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Yarwood, Stephen

Department: Biochemistry and Molecular Biology

Specialist subjects:
Biochemistry Cell Biology Cellular Signalling

Biographical details:
Dr Stephen Yarwood carried out research toward a PhD in Biochemistry at the Hannah Research Institute, which was awarded at the University of Glasgow in 1998. His studies at this time were aimed at understanding the roles of cyclic AMP and the MAP kinase, ERK, in controlling preadipocyte differentiation. Following this he continued for three years as a Post Doctoral Fellow in the laboratory of Professor Miles Houslay in the Division of Biochemistry and Molecular Biology in the Institute of Biomedical and Life Sciences, University of Glasgow. During this period his research was centered on the identification of protein interaction partners for cyclic AMP-specific phosphodiesterases. After being appointed to a Lectureship in the University of Glasgow in 1999, he took Sabbatical leave, funded by a Human Frontiers Science Program Fellowship (November 1999-January 2001) at the Ontario Cancer Institute, Toronto, Canada. Here he investigated the impact of extracellular matrix on global gene expression patterns. He is currently based in the Wellcome Cell Biology Laboratory of the University of Glasgow. Since returning from Canada his research interests have been aimed at understanding the cellular and molecular basis of the cyclic AMP signaling cascade, particularly the EPAC/Rap1 signaling system. This has given rise to the first identification of a scaffold protein that enhances EPAC activity toward Rap1 (1, 2). Moreover, his laboratory carried out the first study on the mechanisms by which EPAC might suppress gene expression in cells (3). He has been awarded a number of research grants to support his work, including those from the BBSRC, European Commission, Royal Society and SHERT, and has 24 publications since 1995 to his name. 1. Borland, G., Gupta, M., Magiera, M.M., Rundell, C.J., Fuld, S., Yarwood, S.J. (2006) Mol Pharmacol. 69, 374-84. 2. Gupta, M. & Yarwood, S. J. (2005) J Biol Chem 280, 8109-16. 3. Fuld, S., Borland, G. & Yarwood, S. J. (2005) Exp Cell Res 309, 161-73.

University contact information:
phone: 0141 330 3908
email: S.Yarwood@bio.gla.ac.uk
web: http://www.gla.ac.uk:443/ibls/staff/staff.php?who=PnPeSd

Home contact information:
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