Dr Christopher Loughrey

  • Senior Lecturer (Institute of Cardiovascular and Medical Sciences)
  • Associate Academic (School of Veterinary Medicine Administration)

telephone: 01413302753
email: Christopher.Loughrey@glasgow.ac.uk

Biography

I am a Senior Lecturer based in the British Heart Foundation Glasgow Cardiovascular Research Centre (BHF GCRC) within the Institute of Cardiovascular and Medical Sciences. I graduated from the University of Glasgow in 2000 with a degree in Veterinary Medicine with commendation. I subsequently completed my PhD in 2003 having established how different FK-506 binding proteins (FKBP12.6/12.0/calstabin) alter cardiomyocyte calcium handling using novel confocal-based imaging techniques. I subsequently held a post-doctoral position at the University of Glasgow during which time I worked in collaboration with a pharmaceutical company to discover the cardiac-related action of novel therapeutic drugs (K201/JTV519). In 2005 I was appointed as Lecturer then Senior Lecturer (2010) and during my academic tenure I have been Principal Investigator on a number of project grants funded by the Medical Research Council, British Heart Foundation, Heart Research UK, Medical Research Scotland and Chief Scientist Office.

Research interests

  • The primary focus of my laboratory is to utilise an integrative approach to study the pathophysiology of myocardial infarction and heart failure and in doing so identify new drug targets with translational potential in this area of unmet clinical need.

    Key research areas in which we have considerable expertise include: cathepsins; Runt-related transcription factors (Runx1, Runx2 and Runx3); sarcoplasmic reticulum–mediated calcium handling; and ryanodine receptor function.

    To complement this approach, my research group also investigates disease states that can have a detrimental impact on the heart including African trypanosomiasis, Barth Syndrome and Rett Syndrome.

    My laboratory has practical expertise in a number of methodologies which span the level of the single cell, isolated organ, whole animal in vivo and patient including: confocal microscopy, single cell electrophysiology, fluorescence measurements/imaging, Western blotting, PCR, whole heart techniques (Langendorff perfusion and working heart preparations) and in vivo cardiovascular measurements/micro-surgery (e.g. intra-ventricular pressure-volume measurements, electrocardiography and mouse models of myocardial infarction and ischaemia–reperfusion injury).

    Further information can be found using the below link:

    Integrative Cardiac Pathophysiology

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • INVESTIGATING THE ROLE OF RUNX1 IN THE HEART POST-MYOCARDIAL INFARCTION
    Medical Research Council
    2015 - 2018
     
  • Investigation of Osteopontin as a candidate gene for left ventricular hypertrophy
    British Heart Foundation
    2014 - 2017
     
  • Angiotensin-(1-9) a novel peptide therapeutic for improving cardiac function.
    Medical Research Council
    2014 - 2015
     
  • Investigating the therapeutic potential of cathepsin-L inhibition to limit ischaemia-reperfusion injury in the heart
    Scottish Executive Health Department
    2013 - 2015
     
  • Investigating the potential of cathepsin-L as a common therapeutic target and biomarker for coronary heart disease and African trypanosomiasis (ISSF Catalyst Fund)
    Wellcome Trust
    2011 - 2014
     
  • Angiotensin 1-9 and angiotensin 1-7: assessment of their mechanisms of action as counter-regulatory renin angiotensin system peptides in cardiovascular disease
    British Heart Foundation
    2011 - 2014
     
  • Investigating the expression and function of RUNX1 in cardiac tissue during myocardial infarction
    British Heart Foundation
    2009 - 2011
     
  • The role of direct parasite-cardiomyocyte interaction in the pathogenesis of the cardiac dysfunction observed in mammals with African trypanosomiasis
    Royal College of Veterinary Surgeons
    2008 - 2009
     
  • Targeted disruption of sarcoplasmic reticulum mediated Ca2+ handling and diastolic dysfunction: A comaprison between isolated cardiomyocytes and the whole heart.
    Heart Research UK
    2007 - 2009
     
  • Annual conference of the Biophysical Society 2007
    Royal Society
    2007 - 2007
     
  • Investigating the role of intracellular calcium in the left ventricular diastolic dysfunction
    Medical Research Scotland
    2006 - 2008
     
  • Royal Society of Edinburgh international exchange programme (open) - veterinary medicine
    Royal Society of Edinburgh
    2006 - 2007
     
  • Cellular Basis of Arrhythmias:The Inter-Relationship between Ca2+ Transients and Ca2+ Waves in Cardiac Muscle
    British Heart Foundation
    2006 - 2009
     
  • Use of Micro-Conductance Technology to investigate the link between altered sarcoplasmic reticulum calcium dynamics & diastolic dysfunction.
    Tenovus-Scotland
    2005 - 2006
     
  • Use of micro-conductance technology to study cardiac pressure-volume (PV) relations in ex vivo whole rabbit hearts during acute application.
    Royal Society
    2005 - 2006
     

Teaching

I am the Module Leader for cardiovascular teaching at the School of Veterinary Medicine and have supervised a significant number of MRes and PhD students to completion since 2005.
I also teach, assess and mentor both undergraduates and postgraduates on the following degree programmes;
School of Veterinary Medical: (BVMS and BSc Veterinary Biosciences)
School of Life Sciences: (BSc Hons Level 4, MRes Biomedicine, MRes Integrative Mammalian Biology)
Institute of Cardiovascular & Medical Sciences (BHF 4 MRes programme)

Additional information

Grant Advisory Board

  • 2010 - 2010: Wellcome Trust - International Mouse Phenotyping Project Advisory Meeting

Invited International Presentations

  • 2009: Aetas Pharma Ltd - Meeting
  • 2008: USA - Gordon Research Conference - Co-chair of conference symposium
  • 2008: Trondheim, Norway - Conference at Trondheim University
  • 2007: Aetas Pharma Ltd - Meeting
  • 2003: British Cardiac Society (UK) - Conference

Prizes, Awards and Distinctions

  • 2005: 'Annual Presentations by Britain's Top Young Scientists'
  • 2003: British Cardiac Society - Judge's Prize for Oral Presentation
  • 2001: Association of Veterinary Teachers and Research Workers (AVTRW) - President's Prize for Oral Presentation
  • 1997: Silver Medal by the Royal Agricultural Society - BVMS Degree
  • 1997: Eukanuba Nutrition Prize - BVMS Degree

Professional Learned Society

  • 2005 - ongoing: European Society of Cardiology (Cardiac Cellular Electrophysiology) - Member
  • 2005 - ongoing: Veterinary Cardiology Society - Member
  • 2002 - ongoing: Biophysical Society - USA - Member
  • 2002 - ongoing: British Cardiac Society - Member
  • 2002 - ongoing: International Society for Heart Research - Member
  • 2001 - ongoing: Physiological Society - Member
  • 2000 - ongoing: British Veterinary Association - Member
  • 2000 - ongoing: Royal College of Veterinary Surgeons - Member

Publications

List by: Type | Date

Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002
Number of items: 22.

2015

McCarroll, C. S., Rossor, C. L., Morrison, L. R., Morrison, L. J., and Loughrey, C. M. (2015) A pre-clinical animal model of Trypanosoma brucei infection demonstrating cardiac dysfunction. PLoS Neglected Tropical Diseases, 9(5), e0003811. (doi:10.1371/journal.pntd.0003811) (PMID:26023927) (PMCID:PMC4449042)

2014

McKinney, C. A., Fattah, C., Loughrey, C. M., Milligan, G., and Nicklin, S. A. (2014) Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling. Clinical Science, 126, pp. 815-827. (doi:10.1042/CS20130436)

2013

Elliott, E. B. et al. (2013) T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovascular Research, 100(2), pp. 325-335. (doi:10.1093/cvr/cvt187) (PMID:23892734) (PMCID:PMC3797627)

Loughrey, C.M., and Gray, G.A. (2013) Advancing our understanding of the pathophysiology of cardiac disease using in vivo assessment of heart structure and function in rodent models. Experimental Physiology, 98(3), pp. 599-600. (doi:10.1113/expphysiol.2012.064550)

2012

Elliott, E.B., Kelly, A., Smith, G.L., and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110(12), pp. 1618-1627. (doi:10.1161/CIRCRESAHA.111.262337)

Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165(4b), pp. 1068-1083. (doi:10.1111/j.1476-5381.2011.01531.x)

2011

Currie, S., Elliott, E.B., Smith, G.L., and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131(2), pp. 204-220. (doi:10.1016/j.pharmthera.2011.02.006)

Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106(6), pp. 1009-1022. (doi:10.1007/s00395-011-0218-4)

2010

Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105(2), pp. 279-287. (doi:10.1007/s00395-009-0057-8)

2007

Volkers, M. et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41(2), pp. 135-143. (doi:10.1016/j.ceca.2006.06.001) (PMID:16919727)

Loughrey, C., Otani, N., Seidler, T., Craig, M., Matsuda, R., Kaneko, N., and Smith, G. (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76(2), pp. 236-246. (doi:10.1016/j.cardiores.2007.06.014)

Seidler, T., Loughrey, C., Zibrova, D., Kettlewell, S., Teucher, N., Kogler, H., Hasenfuss, G., and Smith, G. (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101(10), pp. 1020-1029. (doi:10.1161/CIRCRESAHA.107.154609)

2006

Colotti, G., Zamparelli, C., Verzili, D., Mella, M., Loughrey, C., Smith, G., and Chiancone, E. (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45(41), pp. 12519-12529. (doi:10.1021/bi060416a)

2005

Miller, S., Currie, S., Loughrey, C., Kettlewell, S., Seidler, T., Reynolds, D., Hasenfuss, G., and Smith, G. (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67(4), pp. 667-677. (doi:10.1016/j.cardiores.2005.04.023)

2004

Loughrey, C.M., Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E., Reynolds, D.F., Hasenfuss, G., and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556(3), pp. 919-934. (doi:10.1113/jphysiol.2003.057166)

Loughrey, C.M., Smith, G.L., and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287(3), H1149-H1159. (doi:10.1152/ajpheart.00060.2004)

Currie, S., Loughrey, C., Craig, M., and Smith, G. (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377(2), pp. 357-366. (doi:10.1042/BJ200310431)

Wokosin, D., Loughrey, C., and Smith, G. (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86(3), pp. 1726-1738. (doi:10.1016/S0006-3495(04)74241-1)

2003

Loughrey, C.M., MacEachern, K.E., Cooper, J., and Smith, G.L. (2003) Measurement of the dissociation constant of Fluo-3 for Ca2+ in isolated rabbit cardiomyocytes using Ca2+ wave characteristics. Cell Calcium, 34(1), pp. 1-9. (doi:10.1016/S0143-4160(03)00012-5)

Seidler, T. et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93(2), pp. 132-139. (doi:10.1161/01.RES.0000081596.90205.E2)

Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13(12), pp. 3535-3560. (doi:10.1142/S0218127403008843)

2002

Loughrey, C.M., MacEachern, K.E., Neary, P., and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543(3), pp. 859-870. (doi:10.1113/jphysiol.2002.021519)

This list was generated on Sun May 1 13:54:06 2016 BST.
Jump to: Articles
Number of items: 22.

Articles

McCarroll, C. S., Rossor, C. L., Morrison, L. R., Morrison, L. J., and Loughrey, C. M. (2015) A pre-clinical animal model of Trypanosoma brucei infection demonstrating cardiac dysfunction. PLoS Neglected Tropical Diseases, 9(5), e0003811. (doi:10.1371/journal.pntd.0003811) (PMID:26023927) (PMCID:PMC4449042)

McKinney, C. A., Fattah, C., Loughrey, C. M., Milligan, G., and Nicklin, S. A. (2014) Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling. Clinical Science, 126, pp. 815-827. (doi:10.1042/CS20130436)

Elliott, E. B. et al. (2013) T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovascular Research, 100(2), pp. 325-335. (doi:10.1093/cvr/cvt187) (PMID:23892734) (PMCID:PMC3797627)

Loughrey, C.M., and Gray, G.A. (2013) Advancing our understanding of the pathophysiology of cardiac disease using in vivo assessment of heart structure and function in rodent models. Experimental Physiology, 98(3), pp. 599-600. (doi:10.1113/expphysiol.2012.064550)

Elliott, E.B., Kelly, A., Smith, G.L., and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110(12), pp. 1618-1627. (doi:10.1161/CIRCRESAHA.111.262337)

Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165(4b), pp. 1068-1083. (doi:10.1111/j.1476-5381.2011.01531.x)

Currie, S., Elliott, E.B., Smith, G.L., and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131(2), pp. 204-220. (doi:10.1016/j.pharmthera.2011.02.006)

Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106(6), pp. 1009-1022. (doi:10.1007/s00395-011-0218-4)

Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105(2), pp. 279-287. (doi:10.1007/s00395-009-0057-8)

Volkers, M. et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41(2), pp. 135-143. (doi:10.1016/j.ceca.2006.06.001) (PMID:16919727)

Loughrey, C., Otani, N., Seidler, T., Craig, M., Matsuda, R., Kaneko, N., and Smith, G. (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76(2), pp. 236-246. (doi:10.1016/j.cardiores.2007.06.014)

Seidler, T., Loughrey, C., Zibrova, D., Kettlewell, S., Teucher, N., Kogler, H., Hasenfuss, G., and Smith, G. (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101(10), pp. 1020-1029. (doi:10.1161/CIRCRESAHA.107.154609)

Colotti, G., Zamparelli, C., Verzili, D., Mella, M., Loughrey, C., Smith, G., and Chiancone, E. (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45(41), pp. 12519-12529. (doi:10.1021/bi060416a)

Miller, S., Currie, S., Loughrey, C., Kettlewell, S., Seidler, T., Reynolds, D., Hasenfuss, G., and Smith, G. (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67(4), pp. 667-677. (doi:10.1016/j.cardiores.2005.04.023)

Loughrey, C.M., Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E., Reynolds, D.F., Hasenfuss, G., and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556(3), pp. 919-934. (doi:10.1113/jphysiol.2003.057166)

Loughrey, C.M., Smith, G.L., and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287(3), H1149-H1159. (doi:10.1152/ajpheart.00060.2004)

Currie, S., Loughrey, C., Craig, M., and Smith, G. (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377(2), pp. 357-366. (doi:10.1042/BJ200310431)

Wokosin, D., Loughrey, C., and Smith, G. (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86(3), pp. 1726-1738. (doi:10.1016/S0006-3495(04)74241-1)

Loughrey, C.M., MacEachern, K.E., Cooper, J., and Smith, G.L. (2003) Measurement of the dissociation constant of Fluo-3 for Ca2+ in isolated rabbit cardiomyocytes using Ca2+ wave characteristics. Cell Calcium, 34(1), pp. 1-9. (doi:10.1016/S0143-4160(03)00012-5)

Seidler, T. et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93(2), pp. 132-139. (doi:10.1161/01.RES.0000081596.90205.E2)

Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13(12), pp. 3535-3560. (doi:10.1142/S0218127403008843)

Loughrey, C.M., MacEachern, K.E., Neary, P., and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543(3), pp. 859-870. (doi:10.1113/jphysiol.2002.021519)

This list was generated on Sun May 1 13:54:06 2016 BST.