Dr Christopher Loughrey

Dr Christopher  Loughrey
  • Associate Academic (School of Veterinary Medicine)
  • Senior Lecturer (Institute of Cardiovascular and Medical Sciences)

telephone: 01413302753
email: Christopher.Loughrey@glasgow.ac.uk

Dr. Christopher M. Loughrey
University of Glasgow
Cardiovascular Research Centre
University Place G12 8TA


Dr. Christopher Loughrey is a veterinary surgeon and principal investigator within the Glasgow Cardiovascular Research Centre. His laboratory utilises a wide range of experimental techniques to investigate heart function at the level of the molecule, cell, organ and whole animal. This integrative approach provides the opportunity to study abnormal alterations of gene and protein expression/function and in turn how these changes influence whole heart function during cardiac disease. Dr. Loughrey’s laboratory has practical expertise in a number of methodologies including: confocal microscopy, single cell electrophysiology, fluorescence measurements/imaging, Western blotting, PCR, whole heart techniques (Langendorff perfusion and working heart preparations) and in vivo cardiovascular measurements/micro-surgery (e.g. intra-ventricular pressure-volume measurements, electrocardiography and a mouse model of myocardial infarction). These techniques are used in a number of projects which are on-going within the laboratory which aim to inform the development of therapeutic strategies to treat cardiac disease in animals and humans.

Research:

Member:

List all by: Type | Date

Jump to: 2014 | 2013 | 2012 | 2011 | 2010 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002
Number of items: 21.

2014

McKinney, Clare A., Fattah, Caroline, Loughrey, Christopher M., Milligan, Graeme, and Nicklin, Stuart A. (2014) Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling. Clinical Science, 126 . pp. 815-827. ISSN 0143-5221 (doi:10.1042/CS20130436)

2013

Elliott, E. B. et al. (2013) T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovascular Research, 100 (2). pp. 325-335. ISSN 0008-6363 (doi:10.1093/cvr/cvt187)

Loughrey, C.M., and Gray, G.A. (2013) Advancing our understanding of the pathophysiology of cardiac disease using in vivo assessment of heart structure and function in rodent models. Experimental Physiology, 98 (3). pp. 599-600. ISSN 0958-0670 (doi:10.1113/expphysiol.2012.064550)

2012

Elliott, E.B., Kelly, A., Smith, G.L., and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110 (12). pp. 1618-1627. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.262337)

Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165 (4b). pp. 1068-1083. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2011.01531.x)

2011

Currie, S., Elliott, E.B., Smith, G.L., and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131 (2). pp. 204-220. ISSN 0163-7258 (doi:10.1016/j.pharmthera.2011.02.006)

Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106 (6). pp. 1009-1022. ISSN 0300-8428 (doi:10.1007/s00395-011-0218-4)

2010

Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105 (2). pp. 279-287. ISSN 0300-8428 (doi:10.1007/s00395-009-0057-8)

2007

Loughrey, CM, Otani, N, Seidler, T, Craig, MA, Matsuda, R, Kaneko, N, and Smith, GL (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76 (2). pp. 236-246. ISSN 0008-6363 (doi:10.1016/j.cardiores.2007.06.014)

Seidler, T, Loughrey, CM, Zibrova, D, Kettlewell, S, Teucher, N, Kogler, H, Hasenfuss, G, and Smith, GL (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101 (10). pp. 1020-1029. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.107.154609)

Volkers, M et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41 (2). pp. 135-143. ISSN 0143-4160 (doi:10.1016/j.ceca.2006.06.001)

2006

Colotti, G, Zamparelli, C, Verzili, D, Mella, M, Loughrey, CM, Smith, GL, and Chiancone, E (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45 (41). pp. 12519-12529. ISSN 0006-2960 (doi:10.1021/bi060416a)

2005

Miller, SLW, Currie, S, Loughrey, CM, Kettlewell, S, Seidler, T, Reynolds, DF, Hasenfuss, G, and Smith, GL (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67 (4). pp. 667-677. ISSN 0008-6363 (doi:10.1016/j.cardiores.2005.04.023)

2004

Loughrey, C.M., Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E., Reynolds, D.F., Hasenfuss, G., and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556 (3). pp. 919-934. ISSN 0022-3751 (doi:10.1113/jphysiol.2003.057166)

Loughrey, C.M., Smith, G.L., and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287 (3). H1149-H1159. ISSN 0363-6135 (doi:10.1152/ajpheart.00060.2004)

Currie, S, Loughrey, CM, Craig, MA, and Smith, GL (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377 (2). pp. 357-366. ISSN 0264-6021 (doi:10.1042/BJ200310431)

Wokosin, DL, Loughrey, CM, and Smith, GL (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86 (3). pp. 1726-1738. ISSN 0006-3495 (doi:10.1016/S0006-3495(04)74241-1 )

2003

Loughrey, C.M., MacEachern, K.E., Cooper, J., and Smith, G.L. (2003) Measurement of the dissociation constant of Fluo-3 for Ca2+ in isolated rabbit cardiomyocytes using Ca2+ wave characteristics. Cell Calcium, 34 (1). pp. 1-9. ISSN 0143-4160 (doi:10.1016/S0143-4160(03)00012-5)

Seidler, T et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93 (2). pp. 132-139. ISSN 0009-7330 (doi:10.1161/01.RES.0000081596.90205.E2)

Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13 (12). pp. 3535-3560. ISSN 0218-1274 (doi:10.1142/S0218127403008843)

2002

Loughrey, C.M., MacEachern, K.E., Neary, P., and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543 (3). pp. 859-870. ISSN 0022-3751 (doi:10.1113/jphysiol.2002.021519)

This list was generated on Tue Jul 22 10:59:03 2014 BST.
Jump to: Article
Number of items: 21.

Article

McKinney, Clare A., Fattah, Caroline, Loughrey, Christopher M., Milligan, Graeme, and Nicklin, Stuart A. (2014) Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling. Clinical Science, 126 . pp. 815-827. ISSN 0143-5221 (doi:10.1042/CS20130436)

Elliott, E. B. et al. (2013) T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovascular Research, 100 (2). pp. 325-335. ISSN 0008-6363 (doi:10.1093/cvr/cvt187)

Loughrey, C.M., and Gray, G.A. (2013) Advancing our understanding of the pathophysiology of cardiac disease using in vivo assessment of heart structure and function in rodent models. Experimental Physiology, 98 (3). pp. 599-600. ISSN 0958-0670 (doi:10.1113/expphysiol.2012.064550)

Elliott, E.B., Kelly, A., Smith, G.L., and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110 (12). pp. 1618-1627. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.111.262337)

Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165 (4b). pp. 1068-1083. ISSN 0007-1188 (doi:10.1111/j.1476-5381.2011.01531.x)

Currie, S., Elliott, E.B., Smith, G.L., and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131 (2). pp. 204-220. ISSN 0163-7258 (doi:10.1016/j.pharmthera.2011.02.006)

Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L., and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106 (6). pp. 1009-1022. ISSN 0300-8428 (doi:10.1007/s00395-011-0218-4)

Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105 (2). pp. 279-287. ISSN 0300-8428 (doi:10.1007/s00395-009-0057-8)

Loughrey, CM, Otani, N, Seidler, T, Craig, MA, Matsuda, R, Kaneko, N, and Smith, GL (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76 (2). pp. 236-246. ISSN 0008-6363 (doi:10.1016/j.cardiores.2007.06.014)

Seidler, T, Loughrey, CM, Zibrova, D, Kettlewell, S, Teucher, N, Kogler, H, Hasenfuss, G, and Smith, GL (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101 (10). pp. 1020-1029. ISSN 0009-7330 (doi:10.1161/CIRCRESAHA.107.154609)

Volkers, M et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41 (2). pp. 135-143. ISSN 0143-4160 (doi:10.1016/j.ceca.2006.06.001)

Colotti, G, Zamparelli, C, Verzili, D, Mella, M, Loughrey, CM, Smith, GL, and Chiancone, E (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45 (41). pp. 12519-12529. ISSN 0006-2960 (doi:10.1021/bi060416a)

Miller, SLW, Currie, S, Loughrey, CM, Kettlewell, S, Seidler, T, Reynolds, DF, Hasenfuss, G, and Smith, GL (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67 (4). pp. 667-677. ISSN 0008-6363 (doi:10.1016/j.cardiores.2005.04.023)

Loughrey, C.M., Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E., Reynolds, D.F., Hasenfuss, G., and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556 (3). pp. 919-934. ISSN 0022-3751 (doi:10.1113/jphysiol.2003.057166)

Loughrey, C.M., Smith, G.L., and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287 (3). H1149-H1159. ISSN 0363-6135 (doi:10.1152/ajpheart.00060.2004)

Currie, S, Loughrey, CM, Craig, MA, and Smith, GL (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377 (2). pp. 357-366. ISSN 0264-6021 (doi:10.1042/BJ200310431)

Wokosin, DL, Loughrey, CM, and Smith, GL (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86 (3). pp. 1726-1738. ISSN 0006-3495 (doi:10.1016/S0006-3495(04)74241-1 )

Loughrey, C.M., MacEachern, K.E., Cooper, J., and Smith, G.L. (2003) Measurement of the dissociation constant of Fluo-3 for Ca2+ in isolated rabbit cardiomyocytes using Ca2+ wave characteristics. Cell Calcium, 34 (1). pp. 1-9. ISSN 0143-4160 (doi:10.1016/S0143-4160(03)00012-5)

Seidler, T et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93 (2). pp. 132-139. ISSN 0009-7330 (doi:10.1161/01.RES.0000081596.90205.E2)

Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13 (12). pp. 3535-3560. ISSN 0218-1274 (doi:10.1142/S0218127403008843)

Loughrey, C.M., MacEachern, K.E., Neary, P., and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543 (3). pp. 859-870. ISSN 0022-3751 (doi:10.1113/jphysiol.2002.021519)

This list was generated on Tue Jul 22 10:59:03 2014 BST.

Grant Advisory Board

  • 2010 - 2010: Wellcome Trust - International Mouse Phenotyping Project Advisory Meeting

Invited International Presentations

  • 2009: Aetas Pharma Ltd - Meeting
  • 2008: USA - Gordon Research Conference - Co-chair of conference symposium
  • 2008: Trondheim, Norway - Conference at Trondheim University
  • 2007: Aetas Pharma Ltd - Meeting
  • 2003: British Cardiac Society (UK) - Conference

Prizes, Awards and Distinctions

  • 2005: 'Annual Presentations by Britain's Top Young Scientists'
  • 2003: British Cardiac Society - Judge's Prize for Oral Presentation
  • 2001: Association of Veterinary Teachers and Research Workers (AVTRW) - President's Prize for Oral Presentation
  • 1997: Silver Medal by the Royal Agricultural Society - BVMS Degree
  • 1997: Eukanuba Nutrition Prize - BVMS Degree

Professional Learned Society

  • 2005 - ongoing: European Society of Cardiology (Cardiac Cellular Electrophysiology) - Member
  • 2005 - ongoing: Veterinary Cardiology Society - Member
  • 2002 - ongoing: Biophysical Society - USA - Member
  • 2002 - ongoing: British Cardiac Society - Member
  • 2002 - ongoing: International Society for Heart Research - Member
  • 2001 - ongoing: Physiological Society - Member
  • 2000 - ongoing: British Veterinary Association - Member
  • 2000 - ongoing: Royal College of Veterinary Surgeons - Member