Dr Francis Burton

  • Research Technologist (Institute of Cardiovascular and Medical Sciences)
  • Associate - Life Sciences (School of Life Sciences)

telephone: 01413306598
email: Francis.Burton@glasgow.ac.uk

Research interests

Role of Contraction-Excitation Feedback in Ventricular Arrythmogenesis*

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Atrial remodelling of calcium handling and electrophysiology in heart failure.
    British Heart Foundation
    2009 - 2013
     
  • Cellular basis for alternating T-wave morphology in isolated rabbit hearts
    British Heart Foundation
    2009 - 2012
     
  • Atrioventricular nodal function in a rabbit model of chronic heart failure
    British Heart Foundation
    2005 - 2007
     
  • Factors affecting the success of defibrillation in ischaemia
    British Heart Foundation
    2004 - 2007
     

Publications

List by: Type | Date

Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2008 | 2007 | 2005 | 2004
Number of items: 20.

2015

Ghouri, I. A., Kelly, A., Burton, F. L., Smith, G. L., and Kemi, O. J. (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi:10.1002/jbio.201300109)

2014

Campbell, A. S., Burton, F. L., Baillie, G. L., and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.

Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H., and Smith, G. L. (2014) Acidosis slows electrical conduction through the atrio-ventricular node. Frontiers in Physiology, 5(233), (doi:10.3389/fphys.2014.00233)

2013

Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Sub-epicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi:10.1161/CIRCEP.113.000334)

Kettlewell, S., Burton, F. L., Smith, G. L., and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarizations, and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi:10.1093/cvr/cvt087)

Kettlewell, S., Burton, F.L., Smith, G.L., and Workman, A.J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi:10.1093/cvr/cvt087)

Di Diego, J.M., Sicouri, S., Myles, R.C., Burton, F., Smith, G.L., and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi:10.1016/j.yjmcc.2012.10.017)

Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi:10.1161/CIRCEP.113.000334)

2012

Cheng, H., Smith, G.L., Orchard, C.H., Hancox, J.C., and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97(10), pp. 1131-1139. (doi:10.1113/expphysiol.2012.065110)

2011

Myles, R., Burton, F.L., Cobbe, S., and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi:10.1016/j.yjmcc.2010.11.019 )

2010

Burton, F.L., Malkova, D., Caslake, M.J., and Gill, J.M.R. (2010) Substrate metabolism, appetite and feeding behaviour under low and high energy turnover conditions in overweight women. British Journal of Nutrition, 104(8), pp. 1249-1259. (doi:10.1017/S0007114510002023)

Myles, R.C., Bernus, O., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi:10.1152/ajpheart.00518.2010)

Smith, G., Reynolds, M., Burton, F.L., and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. Methods in Cell Biology, 99(10), pp. 255-261. (doi:10.1016/B978-0-12-374841-6.00009-8)

2008

Burton, F.L., Malkova, D., Caslake, M.J., and Gill, J.M.R. (2008) Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese men. International Journal of Obesity, 32(3), pp. 481-489. (doi:10.1038/sj.ijo.0803754)

Lang, N.N., Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A., and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi:10.1016/j.bcp.2008.08.022 )

Myles, R.C., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi:10.1016/j.yjmcc.2008.03.024)

2007

Caldwell, J., Burton, F., Smith, G., and Cobbe, S. (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18(8), pp. 854-861. (doi:10.1111/j.1540-8167.2007.00867.x)

Walker, N., Burton, F., Kettlewell, S., Smith, G., and Cobbe, S. (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18(8), pp. 862-868. (doi:10.1111/j.1540-8167.2007.00858.x)

2005

Kohl, P., Camelliti, P., Burton, F., and Smith, G. (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38(4), pp. 45-50. (doi:10.1016/j.jelectrocard.2005.06.096)

2004

Kettlewell, S., Walker, N., Cobbe, S., Burton, F., and Smith, G. (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89(2), pp. 163-172. (doi:10.1113/expphysiol.2003.026732)

This list was generated on Tue Mar 31 06:23:45 2015 BST.
Number of items: 20.

Articles

Ghouri, I. A., Kelly, A., Burton, F. L., Smith, G. L., and Kemi, O. J. (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi:10.1002/jbio.201300109)

Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H., and Smith, G. L. (2014) Acidosis slows electrical conduction through the atrio-ventricular node. Frontiers in Physiology, 5(233), (doi:10.3389/fphys.2014.00233)

Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Sub-epicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi:10.1161/CIRCEP.113.000334)

Kettlewell, S., Burton, F. L., Smith, G. L., and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarizations, and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi:10.1093/cvr/cvt087)

Kettlewell, S., Burton, F.L., Smith, G.L., and Workman, A.J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi:10.1093/cvr/cvt087)

Di Diego, J.M., Sicouri, S., Myles, R.C., Burton, F., Smith, G.L., and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi:10.1016/j.yjmcc.2012.10.017)

Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi:10.1161/CIRCEP.113.000334)

Cheng, H., Smith, G.L., Orchard, C.H., Hancox, J.C., and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97(10), pp. 1131-1139. (doi:10.1113/expphysiol.2012.065110)

Myles, R., Burton, F.L., Cobbe, S., and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi:10.1016/j.yjmcc.2010.11.019 )

Burton, F.L., Malkova, D., Caslake, M.J., and Gill, J.M.R. (2010) Substrate metabolism, appetite and feeding behaviour under low and high energy turnover conditions in overweight women. British Journal of Nutrition, 104(8), pp. 1249-1259. (doi:10.1017/S0007114510002023)

Myles, R.C., Bernus, O., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi:10.1152/ajpheart.00518.2010)

Smith, G., Reynolds, M., Burton, F.L., and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. Methods in Cell Biology, 99(10), pp. 255-261. (doi:10.1016/B978-0-12-374841-6.00009-8)

Burton, F.L., Malkova, D., Caslake, M.J., and Gill, J.M.R. (2008) Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese men. International Journal of Obesity, 32(3), pp. 481-489. (doi:10.1038/sj.ijo.0803754)

Lang, N.N., Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A., and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi:10.1016/j.bcp.2008.08.022 )

Myles, R.C., Burton, F.L., Cobbe, S.M., and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi:10.1016/j.yjmcc.2008.03.024)

Caldwell, J., Burton, F., Smith, G., and Cobbe, S. (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18(8), pp. 854-861. (doi:10.1111/j.1540-8167.2007.00867.x)

Walker, N., Burton, F., Kettlewell, S., Smith, G., and Cobbe, S. (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18(8), pp. 862-868. (doi:10.1111/j.1540-8167.2007.00858.x)

Kohl, P., Camelliti, P., Burton, F., and Smith, G. (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38(4), pp. 45-50. (doi:10.1016/j.jelectrocard.2005.06.096)

Kettlewell, S., Walker, N., Cobbe, S., Burton, F., and Smith, G. (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89(2), pp. 163-172. (doi:10.1113/expphysiol.2003.026732)

Conference Proceedings

Campbell, A. S., Burton, F. L., Baillie, G. L., and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.

This list was generated on Tue Mar 31 06:23:45 2015 BST.