The Adams lab studies chromatin-mediated control of cell proliferation and function, most notably cell senescence. Cell senescence is an irreversible proliferation arrest instigated by a variety of molecular triggers including acquisition of activated oncogenes, and shortened telomeres caused by excess rounds of cell division. In addition, senescent cells secrete a cocktail of inflammatory cytokines, chemokines and matrix proteases (the "inflammatory secretome") that is capable of influencing behavior of neighboring cells, including immune cells. Compelling evidence now indicates that cell senescence is a potent tumor suppression mechanism, notably in cells harboring activated oncogenes. Senescence-associated proliferation arrest and the inflammatory secretome act in concert to achieve tumor suppression: proliferation arrest directly curtails tumor growth and the inflammatory secretome calls on innate immune cells to eliminate the offending damaged cells. Because of senescence, most primary human cells have a finite proliferative lifespan, and evidence has been presented that senescence contributes to tissue ageing in vivo, in part by limiting the proper self-renewal of stem cells and tissues. In sum, cell senescence has both beneficial (healing) and detrimental (hurting) effects for a multicellular organism.
Peter D. Adams, PhD - firstname.lastname@example.org
Peter Adams obtained his BA in biochemistry at the University of Oxford, England and his PhD at Imperial Cancer Research Fund (now CR-UK). He did post-doctoral work with Dr. William G. Kaelin, Jr. at Dana-Farber Cancer Institute. He set up his own lab at Fox Chase Cancer Center in 1999 and moved to the CR-UK Beatson Institute and Glasgow University in October of 2008.
Jeff Pawlikowski, BSc - email@example.com
Jeff Pawlikowski obtained his BSc and MSc from Drexel University, Philadelphia. Jeff is currently a PhD student at Glasgow University , UK
David M. Nelson, BSc. - firstname.lastname@example.org
David Nelson obtained his BSc from Messiah College, Pennsylvania. David is currently a PhD student at Glasgow University, UK
Indrani Manoharan, MSc. - email@example.com
Indrani Manoharan obtained her MSc from University of Leicester, UK
Rachael Hewitt, BSc. - RachaelnHewitt@gmail.com
Rachael Hewitt obtained her BSc from the University of Glasgow, UK
Taranjit Singh Rai, PhD. - firstname.lastname@example.org
Taranjit Singh Rai obtained his PhD from the Post Graduate Institute of Medical Education & Research, Chandigarh, India
Nikolay Pchelintsev, PhD. - email@example.com
Nikolay Pchelintsev obtained his PhD from the University of Leeds, UK
John van Tuyn, PhD. - firstname.lastname@example.org
John van Tuyn obtained his PhD from Leiden University Medical Center, Leiden, the Netherlands
Andrejs Ivanov, PhD. - email@example.com
Andrejs Ivanov obtained his PhD from the University of Manchester
Hazel Cruickshanks, PhD. - firstname.lastname@example.org
Hazel Cruickshanks obtained her PhD from the University of Edinburgh
Tony McBryan, PhD. - email@example.com
Tony McBryan obtained his PhD from the University of Glasgow
Mark Drotar, MSc. - Mark.Drotar@glasgow.ac.uk
Mark Drotar obtained a Master Science from Colorado State University
Kirstin Lund, MCChB Euro, MRCP. - Kirstin.Lund@glasgow.ac.uk
Kirstin Lund was awarded an MCChB Euro from Manchester University and is a Member of the Royal College of Physicians (MRCP), London
Dina Dikovskaya, PhD. - Dina.Dikovskaya@glasgow.ac.uk
Dina Dikovskaya obtained her PhD from Institute of Genetics (Institut für Genetik), Forschungszentrum Karlsruhe, Germany
The lab has extensive collaborations with other labs throughout the world.
In particular, we collaborate closely with the labs of Dr. Shelley Berger (University of Pennsylvania, Philadelphia), Ronen Marmorstein (Wistar Institute, Philadelphia) and Brad Johnson (University of Pennsylvania, Philadelphia). These collaborations are funded by an NIH program project grant on the "Epigenetics of aging and age-associated diseases" (http://agingepigenetics.wordpress.com/)
We are also recipients of joint funding from the BBSRC and United States NIA to fund collaborative work with Professor John Sedivy at Brown University, on "The Wnt - chromatin axis in aging".
Rachael Hewitt is funded by a BBSRC/CASE studentship in collaboration with Dr. David Gunn at Unilever (Colworth, England) and Dr. Andrea Maier at the University of Leiden (Netherlands).
We are always open to new collaborations.