Professor Paul Shiels

  • Professor (Epigenetics)
  • Associate Academic (Institute of Health and Wellbeing)

telephone: 01413307280
email: Paul.Shiels@glasgow.ac.uk

Research interests

Professor Shiels career has spanned both industry and academia and has involved 25 years developing a fundamental understanding of biological ageing. He was among the first internationally to clone and analyse telomeres and developed one of the first rat genomic mapping panels to enable the positional cloning of the AGU gene in a bio-ageing mutant (Craig NJ, Duran Alonso MB, Hawker KL, Shiels P, et al (2001) Nat Neuroscience.4:1061-1062). Subsequently, at PPL Therapeutics, Roslin, he helped develop the internationally recognised Xenotransplantation programme and undertook the analysis of senescence in cloned animals (including Dolly the sheep - Shiels PG et al Nature 399:316-317).

 

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • A
    A
    2016 - 2016
     

Publications

List by: Type | Date

Jump to: 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2001 | 2000 | 1999
Number of items: 95.

2014

Kooman, J. P., Kotanko, P., Schols, A. M. W. J., Shiels, P. G., and Stenvinkel, P. (2014) Chronic kidney disease and premature ageing. Nature Reviews Nephrology, 10(12), pp. 732-742. (doi:10.1038/nrneph.2014.185)

Gardner, M. et al. (2014) Gender and telomere length: systematic review and meta-analysis. Experimental Gerontology, 51, pp. 15-27. (doi:10.1016/j.exger.2013.12.004)

Mayes, M. D. et al. (2014) Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. American Journal of Human Genetics, 94(1), pp. 47-61. (doi:10.1016/j.ajhg.2013.12.002) (PMID:24387989) (PMCID:PMC3882906)

McGlynn, L.M. et al. (2014) SIRT2: Tumour suppressor or tumour promoter in operable breast cancer? European Journal of Cancer, 50(2), pp. 290-301. (doi:10.1016/j.ejca.2013.10.005) (PMID:24183459)

López-Isac, E. et al. (2014) A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility. Arthritis Research and Therapy, 16, R6. (doi:10.1186/ar4432) (PMID:24401602) (PMCID:PMC3978735)

2013

Cavanagh, J. et al. (2013) Socioeconomic status and the cerebellar grey matter volume. Data from a well-characterised population sample. Cerebellum, 12(6), pp. 882-891. (doi:10.1007/s12311-013-0497-4)

Carmona, F. D. et al. (2013) New insight on the Xq28 association with systemic sclerosis. Annals of the Rheumatic Diseases, 72(12), pp. 2032-2038. (doi:10.1136/annrheumdis-2012-202742) (PMID:23444193) (PMCID:PMC3818491)

Robinson, M. W., McGuinness, D., Swann, R., Barclay, S., Mills, P. R., Patel, A. H., McLauchlan, J., and Shiels, P. G. (2013) Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease. Aging Cell, 12(6), pp. 1141-1143. (doi:10.1111/acel.12125) (PMID:23931242)

Krishnadas, R. et al. (2013) Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health study. Psychosomatic Medicine, 75(7), pp. 616-623. (doi:10.1097/PSY.0b013e3182a151a7)

Pathai, S., Shiels, P.G., Weiss, H.A., Gilbert, C.E., Peto, T., Bekker, L., Wood, R., Wong, T.Y., and Lawn, S.D. (2013) Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing. Mechanisms of Ageing and Development, 134(9), pp. 400-406. (doi:10.1016/j.mad.2013.08.002)

Pathai, S., Gilbert, C.E., Lawn, S.D., Weiss, H.A., Peto, T., Cook, C., Wong, T.Y., and Shiels, P.G. (2013) Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers. Mechanisms of Ageing and Development, 134(7-8), pp. 338-345. (doi:10.1016/j.mad.2013.05.002)

Pathai, S., Shiels, P.G., Lawn, S.D., Cook, C., and Gilbert, C. (2013) The eye as a model of ageing in translational research – molecular, epigenetic and clinical aspects. Ageing Research Reviews, 12(2), pp. 490-508. (doi:10.1016/j.arr.2012.11.002)

McGlynn, L.M., Eller, K., MacDonald, A.I., MacIntyre, A., Russell, D., Koppelstaetter, C., Davies, R., and Shiels, P.G. (2013) Pathfinder cells provide a novel therapeutic intervention for acute kidney injury. Rejuvenation Research, 16(1), pp. 11-20. (doi:10.1089/rej.2012.1350)

Gingell-Littlejohn, M., Kohli, H., Aitken, E., Shiels, P.G., Geddes, C., Kingsmore, D., and Clancy, M.J. (2013) Below-target postoperative arterial blood pressure but not central venous pressure is associated with delayed graft function. Transplantation Proceedings, 45(1), pp. 46-50. (doi:10.1016/j.transproceed.2012.03.058)

Bossini-Castillo, L. et al. (2013) Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study. Annals of the Rheumatic Diseases, 72(4), pp. 602-607. (doi:10.1136/annrheumdis-2012-201888)

Carmona, F.D. et al. (2013) The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis. PLoS ONE, 8(1), e54419. (doi:10.1371/journal.pone.0054419)

Diaz-Gallo, L.M. et al. (2013) Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility. Annals of the Rheumatic Diseases, 72(7), pp. 1233-1238. (doi:10.1136/annrheumdis-2012-202357)

Gardner, M.P. et al. (2013) Telomere length and physical performance at older ages: an individual participant meta-analysis. PLoS ONE, 8(7), e69526. (doi:10.1371/journal.pone.0069526)

Gingell-Littlejohn, M., McGuinness, D., McGlynn, L.M., Kingsmore, D., Stevenson, K.S., Koppelstaetter, C., Clancy, M.J., and Shiels, P. (2013) Pre-transplant CDKN2A expression in kidney biopsies predicts renal function and is a future component of donor scoring criteria. PLoS ONE, 8(7), e68133. (doi:10.1371/journal.pone.0068133)

Krishnadas, R. et al. (2013) Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: results from the psychological, social and biological determinants of ill health (pSoBid) study. Neuroimage: Clinical, 2(2013), pp. 646-657. (doi:10.1016/j.nicl.2013.04.012)

Millar, K. et al. (2013) Personality, socio-economic status and inflammation: cross-sectional, population-based study. PLoS ONE, 8(3), e58256. (doi:10.1371/journal.pone.0058256)

Pathai, S. et al. (2013) Accelerated biological aging in HIV-infected individuals in South Africa: a case–control study. AIDS, 27(15), pp. 2375-2384. (doi:10.1097/QAD.0b013e328363bf7f)

Pathai, S., Lawn, S.D., Shiels, P.G., Weiss, H.A., Cook, C., Wood, R., and Gilbert, C.E. (2013) Corneal endothelial cells provide evidence of accelerated cellular senescence associated with HIV infection: a case-control study. PLoS ONE, 8(2), e57422. (doi:10.1371/journal.pone.0057422)

Robertson, T., Batty, G.S., Der, G., Fenton, C., Shiels, P.G., and Benzeval, M. (2013) Is socioeconomic status associated with biological aging as measured by telomere length? Epidemiologic Reviews, 35(1), pp. 98-111. (doi:10.1093/epirev/mxs001)

Roxburgh, C.S., Richards, C.H., MacDonald, A.I., Powell, A.G., McGlynn, L.M., McMillan, D.C., Horgan, P.G., Edwards, J., and Shiels, P.G. (2013) The in situ local immune response, tumour senescence and proliferation in colorectal cancer. British Journal of Cancer, 109(8), pp. 2207-2216. (doi:10.1038/bjc.2013.556)

2012

Sebastián, C. et al. (2012) The histone deacetylase SIRT6 is a novel tumor suppressor that controls cancer metabolism. Cell, 151(6), pp. 1185-1199. (doi:10.1016/j.cell.2012.10.047)

McLean, J. et al. (2012) Early life socioeconomic status, chronic physiological stress and hippocampal N-acetyl aspartate concentrations. Behavioural Brain Research, 235(2), pp. 225-230. (doi:10.1016/j.bbr.2012.08.013)

Packard, C. et al. (2012) Interaction of personality traits with social deprivation in determining mental wellbeing and health behaviours. Journal of Public Health, 34(4), pp. 615-624. (doi:10.1093/pubmed/fds030)

Miller, A. M. et al. (2012) Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes? PLoS ONE, 7(10), e47830. (doi:10.1371/journal.pone.0047830)

Knox, S. et al. (2012) 25-hydroxyvitamin D is lower in deprived groups, but is not associated with carotid intima media thickness or plaques: results from pSoBid. Atherosclerosis, 223(2), pp. 437-441. (doi:10.1016/j.atherosclerosis.2012.05.001)

Robertson, T., Batty, G.D., Der, G., Green, M.J., McGlynn, L.M., McIntyre, A., Shiels, P.G., and Benzeval, M. (2012) Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 study. PLoS ONE, 7(7), e41805. (doi:10.1371/journal.pone.0041805)

Bossini-Castillo, L. et al. (2012) A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Human Molecular Genetics, 21(4), pp. 926-933. (doi:10.1093/hmg/ddr522)

McGuinness, D. et al. (2012) Socio-economic status is associated with epigenetic differences in the pSoBid cohort. International Journal of Epidemiology, 41(1), pp. 151-160. (doi:10.1093/ije/dyr215)

Alfred, T. et al. (2012) A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon Programme. PLoS ONE, 7(1), e29883. (doi:10.1371/journal.pone.0029883)

Bossini-Castillo, L. et al. (2012) KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor. Arthritis Research and Therapy, 14(6), R273. (doi:10.1186/ar4124)

Der, G., Batty, G.D., Benzeval, M., Deary, I.J., Green, M.J., McGlynn, L., McIntyre, A., Robertson, T., and Shiels, P.G. (2012) Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland? PLoS ONE, 7(9), e45166. (doi:10.1371/journal.pone.0045166)

Gardani, M., McMillan, T., Shiels, P., McGlynn, L., and Stewart, E. (2012) An investigation of biological ageing processes following head injury. In: International Brain Injury Association's Ninth World Congress on Brain Injury, Edinburgh, UK, 21-25 Mar 2012, pp. 309-799. (doi:10.3109/02699052.2012.660091)

Shiels, P.G. (2012) CDKN2A might be better than telomere length in determining individual health status. British Medical Journal, 344, e1415. (doi:10.1136/bmj.e1415)

2011

Carmona, F.D. et al. (2011) Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis. Annals of the Rheumatic Diseases, 70(11), pp. 2050-2052. (doi:10.1136/ard.2010.148874)

Maxwell, F., McGlynn, L.M., Muir, H.C., Talwar, D., Benzeval, M., Robertson, T., Roxburgh, C.S., McMillan, D., Horgan, P.G., and Shiels, P. (2011) Telomere attrition and decreased Fetuin A levels indicate accelerated biological ageing and are implicated in the pathogenesis of colorectal cancer. Clinical Cancer Research, 17(17), pp. 5573-5581. (doi:10.1158/1078-0432.CCR-10-3271)

Bossini-Castillo, L. et al. (2011) A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort. Annals of the Rheumatic Diseases, 70(4), pp. 638-641. (doi:10.1136/ard.2010.141838)

Birnie, K. et al. (2011) Childhood socioeconomic position and objectively measured physical capability levels in adulthood: a systematic review and meta-analysis. PLoS ONE, 6(1), e15564. (doi:10.1371/journal.pone.0015564)

Bossini-Castillo, L. et al. (2011) Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population. Rheumatology, 50(11), pp. 1976-1981. (doi:10.1093/rheumatology/ker259)

McCarthy, M.I. et al. (2011) Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. PLoS Genetics, 7(7), e1002178. (doi:10.1371/journal.pgen.1002178)

McGuinness, D., McGuinness, D.H., McCaul, J., and Shiels, P.G. (2011) Sirtuins, bioageing, and cancer. Journal of Aging Research, 2011, p. 235754. (doi:10.4061/2011/235754)

Packard, C.J. et al. (2011) Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study. BMC Public Health, 11, p. 42. (doi:10.1186/1471-2458-11-42)

Shiels, P.G. et al. (2011) Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort. PLoS ONE, 6(7), e22521. (doi:10.1371/journal.pone.0022521)

Stevenson, K. et al. (2011) Pancreatic derived pathfinder cells enable regeneration of critically damaged adult pancreatic tissue and completely reverse streptozotocin induced diabetes. Rejuvenation Research, 14(2), pp. 163-171. (doi:10.1089/rej.2010.1099)

2010

Cooper, R., Kuh, D., Hardy, R., and Mortality Review Group on behalf of the FALCon and HALCyon study teams, (2010) Objectively measured physical capability levels and mortality: systematic review and meta-analysis. British Medical Journal, 341, c4467. (doi:10.1136/bmj.c4467)

Elsberger, B., Fullerton, R., Zino, S., Jordan, F., Mitchell, T.J., Brunton, V.G., Mallon, E.A., Shiels, P.G., and Edwards, J. (2010) Breast cancer patients' clinical outcome measures are associated with Src kinase family member expression. British Journal of Cancer, 103(6), pp. 899-909. (doi:10.1038/sj.bjc.6605829)

Cooper, R., Kuh, D., Cooper, C., Gale, C. R., Lawlor, D. A., Matthews, F., Hardy, R., and FALCon and HALCyon , S. T. (2010) Objective measures of physical capability and subsequent health: a systematic review. Age and Ageing, 40(1), pp. 14-23. (doi:10.1093/ageing/afq117)

Radstake, T.R.D.J. et al. (2010) Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nature Genetics, 42(5), pp. 426-429. (doi:10.1038/ng.565)

Shiels, P.G. (2010) Improving precision in investigating aging: why telomeres can cause problems. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 65A(8), pp. 789-791. (doi:10.1093/gerona/glq095)

Simpson, R.J., Cosgrove, C., Chee, M.M., McFarlin, B.K., Bartlett, D.B., Spielmann, G., O'Connor, D.P., Pircher, H., and Shiels, P.G. (2010) Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans. Exercise Immunology Review, 16, pp. 40-55.

2009

Stevenson, K.S., McGlynn, L.M., Hodge, M., McLinden, H., George, W.D., Davies, R.W., and Shiels, P.G. (2009) Isolation, characterization, and differentiation of Thy1.1-sorted pancreatic adult progenitor cell populations. Stem Cells and Development, 18(10), pp. 1389-1398. (doi:10.1089/scd.2008.0301)

Stevenson, K.S., McGlynn, L.M., and Shiels, P.G. (2009) Stem cells: outstanding potential and outstanding questions. Scottish Medical Journal, 54(4), pp. 35-37. (doi:10.1258/rsmsmj.54.4.35 )

Batty, G.D., Wang, Y., Brouilette, S.W., Shiels, P.G., Packard, C.J., Moore, J., Samani, N.J., and Ford, I. (2009) Socioeconomic status and telomere length: the West of Scotland Coronary Prevention Study. Journal of Epidemiology and Community Health , 63(10), pp. 839-841. (doi:10.1136/jech.2009.088427)

McGlynn, L.M., Stevenson, K., Lamb, K., Zino, S., Brown, M., Prina, A., Kingsmore, D., and Shiels, P.G. (2009) Cellular senescence in pre-transplant renal biopsies predicts postoperative organ function. Aging Cell, 8(1), pp. 45-51. (doi:10.1111/j.1474-9726.2008.00447.x)

Deans, K.A. et al. (2009) Differences in atherosclerosis according to area level socioeconomic deprivation: cross sectional, population based study. British Medical Journal, 339, b4170. (doi:10.1136/bmj.b4170)

El Fangour, S., Marini, M., Good, J., McQuaker, S.J., Shiels, P.G., and Hartley, R.C. (2009) Nitrones for understanding and ameliorating the oxidative stress associated with aging. Age, 31(4), pp. 269-276. (doi:10.1007/s11357-009-9098-z) (PMID:19479343) (PMCID:PMC2813050)

Lamb, K.J., and Shiels, P.G. (2009) Telomeres, ageing and oxidation. In: Foyer, C.H., Faragher, R. and Thornally, P.J. (eds.) Redox Metabolism and Longevity Relationships in Animals and Plants. Series: SEB experimental biology series (62). Taylor and Francis: New York, USA, pp. 117-137. ISBN 9780415419543

2008

Maclntyre, A., Brouilette, S.W., Lamb, K., Radhakrishnan, K., McGlynn, L.M., Chee, M.M., Parkinson, E.K., Freeman, D., Madhok, R., and Shiels, P.G. (2008) Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion. Annals of the Rheumatic Diseases, 67(12), pp. 1780-1782. (doi:10.1136/ard.2007.086652)

Starr, J.M., Shiels, P.G., Harris, S.E., Pattie, A., Pearce, M.S., Relton, C.L., and Deary, I.J. (2008) Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. Mechanisms of Ageing and Development, 129(12), pp. 745-751. (doi:10.1016/j.mad.2008.09.020)

Carrero, J.J., Shiels, P.G., and Stenvinkel, P. (2008) Telomere biology alterations as a mortality risk factor in CKD. American Journal of Kidney Diseases, 51(6), pp. 1076-1077. (doi:10.1053/j.ajkd.2008.02.367)

Stevenson, K.S., Radhakrishnan, K., Patterson, C.S., McMillan, L.C., Skeldon, K.D., Buist, L., Padgett, M., and Shiels, P.G. (2008) Breath ethane peaks during a single haemodialysis session and is associated with time on dialysis. Journal of Breath Research, 2(2), 026004. (doi:10.1088/1752-7155/2/2/026004)

Carrero, J.J. et al. (2008) Telomere attrition is associated with inflammation, low fetuin-A levels and high mortality in prevalent haemodialysis patients. Journal of Internal Medicine, 263(3), pp. 302-312. (doi:10.1111/j.1365-2796.2007.01890.x)

Chee, M.M., MacIntyre, A., Brouilette, S.W., Madhok, R., and Shiels, P.G. (2008) Association of increased telomere lengths in scleroderma with no age-related telomere erosion. Rheumatology, 47(Sup. 2), ii23. (doi:10.1093/rheumatology/kem511)

Velupillai, Y.N. et al. (2008) Psychological, social and biological determinants of ill health (pSoBid): study protocol of a population-based study. BMC Public Health, 8(126), (doi:10.1186/1471-2458-8-126)

2007

Patterson, C.S., McMillan, L.C., Stevenson, K., Radhakrishnan, K., Shiels, P.G., Padgett, M., and Skeldon, K.D. (2007) Dynamic study of oxidative stress in renal dialysis patients based on breath ethane measured by optical spectroscopy. Journal of Breath Research, 1(2), 026005. (doi:10.1088/1752-7155/1/2/026005)

Starr, J.M., McGurn, B., Harris, S.E., Whalley, L.J., Deary, I.J., and Shiels, P.G. (2007) Association between telomere length and heart disease in a narrow age cohort of older people. Experimental Gerontology, 42(6), pp. 571-573. (doi:10.1016/j.exger.2006.12.002)

Al Kushi, A., Russell, D., Shiels, P.G., Davies, R.W., and Payne, A.P. (2007) Lewy-body protein immunoreactivity in the midbrain of a PKC-gamma mutant rat. Journal of Anatomy, 210(5), pp. 606-607.

Carrero, J.J. et al. (2007) Telomere shortening, a new mortality risk factor in dialysis patients. Associations with inflammatory markers and fetuin-a levels. Blood Purification, 25(4), p. 338.

Russell, D., Shiels, P.G., and Payne, A.P. (2007) Effects of the agu mutation on ageing and senescence in the brain and kidney in vivo. Journal of Anatomy, 210(5), pp. 624-625.

Stevenson, K., and Shiels, P.G. (2007) Cellular therapy for diabetes. Dumfries and Galloway Medical Journal, 5, pp. 7-13.

2006

Chen, D., Weber, M., Shiels, P.G., Dong, R., Webster, Z., Mcvey, J.H., Kemball-Cook, G., Tuddenham, E.G.D., Lechler, R.I., and Dorling, A. (2006) Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins. Journal of Thrombosis and Haemostasis, 4(10), pp. 2191-2198. (doi:10.1111/j.1538-7836.2006.02100.x)

Harris, S.E., Deary, I.J., Maclntyre, A., Lamb, K.J., Radhakrishnan, K., Starr, J.M., Whalley, L.J., and Shiels, P.G. (2006) The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people. Neuroscience Letters, 406(3), pp. 260-264. (doi:10.1016/j.neulet.2006.07.055)

Ashraf, N., Zino, S., MacIntyre, A., Kingsmore, D., Payne, A.P., George, W.D., and Shiels, P.G. (2006) Altered sirtuin expression is associated with node-positive breast cancer. British Journal of Cancer, 95, pp. 1056-1061. (doi:10.1038/sj.bjc.6603384)

Lamb, K., Stevenson, K.S., Zino, S., MacIntyre, A., Kingsmore, D., Jardine, A.G., Marson, L., Forsyth, J.L.R., and Shiels, P.G. (2006) Telomere binding protein expression correlates with cold ischemic time and late graft dysfunction in human renal allografts, as a result of accelerated organ senescence. Nephrology, Dialysis, Transplantation, 21, pp. 259-260.

Nolan, C.E., Melin, J., Marson, L., Forsyth, J.L.R., Jardine, A.G., and Shiels, P.G. (2006) Insulin protects from accelerated senescence secondary to ischaemia/reperfusion injury in STZ diabetic rats. Nephrology, Dialysis, Transplantation, 21, p. 4.

Sklavounou, E., Hay, A., Ashraf, N., Lamb, K., Brown, E., Mac Intyre, A., George, W.D., Hartley, R.C., and Shiels, P.G. (2006) The use of telomere biology to identify and develop superior nitrone based anti-oxidants. Biochemical and Biophysical Research Communications, 347, pp. 420-427. (doi:10.1016/j.bbrc.2006.06.087)

2005

Al-Fayez, M., Russell, D., Wayne Davies, R., Shiels, P.G., and Baker, P. (2005) Deficits in the mid-brain raphe nuclei and striatum of the AS/AGU rat, a protein kinase C-gamma mutant. European Journal of Neuroscience, 22(11), pp. 2792-2798. (doi:10.1111/j.1460-9568.2005.04502.x)

Shiels, P.G., Mac Intyre, A., Chen, D., Dorling, A., Deardon, D., and Subrimaniam, M. (2005) IV administration of adult stem cells mitigates STZ induced diabetes in a xenotransplant model. American Journal of Transplantation, 5(S11), p. 369. (doi:10.1111/j.1600-6135.2005.authind.x)

Shiels, P.G. (2005) Adult stem cells mitigate the effects of STZ diabetes. Horizons in Medicine, 17, pp. 241-249.

2004

Chen, D.X., Giannopoulos, K., Shiels, P.G., Webster, Z., Mcvey, J.H., Kemball-Cook, G., Tuddenham, E., Moore, M., Lechler, R., and Dorling, A. (2004) Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium. Blood, 104(5), pp. 1344-1349. (doi:10.1182/blood-2003-12-4365)

Hillyard, D.Z., Cameron, A.J.M., McDonald, K.J., Thomson, J., MacIntyre, A., Shiels, P.G., Panarelli, M., and Jardine, A.G. (2004) Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease. Atherosclerosis, 175(2), pp. 305-313. (doi:10.1016/j.atherosclerosis.2004.03.018)

Nolan, C.E., Wright, S.M., and Shiels, P.G. (2004) Senescence and transplantation. Transplant Topics, 15, pp. 6-9.

Shiels, P.G., and Davies, R.W. (2004) Ageing and death in neurones. In: Davies, R.W. and Morris, B.J. (eds.) Molecular Biology of the Neuron. Series: Molecular and cellular neurobiology series. Oxford University Press: Oxford, UK, pp. 435-464. ISBN 9780198509981

2003

Joosten, S.A., van Ham, V., Nolan, C.E., Borrias, M.C., Jardine, A.G., Shiels, P.G., van Kooten, C., and Paul, L.C. (2003) Telomere shortening and cellular senescence in a model of chronic renal allograft rejection. American Journal of Pathology, 162(4), pp. 1305-1312. (doi:10.1016/S0002-9440(10)63926-0)

Shiels, P.G., and Jardine, A.G. (2003) Dolly, no longer the exception: Telomeres and implications for transplantation. Cloning Stem Cells, 5(2), pp. 157-160.

2001

Ayres, D., Colman, A., Dai, Y., Shiels, P.G., and Moore, M. (2001) Cloning pigs deficient in alpha 1,3 galactosyltransferase. Graft, 4, pp. 80-82.

Craig, N.J. et al. (2001) A candidate gene for human neurodegenerative disorders: a rat PKCγ mutation causes a Parkinsonian syndrome. Nature Neuroscience, 4, pp. 1061-1062. (doi:10.1038/nn740 )

2000

Shiels, P.G. (2000) Innovations conceptuelles et technologieques a l'aube du trosième millenaire. In: Dimanches biologiques de Lariboisière, Paris, 16-18 Nov 2000, pp. 73-80.

1999

Shiels, P.G., Kind, A.J., Campbell, K.H.S., Wilmut, I., Waddington, D., Colman, A., and Schnieke, A.E. (1999) Analysis of telomere length in Dolly, a sheep derived by nuclear transfer. Cloning, 1(2), pp. 119-125. (doi:10.1089/15204559950020003)

Shiels, P. (1999) Somatic cell nuclear transfer as a tool for investigating ageing processes in mammals. Gene Therapy and Molecular Biology, 4, pp. 11-22.

Shiels, P.G., Kind, A.J., Campbell, K.H.S., Waddington, D., Wilmut, I., Colman, A., and Schnieke, A.E. (1999) Analysis of telomere lengths in cloned sheep. Nature, 399(6734), pp. 316-317. (doi:10.1038/20580)

This list was generated on Tue Jun 30 04:58:44 2015 BST.
Number of items: 95.

Articles

Kooman, J. P., Kotanko, P., Schols, A. M. W. J., Shiels, P. G., and Stenvinkel, P. (2014) Chronic kidney disease and premature ageing. Nature Reviews Nephrology, 10(12), pp. 732-742. (doi:10.1038/nrneph.2014.185)

Gardner, M. et al. (2014) Gender and telomere length: systematic review and meta-analysis. Experimental Gerontology, 51, pp. 15-27. (doi:10.1016/j.exger.2013.12.004)

Mayes, M. D. et al. (2014) Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. American Journal of Human Genetics, 94(1), pp. 47-61. (doi:10.1016/j.ajhg.2013.12.002) (PMID:24387989) (PMCID:PMC3882906)

McGlynn, L.M. et al. (2014) SIRT2: Tumour suppressor or tumour promoter in operable breast cancer? European Journal of Cancer, 50(2), pp. 290-301. (doi:10.1016/j.ejca.2013.10.005) (PMID:24183459)

López-Isac, E. et al. (2014) A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility. Arthritis Research and Therapy, 16, R6. (doi:10.1186/ar4432) (PMID:24401602) (PMCID:PMC3978735)

Cavanagh, J. et al. (2013) Socioeconomic status and the cerebellar grey matter volume. Data from a well-characterised population sample. Cerebellum, 12(6), pp. 882-891. (doi:10.1007/s12311-013-0497-4)

Carmona, F. D. et al. (2013) New insight on the Xq28 association with systemic sclerosis. Annals of the Rheumatic Diseases, 72(12), pp. 2032-2038. (doi:10.1136/annrheumdis-2012-202742) (PMID:23444193) (PMCID:PMC3818491)

Robinson, M. W., McGuinness, D., Swann, R., Barclay, S., Mills, P. R., Patel, A. H., McLauchlan, J., and Shiels, P. G. (2013) Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease. Aging Cell, 12(6), pp. 1141-1143. (doi:10.1111/acel.12125) (PMID:23931242)

Krishnadas, R. et al. (2013) Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health study. Psychosomatic Medicine, 75(7), pp. 616-623. (doi:10.1097/PSY.0b013e3182a151a7)

Pathai, S., Shiels, P.G., Weiss, H.A., Gilbert, C.E., Peto, T., Bekker, L., Wood, R., Wong, T.Y., and Lawn, S.D. (2013) Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing. Mechanisms of Ageing and Development, 134(9), pp. 400-406. (doi:10.1016/j.mad.2013.08.002)

Pathai, S., Gilbert, C.E., Lawn, S.D., Weiss, H.A., Peto, T., Cook, C., Wong, T.Y., and Shiels, P.G. (2013) Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers. Mechanisms of Ageing and Development, 134(7-8), pp. 338-345. (doi:10.1016/j.mad.2013.05.002)

Pathai, S., Shiels, P.G., Lawn, S.D., Cook, C., and Gilbert, C. (2013) The eye as a model of ageing in translational research – molecular, epigenetic and clinical aspects. Ageing Research Reviews, 12(2), pp. 490-508. (doi:10.1016/j.arr.2012.11.002)

McGlynn, L.M., Eller, K., MacDonald, A.I., MacIntyre, A., Russell, D., Koppelstaetter, C., Davies, R., and Shiels, P.G. (2013) Pathfinder cells provide a novel therapeutic intervention for acute kidney injury. Rejuvenation Research, 16(1), pp. 11-20. (doi:10.1089/rej.2012.1350)

Gingell-Littlejohn, M., Kohli, H., Aitken, E., Shiels, P.G., Geddes, C., Kingsmore, D., and Clancy, M.J. (2013) Below-target postoperative arterial blood pressure but not central venous pressure is associated with delayed graft function. Transplantation Proceedings, 45(1), pp. 46-50. (doi:10.1016/j.transproceed.2012.03.058)

Bossini-Castillo, L. et al. (2013) Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study. Annals of the Rheumatic Diseases, 72(4), pp. 602-607. (doi:10.1136/annrheumdis-2012-201888)

Carmona, F.D. et al. (2013) The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis. PLoS ONE, 8(1), e54419. (doi:10.1371/journal.pone.0054419)

Diaz-Gallo, L.M. et al. (2013) Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility. Annals of the Rheumatic Diseases, 72(7), pp. 1233-1238. (doi:10.1136/annrheumdis-2012-202357)

Gardner, M.P. et al. (2013) Telomere length and physical performance at older ages: an individual participant meta-analysis. PLoS ONE, 8(7), e69526. (doi:10.1371/journal.pone.0069526)

Gingell-Littlejohn, M., McGuinness, D., McGlynn, L.M., Kingsmore, D., Stevenson, K.S., Koppelstaetter, C., Clancy, M.J., and Shiels, P. (2013) Pre-transplant CDKN2A expression in kidney biopsies predicts renal function and is a future component of donor scoring criteria. PLoS ONE, 8(7), e68133. (doi:10.1371/journal.pone.0068133)

Krishnadas, R. et al. (2013) Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: results from the psychological, social and biological determinants of ill health (pSoBid) study. Neuroimage: Clinical, 2(2013), pp. 646-657. (doi:10.1016/j.nicl.2013.04.012)

Millar, K. et al. (2013) Personality, socio-economic status and inflammation: cross-sectional, population-based study. PLoS ONE, 8(3), e58256. (doi:10.1371/journal.pone.0058256)

Pathai, S. et al. (2013) Accelerated biological aging in HIV-infected individuals in South Africa: a case–control study. AIDS, 27(15), pp. 2375-2384. (doi:10.1097/QAD.0b013e328363bf7f)

Pathai, S., Lawn, S.D., Shiels, P.G., Weiss, H.A., Cook, C., Wood, R., and Gilbert, C.E. (2013) Corneal endothelial cells provide evidence of accelerated cellular senescence associated with HIV infection: a case-control study. PLoS ONE, 8(2), e57422. (doi:10.1371/journal.pone.0057422)

Robertson, T., Batty, G.S., Der, G., Fenton, C., Shiels, P.G., and Benzeval, M. (2013) Is socioeconomic status associated with biological aging as measured by telomere length? Epidemiologic Reviews, 35(1), pp. 98-111. (doi:10.1093/epirev/mxs001)

Roxburgh, C.S., Richards, C.H., MacDonald, A.I., Powell, A.G., McGlynn, L.M., McMillan, D.C., Horgan, P.G., Edwards, J., and Shiels, P.G. (2013) The in situ local immune response, tumour senescence and proliferation in colorectal cancer. British Journal of Cancer, 109(8), pp. 2207-2216. (doi:10.1038/bjc.2013.556)

Sebastián, C. et al. (2012) The histone deacetylase SIRT6 is a novel tumor suppressor that controls cancer metabolism. Cell, 151(6), pp. 1185-1199. (doi:10.1016/j.cell.2012.10.047)

McLean, J. et al. (2012) Early life socioeconomic status, chronic physiological stress and hippocampal N-acetyl aspartate concentrations. Behavioural Brain Research, 235(2), pp. 225-230. (doi:10.1016/j.bbr.2012.08.013)

Packard, C. et al. (2012) Interaction of personality traits with social deprivation in determining mental wellbeing and health behaviours. Journal of Public Health, 34(4), pp. 615-624. (doi:10.1093/pubmed/fds030)

Miller, A. M. et al. (2012) Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes? PLoS ONE, 7(10), e47830. (doi:10.1371/journal.pone.0047830)

Knox, S. et al. (2012) 25-hydroxyvitamin D is lower in deprived groups, but is not associated with carotid intima media thickness or plaques: results from pSoBid. Atherosclerosis, 223(2), pp. 437-441. (doi:10.1016/j.atherosclerosis.2012.05.001)

Robertson, T., Batty, G.D., Der, G., Green, M.J., McGlynn, L.M., McIntyre, A., Shiels, P.G., and Benzeval, M. (2012) Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 study. PLoS ONE, 7(7), e41805. (doi:10.1371/journal.pone.0041805)

Bossini-Castillo, L. et al. (2012) A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Human Molecular Genetics, 21(4), pp. 926-933. (doi:10.1093/hmg/ddr522)

McGuinness, D. et al. (2012) Socio-economic status is associated with epigenetic differences in the pSoBid cohort. International Journal of Epidemiology, 41(1), pp. 151-160. (doi:10.1093/ije/dyr215)

Alfred, T. et al. (2012) A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon Programme. PLoS ONE, 7(1), e29883. (doi:10.1371/journal.pone.0029883)

Bossini-Castillo, L. et al. (2012) KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor. Arthritis Research and Therapy, 14(6), R273. (doi:10.1186/ar4124)

Der, G., Batty, G.D., Benzeval, M., Deary, I.J., Green, M.J., McGlynn, L., McIntyre, A., Robertson, T., and Shiels, P.G. (2012) Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland? PLoS ONE, 7(9), e45166. (doi:10.1371/journal.pone.0045166)

Shiels, P.G. (2012) CDKN2A might be better than telomere length in determining individual health status. British Medical Journal, 344, e1415. (doi:10.1136/bmj.e1415)

Carmona, F.D. et al. (2011) Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis. Annals of the Rheumatic Diseases, 70(11), pp. 2050-2052. (doi:10.1136/ard.2010.148874)

Maxwell, F., McGlynn, L.M., Muir, H.C., Talwar, D., Benzeval, M., Robertson, T., Roxburgh, C.S., McMillan, D., Horgan, P.G., and Shiels, P. (2011) Telomere attrition and decreased Fetuin A levels indicate accelerated biological ageing and are implicated in the pathogenesis of colorectal cancer. Clinical Cancer Research, 17(17), pp. 5573-5581. (doi:10.1158/1078-0432.CCR-10-3271)

Bossini-Castillo, L. et al. (2011) A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort. Annals of the Rheumatic Diseases, 70(4), pp. 638-641. (doi:10.1136/ard.2010.141838)

Birnie, K. et al. (2011) Childhood socioeconomic position and objectively measured physical capability levels in adulthood: a systematic review and meta-analysis. PLoS ONE, 6(1), e15564. (doi:10.1371/journal.pone.0015564)

Bossini-Castillo, L. et al. (2011) Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population. Rheumatology, 50(11), pp. 1976-1981. (doi:10.1093/rheumatology/ker259)

McCarthy, M.I. et al. (2011) Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. PLoS Genetics, 7(7), e1002178. (doi:10.1371/journal.pgen.1002178)

McGuinness, D., McGuinness, D.H., McCaul, J., and Shiels, P.G. (2011) Sirtuins, bioageing, and cancer. Journal of Aging Research, 2011, p. 235754. (doi:10.4061/2011/235754)

Packard, C.J. et al. (2011) Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study. BMC Public Health, 11, p. 42. (doi:10.1186/1471-2458-11-42)

Shiels, P.G. et al. (2011) Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort. PLoS ONE, 6(7), e22521. (doi:10.1371/journal.pone.0022521)

Stevenson, K. et al. (2011) Pancreatic derived pathfinder cells enable regeneration of critically damaged adult pancreatic tissue and completely reverse streptozotocin induced diabetes. Rejuvenation Research, 14(2), pp. 163-171. (doi:10.1089/rej.2010.1099)

Cooper, R., Kuh, D., Hardy, R., and Mortality Review Group on behalf of the FALCon and HALCyon study teams, (2010) Objectively measured physical capability levels and mortality: systematic review and meta-analysis. British Medical Journal, 341, c4467. (doi:10.1136/bmj.c4467)

Elsberger, B., Fullerton, R., Zino, S., Jordan, F., Mitchell, T.J., Brunton, V.G., Mallon, E.A., Shiels, P.G., and Edwards, J. (2010) Breast cancer patients' clinical outcome measures are associated with Src kinase family member expression. British Journal of Cancer, 103(6), pp. 899-909. (doi:10.1038/sj.bjc.6605829)

Cooper, R., Kuh, D., Cooper, C., Gale, C. R., Lawlor, D. A., Matthews, F., Hardy, R., and FALCon and HALCyon , S. T. (2010) Objective measures of physical capability and subsequent health: a systematic review. Age and Ageing, 40(1), pp. 14-23. (doi:10.1093/ageing/afq117)

Radstake, T.R.D.J. et al. (2010) Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nature Genetics, 42(5), pp. 426-429. (doi:10.1038/ng.565)

Shiels, P.G. (2010) Improving precision in investigating aging: why telomeres can cause problems. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 65A(8), pp. 789-791. (doi:10.1093/gerona/glq095)

Simpson, R.J., Cosgrove, C., Chee, M.M., McFarlin, B.K., Bartlett, D.B., Spielmann, G., O'Connor, D.P., Pircher, H., and Shiels, P.G. (2010) Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans. Exercise Immunology Review, 16, pp. 40-55.

Stevenson, K.S., McGlynn, L.M., Hodge, M., McLinden, H., George, W.D., Davies, R.W., and Shiels, P.G. (2009) Isolation, characterization, and differentiation of Thy1.1-sorted pancreatic adult progenitor cell populations. Stem Cells and Development, 18(10), pp. 1389-1398. (doi:10.1089/scd.2008.0301)

Stevenson, K.S., McGlynn, L.M., and Shiels, P.G. (2009) Stem cells: outstanding potential and outstanding questions. Scottish Medical Journal, 54(4), pp. 35-37. (doi:10.1258/rsmsmj.54.4.35 )

Batty, G.D., Wang, Y., Brouilette, S.W., Shiels, P.G., Packard, C.J., Moore, J., Samani, N.J., and Ford, I. (2009) Socioeconomic status and telomere length: the West of Scotland Coronary Prevention Study. Journal of Epidemiology and Community Health , 63(10), pp. 839-841. (doi:10.1136/jech.2009.088427)

McGlynn, L.M., Stevenson, K., Lamb, K., Zino, S., Brown, M., Prina, A., Kingsmore, D., and Shiels, P.G. (2009) Cellular senescence in pre-transplant renal biopsies predicts postoperative organ function. Aging Cell, 8(1), pp. 45-51. (doi:10.1111/j.1474-9726.2008.00447.x)

Deans, K.A. et al. (2009) Differences in atherosclerosis according to area level socioeconomic deprivation: cross sectional, population based study. British Medical Journal, 339, b4170. (doi:10.1136/bmj.b4170)

El Fangour, S., Marini, M., Good, J., McQuaker, S.J., Shiels, P.G., and Hartley, R.C. (2009) Nitrones for understanding and ameliorating the oxidative stress associated with aging. Age, 31(4), pp. 269-276. (doi:10.1007/s11357-009-9098-z) (PMID:19479343) (PMCID:PMC2813050)

Maclntyre, A., Brouilette, S.W., Lamb, K., Radhakrishnan, K., McGlynn, L.M., Chee, M.M., Parkinson, E.K., Freeman, D., Madhok, R., and Shiels, P.G. (2008) Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion. Annals of the Rheumatic Diseases, 67(12), pp. 1780-1782. (doi:10.1136/ard.2007.086652)

Starr, J.M., Shiels, P.G., Harris, S.E., Pattie, A., Pearce, M.S., Relton, C.L., and Deary, I.J. (2008) Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. Mechanisms of Ageing and Development, 129(12), pp. 745-751. (doi:10.1016/j.mad.2008.09.020)

Carrero, J.J., Shiels, P.G., and Stenvinkel, P. (2008) Telomere biology alterations as a mortality risk factor in CKD. American Journal of Kidney Diseases, 51(6), pp. 1076-1077. (doi:10.1053/j.ajkd.2008.02.367)

Stevenson, K.S., Radhakrishnan, K., Patterson, C.S., McMillan, L.C., Skeldon, K.D., Buist, L., Padgett, M., and Shiels, P.G. (2008) Breath ethane peaks during a single haemodialysis session and is associated with time on dialysis. Journal of Breath Research, 2(2), 026004. (doi:10.1088/1752-7155/2/2/026004)

Carrero, J.J. et al. (2008) Telomere attrition is associated with inflammation, low fetuin-A levels and high mortality in prevalent haemodialysis patients. Journal of Internal Medicine, 263(3), pp. 302-312. (doi:10.1111/j.1365-2796.2007.01890.x)

Chee, M.M., MacIntyre, A., Brouilette, S.W., Madhok, R., and Shiels, P.G. (2008) Association of increased telomere lengths in scleroderma with no age-related telomere erosion. Rheumatology, 47(Sup. 2), ii23. (doi:10.1093/rheumatology/kem511)

Velupillai, Y.N. et al. (2008) Psychological, social and biological determinants of ill health (pSoBid): study protocol of a population-based study. BMC Public Health, 8(126), (doi:10.1186/1471-2458-8-126)

Patterson, C.S., McMillan, L.C., Stevenson, K., Radhakrishnan, K., Shiels, P.G., Padgett, M., and Skeldon, K.D. (2007) Dynamic study of oxidative stress in renal dialysis patients based on breath ethane measured by optical spectroscopy. Journal of Breath Research, 1(2), 026005. (doi:10.1088/1752-7155/1/2/026005)

Starr, J.M., McGurn, B., Harris, S.E., Whalley, L.J., Deary, I.J., and Shiels, P.G. (2007) Association between telomere length and heart disease in a narrow age cohort of older people. Experimental Gerontology, 42(6), pp. 571-573. (doi:10.1016/j.exger.2006.12.002)

Al Kushi, A., Russell, D., Shiels, P.G., Davies, R.W., and Payne, A.P. (2007) Lewy-body protein immunoreactivity in the midbrain of a PKC-gamma mutant rat. Journal of Anatomy, 210(5), pp. 606-607.

Carrero, J.J. et al. (2007) Telomere shortening, a new mortality risk factor in dialysis patients. Associations with inflammatory markers and fetuin-a levels. Blood Purification, 25(4), p. 338.

Russell, D., Shiels, P.G., and Payne, A.P. (2007) Effects of the agu mutation on ageing and senescence in the brain and kidney in vivo. Journal of Anatomy, 210(5), pp. 624-625.

Stevenson, K., and Shiels, P.G. (2007) Cellular therapy for diabetes. Dumfries and Galloway Medical Journal, 5, pp. 7-13.

Chen, D., Weber, M., Shiels, P.G., Dong, R., Webster, Z., Mcvey, J.H., Kemball-Cook, G., Tuddenham, E.G.D., Lechler, R.I., and Dorling, A. (2006) Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins. Journal of Thrombosis and Haemostasis, 4(10), pp. 2191-2198. (doi:10.1111/j.1538-7836.2006.02100.x)

Harris, S.E., Deary, I.J., Maclntyre, A., Lamb, K.J., Radhakrishnan, K., Starr, J.M., Whalley, L.J., and Shiels, P.G. (2006) The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people. Neuroscience Letters, 406(3), pp. 260-264. (doi:10.1016/j.neulet.2006.07.055)

Ashraf, N., Zino, S., MacIntyre, A., Kingsmore, D., Payne, A.P., George, W.D., and Shiels, P.G. (2006) Altered sirtuin expression is associated with node-positive breast cancer. British Journal of Cancer, 95, pp. 1056-1061. (doi:10.1038/sj.bjc.6603384)

Lamb, K., Stevenson, K.S., Zino, S., MacIntyre, A., Kingsmore, D., Jardine, A.G., Marson, L., Forsyth, J.L.R., and Shiels, P.G. (2006) Telomere binding protein expression correlates with cold ischemic time and late graft dysfunction in human renal allografts, as a result of accelerated organ senescence. Nephrology, Dialysis, Transplantation, 21, pp. 259-260.

Nolan, C.E., Melin, J., Marson, L., Forsyth, J.L.R., Jardine, A.G., and Shiels, P.G. (2006) Insulin protects from accelerated senescence secondary to ischaemia/reperfusion injury in STZ diabetic rats. Nephrology, Dialysis, Transplantation, 21, p. 4.

Sklavounou, E., Hay, A., Ashraf, N., Lamb, K., Brown, E., Mac Intyre, A., George, W.D., Hartley, R.C., and Shiels, P.G. (2006) The use of telomere biology to identify and develop superior nitrone based anti-oxidants. Biochemical and Biophysical Research Communications, 347, pp. 420-427. (doi:10.1016/j.bbrc.2006.06.087)

Al-Fayez, M., Russell, D., Wayne Davies, R., Shiels, P.G., and Baker, P. (2005) Deficits in the mid-brain raphe nuclei and striatum of the AS/AGU rat, a protein kinase C-gamma mutant. European Journal of Neuroscience, 22(11), pp. 2792-2798. (doi:10.1111/j.1460-9568.2005.04502.x)

Shiels, P.G., Mac Intyre, A., Chen, D., Dorling, A., Deardon, D., and Subrimaniam, M. (2005) IV administration of adult stem cells mitigates STZ induced diabetes in a xenotransplant model. American Journal of Transplantation, 5(S11), p. 369. (doi:10.1111/j.1600-6135.2005.authind.x)

Shiels, P.G. (2005) Adult stem cells mitigate the effects of STZ diabetes. Horizons in Medicine, 17, pp. 241-249.

Chen, D.X., Giannopoulos, K., Shiels, P.G., Webster, Z., Mcvey, J.H., Kemball-Cook, G., Tuddenham, E., Moore, M., Lechler, R., and Dorling, A. (2004) Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium. Blood, 104(5), pp. 1344-1349. (doi:10.1182/blood-2003-12-4365)

Hillyard, D.Z., Cameron, A.J.M., McDonald, K.J., Thomson, J., MacIntyre, A., Shiels, P.G., Panarelli, M., and Jardine, A.G. (2004) Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease. Atherosclerosis, 175(2), pp. 305-313. (doi:10.1016/j.atherosclerosis.2004.03.018)

Nolan, C.E., Wright, S.M., and Shiels, P.G. (2004) Senescence and transplantation. Transplant Topics, 15, pp. 6-9.

Joosten, S.A., van Ham, V., Nolan, C.E., Borrias, M.C., Jardine, A.G., Shiels, P.G., van Kooten, C., and Paul, L.C. (2003) Telomere shortening and cellular senescence in a model of chronic renal allograft rejection. American Journal of Pathology, 162(4), pp. 1305-1312. (doi:10.1016/S0002-9440(10)63926-0)

Shiels, P.G., and Jardine, A.G. (2003) Dolly, no longer the exception: Telomeres and implications for transplantation. Cloning Stem Cells, 5(2), pp. 157-160.

Ayres, D., Colman, A., Dai, Y., Shiels, P.G., and Moore, M. (2001) Cloning pigs deficient in alpha 1,3 galactosyltransferase. Graft, 4, pp. 80-82.

Craig, N.J. et al. (2001) A candidate gene for human neurodegenerative disorders: a rat PKCγ mutation causes a Parkinsonian syndrome. Nature Neuroscience, 4, pp. 1061-1062. (doi:10.1038/nn740 )

Shiels, P.G., Kind, A.J., Campbell, K.H.S., Wilmut, I., Waddington, D., Colman, A., and Schnieke, A.E. (1999) Analysis of telomere length in Dolly, a sheep derived by nuclear transfer. Cloning, 1(2), pp. 119-125. (doi:10.1089/15204559950020003)

Shiels, P. (1999) Somatic cell nuclear transfer as a tool for investigating ageing processes in mammals. Gene Therapy and Molecular Biology, 4, pp. 11-22.

Shiels, P.G., Kind, A.J., Campbell, K.H.S., Waddington, D., Wilmut, I., Colman, A., and Schnieke, A.E. (1999) Analysis of telomere lengths in cloned sheep. Nature, 399(6734), pp. 316-317. (doi:10.1038/20580)

Book Sections

Lamb, K.J., and Shiels, P.G. (2009) Telomeres, ageing and oxidation. In: Foyer, C.H., Faragher, R. and Thornally, P.J. (eds.) Redox Metabolism and Longevity Relationships in Animals and Plants. Series: SEB experimental biology series (62). Taylor and Francis: New York, USA, pp. 117-137. ISBN 9780415419543

Shiels, P.G., and Davies, R.W. (2004) Ageing and death in neurones. In: Davies, R.W. and Morris, B.J. (eds.) Molecular Biology of the Neuron. Series: Molecular and cellular neurobiology series. Oxford University Press: Oxford, UK, pp. 435-464. ISBN 9780198509981

Conference Proceedings

Gardani, M., McMillan, T., Shiels, P., McGlynn, L., and Stewart, E. (2012) An investigation of biological ageing processes following head injury. In: International Brain Injury Association's Ninth World Congress on Brain Injury, Edinburgh, UK, 21-25 Mar 2012, pp. 309-799. (doi:10.3109/02699052.2012.660091)

Shiels, P.G. (2000) Innovations conceptuelles et technologieques a l'aube du trosième millenaire. In: Dimanches biologiques de Lariboisière, Paris, 16-18 Nov 2000, pp. 73-80.

This list was generated on Tue Jun 30 04:58:44 2015 BST.