Vascular Pathophysiology and Therapy (VPT)

The Vascular Pathophysiology and Therapy research theme brings together eleven internationally recognized basic, translational and clinical research group leaders within the Institute of Cardiovascular and Medical Sciences. 

Our research programmes adopt a wide range of approaches and techniques; from genomics for high throughput SNP genotyping and gene expression profiling, proteomics and molecular/cell biological analysis of vascular cell signalling, through to assessment of vascular physiology and function in animal models and patients.  

Our goal is to develop an increased understanding of vascular function and the genetic, molecular and cellular level in the laboratory, to identify and validate new targets and translate this knowledge into the clinic by developing innovative therapeutics for treatment of cardiovascular diseases.  To achieve this, we are forging collaborative links with colleagues with complimentary expertise in other Research Institutes both within the University and beyond. 

Our research programmes arebased in state-of-the-art clinical research facilities and dedicated laboratories, ranging from physiology and electrophysiology laboratories to well equipped molecular and cellular biology laboratories with facilities for sophisticated human and experimental genetic analysis.  Capabilities also include high end proteomics and genomics platforms for high throughput SNP genotyping as well as profiling of gene and microRNA expression patterns in disease states, and facilities for the development of novel vascular gene transfer therapies for cardiovascular diseases.

 Our Research