Professor Colin Selman

  • Professor of Biogerontology (Institute of Biodiversity Animal Health and Comparative Medicine)
  • Associate (School of Life Sciences)
  • Associate Academic (Biochemistry & Cell Biology)

telephone: 01413306077
email: Colin.Selman@glasgow.ac.uk

Research interests

Key words: Ageing, dietary restriction, insulin/IGF-1 signalling, mTOR signalling, mitochondria, oxidative stress

My research interests focus on understanding the mechanisms underlying the ageing process, primarily in mammals.

Research Interests - Further Information

Google Scholar - Publications Profile

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Thiol Modification and Redox Signalling
    Medical Research Council
    2016 - 2017
     
  • Can studying the mechanism of action of the parasitic worm-derived immunomodulator ES-62, inform on how to slow ageing and improve healthspan?
    Biotechnology and Biological Sciences Research Council
    2016 - 2019
     
  • Androgens: unlocking the key drivers of male health and wellbeing
    Medical Research Council
    2016 - 2021
     
  • RSE International Exchange Programme: IEP India
    Royal Society of Edinburgh
    2013 - 2013
     
  • METAPHEN: The Ecology of Metabolic Phenotypes: From Cells to Populations
    European Research Council
    2013 - 2018
     
  • Effects of Inorganic Nitrite on cardiac and skeletal muscle: Physiology, Pharmacology and Therapeutic Potential
    Medical Research Council
    2013 - 2016
     
  • Dissecting the mechanisms underlying lifespan extension in insulin signalling mutant mice
    Biotechnology and Biological Sciences Research Council
    2013 - 2013
     

Additional information

Editorial Board

  • 2016 - 2016: Guest Editor: Mammalian Genome Special Issue on Ageing
  • 2015 - ongoing: Editorial Board Member: Scientific Reports
  • 2015 - 2015: Guest Editor: Experimental Gerontology Special Issue Aging in the Wild: Insights from Free-Living and Non-Model organisms

Grant Advisory Board

  • 2014 - ongoing: BBSRC Ageing Mouse Resource Working Group
  • 2011 - ongoing: American Federation for Aging Research - Member, National Scientific Advisory Council

Invited International Presentations

  • 2016: Potsdam, Germany - Rehbrücke Colloquium, German Institute of Human Nutrition
  • 2016: Grasmere, UK - The Rank Prize Funds. Mini Symposium- Dietary Restriction and Ageing. Joint Organiser
  • 2015: London, UK - Institute of Healthy Ageing, UCL
  • 2014: Grasmere, UK - The Rank Prize Funds. Mini Symposium- Oxidative stress, does it play a role in life histories and ageing. Joint Organiser
  • 2014: Glasgow, Scotland, UK - Third Triennial Conference of the Royal College of Physicians and Surgeons of Glasgow
  • 2013: Newcastle-upon-Tyne, England, UK - The Nutrition Society Annual Meeting
  • 2013: Chicheley Hall, UK - Royal Society meeting on Nutrition and Ageing
  • 2012: Rotterdam, The Netherlands - Erasmus Lecture on Endocrinology, University of Rotterdam (Erasmus MC)
  • 2012: Helsinki, Finland - Scandinavian Physiological Society Annual Meeting
  • 2012: Birmingham, England, UK - BSRA Annual Scientific Meeting 2012
  • 2012: Glasgow, Scotland, UK - Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow
  • 2011: Novato, California, USA - Longevity Consortium Meeting, The Buck Institute
  • 2011: Glasgow, Scotland, UK - Keynote Speaker, Society for Experimental Biology
  • 2011: Birmingham, England, UK - Society of Endocrinology
  • 2011: Wageningen, The Netherlands - Cost Action FA0602: 'Bioactive Food Components, Mitochondrial Function and Health (Mitofood)'
  • 2011: Amsterdam, The Netherlands - CBG/CGC Meeting, The molecular basis and modification of the aging process
  • 2010: London, England, UK - Keynote Speaker, 3rd Young Investigator's Workshop of 'LifeSpan' and 'LINKAGE'
  • 2010: Newcastle-upon-Tyne, England, UK - BSRA Annual Scientific Meeting 2010
  • 2010: Aberdeen, Scotland, UK - Seminar, Bone and Musculoskeletal Research, University of Aberdeen
  • 2010: Aberdeen, Scotland, UK - Rowett Research Institute, University of Aberdeen
  • 2010: Israel - Joint Israel/UK Workshop on Pathways in Ageing and Premature Ageing
  • 2010: Newcastle-upon-Tyne, England, UK - Institute of Ageing, University of Newcastle
  • 2010: Edinburgh, Scotland, UK - Centre for Cardiovascular Science, University of Edinburgh
  • 2009: Montecatini, Italy - Plenary Session: 6th European Nutrigenomics Organisation
  • 2009: Vienna, Austria - Konrad Lorenz Institute for Ethology, University of Vienna
  • 2009: Durham, England, UK - Department of Biological Sciences, University of Durham
  • 2009: Dundee, Scotland, UK - Department of Neuroscience, University of Dundee
  • 2008: Edinburgh, Scotland, UK - Institute of Evolutionary Biology, University of Edinburgh
  • 2008: Schroeken, Austria - O2k-Course on High-Resolution Respirometry

Professional Learned Society

  • 2016 - 2020: EU COST ACTION Mitochondrial mapping - Evolution - Age - Gender - Lifestyle - Environment (MITOEAGLE) Member
  • 2014 - 2018: EU COST ACTION BM1402 MOUSE AGE Management Committee Member
  • 2010 - 2013: British Society for Research on Ageing - Executive Committee Member
  • 2001 - ongoing: American Physiology Society - Member

Publications

List by: Type | Date

Jump to: 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999
Number of items: 71.

2016

Panagiotou, N., Davies, R. W., Selman, C., and Shiels, P. R. (2016) Microvesicles as vehicles for tissue regeneration: Changing of the guards. Current Pathobiology Reports, (doi:10.1007/s40139-016-0115-5) (Early Online Publication)

Salin, K., Auer, S. K., Anderson, G. J., Selman, C., and Metcalfe, N. B. (2016) Inadequate food intake at high temperatures is related to depressed mitochondrial respiratory capacity. Journal of Experimental Biology, (doi:10.1242/jeb.133025) (PMID:26944497) (Early Online Publication)

Selman, C., Sinclair, A., Pedroni, S. M.A., Irvine, E. E., Michie, A. M., and Withers, D. J. (2016) Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice. Oncotarget, 7, 21. (doi:10.18632/oncotarget.8729) (PMID:27083004)

2015

Speakman, J. R. et al. (2015) Oxidative stress and life histories: unresolved issues and current needs. Ecology and Evolution, 5(24), pp. 5745-5757. (doi:10.1002/ece3.1790)

Christensen, L. L., Selman, C., Blount, J. D., Pilkington, J. G., Watt, K. A., Pemberton, J. M., Reid, J. M., and Nussey, D. H. (2015) Plasma markers of oxidative stress are uncorrelated in a wild mammal. Ecology and Evolution, 5(21), pp. 5096-5108. (doi:10.1002/ece3.1771)

Fletcher, Q., and Selman, C. (2015) Aging in the wild: insights from free-living and non-model organisms. Experimental Gerontology, 71, pp. 1-3. (doi:10.1016/j.exger.2015.09.015) (PMID:26403678)

Salin, K., Auer, S. k., Rudolf, A. M., Anderson, G. J., Cairns, A. G., Mullen, W., Hartley, R. C., Selman, C., and Metcalfe, N. B. (2015) Individuals with higher metabolic rates have lower levels of reactive oxygen species in vivo. Biology Letters, 11(9), 20150538. (doi:10.1098/rsbl.2015.0538) (PMID:26382073)

Sharples, A.P., Hughes, D.C., Deane, C.S., Saini, A., Selman, C., and Stewart, C.E. (2015) Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Aging Cell, 14(4), pp. 511-523. (doi:10.1111/acel.12342) (PMID:25866088) (PMCID:PMC4531066)

Salin, K., Auer, S. K., Rey, B., Selman, C., and Metcalfe, N. B. (2015) Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance. Proceedings of the Royal Society of London Series B: Biological Sciences, 282(1812), 20151028. (doi:10.1098/rspb.2015.1028) (PMID:26203001)

2014

Jové, M., Naudí, A., Ramírez-Núñez, O., Portero-Otín, M., Selman, C., Withers, D. J., and Pamplona, R. (2014) Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice. Aging Cell, 13(5), pp. 828-837. (doi:10.1111/acel.12241)

Page, M. M., Sinclair, A., Robb, E. L., Stuart, J. A., Withers, D. J., and Selman, C. (2014) Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress. Aging Cell, 13(5), pp. 962-964. (doi:10.1111/acel.12255) (PMID:25059507) (PMCID:PMC4331740)

Mulvey, L., Sinclair, A., and Selman, C. (2014) Lifespan modulation in mice and the confounding effects of genetic background. Journal of Genetics and Genomics, 41(9), pp. 497-503. (doi:10.1016/j.jgg.2014.06.002) (PMID:25269675) (PMCID:PMC4257991)

Piper, M. D.W., Selman, C., Speakman, J. R., and Partridge, L. (2014) Using doubly-labeled water to measure energy expenditure in an important small Ectotherm Drosophila melanogaster. Journal of Genetics and Genomics, 41(9), pp. 505-512. (doi:10.1016/j.jgg.2014.07.004)

Selman, C. (2014) Dietary restriction and the pursuit of effective mimetics. Proceedings of the Nutrition Society, 73(02), pp. 260-270. (doi:10.1017/S0029665113003832) (PMID:4411076)

2013

Selman, C., Nussey, D.H., and Monaghan, P. (2013) Ageing: it’s a dog’s life. Current Biology, 23(10), R451-R453. (doi:10.1016/j.cub.2013.04.005)

Fletcher, Q.E., Selman, C., Boutin, S., McAdam, A.G., Woods, S.B., Seo, A.Y., Leeuwenburgh, C., Speakman, J.R., and Humphries, M.M. (2013) Oxidative damage increases with reproductive energy expenditure and is reduced by food supplementation. Evolution, 67(5), pp. 1527-1536. (doi:10.1111/evo.12014)

Archer, C.R., Sakaluk, S.K., Selman, C., Royle, N.J., and Hunt, J. (2013) Oxidative stress and the evolution of sex differences in life span and ageing in the decorated cricket, gryllodes sigillatus. Evolution, 67(3), pp. 620-634. (doi:10.1111/j.1558-5646.2012.01805.x)

2012

Selman, C., Blount, J.D., Nussey, D.H., and Speakman, J.R. (2012) Oxidative damage, ageing, and life-history evolution: where now? Trends in Ecology and Evolution, 27(10), pp. 570-577. (doi:10.1016/j.tree.2012.06.006)

Lee, J.S. et al. (2012) Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging. Mechanisms of Ageing and Development, 133(7), pp. 467-478. (doi:10.1016/j.mad.2012.05.006)

Wijeyesekera, A., Selman, C., Barton, R.H., Holmes, E., Nicholson, J.K., and Withers, D.J. (2012) Metabotyping of long-lived mice using1H NMR spectroscopy. Journal of Proteome Research, 11(4), pp. 2224-2235. (doi:10.1021/pr2010154)

Page, M.M., Withers, D.J., and Selman, C. (2012) Longevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage. Age, 29, (doi:10.1007/s11357-012-9395-9)

Selman, C., and Partridge, L. (2012) A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice. Cell Cycle, 11(1), pp. 13-18. (doi:10.4161/cc.11.1.18736)

Hempenstall, S., Page, M.M., Wallen, K.R., and Selman, C. (2012) Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice. Mechanisms of Ageing and Development, 133(1), pp. 37-45. (doi:10.1016/j.mad.2011.12.002)

Selman, C., and Hempenstall, S. (2012) Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice. Longevity and Healthspan, 1(2), (doi:10.1186/2046-2395-1-2)

2011

Wyse, C.A., Selman, C., Page, M.M., Coogan, A.N., and Hazlerigg, D.G. (2011) Circadian desynchrony and metabolic dysfunction; did light pollution make us fat? Medical Hypotheses, 77(6), pp. 1139-1144. (doi:10.1016/j.mehy.2011.09.023)

Speakman, J.R., and Selman, C. (2011) The free-radical damage theory: accumulating evidence against a simple link of oxidative stress to ageing and lifespan. BioEssays, 33(4), pp. 255-259. (doi:10.1002/bies.201000132)

Selman, C., and Withers, D.J. (2011) Mammalian models of extended healthy lifespan. Philosophical Transactions of the Royal Society B: Biological Sciences, 366(1561), pp. 99-107. (doi:10.1098/rstb.2010.0243)

Selman, C., Partridge, L., and Withers, D.J. (2011) Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1. PLoS ONE, 6(1), e16144. (doi:10.1371/journal.pone.0016144)

2010

Wyse, C.A., Coogan, A.N., Selman, C., Hazlerigg, D.G., and Speakman, J.R. (2010) Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited. Biology Letters, 6(5), pp. 696-698. (doi:10.1098/rsbl.2010.0152)

Banks, R., Speakman, J.R., and Selman, C. (2010) Vitamin E supplementation and mammalian lifespan. Molecular Nutrition and Food Research, 54(5), pp. 719-725. (doi:10.1002/mnfr.200900382)

Hempenstall, S., Picchio, L., Mitchell, S.E., Speakman, J.R., and Selman, C. (2010) The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 mice. Mechanisms of Ageing and Development, 131(2), pp. 111-118. (doi:10.1016/j.mad.2009.12.008)

2009

Al-Qassab, H. et al. (2009) Dominant role of the p110β isoform of PI3K over p110α in energy homeostasis regulation by POMC and AgRP neurons. Cell Metabolism, 10(5), pp. 343-354. (doi:10.1016/j.cmet.2009.09.008)

Selman, C. et al. (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science, 326(5949), pp. 140-144. (doi:10.1126/science.1177221)

Ruth Archer, C., Royle, N., South, S., Selman, C., and Hunt, J. (2009) Nutritional geometry provides food for thought. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 64A(9), pp. 956-959. (doi:10.1093/gerona/glp069)

Cantley, J. et al. (2009) Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice. Journal of Clinical Investigation, 119(1), pp. 125-135. (doi:10.1172/JCI26934)

2008

Selman, C., McLaren, J.S., Collins, A.R., Duthie, G.G., and Speakman, J.R. (2008) The impact of experimentally elevated energy expenditure on oxidative stress and lifespan in the short-tailed field vole microtus agrestis. Proceedings of the Royal Society of London Series B: Biological Sciences, 275(1645), pp. 1907-1916. (doi:10.1098/rspb.2008.0355)

Selman, C., Lingard, S., Gems, D., Partridge, L., and Withers, D.J. (2008) Comment on "brain IRS2 signaling coordinates life span and nutrient homeostasis". Science, 320(5879), 1012b-1012b. (doi:10.1126/science.1152366)

Selman, C. et al. (2008) Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB Journal, 22(3), pp. 807-818. (doi:10.1096/fj.07-9261com)

Selman, C., McLaren, J.S., Mayer, C., Duncan, J.S., Collins, A.R., Duthie, G.G., Redman, P., and Speakman, J.R. (2008) Lifelongα-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage. Rejuvenation Research, 11(1), pp. 83-96. (doi:10.1089/rej.2007.0586)

Piper, M.D.W., Selman, C., McElwee, J.J., and Partridge, L. (2008) Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice? Journal of Internal Medicine, 263(2), pp. 179-191. (doi:10.1111/j.1365-2796.2007.01906.x)

2007

Claret, M. et al. (2007) AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. Journal of Clinical Investigation, 117(8), pp. 2325-2336. (doi:10.1172/JCI31516)

Neganova, I. et al. (2007) Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse. Biology of Reproduction, 76(6), pp. 1045-1053. (doi:10.1095/biolreprod.106.059360)

Cantley, J., Choudhury, A.I., Asare-Anane, H., Selman, C., Lingard, S., Heffron, H., Herrera, P., Persaud, S.J., and Withers, D.J. (2007) Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice. Diabetologia, 50(6), pp. 1248-1256. (doi:10.1007/s00125-007-0637-9)

McElwee, J.J. et al. (2007) Evolutionary conservation of regulated longevity assurance mechanisms. Genome Biology, 8(7), R132. (doi:10.1186/gb-2007-8-7-r132)

2006

Selman, C. et al. (2006) Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice. Physiological Genomics, 27(3), pp. 187-200. (doi:10.1152/physiolgenomics.00084.2006)

Selman, C., McLaren, J.S., Meyer, C., Duncan, J.S., Redman, P., Collins, A.R., Duthie, G.G., and Speakman, J.R. (2006) Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes. Mechanisms of Ageing and Development, 127(12), pp. 897-904. (doi:10.1016/j.mad.2006.09.008)

2005

Humphries, M.M., Boutin, S., Thomas, D.W., Ryan, J.D., Selman, C., McAdam, A.G., Berteaux, D., and Speakman, J.R. (2005) Expenditure freeze: the metabolic response of small mammals to cold environments. Ecology Letters, 8(12), pp. 1326-1333. (doi:10.1111/j.1461-0248.2005.00839.x)

Choudhury, A.I. et al. (2005) The role of insulin receptor substrate 2 in hypothalamic and β cell function. Journal of Clinical Investigation, 115(4), pp. 940-950. (doi:10.1172/JCI24445)

Selman, C., and Evans, P.R. (2005) Alterations in tissue aerobic capacity may play a role in premigratory fattening in shorebirds. Biology Letters, 1(1), pp. 101-104. (doi:10.1098/rsbl.2004.0248)

Piper, M.D.W., Selman, C., McElwee, J.J., and Partridge, L. (2005) Models of insulin signalling and longevity. Drug Discovery Today: Disease Models, 2(4), pp. 249-256. (doi:10.1016/j.ddmod.2005.11.001)

Selman, C., Phillips, T., Staib, J.L., Duncan, J.S., Leeuwenburgh, C., and Speakman, J.R. (2005) Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition. Mechanisms of Ageing and Development, 126(6-7), pp. 783-793. (doi:10.1016/j.mad.2005.02.004)

2004

Judge, S., Jang, Y.M., Smith, A., Selman, C., Phillips, T., Speakman, J.R., Hagen, T., and Leeuwenburgh, C. (2004) Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart. AJP: Regulatory, Integrative and Comparative Physiology, 289(6), R1564-R1572. (doi:10.1152/ajpregu.00396.2005)

Jang, Y. M., Kendaiah, S., Drew, B., Phillips, T., Selman, C., Julian, D., and Leeuwenburgh, C. (2004) Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats. FEBS Letters, 577(3), pp. 483-490. (doi:10.1016/j.febslet.2004.10.053)

Wiersma, P., Selman, C., Speakman, J.R., and Verhulst, S. (2004) Birds sacrifice oxidative protection for reproduction. Proceedings of the Royal Society of London Series B: Biological Sciences, 271(Sup 5), S360-S363. (doi:10.1098/rsbl.2004.0171)

Itoh, M., Oh-ishi, S., Hatao, H., Leeuwenburgh, C., Selman, C., Ohno, H., Kizaki, T., Nakamura, H., and Matsuoka, T. (2004) Effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragm. AJP: Regulatory, Integrative and Comparative Physiology, 287(1), R33-R38. (doi:10.1152/ajpregu.00598.2003)

Gredilla, R., Phaneuf, S., Selman, C., Kendaiah, S., Leeunwenburgh, C., and Barja, G. (2004) Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria. Annals of the New York Academy of Sciences, 1019, pp. 333-342. (doi:10.1196/annals.1297.057)

Speakman, J.R., Talbot, D.A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D.M., Johnson, M.S., and Brand, M.D. (2004) Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. Aging Cell, 3(3), pp. 87-95. (doi:10.1111/j.1474-9728.2004.00097.x)

2003

Selman, C., Kendaiah, S., Gredilla, R., and Leeuwenburgh, C. (2003) Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levels. Experimental Gerontology, 38(8), pp. 897-903. (doi:10.1016/S0531-5565(03)00091-3)

Speakman, J.R., and Selman, C. (2003) Physical activity and resting metabolic rate. Proceedings of the Nutrition Society, 62(3), pp. 621-634. (doi:10.1079/PNS2003282)

Selman, C., Gredilla, R., Phaneuf, S., Kendaiah, S., Barja, G., and Leeuwenburgh, C. (2003) Short-term caloric restriction and regulatory proteins of apoptosis in heart, skeletal muscle and kidney of Fischer 344 rats. Biogerontology, 4(3), pp. 141-147. (doi:10.1023/A:1024149923693)

Selman, C., and Leeuwenburgh, C. (2003) The role of Id2 and apoptosis during skeletal muscle remodeling. AJP: Regulatory, Integrative and Comparative Physiology, 284(2), R538-R539. (doi:10.​1152/​ajpregu.​00679.​2002)

Drew, B., Phaneuf, S., Dirks, A., Selman, C., Gredilla, R., Lezza, A., Barja, G., and Leeuwenburgh, C. (2003) Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart. AJP: Regulatory, Integrative and Comparative Physiology, 284(2), R474-80. (doi:10.​1152/​ajpregu.​00455.​2002)

2002

Selman, C., Grune, T., Stolzing, A., Jakstadt, M., McLaren, J.S., and Speakman, J.R. (2002) The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, microtus agrestis. Free Radical Biology and Medicine, 33(2), pp. 259-265. (doi:10.1016/S0891-5849(02)00874-2)

Selman, C., McLaren, J.S., Collins, A.R., and Speakman, J.R. (2002) Voluntary exercise has only limited effects on activity of antioxidant enzymes and does not cause oxidative damage in a small mammal. Journal of Nutrition, 132(6 Supp), 1784S-1786S.

Speakman, J.R., Selman, C., McLaren, J.S., and Harper, E.J. (2002) Living fast, dying when? The link between aging and energetics. Journal of Nutrition, 132(6), 1583S-1597S.

Selman, C., McLaren, J.S., Collins, A.R., Duthie, G.G., and Speakman, J.R. (2002) Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel running. Archives of Biochemistry and Biophysics, 401(2), pp. 255-261. (doi:10.1016/S0003-9861(02)00050-4)

2001

Selman, C., Korhonen, T.K., Bünger, L., Hill, W.G., and Speakman, J.R. (2001) Thermoregulatory responses of two mouse Mus musculus strains selectively bred for high and low food intake. Journal of Comparative Physiology B: Biochemical, Systemic and Environmental Physiology, 171(8), pp. 661-668.

Selman, C., Lumsden, S., Bünger, L., Hill, W.G., and Speakman, J.R. (2001) Resting metabolic rate and morphology in mice (Mus musculus) selected for high and low food intake. Journal of Experimental Biology, 204(4), pp. 777-784.

2000

Lindsay, S., Ansell, J., Selman, C., Cox, V., Hamilton, K., and Walraven, G. (2000) Effect of pregnancy on exposure to malaria mosquitoes. Lancet, 355(9219), p. 1972. (doi:10.1016/S0140-6736(00)02334-5)

Selman, C., McLaren, J.S., Himanka, M.J., and Speakman, J.R. (2000) Effect of long-term cold exposure on antioxidant enzyme activities in a small mammal. Free Radical Biology and Medicine, 28(8), pp. 1279-1285. (doi:10.1016/S0891-5849(00)00263-X)

1999

Redman, P., Selman, C., and Speakman, J.R. (1999) Male short-tailed field voles (Microtus agrestis) build better insulated nests than females. Journal of Comparative Physiology B: Biochemical, Systemic and Environmental Physiology, 169(8), pp. 581-587.

This list was generated on Mon Sep 26 07:16:48 2016 BST.
Jump to: Articles
Number of items: 71.

Articles

Panagiotou, N., Davies, R. W., Selman, C., and Shiels, P. R. (2016) Microvesicles as vehicles for tissue regeneration: Changing of the guards. Current Pathobiology Reports, (doi:10.1007/s40139-016-0115-5) (Early Online Publication)

Salin, K., Auer, S. K., Anderson, G. J., Selman, C., and Metcalfe, N. B. (2016) Inadequate food intake at high temperatures is related to depressed mitochondrial respiratory capacity. Journal of Experimental Biology, (doi:10.1242/jeb.133025) (PMID:26944497) (Early Online Publication)

Selman, C., Sinclair, A., Pedroni, S. M.A., Irvine, E. E., Michie, A. M., and Withers, D. J. (2016) Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice. Oncotarget, 7, 21. (doi:10.18632/oncotarget.8729) (PMID:27083004)

Speakman, J. R. et al. (2015) Oxidative stress and life histories: unresolved issues and current needs. Ecology and Evolution, 5(24), pp. 5745-5757. (doi:10.1002/ece3.1790)

Christensen, L. L., Selman, C., Blount, J. D., Pilkington, J. G., Watt, K. A., Pemberton, J. M., Reid, J. M., and Nussey, D. H. (2015) Plasma markers of oxidative stress are uncorrelated in a wild mammal. Ecology and Evolution, 5(21), pp. 5096-5108. (doi:10.1002/ece3.1771)

Fletcher, Q., and Selman, C. (2015) Aging in the wild: insights from free-living and non-model organisms. Experimental Gerontology, 71, pp. 1-3. (doi:10.1016/j.exger.2015.09.015) (PMID:26403678)

Salin, K., Auer, S. k., Rudolf, A. M., Anderson, G. J., Cairns, A. G., Mullen, W., Hartley, R. C., Selman, C., and Metcalfe, N. B. (2015) Individuals with higher metabolic rates have lower levels of reactive oxygen species in vivo. Biology Letters, 11(9), 20150538. (doi:10.1098/rsbl.2015.0538) (PMID:26382073)

Sharples, A.P., Hughes, D.C., Deane, C.S., Saini, A., Selman, C., and Stewart, C.E. (2015) Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Aging Cell, 14(4), pp. 511-523. (doi:10.1111/acel.12342) (PMID:25866088) (PMCID:PMC4531066)

Salin, K., Auer, S. K., Rey, B., Selman, C., and Metcalfe, N. B. (2015) Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance. Proceedings of the Royal Society of London Series B: Biological Sciences, 282(1812), 20151028. (doi:10.1098/rspb.2015.1028) (PMID:26203001)

Jové, M., Naudí, A., Ramírez-Núñez, O., Portero-Otín, M., Selman, C., Withers, D. J., and Pamplona, R. (2014) Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice. Aging Cell, 13(5), pp. 828-837. (doi:10.1111/acel.12241)

Page, M. M., Sinclair, A., Robb, E. L., Stuart, J. A., Withers, D. J., and Selman, C. (2014) Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress. Aging Cell, 13(5), pp. 962-964. (doi:10.1111/acel.12255) (PMID:25059507) (PMCID:PMC4331740)

Mulvey, L., Sinclair, A., and Selman, C. (2014) Lifespan modulation in mice and the confounding effects of genetic background. Journal of Genetics and Genomics, 41(9), pp. 497-503. (doi:10.1016/j.jgg.2014.06.002) (PMID:25269675) (PMCID:PMC4257991)

Piper, M. D.W., Selman, C., Speakman, J. R., and Partridge, L. (2014) Using doubly-labeled water to measure energy expenditure in an important small Ectotherm Drosophila melanogaster. Journal of Genetics and Genomics, 41(9), pp. 505-512. (doi:10.1016/j.jgg.2014.07.004)

Selman, C. (2014) Dietary restriction and the pursuit of effective mimetics. Proceedings of the Nutrition Society, 73(02), pp. 260-270. (doi:10.1017/S0029665113003832) (PMID:4411076)

Selman, C., Nussey, D.H., and Monaghan, P. (2013) Ageing: it’s a dog’s life. Current Biology, 23(10), R451-R453. (doi:10.1016/j.cub.2013.04.005)

Fletcher, Q.E., Selman, C., Boutin, S., McAdam, A.G., Woods, S.B., Seo, A.Y., Leeuwenburgh, C., Speakman, J.R., and Humphries, M.M. (2013) Oxidative damage increases with reproductive energy expenditure and is reduced by food supplementation. Evolution, 67(5), pp. 1527-1536. (doi:10.1111/evo.12014)

Archer, C.R., Sakaluk, S.K., Selman, C., Royle, N.J., and Hunt, J. (2013) Oxidative stress and the evolution of sex differences in life span and ageing in the decorated cricket, gryllodes sigillatus. Evolution, 67(3), pp. 620-634. (doi:10.1111/j.1558-5646.2012.01805.x)

Selman, C., Blount, J.D., Nussey, D.H., and Speakman, J.R. (2012) Oxidative damage, ageing, and life-history evolution: where now? Trends in Ecology and Evolution, 27(10), pp. 570-577. (doi:10.1016/j.tree.2012.06.006)

Lee, J.S. et al. (2012) Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging. Mechanisms of Ageing and Development, 133(7), pp. 467-478. (doi:10.1016/j.mad.2012.05.006)

Wijeyesekera, A., Selman, C., Barton, R.H., Holmes, E., Nicholson, J.K., and Withers, D.J. (2012) Metabotyping of long-lived mice using1H NMR spectroscopy. Journal of Proteome Research, 11(4), pp. 2224-2235. (doi:10.1021/pr2010154)

Page, M.M., Withers, D.J., and Selman, C. (2012) Longevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage. Age, 29, (doi:10.1007/s11357-012-9395-9)

Selman, C., and Partridge, L. (2012) A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice. Cell Cycle, 11(1), pp. 13-18. (doi:10.4161/cc.11.1.18736)

Hempenstall, S., Page, M.M., Wallen, K.R., and Selman, C. (2012) Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice. Mechanisms of Ageing and Development, 133(1), pp. 37-45. (doi:10.1016/j.mad.2011.12.002)

Selman, C., and Hempenstall, S. (2012) Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice. Longevity and Healthspan, 1(2), (doi:10.1186/2046-2395-1-2)

Wyse, C.A., Selman, C., Page, M.M., Coogan, A.N., and Hazlerigg, D.G. (2011) Circadian desynchrony and metabolic dysfunction; did light pollution make us fat? Medical Hypotheses, 77(6), pp. 1139-1144. (doi:10.1016/j.mehy.2011.09.023)

Speakman, J.R., and Selman, C. (2011) The free-radical damage theory: accumulating evidence against a simple link of oxidative stress to ageing and lifespan. BioEssays, 33(4), pp. 255-259. (doi:10.1002/bies.201000132)

Selman, C., and Withers, D.J. (2011) Mammalian models of extended healthy lifespan. Philosophical Transactions of the Royal Society B: Biological Sciences, 366(1561), pp. 99-107. (doi:10.1098/rstb.2010.0243)

Selman, C., Partridge, L., and Withers, D.J. (2011) Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1. PLoS ONE, 6(1), e16144. (doi:10.1371/journal.pone.0016144)

Wyse, C.A., Coogan, A.N., Selman, C., Hazlerigg, D.G., and Speakman, J.R. (2010) Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited. Biology Letters, 6(5), pp. 696-698. (doi:10.1098/rsbl.2010.0152)

Banks, R., Speakman, J.R., and Selman, C. (2010) Vitamin E supplementation and mammalian lifespan. Molecular Nutrition and Food Research, 54(5), pp. 719-725. (doi:10.1002/mnfr.200900382)

Hempenstall, S., Picchio, L., Mitchell, S.E., Speakman, J.R., and Selman, C. (2010) The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 mice. Mechanisms of Ageing and Development, 131(2), pp. 111-118. (doi:10.1016/j.mad.2009.12.008)

Al-Qassab, H. et al. (2009) Dominant role of the p110β isoform of PI3K over p110α in energy homeostasis regulation by POMC and AgRP neurons. Cell Metabolism, 10(5), pp. 343-354. (doi:10.1016/j.cmet.2009.09.008)

Selman, C. et al. (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science, 326(5949), pp. 140-144. (doi:10.1126/science.1177221)

Ruth Archer, C., Royle, N., South, S., Selman, C., and Hunt, J. (2009) Nutritional geometry provides food for thought. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 64A(9), pp. 956-959. (doi:10.1093/gerona/glp069)

Cantley, J. et al. (2009) Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice. Journal of Clinical Investigation, 119(1), pp. 125-135. (doi:10.1172/JCI26934)

Selman, C., McLaren, J.S., Collins, A.R., Duthie, G.G., and Speakman, J.R. (2008) The impact of experimentally elevated energy expenditure on oxidative stress and lifespan in the short-tailed field vole microtus agrestis. Proceedings of the Royal Society of London Series B: Biological Sciences, 275(1645), pp. 1907-1916. (doi:10.1098/rspb.2008.0355)

Selman, C., Lingard, S., Gems, D., Partridge, L., and Withers, D.J. (2008) Comment on "brain IRS2 signaling coordinates life span and nutrient homeostasis". Science, 320(5879), 1012b-1012b. (doi:10.1126/science.1152366)

Selman, C. et al. (2008) Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB Journal, 22(3), pp. 807-818. (doi:10.1096/fj.07-9261com)

Selman, C., McLaren, J.S., Mayer, C., Duncan, J.S., Collins, A.R., Duthie, G.G., Redman, P., and Speakman, J.R. (2008) Lifelongα-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage. Rejuvenation Research, 11(1), pp. 83-96. (doi:10.1089/rej.2007.0586)

Piper, M.D.W., Selman, C., McElwee, J.J., and Partridge, L. (2008) Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice? Journal of Internal Medicine, 263(2), pp. 179-191. (doi:10.1111/j.1365-2796.2007.01906.x)

Claret, M. et al. (2007) AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. Journal of Clinical Investigation, 117(8), pp. 2325-2336. (doi:10.1172/JCI31516)

Neganova, I. et al. (2007) Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse. Biology of Reproduction, 76(6), pp. 1045-1053. (doi:10.1095/biolreprod.106.059360)

Cantley, J., Choudhury, A.I., Asare-Anane, H., Selman, C., Lingard, S., Heffron, H., Herrera, P., Persaud, S.J., and Withers, D.J. (2007) Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice. Diabetologia, 50(6), pp. 1248-1256. (doi:10.1007/s00125-007-0637-9)

McElwee, J.J. et al. (2007) Evolutionary conservation of regulated longevity assurance mechanisms. Genome Biology, 8(7), R132. (doi:10.1186/gb-2007-8-7-r132)

Selman, C. et al. (2006) Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice. Physiological Genomics, 27(3), pp. 187-200. (doi:10.1152/physiolgenomics.00084.2006)

Selman, C., McLaren, J.S., Meyer, C., Duncan, J.S., Redman, P., Collins, A.R., Duthie, G.G., and Speakman, J.R. (2006) Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes. Mechanisms of Ageing and Development, 127(12), pp. 897-904. (doi:10.1016/j.mad.2006.09.008)

Humphries, M.M., Boutin, S., Thomas, D.W., Ryan, J.D., Selman, C., McAdam, A.G., Berteaux, D., and Speakman, J.R. (2005) Expenditure freeze: the metabolic response of small mammals to cold environments. Ecology Letters, 8(12), pp. 1326-1333. (doi:10.1111/j.1461-0248.2005.00839.x)

Choudhury, A.I. et al. (2005) The role of insulin receptor substrate 2 in hypothalamic and β cell function. Journal of Clinical Investigation, 115(4), pp. 940-950. (doi:10.1172/JCI24445)

Selman, C., and Evans, P.R. (2005) Alterations in tissue aerobic capacity may play a role in premigratory fattening in shorebirds. Biology Letters, 1(1), pp. 101-104. (doi:10.1098/rsbl.2004.0248)

Piper, M.D.W., Selman, C., McElwee, J.J., and Partridge, L. (2005) Models of insulin signalling and longevity. Drug Discovery Today: Disease Models, 2(4), pp. 249-256. (doi:10.1016/j.ddmod.2005.11.001)

Selman, C., Phillips, T., Staib, J.L., Duncan, J.S., Leeuwenburgh, C., and Speakman, J.R. (2005) Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition. Mechanisms of Ageing and Development, 126(6-7), pp. 783-793. (doi:10.1016/j.mad.2005.02.004)

Judge, S., Jang, Y.M., Smith, A., Selman, C., Phillips, T., Speakman, J.R., Hagen, T., and Leeuwenburgh, C. (2004) Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart. AJP: Regulatory, Integrative and Comparative Physiology, 289(6), R1564-R1572. (doi:10.1152/ajpregu.00396.2005)

Jang, Y. M., Kendaiah, S., Drew, B., Phillips, T., Selman, C., Julian, D., and Leeuwenburgh, C. (2004) Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats. FEBS Letters, 577(3), pp. 483-490. (doi:10.1016/j.febslet.2004.10.053)

Wiersma, P., Selman, C., Speakman, J.R., and Verhulst, S. (2004) Birds sacrifice oxidative protection for reproduction. Proceedings of the Royal Society of London Series B: Biological Sciences, 271(Sup 5), S360-S363. (doi:10.1098/rsbl.2004.0171)

Itoh, M., Oh-ishi, S., Hatao, H., Leeuwenburgh, C., Selman, C., Ohno, H., Kizaki, T., Nakamura, H., and Matsuoka, T. (2004) Effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragm. AJP: Regulatory, Integrative and Comparative Physiology, 287(1), R33-R38. (doi:10.1152/ajpregu.00598.2003)

Gredilla, R., Phaneuf, S., Selman, C., Kendaiah, S., Leeunwenburgh, C., and Barja, G. (2004) Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria. Annals of the New York Academy of Sciences, 1019, pp. 333-342. (doi:10.1196/annals.1297.057)

Speakman, J.R., Talbot, D.A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D.M., Johnson, M.S., and Brand, M.D. (2004) Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. Aging Cell, 3(3), pp. 87-95. (doi:10.1111/j.1474-9728.2004.00097.x)

Selman, C., Kendaiah, S., Gredilla, R., and Leeuwenburgh, C. (2003) Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levels. Experimental Gerontology, 38(8), pp. 897-903. (doi:10.1016/S0531-5565(03)00091-3)

Speakman, J.R., and Selman, C. (2003) Physical activity and resting metabolic rate. Proceedings of the Nutrition Society, 62(3), pp. 621-634. (doi:10.1079/PNS2003282)

Selman, C., Gredilla, R., Phaneuf, S., Kendaiah, S., Barja, G., and Leeuwenburgh, C. (2003) Short-term caloric restriction and regulatory proteins of apoptosis in heart, skeletal muscle and kidney of Fischer 344 rats. Biogerontology, 4(3), pp. 141-147. (doi:10.1023/A:1024149923693)

Selman, C., and Leeuwenburgh, C. (2003) The role of Id2 and apoptosis during skeletal muscle remodeling. AJP: Regulatory, Integrative and Comparative Physiology, 284(2), R538-R539. (doi:10.​1152/​ajpregu.​00679.​2002)

Drew, B., Phaneuf, S., Dirks, A., Selman, C., Gredilla, R., Lezza, A., Barja, G., and Leeuwenburgh, C. (2003) Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart. AJP: Regulatory, Integrative and Comparative Physiology, 284(2), R474-80. (doi:10.​1152/​ajpregu.​00455.​2002)

Selman, C., Grune, T., Stolzing, A., Jakstadt, M., McLaren, J.S., and Speakman, J.R. (2002) The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, microtus agrestis. Free Radical Biology and Medicine, 33(2), pp. 259-265. (doi:10.1016/S0891-5849(02)00874-2)

Selman, C., McLaren, J.S., Collins, A.R., and Speakman, J.R. (2002) Voluntary exercise has only limited effects on activity of antioxidant enzymes and does not cause oxidative damage in a small mammal. Journal of Nutrition, 132(6 Supp), 1784S-1786S.

Speakman, J.R., Selman, C., McLaren, J.S., and Harper, E.J. (2002) Living fast, dying when? The link between aging and energetics. Journal of Nutrition, 132(6), 1583S-1597S.

Selman, C., McLaren, J.S., Collins, A.R., Duthie, G.G., and Speakman, J.R. (2002) Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel running. Archives of Biochemistry and Biophysics, 401(2), pp. 255-261. (doi:10.1016/S0003-9861(02)00050-4)

Selman, C., Korhonen, T.K., Bünger, L., Hill, W.G., and Speakman, J.R. (2001) Thermoregulatory responses of two mouse Mus musculus strains selectively bred for high and low food intake. Journal of Comparative Physiology B: Biochemical, Systemic and Environmental Physiology, 171(8), pp. 661-668.

Selman, C., Lumsden, S., Bünger, L., Hill, W.G., and Speakman, J.R. (2001) Resting metabolic rate and morphology in mice (Mus musculus) selected for high and low food intake. Journal of Experimental Biology, 204(4), pp. 777-784.

Lindsay, S., Ansell, J., Selman, C., Cox, V., Hamilton, K., and Walraven, G. (2000) Effect of pregnancy on exposure to malaria mosquitoes. Lancet, 355(9219), p. 1972. (doi:10.1016/S0140-6736(00)02334-5)

Selman, C., McLaren, J.S., Himanka, M.J., and Speakman, J.R. (2000) Effect of long-term cold exposure on antioxidant enzyme activities in a small mammal. Free Radical Biology and Medicine, 28(8), pp. 1279-1285. (doi:10.1016/S0891-5849(00)00263-X)

Redman, P., Selman, C., and Speakman, J.R. (1999) Male short-tailed field voles (Microtus agrestis) build better insulated nests than females. Journal of Comparative Physiology B: Biochemical, Systemic and Environmental Physiology, 169(8), pp. 581-587.

This list was generated on Mon Sep 26 07:16:48 2016 BST.