Dr Paddy Brock

  • Research Associate (Institute of Biodiversity Animal Health and Comparative Medicine)

telephone: 01413305717
email: Paddy.Brock@glasgow.ac.uk

Research interests

Research interests

I'm interested in quantitative approaches to understanding disease transmission, particularly in multi-host systems that involve wildlife. Currently, I work on an ESEI-funded project on the zoonotic malaria Plasmodium knowlesi, for which we are integrating analysis tools from ecology and epidemiology.

Previously, I used statistical and mechanistic models to assess transmission-blocking interventions for malaria, looking at how they are influenced by parasite density. I also investigated the dynamics of co-infection between HIV and HPV (human papillomavirus), and the implications of these for the effectiveness of public health interventions.

I maintain an interest in the study of immunity in an ecological context, as an example of how individual-level variation can influence population-level disease risk. I explored this, and related issues, in the Galapagos sea lion (below) during my PhD, and continue to collaborate with the Galapagos National Park on ways to incorporate research findings into conservation management programmes.


Wider interests

I’m enthusiastic about science communication as a way to engage non-specialists and young people, and to help scientists develop interdisciplinary dialogue. I enjoy talking to school groups, and was a winning participant in the Wellcome Trust-funded school outreach programme I’m a Scientist, Get me out of here

I’m currently participating in a science-art project Silent Signal, which is funded by a Wellcome Trust Large Arts Award (more information).

I’m also keen on the development of software tools for engagement: on World Health Day (below) we built an interactive app in Shiny to communicate the results of mathematical models to NGOs and MPs at the Houses of Parliament.

Publications

List by: Type | Date

Jump to: 2017 | 2016 | 2015 | 2014 | 2013 | 2009
Number of items: 12.

2017

Churcher, T. S. et al. (2017) Probability of transmission of malaria from mosquito to human is regulated by mosquito parasite density in naïve and vaccinated hosts. PLoS Pathogens, 13(1), e1006108. (doi:10.1371/journal.ppat.1006108)

2016

Brock, P. M., Fornace, K. M., Parmiter, M., Cox, J., Drakeley, C. J., Ferguson, H. M., and Kao, R. R. (2016) Plasmodium knowlesi transmission: integrating quantitative approaches from epidemiology and ecology to understand malaria as a zoonosis. Parasitology, 143(04), pp. 389-400. (doi:10.1017/S0031182015001821) (PMID:26817785)

Fornace, K.M., Abidin, T.R., Alexander, N., Brock, P., Grigg, M.J., William, T., Menon, J., Drakeley, C.J., and Cox, J. (2016) Association between landscape factors and spatial patterns of plasmodium knowlesi Infections in Sabah, Malaysia. Emerging Infectious Diseases, 22(2), pp. 201-208. (doi:10.3201/eid2202.150656) (PMID:26812373) (PMCID:PMC4734530)

2015

Brock, P. M., Goodman, S. J., Hall, A. J., Cruz, M., and Acevedo-Whitehouse, K. (2015) Context-dependent associations between heterozygosity and immune variation in a wild carnivore. BMC Evolutionary Biology, 15(1), 242. (doi:10.1186/s12862-015-0519-6)

Owen, B. N., Brock, P. M., Butler, A. R., Pickles, M., Brisson, M., Baggaley, R. F., and Boily, M.-C. (2015) Prevalence and frequency of heterosexual anal intercourse among young people: a systematic review and meta-analysis. AIDS and Behavior, 19(7), pp. 1338-1360. (doi:10.1007/s10461-015-0997-y) (PMID:25618257)

Baragaña, B. et al. (2015) A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature, 522(7556), pp. 315-320. (doi:10.1038/nature14451)

Vera-Massieu, C., Brock, P. M., Godinez-Reyes, C., and Acevedo-Whitehouse, K. (2015) Activation of an inflammatory response is context-dependent during early development of the California sea lion. Royal Society Open Science, 2(4), 150108. (doi:10.1098/rsos.150108)

Upton, L.M., Brock, P.M., Churcher, T.S., Ghani, A.C., Gething, P.W., Delves, M.J., Sala, K.A., Leroy, D., Sinden, R.E., and Blagborough, A.M. (2015) Lead clinical and pre-clinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations. Antimicrobial Agents and Chemotherapy, 59(1), pp. 490-497. (doi:10.1128/AAC.03942-14) (PMID:25385107) (PMCID:PMC4291391)

2014

Brock, P. M., Murdock, C. C., and Martin, L. B. (2014) The history of ecoimmunology and its integration with disease ecology. Integrative and Comparative Biology, 54(3), pp. 353-362. (doi:10.1093/icb/icu046)

2013

Brock, P. M., Hall, A. J., Goodman, S. J., Cruz, M., and Acevedo-Whitehouse, K. (2013) Applying the tools of ecological immunology to conservation: a test case in the Galapagos sea lion. Animal Conservation, 16(1), pp. 19-31. (doi:10.1111/j.1469-1795.2012.00567.x)

Brock, P. M., Hall, A. J., Goodman, S. J., Cruz, M., and Acevedo-Whitehouse, K. (2013) Immune activity, body condition and human-associated environmental impacts in a wild marine mammal. PLoS ONE, 8(6), e67132. (doi:10.1371/journal.pone.0067132)

2009

Brock, P. M., Döring, H., and Bidartondo, M. I. (2009) How to know unknown fungi: the role of a herbarium. New Phytologist, 181(3), pp. 719-724. (doi:10.1111/j.1469-8137.2008.02703.x)

This list was generated on Sat Mar 25 01:46:04 2017 GMT.
Jump to: Articles
Number of items: 12.

Articles

Churcher, T. S. et al. (2017) Probability of transmission of malaria from mosquito to human is regulated by mosquito parasite density in naïve and vaccinated hosts. PLoS Pathogens, 13(1), e1006108. (doi:10.1371/journal.ppat.1006108)

Brock, P. M., Fornace, K. M., Parmiter, M., Cox, J., Drakeley, C. J., Ferguson, H. M., and Kao, R. R. (2016) Plasmodium knowlesi transmission: integrating quantitative approaches from epidemiology and ecology to understand malaria as a zoonosis. Parasitology, 143(04), pp. 389-400. (doi:10.1017/S0031182015001821) (PMID:26817785)

Fornace, K.M., Abidin, T.R., Alexander, N., Brock, P., Grigg, M.J., William, T., Menon, J., Drakeley, C.J., and Cox, J. (2016) Association between landscape factors and spatial patterns of plasmodium knowlesi Infections in Sabah, Malaysia. Emerging Infectious Diseases, 22(2), pp. 201-208. (doi:10.3201/eid2202.150656) (PMID:26812373) (PMCID:PMC4734530)

Brock, P. M., Goodman, S. J., Hall, A. J., Cruz, M., and Acevedo-Whitehouse, K. (2015) Context-dependent associations between heterozygosity and immune variation in a wild carnivore. BMC Evolutionary Biology, 15(1), 242. (doi:10.1186/s12862-015-0519-6)

Owen, B. N., Brock, P. M., Butler, A. R., Pickles, M., Brisson, M., Baggaley, R. F., and Boily, M.-C. (2015) Prevalence and frequency of heterosexual anal intercourse among young people: a systematic review and meta-analysis. AIDS and Behavior, 19(7), pp. 1338-1360. (doi:10.1007/s10461-015-0997-y) (PMID:25618257)

Baragaña, B. et al. (2015) A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature, 522(7556), pp. 315-320. (doi:10.1038/nature14451)

Vera-Massieu, C., Brock, P. M., Godinez-Reyes, C., and Acevedo-Whitehouse, K. (2015) Activation of an inflammatory response is context-dependent during early development of the California sea lion. Royal Society Open Science, 2(4), 150108. (doi:10.1098/rsos.150108)

Upton, L.M., Brock, P.M., Churcher, T.S., Ghani, A.C., Gething, P.W., Delves, M.J., Sala, K.A., Leroy, D., Sinden, R.E., and Blagborough, A.M. (2015) Lead clinical and pre-clinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations. Antimicrobial Agents and Chemotherapy, 59(1), pp. 490-497. (doi:10.1128/AAC.03942-14) (PMID:25385107) (PMCID:PMC4291391)

Brock, P. M., Murdock, C. C., and Martin, L. B. (2014) The history of ecoimmunology and its integration with disease ecology. Integrative and Comparative Biology, 54(3), pp. 353-362. (doi:10.1093/icb/icu046)

Brock, P. M., Hall, A. J., Goodman, S. J., Cruz, M., and Acevedo-Whitehouse, K. (2013) Applying the tools of ecological immunology to conservation: a test case in the Galapagos sea lion. Animal Conservation, 16(1), pp. 19-31. (doi:10.1111/j.1469-1795.2012.00567.x)

Brock, P. M., Hall, A. J., Goodman, S. J., Cruz, M., and Acevedo-Whitehouse, K. (2013) Immune activity, body condition and human-associated environmental impacts in a wild marine mammal. PLoS ONE, 8(6), e67132. (doi:10.1371/journal.pone.0067132)

Brock, P. M., Döring, H., and Bidartondo, M. I. (2009) How to know unknown fungi: the role of a herbarium. New Phytologist, 181(3), pp. 719-724. (doi:10.1111/j.1469-8137.2008.02703.x)

This list was generated on Sat Mar 25 01:46:04 2017 GMT.