PhD Programmes and Projects
British Heart Foundation 4 Year PhD Scholarships
Deadline: 16th November 2012
Stipend: £19,919 per annum
This award, lead by Prof Rhian Touyz and co-directed by Prof Andrew Baker and Prof Godfrey Smith, covers five research themes:
- Vascular Pathophysiology and Therapy
- Heart Research
- Diabetes, Renal Endocrine and Metabolic Medicine
- Genetics, Genomics and Systems Medicine Research
- Clinical Trials and Implementation Research
Supervisors are drawn from a wide range of areas. There is an intensive first year of training in research techniques and theory plus three research placements culminating in the award of an MRes. This is followed by a 3 year PhD research project. Scholarships are available to outstanding students from broad ranging disciplines. Applications from outstanding international students are encouraged.
Please visit the website for more information or for further details contact:
Prof Godfrey Smith on 0141 330 5963 email Godfrey.Smith@glasgow.ac.uk
Prof Andrew Baker on 0141 330 1977, email Andrew.H.Baker@glasgow.ac.uk
To apply, please complete an application using the online application system
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Doctoral Training in Cell & Proteomic Technologies
Deadline: Currently closed, next cycle coming soon
This programme is supported by the EPSRC and the host universities and is run with the College of Science and Engineering. It provides students with structured training in the field of cell and proteomic technologies (MRes) as well as the opportunity to study for a PhD. The focus of the programme involves the application of new analytical technologies, developed from within the engineering and the physical sciences, in answering challenging biomedical questions.
For further information click here.
Applicants must use the online application system. On the Programme of Study section of the application, please select "research programme" and then "Biochemistry and Molecular Biology PhD" from the drop-down menu. "Jon Cooper" should be added as the prospective supervisor, and the information noted above can be copied and pasted into the research proposal section. Within the Finance section of the form, please state "EPSRC Scholarship in Cell and Proteomic Technologies".
Marie Curie Training Network - "Adenoviruses as novel clinical treatments"
Deadline: Currently closed, next cycle coming soon
Framework 7 Initial Training Network (ITN): ADVance: Adenoviruses as novel clinical treatments. This network integrates 8 leading academic centres and 4 private companies under a single umbrella to create an opportunity for scientists in adenovirus (ADV) research focusing on virus biology and technology application to vaccination and treatment of cancer and cardiovascular disease.
For further information on this award, please click on the the following link Marie Curie Training Network
This award is available at multiple institutions across Europe. To apply to study at the University of Glasgow, please complete an application using the online application system. When you reach the programme of study page, please select "Medicine and Therapeutics, PhD" from the list of available options. "Marie Curie Training Network Award" should also be entered on the page requesting information on how you plan to finance your studies.
The closing date for applications is 15th March 2012 and the application process is open from early January 2012.
Further information on the application process for postgraduate study in other institutions, will be available on the Marie Curie Training Network web page shortly.
Please contact Professor Andrew Baker if you have any enquiries relating to this award.
CRUK Studentships
PhD Studentships in the Cell Biology of Cancer
Deadline: Currently closed, next cycle coming soon
See www.beatson.gla.ac.uk/Studentships/ for more details
We aim to recruit PhD students who have or expect to obtain a very good honours degree in Life Sciences. They should also have an aptitude for experimental work and be highly committed to pursuing a career in cancer research. The Beatson has an excellent reputation and success record in training its graduate students who go on to research positions throughout the world. Students, whilst being trained at the Institute working within our research groups, matriculate with the University of Glasgow.
Our studentships, which are funded by Cancer Research UK for 4 years, usually start in October and provide students with a non-taxable stipend (for their living expenses) as well as their university matriculation fees. Studentships are open to UK, EU and non-EU graduates. Places are usually advertised in October with a deadline for applications in November and interviews in January, for a start date the following year.
We will consider applications from self-funded students at anytime but they will still be subject to our normal evaluation and interview procedures.
Doctoral Training in Biotechnology and Biological Sciences
Some of these PhDs will be supported by our new BBSRC Doctoral Training Partnership Award.
Deadline: Call opening in September
Stipend: £13,848 per annum
Details of the PhD projects available are listed here.
This programme provides students with cutting-edge research opportunities to examine fundamentally important biological processes. Projects will align with BBSRC strategic priorities, www.bbsrc.ac.uk
Students will carry out two 12-week mini-projects and generic research skills training prior to selecting their PhD. The students accepted onto this programme will be part of a cohesive and supportive cohort of students throughout their studies.
We recognise that it is important for PhD students to engage in work experience that does not directly relate to their PhD to understand the wider context of their research and to broaden their horizons. These studentships will therefore include non-academic work experience placements during their PhD.
We strongly recommend that students examine the PhD opportunities and contact potential supervisors to discuss the projects they are interested in before applying to the Programme. The final selection of projects will not be made until after the 12-week mini-projects (unless exempt) but students may indicate their PhD project of preference. If students are interested in more than one project they may indicate the order of preference.
Applicant Instructions
These are 4-year PhD studentships and students should apply online here.
The start date is October 2012 and applicants will normally be expected to reside (or have residency) within the UK or EU. The financial package will include a four year stipend, approved University fees, Research Training Support Grant and a Conference Allowance.
On the Programme of Study section of the application please select “Neuroscience and Biological Sciences PhD” from the drop down menu. On this same page please place their preferred project title(s) within the free text area and note the project supervisor(s) [see above] within the relevant section, this information is referenced here.
Doctoral Training in Medical Research
Deadline: Call opening in September
Stipend: £13,848 per annum
Details of the PhD projects available are listed here.
This MRC funded programme provides students with cutting-edge research opportunities in Medical Research. Projects will align with MRC strategic priorities, www.mrc.ac.uk
We strongly recommend that students examine the PhD opportunities and contact potential supervisors to discuss the projects before applying. If students are interested in more than one project they may indicate the order of preference.
Applicant Instructions
These are 3.5-year PhD studentships and students should apply online here.
The start date is October 2012 and applicants will normally be expected to reside (or have residency) within the UK or EU. The financial package will include a 3.5 year stipend, approved University fees, Research Training Support Grant and a Conference Allowance.
On the Programme of Study section of the application please select “Medicine and Therapeutics PhD” from the drop down menu. On this same page please place the project title(s) within the free text area and note the project supervisor(s) [see above] with the relevant section, this information is referenced here.
The PsySTAR Programme at the University of Glasgow
Psychiatry: Scottish Training in Academic Research
Deadline: Currently closed, next cycle coming soon
The PsySTAR Programme is funded by the Medical Research Foundation/Medical Research Council, to provide 4 year fellowships so a cohort of the UK's most able psychiatrists can undertake PhDs under the supervision of Scotland's most successful basic and clinical scientists. The four Scottish biomedical universities were awarded the funding to establish the cohort in open competition with the UK's other universities.
PsySTAR supervisors at the University of Glasgow
Lord Kelvin / Adam Smith Scholarships
The prestigious Lord Kelvin/Adam Smith Scholarship scheme was established in 2007 to support the development of innovative, boundary-crossing research at the University and is now in its fourth year. The scheme supports new partnerships between members of staff and will offer outstanding research students both from home and abroad the opportunity to undertake doctoral training in the context of cutting edge interdisciplinary research projects.
Each Scholarship will run for 4 years and will provide the successful students with a stipend at the Research Council recommended rates (£13,590 for 2011-12). On top of this the project will benefit from a generous contribution towards research and travel costs.
The competition for these studentships for autumn 2011 entry has now closed as of 31/03/2011. It is anticipated that there will be a similar competition for entry in autumn 2012: details will be posted when available, probably late 2011 or January 2012.
Fulbright - University of Glasgow Award
Each year, one award is offered to a US citizen to pursue a one-year Master’s degree programme (or the first year of a longer Master’s or PhD programme) in any non-clinically based subject at the University of Glasgow. The successful candidate will be selected by the Fulbright Commission and the Institute of International Education (IIE).
Award Benefits
In addition to a full tuition fee waiver from the University of Glasgow the awardee will receive £10,000, which is intended as a contribution towards general maintenance costs (accommodation, travel, subsistence, etc) while in the UK. This will be paid in instalments directly to the grantee upon arrival in the UK. Limited sickness and accident benefit coverage (typically not needed with free access to the NHS) is also provided.
All grantees in the UK attend a 3-day orientation program on arrival in September, a 5-day Fulbright Forum in January and a farewell event, the Fulbright 'End-cap'. The Commission has arranged a number of memberships for grantees during their stay and will assign a British alumna/us as a mentor.
Selection Criteria
Minimum eligibility for this award category:
- US citizen (resident anywhere but the UK)
- Rigor in scholarly enquiry and academic or professional excellence
- Strong reasons for wishing to pursue the proposed project in the UK
- Interest in the peoples and cultures of the UK
- Clear set of objectives for the Fulbright year
- Commitment to the host community through volunteer and extra-curricular activity
- Candidates need not be recent graduates, and financial need is not a factor in the selection process. The program seeks the widest possible variety of fields and career goals among applicants, including the arts and professional studies in addition to traditional academic disciplines. Preference will be given to those who do not have extensive experience in the UK.
In making these awards the Commission is looking not only for academic excellence but a focused application, a range of extracurricular and community activities, demonstrated ambassadorial skills, a desire to further the Fulbright Programme and a plan to work for the betterment of the home and host countries both during and after studies.
For further information and for application instructions, please visit the Fulbright website.
Deadline for applications for academic session 2012-13: Currently closed, next cycle coming soon
PhD on immunogenetic mechanisms driving bone disease
A PhD position is available in the European FP7 Marie Curie Initial Training Network OSTEOIMMUNE. Osteoimmunology is an emerging supra-disciplinary field of research aiming at understanding the interactions between the bone and immune systems. The consortium OSTEOIMMUNE offers structured training for early stage researchers within an established network of leading scientists and clinicians in the fields of immunology, bone biology, rheumatology, molecular biology, genetics and drug development. The research project will focus on the influence of ankylosing spondylitis-associated genes on the potential of myeloid cells to differentiate into bone eroding osteoclasts. The candidate's research activities at the Institute of Infection, Immunity & Inflammation, University of Glasgow, will be supplemented by secondments at partner institutions of the OSTEOIMMUNE network. In addition the training includes the participation in workshops and summer schools organised by the OSTEOIMMUNE network. The position will be available from October 1st, 2012.
Description
The OSTEOIMMUNE consortium consists of 11 participants from 7 European Countries (Great Britain, Sweden, The Netherlands, Germany, Switzerland, Spain and Greece). The consortium will involve 14 trainees in cutting edge research designed to decipher key molecular, cellular and clinical mechanisms in the interplay between the bone and immune systems. Bone erosion is a major pathological aspect of many inflammatory-mediated arthritides including ankylosing spondylitis. Therapeutics that target this aspect of disease are urgently required. This project will use both clinical samples and an experimental spondyloarthropathy model to answer two fundamental questions: i) Does expression of the human HLA-B27 gene alter the ability of myeloid cells to differentiate into osteoclasts? ii) Can we use immunomodulatory pathways to inhibit disease-associated osteoclastogenesis? Within this project the ESR will be trained in basic and advanced immunological techniques including multiparameter flow cytometry and flow cytometric cell sorting, ex vivo generation and evaluation of osteoclasts from human and rodent samples, animal handling and welfare, clinical evaluation of spondyloarthropathy models, and micro-CT imaging. The ESR will join the graduate programme at the College of Medical, Veterinary and Life Sciences at the University of Glasgow http://www.gla.ac.uk/colleges/mvls/graduateschool/). In addition to the individual research project each local training module also comprises network-wide training activities including inter-lab exchanges (secondments), summer schools, courses in transferable skills and conferences. The trainees will also be involved in outreach activities to the public.
Additional Requirements
You are required to satisfy the eligibility criteria for Marie Curie Early Stage Researchers: You have not yet been awarded a doctoral degree and are in the first 4 years (full-time equivalent) of your research career. This includes the period of research training, starting at the date of obtaining your degree, which would formally entitle you to embark on a doctorate either in the country in which the degree was obtained or in the country in which the initial training activities are provided, irrespective whether or not a doctorate is envisaged.
You may not have resided or carried out your main activity in the UK for more than 12 months in the 3 years immediately prior to your appointment. Short stays such as holidays are not taken into account.
Qualified applicants are those with a higher-than-average masters or equivalent degree in a relevant subject (e.g. biology, biochemistry).
A strong interest in immunology, and excellent interpersonal and communication skills are essential. Prior experience in a research laboratory will be helpful. The candidate has to demonstrate work flexibility and the ability to travel to collaborating partners. Self-motivation and curiosity are essential to be part of an international interdisciplinary team of clinicians and basic scientists. The University of Glasgow aims to increase the percentage of women at the institution; therefore, women are especially encouraged to apply.
Fluency in English is essential.
Applying
To apply to study at the University of Glasgow, please complete an application using the online application system. When you reach the programme of study page, please select "Medicine and Therapeutics, PhD" from the list of available options. On this same page please place the project title within the free text area. "Marie Curie Training Network Award" should also be entered on the page requesting information on how you plan to finance your studies.
The closing date for applications is 21st September 2012.
Further details contact Dr Carl Goodyear on 0141 330 3865, email Carl.Goodyear@glasgow.ac.uk
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Characterising cellular communication between inflammatory tissue and draining lymph node
Stipend: Standard RCUK £13,590
Deadline: 27th August 2012
The relationship and interactions between cells of the immune system in the relevant draining lymph node and associated site of inflammation are critical in initiating, maintaining and regulating immune responses. However due to technical difficulties, most studies have concentrated on either the inflammatory site or the lymph node in isolation in a static manner. We have recently established in vivo imaging approaches to overcome these problems and subsequently track or ‘fate map’ these cells and their interactions in a four dimensional, spatiotemporal manner in vivo.
In this project you will gain experience of cutting edge in vivo imaging and immunological approaches and apply these to reveal the cellular and molecular interactions and their interrelationships occurring in the immune system during inflammation.
This project is in partnership with UCB Pharma and will involve a placement in their laboratories during the term of the studentship.
Please contact Professor James Brewer (james.brewer@glasgow.ac.uk) if you have any enquiries relating to this project.
How to Apply
Apply online for a Masters by Research via the online application system:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
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Economics of Forestry- Based Health Interventions PhD Studentship
Deadline: Tuesday 21st August 2012
Stipend: £13,590 per annum, plus tuition fees
There is growing interest in whether contact with ‘green spaces’, including forests and parks, carries health benefits. Both Scottish and UK public health policy documents now explicitly recognise green spaces as ‘good for health’. The evidence for these effects stems from both experimental studies in lab and field, and from population level observational studies. Several experimental studies demonstrate direct effects of perceiving these environments on a variety of physiological and psychological measures. Several observational studies show independent associations between greener environments and better population health. However, this is an emerging field of research with much work still to do to confirm, quantify and qualify any positive impacts on health. If it is true that contact with nature brings health benefits, the cost of providing and accessing such environments, the subsequent health benefits and the relative merits of such ‘environmental health care’ need to be weighed carefully.
The Forestry Commission and other forest agencies are engaged in many programmes of woodland improvement and creation, with the explicit aim of increasing the use of woodlands and prompting health benefits. These programmes provide useful natural experiments through which health impacts of environmental interventions might be assessed. However, the specifics of how any health economic analysis might be applied to these situations are not clear. The prevailing methodology employed in health economic evaluation, is to use ‘Quality Adjusted Life Years (QALYs)’ to measure health benefits of interventions in favour of the more traditional monetary measures typically used for economic appraisal in areas such as environmental and transport economics. While the QALY framework may be appropriate for Health Related Quality of Life benefits of interventions relating to the woodland environment, the broader evaluative framework offered by cost-benefit analysis might be more appropriate for the broader wellbeing aspects of the environment.
The purpose of the PhD project will be to explore the potential use of economic appraisal techniques to value and evaluate woodland interventions. A broad perspective will be adopted to explore the potential to use and combine methods from environmental, health and transport economics.
Person specification:
Applicants should hold a first class or upper second class degree in economics and preferably have demonstrable interest in, and experience of health economics. A master's qualification in a relevant discipline would be an advantage.
Award details:
This is a 3 year full time studentship and will provide an annual stipend and fees. The award is available to UK and other EU nationals only.
Further details:
More details on the project, the supervisors and the departments involved are available from Professor Richard Mitchell (Richard.Mitchell@glasgow.ac.uk), Professor Andrew Briggs (Andrew.Briggs@glasgow.ac.uk).
How to Apply:
Apply online via the online application system:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
Input the research title and named supervisor (Prof Richard Mitchell, Prof Andrew Briggs). You should select PhD MVLS from the Programme of Study menu, and upload all supporting documents, including a CV and two reference letters.
Increasing the Capacity of Mammalian Cells to Secrete Proteins
Deadline: Friday 31st August 2012
Stipend: Please see below
Supervisor team: Professor Neil Bulleid (University of Glasgow) and Dr Katharine Cain (UCB Pharma)
Two BBSRC-funded studentships are available from September 2012 to work on a joint project between Glasgow University and UCB Pharma. The successful students will be based in Glasgow but will spend a minimum of 6 months working at UCB Pharma in Slough.
The use of antibodies as therapeutic agents is now well established providing drugs for diseases such as rheumatoid arthritis and cancer. These antibodies are relatively unstable and complex molecules to synthesise. The method of choice to produce these proteins is by expression in mammalian cells. The success of this production relies upon our continued ability to improve the ability of these cells to synthesise and secrete biologically active antibody molecules. Over the past few years, great advances have been made improving transcription and translation efficiencies allowing very high levels of gene expression, so much so that expression per se is not seen as a limiting factor in protein production. Rather the emphasis has shifted to the cell's capacity to fold and secrete the synthesised polypeptide.
Project #1 funded by a BBSRC BRIC award: This project will involve characterisation of cell lines created by UCB Pharma that show an increase in the amount of secreted antibody. The knowledge gained will allow the rational creation of next generation cell lines for enhanced recombinant protein production in mammalian cells. This studentship will also involve the dissemination of knowledge to a wide range of other industrial partners allowing exposure of the student to several potential employers. The position comes with the standard research council stipend of £13,590 per annum.
Project #2 funded by an Industrial CASE partnership award: This project aims to determine the consequence co-expression of folding factors and chaperones on the capacity of mammalian cells to synthesise and secrete a diverse range of antibody molecules. This studentship comes with £4,000 per annum supplement to the standard research council stipend of £13,590 per annum.
The students employed to these positions will obtain valuable experience of working in both an academic and industrial setting. The training provided will enable the student to obtain the skills necessary for a career in the bioprocessing sector. While the project is focused on antibody production the skills learned will be applicable to the production of any recombinant protein in mammalian cells.
The candidate must have been resident in the UK throughout the 3-year period preceding the date of application for an award, not wholly or mainly for the purposes of full time education. Applicants should have received a grade of at least 2:1 or equivalent in a degree in Biological Sciences such as Biochemistry or Molecular Biology. Applicants who do not meet this threshold but have completed other postgraduate training programmes might be considered.
Formal enquiries above the post can be made to neil.bulleid@glasgow.ac.uk.
How to Apply
Apply online via the online application system:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
Input the research title and named supervisor (Prof Neil Bulleid). You should select PhD MVLS from the Programme of Study menu, and upload all supporting documents, including a CV and two reference letters.
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PhD Studentship (BMP-7 Regulation in Osteoarthritis of the Knee)
Institute of Infection, Immunity & Inflammation
Stipend: £14,000 per annum and the award includes payment of University fees
Deadline: 31st August 2012
Applications are invited for a 3 year PhD studentship to be hosted in the University of Glasgow’s Institute of Infection, Immunity & Inflammation.
This studentship will be hosted in the laboratories of Prof Iain McInnes (Director of the Institute) and will form a joint collaboration between theInstitute ofInfection, Immunity & Inflammation and the Orthopaedic Research Unit at Glasgow Royal Infirmary.
The project will investigate mechanisms through which Bone Morphogenic Protein-7 (BMP-7) is regulated in cartilage of the knee during progression of Osteoarthritis. Informal enquiries regarding the study can be addressed to Dr Iain Anthony (iain.anthony@ggc.scot.nhs.uk).
Applicants should have, or expect to obtain, a first or upper second class honours degree in a relevant biological discipline, and have a proven ability to interpret original scientific literature. Previous laboratory experience in immunology, pathology and/or molecular biology would be an advantage.
Available from September 2012
How to apply
Interested applicants should Apply online via the online application system: http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
Please also upload a Curriculum Vitae and covering letter explaining your suitability for a PhD studentship. The contact details of two academic referees (including e-mail addresses) should also be included.
Interviews are anticipated to take place in September 2012.
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An investigation of the molecular events involved in paediatric AML/APL chemotherapeutic responses.
Deadline: 16th July 2012
Stipend: £14,000 per annum, plus tuition fees
Supervisor: Dr Karen Keeshan
Dr Karen Keeshan is inviting applications for a fully funded 3-year PhD studentship in paediatric leukemia. The project will investigate the molecular signalling mechanisms involved in the chemotherapeutic responses of childhood versus adult AML/APL.
Stipend/funding amount: This scholarship will cover UK/EU tuition fees and provide a tax-free stipend of £14k. Applicants from non-EU countries are not eligible for this scholarship.
Interested candidates should have an outstanding undergraduate record (1st or upper 2nd class degree) with a strong background in cell and molecular biology. Preference will be given to candidates with experience and training in haematopoietic cell signalling and haematopoietic malignancies and MSc/MRes in biomedical science. The studentship will commence in October 2012 (with some flexibility)
How to Apply
Apply online via the online application system:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
Input the research title and named supervisor (Dr Karen Keeshan). You should select Cancer Sciences from the Programme of Study menu, and upload all supporting documents, including a CV and two reference letters.
Enquiries are to be addressed to:
Dr Karen Keeshan karen.keeshan@glasgow.ac.uk
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A synthetic biology approach to genetic engineering of bacteria for sustainable electricity production
Deadline: tbc
Stipend: £13,590
The depletion of fossil fuel reserves, global warming, energy security and the need for clean, cheap fuels has made developing sources of renewable energy a global research priority. Microbial Fuel Cells (MFCs) have the potential to generate renewable electricity from a vast array of carbon sources. This technology lends itself to power generation in remote areas. This is particularly useful in the developing world where there is very limited infrastructure and even potentially in space.
Despite the vast potential of MFCs there are many obstacles that need to be overcome before this technology can effectively be put to use. The objective of this project is to use a synthetic biology approach to genetically engineer bacteria to form stable biofilms then efficiently generate and transfer electrons to microbial fuel cell electrodes resulting in a highly versatile, reliable and sustainable energy sources.
Synthetic biology is an exciting new discipline that aims to use novel genetic techniques to reengineer and use the components of biology ranging from whole organisms to individual proteins to perform jobs for humanity (see http://syntheticbiology.org/).
You will learn a series of cutting edge molecular biology techniques and work in a highly multidisciplinary area. There will be opportunities for travel and work in the labs of US collaborators.
You will be joining a vibrant well-funded lab led by Dr Susan Rosser. Please contact Dr Rosser (susan.rosser@glasgow.ac.uk) if you require further information.
This project is a 3 year PhD funded by the EPSRC and as such is only available to UK applicants.
How to Apply
Apply online for a Masters by Research via the online application system:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
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Using synthetic Biology for metabolic pathway engineering of fine chemicals and biofuels
Deadline: tbc
Stipend: £13,590
Synthetic biology, the design and construction of new biological parts, devices, and systems or re-design of existing natural biological systems for useful purposes, has enhanced biological research in recent years, particularly in biofuels, pharmaceuticals and environmental biotechnology (see http://syntheticbiology.org/). However, a major obstacle in synthetic biology has been the lack of efficient technologies to facilitate assembly of combinations of genetic parts into novel systems and complex functions in biological settings. We have recently developed a novel efficient recombinase based assembly technology. The aim of this PhD is to apply this technology to the construction of metabolic pathways for the production of fine chemicals and biofuels.
You will learn a series of cutting edge molecular biology techniques and work in a highly multidisciplinary area. There will be opportunities for travel and work in the labs of US collaborators.
You will be joining a vibrant well-funded lab led by Dr Susan Rosser. Please contact Dr Rosser (susan.rosser@glasgow.ac.uk) if you require further information.
This project is a 3 year PhD funded by the EPSRC and as such is only available to UK applicants.
How to Apply
Apply online for a Masters by Research via the online application system:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
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Ronald Miller Scholarship 2011-12
Deadline: 17th August 2012
Stipend: £12,500 per annum
Characterisation of superoxide dismutase1 (SOD1) in degenerative myelopathy in the dog.
This project is funded for 15 months at £12.5K per annum and the student will register for a Masters of Research (entirely research based). The project will involved a range of techniques including immunohistochemisry, cell fractionation and protein analysis, molecular cloning and protein expression.
Abstract of project
Degenerative myelopathy (DM) of dogs is strongly associated with a point mutation in the Sod1 gene encoding the enzyme superoxide dismutase 1 (SOD1). SOD1 converts superoxide anions into hydrogen peroxide and is a defense mechanism against reactive oxygen species. SOD1 mutations are strongly associated with the inherited human motor neuron disease, familial amyotrophic lateral sclerosis (fALS). There are a variety of documented SOD1 point mutations in fALS, many of which are predicted to induce a conformational change in the corresponding protein. It has been proposed that these resultant misfolded SOD1 proteins acquire a cellular toxicity involving protein aggregate formation, altered SOD1 cellular distribution, aberrant SOD1 association with mitochondria and altered SOD1 enzymatic activity. The impact of the Sod1 mutation in DM on the properties and consequent function of SOD1 protein is currently unknown. This study on SOD1 within the context of DM will address the following questions:
- Does the mutation alter the conformation and biochemical properties of SOD1 in DM?
- Does the mutation alter the cellular distribution and propensity of SOD1 to form aggregates?
- Is there a direct interaction between normal SOD1 and SOD1 expressed from the mutant gene?
The characterization of the properties of SOD1 in DM will help identify pathogenic mechanisms associated with this mutation. Furthermore, establishing a commonality between fALS and DM will be of mutual benefit to both research communities and assist with the identification of potential therapeutic targets and reliable diagnostic markers.
Background
For several years our group has been investigating the nature of the pathology of DM. DM affects older dogs and is characterised by bilateral ataxia paresis affecting the pelvic limbs and in later stages the thoracic limbs (1,2). The pathology shows pronounced axonal degeneration within regions of the spinal cord and also a reduction in neurons in the red nucleus. Furthermore, the presence of inclusion bodies within neurons at affected areas in DM are similar to the inclusion bodies that are a pathological hallmarks of fALS (3). No treatments are currently available for DM and elective euthanasia is the usual outcome within approximately 10 months of initial diagnosis.
A point mutation in the Sod1 gene 118G>A (E40K) was recently identified in the majority of a population of Welsh Corgi dogs and other breeds diagnosed with DM (4). However, the identical mutation has not been identified in fALS (http://alsod.iop.kcl.ac.uk/index.aspx). We have confirmed this mutation in DM dogs following development of a PCR based genotyping method as part of an ongoing PhD project investigating potential biomarkers of DM in CSF (School of Veterinary Medicine, University of Glasgow). While the majority of cases diagnosed on clinical criteria are homozygous for the Sod 1 mutation, a significant proportion of clinically diagnosed DM and also asymptomatic cases are heterozygous. Thus, a genetic test alone is insufficient to diagnose DM and the relationship between the genotype and pathology remains unclear.
Neurodegeneration in fALS has been proposed to be a consequence of alterations in the conformation of SOD1 (5). The pathogenic process may involve the formation of SOD1 aggregates, altered cellular distribution and/or the disruption of mitochondria through a direct association with misfolded SOD1 (6).
This project will test the hypothesis that the Sod1 mutation in DM induces a misfolded conformation that affects the solubility properties, its association with mitochondria and aggregate accumulation.
How to Apply
Apply online for a Masters by Research via the online application system:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
Input the research title, named supervisor (Dr Mark McLaughlin) and add the sponsor as the Roland Miller Scholarship. You should select Veterinary Medicine from the Programme of Study menu.
Deadline for Applications: 17th August 2012
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ParaMet PhD Projects
Deadline: 31st July 2012
The ParaMet initial training programme, a collaborative network funded by the European Commission and coordinated by the University of Glasgow, invites applications for
12 PhD Studentships
The network aims to identify key areas in the metabolism of protozoan parasites causing malaria and sleeping sickness that are exploitable for discovery of urgently needed new drugs against these diseases. This will be achieved by multidisciplinary research projects supervised by experts from academia and pharmaceutical industry.
ParaMet will train highly talented young scientists in advanced technologies such as high content RNAi screening, transcriptomics, metabolomics, mathematical modelling and drug discovery through biochemical and structural approaches. Thus the programme offers a unique opportunity to outstanding applicants to engage in the drug discovery process in an academic and industrial setting.
Please familiarise yourself with the eligibility criteria published on the ParaMet website (www.paramet.eu) before uploading your application.
Applications must be submitted online via
www.paramet.eu or directly through
https://www.paramet-application.eu
by 31st July 2012
Please click here for a list of potential research projects
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The role of microRNAs in the host-parasite relationship in the veterinary nematode Haemonchus contortus
Deadline: 17th August 2012
Stipend: £15,590 per annum
Supervisors: Dr Collette Britton and Professor Eileen Devaney
A PhD position is available with Dr Collette Britton and Professor Eileen Devaney to investigate the role of microRNAs in the host-parasite relationship in the important veterinary nematode Haemonchus contortus. The successful applicant will join a small team of researchers working on various aspects of microRNAs in parasitic nematodes. The project builds upon recent studies on the identification and characterization of microRNAs in H. contortus.
The studentship is funded by EBLEX and the University of Glasgow Industrial PhD scheme for a period of 3.5 years starting in October 2012.
Applicants should have a 1st or 2:1 degree in an appropriate subject such as immunology, molecular biology or biochemistry and a strong interest in host-parasite interactions. Applicants must be UK or EU citizens.
For further information please contact Dr Collette Britton (collette.britton@glasgow.ac.uk) or Professor Eileen Devaney (eileen.devaney@glasgow.ac.uk).
How to apply
Apply online via the online application system:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
Applications should include a full CV and the names and email contacts of two academic referees.
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An investigation of endemic and emerging tick-borne protozoa and rickettsia in Scottish livestock
3 years funding from Scottish Government to support a PhD project (Strategic Partnership on Animal Science Excellence)
Fees paid. Stipend of £14,800 in first year
Supervisors: Dr. Willie Weir, Dr. Frank Katzer, Professor Brian Shiels
Background and objectives
It has long been recognised that tick-borne pathogens represent a threat to livestock health and productivity in Scotland. While some pathogen species have been well characterised, for example Babesia divergens and Anaplasma phagocytophilum, little information is available on other species of tick-borne protozoa known to exist in the UK. This project aims to determine the distribution and prevalence of protozoan and rickettsial pathogens in an endemic area of Scotland. Research will involve sampling cattle and sheep on selected farms and applying molecular diagnostic techniques to identify infected individuals. The molecular data will then be integrated with host information collected at the time of sampling, to provide insights into disease epidemiology and examine the impact of co-infections.
The project will require a significant amount of fieldwork and the student will be expected to collect the samples themselves or under the direction of a veterinary surgeon. The laboratory-based aspect of this project will focus on the development and application of novel molecular diagnostic methods for the pathogens under study. Sample processing and data analysis will be conducted principally at the University of Glasgow Veterinary School, however there will be an opportunity for a placement at the Moredun Research Institute for any necessary parasitological work. Overall, this PhD project will provide the student with a good grounding in molecular parasitology and population-based data analysis techniques.
Eligibility
We welcome applications from veterinary graduates or individuals with a degree in a biological science and an interest in parasitology, data modeling or population studies. A high level of motivation is essential, as the successful candidate will be expected to contribute to the design of the study, co-ordinate the fieldwork and liaise with practicing veterinary surgeons and colleagues at local Veterinary Investigation Centres.
Apply online via the online application system:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
For informal enquiries, please contact Willie Weir (willie.weir@glasgow.ac.uk)
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Optimising the role of the Dental Health Support Worker in a national early years intervention (Childsmile Practice)
Deadline: Monday 23rd July 2012
Stipend: £13,590 per annum plus tuition fees (UK and EU equivalent)
Supervisors: Dr Wendy Gnich and Dr Andrea Sherriff (Community Oral Health Section, Dental School)
Summary of project
The dental health of children in Scotland is an important public health issue. Although improving, around a third of children have decayed teeth by the time they reach their first year of school, and stark socio-economic inequalities in oral health exist. In order to tackle these problems, the Scottish government has funded a national oral health improvement programme (Childsmile). Childsmile’s overarching aims are to improve the oral health of children in Scotland and reduce inequalities in dental health and in access to dental services. There is also potential for other health impacts particularly with regard to diet and obesity.
‘CS Practice’ provides a universally-accessible, child-centred NHS dental service from birth. The initiative is introduced to the family by their public health nurse who will either, refer straight to a dental practice or, for those identified as having greater needs, offer additional, tailored support via a Dental Health Support Worker (DHSW), a community health worker role developed specifically as part of Childsmile. DHSWs work with families to facilitate regular attendance at practice, and give oral health advice. As Childsmile has been rolled out across Scotland, the DHSW role has been tailored to local circumstances, resulting in variability in practice, and potentially effectiveness.
The studentship focuses on the role of the DHSW within Childsmile Practice. The ultimate aim is to make recommendations about how DHSWs can best deliver their intended role. More specifically, the objectives of this doctoral work are to gain an in-depth understanding of key stakeholders’ (including PHNs, DWSWs, Dental professionals and families) perceptions of the utility of the role and increase understanding of which variants (contextual and those associated with delivery) impact on its effectiveness.
The research has been prioritised within a national evaluation strategy for the Childsmile programme and will compliment a wider programme of mixed-method research exploring the efficacy of the DHSW role within the programme.
An appropriate research strategy will need to be developed and /or selected. A case study approach is envisaged. The design and exact methodology will be developed by the successful candidate with supervision. It is likely that the methods will be qualitative (e.g. in depth interviews, focus-groups and documentary analysis), although the study may benefit from quantitative analysis of Childsmile’s national monitoring data.
Training and opportunities
The successful applicant will join a highly experienced team comprising experts in the evaluation of complex interventions; experts in qualitative and mixed-methods research and consultants in Dental Public Health. They will have the opportunity to collaborate with regional NHS-based research teams and be supported by a strong research and administrative infrastructure with access to expert statistical advice should they chose to include quantitative methods in the case-studies. Links will be made with the Institute of Health and Well-being.
The is an excellent opportunity to gain skills in the evaluation of a complex intervention within a primary healthcare setting, with the potential to make a direct contribution to the improvement of a public health programme with international significance. While the project focuses on oral health, both, the knowledge developed as a result of the study, and the methodological expertise gained, is highly transferable to other areas.
Duration and Funding:
This a 3 year full-time studentship. The evaluation of Childsmile is funded by the Scottish Government. Tuition fees for UK and EU citizens, and a stipend of £13,590 p.a. will be awarded to the successful applicant. Additional funding will cover consumables and travel.
Anticipated Start Date: 1st October 2012
How to apply:
We welcome applications from students with an Honours or Masters degree in a relevant social science discipline (e.g. psychology or sociology), medical or allied health professions or other relevant discipline. Theoretical and practical knowledge of qualitative or mixed-methods research would be beneficial.
This studentship is open to all nationalities but the candidate has to meet general English language requirements (http://www.gla.ac.uk/postgraduate/howtoapplyforataughtdegree/englishlanguagerequirements/).
Apply online via the online application system: http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
Input the research title, named supervisors and add the sponsor as the ‘Evaluation of Childsmile’, as per the information above.
Please upload Full CV, contact details of at least 2 referees and a covering letter (clearly outlining suitability for the studentship and why you are interested in applying).
For further information or informal enquiries please contact Dr Wendy Gnich: Wendy.Gnich@glasgow.ac.uk. Please also see www.child-smile.org.co.uk
Interviews will be held mid-August 2012.
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Performance and patient experience of Coban2 compression system for lymphoedema
Deadline: Wednesday 27th June 2012
Stipend: £14,290 (first year) plus tuition fees
Supervisor:
Dr Lorna Paul (Reader in Rehabilitation), Academic - (School of Engineering).
Funding Available: Industrial Partnership Funded. Funded by 3M and the College of Medicine, Veterinary and Life Sciences, and School of Medicine, University of Glasgow.
3.5 years funding available; Stipend £14,290 (first year) plus fees paid
Summary of project:
We invite you to apply for an Industrial Partnership PhD based in Nursing & Health Care School, University of Glasgow and jointly supervised with Biomedical Engineering.
Lymphoedema is a long term condition which has significant impact on quality of life, mobility and independent living. The 3M Coban2 Compression system has recently been introduced to the market. It is reported to be effective in reducing limb volume in people with upper or lower limb lymphoedema. However little is know about how the system performs in relation to patient activity over time while limb volume is reducing and to what extent compression levels are maintained.
The aims of the PhD are
1) to examine short and long term effects of 3M Coban2 Compression system in terms of the interface pressures (i.e. the pressure between the skin and bandaging)
2) to evaluate the effect of physical activity on limb volume and interface pressures of people with lymphoedema when using the 3M Coban2 Compression system
3) to examine the effectiveness of the 3M Coban2 Compression system from the patients perspective i.e. in terms of pain, comfort, function.
The studentship will involve undertaking a systematic review or scoping study on the effectiveness of compression bandaging in the management of upper or lower limb lymphoedema, designing and implementing two studies; one investigating the effects of 3M Coban2 Compression system on interface pressures, limb volume, pain and function and designing a second investigation of the effect of physical activity on the efficacy of the 3M Coban2 Compression system.
If you would like further information please contact Lorna.Paul@glasgow.ac.uk.
How to apply:
You should have a 1st or 2.1 Honours degree in nursing or one of the allied health professions and a basic knowledge of lymphoedema and its management. Clinical experience of lymphoedema management is not essential as clinical training and advice will be provided by Margaret Sneddon, an expert in lymphoedema practice and education.
If you would like to apply, please send a CV and covering letter (clearly stating in your letter why you would like to be considered for this studentship) to Emma.Fisher@glasgow.ac.uk. Please also supply the details of two academic referees.
Closing date for applications: 27th June 2012 at 12 noon. Interviews are expected to be held on the 24th July 2012.