Professor Eyal Gottlieb

  • Director of the Beatson Cancer Metabolism Research Unit (Beatson Institute for Cancer Research)

Research interests

Energy metabolism is defined as the reactions from which cells obtain and expend ATP. Our lab investigates the role of altered energy metabolism in supporting cancer development and in regulating cell death. The major routes of ATP generation in cells are glycolysis in the cytosol and oxidative phosphorylation in mitochondria. Although tightly-controlled energy metabolism is fundamental to survival, many types of cancer paradoxically exhibit abnormal glycolysis or mitochondrial activity in the face of high growth and proliferation rates. In fact, in cancer cells ATP can be predominantly derived from glycolysis, a significantly less efficient route of ATP production compared to oxidative phosphorylation.

Link to Apoptosis and Tumour Metabolism website

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Optimising the use of chemotherapy in prostate cancer
    Prostate Cancer Foundation
    2015 - 2017
     
  • Identifying Novel Targets for eradication of acute lymphoblastic leukaemia in the central nervous system
    Scottish Executive Health Department
    2015 - 2016
     
  • Clinical Research Fellow Funding
    The Beatson Institute for Cancer Research
    2014 - 2015
     
  • Metabolic vulnerabilities induced by Myc
    Cancer Research UK
    2012 - 2013
     

Publications

List by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005
Number of items: 64.

2016

Trousil, S. et al. (2016) The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth. Oncotarget, 7(24), pp. 37103-37120. (doi:10.18632/oncotarget.9466) (PMID:27206796)

Karvela, M. et al. (2016) ATG7 regulates energy metabolism, differentiation and survival of Philadelphia chromosome-positive cells. Autophagy, (doi:10.1080/15548627.2016.1162359) (PMID:27168493) (Early Online Publication)

Tumanov, S., Bulusu, V., Gottlieb, E., and Kamphorst, J. (2016) A rapid method for quantifying free and bound acetate based on alkylation and GC-MS analysis. Cancer and Metabolism, (Accepted for Publication)

Schug, Z. T., Vande Voorde, J., and Gottlieb, E. (2016) The nurture of tumors can drive their metabolic phenotype. Cell Metabolism, 23(3), pp. 391-392. (doi:10.1016/j.cmet.2016.02.016) (PMID:26959177)

Cagan, R., and Gottlieb, E. (2016) In memory of Marcos Vidal (1974-2016). Disease Models and Mechanisms, 9(3), p. 233. (doi:10.1242/dmm.024612) (PMID:26758990)

Baenke, F. et al. (2016) Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells. Molecular Oncology, 10(1), pp. 73-84. (doi:10.1016/j.molonc.2015.08.003) (PMID:26365896) (PMCID:PMC4717845)

van der Reest, J., and Gottlieb, E. (2016) Anti-cancer effects of vitamin C revisited. Cell Research, 26(3), pp. 269-270. (doi:10.1038/cr.2016.7) (PMID:26768769)

2015

Tardito, S. et al. (2015) Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nature Cell Biology, 17(12), pp. 1556-1568. (doi:10.1038/ncb3272) (PMID:26595383)

Buescher, J. M. et al. (2015) A roadmap for interpreting 13C metabolite labeling patterns from cells. Current Opinion in Biotechnology, 34, pp. 189-201. (doi:10.1016/j.copbio.2015.02.003) (PMID:25731751) (PMCID:PMC4552607)

Patella, F. et al. (2015) Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability. Molecular and Cellular Proteomics, 14(3), pp. 621-634. (doi:10.1074/mcp.M114.045575) (PMID:25573745) (PMCID:PMC4349982)

Schug, Z. T. et al. (2015) Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell, 27(1), pp. 57-71. (doi:10.1016/j.ccell.2014.12.002)

Fack, F. et al. (2015) Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas. Acta Neuropathologica, 129(1), pp. 115-131. (doi:10.1007/s00401-014-1352-5)

Cadalbert, L.C., Ghaffar, F.N., Stevenson, D., Bryson, S., Vaz, F.M., Gottlieb, E., and Strathdee, D. (2015) Mouse tafazzin is required for male germ cell meiosis and spermatogenesis. PLoS ONE, 10(6), e0131066. (doi:10.1371/journal.pone.0131066) (PMID:26114544) (PMCID:PMC4483168)

Cardaci, S. et al. (2015) Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis. Nature Cell Biology, 17, pp. 1317-1326. (doi:10.1038/ncb3233) (PMID:26302408)

Kluckova, K., Sticha, M., Cerny, J., Mracek, T., Dong, L., Drahota, Z., Gottlieb, E., Neuzil, J., and Rohlena, J. (2015) Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death and Disease, 6(5), e1749. (doi:10.1038/cddis.2015.110) (PMID:25950479)

Mackay, G. M., Zheng, L., Van Den Broek, N. J.F., and Gottlieb, E. (2015) Analysis of cell metabolism using LC-MS and isotope tracers. Methods in Enzymology, 561, pp. 171-196. (doi:10.1016/bs.mie.2015.05.016) (PMID:26358905)

Olivares, O., Däbritz, J. H. M., King, A., Gottlieb, E., and Halsey, C. (2015) Research into cancer metabolomics: towards a clinical metamorphosis. Seminars in Cell and Developmental Biology, 43, pp. 52-64. (doi:10.1016/j.semcdb.2015.09.008) (PMID:26365277)

Yizhak, K., Chaneton, B., Gottlieb, E., and Ruppin, E. (2015) Modeling cancer metabolism on a genome scale. Molecular Systems Biology, 11(6), 817. (doi:10.15252/msb.20145307) (PMID:26130389) (PMCID:PMC4501850)

Zheng, L. et al. (2015) Fumarate induces redox-dependent senescence by modifying glutathione metabolism. Nature Communications, 6, 6001. (doi:10.1038/ncomms7001) (PMID:25613188) (PMCID:PMC4340546)

2014

Witney, T. H. et al. (2014) Preclinical evaluation of 3-18F-Fluoro-2,2-dimethylpropionic acid as an imaging agent for tumor detection. Journal of Nuclear Medicine, 55(9), pp. 1506-1512. (doi:10.2967/jnumed.114.140343)

Jerby-Arnon, L. et al. (2014) Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality. Cell, 158(5), pp. 1199-1209. (doi:10.1016/j.cell.2014.07.027)

2013

Morita, M. et al. (2013) mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metabolism, 18(5), pp. 698-711. (doi:10.1016/j.cmet.2013.10.001)

Gonzalvez, F. et al. (2013) Barth syndrome: cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin (TAZ) gene mutation. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1832(8), pp. 1194-1206. (doi:10.1016/j.bbadis.2013.03.005) (PMID:23523468)

Kaplon, J. et al. (2013) A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature, 498(7452), pp. 109-112. (doi:10.1038/nature12154)

Long, J.S., Crighton, D., O’Prey, J., MacKay, G., Zheng, L., Palmer, T.M., Gottlieb, E., and Ryan, K.M. (2013) Extracellular adenosine sensing—a metabolic cell death priming mechanism downstream of p53. Molecular Cell, 50(3), pp. 394-406. (doi:10.1016/j.molcel.2013.03.016)

Tannahill, G.M. et al. (2013) Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature, 496(7444), pp. 238-242. (doi:10.1038/nature11986)

Maddocks, O.D.K., Berkers, C.R., Mason, S.M., Zheng, L., Blyth, K., Gottlieb, E., and Vousden, K.H. (2013) Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature, 493(7433), pp. 542-546. (doi:10.1038/nature11743)

Duran, R.V., MacKenzie, E.D., Boulahbel, H., Frezza, C., Heiserich, L., Tardito, S., Rocha, S., Hall, M.N., and Gottlieb, E. (2013) HIF-independent role of Prolyl Hydroxylases in the cellular response to amino acids. Oncogene, 32(38), pp. 4549-4556. (doi:10.1038/onc.2012.465)

Jalmar, O. et al. (2013) Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid. PLoS ONE, 8(2), e55250. (doi:10.1371/journal.pone.0055250)

Rosenfeldt, M.T. et al. (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature, 504(7479), pp. 296-300. (doi:10.1038/nature12865)

2012

Chaneton, B., and Gottlieb, E. (2012) PGAMgnam style: a glycolytic switch controls biosynthesis. Cancer Cell, 22(5), pp. 565-566. (doi:10.1016/j.ccr.2012.10.014)

Chaneton, B. et al. (2012) Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature, 491(7424), pp. 458-462. (doi:10.1038/nature11540)

Chaneton, B., and Gottlieb, E. (2012) Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer. Trends in Biochemical Sciences, 37(8), pp. 309-316. (doi:10.1016/j.tibs.2012.04.003)

Duran, R.V., Oppliger, W., Robitaille, A.M., Heiserich, L., Skendaj, R., Gottlieb, E., and Hall, M.N. (2012) Glutaminolysis activates Rag-mTORC1 signaling. Molecular Cell, 47(3), pp. 349-358. (doi:10.1016/j.molcel.2012.05.043)

Galluzzi, L. et al. (2012) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death and Differentiation, 19(1), pp. 107-120. (doi:10.1038/cdd.2011.96)

Schug, Z.T., Frezza, C., Galbraith, L.C.A., and Gottlieb, E. (2012) The music of lipids: how lipid composition orchestrates cellular behaviour. Acta Oncologica, 51(3), pp. 301-310. (doi:10.3109/0284186X.2011.643823)

2011

Frezza, C. et al. (2011) Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature, 477(7363), pp. 225-228. (doi:10.1038/nature10363)

Folger, O., Jerby, L., Frezza, C., Gottlieb, E., Ruppin, E., and Shlomi, T. (2011) Predicting selective drug targets in cancer through metabolic networks. Molecular Systems Biology, 7, p. 517. (doi:10.1038/msb.2011.51)

Frezza, C., Pollard, P.J., and Gottlieb, E. (2011) Inborn and acquired metabolic defects in cancer. Journal of Molecular Medicine, 89(3), pp. 213-220. (doi:10.1007/s00109-011-0728-4)

Folger, O., Jerby, L., Frezza, C., Gottlieb, E., Ruppin, E., and Shlomi, T. (2011) Predicting selective drug targets in cancer through metabolic networks. Molecular Systems Biology, 7, p. 501. (doi:10.1038/msb.2011.35)

Frezza, C., Zheng, L., Tennant, D.A., Papkovsky, D.B., Hedley, B., Kalna, G., Watson, D.G., and Gottlieb, E. (2011) Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival. PLoS ONE, 6(9), e24411. (doi:10.1371/journal.pone.0024411)

Gottlieb, E. (2011) p53 guards the metabolic pathway less travelled. Nature Cell Biology, 13(3), pp. 195-197. (doi:10.1038/ncb2177)

Schug, Z.T., Gonzalvez, F., Houtkooper, R.H., Vaz, F.M., and Gottlieb, E. (2011) BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane. Cell Death and Differentiation, 18(3), pp. 538-548. (doi:10.1038/cdd.2010.135)

Shlomi, T., Benyamini, T., Gottlieb, E., Sharan, R., and Ruppin, E. (2011) Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect. PLoS Computational Biology, 7(3), e1002018. (doi:10.1371/journal.pcbi.1002018)

2010

Frezza, C., Tennant, D.A., and Gottlieb, E. (2010) IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip. Cancer Cell, 17(1), pp. 7-9. (doi:10.1016/j.ccr.2009.12.031)

Gottlieb, E., and Vousden, K. H. (2010) p53 Regulation of Metabolic Pathways. Cold Spring Harbor Perspectives in Biology, 2(4), a001040. (doi:10.1101/cshperspect.a001040)

Tennant, D.A., Duran, R.V., and Gottlieb, E. (2010) Targeting metabolic transformation for cancer therapy. Nature Reviews Cancer, 10(4), pp. 267-277. (doi:10.1038/nrc2817)

Tennant, D.A., and Gottlieb, E. (2010) HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression. Journal of Molecular Medicine, 88(8), pp. 839-849. (doi:10.1007/s00109-010-0627-0)

2009

Boulahbel, H., Duran, R.V., and Gottlieb, E. (2009) Prolyl hydroxylases as regulators of cell metabolism. Biochemical Society Transactions, 37(1), pp. 291-294. (doi:10.1042/BST0370291)

Frezza, C., and Gottlieb, E. (2009) Mitochondria in cancer: Not just innocent bystanders. Seminars in Cancer Biology, 19(1), pp. 4-11. (doi:10.1016/j.semcancer.2008.11.008)

Gottlieb, E. (2009) Cancer: The fat and the furious. Nature, 461(7260), pp. 44-45. (doi:10.1038/461044a)

King, A., and Gottlieb, E. (2009) Glucose metabolism and programmed cell death: an evolutionary and mechanistic perspective. Current Opinion in Cell Biology, 21(6), pp. 885-893. (doi:10.1016/j.ceb.2009.09.009)

Schug, Z.T., and Gottlieb, E. (2009) Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis. Biochimica et Biophysica Acta: Biomembranes, 1788(10), pp. 2022-2031. (doi:10.1016/j.bbamem.2009.05.004)

Tennant, D. A., Duran, R. V., Boulahbel, H., and Gottlieb, E. (2009) Metabolic transformation in cancer. Carcinogenesis, 30(8), pp. 1269-1280. (doi:10.1093/carcin/bgp070)

Tennant, D.A. et al. (2009) Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death. Oncogene, 28(45), pp. 4009-4021. (doi:10.1038/onc.2009.250)

2008

Gonzalvez, F., Schug, Z.T., Houtkooper, R. H., MacKenzie, E. D., Brooks, D. G., Wanders, R. J.A., Petit, P. X., Vaz, F. M., and Gottlieb, E. (2008) Cardiolipin provides an essential activating platform for caspase-8 on mitochondria. Journal of Cell Biology, 183(4), pp. 681-696. (doi:10.1083/jcb.200803129)

2007

Gottlieb, E., and Gonzalvez, F. (2007) Cardiolipin: Setting the beat of apoptosis. Apoptosis, 12(5), pp. 877-885. (doi:10.1007/s10495-007-0718-8)

MacKenzie, E., Selak, M., Tennant, D., Payne, L., Crosby, S., Frederiksen, C., Watson, D., and Gottlieb, E. (2007) Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Molecular and Cellular Biology, 27(9), pp. 3282-3289. (doi:10.1128/MCB.01927-06)

2006

Bensaad, K., Tsuruta, A., Selak, M., Vidal, M., Nakano, K., Bartrons, R., Gottlieb, E., and Vousden, K. (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell, 126(1), pp. 107-120. (doi:10.1016/j.cell.2006.05.036)

Gottlieb, E. (2006) OPA1 and PARL keep a lid on apoptosis. Cell, 126(1), pp. 27-29. (doi:10.1016/j.cell.2006.06.030)

King, A., Selak, M., and Gottlieb, E. (2006) Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Oncogene, 25(34), pp. 4675-4682. (doi:10.1038/sj.onc.1209594)

Selak, M.A., Duran, R.V., and Gottlieb, E. (2006) Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells. Biochimica et Biophysica Acta: Bioenergetics, 1757(5-6), pp. 567-572. (doi:10.1016/j.bbabio.2006.05.015)

2005

Gottlieb, E., and Tomlinson, I. (2005) Mitochondrial tumour suppressors: A genetic and biochemical update. Nature Reviews Cancer, 5(11), pp. 857-866. (doi:10.1038/nrc1737)

Selak, M., Armour, S., MacKenzie, E., Boulahbel, H., Watson, D., Mansfield, K., Pan, Y., Simon, M., Thompson, C., and Gottlieb, E. (2005) Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell, 7(1), pp. 77-85. (doi:10.1016/j.ccr.2004.11.022)

This list was generated on Mon Jul 25 19:23:13 2016 BST.
Jump to: Articles
Number of items: 64.

Articles

Trousil, S. et al. (2016) The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth. Oncotarget, 7(24), pp. 37103-37120. (doi:10.18632/oncotarget.9466) (PMID:27206796)

Karvela, M. et al. (2016) ATG7 regulates energy metabolism, differentiation and survival of Philadelphia chromosome-positive cells. Autophagy, (doi:10.1080/15548627.2016.1162359) (PMID:27168493) (Early Online Publication)

Tumanov, S., Bulusu, V., Gottlieb, E., and Kamphorst, J. (2016) A rapid method for quantifying free and bound acetate based on alkylation and GC-MS analysis. Cancer and Metabolism, (Accepted for Publication)

Schug, Z. T., Vande Voorde, J., and Gottlieb, E. (2016) The nurture of tumors can drive their metabolic phenotype. Cell Metabolism, 23(3), pp. 391-392. (doi:10.1016/j.cmet.2016.02.016) (PMID:26959177)

Cagan, R., and Gottlieb, E. (2016) In memory of Marcos Vidal (1974-2016). Disease Models and Mechanisms, 9(3), p. 233. (doi:10.1242/dmm.024612) (PMID:26758990)

Baenke, F. et al. (2016) Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells. Molecular Oncology, 10(1), pp. 73-84. (doi:10.1016/j.molonc.2015.08.003) (PMID:26365896) (PMCID:PMC4717845)

van der Reest, J., and Gottlieb, E. (2016) Anti-cancer effects of vitamin C revisited. Cell Research, 26(3), pp. 269-270. (doi:10.1038/cr.2016.7) (PMID:26768769)

Tardito, S. et al. (2015) Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nature Cell Biology, 17(12), pp. 1556-1568. (doi:10.1038/ncb3272) (PMID:26595383)

Buescher, J. M. et al. (2015) A roadmap for interpreting 13C metabolite labeling patterns from cells. Current Opinion in Biotechnology, 34, pp. 189-201. (doi:10.1016/j.copbio.2015.02.003) (PMID:25731751) (PMCID:PMC4552607)

Patella, F. et al. (2015) Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability. Molecular and Cellular Proteomics, 14(3), pp. 621-634. (doi:10.1074/mcp.M114.045575) (PMID:25573745) (PMCID:PMC4349982)

Schug, Z. T. et al. (2015) Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell, 27(1), pp. 57-71. (doi:10.1016/j.ccell.2014.12.002)

Fack, F. et al. (2015) Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas. Acta Neuropathologica, 129(1), pp. 115-131. (doi:10.1007/s00401-014-1352-5)

Cadalbert, L.C., Ghaffar, F.N., Stevenson, D., Bryson, S., Vaz, F.M., Gottlieb, E., and Strathdee, D. (2015) Mouse tafazzin is required for male germ cell meiosis and spermatogenesis. PLoS ONE, 10(6), e0131066. (doi:10.1371/journal.pone.0131066) (PMID:26114544) (PMCID:PMC4483168)

Cardaci, S. et al. (2015) Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis. Nature Cell Biology, 17, pp. 1317-1326. (doi:10.1038/ncb3233) (PMID:26302408)

Kluckova, K., Sticha, M., Cerny, J., Mracek, T., Dong, L., Drahota, Z., Gottlieb, E., Neuzil, J., and Rohlena, J. (2015) Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death and Disease, 6(5), e1749. (doi:10.1038/cddis.2015.110) (PMID:25950479)

Mackay, G. M., Zheng, L., Van Den Broek, N. J.F., and Gottlieb, E. (2015) Analysis of cell metabolism using LC-MS and isotope tracers. Methods in Enzymology, 561, pp. 171-196. (doi:10.1016/bs.mie.2015.05.016) (PMID:26358905)

Olivares, O., Däbritz, J. H. M., King, A., Gottlieb, E., and Halsey, C. (2015) Research into cancer metabolomics: towards a clinical metamorphosis. Seminars in Cell and Developmental Biology, 43, pp. 52-64. (doi:10.1016/j.semcdb.2015.09.008) (PMID:26365277)

Yizhak, K., Chaneton, B., Gottlieb, E., and Ruppin, E. (2015) Modeling cancer metabolism on a genome scale. Molecular Systems Biology, 11(6), 817. (doi:10.15252/msb.20145307) (PMID:26130389) (PMCID:PMC4501850)

Zheng, L. et al. (2015) Fumarate induces redox-dependent senescence by modifying glutathione metabolism. Nature Communications, 6, 6001. (doi:10.1038/ncomms7001) (PMID:25613188) (PMCID:PMC4340546)

Witney, T. H. et al. (2014) Preclinical evaluation of 3-18F-Fluoro-2,2-dimethylpropionic acid as an imaging agent for tumor detection. Journal of Nuclear Medicine, 55(9), pp. 1506-1512. (doi:10.2967/jnumed.114.140343)

Jerby-Arnon, L. et al. (2014) Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality. Cell, 158(5), pp. 1199-1209. (doi:10.1016/j.cell.2014.07.027)

Morita, M. et al. (2013) mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metabolism, 18(5), pp. 698-711. (doi:10.1016/j.cmet.2013.10.001)

Gonzalvez, F. et al. (2013) Barth syndrome: cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin (TAZ) gene mutation. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1832(8), pp. 1194-1206. (doi:10.1016/j.bbadis.2013.03.005) (PMID:23523468)

Kaplon, J. et al. (2013) A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature, 498(7452), pp. 109-112. (doi:10.1038/nature12154)

Long, J.S., Crighton, D., O’Prey, J., MacKay, G., Zheng, L., Palmer, T.M., Gottlieb, E., and Ryan, K.M. (2013) Extracellular adenosine sensing—a metabolic cell death priming mechanism downstream of p53. Molecular Cell, 50(3), pp. 394-406. (doi:10.1016/j.molcel.2013.03.016)

Tannahill, G.M. et al. (2013) Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature, 496(7444), pp. 238-242. (doi:10.1038/nature11986)

Maddocks, O.D.K., Berkers, C.R., Mason, S.M., Zheng, L., Blyth, K., Gottlieb, E., and Vousden, K.H. (2013) Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature, 493(7433), pp. 542-546. (doi:10.1038/nature11743)

Duran, R.V., MacKenzie, E.D., Boulahbel, H., Frezza, C., Heiserich, L., Tardito, S., Rocha, S., Hall, M.N., and Gottlieb, E. (2013) HIF-independent role of Prolyl Hydroxylases in the cellular response to amino acids. Oncogene, 32(38), pp. 4549-4556. (doi:10.1038/onc.2012.465)

Jalmar, O. et al. (2013) Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid. PLoS ONE, 8(2), e55250. (doi:10.1371/journal.pone.0055250)

Rosenfeldt, M.T. et al. (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature, 504(7479), pp. 296-300. (doi:10.1038/nature12865)

Chaneton, B., and Gottlieb, E. (2012) PGAMgnam style: a glycolytic switch controls biosynthesis. Cancer Cell, 22(5), pp. 565-566. (doi:10.1016/j.ccr.2012.10.014)

Chaneton, B. et al. (2012) Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature, 491(7424), pp. 458-462. (doi:10.1038/nature11540)

Chaneton, B., and Gottlieb, E. (2012) Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer. Trends in Biochemical Sciences, 37(8), pp. 309-316. (doi:10.1016/j.tibs.2012.04.003)

Duran, R.V., Oppliger, W., Robitaille, A.M., Heiserich, L., Skendaj, R., Gottlieb, E., and Hall, M.N. (2012) Glutaminolysis activates Rag-mTORC1 signaling. Molecular Cell, 47(3), pp. 349-358. (doi:10.1016/j.molcel.2012.05.043)

Galluzzi, L. et al. (2012) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death and Differentiation, 19(1), pp. 107-120. (doi:10.1038/cdd.2011.96)

Schug, Z.T., Frezza, C., Galbraith, L.C.A., and Gottlieb, E. (2012) The music of lipids: how lipid composition orchestrates cellular behaviour. Acta Oncologica, 51(3), pp. 301-310. (doi:10.3109/0284186X.2011.643823)

Frezza, C. et al. (2011) Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature, 477(7363), pp. 225-228. (doi:10.1038/nature10363)

Folger, O., Jerby, L., Frezza, C., Gottlieb, E., Ruppin, E., and Shlomi, T. (2011) Predicting selective drug targets in cancer through metabolic networks. Molecular Systems Biology, 7, p. 517. (doi:10.1038/msb.2011.51)

Frezza, C., Pollard, P.J., and Gottlieb, E. (2011) Inborn and acquired metabolic defects in cancer. Journal of Molecular Medicine, 89(3), pp. 213-220. (doi:10.1007/s00109-011-0728-4)

Folger, O., Jerby, L., Frezza, C., Gottlieb, E., Ruppin, E., and Shlomi, T. (2011) Predicting selective drug targets in cancer through metabolic networks. Molecular Systems Biology, 7, p. 501. (doi:10.1038/msb.2011.35)

Frezza, C., Zheng, L., Tennant, D.A., Papkovsky, D.B., Hedley, B., Kalna, G., Watson, D.G., and Gottlieb, E. (2011) Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival. PLoS ONE, 6(9), e24411. (doi:10.1371/journal.pone.0024411)

Gottlieb, E. (2011) p53 guards the metabolic pathway less travelled. Nature Cell Biology, 13(3), pp. 195-197. (doi:10.1038/ncb2177)

Schug, Z.T., Gonzalvez, F., Houtkooper, R.H., Vaz, F.M., and Gottlieb, E. (2011) BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane. Cell Death and Differentiation, 18(3), pp. 538-548. (doi:10.1038/cdd.2010.135)

Shlomi, T., Benyamini, T., Gottlieb, E., Sharan, R., and Ruppin, E. (2011) Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect. PLoS Computational Biology, 7(3), e1002018. (doi:10.1371/journal.pcbi.1002018)

Frezza, C., Tennant, D.A., and Gottlieb, E. (2010) IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip. Cancer Cell, 17(1), pp. 7-9. (doi:10.1016/j.ccr.2009.12.031)

Gottlieb, E., and Vousden, K. H. (2010) p53 Regulation of Metabolic Pathways. Cold Spring Harbor Perspectives in Biology, 2(4), a001040. (doi:10.1101/cshperspect.a001040)

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Tennant, D.A., and Gottlieb, E. (2010) HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression. Journal of Molecular Medicine, 88(8), pp. 839-849. (doi:10.1007/s00109-010-0627-0)

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Schug, Z.T., and Gottlieb, E. (2009) Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis. Biochimica et Biophysica Acta: Biomembranes, 1788(10), pp. 2022-2031. (doi:10.1016/j.bbamem.2009.05.004)

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Gottlieb, E., and Gonzalvez, F. (2007) Cardiolipin: Setting the beat of apoptosis. Apoptosis, 12(5), pp. 877-885. (doi:10.1007/s10495-007-0718-8)

MacKenzie, E., Selak, M., Tennant, D., Payne, L., Crosby, S., Frederiksen, C., Watson, D., and Gottlieb, E. (2007) Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Molecular and Cellular Biology, 27(9), pp. 3282-3289. (doi:10.1128/MCB.01927-06)

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Gottlieb, E. (2006) OPA1 and PARL keep a lid on apoptosis. Cell, 126(1), pp. 27-29. (doi:10.1016/j.cell.2006.06.030)

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Selak, M., Armour, S., MacKenzie, E., Boulahbel, H., Watson, D., Mansfield, K., Pan, Y., Simon, M., Thompson, C., and Gottlieb, E. (2005) Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell, 7(1), pp. 77-85. (doi:10.1016/j.ccr.2004.11.022)

This list was generated on Mon Jul 25 19:23:13 2016 BST.