Dr Stephen Larcombe

  • Research Associate (Institute of Biodiversity Animal Health and Comparative Medicine)

Biography

2014-current: Research Associate, Molecular Epidemiology of Theileria annulata in India, University of Glasgow

2011-2014: Junior Research Fellowship, Impacts of Mosquito Control on Epidemiology of Avian Malaria in the Camagre, University of Oxford, Fondation Tour du Valat (France)

2010-2011: Postdoctoral Researcher: Host-parasite interactions in a Plasmodium-Canary system, University of Burgundy, France

2008-2010: PhD: Roles of Dietary Antioxidants and Oxitive Stress in Mediating Life-History Trade-Offs in Birds, University of Glasgow

Research interests

Most of my research focusses on Apicomplexan parasites; avian malaria in birds, mosquitoes and midges, and Theileria annulata in cows, buffaloes and ticks. My research is aimed at addressing interactions among host, parasite and vector, and hows these impact two main themes: consequences of infection with different parasites on the host and how these vary at an individual level, and the large scale drivers of differences in parasite prevalence in hosts.

In Theileria, working with my supervisor Brian Shiels and our collaborators in India we are investigating several questions: what are the intrinsic and extrinsic factors that impact difference in prevalence between the three main host types: native breed cattle, cross bred cattle, and buffaloes? Which genetic processes are important to determining differences in breed specific resistance to Theileria infection? And can bioinformatic predictions be used to generate candidate antigen genes for use in a broad spectrum transmission-blocking vaccine?

In avian malaria, my research on canaries with Garbiele Sorci has previously demonstrated prevalence-mediated virulence or a parasite, for the first time in a social vertebrate host. I also showed that dominance status can impact on the virulence of identical parasite challenge, irrespective of diet quality and competition. Work carried out with my collaborators has also shown  that diet quality in hosts can impact infection-dynamics of parasites in new hosts. I have also investigated the role that large-scale control of mosquitoes can have of the prevalence and diveristy of malaria in wild sparrows. I am currently developing a new research project aimed at addressing the role of seasonality in malaria infection dynamics.

My other main research interest is the role of antioxidants and oxidative stress underlying life-history trade-offs. My work has shown that exercise is a signficant source of oxidative damage in captive birds, and that diet and training can ameliorate this damage; that different lipid-soluble dietary antioxidants can have differential impacts on fitness related traits (including oxidative stress) in wild birds; and that seasonal variation in antioxidant quality of insect prey of birds is substantial.

Publications

List by: Type | Date

Jump to: 2017 | 2011 | 2010 | 2008
Number of items: 10.

2017

Lempereur, L. et al. (2017) Identification of candidate transmission-blocking antigen genes in Theileria annulata and related vector-borne apicomplexan parasites. BMC Genomics, 18(1), 438. (doi:10.1186/s12864-017-3788-1)

Kolte, S. W., Larcombe, S. D., Jadhao, S. G., Magar, S. P., Warthi, G., Kurkure, N. V., Glass, E. J. and Shiels, B. R. (2017) PCR diagnosis of tick-borne pathogens in Maharashtra state, India indicates fitness cost associated with carrier infections is greater for crossbreed than native cattle breeds. PLoS ONE, 12(3), e0174595. (doi:10.1371/journal.pone.0174595) (PMID:28358861) (PMCID:PMC5373575)

2011

Herborn, K. A., Coffey, J., Larcombe, S. D., Alexander, L. and Arnold, K. E. (2011) Oxidative profile varies with personality in European greenfinches. Journal of Experimental Biology, 214(10), pp. 1732-1739. (doi:10.1242/jeb.051383)

2010

Arnold, K.E., Ramsay, S.L., Henderson, L. and Larcombe, S.D. (2010) Seasonal variation in diet quality: antioxidants, invertebrates and blue tits Cyanistes caeruleus. Biological Journal of the Linnean Society, 99(4), pp. 708-717. (doi:10.1111/j.1095-8312.2010.01377.x)

Larcombe, S.D., Coffey, J.S., Bann, D., Alexander, L. and Arnold, K.E. (2010) Impacts of dietary antioxidants and flight training on post-exercise oxidative damage in adult parrots. Comparative Biochemistry and Physiology. Part B: Biochemistry and Molecular Biology, 155(1), pp. 49-53. (doi:10.1016/j.cbpb.2009.09.009)

Arnold, K. E., Larcombe, S. D., Ducaroir, L. and Alexander, L. (2010) Antioxidant status, flight performance and sexual signalling in wild-type parrots. Behavioral Ecology and Sociobiology, 64(11), pp. 1857-1866. (doi:10.1007/s00265-010-0997-x)

Larcombe, S.D., Coffey, J.S., Bann, D., Alexander, L. and Arnold, K.E. (2010) Impacts of dietary antioxidants and flight training on post-exercise oxidative damage in adult parrots. Comparative Biochemistry and Physiology. Part B: Biochemistry and Molecular Biology, 155(1), pp. 49-53. (doi:10.1016/j.cbpb.2009.09.009)

Larcombe, S. D., Mullen, W. , Alexander, L. and Arnold, K. E. (2010) Dietary antioxidants, lipid peroxidation and plumage colouration in nestling blue tits Cyanistes caeruleus. Naturwissenschaften, 97(10), pp. 903-913. (doi:10.1007/s00114-010-0708-5)

Mullen, W. , Larcombe, S., Arnold, K., Welchman, H. and Crozier, A. (2010) Use of accurate mass full scan mass spectrometry for the analysis of anthocyanins in berries and berry-fed tissues. Journal of Agricultural and Food Chemistry, 58(7), pp. 3910-3915. (doi:10.1021/jf902267v)

2008

Larcombe, S.D., Tregaskes, C.A., Coffey, J.S., Stevenson, A.E., Alexander, L. and Arnold, K.E. (2008) The effects of short-term antioxidant supplementation on oxidative stress and flight performance in adult budgerigars Melopsittacus undulatus. Journal of Experimental Biology, 211(17), pp. 2859-2864. (doi:10.1242/jeb.017970)

This list was generated on Sat Aug 19 17:44:48 2017 BST.
Jump to: Articles
Number of items: 10.

Articles

Lempereur, L. et al. (2017) Identification of candidate transmission-blocking antigen genes in Theileria annulata and related vector-borne apicomplexan parasites. BMC Genomics, 18(1), 438. (doi:10.1186/s12864-017-3788-1)

Kolte, S. W., Larcombe, S. D., Jadhao, S. G., Magar, S. P., Warthi, G., Kurkure, N. V., Glass, E. J. and Shiels, B. R. (2017) PCR diagnosis of tick-borne pathogens in Maharashtra state, India indicates fitness cost associated with carrier infections is greater for crossbreed than native cattle breeds. PLoS ONE, 12(3), e0174595. (doi:10.1371/journal.pone.0174595) (PMID:28358861) (PMCID:PMC5373575)

Herborn, K. A., Coffey, J., Larcombe, S. D., Alexander, L. and Arnold, K. E. (2011) Oxidative profile varies with personality in European greenfinches. Journal of Experimental Biology, 214(10), pp. 1732-1739. (doi:10.1242/jeb.051383)

Arnold, K.E., Ramsay, S.L., Henderson, L. and Larcombe, S.D. (2010) Seasonal variation in diet quality: antioxidants, invertebrates and blue tits Cyanistes caeruleus. Biological Journal of the Linnean Society, 99(4), pp. 708-717. (doi:10.1111/j.1095-8312.2010.01377.x)

Larcombe, S.D., Coffey, J.S., Bann, D., Alexander, L. and Arnold, K.E. (2010) Impacts of dietary antioxidants and flight training on post-exercise oxidative damage in adult parrots. Comparative Biochemistry and Physiology. Part B: Biochemistry and Molecular Biology, 155(1), pp. 49-53. (doi:10.1016/j.cbpb.2009.09.009)

Arnold, K. E., Larcombe, S. D., Ducaroir, L. and Alexander, L. (2010) Antioxidant status, flight performance and sexual signalling in wild-type parrots. Behavioral Ecology and Sociobiology, 64(11), pp. 1857-1866. (doi:10.1007/s00265-010-0997-x)

Larcombe, S.D., Coffey, J.S., Bann, D., Alexander, L. and Arnold, K.E. (2010) Impacts of dietary antioxidants and flight training on post-exercise oxidative damage in adult parrots. Comparative Biochemistry and Physiology. Part B: Biochemistry and Molecular Biology, 155(1), pp. 49-53. (doi:10.1016/j.cbpb.2009.09.009)

Larcombe, S. D., Mullen, W. , Alexander, L. and Arnold, K. E. (2010) Dietary antioxidants, lipid peroxidation and plumage colouration in nestling blue tits Cyanistes caeruleus. Naturwissenschaften, 97(10), pp. 903-913. (doi:10.1007/s00114-010-0708-5)

Mullen, W. , Larcombe, S., Arnold, K., Welchman, H. and Crozier, A. (2010) Use of accurate mass full scan mass spectrometry for the analysis of anthocyanins in berries and berry-fed tissues. Journal of Agricultural and Food Chemistry, 58(7), pp. 3910-3915. (doi:10.1021/jf902267v)

Larcombe, S.D., Tregaskes, C.A., Coffey, J.S., Stevenson, A.E., Alexander, L. and Arnold, K.E. (2008) The effects of short-term antioxidant supplementation on oxidative stress and flight performance in adult budgerigars Melopsittacus undulatus. Journal of Experimental Biology, 211(17), pp. 2859-2864. (doi:10.1242/jeb.017970)

This list was generated on Sat Aug 19 17:44:48 2017 BST.