Professor Peter Adams

  • Professor (Epigenetics)

Research interests

Adams figure

The Adams lab investigates the impact of chromatin structure and epigenetics on cell proliferation, aging and cancer. In particular, we hypothesize that age-associated changes in chromatin structure, function and regulation contribute to the dramatic age-associated increase in incidence of cancer. While age is the biggest single risk factor for most cancers, the reason for this is current poorly understood. 

Figure 1

Peter Adams fig 1

Figure 2            DNA methylation gains and losses in senescent cells overlap with hyper and hypomethylation in cancer. Paradoxically, this suggests that the epigenome of senescent cells might be primed for progression to cancer. In turn, this suggests that senescence might be an imperfect tumor suppressor mechanism, and accumulation of senescent cells with age might predispose to cancer. The reason(s) why cancer increases with age in humans is poorly understood, at present. See Cruickshanks et al, 2013 for details.

Lab members

Peter D. Adams, PhD - p.adams@beatson.gla.ac.uk
Peter Adams obtained his BA in biochemistry at the University of Oxford, England and his PhD at Imperial Cancer Research Fund (now CR-UK). He did post-doctoral work with Dr. William G. Kaelin, Jr. at Dana-Farber Cancer Institute. He set up his own lab at Fox Chase Cancer Center in 1999 and moved to the CR-UK Beatson Institute and Glasgow University in October of 2008. Peter Adams is co-Editor-in-Chief of the journal Aging Cell.

Jeff Pawlikowski, BSc - j.pawlikowski@beatson.gla.ac.uk
Jeff Pawlikowski obtained his BSc and MSc from Drexel University, Philadelphia. Jeff iobtained his PhD at Glasgow University , UK

Indrani Manoharan, MSc. - i.manoharan@beatson.gla.ac.uk
Indrani Manoharan obtained her MSc from University of Leicester, UK

Rachael Hewitt, BSc. - RachaelnHewitt@gmail.com
Rachael Hewitt obtained her BSc from the University of Glasgow, UK

Desy Piscitello, BSc. - d.piscitello@beatson.gla.ac.uk
Desy is currently a PhD student at the University of Glasgow, UK

Taranjit Singh Rai, PhD. - tsrai11@gmail.com
Taranjit Singh Rai obtained his PhD from the Post Graduate Institute of Medical Education & Research, Chandigarh, India

Nikolay Pchelintsev, PhD. - n.a.pchelintsev@googlemail.com
Nikolay Pchelintsev obtained his PhD from the University of Leeds, UK

John van Tuyn, PhD. - jvantuyn@hotmail.com
John van Tuyn obtained his PhD from Leiden University Medical Center, Leiden, the Netherlands

Tony McBryan, PhD. - tony@mcbryan.co.uk
Tony McBryan obtained his PhD from the University of Glasgow

Dina Dikovskaya, PhD. - Dina.Dikovskaya@glasgow.ac.uk
Dina Dikovskaya obtained her PhD from Institute of Genetics (Institut für Genetik), Forschungszentrum Karlsruhe, Germany

Claire Brock, BSc. - Claire.Brock@glasgow.ac.uk
Claire Brock obtained her BSc from the University of Glasgow.

Annie-Louise Latif, MBCHB, MRCP. - Anne-Louise.Latif@glasgow.ac.uk
Annie Latif obtained her MBCHB from University of Glasgow in 2002.

Douglas MacKenzie, BSc (Hons) MBChB (Hons) MRCS (Ed). Douglas.Mackenzie@glasgow.ac.uk

John Cole, BSc. - johnjcole@hotmail.co.uk
John Cole obtained his BSc and MRes in bioinformatics from the University of Glasgow.

Farah Jaber-Hijazi, PhD. - farah.h.j@gmail.com
Farah Jaber-Hijazi obtained her MSc at the Universities of Manchester, Salford and Keele and her PhD from the University of Nottingham.

Research Collaborations

The lab has extensive collaborations with other labs throughout the world. In particular, we collaborate closely with the labs of Dr. Shelley Berger (University of Pennsylvania, Philadelphia), Ronen Marmorstein (Wistar Institute, Philadelphia) and Brad Johnson (University of Pennsylvania, Philadelphia). These collaborations are funded by an NIH program project grant on the “Epigenetics of aging and age-associated diseases“ (http://agingepigenetics.wordpress.com/). 

Rachael Hewitt is funded by a BBSRC/CASE studentship in collaboration with Dr. David Gunn at Unilever (Colworth, England) and Dr. Andre Maier at the University of Leiden (Netherlands).

We have recently been awarded funding by the BBSRC to investigate the role of autophagy and DNA damage signalling in senescence; this is a collaborative award with Dr. Joao Passos, University of Newcastle.

Link to research page in the Beatson Institute

Publications

List by: Type | Date

Jump to: 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008
Number of items: 31.

2014

Soni, S., Pchelintsev, N., Adams, P. D., and Bieker, J. J. (2014) Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for -globin gene expression. Proceedings of the National Academy of Sciences of the United States of America, 111 (37). pp. 13337-13342. ISSN 0027-8424 (doi:10.1073/pnas.1405422111)

Lund, K., Cole, J., VanderKraats, N. D., McBryan, T., Pchelintsev, N. A., Clark, W., Copland, M., Edwards, J. R., and Adams, P. (2014) DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML. Genome Biology, 15 (7). p. 406. ISSN 1465-6906 (doi:10.1186/s13059-014-0406-2)

Adams, P., Antebi, A., Cuervo, A.M., Kennedy, B., and Sedivy, J. (2014) Aging cell: open access to all. Aging Cell, 13 (1). p. 1. ISSN 1474-9718 (doi:10.1111/acel.12187)

Lund, K., Adams, P.D., and Copland, M. (2014) EZH2 in normal and malignant hematopoiesis. Leukemia, 28 (1). pp. 44-49. ISSN 0887-6924 (doi:10.1038/leu.2013.288)

2013

Pawlikowski, J.S., McBryan, T., van Tuyn, J., Drotar, M.E., Hewitt, R.N., Maier, A.B., King, A., Blyth, K., Wu, H., and Adams, P.D. (2013) Wnt signaling potentiates nevogenesis. Proceedings of the National Academy of Sciences of the United States of America, 110 (40). pp. 16009-16014. ISSN 0027-8424 (doi:10.1073/pnas.1303491110)

Pawlikowski, J.S., Adams, P.D., and Nelson, D.M. (2013) Senescence at a glance. Journal of Cell Science, 126 (18). pp. 4061-4067. ISSN 0021-9533 (doi:10.1242/jcs.109728)

Shah, P.P. et al. (2013) Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes and Development, 27 (16). pp. 1787-1799. ISSN 0890-9369 (doi:10.1101/gad.223834.113)

Shah, P. et al. (2013) Lamin B1 depletion in senescent cells triggers large scale changes in gene expression and in the chromatin landscape genes and development. Genes and Development, 27 (16). pp. 1787-1799. ISSN 0890-9369 (doi:10.1101/gad.223834.113 )

Ivanov, A. et al. (2013) Lysosome-mediated processing of chromatin in senescence. Journal of Cell Biology, 202 (1). pp. 129-143. ISSN 0021-9525 (doi:10.1083/jcb.201212110)

Pchelintsev, N.A., McBryan, T., Rai, T.S., van Tuyn, J., Ray-Gallet, D., Almouzni, G., and Adams, P.D. (2013) Placing the HIRA histone chaperone complex in the chromatin landscape. Cell Reports, 3 (4). pp. 1012-1019. ISSN 2211-1247 (doi:10.1016/j.celrep.2013.03.026)

Sawicka, M., Pawlikowski, J., Wilson, S., Ferdinando, D., Wu, H., Adams, P.D., Gunn, D.A., and Parish, W. (2013) The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding. PLoS ONE, 8 (1). e53313. ISSN 1932-6203 (doi:10.1371/journal.pone.0053313)

Adams, P., Antebi, A., Cuervo, A.M., Kennedy, B., and Sedivy, J. (2013) Editorial. Aging Cell, 12 (1). p. 1. ISSN 1474-9718 (doi:10.1111/acel.12037)

Cruickshanks, H.A. et al. (2013) Senescent cells harbour features of the cancer epigenome. Nature Cell Biology, 15 (12). pp. 1495-1506. ISSN 1465-7392 (doi:10.1038/ncb2879)

Howard, L., Mackenzie, R. M., Pchelintsev, N. A., McBryan, T., McClure, J. D., McBride, M. W., Kane, N. M., Adams, P. D., Milligan, G., and Baker, A. H. (2013) Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment. Stem Cell Research and Therapy, 4 (2). Art. 36. ISSN 1757-6512 (doi:10.1186/scrt192)

Rosenfeldt, M.T. et al. (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature, 504 (7479). pp. 296-300. ISSN 0028-0836 (doi:10.1038/nature12865)

2012

Dekker, P. et al. (2012) Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts. Mechanisms of Ageing and Development, 133 (7). pp. 498-507. ISSN 0047-6374 (doi:10.1016/j.mad.2012.06.002)

Rai, T.S., and Adams, P.D. (2012) Lessons from senescence: chromatin maintenance in non-proliferating cells. Biochimica et Biophysica Acta (BBA): Gene Regulatory Mechanisms, 1819 (3-4). pp. 322-331. ISSN 1874-9399 (doi:10.1016/j.bbagrm.2011.07.014)

Tang, Y., Puri, A., Ricketts, M.D., Rai, T.S., Hoffmann, J., Hoi, E., Adams, P.D., Schultz, D.C., and Marmorstein, R. (2012) Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex. Biochemistry, 51 (12). pp. 2366-2377. ISSN 0006-2960 (doi:10.1021/bi300050b)

van Tuyn, J., and Adams, P.D. (2012) Signalling the end of the line. Nature Cell Biology, 14 (4). pp. 339-341. ISSN 1465-7392 (doi:10.1038/ncb2476)

2011

Ray-Gallet, D. et al. (2011) Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity. Molecular Cell, 44 (6). pp. 928-941. ISSN 1097-2765 (doi:10.1016/j.molcel.2011.12.006)

Kennedy, A.l. et al. (2011) Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis. Molecular Cell, 42 (1). pp. 36-49. ISSN 1097-2765 (doi:10.1016/j.molcel.2011.02.020)

Ivanov, A., and Adams, P.D. (2011) A damage limitation exercise. Nature Cell Biology, 13 (3). p. 193. ISSN 1465-7392 (doi:10.1038/ncb0311-193)

Cruickshanks, H.A.., and Adams, P.D. (2011) Chromatin: a molecular interface between cancer and aging. Current Opinion in Genetics and Development, 21 (1). pp. 100-106. ISSN 0959-437X (doi:10.1016/j.gde.2010.10.007 )

Rai, T., Puri, A., McBryan, T., Hoffman, J., Tang, Y., Pchelintsev, N.A., van Tuyn, J., Marmorstein, R., Schultz, D.C., and Adams, P.D. (2011) Human CABIN1 Is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Molecular and Cellular Biology, 31 (19). pp. 4107-4118. ISSN 0270-7306 (doi:10.1128/MCB.05546-11)

2010

Kennedy, A.L., McBryan, A., Enders, G.H., Johnson, F.B., Zhang, R., and Adams, P.D., (2010) Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. Cell Division, 5 (16). ISSN 1747-1028 (doi:10.1186/1747-1028-5-16)

Kreiling, J.A. et al. (2010) Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell, 10 (2). pp. 292-304. ISSN 1474-9718 (doi:10.1111/j.1474-9726.2010.00666.x)

Poleshko, A., Einarson, M.B., Shalginskikh, N., Zhang, R., Adams, P.D., Skalka , A.M., and Katz, R.A. (2010) Identification of a functional network of human epigenetic silencing factors. Journal of Biological Chemistry, 285 . 422 -433. ISSN 0021-9258 (doi:10.1074/jbc.M109.064667 )

2009

Adams, P. (2009) Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence. Molecular Cell, 36 (1). pp. 2-14. ISSN 1097-2765 (doi:10.1016/j.molcel.2009.09.021 )

Ambagala, A.P., Bosma, T., Ali, M.A., Poustovoitov, M., Chen, J.J., Gershon, M.D., Adams, P.D., and Cohen, J.I. (2009) Varicella-Zoster Virus immediate-early 63 protein interacts with human anti-silencing function 1 protein and alters its ability to bind histones H3.1 and H3.3. J. Journal of Virology, 83 (1). pp. 200-209. ISSN 0022-538X (doi:10.1128/JVI.00645-08)

Banumathy, G., Somaiah, N., Zhang, R., Tang, Y., Hoffmann, J., Andrake, M., Ceulemans, H., Schultz, D., Marmorstein, R., and Adams, P. (2009) Human UBN1 Is an Ortholog of Yeast Hpc2p and Has an Essential Role in the HIRA/ASF1a Chromatin-Remodeling Pathway in Senescent Cells. Molecular and Cellular Biology, 29 (3). pp. 758-770. ISSN 0270-7306 (doi:10.1128/MCB.01047-08)

2008

Poleshko, A., Palagin, I., Zhang, R., Boimel, P., Castagna, C., Adams, P.D., Skalka, A.M., and Katz, R.A. (2008) Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response. Journal of Virology, 82 . pp. 2313-2323. ISSN 0022-538X (doi:10.1128/JVI.01882-07)

This list was generated on Thu Oct 23 05:05:19 2014 BST.
Jump to: Article
Number of items: 31.

Article

Soni, S., Pchelintsev, N., Adams, P. D., and Bieker, J. J. (2014) Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for -globin gene expression. Proceedings of the National Academy of Sciences of the United States of America, 111 (37). pp. 13337-13342. ISSN 0027-8424 (doi:10.1073/pnas.1405422111)

Lund, K., Cole, J., VanderKraats, N. D., McBryan, T., Pchelintsev, N. A., Clark, W., Copland, M., Edwards, J. R., and Adams, P. (2014) DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML. Genome Biology, 15 (7). p. 406. ISSN 1465-6906 (doi:10.1186/s13059-014-0406-2)

Adams, P., Antebi, A., Cuervo, A.M., Kennedy, B., and Sedivy, J. (2014) Aging cell: open access to all. Aging Cell, 13 (1). p. 1. ISSN 1474-9718 (doi:10.1111/acel.12187)

Lund, K., Adams, P.D., and Copland, M. (2014) EZH2 in normal and malignant hematopoiesis. Leukemia, 28 (1). pp. 44-49. ISSN 0887-6924 (doi:10.1038/leu.2013.288)

Pawlikowski, J.S., McBryan, T., van Tuyn, J., Drotar, M.E., Hewitt, R.N., Maier, A.B., King, A., Blyth, K., Wu, H., and Adams, P.D. (2013) Wnt signaling potentiates nevogenesis. Proceedings of the National Academy of Sciences of the United States of America, 110 (40). pp. 16009-16014. ISSN 0027-8424 (doi:10.1073/pnas.1303491110)

Pawlikowski, J.S., Adams, P.D., and Nelson, D.M. (2013) Senescence at a glance. Journal of Cell Science, 126 (18). pp. 4061-4067. ISSN 0021-9533 (doi:10.1242/jcs.109728)

Shah, P.P. et al. (2013) Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes and Development, 27 (16). pp. 1787-1799. ISSN 0890-9369 (doi:10.1101/gad.223834.113)

Shah, P. et al. (2013) Lamin B1 depletion in senescent cells triggers large scale changes in gene expression and in the chromatin landscape genes and development. Genes and Development, 27 (16). pp. 1787-1799. ISSN 0890-9369 (doi:10.1101/gad.223834.113 )

Ivanov, A. et al. (2013) Lysosome-mediated processing of chromatin in senescence. Journal of Cell Biology, 202 (1). pp. 129-143. ISSN 0021-9525 (doi:10.1083/jcb.201212110)

Pchelintsev, N.A., McBryan, T., Rai, T.S., van Tuyn, J., Ray-Gallet, D., Almouzni, G., and Adams, P.D. (2013) Placing the HIRA histone chaperone complex in the chromatin landscape. Cell Reports, 3 (4). pp. 1012-1019. ISSN 2211-1247 (doi:10.1016/j.celrep.2013.03.026)

Sawicka, M., Pawlikowski, J., Wilson, S., Ferdinando, D., Wu, H., Adams, P.D., Gunn, D.A., and Parish, W. (2013) The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding. PLoS ONE, 8 (1). e53313. ISSN 1932-6203 (doi:10.1371/journal.pone.0053313)

Adams, P., Antebi, A., Cuervo, A.M., Kennedy, B., and Sedivy, J. (2013) Editorial. Aging Cell, 12 (1). p. 1. ISSN 1474-9718 (doi:10.1111/acel.12037)

Cruickshanks, H.A. et al. (2013) Senescent cells harbour features of the cancer epigenome. Nature Cell Biology, 15 (12). pp. 1495-1506. ISSN 1465-7392 (doi:10.1038/ncb2879)

Howard, L., Mackenzie, R. M., Pchelintsev, N. A., McBryan, T., McClure, J. D., McBride, M. W., Kane, N. M., Adams, P. D., Milligan, G., and Baker, A. H. (2013) Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment. Stem Cell Research and Therapy, 4 (2). Art. 36. ISSN 1757-6512 (doi:10.1186/scrt192)

Rosenfeldt, M.T. et al. (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature, 504 (7479). pp. 296-300. ISSN 0028-0836 (doi:10.1038/nature12865)

Dekker, P. et al. (2012) Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts. Mechanisms of Ageing and Development, 133 (7). pp. 498-507. ISSN 0047-6374 (doi:10.1016/j.mad.2012.06.002)

Rai, T.S., and Adams, P.D. (2012) Lessons from senescence: chromatin maintenance in non-proliferating cells. Biochimica et Biophysica Acta (BBA): Gene Regulatory Mechanisms, 1819 (3-4). pp. 322-331. ISSN 1874-9399 (doi:10.1016/j.bbagrm.2011.07.014)

Tang, Y., Puri, A., Ricketts, M.D., Rai, T.S., Hoffmann, J., Hoi, E., Adams, P.D., Schultz, D.C., and Marmorstein, R. (2012) Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex. Biochemistry, 51 (12). pp. 2366-2377. ISSN 0006-2960 (doi:10.1021/bi300050b)

van Tuyn, J., and Adams, P.D. (2012) Signalling the end of the line. Nature Cell Biology, 14 (4). pp. 339-341. ISSN 1465-7392 (doi:10.1038/ncb2476)

Ray-Gallet, D. et al. (2011) Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity. Molecular Cell, 44 (6). pp. 928-941. ISSN 1097-2765 (doi:10.1016/j.molcel.2011.12.006)

Kennedy, A.l. et al. (2011) Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis. Molecular Cell, 42 (1). pp. 36-49. ISSN 1097-2765 (doi:10.1016/j.molcel.2011.02.020)

Ivanov, A., and Adams, P.D. (2011) A damage limitation exercise. Nature Cell Biology, 13 (3). p. 193. ISSN 1465-7392 (doi:10.1038/ncb0311-193)

Cruickshanks, H.A.., and Adams, P.D. (2011) Chromatin: a molecular interface between cancer and aging. Current Opinion in Genetics and Development, 21 (1). pp. 100-106. ISSN 0959-437X (doi:10.1016/j.gde.2010.10.007 )

Rai, T., Puri, A., McBryan, T., Hoffman, J., Tang, Y., Pchelintsev, N.A., van Tuyn, J., Marmorstein, R., Schultz, D.C., and Adams, P.D. (2011) Human CABIN1 Is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Molecular and Cellular Biology, 31 (19). pp. 4107-4118. ISSN 0270-7306 (doi:10.1128/MCB.05546-11)

Kennedy, A.L., McBryan, A., Enders, G.H., Johnson, F.B., Zhang, R., and Adams, P.D., (2010) Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. Cell Division, 5 (16). ISSN 1747-1028 (doi:10.1186/1747-1028-5-16)

Kreiling, J.A. et al. (2010) Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell, 10 (2). pp. 292-304. ISSN 1474-9718 (doi:10.1111/j.1474-9726.2010.00666.x)

Poleshko, A., Einarson, M.B., Shalginskikh, N., Zhang, R., Adams, P.D., Skalka , A.M., and Katz, R.A. (2010) Identification of a functional network of human epigenetic silencing factors. Journal of Biological Chemistry, 285 . 422 -433. ISSN 0021-9258 (doi:10.1074/jbc.M109.064667 )

Adams, P. (2009) Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence. Molecular Cell, 36 (1). pp. 2-14. ISSN 1097-2765 (doi:10.1016/j.molcel.2009.09.021 )

Ambagala, A.P., Bosma, T., Ali, M.A., Poustovoitov, M., Chen, J.J., Gershon, M.D., Adams, P.D., and Cohen, J.I. (2009) Varicella-Zoster Virus immediate-early 63 protein interacts with human anti-silencing function 1 protein and alters its ability to bind histones H3.1 and H3.3. J. Journal of Virology, 83 (1). pp. 200-209. ISSN 0022-538X (doi:10.1128/JVI.00645-08)

Banumathy, G., Somaiah, N., Zhang, R., Tang, Y., Hoffmann, J., Andrake, M., Ceulemans, H., Schultz, D., Marmorstein, R., and Adams, P. (2009) Human UBN1 Is an Ortholog of Yeast Hpc2p and Has an Essential Role in the HIRA/ASF1a Chromatin-Remodeling Pathway in Senescent Cells. Molecular and Cellular Biology, 29 (3). pp. 758-770. ISSN 0270-7306 (doi:10.1128/MCB.01047-08)

Poleshko, A., Palagin, I., Zhang, R., Boimel, P., Castagna, C., Adams, P.D., Skalka, A.M., and Katz, R.A. (2008) Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response. Journal of Virology, 82 . pp. 2313-2323. ISSN 0022-538X (doi:10.1128/JVI.01882-07)

This list was generated on Thu Oct 23 05:05:19 2014 BST.