 (198). 198ra106. ISSN 1946-6234 (doi:10.1126/scitranslmed.3005807)

Mansor, R., Mullen, W., Albalat, A., Zerefos, P., Mischak, H., Barrett, D.C., Biggs, A., and Eckersall, P.D. (2013) A peptidomic approach to biomarker discovery for bovine mastitis. Journal of Proteomics, 85 . pp. 89-98. ISSN 1874-3919 (doi:10.1016/j.jprot.2013.04.027)

Stalmach, A., Albalat, A., Mullen, W., and Mischak, H. (2013) Recent advances in capillary electrophoresis coupled to mass spectrometry for clinical proteomic applications. Electrophoresis, 34 (11). pp. 1452-1464. ISSN 0173-0835 (doi:10.1002/elps.201200708)

Klein, J., Eales, J., Zürbig, P., Vlahou, A., Mischak, H., and Stevens, R. (2013) Proteasix: a tool for automated and large-scale prediction of proteases involved in naturally occurring peptide generation. Proteomics, 13 (7). pp. 1077-1082. ISSN 1615-9853 (doi:10.1002/pmic.201200493)

Mischak, H., Vlahou, A., and Ioannidis, J.P.A. (2013) Technical aspects and inter-laboratory variability in native peptide profiling: the CE–MS experience. Clinical Biochemistry, 46 (6). pp. 432-443. ISSN 0009-9120 (doi:10.1016/j.clinbiochem.2012.09.025)

Roscioni, S.S. et al. (2013) A urinary peptide biomarker set predicts worsening of albuminuria in type 2 diabetes mellitus. Diabetologia, 56 (2). pp. 259-267. ISSN 0012-186X (doi:10.1007/s00125-012-2755-2)

Dissard, R. et al. (2013) Long term metabolic syndrome induced by a high fat high fructose diet leads to minimal renal injury in C57BL/6 mice. PLoS ONE, 8 (10). e76703. ISSN 1932-6203 (doi:10.1371/journal.pone.0076703)

Husi, H., Sanchez-Niño, M., Delles, C., Mullen, W., Vlahou, A., Ortiz, A., and Mischak, H. (2013) A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI. BMC Systems Biology, 7 (110). ISSN 1752-0509 (doi:10.1186/1752-0509-7-110)

Kistler, A.D. et al. (2013) Urinary proteomic biomarkers for diagnosis and risk stratification of autosomal dominant polycystic kidney disease: a multicentric study. PLoS ONE, 8 (1). e53016. ISSN 1932-6203 (doi:10.1371/journal.pone.0053016)

Klein, G., Schanstra, J.P., Hoffmann, J., Mischak, H., Siwy, J., and Zimmermann, K. (2013) Proteomics as a quality control tool of pharmaceutical probiotic bacterial lysate products. PLoS ONE, 8 (6). e66682. ISSN 1932-6203 (doi:10.1371/journal.pone.0066682)

Metzger, J. et al. (2013) Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders. Gut, 62 (1). pp. 122-130. ISSN 0017-5749 (doi:10.1136/gutjnl-2012-302047)

Mischak, H. (2013) How to get proteomics to the clinic? Issues in clinical proteomics, exemplified by CE-MS. Proteomics Clinical Applications, 6 (9-10). pp. 437-442. ISSN 1862-8346 (doi:10.1002/prca.201200027)

Weissinger, E.M. et al. (2013) Proteomic peptide profiling for preemptive diagnosis of acute graft-versus-host-disease after allogeneic stem cell transplantation. Leukemia . ISSN 0887-6924 (doi:10.1038/leu.2013.210)

Zurbig, P., Jerums, G., Hovind, P., MacIsaac, R.J., Mischak, H., Nielsen, S.E., Panagiotopoulos, S., Persson, F., and Rossing, P. (2012) Urinary proteomics for early diagnosis in diabetic nephropathy. Diabetes, 61 (12). pp. 3304-3313. ISSN 0012-1797 (doi:10.2337/db12-0348)

Molin, L. et al. (2012) A comparison between MALDI-MS and CE-MS data for biomarker assessment in chronic kidney diseases. Journal of Proteomics, 75 (18). pp. 5888-5897. ISSN 1874-3919 (doi:10.1016/j.jprot.2012.07.024)

von zur Muhlen, C. et al. (2012) Urine proteome analysis reflects atherosclerotic disease in an ApoE-/- mouse model and allows the discovery of new candidate biomarkers in mouse and human atherosclerosis. Molecular and Cellular Proteomics, 11 (7). M111.013847. ISSN 1535-9476 (doi:10.1074/mcp.M111.013847)

Mullen, W., Albalat, A., Gonzalez, J., Zerefos, P., Siwy, J., Franke, J., and Mischak, H. (2012) Performance of different separation methods interfaced in the same MS-reflection TOF detector: a comparison of performance between CE versus HPLC for biomarker analysis. Electrophoresis, 33 (4). pp. 567-574. ISSN 0173-0835 (doi:10.1002/elps.201100415)

Bandin, F., Siwy, J., Breuil, B., Mischak, H., Bascands, J., Decramer, S., and Schanstra, J.P. (2012) Urinary proteome analysis at 5-year followup of patients with nonoperated ureteropelvic junction obstruction suggests ongoing kidney remodeling. Journal of Urology, 187 (3). pp. 1006-1011. ISSN 0022-5347 (doi:10.1016/j.juro.2011.10.169)

Dawson, J., Walters, M., Delles, C., Mischak, H., and Mullen, W. (2012) Urinary proteomics to support diagnosis of stroke. PLoS ONE, 7 (5). e35879. ISSN 1932-6203 (doi:10.1371/journal.pone.0035879)

Kuznetsova, T., Mischak, H., Mullen, W., and Staessen, J.A. (2012) Urinary proteome analysis in hypertensive patients with left ventricular diastolic dysfunction. European Heart Journal, 33 (18). pp. 2342-2350. ISSN 0195-668X (doi:10.1093/eurheartj/ehs185)

Mullen, W., Gonzalez, J., Siwy, J., Franke, J., Sattar, N., Mullan, A., Roberts, S., Delles, C., Mischak, H., and Albalat, A. (2012) A pilot study on the effect of short-term consumption of a polyphenol rich drink on biomarkers of coronary artery disease defined by urinary proteomics. Journal of Agricultural and Food Chemistry, 59 (24). pp. 12850-12857. ISSN 0021-8561 (doi:10.1021/jf203369r)

Rouse, R., Siwy, J., Mullen, W., Mischak, H., Metzger, J., and Hanig, J. (2012) Proteomic candidate biomarkers of drug-induced nephrotoxicity in the rat. PLoS ONE, 7 (4). e34606. ISSN 1932-6203 (doi:10.1371/journal.pone.0034606)

Siwy, J. et al. (2012) Evaluation of the zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles. PLoS ONE, 7 (12). e51334. ISSN 1932-6203 (doi:10.1371/journal.pone.0051334)

Albalat, A., Mischak, H., and Mullen, W. (2011) Urine proteomics in clinical applications: technologies, principal considerations and clinical implementation. Prilozi, 32 (1). pp. 13-44. ISSN 0351-3254

Lankisch, T.O. et al. (2011) Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis. Hepatology, 53 (3). pp. 875-884. ISSN 0270-9139 (doi:10.1002/hep.24103)

Lopez, L.M., Mullen, W., Zürbig, P., Harris, S.E., Gow, A.J., Starr, J.M., Porteous, D.J., Mischak, H., and Deary, I.J. (2011) A pilot study of urinary peptides as biomarkers for intelligence in old age. Intelligence, 39 (1). pp. 46-53. ISSN 0160-2896 (doi:10.1016/j.intell.2010.11.001)

Albalat, A., Mischak, H., and Mullen, W. (2011) Clinical application of urinary proteomics/peptidomics. Expert Review of Proteomics, 8 (5). pp. 615-629. ISSN 1478-9450 (doi:10.1586/epr.11.46)

Carty, D.M. et al. (2011) Urinary proteomics for prediction of preeclampsia. Hypertension, 57 (3). pp. 561-569. ISSN 0194-911X (doi:10.1161/HYPERTENSIONAHA.110.164285)

Kistler, A.D. et al. (2011) A distinct urinary biomarker pattern characteristic of female fabry patients that mirrors response to enzyme replacement therapy. PLoS ONE, 6 (6). e20534. ISSN 1932-6203 (doi:10.1371/journal.pone.0020534)

Metzger, J. et al. (2011) Diagnosis of subclinical and clinical acute T-cell-mediated rejection in renal transplant patients by urinary proteome analysis. Proteomics Clinical Applications, 5 (5-6). pp. 322-333. ISSN 1862-8346 (doi:10.1002/prca.201000153)

Mischak, H., Thongboonkerd, V., Schanstra, J.P., and Vlahou, A. (2011) Renal and Urinary Proteomics. Proteomics Clinical Applications, 5 (5-6). pp. 211-213. ISSN 1862-8346 (doi:10.1002/prca.201190031)

Mullen, W., Delles, C., and Mischak, H. (2011) Urinary proteomics in the assessment of chronic kidney disease. Current Opinion in Nephrology and Hypertension, 20 (6). pp. 654-661. ISSN 1062-4821 (doi:10.1097/MNH.0b013e32834b7ffa)

Dakna, M., Harris, K., Kalousis, A., Carpentier, S., Kolch, W., Schanstra, J. P., Haubitz, M., Vlahou, A., Mischak, H., and Girolami, M. (2010) Addressing the Challenge of Defining Valid Proteomic Biomarkers and Classifiers. BMC Bioinformatics, 11 (1). p. 594. ISSN 1471-2105 (doi:10.1186/1471-2105-11-594)

Good, D. M. et al. (2010) Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease. Molecular and Cellular Proteomics, 9 (11). pp. 2424-2437. ISSN 1535-9476 (doi:10.1074/mcp.M110.001917)

Mischak, H. et al. (2010) Recommendations for Biomarker Identification and Qualification in Clinical Proteomics. Science Translational Medicine, 2 (46). 46ps42--. ISSN 1946-6234 (doi:10.1126/scitranslmed.3001249)

Alkhalaf, A. et al. (2010) Multicentric validation of proteomic biomarkers in urine specific for diabetic nephropathy. PLoS ONE, 5 (10). e13421. ISSN 1932-6203 (doi:10.1371/journal.pone.0013421)

Delles, C. et al. (2010) Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. Journal of Hypertension, 28 (11). pp. 2316-2322. ISSN 0263-6352 (doi:10.1097/HJH.0b013e32833d81b7)

Fadini, G.P. et al. (2010) Urinary collagen fragments are significantly altered in diabetes: a link to pathophysiology. PLoS ONE, 5 (9). e13051. ISSN 1932-6203 (doi:10.1371/journal.pone.0013051)

Metzger, J., Kirsch, T., Schiffer, E., Ulger, P., Mentes, E., Brand, K., Weissinger, E.M., Haubitz, M., Mischak, H., and Herget-Rosenthal, S. (2010) Urinary excretion of twenty peptides forms an early and accurate diagnostic pattern of acute kidney injury. Kidney International, 78 (12). pp. 1252-1262. ISSN 0085-2538 (doi:10.1038/ki.2010.322)

Mischak, H., Delles, C., Klein, J., and Schanstra, J.P. (2010) Urinary Proteomics Based on Capillary Electrophoresis-Coupled Mass Spectrometry in Kidney Disease: Discovery and Validation of Biomarkers, and Clinical Application. Advances in Chronic Kidney Disease, 17 (6). pp. 493-506. ISSN 15485595 (doi:10.1053/j.ackd.2010.09.004)

Mischak, H. et al. (2010) Comprehensive human urine standards for comparability and standardization in clinical proteome analysis. Proteomics Clinical Applications, 4 (4). pp. 464-478. ISSN 1862-8346 (doi:10.1002/prca.200900189)

Mischak, H., and Rossing, P. (2010) Proteomic biomarkers in diabetic nephropathy--reality or future promise? Nephrology, Dialysis, Transplantation, 25 (9). pp. 2843-2845. ISSN 0931-0509 (doi:10.1093/ndt/gfq363)

Mischak, H., and Schanstra, J.P. (2010) CE-MS in biomarker discovery, validation, and clinical application. Proteomics Clinical Applications, 5 (1-2). pp. 9-23. ISSN 1862-8346 (doi:10.1002/prca.201000058)

Dakna, M., He, Z., Yu, W.C., Mischak, H., and Kolch, W. (2009) Technical, bioinformatical and statistical aspects of liquid chromatography–mass spectrometry (LC–MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: A critical assessment. Journal of Chromatography B, 877 (13). pp. 1250-1258. ISSN 1570-0232 (doi:10.1016/j.jchromb.2008.10.048)

Dhillon, A.S., Yip, Y.Y., Grindlay, G.J., Pakay, J.L., Dangers, M., Hillmann, M., Clark, W., Pitt, A.R., Mischak, H., and Kolch, W. (2009) The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch. Cellular Signalling, 21 (11). pp. 1645-1651. ISSN 0898-6568 (doi:10.1016/j.cellsig.2009.07.001)

Harris, K., Girolami, M., and Mischak, H. (2009) Definition of valid proteomic biomarkers: a bayesian solution. Lecture Notes in Computer Science, 5780 . pp. 137-149. ISSN 0302-9743 (doi:10.1007/978-3-642-04031-3_13)

Mischak, H., Coon, J., Novak, J., Weissinger, E., Schanstra, J., and Dominiczak, A. (2009) Capillary Electrophoresis-Mass Spectrometry As A Powerful Tool in Biomarker Discovery and Clinical Diagnosis: An Update of Recent Developments. Mass Spectrometry Reviews, 28 (5). pp. 703-724. ISSN 0277-7037 (doi:10.1002/mas.20205 )

zur Muhlen, C. et al. (2009) Evaluation of Urine Proteome Pattern Analysis for Its Potential To Reflect Coronary Artery Atherosclerosis in Symptomatic Patients. Journal of Proteome Research, 8 (1). pp. 335-345. ISSN 1535-3893 (doi:10.1021/pr800615t )

Jantos-Siwy, J., Schiffer, E., Brand, K., Schumann, G., Rossing, K., Delles, C., Mischak, H., and Metzger, E. (2008) Quantitative urinary proteome analysis for biomarker evaluation in chronic kidney disease. Journal of Proteome Research, 8 (1). pp. 268-281. ISSN 1535-3893 (doi:10.1021/pr800401m)

Jiang, H. et al. (2008) Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proceedings of the National Academy of Sciences of the United States of America, 105 (32). pp. 11299-11304. ISSN 0027-8424 (doi:10.1073/pnas.0801457105)

Rossing, K., Mischak, H., Dakna, M., Zurbig, P., Novak, J., Julian, B. A., Good, D. M., Coon, J. J., Tarnow, L., and Rossing, P. (2008) Urinary Proteomics in Diabetes and CKD. Journal of the American Society of Nephrology, 19 (7). pp. 1283-1290. ISSN 1046-6673 (doi:10.1681/ASN.2007091025)

Coon, J.J. et al. (2008) CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics. Proteomics Clinical Applications, 2 (7-8). pp. 964-973. ISSN 1862-8346 (doi:10.1002/prca.200800024)

Zimmerli, L.U. et al. (2008) Urinary proteomic biomarkers on coronary artery disease. Molecular and Cellular Proteomics, 7 (2). pp. 290-298. ISSN 1535-9476 (doi:10.1074/mcp.M700394-MCP200)

Patent

Mischak, H. (2007) Method and device for the qualitative and/or quantitative analysis of a protein and/or peptide pattern of a liquid sample that is derived from the human or animal body. .

This list was generated on Fri Sep 19 12:37:46 2014 BST.

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Pilot MRI Study for the Investigation of Pathophysiology in Intracerebral Haemorrhage
    Academy of Medical Sciences
    2014 - 2015
     
  • Pilot MRI Study for the Investigation of Pathophysiology in Intracerebral Haemorrhage
    Academy of Medical Sciences
    2014 - 2015
     
  • Urine proteomics as biomarker for inflammatory arthritis
    Pfizer Global Research and Development
    2013 - 2014
     
  • Cardiovascular consequences of preeclampsia in women from the Generation Scotland: Scottish Family Health Study.
    Scottish Executive Health Department
    2012 - 2014
     
  • Proteomics and Metabolomics to Help Understand and Improve Recovery in Stroke Survivors.
    The RS Macdonald Charitable Trust
    2012 - 2013
     
  • Development of an efficient, robust MS-based platform for early detection of acute kidney injury
    Medical Research Council
    2011 - 2014
     
  • The iomarkers in Stroke Programme; Detecting, Understanding, and Predicting Outcome After Stroke (ISSF Catalyst Fund)
    Wellcome Trust
    2011 - 2014
     
  • Investigating the potential of cathepsin-L as a common therapeutic target and biomarker for coronary heart disease and African trypanosomiasis (ISSF Catalyst Fund)
    Wellcome Trust
    2011 - 2014