Number of items: 11.
2012
Calaminus, S.D.J., Guitart, A., Sinclair, A., Schachtner, H., Watson, S.P., Holyoake, T.L., Kranc, K.R., and Machesky, L.M.
(2012)
Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny.
PLoS ONE, 7
(12).
e51361.
ISSN 1932-6203
(doi:10.1371/journal.pone.0051361)
2011
Mortensen, M. et al.
(2011)
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.
Journal of Experimental Medicine, 208
(3).
pp. 455-467.
ISSN 0022-1007
(doi:10.1084/jem.20101145)
2010
Pollard, P.J., and Kranc, K.R.
(2010)
Hypoxia Signaling in Hematopoietic Stem Cells: A Double-Edged Sword.
Cell Stem Cell, 7
(3).
pp. 276-278.
ISSN 1934-5909
(doi:10.1016/j.stem.2010.08.006)
2009
Kranc, K.R, Schepers, H., Rodrigues, N.P., Bamforth, S., Villadsen, E., Ferry, H., Bouriez-Jones, T., Sigvardsson, M., Bhattacharya, S., and Jacobsen, S.E.
(2009)
Cited2 is an essential regulator of adult hematopoietic stem cells.
Cell Stem Cell, 5
(6).
pp. 659-665.
ISSN 1934-5909
(doi:10.1016/j.stem.2009.11.001)
Harkiolaki, M. et al.
(2009)
T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides.
Immunity, 30
(3).
pp. 348-357.
ISSN 1074-7613
(doi:10.1016/j.immuni.2009.01.009)
2006
Gregersen, J.W., Kranc, K.R., Ke, X., Svendsen, P., Madsen, L.S., Thomsen, A.R., Cardon, L.R., Bell, J.I., and Fugger, L.
(2006)
Functional epistasis on a common MHC haplotype associated with multiple sclerosis.
Nature, 443
.
pp. 574-577.
ISSN 0028-0836
(doi:10.1038/nature05133)
2005
Kranc, K., Taylor, A.M., Willcox, N., and Fugger, L.
(2005)
Control of autoimmunity by 'epitope theft'.
Trends in Molecular Medicine, 11
(1).
pp. 1-4.
ISSN 1471-4914
(doi:10.1016/j.molmed.2004.11.002)
2003
Kranc, K.R., Bamforth, S.D., Braganca, J., Norbury, C., van Lohuizen, M., and Bhattacharya, S.
(2003)
Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF.
Molecular and Cellular Biology, 23
(21).
pp. 7658-7666.
ISSN 0270-7306
(doi:10.1128/MCB.23.21.7658-7666.2003)
2001
Bamforth, S.D., Bragança, J., Eloranta, J.J., Murdoch, J.N., Marques, F.I.R., Kranc, K.R., Farza, H., Henderson, D.J., Hurst, H.C., and Bhattacharya, S.
(2001)
Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.
Nature Genetics, 29
(4).
pp. 469-474.
ISSN 1061-4036
(doi:10.1038/ng768)
Kranc, K.R., Pyne, G.J., Tao, L., Claridge, T.D.W., Harris, D.A., Cadoux-Hudson, T.A.D., Turnbull, J.J., Schofield, C.J., and Clark, J.F.
(2001)
Oxidative degradation of bilirubin produces vasoactive compounds.
European Journal of Biochemistry, 267
(24).
pp. 7094-7101.
ISSN 0014-2956
(doi:10.1046/j.1432-1327.2000.01812.x)
1999
Clark, J.F., and Kranc, K.R.
(1999)
The role of the mitochondrion in smooth muscle cell fate choices of proliferation versus apoptosis during vascular and cardiovascular diseases.
Expert Opinion on Therapeutic Targets, 3
(4).
pp. 513-525.
ISSN 1472-8222
(doi:10.1517/14728222.3.4.513)
This list was generated on Fri May 24 15:20:31 2013 BST.
Leukaemia is a devastating disease of the haematopoietic system. The disease develops when mechanisms controlling normal blood production (haematopoiesis) become corrupted. Haematopoiesis critically depends on rare bone marrow (BM)-resident hematopoietic stem cells (HSCs). HSCs possess multiple cell fate choices - they can self-renew, undergo apoptosis, remain quiescent or differentiate into blood lineages. Leukaemia-causing cancer stem cells arise from HSCs or progenitor cells that have gained increased self-renewal and survival capacity and give rise to leukaemic cells. We investigate the regulatory pathways controlling stem cell fate decisions and attempt to understand how these pathways are corrupted to cause leukaemia. We believe that better understanding of cellular and molecular mechanisms underlying stem cell fate decisions will be instrumental in identifying novel therapeutic targets to eradicate cancer stem cells and inhibit leukaemic cell growth.